ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	8.88837500
2	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	5.20188926
3	piRNA metabolic process (GO:0034587)	5.04822460
4	fucose catabolic process (GO:0019317)	4.40267388
5	L-fucose metabolic process (GO:0042354)	4.40267388
6	L-fucose catabolic process (GO:0042355)	4.40267388
7	protein prenylation (GO:0018342)	4.29313928
8	prenylation (GO:0097354)	4.29313928
9	neural tube formation (GO:0001841)	4.19798583
10	peroxisome fission (GO:0016559)	4.18967433
11	platelet dense granule organization (GO:0060155)	4.17322958
12	negative regulation of telomere maintenance (GO:0032205)	4.03917383
13	protein-chromophore linkage (GO:0018298)	4.01962623
14	epithelial cilium movement (GO:0003351)	3.80682105
15	histone H2A acetylation (GO:0043968)	3.62426005
16	histone mRNA catabolic process (GO:0071044)	3.60343801
17	regulation of meiosis I (GO:0060631)	3.59827241
18	seminiferous tubule development (GO:0072520)	3.58353800
19	reciprocal meiotic recombination (GO:0007131)	3.58205568
20	reciprocal DNA recombination (GO:0035825)	3.58205568
21	cilium or flagellum-dependent cell motility (GO:0001539)	3.57825151
22	lipopolysaccharide biosynthetic process (GO:0009103)	3.55897287
23	olfactory bulb development (GO:0021772)	3.51179913
24	centriole replication (GO:0007099)	3.44466757
25	DNA double-strand break processing (GO:0000729)	3.43007150
26	cullin deneddylation (GO:0010388)	3.39129573
27	regulation of centrosome duplication (GO:0010824)	3.28540510
28	sphingosine metabolic process (GO:0006670)	3.24554815
29	regulation of male gonad development (GO:2000018)	3.24453578
30	cilium movement (GO:0003341)	3.22690703
31	telomere maintenance via telomerase (GO:0007004)	3.17178703
32	protein K11-linked deubiquitination (GO:0035871)	3.15105440
33	polyol catabolic process (GO:0046174)	3.11646133
34	regulation of telomere maintenance (GO:0032204)	3.09892815
35	RNA destabilization (GO:0050779)	3.06290738
36	cilium morphogenesis (GO:0060271)	3.02785187
37	glutathione derivative biosynthetic process (GO:1901687)	3.02035858
38	glutathione derivative metabolic process (GO:1901685)	3.02035858
39	ether lipid metabolic process (GO:0046485)	3.01263981
40	protein deneddylation (GO:0000338)	2.99953744
41	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.98065298
42	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.97282666
43	presynaptic membrane assembly (GO:0097105)	2.97022793
44	double-strand break repair via homologous recombination (GO:0000724)	2.96504518
45	reflex (GO:0060004)	2.96181911
46	transmission of nerve impulse (GO:0019226)	2.95651483
47	DNA-dependent DNA replication (GO:0006261)	2.94375122
48	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	2.91042606
49	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.89667025
50	inositol phosphate catabolic process (GO:0071545)	2.87768866
51	recombinational repair (GO:0000725)	2.86996475
52	limb bud formation (GO:0060174)	2.86525066
53	lipopolysaccharide metabolic process (GO:0008653)	2.84956100
54	gene silencing by RNA (GO:0031047)	2.81931281
55	cornea development in camera-type eye (GO:0061303)	2.80462174
56	sphingoid metabolic process (GO:0046519)	2.78810369
57	pyrimidine nucleobase catabolic process (GO:0006208)	2.76380243
58	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.74944517
59	regulation of protein glycosylation (GO:0060049)	2.71468589
60	regulation of sequestering of triglyceride (GO:0010889)	2.70437271
61	intraciliary transport (GO:0042073)	2.70207989
62	regulation of centrosome cycle (GO:0046605)	2.70032173
63	resolution of meiotic recombination intermediates (GO:0000712)	2.69708300
64	positive regulation of meiosis (GO:0045836)	2.69691567
65	glycerophospholipid catabolic process (GO:0046475)	2.69425682
