CCDC63

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromosome condensation (GO:0030261)9.04146086
2DNA packaging (GO:0006323)8.64690132
3rRNA methylation (GO:0031167)7.29328799
4spermatid nucleus differentiation (GO:0007289)7.14536888
5protein polyglutamylation (GO:0018095)6.43804473
6rRNA modification (GO:0000154)6.39811623
7sexual reproduction (GO:0019953)6.31387000
8protein targeting to Golgi (GO:0000042)5.99631358
9calcium ion-dependent exocytosis (GO:0017156)5.96578734
10establishment of protein localization to Golgi (GO:0072600)5.80700664
11phosphatidylethanolamine biosynthetic process (GO:0006646)5.78209058
12negative regulation of inclusion body assembly (GO:0090084)5.76147947
13retrograde transport, vesicle recycling within Golgi (GO:0000301)5.60288099
14chromatin silencing (GO:0006342)5.45274067
15motile cilium assembly (GO:0044458)5.34726016
16microtubule severing (GO:0051013)5.28634397
17phosphatidylethanolamine metabolic process (GO:0046337)5.20971360
18sperm motility (GO:0030317)5.06324227
19regulation of centriole replication (GO:0046599)5.01506185
20multicellular organism reproduction (GO:0032504)4.99567522
21axonemal dynein complex assembly (GO:0070286)4.99317306
22cell wall macromolecule metabolic process (GO:0044036)4.92091783
23cell wall macromolecule catabolic process (GO:0016998)4.92091783
24fusion of sperm to egg plasma membrane (GO:0007342)4.91270710
25seminiferous tubule development (GO:0072520)4.85706640
26positive regulation of Rab GTPase activity (GO:0032851)4.83380144
27regulation of Rab GTPase activity (GO:0032313)4.83380144
28cilium or flagellum-dependent cell motility (GO:0001539)4.76408764
29acrosome reaction (GO:0007340)4.74579211
30germ cell development (GO:0007281)4.52035127
31protein localization to Golgi apparatus (GO:0034067)4.45315827
32cellular ketone body metabolic process (GO:0046950)4.43052659
33sperm-egg recognition (GO:0035036)4.39993841
34multicellular organismal reproductive process (GO:0048609)4.32182591
35epithelial cilium movement (GO:0003351)4.31521033
36microtubule depolymerization (GO:0007019)4.25062060
37regulation of transcription involved in cell fate commitment (GO:0060850)4.20857664
38cellular process involved in reproduction in multicellular organism (GO:0022412)4.12749652
39coenzyme catabolic process (GO:0009109)4.00741086
40regulation of inclusion body assembly (GO:0090083)4.00627949
41antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.98093329
42cell-cell recognition (GO:0009988)3.98082760
43acrosome assembly (GO:0001675)3.97608450
44centriole assembly (GO:0098534)3.96572468
45regulation of cilium movement (GO:0003352)3.93504139
46multicellular organismal movement (GO:0050879)3.89985845
47musculoskeletal movement (GO:0050881)3.89985845
48ketone body metabolic process (GO:1902224)3.86928403
49binding of sperm to zona pellucida (GO:0007339)3.86497386
50DNA deamination (GO:0045006)3.85398619
51reproduction (GO:0000003)3.80482119
52protein-DNA complex disassembly (GO:0032986)3.72307953
53nucleosome disassembly (GO:0006337)3.72307953
54nucleus organization (GO:0006997)3.69313782
55epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.67879587
56plasma membrane fusion (GO:0045026)3.65262476
57spermatid development (GO:0007286)3.62993309
58RNA destabilization (GO:0050779)3.58582240
59negative regulation of gene expression, epigenetic (GO:0045814)3.57192186
60cilium movement (GO:0003341)3.49258105
61superoxide anion generation (GO:0042554)3.47506654
62glycerol ether metabolic process (GO:0006662)3.40447064
63organic cation transport (GO:0015695)3.38514415
64single fertilization (GO:0007338)3.35419899
65piRNA metabolic process (GO:0034587)3.31375515
66peptidyl-threonine dephosphorylation (GO:0035970)3.29201951
67regulation of interleukin-13 production (GO:0032656)3.27423556
68cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.23231340
69regulation of somitogenesis (GO:0014807)3.19855341
70centriole replication (GO:0007099)3.12787010
71ether metabolic process (GO:0018904)3.11439549
72polyketide metabolic process (GO:0030638)3.09928235
73doxorubicin metabolic process (GO:0044598)3.09928235
74daunorubicin metabolic process (GO:0044597)3.09928235
75DNA methylation involved in gamete generation (GO:0043046)3.07680710
76positive regulation of action potential (GO:0045760)3.04796754
77histone exchange (GO:0043486)3.04383895
78male meiosis (GO:0007140)3.03070841
79polyamine biosynthetic process (GO:0006596)3.00315453
80response to peptidoglycan (GO:0032494)2.94380250
81embryonic skeletal joint morphogenesis (GO:0060272)2.93419011
82DNA conformation change (GO:0071103)2.92440088
