CCDC6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.92356218
2desmosome organization (GO:0002934)5.61379249
3meiotic chromosome segregation (GO:0045132)5.39050130
4piRNA metabolic process (GO:0034587)5.17727148
5metaphase plate congression (GO:0051310)5.15390330
6monoubiquitinated protein deubiquitination (GO:0035520)5.05648495
7nuclear pore complex assembly (GO:0051292)4.73447287
8establishment of chromosome localization (GO:0051303)4.69764292
9mitotic chromosome condensation (GO:0007076)4.61270537
10bundle of His cell to Purkinje myocyte communication (GO:0086069)4.54981965
11attachment of spindle microtubules to kinetochore (GO:0008608)4.44848735
12kinetochore assembly (GO:0051382)4.40203562
13regulation of acrosome reaction (GO:0060046)4.34110168
14nuclear pore organization (GO:0006999)4.25002658
15myoblast migration (GO:0051451)4.24784537
16maturation of 5.8S rRNA (GO:0000460)4.21526061
17kinetochore organization (GO:0051383)4.18372140
18regulation of double-strand break repair via homologous recombination (GO:0010569)4.11162602
19regulation of water loss via skin (GO:0033561)4.11050735
20regulation of mitotic spindle checkpoint (GO:1903504)4.07394386
21regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.07394386
22regulation of DNA methylation (GO:0044030)4.00294598
23oocyte maturation (GO:0001556)3.99835997
24regulation of spindle organization (GO:0090224)3.99702391
25sister chromatid cohesion (GO:0007062)3.98316103
26regulation of RNA export from nucleus (GO:0046831)3.97537464
27regulation of transforming growth factor beta2 production (GO:0032909)3.97503106
28oocyte development (GO:0048599)3.97187781
29negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.93682234
30DNA methylation involved in gamete generation (GO:0043046)3.86966810
31DNA replication checkpoint (GO:0000076)3.82981022
32regulation of meiosis I (GO:0060631)3.81767100
33establishment of skin barrier (GO:0061436)3.79933605
34protein K6-linked ubiquitination (GO:0085020)3.78825854
35microtubule depolymerization (GO:0007019)3.78033021
36paraxial mesoderm development (GO:0048339)3.76527720
37pore complex assembly (GO:0046931)3.73626657
38protein localization to kinetochore (GO:0034501)3.71374920
39mitotic sister chromatid segregation (GO:0000070)3.71277942
40regulation of transcription from RNA polymerase I promoter (GO:0006356)3.70645530
41cellular response to gamma radiation (GO:0071480)3.67573683
42chromosome segregation (GO:0007059)3.65995673
43regulation of female gonad development (GO:2000194)3.64889509
44male meiosis (GO:0007140)3.63220191
45female gamete generation (GO:0007292)3.60664551
46snRNA transcription (GO:0009301)3.59206665
47inner cell mass cell proliferation (GO:0001833)3.58694905
48regulation of histone H3-K9 methylation (GO:0051570)3.54327459
49positive regulation of mitotic sister chromatid separation (GO:1901970)3.54277491
50positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.54277491
51positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.54277491
52CENP-A containing nucleosome assembly (GO:0034080)3.51593506
53negative regulation of keratinocyte proliferation (GO:0010839)3.51510670
54protein localization to chromosome, centromeric region (GO:0071459)3.51111442
55negative regulation of meiosis (GO:0045835)3.48782964
56regulation of hippo signaling (GO:0035330)3.47437559
57Golgi transport vesicle coating (GO:0048200)3.45131812
58COPI coating of Golgi vesicle (GO:0048205)3.45131812
59notochord development (GO:0030903)3.45119743
60regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.44291776
61regulation of nucleobase-containing compound transport (GO:0032239)3.43976001
62DNA damage response, signal transduction resulting in transcription (GO:0042772)3.43592661
63DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.42516566
64chromatin remodeling at centromere (GO:0031055)3.42498038
65mitotic nuclear envelope disassembly (GO:0007077)3.42468823
66intestinal epithelial cell development (GO:0060576)3.39564775
67regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.38195215
68poly(A)+ mRNA export from nucleus (GO:0016973)3.37996248
69hippo signaling (GO:0035329)3.35858804
70meiotic cell cycle (GO:0051321)3.34769999
71DNA replication-independent nucleosome organization (GO:0034724)3.33368163
72DNA replication-independent nucleosome assembly (GO:0006336)3.33368163
73regulation of establishment of cell polarity (GO:2000114)3.33362227
74maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.32461058
75DNA damage induced protein phosphorylation (GO:0006975)3.30124892
76spindle checkpoint (GO:0031577)3.29520120
77mitotic sister chromatid cohesion (GO:0007064)3.26953486
78histone demethylation (GO:0016577)3.26751567
79regulation of mitotic spindle organization (GO:0060236)3.26092381
80COPII vesicle coating (GO:0048208)3.25789799
81histone lysine demethylation (GO:0070076)3.22568781
82histone exchange (GO:0043486)3.22515609
83regulation of retinoic acid receptor signaling pathway (GO:0048385)3.20438333
84nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.18800715
85regulation of double-strand break repair (GO:2000779)3.17839176
86membrane disassembly (GO:0030397)3.17164241
87nuclear envelope disassembly (GO:0051081)3.17164241
88regulation of spindle checkpoint (GO:0090231)3.15807023
89protein localization to chromosome (GO:0034502)3.14595738
90negative regulation of histone methylation (GO:0031061)3.13889524
91cellular protein complex localization (GO:0034629)3.12157489
92epithelial cell-cell adhesion (GO:0090136)3.11083622
93protein localization to microtubule (GO:0035372)3.10894975
94regulation of meiosis (GO:0040020)3.10181977
95histone H2A monoubiquitination (GO:0035518)3.09200957
96skin morphogenesis (GO:0043589)3.07191095
97sister chromatid segregation (GO:0000819)3.06519382
98synaptonemal complex assembly (GO:0007130)3.06162448
99negative regulation of DNA repair (GO:0045738)3.05918199
100female gonad development (GO:0008585)3.04930677
101regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.04790086