66	cilium assembly (GO:0042384)	2.69384432
67	embryonic epithelial tube formation (GO:0001838)	2.68993008
68	proteasome assembly (GO:0043248)	2.68721432
69	cilium organization (GO:0044782)	2.68604636
70	regulation of timing of cell differentiation (GO:0048505)	2.67744780
71	diol metabolic process (GO:0034311)	2.67538750
72	sympathetic nervous system development (GO:0048485)	2.67179772
73	inner ear receptor cell differentiation (GO:0060113)	2.66747573
74	axoneme assembly (GO:0035082)	2.66300381
75	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.65228454
76	protein polyglutamylation (GO:0018095)	2.65216427
77	gamma-aminobutyric acid transport (GO:0015812)	2.65107839
78	nonmotile primary cilium assembly (GO:0035058)	2.64646675
79	DNA integration (GO:0015074)	2.63415495
80	forebrain morphogenesis (GO:0048853)	2.62358242
81	inositol phosphate dephosphorylation (GO:0046855)	2.62007877
82	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.62007877
83	brain morphogenesis (GO:0048854)	2.60871171
84	preassembly of GPI anchor in ER membrane (GO:0016254)	2.60577758
85	spermatid development (GO:0007286)	2.59866880
86	male meiosis I (GO:0007141)	2.58554164
87	kinetochore organization (GO:0051383)	2.56811115
88	indolalkylamine metabolic process (GO:0006586)	2.53751359
89	kinetochore assembly (GO:0051382)	2.53057469
90	arginine catabolic process (GO:0006527)	2.52527503
91	peptidyl-histidine modification (GO:0018202)	2.52077150
92	appendage development (GO:0048736)	2.49297951
93	limb development (GO:0060173)	2.49297951
94	epithelial tube formation (GO:0072175)	2.47809370
95	replication fork processing (GO:0031297)	2.47401474
96	positive regulation of meiotic cell cycle (GO:0051446)	2.46992790
97	female gonad development (GO:0008585)	2.46617228
98	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	2.46192929
99	DNA catabolic process, exonucleolytic (GO:0000738)	2.46130645
100	DNA demethylation (GO:0080111)	2.45814111

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.81205877
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.48534566
3	VDR_22108803_ChIP-Seq_LS180_Human	3.35877867
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.04510837
5	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.77741795
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.77477947
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.68533003
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.65418957
9	FUS_26573619_Chip-Seq_HEK293_Human	2.57363062
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.49568286
11	P300_19829295_ChIP-Seq_ESCs_Human	2.46774360
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.17812849
13	EWS_26573619_Chip-Seq_HEK293_Human	2.12947453
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.12247707
15	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.07735508
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.06691460
17	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.05903224
18	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.03328280
19	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.03235993
20	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.00315232
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.91848677
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.90305468
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.89278909
24	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.87151388
25	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.73854486
26	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.73564039
27	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.73117247
28	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.66830853
29	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.61573299