83proteasome assembly (GO:0043248)2.90744371
84response to acidic pH (GO:0010447)2.90393816
85positive regulation of skeletal muscle tissue development (GO:0048643)2.88912443
86single strand break repair (GO:0000012)2.88595283
87cerebral cortex neuron differentiation (GO:0021895)2.87931697
88negative regulation of Rho protein signal transduction (GO:0035024)2.87894345
89gene silencing (GO:0016458)2.86857906
90multicellular organismal development (GO:0007275)2.86284970
91negative regulation of mast cell activation (GO:0033004)2.85604134
92synapsis (GO:0007129)2.84888528
93outflow tract septum morphogenesis (GO:0003148)2.83446820
94cellular response to pH (GO:0071467)2.83006564
95microtubule nucleation (GO:0007020)2.78157632
96regulation of microtubule-based movement (GO:0060632)2.76403512
97tRNA methylation (GO:0030488)2.75425129
98glomerular visceral epithelial cell development (GO:0072015)2.74938916
99regulation of activation of Janus kinase activity (GO:0010533)2.74736314
100natural killer cell activation involved in immune response (GO:0002323)2.74558014
101detection of other organism (GO:0098543)2.74177956
102establishment of apical/basal cell polarity (GO:0035089)2.73196384
103NAD biosynthetic process (GO:0009435)2.70720452
104male meiosis I (GO:0007141)2.69493610
105sperm capacitation (GO:0048240)2.69083801
106negative regulation of histone methylation (GO:0031061)2.67928645
107cranial nerve morphogenesis (GO:0021602)2.67890504
108mitotic G1 DNA damage checkpoint (GO:0031571)2.66689895
109meiotic chromosome segregation (GO:0045132)2.64730812
110sequestering of actin monomers (GO:0042989)2.63093446
111DNA catabolic process, exonucleolytic (GO:0000738)2.62239631
112glomerular epithelial cell development (GO:0072310)2.62226184
113fertilization (GO:0009566)2.58911761
114regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.56048166
115intraciliary transport (GO:0042073)2.55936999
116spermatogenesis (GO:0007283)2.55432295
117male gamete generation (GO:0048232)2.55265042
118chromosome organization involved in meiosis (GO:0070192)2.54751591
119regulation of nuclear cell cycle DNA replication (GO:0033262)2.52629673
120detection of bacterium (GO:0016045)2.52521159
121DNA ligation (GO:0006266)2.52033853
122protein localization to cilium (GO:0061512)2.51600027
123negative regulation of DNA-dependent DNA replication (GO:2000104)2.50946451
124negative regulation of viral genome replication (GO:0045071)2.47210063
125dendritic cell chemotaxis (GO:0002407)2.44748310
126regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.44402638
127regulation of mitotic spindle checkpoint (GO:1903504)2.44402638
128replicative senescence (GO:0090399)2.44306873
129protein K6-linked ubiquitination (GO:0085020)2.42900549
130response to interferon-beta (GO:0035456)2.42325423
131gamete generation (GO:0007276)2.39345773
132DNA synthesis involved in DNA repair (GO:0000731)2.37372194
133kinetochore assembly (GO:0051382)2.35958826
134deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.35497400
135platelet dense granule organization (GO:0060155)2.34724873
136cytochrome complex assembly (GO:0017004)2.33803068
137reciprocal meiotic recombination (GO:0007131)2.32563758
138reciprocal DNA recombination (GO:0035825)2.32563758
139cilium assembly (GO:0042384)2.31831627
140synaptonemal complex organization (GO:0070193)2.31180670
141mesenchymal cell differentiation involved in renal system development (GO:2001012)2.29454760
142mesenchymal cell differentiation involved in kidney development (GO:0072161)2.29454760
143transcription elongation from RNA polymerase III promoter (GO:0006385)2.26855457
144termination of RNA polymerase III transcription (GO:0006386)2.26855457
145cilium organization (GO:0044782)2.26646746
146DNA-dependent DNA replication (GO:0006261)2.26616567
147regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.26125865
148synaptonemal complex assembly (GO:0007130)2.26007520
149DNA double-strand break processing (GO:0000729)2.25810110
150deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.25598167
151energy homeostasis (GO:0097009)2.25470331
152regulation of antigen processing and presentation (GO:0002577)2.25447377
153lipoxygenase pathway (GO:0019372)2.25058089
154regulation of RIG-I signaling pathway (GO:0039535)2.24198850
155nucleoside diphosphate catabolic process (GO:0009134)2.24019848
156microtubule polymerization or depolymerization (GO:0031109)2.23118868
157GTP biosynthetic process (GO:0006183)2.22472524
158protein K11-linked deubiquitination (GO:0035871)2.22293767
159female gonad development (GO:0008585)2.19188961
160regulation of double-strand break repair via homologous recombination (GO:0010569)2.18652759