102protein dealkylation (GO:0008214)3.02137156
103protein demethylation (GO:0006482)3.02137156
104reciprocal DNA recombination (GO:0035825)3.01167404
105reciprocal meiotic recombination (GO:0007131)3.01167404
106microtubule nucleation (GO:0007020)2.99614661
107positive regulation of chromosome segregation (GO:0051984)2.98905443
108DNA alkylation (GO:0006305)2.97726891
109DNA methylation (GO:0006306)2.97726891
110replication fork processing (GO:0031297)2.97715203
111meiotic nuclear division (GO:0007126)2.97506969
112regulation of cardioblast differentiation (GO:0051890)2.93934619
113regulation of keratinocyte proliferation (GO:0010837)2.92253966
114regulation of sister chromatid cohesion (GO:0007063)2.91582987
115gap junction assembly (GO:0016264)2.89929443
116male meiosis I (GO:0007141)2.88877246
117corticosteroid receptor signaling pathway (GO:0031958)2.88710227
118meiotic cell cycle process (GO:1903046)2.86203460
119regulation of chromosome segregation (GO:0051983)2.85076186
120resolution of meiotic recombination intermediates (GO:0000712)2.84690293
121regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.82763660
122ribosome assembly (GO:0042255)2.82697211
123regulation of mitotic metaphase/anaphase transition (GO:0030071)2.82291151
124protein complex localization (GO:0031503)2.80977213
125microtubule polymerization or depolymerization (GO:0031109)2.80576997
126regulation of establishment or maintenance of cell polarity (GO:0032878)2.78233185
127cytoplasmic mRNA processing body assembly (GO:0033962)2.76596250
128cytoskeletal anchoring at plasma membrane (GO:0007016)2.76417164
129negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.74620843
130negative regulation of DNA-templated transcription, elongation (GO:0032785)2.74620843
131mitotic spindle checkpoint (GO:0071174)2.73063758
132mammary gland epithelial cell proliferation (GO:0033598)2.68948940
133keratinocyte proliferation (GO:0043616)2.64170820
134vesicle coating (GO:0006901)2.63038398
135keratinization (GO:0031424)2.62385809
136multicellular organismal water homeostasis (GO:0050891)2.61939642
137keratinocyte differentiation (GO:0030216)2.57591058
138histone H2B ubiquitination (GO:0033523)2.56646182
139ER overload response (GO:0006983)2.54636433
140apical protein localization (GO:0045176)2.54583541
141NLS-bearing protein import into nucleus (GO:0006607)2.53853110
142tight junction assembly (GO:0070830)2.53644289
143trophectodermal cell differentiation (GO:0001829)2.50097480
144cell-cell junction assembly (GO:0007043)2.49274149
145positive regulation of hormone biosynthetic process (GO:0046886)2.48454981
146embryonic camera-type eye morphogenesis (GO:0048596)2.48413254
147activation of Rac GTPase activity (GO:0032863)2.47457139
148branching involved in mammary gland duct morphogenesis (GO:0060444)2.46545288
149regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.43933258
150regulation of NFAT protein import into nucleus (GO:0051532)2.43817495
151hemidesmosome assembly (GO:0031581)2.42887927
152embryonic eye morphogenesis (GO:0048048)2.42737083
153adherens junction assembly (GO:0034333)2.40403199
154planar cell polarity pathway involved in neural tube closure (GO:0090179)2.40071434
155gene silencing by RNA (GO:0031047)2.38922007
156cell-substrate adherens junction assembly (GO:0007045)2.38607971
157focal adhesion assembly (GO:0048041)2.38607971
158pre-miRNA processing (GO:0031054)2.38447265
159embryonic process involved in female pregnancy (GO:0060136)2.37458474
160ectoderm development (GO:0007398)2.35364534
161face development (GO:0060324)2.35242485
162stress granule assembly (GO:0034063)2.33365831
163chondrocyte development (GO:0002063)2.33312666
164polarized epithelial cell differentiation (GO:0030859)2.33141054
165establishment or maintenance of apical/basal cell polarity (GO:0035088)2.32896395
166establishment or maintenance of bipolar cell polarity (GO:0061245)2.32896395
167regulation of keratinocyte differentiation (GO:0045616)2.32657382
168regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.32622007
169regulation of steroid hormone biosynthetic process (GO:0090030)2.32461759
170labyrinthine layer development (GO:0060711)2.31753169
171localization within membrane (GO:0051668)2.31659558
172asymmetric protein localization (GO:0008105)2.31261943
173positive regulation of hormone metabolic process (GO:0032352)2.28878076
174negative regulation of fibroblast apoptotic process (GO:2000270)2.27542029
175regulation of steroid hormone secretion (GO:2000831)2.27180562
176regulation of transforming growth factor beta production (GO:0071634)2.24845435
177RNA stabilization (GO:0043489)2.24572057
178mRNA stabilization (GO:0048255)2.24572057

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.66359000
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.35706928
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.22966367
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.76763461
5TP63_19390658_ChIP-ChIP_HaCaT_Human3.43698525
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.36468373
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.26055283
8TP63_17297297_ChIP-ChIP_HaCaT_Human3.23451161
9* ZNF217_24962896_ChIP-Seq_MCF-7_Human3.17240242
10* ESR1_20079471_ChIP-ChIP_T-47D_Human3.09088715
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.08162657
12E2F4_17652178_ChIP-ChIP_JURKAT_Human3.07891939
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.99315819
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.99207652
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.87745601
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.84291362
17AR_21909140_ChIP-Seq_LNCAP_Human2.73236563
18ESR1_21235772_ChIP-Seq_MCF-7_Human2.60929889
19TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.38932022
20ESR2_21235772_ChIP-Seq_MCF-7_Human2.38018602
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.35970357
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.35937075
23* E2F1_21310950_ChIP-Seq_MCF-7_Human2.26307298
24KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.16883259
25KAP1_22055183_ChIP-Seq_ESCs_Mouse2.15001908
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.12670547
27CLOCK_20551151_ChIP-Seq_293T_Human2.08637641
28FOXO3_23340844_ChIP-Seq_DLD1_Human2.07770840
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.04764819
30AHR_22903824_ChIP-Seq_MCF-7_Human2.03783955
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99513376
32FOXM1_26456572_ChIP-Seq_MCF-7_Human1.95390028
33SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.91207418
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88205701
35SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.88016112
36SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.88016112
37SOX2_27498859_Chip-Seq_STOMACH_Mouse1.85316057
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85169255
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84898248
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.84746637
41PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.78203582
42* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.74854709
43SOX9_24532713_ChIP-Seq_HFSC_Mouse1.70353392
44CTNNB1_20460455_ChIP-Seq_HCT116_Human1.67662760
45IGF1R_20145208_ChIP-Seq_DFB_Human1.65688756
46RNF2_27304074_Chip-Seq_NSC_Mouse1.65074722
47* CHD1_26751641_Chip-Seq_LNCaP_Human1.64938372
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62937650
49GATA3_24758297_ChIP-Seq_MCF-7_Human1.58691546
50ESR1_15608294_ChIP-ChIP_MCF-7_Human1.58647648
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57660338
52PPAR_26484153_Chip-Seq_NCI-H1993_Human1.56915261
53KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.53988885
54KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.53988885
55KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.53988885
56FUS_26573619_Chip-Seq_HEK293_Human1.52388098
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.51133862
58ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.50110014
59* GATA6_25053715_ChIP-Seq_YYC3_Human1.46954925
60CREB1_15753290_ChIP-ChIP_HEK293T_Human1.46179187
61* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.45489007
62MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.44674565
63EP300_21415370_ChIP-Seq_HL-1_Mouse1.44231501
64WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.43848105
65EWS_26573619_Chip-Seq_HEK293_Human1.43608206
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43065598
67KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.42840819
68DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.42719702
69HIF1A_21447827_ChIP-Seq_MCF-7_Human1.42318415
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42022931
71MYCN_18555785_ChIP-Seq_MESCs_Mouse1.41396502
72HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.39325282
73NELFA_20434984_ChIP-Seq_ESCs_Mouse1.38606583
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38529118
75EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.38373298
76* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.37776302
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36790625
78E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36470699
79WT1_19549856_ChIP-ChIP_CCG9911_Human1.35163938
80ZNF263_19887448_ChIP-Seq_K562_Human1.34631603
81FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32822534
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.32021168
83CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.29772511
84EST1_17652178_ChIP-ChIP_JURKAT_Human1.29649621
85* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.27861549
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27655907
87IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.25801716
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.25345879
89SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.24887121
90TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24642538
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.24036401
92* RUNX1_27514584_Chip-Seq_MCF-7_Human1.23263296
93RUNX1_26923725_Chip-Seq_HPCs_Mouse1.23131947
94PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22685808
95YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22045888
96ELK1_19687146_ChIP-ChIP_HELA_Human1.21338023
97ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21149173
98MYC_19079543_ChIP-ChIP_MESCs_Mouse1.20929151
99* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19537134
100CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19519967
101* ELF5_23300383_ChIP-Seq_T47D_Human1.16562463
102SOX2_20726797_ChIP-Seq_SW620_Human1.15375460
103ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14942546
104CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14484917
105PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.14148412
106GATA1_26923725_Chip-Seq_HPCs_Mouse1.13698660
107KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13447923
108TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.13010589
109MYC_18555785_ChIP-Seq_MESCs_Mouse1.12999901
110CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12432794
111GABP_17652178_ChIP-ChIP_JURKAT_Human1.12282544
112FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12051704
113TCF4_18268006_ChIP-ChIP_LS174T_Human1.11643661
114TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10446745
115YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09908397
116* ATF3_27146783_Chip-Seq_COLON_Human1.09345220
117TRIM28_21343339_ChIP-Seq_HEK293_Human1.08649661
118STAT3_18555785_Chip-Seq_ESCs_Mouse1.07621868
119* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.07493424
120CDX2_20551321_ChIP-Seq_CACO-2_Human1.06889621
121HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06597318
122* EZH2_27294783_Chip-Seq_NPCs_Mouse1.05221998
123NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04024868
124MYC_18940864_ChIP-ChIP_HL60_Human1.03878016
125E2F1_18555785_Chip-Seq_ESCs_Mouse1.00657828
126SOX2_18555785_Chip-Seq_ESCs_Mouse1.00508845
127* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.00488850
128SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99689389
129STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99253292
130EGR1_19374776_ChIP-ChIP_THP-1_Human0.98793075
131NMYC_18555785_Chip-Seq_ESCs_Mouse0.98101629
132STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97424534
133LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97072047
134CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96552704
135FOXA2_19822575_ChIP-Seq_HepG2_Human0.96525003
136PKCTHETA_26484144_Chip-Seq_BREAST_Human0.96145062
137GATA4_21415370_ChIP-Seq_HL-1_Mouse0.96035190
138EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95797242
139SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95055352
140CDX2_22108803_ChIP-Seq_LS180_Human0.94882634
141RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94837173
142PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.94808536
143POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94764173
144RACK7_27058665_Chip-Seq_MCF-7_Human0.94724076
145* KDM5A_27292631_Chip-Seq_BREAST_Human0.93804745
146POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93674606
147VDR_23849224_ChIP-Seq_CD4+_Human0.92759933
148FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92524041
149TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91343113
150EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.90938367
151SRF_21415370_ChIP-Seq_HL-1_Mouse0.90293548
152HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.89299122
153RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89227514
154TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89216973
155POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89216973
156ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88884506
157ZFX_18555785_Chip-Seq_ESCs_Mouse0.87470873
158DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86648154
159OCT4_18555785_Chip-Seq_ESCs_Mouse0.86214557
160CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.86119682
161MYC_19030024_ChIP-ChIP_MESCs_Mouse0.85587166
162* POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85402435
163P53_22387025_ChIP-Seq_ESCs_Mouse0.85356818
164CMYC_18555785_Chip-Seq_ESCs_Mouse0.84737678
165NOTCH1_21737748_ChIP-Seq_TLL_Human0.84494227
166BRD4_25478319_ChIP-Seq_HGPS_Human0.84097186
167GF1B_26923725_Chip-Seq_HPCs_Mouse0.83914371
168ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.82915762
169* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82566437
170SALL4_18804426_ChIP-ChIP_XEN_Mouse0.81849984
171STAT3_23295773_ChIP-Seq_U87_Human0.81679342

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.12841715
2MP0002796_impaired_skin_barrier3.86876851
3MP0008877_abnormal_DNA_methylation3.83833719
4MP0003693_abnormal_embryo_hatching3.68569631
5MP0010352_gastrointestinal_tract_polyps3.60588748
6MP0008057_abnormal_DNA_replication3.24053675
7MP0008007_abnormal_cellular_replicative3.13712046
8MP0010094_abnormal_chromosome_stability3.05138502
9MP0003077_abnormal_cell_cycle3.02988479
10MP0000566_synostosis3.02909154
11MP0003787_abnormal_imprinting2.78952106
12MP0003111_abnormal_nucleus_morphology2.71101499
13MP0003705_abnormal_hypodermis_morpholog2.55520704
14MP0005501_abnormal_skin_physiology2.53665016
15MP0008058_abnormal_DNA_repair2.53600168
16MP0005451_abnormal_body_composition2.52076622
17MP0003123_paternal_imprinting2.50764532
18MP0003718_maternal_effect2.49723335
19MP0006292_abnormal_olfactory_placode2.44505357
20MP0002163_abnormal_gland_morphology2.36594227
21MP0003121_genomic_imprinting2.32458676
22MP0010678_abnormal_skin_adnexa2.32199703
23MP0005408_hypopigmentation2.19030936
24MP0005275_abnormal_skin_tensile2.17654372
25MP0002877_abnormal_melanocyte_morpholog2.11331843
26MP0003566_abnormal_cell_adhesion2.04192245
27MP0001119_abnormal_female_reproductive2.00302935
28MP0004957_abnormal_blastocyst_morpholog1.99354570
29MP0001346_abnormal_lacrimal_gland1.94029107
30MP0002102_abnormal_ear_morphology1.88942433
31MP0003937_abnormal_limbs/digits/tail_de1.87087230
32MP0002210_abnormal_sex_determination1.84218948
33MP0009780_abnormal_chondrocyte_physiolo1.81413291
34MP0004233_abnormal_muscle_weight1.79114972
35MP0008789_abnormal_olfactory_epithelium1.75909211
36MP0003941_abnormal_skin_development1.74066945
37MP0000350_abnormal_cell_proliferation1.73160469
38MP0000762_abnormal_tongue_morphology1.71673593
39MP0005409_darkened_coat_color1.70755335
40MP0000579_abnormal_nail_morphology1.69438111
41MP0003890_abnormal_embryonic-extraembry1.68075094
42MP0003786_premature_aging1.64915154
43MP0002098_abnormal_vibrissa_morphology1.61921312
44MP0000383_abnormal_hair_follicle1.59863096
45MP0003453_abnormal_keratinocyte_physiol1.59599713
46MP0010030_abnormal_orbit_morphology1.59050259
47MP0008932_abnormal_embryonic_tissue1.56805628
48MP0010307_abnormal_tumor_latency1.54689795
49MP0002060_abnormal_skin_morphology1.52688499
50MP0003315_abnormal_perineum_morphology1.51813038
51MP0001216_abnormal_epidermal_layer1.51158562
52MP0000377_abnormal_hair_follicle1.50845045
53MP0000653_abnormal_sex_gland1.50540098
54MP0008995_early_reproductive_senescence1.46586322
55MP0009250_abnormal_appendicular_skeleto1.43809267
56MP0009053_abnormal_anal_canal1.42309900
57MP0002160_abnormal_reproductive_system1.37766281
58MP0003183_abnormal_peptide_metabolism1.36864986
59MP0001929_abnormal_gametogenesis1.36284681
60MP0003950_abnormal_plasma_membrane1.36271950
61MP0000537_abnormal_urethra_morphology1.36151806
62MP0001730_embryonic_growth_arrest1.35871711
63MP0003755_abnormal_palate_morphology1.35606452
64MP0001672_abnormal_embryogenesis/_devel1.34033675
65MP0005380_embryogenesis_phenotype1.34033675
66MP0000516_abnormal_urinary_system1.33982509
67MP0005367_renal/urinary_system_phenotyp1.33982509
68MP0000462_abnormal_digestive_system1.32728440
69MP0003385_abnormal_body_wall1.32687608
70MP0004185_abnormal_adipocyte_glucose1.32111079
71MP0002009_preneoplasia1.31880762
72MP0003646_muscle_fatigue1.30599619
73MP0001145_abnormal_male_reproductive1.30570027
74MP0000427_abnormal_hair_cycle1.27209205