30	BCAT_22108803_ChIP-Seq_LS180_Human	1.58860995
31	MYC_18940864_ChIP-ChIP_HL60_Human	1.58640661
32	AR_25329375_ChIP-Seq_VCAP_Human	1.54710811
33	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.53720941
34	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.51522869
35	ELK1_19687146_ChIP-ChIP_HELA_Human	1.51090726
36	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.50999810
37	CBP_20019798_ChIP-Seq_JUKART_Human	1.50251802
38	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.50251802
39	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.49107377
40	TCF4_22108803_ChIP-Seq_LS180_Human	1.47633540
41	SMAD4_21799915_ChIP-Seq_A2780_Human	1.45963939
42	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.45762349
43	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.45074003
44	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.44919988
45	STAT3_23295773_ChIP-Seq_U87_Human	1.43177860
46	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.42481988
47	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.42300265
48	NANOG_19829295_ChIP-Seq_ESCs_Human	1.41771677
49	SOX2_19829295_ChIP-Seq_ESCs_Human	1.41771677
50	TCF4_23295773_ChIP-Seq_U87_Human	1.39849628
51	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.36332170
52	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.33660840
53	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.32246629
54	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.32168599
55	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.30157326
56	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.29811377
57	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.28219687
58	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.27989243
59	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.27140268
60	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.25536251
61	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.25074321
62	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.24890689
63	NCOR_22424771_ChIP-Seq_293T_Human	1.23976433
64	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.23343244
65	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.22055261
66	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.21861543
67	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18699339
68	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.18699339
69	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.18581024
70	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.16412535
71	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.14969242
72	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.12663889
73	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.12198418
74	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.11709768
75	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.11502220
76	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.11214055
77	VDR_23849224_ChIP-Seq_CD4+_Human	1.11075245
78	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.09573231
79	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.08271830
80	P53_22387025_ChIP-Seq_ESCs_Mouse	1.08204924
81	AR_21572438_ChIP-Seq_LNCaP_Human	1.07782754
82	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.07109110
83	TP53_22573176_ChIP-Seq_HFKS_Human	1.06716866
84	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.05822859
85	RNF2_27304074_Chip-Seq_NSC_Mouse	1.04194306
86	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.03961569
87	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.03582056
88	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.02502047
89	IRF1_19129219_ChIP-ChIP_H3396_Human	1.00190125
90	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.00013309
91	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.98611185