161regulation of mast cell activation (GO:0033003)2.17638153
162neutrophil activation (GO:0042119)2.17306133
163DNA integration (GO:0015074)2.16850057
164interferon-gamma production (GO:0032609)2.16031487
165cellular response to gamma radiation (GO:0071480)2.16001437
166regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.15710299
167response to pheromone (GO:0019236)10.0545703

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.40474259
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.61080919
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.59124725
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.36030939
5FLI1_27457419_Chip-Seq_LIVER_Mouse3.16819186
6PCGF2_27294783_Chip-Seq_ESCs_Mouse3.13546975
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.94847891
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.69278982
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.50410212
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.46277815
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.42969608
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36310578
13SUZ12_27294783_Chip-Seq_NPCs_Mouse2.35668359
14IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.34342355
15CBP_20019798_ChIP-Seq_JUKART_Human2.34342355
16NFE2_27457419_Chip-Seq_LIVER_Mouse2.33569695
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.33515614
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.29703461
19PCGF2_27294783_Chip-Seq_NPCs_Mouse2.21590947
20ELF1_20517297_ChIP-Seq_JURKAT_Human2.21206091
21ERA_21632823_ChIP-Seq_H3396_Human2.18086508
22NANOG_20526341_ChIP-Seq_ESCs_Human2.17391935
23EBNA2_21746931_ChIP-Seq_IB4-LCL_Human2.10640669
24RBPJ_21746931_ChIP-Seq_IB4-LCL_Human2.05385519
25CTCF_27219007_Chip-Seq_Bcells_Human2.05049584
26TDRD3_21172665_ChIP-Seq_MCF-7_Human2.04897966
27RAC3_21632823_ChIP-Seq_H3396_Human2.04178393
28ELF1_17652178_ChIP-ChIP_JURKAT_Human2.02485415
29VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.95463497
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94452034
31EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.93158284
32GBX2_23144817_ChIP-Seq_PC3_Human1.89559068
33EZH2_27294783_Chip-Seq_NPCs_Mouse1.85754695
34WDR5_24793694_ChIP-Seq_LNCAP_Human1.85001158
35EZH2_22144423_ChIP-Seq_EOC_Human1.84741175
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.84059597
37DROSHA_22980978_ChIP-Seq_HELA_Human1.83156436
38YY1_22570637_ChIP-Seq_MALME-3M_Human1.81759393
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81558630
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.79600576
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78712839
42OCT4_20526341_ChIP-Seq_ESCs_Human1.77381899
43SUZ12_18555785_Chip-Seq_ESCs_Mouse1.75908523
44TP63_19390658_ChIP-ChIP_HaCaT_Human1.75142708
45STAT3_18555785_Chip-Seq_ESCs_Mouse1.74787371
46SMC4_20622854_ChIP-Seq_HELA_Human1.74258709
47P68_20966046_ChIP-Seq_HELA_Human1.73987058
48EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.72880743
49TAF2_19829295_ChIP-Seq_ESCs_Human1.71699308
50KAP1_22055183_ChIP-Seq_ESCs_Mouse1.71412773
51PHF8_20622854_ChIP-Seq_HELA_Human1.70292932
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.69784435
53TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.69541353
54P53_22387025_ChIP-Seq_ESCs_Mouse1.69492450
55E2F1_20622854_ChIP-Seq_HELA_Human1.69316080
56NMYC_18555785_Chip-Seq_ESCs_Mouse1.68891928
57BCL6_27268052_Chip-Seq_Bcells_Human1.68606630
58E2F1_18555785_Chip-Seq_ESCs_Mouse1.66902899
59EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.66630759
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.64827146
61ARNT_22903824_ChIP-Seq_MCF-7_Human1.64480432
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62813769
63MYC_19829295_ChIP-Seq_ESCs_Human1.62433099
64CTCF_20526341_ChIP-Seq_ESCs_Human1.62381670
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61455598
66VDR_22108803_ChIP-Seq_LS180_Human1.59994543
67OCT4_18555785_Chip-Seq_ESCs_Mouse1.58287402
68P300_18555785_Chip-Seq_ESCs_Mouse1.58211436
69RUNX1_27457419_Chip-Seq_LIVER_Mouse1.57688108
70* TP63_22573176_ChIP-Seq_HFKS_Human1.57511097
71CBX2_27304074_Chip-Seq_ESCs_Mouse1.57200680
72LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.56683702
73CMYC_18555785_Chip-Seq_ESCs_Mouse1.54837597
74BCOR_27268052_Chip-Seq_Bcells_Human1.52928622
75AUTS2_25519132_ChIP-Seq_293T-REX_Human1.52376081
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.52118926
77ZFX_18555785_Chip-Seq_ESCs_Mouse1.51379572
78TAL1_26923725_Chip-Seq_HPCs_Mouse1.51195444
79PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.50493090
80ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.49625974
81SOX2_22085726_ChIP-Seq_NPCs_Mouse1.49587754
82STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49357901
83KLF4_18555785_Chip-Seq_ESCs_Mouse1.49170602
84SOX2_18555785_Chip-Seq_ESCs_Mouse1.48794540
85P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.48791470
86PU1_27457419_Chip-Seq_LIVER_Mouse1.48245228
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.48223016
88P53_21459846_ChIP-Seq_SAOS-2_Human1.47915293
89SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46590354
90TAF15_26573619_Chip-Seq_HEK293_Human1.45280642
91SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.44546179
92SA1_27219007_Chip-Seq_Bcells_Human1.43962257
93RNF2_27304074_Chip-Seq_NSC_Mouse1.43676913
94ESRRB_18555785_Chip-Seq_ESCs_Mouse1.42805328
95KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.41808863
96CRX_20693478_ChIP-Seq_RETINA_Mouse1.41731638
97P300_27268052_Chip-Seq_Bcells_Human1.41663912
98BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41471067
99SCL_19346495_ChIP-Seq_HPC-7_Human1.39476376
100SMAD1_18555785_Chip-Seq_ESCs_Mouse1.39071749
101ERG_20517297_ChIP-Seq_VCAP_Human1.38842433
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36881698
103IRF1_19129219_ChIP-ChIP_H3396_Human1.36412645
104CTCF_18555785_Chip-Seq_ESCs_Mouse1.35283170
105SRF_21415370_ChIP-Seq_HL-1_Mouse1.35087751
106CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33676144
107ZNF274_21170338_ChIP-Seq_K562_Hela1.33416233
108ETV2_25802403_ChIP-Seq_MESCs_Mouse1.31865682
109SMAD3_21741376_ChIP-Seq_ESCs_Human1.30844009
110RBPJ_21746931_ChIP-Seq_IB4_Human1.30699401
111CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.30048341
112LXR_22292898_ChIP-Seq_THP-1_Human1.29591887
113* GATA3_21878914_ChIP-Seq_MCF-7_Human1.28924779
114* HOXB7_26014856_ChIP-Seq_BT474_Human1.28276540
115CBX2_22325352_ChIP-Seq_293T-Rex_Human1.28218159
116CEBPB_22108803_ChIP-Seq_LS180_Human1.27923908
117* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27352141
118JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.27348771
119HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.26539458
120STAT1_17558387_ChIP-Seq_HELA_Human1.26406222
121FUS_26573619_Chip-Seq_HEK293_Human1.26053708
122NANOG_19829295_ChIP-Seq_ESCs_Human1.25488165
123SOX2_19829295_ChIP-Seq_ESCs_Human1.25488165
124HNFA_21074721_ChIP-Seq_CACO-2_Human1.24891633
125OCT4_21477851_ChIP-Seq_ESCs_Mouse1.24819395
126PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23521550
127RUNX1_27514584_Chip-Seq_MCF-7_Human1.23300110
128CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22438979
129* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22194918
130ETV1_20927104_ChIP-Seq_GIST48_Human1.22051118
131AR_25329375_ChIP-Seq_VCAP_Human1.20117696
132RUNX1_26923725_Chip-Seq_HPCs_Mouse1.19750581
133LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18421101
134SOX2_21211035_ChIP-Seq_LN229_Human1.18240642
135MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16734333
136MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16674199
137E2F7_22180533_ChIP-Seq_HELA_Human1.15811493
138PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.15797112
139IRF8_27001747_Chip-Seq_BMDM_Mouse1.15480201
140GATA3_21867929_ChIP-Seq_CD8_Mouse1.13878363
141FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.13526598
142ER_23166858_ChIP-Seq_MCF-7_Human1.13188787
143SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.12444182
144SMAD3_21741376_ChIP-Seq_EPCs_Human1.11782766
145AR_21572438_ChIP-Seq_LNCaP_Human1.10680528
146POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10256120
147OCT4_19829295_ChIP-Seq_ESCs_Human1.10022633
148LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09784864
149STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09535158
150P300_19829295_ChIP-Seq_ESCs_Human1.08757591
151SOX11_22085726_ChIP-Seq_ESNs_Mouse1.08610618
152E2F1_17053090_ChIP-ChIP_MCF-7_Human1.08014721
153EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07682823
154NFYB_21822215_ChIP-Seq_K562_Human1.07253400
155FOXH1_21741376_ChIP-Seq_ESCs_Human1.07004566
156ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06948984
157EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06480933
158PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05798809
159PHF8_20622853_ChIP-Seq_HELA_Human1.05669969
160TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05655362
161CTCF_21964334_Chip-Seq_Bcells_Human1.05488130
162SMAD4_21741376_ChIP-Seq_HESCs_Human1.04791782
163NCOR_22424771_ChIP-Seq_293T_Human1.03783334
164PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03189512
165MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.03166235
166GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.02359325
167GATA6_21074721_ChIP-Seq_CACO-2_Human1.01698156
168RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01145422
169SUZ12_27294783_Chip-Seq_ESCs_Mouse1.00621713
170EWS_26573619_Chip-Seq_HEK293_Human0.99297999
171KDM2B_26808549_Chip-Seq_REH_Human0.98677828
172* STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.98223527
173RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.96664732
174GABP_17652178_ChIP-ChIP_JURKAT_Human0.95893682
175POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94321434
176SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94216604
177BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.93851718
178SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.92819774
179POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92815365
180TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92815365
181FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.92166348
182EST1_17652178_ChIP-ChIP_JURKAT_Human0.90418703
183ELK1_19687146_ChIP-ChIP_HELA_Human0.90266769
184GATA3_21867929_ChIP-Seq_TH1_Mouse0.89408290
185YY1_21170310_ChIP-Seq_MESCs_Mouse0.88714903
186KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.88500336

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.78118897
2MP0003878_abnormal_ear_physiology4.44087027
3MP0005377_hearing/vestibular/ear_phenot4.44087027
4MP0003646_muscle_fatigue4.02636380
5MP0006292_abnormal_olfactory_placode3.89537731
6MP0001188_hyperpigmentation2.96496784
7MP0003136_yellow_coat_color2.83851493
8MP0001348_abnormal_lacrimal_gland2.78474097
9MP0001835_abnormal_antigen_presentation2.75754736
10MP0008058_abnormal_DNA_repair2.72206682
11MP0000015_abnormal_ear_pigmentation2.54407867
12MP0000566_synostosis2.37303963
13MP0008877_abnormal_DNA_methylation2.32825111
14MP0002148_abnormal_hypersensitivity_rea2.21296814
15MP0001986_abnormal_taste_sensitivity2.21076449
16MP0009785_altered_susceptibility_to2.21040366
17MP0005671_abnormal_response_to2.20924741
18MP0002132_abnormal_respiratory_system2.08929166
19MP0005171_absent_coat_pigmentation2.05628111
20MP0005174_abnormal_tail_pigmentation2.03891094
21MP0002277_abnormal_respiratory_mucosa2.03205883
22MP0003698_abnormal_male_reproductive2.02807416
23MP0001929_abnormal_gametogenesis1.96398867
24MP0005423_abnormal_somatic_nervous1.91207761
25MP0005075_abnormal_melanosome_morpholog1.89594168
26MP0001968_abnormal_touch/_nociception1.86821955
27MP0008057_abnormal_DNA_replication1.82104307
28MP0005083_abnormal_biliary_tract1.81980466
29MP0005409_darkened_coat_color1.79731037
30MP0002127_abnormal_cardiovascular_syste1.76575396
31MP0002138_abnormal_hepatobiliary_system1.76049669
32MP0000372_irregular_coat_pigmentation1.71995886
33MP0002210_abnormal_sex_determination1.70791445
34MP0005451_abnormal_body_composition1.70579463
35MP0004036_abnormal_muscle_relaxation1.65712959
36MP0000751_myopathy1.64520019
37MP0000749_muscle_degeneration1.64231261
38MP0004381_abnormal_hair_follicle1.62958279
39MP0004145_abnormal_muscle_electrophysio1.62273683
40MP0009697_abnormal_copulation1.60327047
41MP0003724_increased_susceptibility_to1.59605894
42MP0003011_delayed_dark_adaptation1.59597159
43MP0010094_abnormal_chromosome_stability1.52907632
44MP0005379_endocrine/exocrine_gland_phen1.50722791
45MP0002102_abnormal_ear_morphology1.50107997
46MP0002095_abnormal_skin_pigmentation1.47792050
47MP0005025_abnormal_response_to1.46956674
48MP0004233_abnormal_muscle_weight1.46604976
49MP0002419_abnormal_innate_immunity1.46461951
50MP0002249_abnormal_larynx_morphology1.46159431
51MP0005000_abnormal_immune_tolerance1.46133049
52MP0008007_abnormal_cellular_replicative1.44311265
53MP0008260_abnormal_autophagy1.42966919
54MP0002160_abnormal_reproductive_system1.42500713
55MP0003786_premature_aging1.38632280
56MP0003941_abnormal_skin_development1.38429325
57MP0002234_abnormal_pharynx_morphology1.38405504
58MP0004084_abnormal_cardiac_muscle1.36829809
59MP0003693_abnormal_embryo_hatching1.35700741
60MP0002452_abnormal_antigen_presenting1.34946519
61MP0002723_abnormal_immune_serum1.33358707
62MP0005646_abnormal_pituitary_gland1.32962236
63MP0008995_early_reproductive_senescence1.32836482
64MP0001790_abnormal_immune_system1.30891260
65MP0005387_immune_system_phenotype1.30891260
66MP0003763_abnormal_thymus_physiology1.29326171
67MP0001485_abnormal_pinna_reflex1.28789948
68MP0002876_abnormal_thyroid_physiology1.28772492
69MP0001486_abnormal_startle_reflex1.26520537
70MP0001800_abnormal_humoral_immune1.24963891
71MP0001819_abnormal_immune_cell1.24784067
72MP0001984_abnormal_olfaction1.24705404