75MP0002085_abnormal_embryonic_tissue1.26821531
76MP0001697_abnormal_embryo_size1.26397080
77MP0004782_abnormal_surfactant_physiolog1.25796379
78MP0003699_abnormal_female_reproductive1.25451615
79MP0003943_abnormal_hepatobiliary_system1.23238510
80MP0005499_abnormal_olfactory_system1.21927158
81MP0005394_taste/olfaction_phenotype1.21927158
82MP0001881_abnormal_mammary_gland1.21763973
83MP0003984_embryonic_growth_retardation1.21232662
84MP0010771_integument_phenotype1.21161252
85MP0002249_abnormal_larynx_morphology1.17506329
86MP0002233_abnormal_nose_morphology1.14122351
87MP0002088_abnormal_embryonic_growth/wei1.13869047
88MP0002653_abnormal_ependyma_morphology1.13716505
89MP0005395_other_phenotype1.12289707
90MP0005248_abnormal_Harderian_gland1.11638653
91MP0003868_abnormal_feces_composition1.11127856
92MP0002896_abnormal_bone_mineralization1.10292024
93MP0002084_abnormal_developmental_patter1.09687984
94MP0003091_abnormal_cell_migration1.09523902
95MP0005310_abnormal_salivary_gland1.08733920
96MP0002396_abnormal_hematopoietic_system1.07922282
97MP0005379_endocrine/exocrine_gland_phen1.06766865
98MP0000678_abnormal_parathyroid_gland1.05484521
99MP0000428_abnormal_craniofacial_morphol1.04549008
100MP0005257_abnormal_intraocular_pressure1.02977400
101MP0004264_abnormal_extraembryonic_tissu1.02706771
102MP0005023_abnormal_wound_healing1.00057511
103MP0002938_white_spotting0.98969412
104MP0004197_abnormal_fetal_growth/weight/0.98869967
105MP0005389_reproductive_system_phenotype0.97682094
106MP0002697_abnormal_eye_size0.97386989
107MP0001666_abnormal_nutrient_absorption0.96342238
108MP0005646_abnormal_pituitary_gland0.95805044
109MP0002080_prenatal_lethality0.95474149
110MP0000432_abnormal_head_morphology0.94564862
111MP0003942_abnormal_urinary_system0.93845058
112MP0001849_ear_inflammation0.93411233
113MP0004272_abnormal_basement_membrane0.93362547
114MP0009703_decreased_birth_body0.92643295
115MP0009697_abnormal_copulation0.91516770
116MP0003936_abnormal_reproductive_system0.91350687
117MP0000569_abnormal_digit_pigmentation0.89196597
118MP0002086_abnormal_extraembryonic_tissu0.88896200
119MP0001915_intracranial_hemorrhage0.88797023
120MP0005621_abnormal_cell_physiology0.88596160
121MP0000627_abnormal_mammary_gland0.87649715
122MP0008438_abnormal_cutaneous_collagen0.85699853
123MP0004808_abnormal_hematopoietic_stem0.85645916
124MP0008004_abnormal_stomach_pH0.85451132
125MP0010386_abnormal_urinary_bladder0.84873530
126MP0010368_abnormal_lymphatic_system0.84807305
127MP0001286_abnormal_eye_development0.84029012
128MP0001177_atelectasis0.83935451
129MP0000467_abnormal_esophagus_morphology0.81717466
130MP0002277_abnormal_respiratory_mucosa0.81483863
131MP0002109_abnormal_limb_morphology0.80504368
132MP0001919_abnormal_reproductive_system0.79067606
133MP0005076_abnormal_cell_differentiation0.78735180
134MP0002177_abnormal_outer_ear0.78684385
135MP0003935_abnormal_craniofacial_develop0.78118493
136MP0000613_abnormal_salivary_gland0.76370613
137MP0001340_abnormal_eyelid_morphology0.75396879
138MP0001188_hyperpigmentation0.74850419
139MP0000313_abnormal_cell_death0.74608322
140MP0002116_abnormal_craniofacial_bone0.73532522
141MP0005666_abnormal_adipose_tissue0.73145626
142MP0005508_abnormal_skeleton_morphology0.72757843
143MP0000767_abnormal_smooth_muscle0.72569824
144MP0002254_reproductive_system_inflammat0.72274011
145MP0002019_abnormal_tumor_incidence0.71274468
146MP0009672_abnormal_birth_weight0.70829749
147MP0003115_abnormal_respiratory_system0.69961809
148MP0001191_abnormal_skin_condition0.68679761
149MP0000733_abnormal_muscle_development0.68287448
150MP0005503_abnormal_tendon_morphology0.67818222
151MP0005397_hematopoietic_system_phenotyp0.67442950

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.23802167
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.05247005
3Right ventricular cardiomyopathy (HP:0011663)4.33050558
4Patellar aplasia (HP:0006443)3.88161807
5Birth length less than 3rd percentile (HP:0003561)3.83172460
6Ectopic kidney (HP:0000086)3.73926239
7Abnormality of the fingertips (HP:0001211)3.64452488
8Aplasia/Hypoplasia of the patella (HP:0006498)3.62944423
9Shawl scrotum (HP:0000049)3.62800031
10Lip pit (HP:0100267)3.60830101
11Prostate neoplasm (HP:0100787)3.58267804
12Adrenal hypoplasia (HP:0000835)3.50182811
13Capillary hemangiomas (HP:0005306)3.42267249
14Acute myeloid leukemia (HP:0004808)3.18784611
15Flat capital femoral epiphysis (HP:0003370)3.15381931
16Abnormality of the labia minora (HP:0012880)3.15092385
17* Papillary thyroid carcinoma (HP:0002895)3.14710819
18Meckel diverticulum (HP:0002245)3.14281498
19Abnormality of chromosome stability (HP:0003220)3.12818777
20Aplasia/Hypoplasia of the uvula (HP:0010293)3.01073648
21Facial hemangioma (HP:0000329)2.97047033
22Abnormality of the ileum (HP:0001549)2.91344426
23Nephroblastoma (Wilms tumor) (HP:0002667)2.83444836
24Azoospermia (HP:0000027)2.83287334
25Abnormality of the preputium (HP:0100587)2.81466071
26Breast hypoplasia (HP:0003187)2.80588148
27Embryonal renal neoplasm (HP:0011794)2.72226623
28Flat acetabular roof (HP:0003180)2.72038368
29Cystic hygroma (HP:0000476)2.66921013
30Abnormality of incisor morphology (HP:0011063)2.63988134
31Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.54748979
32Abnormality of the phalanges of the hallux (HP:0010057)2.54350154
33Breast aplasia (HP:0100783)2.53857281
34Relative macrocephaly (HP:0004482)2.52129337
35Abnormal spermatogenesis (HP:0008669)2.50179436
36Septate vagina (HP:0001153)2.46653995
37Spinal cord compression (HP:0002176)2.42355177
38* Thyroid carcinoma (HP:0002890)2.39160289
39Aplasia/Hypoplasia of the breasts (HP:0010311)2.38842948
40Abnormal lung lobation (HP:0002101)2.38745708
41Clubbing of toes (HP:0100760)2.37471553
42Pancreatic fibrosis (HP:0100732)2.36976120
43Intestinal fistula (HP:0100819)2.36265923
44Abnormal hair whorl (HP:0010721)2.35525157
45Pili torti (HP:0003777)2.34894917
46Selective tooth agenesis (HP:0001592)2.32884421
47Abnormality of the salivary glands (HP:0010286)2.32187664