92	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.98192451
93	KDM2B_26808549_Chip-Seq_REH_Human	0.98016720
94	HOXB7_26014856_ChIP-Seq_BT474_Human	0.97556684
95	CDX2_22108803_ChIP-Seq_LS180_Human	0.96454965
96	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.95118894
97	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.94958704
98	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.94809236
99	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.94478963
100	RUNX2_22187159_ChIP-Seq_PCA_Human	0.94387343

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000372_irregular_coat_pigmentation	4.51794806
2	MP0005171_absent_coat_pigmentation	4.25799324
3	MP0002938_white_spotting	4.11003888
4	MP0003136_yellow_coat_color	3.23268295
5	MP0002837_dystrophic_cardiac_calcinosis	3.15380404
6	MP0002102_abnormal_ear_morphology	3.08711054
7	MP0005174_abnormal_tail_pigmentation	2.85231339
8	MP0006292_abnormal_olfactory_placode	2.78654350
9	MP0001986_abnormal_taste_sensitivity	2.60342046
10	MP0008058_abnormal_DNA_repair	2.50704297
11	MP0005646_abnormal_pituitary_gland	2.36797120
12	MP0004147_increased_porphyrin_level	2.25909373
13	MP0008789_abnormal_olfactory_epithelium	2.15488419
14	MP0003646_muscle_fatigue	2.11575686
15	MP0001764_abnormal_homeostasis	2.10582731
16	MP0002638_abnormal_pupillary_reflex	1.96789274
17	MP0000569_abnormal_digit_pigmentation	1.88512974
18	MP0004133_heterotaxia	1.87209878
19	MP0005253_abnormal_eye_physiology	1.83201358
20	MP0002095_abnormal_skin_pigmentation	1.76587426
21	MP0005367_renal/urinary_system_phenotyp	1.71668621
22	MP0000516_abnormal_urinary_system	1.71668621
23	MP0000383_abnormal_hair_follicle	1.69639170
24	MP0000749_muscle_degeneration	1.69330303
25	MP0001984_abnormal_olfaction	1.66643604
26	MP0002234_abnormal_pharynx_morphology	1.64074485
27	MP0001529_abnormal_vocalization	1.63984006
28	MP0003283_abnormal_digestive_organ	1.61868835
29	MP0008877_abnormal_DNA_methylation	1.57694103
30	MP0005075_abnormal_melanosome_morpholog	1.47766166
31	MP0006072_abnormal_retinal_apoptosis	1.47316180
32	MP0005551_abnormal_eye_electrophysiolog	1.43654959
33	MP0001188_hyperpigmentation	1.42654292
34	MP0005394_taste/olfaction_phenotype	1.42477972
35	MP0005499_abnormal_olfactory_system	1.42477972
36	MP0002653_abnormal_ependyma_morphology	1.41839152
37	MP0003890_abnormal_embryonic-extraembry	1.41640808
38	MP0008775_abnormal_heart_ventricle	1.39724933
39	MP0002138_abnormal_hepatobiliary_system	1.36067201
40	MP0001501_abnormal_sleep_pattern	1.33877066
41	MP0000015_abnormal_ear_pigmentation	1.32200443
42	MP0002751_abnormal_autonomic_nervous	1.29026707
43	MP0001486_abnormal_startle_reflex	1.22960082
44	MP0005084_abnormal_gallbladder_morpholo	1.22837390
45	MP0005647_abnormal_sex_gland	1.21979831
46	MP0009697_abnormal_copulation	1.20567781
47	MP0003880_abnormal_central_pattern	1.17015789
48	MP0000631_abnormal_neuroendocrine_gland	1.15621161
49	MP0001324_abnormal_eye_pigmentation	1.15067041
50	MP0002254_reproductive_system_inflammat	1.13882475
51	MP0009046_muscle_twitch	1.13380418
52	MP0002160_abnormal_reproductive_system	1.12157281
53	MP0010678_abnormal_skin_adnexa	1.11673673
54	MP0003011_delayed_dark_adaptation	1.08879815
55	MP0003195_calcinosis	1.06193883
56	MP0003252_abnormal_bile_duct	1.04976125
57	MP0008872_abnormal_physiological_respon	1.04229300
58	MP0000427_abnormal_hair_cycle	1.02657471
59	MP0003937_abnormal_limbs/digits/tail_de	0.96015279
60	MP0001293_anophthalmia	0.95039022
61	MP0003718_maternal_effect	0.93256235
62	MP0003045_fibrosis	0.92991585
63	MP0002928_abnormal_bile_duct	0.92897238
64	MP0000778_abnormal_nervous_system	0.92527528
65	MP0005257_abnormal_intraocular_pressure	0.91198008
66	MP0010386_abnormal_urinary_bladder	0.90357403
67	MP0001485_abnormal_pinna_reflex	0.90323282