73MP0002420_abnormal_adaptive_immunity1.23794943
74MP0003111_abnormal_nucleus_morphology1.23470315
75MP0001145_abnormal_male_reproductive1.21920954
76MP0002736_abnormal_nociception_after1.21256261
77MP0004782_abnormal_surfactant_physiolog1.21018783
78MP0002638_abnormal_pupillary_reflex1.20689494
79MP0003436_decreased_susceptibility_to1.19969846
80MP0002396_abnormal_hematopoietic_system1.19358069
81MP0000678_abnormal_parathyroid_gland1.19154575
82MP0002822_catalepsy1.14378980
83MP0002735_abnormal_chemical_nociception1.13174783
84MP0000653_abnormal_sex_gland1.12048716
85MP0002009_preneoplasia1.11555322
86MP0002269_muscular_atrophy1.11141267
87MP0005389_reproductive_system_phenotype1.09938041
88MP0000490_abnormal_crypts_of1.07236262
89MP0005645_abnormal_hypothalamus_physiol1.06945014
90MP0002938_white_spotting1.06390752
91MP0003787_abnormal_imprinting1.05999576
92MP0009764_decreased_sensitivity_to1.02467974
93MP0001119_abnormal_female_reproductive1.01959822
94MP0001853_heart_inflammation1.01634345
95MP0002398_abnormal_bone_marrow0.99964679
96MP0002734_abnormal_mechanical_nocicepti0.99409876
97MP0006082_CNS_inflammation0.99171202
98MP0000681_abnormal_thyroid_gland0.98914572
99MP0002163_abnormal_gland_morphology0.96483918
100MP0004808_abnormal_hematopoietic_stem0.95715732
101MP0002161_abnormal_fertility/fecundity0.95653164
102MP0000716_abnormal_immune_system0.94480572
103MP0002106_abnormal_muscle_physiology0.93713539
104MP0004087_abnormal_muscle_fiber0.93050809
105MP0002405_respiratory_system_inflammati0.90823487
106MP0001186_pigmentation_phenotype0.90431310
107MP0005395_other_phenotype0.89709369
108MP0000534_abnormal_ureter_morphology0.89625329
109MP0000759_abnormal_skeletal_muscle0.89230264
110MP0005464_abnormal_platelet_physiology0.88136537
111MP0005397_hematopoietic_system_phenotyp0.86479003
112MP0001545_abnormal_hematopoietic_system0.86479003
113MP0005620_abnormal_muscle_contractility0.86158195
114MP0001919_abnormal_reproductive_system0.85540822
115MP0005310_abnormal_salivary_gland0.85292045
116MP0004147_increased_porphyrin_level0.84544088
117MP0009333_abnormal_splenocyte_physiolog0.84482340
118MP0010386_abnormal_urinary_bladder0.83685167
119MP0000685_abnormal_immune_system0.83614082
120MP0005084_abnormal_gallbladder_morpholo0.83384715
121MP0009053_abnormal_anal_canal0.83208523
122MP0005670_abnormal_white_adipose0.83028353
123MP0009384_cardiac_valve_regurgitation0.81830608
124MP0003718_maternal_effect0.81069072
125MP0008789_abnormal_olfactory_epithelium0.80902044
126MP0005369_muscle_phenotype0.80707454
127MP0001963_abnormal_hearing_physiology0.80622427
128MP0005551_abnormal_eye_electrophysiolog0.80452940
129MP0003077_abnormal_cell_cycle0.80085423
130MP0000049_abnormal_middle_ear0.79763150
131MP0000689_abnormal_spleen_morphology0.79437828
132MP0004510_myositis0.77890633
133MP0003137_abnormal_impulse_conducting0.77061141
134MP0002429_abnormal_blood_cell0.76389564
135MP0005375_adipose_tissue_phenotype0.76237288
136MP0005253_abnormal_eye_physiology0.75350409
137MP0002075_abnormal_coat/hair_pigmentati0.75117511
138MP0003119_abnormal_digestive_system0.74975535
139MP0002282_abnormal_trachea_morphology0.74912495
140MP0000371_diluted_coat_color0.73984017
141MP0004957_abnormal_blastocyst_morpholog0.73276240
142MP0002006_tumorigenesis0.73159732
143MP0002177_abnormal_outer_ear0.72451052
144MP0005666_abnormal_adipose_tissue0.72229574
145MP0000026_abnormal_inner_ear0.72145280
146MP0004742_abnormal_vestibular_system0.72046634
147MP0004085_abnormal_heartbeat0.72017864
148MP0000003_abnormal_adipose_tissue0.71080528
149MP0001765_abnormal_ion_homeostasis0.70782600
150MP0005167_abnormal_blood-brain_barrier0.70183751
151MP0002229_neurodegeneration0.68477768
152MP0008569_lethality_at_weaning0.68025263
153MP0000733_abnormal_muscle_development0.67906776
154MP0005266_abnormal_metabolism0.62239867
155MP0009115_abnormal_fat_cell0.61993062
156MP0005248_abnormal_Harderian_gland0.61007109
157MP0004484_altered_response_of0.60844657
158MP0000747_muscle_weakness0.59945396
159MP0000467_abnormal_esophagus_morphology0.59239473
160MP0001764_abnormal_homeostasis0.59097253
161MP0003879_abnormal_hair_cell0.58170311
162MP0004270_analgesia0.55626616
163MP0000470_abnormal_stomach_morphology0.54932835
164MP0002067_abnormal_sensory_capabilities0.53866548
165MP0002108_abnormal_muscle_morphology0.53353127
166MP0000516_abnormal_urinary_system0.53045878
167MP0005367_renal/urinary_system_phenotyp0.53045878
168MP0003936_abnormal_reproductive_system0.53036283
169MP0001529_abnormal_vocalization0.52135164
170MP0000955_abnormal_spinal_cord0.50855369
171MP0002332_abnormal_exercise_endurance0.50468720