48Male infertility (HP:0003251)2.31199392
49Abnormality of nail color (HP:0100643)2.27607846
50Ankyloglossia (HP:0010296)2.26711390
51Hypoplastic labia majora (HP:0000059)2.25704694
52Insidious onset (HP:0003587)2.25669219
53Termporal pattern (HP:0011008)2.25669219
54Myelodysplasia (HP:0002863)2.25328981
55Small intestinal stenosis (HP:0012848)2.23811250
56Duodenal stenosis (HP:0100867)2.23811250
57Abnormality of the aortic arch (HP:0012303)2.23801108
58Advanced eruption of teeth (HP:0006288)2.23475664
59True hermaphroditism (HP:0010459)2.21436898
60Impulsivity (HP:0100710)2.18400101
61Osteolytic defects of the hand bones (HP:0009699)2.17578157
62Osteolytic defects of the phalanges of the hand (HP:0009771)2.17578157
63Aplasia/Hypoplasia of the sternum (HP:0006714)2.17283044
64Absent eyebrow (HP:0002223)2.16734739
65Abnormality of the intervertebral disk (HP:0005108)2.16458668
66Overgrowth (HP:0001548)2.12672404
67Abnormality of chromosome segregation (HP:0002916)2.11379784
68Deep philtrum (HP:0002002)2.09924767
69Vertebral arch anomaly (HP:0008438)2.09761066
70Carpal bone hypoplasia (HP:0001498)2.09253854
71Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.07705435
72Abnormality of the nasal septum (HP:0000419)2.07270392
73Uterine leiomyosarcoma (HP:0002891)2.06872465
74Leiomyosarcoma (HP:0100243)2.06872465
75Large earlobe (HP:0009748)2.05320975
76Asymmetry of the thorax (HP:0001555)2.05065651
77Curly hair (HP:0002212)2.04793245
78Degeneration of anterior horn cells (HP:0002398)2.00329769
79Abnormality of the anterior horn cell (HP:0006802)2.00329769
80Gastrointestinal carcinoma (HP:0002672)1.98306229
81Malignant gastrointestinal tract tumors (HP:0006749)1.98306229
82Deviation of the thumb (HP:0009603)1.97454817
83Increased nuchal translucency (HP:0010880)1.96803083
84Urethral obstruction (HP:0000796)1.96313818
85Macroorchidism (HP:0000053)1.96217971
86Supernumerary spleens (HP:0009799)1.95960583
87Heterotopia (HP:0002282)1.95603332
88Dysmetric saccades (HP:0000641)1.95486372
89Short thumb (HP:0009778)1.95444941
90Sandal gap (HP:0001852)1.95374666
91Spinal cord lesions (HP:0100561)1.95235806
92Syringomyelia (HP:0003396)1.95235806
93Cubitus valgus (HP:0002967)1.94963861
94Absent frontal sinuses (HP:0002688)1.94772391
95Abnormality of the labia majora (HP:0012881)1.92780794
96Abnormality of the dental root (HP:0006486)1.92630762
97Taurodontia (HP:0000679)1.92630762
98Abnormality of permanent molar morphology (HP:0011071)1.92630762
99Transitional cell carcinoma of the bladder (HP:0006740)1.91979349
100Neoplasm of the tracheobronchial system (HP:0100552)1.91926170
101Absent eyelashes (HP:0000561)1.91746750
102Absent radius (HP:0003974)1.91493479
103Midline defect of the nose (HP:0004122)1.90451015
104Aplasia/Hypoplasia of the fovea (HP:0008060)1.90319967
105Hypoplasia of the fovea (HP:0007750)1.90319967
106Microglossia (HP:0000171)1.89915171
107Periauricular skin pits (HP:0100277)1.89689080
108Preauricular pit (HP:0004467)1.89689080
109Abnormality of the carotid arteries (HP:0005344)1.88367668
110Renal cell carcinoma (HP:0005584)1.87352713
111Subacute progressive viral hepatitis (HP:0006572)1.86704057
112Arterial tortuosity (HP:0005116)1.85877334
113Cutaneous melanoma (HP:0012056)1.85166566
114Autoimmune thrombocytopenia (HP:0001973)1.84941890
115Abnormality of the distal phalanx of the thumb (HP:0009617)1.84855793
116Abnormality of molar morphology (HP:0011070)1.84819135
117Abnormality of molar (HP:0011077)1.84819135
118Breast carcinoma (HP:0003002)1.84656928
119Biliary tract neoplasm (HP:0100574)1.84261535
120Abnormality of the epiphysis of the femoral head (HP:0010574)1.82392626
121Abnormality of the duodenum (HP:0002246)1.82132395
122Abnormality of the femoral head (HP:0003368)1.80391935
123Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.79289971
124Hypotrichosis (HP:0001006)1.78555480
125Hypoplasia of dental enamel (HP:0006297)1.78335478
126Hypoplastic iliac wings (HP:0002866)1.78237110
127Poor coordination (HP:0002370)1.77787287
128Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.77422445
129Alopecia of scalp (HP:0002293)1.75663524
130Absent forearm bone (HP:0003953)1.75629048
131Aplasia involving forearm bones (HP:0009822)1.75629048
132Natal tooth (HP:0000695)1.74815272
133Abnormality of the gastric mucosa (HP:0004295)1.74744891
134Pancreatic cysts (HP:0001737)1.74046241
135Sloping forehead (HP:0000340)1.73978724
136Alveolar cell carcinoma (HP:0006519)1.73719691
137Osteomalacia (HP:0002749)1.73521752
138Bladder neoplasm (HP:0009725)1.73379306
139Bladder carcinoma (HP:0002862)1.73379306
140Vascular tortuosity (HP:0004948)1.71899909
141Long eyelashes (HP:0000527)1.71841327
142Optic nerve coloboma (HP:0000588)1.71627637
143Germ cell neoplasia (HP:0100728)1.71557096
144Cranial hyperostosis (HP:0004437)1.70912744
145Cafe-au-lait spot (HP:0000957)1.70750319
146Abnormality of the prostate (HP:0008775)1.70540392
147Proximal placement of thumb (HP:0009623)1.69068359
148Sparse lateral eyebrow (HP:0005338)1.68675264
149Abnormality of femoral epiphyses (HP:0006499)1.68329424
150Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.68329424
151Neoplasm of the adrenal cortex (HP:0100641)1.65521507
152Aplasia/Hypoplasia of the tongue (HP:0010295)1.65215873
153Abnormality of oral frenula (HP:0000190)1.63420910
154Embryonal neoplasm (HP:0002898)1.62300763
155Type 2 muscle fiber atrophy (HP:0003554)1.61721883
156Abnormality of male internal genitalia (HP:0000022)1.61718472
157Chorioretinal coloboma (HP:0000567)1.61652831
158Abnormality of the renal collecting system (HP:0004742)1.61492495
159Abnormality of the fovea (HP:0000493)1.60906131
160Enlarged penis (HP:0000040)1.60642530
161Preaxial hand polydactyly (HP:0001177)1.59779781
162Congenital ichthyosiform erythroderma (HP:0007431)1.59547525
163Uterine neoplasm (HP:0010784)1.59501231
164Abnormality of the dental pulp (HP:0006479)1.59090192
165Hypophosphatemic rickets (HP:0004912)1.58865664
166Renal hypoplasia (HP:0000089)1.58834734