68	MP0002168_other_aberrant_phenotype	0.88861038
69	MP0000358_abnormal_cell_content/	0.88801002
70	MP0003950_abnormal_plasma_membrane	0.88397259
71	MP0002876_abnormal_thyroid_physiology	0.88270083
72	MP0002282_abnormal_trachea_morphology	0.87733584
73	MP0008875_abnormal_xenobiotic_pharmacok	0.87277280
74	MP0005410_abnormal_fertilization	0.86903743
75	MP0003137_abnormal_impulse_conducting	0.86820091
76	MP0005248_abnormal_Harderian_gland	0.85210174
77	MP0005395_other_phenotype	0.83589982
78	MP0003943_abnormal_hepatobiliary_system	0.83351782
79	MP0002184_abnormal_innervation	0.79726294
80	MP0003786_premature_aging	0.79626914
81	MP0001968_abnormal_touch/_nociception	0.78654537
82	MP0004215_abnormal_myocardial_fiber	0.78287446
83	MP0004270_analgesia	0.76895530
84	MP0004142_abnormal_muscle_tone	0.75333762
85	MP0000538_abnormal_urinary_bladder	0.75088687
86	MP0005310_abnormal_salivary_gland	0.74055694
87	MP0009780_abnormal_chondrocyte_physiolo	0.73841018
88	MP0005195_abnormal_posterior_eye	0.73428490
89	MP0002752_abnormal_somatic_nervous	0.73282914
90	MP0002075_abnormal_coat/hair_pigmentati	0.71383298
91	MP0005408_hypopigmentation	0.70989204
92	MP0003121_genomic_imprinting	0.69721591
93	MP0002210_abnormal_sex_determination	0.69711051
94	MP0002272_abnormal_nervous_system	0.69174448
95	MP0003698_abnormal_male_reproductive	0.68905964
96	MP0002233_abnormal_nose_morphology	0.68348601
97	MP0005391_vision/eye_phenotype	0.68144685
98	MP0004084_abnormal_cardiac_muscle	0.68083962
99	MP0003755_abnormal_palate_morphology	0.67410877
100	MP0008932_abnormal_embryonic_tissue	0.66513415

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chromsome breakage (HP:0040012)	3.80393969
2	Pancreatic cysts (HP:0001737)	3.72002187
3	Abnormality of midbrain morphology (HP:0002418)	3.68550036
4	Molar tooth sign on MRI (HP:0002419)	3.68550036
5	Methylmalonic acidemia (HP:0002912)	3.64940597
6	Chronic hepatic failure (HP:0100626)	3.51894455
7	True hermaphroditism (HP:0010459)	3.44238724
8	Pancreatic fibrosis (HP:0100732)	3.21821157
9	Volvulus (HP:0002580)	2.98018741
10	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.90299614
11	Medial flaring of the eyebrow (HP:0010747)	2.85925213
12	Neonatal respiratory distress (HP:0002643)	2.76223034
13	Bile duct proliferation (HP:0001408)	2.72230609
14	Abnormal biliary tract physiology (HP:0012439)	2.72230609
15	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.71211305
16	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.69213535
17	Hypoplasia of the fovea (HP:0007750)	2.69213535
18	Popliteal pterygium (HP:0009756)	2.66420496
19	Abnormality of the fovea (HP:0000493)	2.65891303
20	Long clavicles (HP:0000890)	2.60507704
21	Colon cancer (HP:0003003)	2.54950404
22	Nephronophthisis (HP:0000090)	2.48389078
23	Hypoplastic pelvis (HP:0008839)	2.48309074
24	Facial shape deformation (HP:0011334)	2.44270832
25	Potter facies (HP:0002009)	2.44270832
26	Hyperventilation (HP:0002883)	2.43606091
27	Retinal dysplasia (HP:0007973)	2.41261033
28	Amelogenesis imperfecta (HP:0000705)	2.37102843
29	Abnormality of the renal cortex (HP:0011035)	2.35769455
30	Cystic liver disease (HP:0006706)	2.33302167
31	Methylmalonic aciduria (HP:0012120)	2.32465464
32	Renal cortical cysts (HP:0000803)	2.30778888
33	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.22915044
34	Severe visual impairment (HP:0001141)	2.22568721
35	Amniotic constriction ring (HP:0009775)	2.21804565
36	Abnormality of placental membranes (HP:0011409)	2.21804565
37	Sclerocornea (HP:0000647)	2.19564464
38	Chorioretinal coloboma (HP:0000567)	2.18506357
39	Oculomotor apraxia (HP:0000657)	2.18232956
40	Abnormal ciliary motility (HP:0012262)	2.16294738
41	Preaxial hand polydactyly (HP:0001177)	2.14801050