172MP0006036_abnormal_mitochondrial_physio0.49573558
173MP0003699_abnormal_female_reproductive0.46690073
174MP0000750_abnormal_muscle_regeneration0.45867122
175MP0005535_abnormal_body_temperature0.45218253
176MP0004264_abnormal_extraembryonic_tissu0.44569419
177MP0002972_abnormal_cardiac_muscle0.43353122
178MP0005391_vision/eye_phenotype0.43139194

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)6.32535527
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.32535527
3Asymmetric septal hypertrophy (HP:0001670)5.25898230
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.13260174
5Abnormal respiratory epithelium morphology (HP:0012253)4.80982257
6Abnormal respiratory motile cilium morphology (HP:0005938)4.80982257
7Muscle fiber inclusion bodies (HP:0100299)4.67538213
8Nemaline bodies (HP:0003798)4.43389552
9Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.41281217
10Bony spicule pigmentary retinopathy (HP:0007737)4.27266941
11Hyperkalemia (HP:0002153)4.26782435
12Chromosomal breakage induced by crosslinking agents (HP:0003221)4.14530505
13Abnormal respiratory motile cilium physiology (HP:0012261)4.00188744
14Resting tremor (HP:0002322)3.87799924
15Abnormal ciliary motility (HP:0012262)3.85554595
16Chromsome breakage (HP:0040012)3.80150843
17Male infertility (HP:0003251)3.43008555
18Cone-rod dystrophy (HP:0000548)3.31555376
19Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.23490118
20Bell-shaped thorax (HP:0001591)3.21590310
21Aplasia/Hypoplasia of the earlobes (HP:0009906)3.20392266
22Potter facies (HP:0002009)3.17636645
23Facial shape deformation (HP:0011334)3.17636645
24Exercise-induced myalgia (HP:0003738)3.17055000
25Hypoalphalipoproteinemia (HP:0003233)3.15751679
26Type 2 muscle fiber atrophy (HP:0003554)3.12528737
27Optic neuritis (HP:0100653)3.12232334
28Retrobulbar optic neuritis (HP:0100654)3.12232334
29Abnormal rod and cone electroretinograms (HP:0008323)3.05822107
30Abnormality of macular pigmentation (HP:0008002)3.03202602
31Type 1 muscle fiber predominance (HP:0003803)2.99534274
32Exercise-induced muscle cramps (HP:0003710)2.94559692
33Fatigable weakness (HP:0003473)2.92883027
34Abnormality of the neuromuscular junction (HP:0003398)2.92883027
35True hermaphroditism (HP:0010459)2.89260376
36Rhinitis (HP:0012384)2.81240525
37Type I transferrin isoform profile (HP:0003642)2.80738989
38Enlarged epiphyses (HP:0010580)2.79247183
39Muscle hypertrophy of the lower extremities (HP:0008968)2.78780191
40Hypoplastic ischia (HP:0003175)2.76531876
41Ventricular tachycardia (HP:0004756)2.74218322
42Nephronophthisis (HP:0000090)2.67248367
43Amelogenesis imperfecta (HP:0000705)2.58976060
44Pancreatic fibrosis (HP:0100732)2.58910619
45Abnormality of the preputium (HP:0100587)2.57745632
46Unilateral renal agenesis (HP:0000122)2.57733619
47Clubbing of toes (HP:0100760)2.56727860
48Abnormal spermatogenesis (HP:0008669)2.56580322
49Abnormality of the renal collecting system (HP:0004742)2.56407296
50Double outlet right ventricle (HP:0001719)2.55335989
51Congenital malformation of the right heart (HP:0011723)2.55335989
52Renal dysplasia (HP:0000110)2.55162742
53Myoglobinuria (HP:0002913)2.52531635
54Abnormality of the nasal mucosa (HP:0000433)2.51417353
55Muscle fiber atrophy (HP:0100295)2.51333969
56Aplasia/Hypoplasia of the uvula (HP:0010293)2.49351464
57Recurrent abscess formation (HP:0002722)2.48054314
58Prostate neoplasm (HP:0100787)2.47090192
59Abnormality of the parathyroid morphology (HP:0011766)2.46366198
60Medial flaring of the eyebrow (HP:0010747)2.45256982
61Orchitis (HP:0100796)2.43737025
62Rhabdomyolysis (HP:0003201)2.42112801
63Meckel diverticulum (HP:0002245)2.41788903
64Abnormality of potassium homeostasis (HP:0011042)2.41154944
65Abnormality of the ischium (HP:0003174)2.40886502
66Reduced antithrombin III activity (HP:0001976)2.40398604
67Postural instability (HP:0002172)2.39233902
68Abnormality of the renal medulla (HP:0100957)2.35055052
69Myositis (HP:0100614)2.33867485
70Abnormality of the ileum (HP:0001549)2.33675920
71Duplicated collecting system (HP:0000081)2.31516518
72Menstrual irregularities (HP:0000858)2.29843922
73Pancreatic cysts (HP:0001737)2.28176571
74Decreased central vision (HP:0007663)2.26670382
75Abnormality of the aortic arch (HP:0012303)2.26488594
76Abnormality of chromosome stability (HP:0003220)2.26243982
77Distal lower limb muscle weakness (HP:0009053)2.26145349
78Abnormality of the left ventricular outflow tract (HP:0011103)2.24497868
79Subaortic stenosis (HP:0001682)2.24497868
80Patchy hypopigmentation of hair (HP:0011365)2.23300788
81Hypoplasia of the thymus (HP:0000778)2.22313366
82Calf muscle hypertrophy (HP:0008981)2.22261081