167Rhabdomyosarcoma (HP:0002859)1.58473940
168Craniofacial hyperostosis (HP:0004493)1.57559937
169Overlapping toe (HP:0001845)1.56425740
170Shallow orbits (HP:0000586)1.56400740
171Volvulus (HP:0002580)1.54238346
172Abnormality of the parietal bone (HP:0002696)1.53563684
173Abnormality of calcium-phosphate metabolism (HP:0100530)1.53514103
174Hypoplastic scapulae (HP:0000882)1.52213630
175Aplasia/Hypoplasia of the scapulae (HP:0006713)1.52213630
176Aplasia involving bones of the upper limbs (HP:0009823)1.51529949
177Aplasia of the phalanges of the hand (HP:0009802)1.51529949
178Aplasia involving bones of the extremities (HP:0009825)1.51529949
179Abnormality of the distal phalanges of the toes (HP:0010182)1.51274228
180Hydroureter (HP:0000072)1.51256259
181Unilateral renal agenesis (HP:0000122)1.50998239
182Micronodular cirrhosis (HP:0001413)1.50205896

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK38L6.66822298
2LATS16.03960582
3LATS24.44792105
4MAP3K93.52529837
5PLK43.43558225
6CDC73.18689965
7STK242.70082395
8STK32.63737550
9EPHA22.60264849
10MET2.41985018
11MST42.24557443
12ERBB42.15465534
13SRPK12.10948382
14AKT32.07723839
15EEF2K1.99734014
16SCYL21.95127384
17SMG11.92333860
18CAMK1G1.92273648
19CAMK1D1.90685693
20CDK81.90663472
21PBK1.90277693
22MST1R1.89115018
23NUAK11.82356771
24ICK1.78557901
25TAF11.77067876
26MAP3K61.76407722
27ZAK1.75852086
28BRAF1.69648562
29CDK121.67173957
30CHEK21.66344765
31BRSK21.65184093
32PTK21.64166358
33TRIB31.62913855
34PLK31.54268721
35MAP3K131.46352176
36BMPR21.45658513
37PLK21.42582981
38TTK1.40802076
39ACVR1B1.38220155
40TSSK61.37187424
41SGK21.36061361
42RPS6KB21.30866331
43RIPK11.30099714
44PDGFRA1.24659375
45MTOR1.24471896
46PLK11.24062568
47TAOK11.23174514
48SIK11.22600934
49FRK1.18816790
50STK381.18384427
51MAP2K71.16343434
52VRK11.09095124
53NEK21.08938574
54ERBB31.08816777
55NEK91.07704502
56MAP3K141.05790300
57ABL21.04988292
58MAP3K21.04682252
59MAP3K101.04663721
60PRKD31.03912364
61PKN21.02633976
62BRSK10.98147642
63TNIK0.98105161
64JAK30.96060124
65MELK0.94994000
66CHUK0.93027624
67MAPK130.90960504
68STK390.90649644
69MAP3K40.89206475
70MAP3K120.85343401
71MUSK0.84705512
72RAF10.84658958
73AURKB0.83585855
74TRPM70.83482618
75WNK10.83108954
76DYRK20.81886111
77KSR20.81107742
78NTRK10.79430277
79* CHEK10.79360808
80NEK60.79206917
81PNCK0.78206523
82* ATM0.75585426
83BUB10.75385402
84MKNK20.72622436
85SGK30.71723623
86ATR0.71321016
87PAK40.70765203
88EIF2AK20.68606827
89PAK20.67667062
90CDK60.64813647
91SIK30.64548475
92PIM10.64347715
93SGK4940.64211094
94SGK2230.64211094
95LMTK20.62424192
96MKNK10.62156046
97STK40.61023496
98BCR0.60954359
99TAOK30.60917750
100FER0.60287498
101CDK70.59389208
102IRAK30.57867143
103BMPR1B0.57104670
104FGFR10.56981683
105CDK30.56767477
106PDGFRB0.55011134
107DMPK0.54164420
108EIF2AK10.51878536
109CSNK1E0.51429779
110LRRK20.50683534
111OBSCN0.48986078
112* CDK20.48618650
113MAP3K50.47987019
114CDK90.47755200
115PRKAA10.47657859
116CDK10.47446301
117AURKA0.44051653
118IKBKB0.41468857
119MAP3K30.38476810
120ARAF0.37802840
121AKT20.37678207
122NEK10.37591409
123TGFBR10.37080172
124TRIM280.36624651
125RPS6KB10.36064282
126PIK3CA0.35372765
127AKT10.34566081
128KSR10.33570511
129ABL10.33224161
130TESK10.32989529
131TAOK20.32945607
132EIF2AK30.29956537
133IKBKE0.29690692
134MAPK140.29319153
135BRD40.28844053
136PRKCI0.28222893
137EPHB20.26066802
138PRPF4B0.24270875
139MARK30.22564006
140NLK0.22069995
141RPS6KA40.21140751
142PRKD20.21130005
143WEE10.19672020
144YES10.19597888
145MAP3K80.18622479
146PAK60.18028929

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030224.07822846
2Cell cycle_Homo sapiens_hsa041103.65158731
3RNA degradation_Homo sapiens_hsa030183.13696660
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.05222999
5RNA polymerase_Homo sapiens_hsa030203.00321504
6Homologous recombination_Homo sapiens_hsa034402.96680365
7Fanconi anemia pathway_Homo sapiens_hsa034602.94645875
8RNA transport_Homo sapiens_hsa030132.45133841
9p53 signaling pathway_Homo sapiens_hsa041152.36671611
10Base excision repair_Homo sapiens_hsa034102.10151397
11Mismatch repair_Homo sapiens_hsa034302.03777921
12Non-homologous end-joining_Homo sapiens_hsa034501.99488758
13mRNA surveillance pathway_Homo sapiens_hsa030151.86708471
14TGF-beta signaling pathway_Homo sapiens_hsa043501.80659940
15DNA replication_Homo sapiens_hsa030301.79237042
16Herpes simplex infection_Homo sapiens_hsa051681.66164286
17Nucleotide excision repair_Homo sapiens_hsa034201.64070264
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.52870713
19MicroRNAs in cancer_Homo sapiens_hsa052061.52446363
20Pancreatic cancer_Homo sapiens_hsa052121.50719152
21Proteoglycans in cancer_Homo sapiens_hsa052051.44708298
22Prolactin signaling pathway_Homo sapiens_hsa049171.40225451
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.39992371
24Endometrial cancer_Homo sapiens_hsa052131.38219962
25Dorso-ventral axis formation_Homo sapiens_hsa043201.37293924
26Influenza A_Homo sapiens_hsa051641.32742676
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.32497036
28One carbon pool by folate_Homo sapiens_hsa006701.30470729
29Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.30122595
30Steroid biosynthesis_Homo sapiens_hsa001001.29196927
31Oocyte meiosis_Homo sapiens_hsa041141.26458783
32Spliceosome_Homo sapiens_hsa030401.25901394
33Adherens junction_Homo sapiens_hsa045201.25888191
34Inositol phosphate metabolism_Homo sapiens_hsa005621.24594594
35Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.22881284
36Central carbon metabolism in cancer_Homo sapiens_hsa052301.22071989
37Pyrimidine metabolism_Homo sapiens_hsa002401.20962977
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.20223347
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18880657
40Focal adhesion_Homo sapiens_hsa045101.17416934
41Circadian rhythm_Homo sapiens_hsa047101.17303483
42Glioma_Homo sapiens_hsa052141.16764845
43Hippo signaling pathway_Homo sapiens_hsa043901.14942916
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.13337638