42	Exotropia (HP:0000577)	2.14101987
43	Choroideremia (HP:0001139)	2.13201654
44	Abnormal pupillary function (HP:0007686)	2.11977321
45	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.10748303
46	Pendular nystagmus (HP:0012043)	2.09828144
47	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.09494191
48	Congenital primary aphakia (HP:0007707)	2.09013685
49	Abnormality of vitamin B metabolism (HP:0004340)	2.08109601
50	Type 2 muscle fiber atrophy (HP:0003554)	2.07734979
51	Congenital hepatic fibrosis (HP:0002612)	2.07702552
52	Parakeratosis (HP:0001036)	2.07509689
53	Abnormality of chromosome stability (HP:0003220)	2.07403500
54	Intestinal atresia (HP:0011100)	2.06815588
55	Brushfield spots (HP:0001088)	2.05902756
56	Stomatitis (HP:0010280)	2.03955382
57	Optic nerve coloboma (HP:0000588)	1.99612493
58	Gait imbalance (HP:0002141)	1.98874844
59	Nephrogenic diabetes insipidus (HP:0009806)	1.97784660
60	Intellectual disability, moderate (HP:0002342)	1.96344753
61	Abnormality of the labia minora (HP:0012880)	1.95611685
62	Abnormality of the renal medulla (HP:0100957)	1.94855387
63	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.94277244
64	Absent/shortened dynein arms (HP:0200106)	1.94277244
65	Small hand (HP:0200055)	1.92622435
66	Dyschromatopsia (HP:0007641)	1.92612445
67	Birth length less than 3rd percentile (HP:0003561)	1.92548570
68	Abnormal rod and cone electroretinograms (HP:0008323)	1.92294657
69	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.91767955
70	Microtia (HP:0008551)	1.90024128
71	Cerebellar dysplasia (HP:0007033)	1.89211029
72	Absent speech (HP:0001344)	1.88692173
73	Abnormal hemoglobin (HP:0011902)	1.88355937
74	Attenuation of retinal blood vessels (HP:0007843)	1.88296614
75	Abnormality of methionine metabolism (HP:0010901)	1.88116254
76	Aplastic anemia (HP:0001915)	1.88030900
77	Postaxial foot polydactyly (HP:0001830)	1.84448984
78	Abnormal respiratory epithelium morphology (HP:0012253)	1.83963409
79	Abnormal respiratory motile cilium morphology (HP:0005938)	1.83963409
80	Genital tract atresia (HP:0001827)	1.83879260
81	Postaxial hand polydactyly (HP:0001162)	1.83559227
82	Triphalangeal thumb (HP:0001199)	1.82183787
83	Thyroid-stimulating hormone excess (HP:0002925)	1.81393724
84	Decreased central vision (HP:0007663)	1.80568651
85	Congenital ichthyosiform erythroderma (HP:0007431)	1.80088294
86	Hypoplastic iliac wings (HP:0002866)	1.79534737
87	Tachypnea (HP:0002789)	1.79384178
88	Hypomagnesemia (HP:0002917)	1.76594040
89	Abnormality of the ileum (HP:0001549)	1.75309396
90	Abnormality of serine family amino acid metabolism (HP:0010894)	1.74793490
91	Abnormality of glycine metabolism (HP:0010895)	1.74793490
92	Tubular atrophy (HP:0000092)	1.74730975
93	Redundant skin (HP:0001582)	1.74392389
94	Oligohydramnios (HP:0001562)	1.74008427
95	Aganglionic megacolon (HP:0002251)	1.73874060
96	Vaginal atresia (HP:0000148)	1.72710358
97	Furrowed tongue (HP:0000221)	1.71811394
98	Anencephaly (HP:0002323)	1.71106703
99	Occipital encephalocele (HP:0002085)	1.70825805
100	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.70075370

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.09748716
2	LATS1	4.05817605
3	MAP4K2	3.56947896
4	NUAK1	3.40922769
5	IRAK2	2.98114263
6	ACVR1B	2.81700100
7	TRIM28	2.56783598
8	PLK4	2.53329175
9	BMPR1B	2.48774846
10	PRKD3	2.34994943
11	MUSK	2.30721654
12	DAPK2	2.03817147
13	BUB1	1.96180851
14	WNK3	1.95835055
15	MELK	1.88510911
16	MAPK13	1.85487646
17	ERBB3	1.85468787
18	STK38L	1.80640872
19	FGFR2	1.77457185
20	CASK	1.70927808
21	IRAK1	1.52175876
22	STK39	1.43211430
23	PINK1	1.31060532
24	PAK3	1.29513113
25	PLK3	1.27478962
26	VRK1	1.27353759
27	TNK2	1.25669114
28	TGFBR2	1.22925756
29	CAMKK2	1.19271437
30	PLK2	1.19222249
31	CDC7	1.17351751
32	TGFBR1	1.16013775