45Autoimmune thyroid disease_Homo sapiens_hsa053201.11746543
46Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.11080301
47Prostate cancer_Homo sapiens_hsa052151.10812525
48Epstein-Barr virus infection_Homo sapiens_hsa051691.08807712
49Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.07417744
50Purine metabolism_Homo sapiens_hsa002301.05275369
51Insulin signaling pathway_Homo sapiens_hsa049101.05082156
52Long-term potentiation_Homo sapiens_hsa047201.04782829
53Gap junction_Homo sapiens_hsa045401.04538620
54Intestinal immune network for IgA production_Homo sapiens_hsa046721.04429140
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.04342212
56Colorectal cancer_Homo sapiens_hsa052101.02511186
57Allograft rejection_Homo sapiens_hsa053301.02428851
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00061555
59FoxO signaling pathway_Homo sapiens_hsa040680.97089678
60Estrogen signaling pathway_Homo sapiens_hsa049150.96459090
61ECM-receptor interaction_Homo sapiens_hsa045120.95139188
62Small cell lung cancer_Homo sapiens_hsa052220.92745592
63HTLV-I infection_Homo sapiens_hsa051660.91976877
64AMPK signaling pathway_Homo sapiens_hsa041520.89376555
65Ovarian steroidogenesis_Homo sapiens_hsa049130.88558143
66Hepatitis B_Homo sapiens_hsa051610.87590133
67Viral myocarditis_Homo sapiens_hsa054160.86500057
68Melanoma_Homo sapiens_hsa052180.85544336
69Measles_Homo sapiens_hsa051620.85542223
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.85540487
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85467503
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.82067314
73Vitamin B6 metabolism_Homo sapiens_hsa007500.79833963
74Proteasome_Homo sapiens_hsa030500.79320401
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.78708714
76Amoebiasis_Homo sapiens_hsa051460.78350620
77Protein export_Homo sapiens_hsa030600.78107230
78Melanogenesis_Homo sapiens_hsa049160.73849909
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.73019443
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72995718
81Arachidonic acid metabolism_Homo sapiens_hsa005900.72917382
82TNF signaling pathway_Homo sapiens_hsa046680.72725816
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.72309552
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71902822
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.70935868
86VEGF signaling pathway_Homo sapiens_hsa043700.70857064
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70758430
88Graft-versus-host disease_Homo sapiens_hsa053320.70718504
89Viral carcinogenesis_Homo sapiens_hsa052030.70355576
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68826095
91Pancreatic secretion_Homo sapiens_hsa049720.67863531
92Glucagon signaling pathway_Homo sapiens_hsa049220.66811899
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64632180
94Selenocompound metabolism_Homo sapiens_hsa004500.63575758
95Lysine degradation_Homo sapiens_hsa003100.63345049
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63042077
97Vibrio cholerae infection_Homo sapiens_hsa051100.62435030
98Chronic myeloid leukemia_Homo sapiens_hsa052200.61044938
99Insulin resistance_Homo sapiens_hsa049310.60866052
100ErbB signaling pathway_Homo sapiens_hsa040120.60684598
101Thyroid hormone synthesis_Homo sapiens_hsa049180.58074695
102Long-term depression_Homo sapiens_hsa047300.57828302
103Non-small cell lung cancer_Homo sapiens_hsa052230.56197334
104RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55704224
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55472050
106Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55421870
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55301079
108Shigellosis_Homo sapiens_hsa051310.55188406
109cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55000863
110Vitamin digestion and absorption_Homo sapiens_hsa049770.54721663
111Apoptosis_Homo sapiens_hsa042100.54378075
112GnRH signaling pathway_Homo sapiens_hsa049120.54016318
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52578071
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.52227080
115Toxoplasmosis_Homo sapiens_hsa051450.51598539
116Wnt signaling pathway_Homo sapiens_hsa043100.51146842
117Basal cell carcinoma_Homo sapiens_hsa052170.50945393
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50418332
119Type I diabetes mellitus_Homo sapiens_hsa049400.50243823
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50177807
121Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48519847
122* Pathways in cancer_Homo sapiens_hsa052000.47880273
123Notch signaling pathway_Homo sapiens_hsa043300.47540952
124* Thyroid cancer_Homo sapiens_hsa052160.47153290
125Linoleic acid metabolism_Homo sapiens_hsa005910.47005085
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46017459
127Sphingolipid metabolism_Homo sapiens_hsa006000.45380573
128Tight junction_Homo sapiens_hsa045300.44461775
129Renal cell carcinoma_Homo sapiens_hsa052110.43252169
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40436318
131Hepatitis C_Homo sapiens_hsa051600.38004905
132Ras signaling pathway_Homo sapiens_hsa040140.37855269
133Acute myeloid leukemia_Homo sapiens_hsa052210.36155290
134Ether lipid metabolism_Homo sapiens_hsa005650.35466442
135Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34938701
136Choline metabolism in cancer_Homo sapiens_hsa052310.33113325
137mTOR signaling pathway_Homo sapiens_hsa041500.32722082
138Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32354506
139Chemokine signaling pathway_Homo sapiens_hsa040620.31846703
140Rheumatoid arthritis_Homo sapiens_hsa053230.31480903
141Pentose phosphate pathway_Homo sapiens_hsa000300.29490881
142Bladder cancer_Homo sapiens_hsa052190.28981573
143Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27408775
144Hedgehog signaling pathway_Homo sapiens_hsa043400.27301277
145Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27073992
146PI3K-Akt signaling pathway_Homo sapiens_hsa041510.26969555

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