33	MKNK1	1.13479605
34	BRSK2	1.11431922
35	EPHA4	1.06531803
36	VRK2	1.06419516
37	PRKCE	1.01081988
38	MAP3K4	0.98731456
39	DYRK2	0.98698064
40	PRKD2	0.97279271
41	STK3	0.90633893
42	ZAK	0.88423303
43	EIF2AK3	0.87369499
44	ADRBK2	0.86921831
45	OXSR1	0.85584435
46	INSRR	0.83936691
47	DAPK1	0.80440221
48	MKNK2	0.79856093
49	RAF1	0.77796738
50	EIF2AK1	0.71796720
51	FER	0.71432997
52	MST4	0.70506514
53	PTK2B	0.69007828
54	PIK3CG	0.68591442
55	MINK1	0.66535632
56	MAP3K5	0.66230846
57	GRK1	0.64652614
58	LIMK1	0.62645493
59	ROCK1	0.62078972
60	PRKCH	0.61366630
61	CSNK1G2	0.61298259
62	PDK2	0.58290269
63	PLK1	0.57127034
64	ADRBK1	0.51529936
65	TNIK	0.51416094
66	CCNB1	0.50819609
67	MAP2K7	0.50663393
68	CDK8	0.48047091
69	MAPKAPK5	0.46313050
70	ATR	0.45838981
71	RPS6KB1	0.45753674
72	CAMK2A	0.44906863
73	ATM	0.44072197
74	MAP2K1	0.42656155
75	BRSK1	0.42385603
76	PBK	0.40884925
77	WEE1	0.40451827
78	CSNK1A1L	0.39414003
79	RPS6KB2	0.39218869
80	PRKCQ	0.36877351
81	NEK1	0.35964799
82	PRKG1	0.35605902
83	TAF1	0.34641779
84	BCR	0.33842292
85	PKN1	0.33679034
86	TAOK3	0.33400663
87	PRKACB	0.33083516
88	ROCK2	0.32684898
89	PRKCG	0.31236192
90	PRKD1	0.30801874
91	CSNK1G3	0.29949875
92	PNCK	0.28555625
93	CAMK1G	0.28422636
94	STK38	0.27841825
95	DAPK3	0.27781244
96	ABL1	0.26513465
97	PRKAA2	0.26398099
98	CSNK1G1	0.26362843
99	STK16	0.25769276
100	CDK9	0.24508827

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.00970374
2	Homologous recombination_Homo sapiens_hsa03440	2.76136853
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.75890915
4	Fanconi anemia pathway_Homo sapiens_hsa03460	2.42639593
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.39482117
6	Butanoate metabolism_Homo sapiens_hsa00650	2.38813737
7	Non-homologous end-joining_Homo sapiens_hsa03450	2.34152304
8	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.28076139
9	Basal transcription factors_Homo sapiens_hsa03022	2.25948582
10	Phototransduction_Homo sapiens_hsa04744	2.16707377
11	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.08563799
12	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.01600018
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.87098911
14	Propanoate metabolism_Homo sapiens_hsa00640	1.85815137
15	Glutathione metabolism_Homo sapiens_hsa00480	1.78380901
16	Protein export_Homo sapiens_hsa03060	1.75642279
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.72459896
18	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.71126788
19	Proteasome_Homo sapiens_hsa03050	1.69734796
20	Peroxisome_Homo sapiens_hsa04146	1.68872730
21	Fatty acid metabolism_Homo sapiens_hsa01212	1.66932980
22	Steroid biosynthesis_Homo sapiens_hsa00100	1.58169928
23	Caffeine metabolism_Homo sapiens_hsa00232	1.57153765
24	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.55487450
25	RNA degradation_Homo sapiens_hsa03018	1.55458077
26	Nitrogen metabolism_Homo sapiens_hsa00910	1.54223574
27	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.51866275
28	Fatty acid elongation_Homo sapiens_hsa00062	1.51260828
29	Regulation of autophagy_Homo sapiens_hsa04140	1.50025088
30	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.48524230
31	Linoleic acid metabolism_Homo sapiens_hsa00591	1.47918382
32	RNA polymerase_Homo sapiens_hsa03020	1.47582852
33	Base excision repair_Homo sapiens_hsa03410	1.42767694
34	Ether lipid metabolism_Homo sapiens_hsa00565	1.38744530
35	Chemical carcinogenesis_Homo sapiens_hsa05204	1.31198357
36	Fatty acid degradation_Homo sapiens_hsa00071	1.31095417
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.28021810
38	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.26423248
39	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.25893718
40	Sphingolipid metabolism_Homo sapiens_hsa00600	1.23990334
41	Nucleotide excision repair_Homo sapiens_hsa03420	1.14957193
42	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.13968042
43	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.10207000
44	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.09242626
45	Oxidative phosphorylation_Homo sapiens_hsa00190	1.05407029
46	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.01233142
47	beta-Alanine metabolism_Homo sapiens_hsa00410	1.00618276
48	Pyruvate metabolism_Homo sapiens_hsa00620	0.99713177
49	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.96211618
50	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.95724001
51	Mismatch repair_Homo sapiens_hsa03430	0.93792034
52	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.93585298
53	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.92428406
54	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.91615394
55	Purine metabolism_Homo sapiens_hsa00230	0.90547508
56	Taste transduction_Homo sapiens_hsa04742	0.88377093
57	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.87755596
58	Olfactory transduction_Homo sapiens_hsa04740	0.86677459
59	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.86503245
60	Nicotine addiction_Homo sapiens_hsa05033	0.80643456
61	Parkinsons disease_Homo sapiens_hsa05012	0.80274643
62	Circadian rhythm_Homo sapiens_hsa04710	0.80180740
63	Serotonergic synapse_Homo sapiens_hsa04726	0.80145036
64	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.79020753
65	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.78546218
66	ABC transporters_Homo sapiens_hsa02010	0.72818232
67	Pyrimidine metabolism_Homo sapiens_hsa00240	0.70498988
68	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.66705149
69	GABAergic synapse_Homo sapiens_hsa04727	0.65714081
70	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.65514428
71	Huntingtons disease_Homo sapiens_hsa05016	0.64916315
72	Metabolic pathways_Homo sapiens_hsa01100	0.62877987
73	Melanoma_Homo sapiens_hsa05218	0.62575342
74	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.62361877
75	RNA transport_Homo sapiens_hsa03013	0.62281792
76	Salivary secretion_Homo sapiens_hsa04970	0.61041440
77	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.58342438
78	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.56761075
79	Morphine addiction_Homo sapiens_hsa05032	0.56230627
80	Cardiac muscle contraction_Homo sapiens_hsa04260	0.54845346
81	Fat digestion and absorption_Homo sapiens_hsa04975	0.53318600
82	Lysine degradation_Homo sapiens_hsa00310	0.52625577
83	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.51964112
84	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.51112979
85	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.49266826
86	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.47479571
87	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.47376129
88	Circadian entrainment_Homo sapiens_hsa04713	0.42383388
89	Collecting duct acid secretion_Homo sapiens_hsa04966	0.42363368
90	Oocyte meiosis_Homo sapiens_hsa04114	0.38645347
91	Glycerolipid metabolism_Homo sapiens_hsa00561	0.35678381
92	Folate biosynthesis_Homo sapiens_hsa00790	0.35449003
93	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.34532135
94	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.32168742
95	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.32028641
96	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.29802484
97	p53 signaling pathway_Homo sapiens_hsa04115	0.28535782
98	Insulin secretion_Homo sapiens_hsa04911	0.28515012
99	Retinol metabolism_Homo sapiens_hsa00830	0.25706300
100	Hippo signaling pathway_Homo sapiens_hsa04390	0.24684080

CCDC58P5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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