83Malignant hyperthermia (HP:0002047)2.22233565
84Bronchiectasis (HP:0002110)2.20694624
85Abnormal urine output (HP:0012590)2.20543903
86Recurrent sinusitis (HP:0011108)2.19888314
87Hyperuricemia (HP:0002149)2.18613272
88Increased purine levels (HP:0004368)2.18613272
893-Methylglutaconic aciduria (HP:0003535)2.17667062
90Chronic bronchitis (HP:0004469)2.15377157
91Insulin-resistant diabetes mellitus (HP:0000831)2.13970041
92Abnormality of the femoral head (HP:0003368)2.12667511
93Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.12545594
94Distal arthrogryposis (HP:0005684)2.11746762
95Ectopic kidney (HP:0000086)2.10818734
96Abnormality of the epiphysis of the femoral head (HP:0010574)2.10803103
97Postaxial foot polydactyly (HP:0001830)2.10594361
98Median cleft lip (HP:0000161)2.09639970
99Abnormality of midbrain morphology (HP:0002418)2.08873207
100Molar tooth sign on MRI (HP:0002419)2.08873207
101Tubulointerstitial nephritis (HP:0001970)2.08585103
102Optic nerve hypoplasia (HP:0000609)2.07361122
103Hyporeflexia of lower limbs (HP:0002600)2.04953694
104Easy fatigability (HP:0003388)2.04361641
105Truncal obesity (HP:0001956)2.04038444
106White forelock (HP:0002211)2.03668201
107Abnormality of DNA repair (HP:0003254)2.02199557
108Azoospermia (HP:0000027)2.01992939
109Hypoplasia of the fovea (HP:0007750)2.01699960
110Aplasia/Hypoplasia of the fovea (HP:0008060)2.01699960
111Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.99939916
112Absent epiphyses (HP:0010577)1.99939916
113Weak cry (HP:0001612)1.99820103
114Abnormality of dental color (HP:0011073)1.97939087
115Infertility (HP:0000789)1.96956476
116Nonprogressive disorder (HP:0003680)1.96928954
117Generalized aminoaciduria (HP:0002909)1.96421152
118Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95423622
119Abnormal protein N-linked glycosylation (HP:0012347)1.95423622
120Abnormal protein glycosylation (HP:0012346)1.95423622
121Abnormal glycosylation (HP:0012345)1.95423622
122Progressive sensorineural hearing impairment (HP:0000408)1.94827828
123Septo-optic dysplasia (HP:0100842)1.94736779
124Scotoma (HP:0000575)1.94654253
125Polydipsia (HP:0001959)1.94450503
126Abnormal drinking behavior (HP:0030082)1.94450503
127Hyponatremia (HP:0002902)1.92352467
128Fetal akinesia sequence (HP:0001989)1.89849088
129Abnormal ventriculo-arterial connection (HP:0011563)1.89408431
130Transposition of the great arteries (HP:0001669)1.89408431
131Abnormal connection of the cardiac segments (HP:0011545)1.89408431
132Abnormality of renal excretion (HP:0011036)1.88722883
133Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.88556919
134Abnormality of femoral epiphyses (HP:0006499)1.88556919
135Cerebellar dysplasia (HP:0007033)1.88055527
136Alveolar cell carcinoma (HP:0006519)1.87357528
137Congenital hepatic fibrosis (HP:0002612)1.87285554
138Recurrent bacterial skin infections (HP:0005406)1.87172525
139Attenuation of retinal blood vessels (HP:0007843)1.86995878
140Congenital sensorineural hearing impairment (HP:0008527)1.86392004
141Petechiae (HP:0000967)1.86038563
142Abnormality of the prostate (HP:0008775)1.85654375
143Supernumerary spleens (HP:0009799)1.85459427
144Renal cortical cysts (HP:0000803)1.85077173
145Hypoplasia of the pons (HP:0012110)1.85060100
146Preaxial hand polydactyly (HP:0001177)1.84916896
147Hypergonadotropic hypogonadism (HP:0000815)1.83709053
148Bone marrow hypocellularity (HP:0005528)1.83471866
149Increased IgM level (HP:0003496)1.83183017
150Mediastinal lymphadenopathy (HP:0100721)1.82551263
151Muscle fiber splitting (HP:0003555)1.82284099
152Abnormality of the pons (HP:0007361)1.81803607
153Chronic hepatic failure (HP:0100626)1.80323459
154Small intestinal stenosis (HP:0012848)1.80042001
155Duodenal stenosis (HP:0100867)1.80042001
156Bronchitis (HP:0012387)1.79229572
157Nephrogenic diabetes insipidus (HP:0009806)1.78388242
158Nasal polyposis (HP:0100582)1.77511429
159Abnormality of the renal cortex (HP:0011035)1.77345910
160Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77042762
161Recurrent pneumonia (HP:0006532)1.75672907
162Chronic obstructive pulmonary disease (HP:0006510)1.75606666
163Obstructive lung disease (HP:0006536)1.75606666
164Keratoconjunctivitis sicca (HP:0001097)1.72539852
165Aplastic anemia (HP:0001915)1.71918445
166Myelodysplasia (HP:0002863)1.70493408
167Aplasia/Hypoplasia of the tibia (HP:0005772)1.70262709
168Abnormality of incisor morphology (HP:0011063)1.68718754
169Male pseudohermaphroditism (HP:0000037)1.68586119
170Meningitis (HP:0001287)1.66742738
171Absent rod-and cone-mediated responses on ERG (HP:0007688)1.65787090
172Eczematoid dermatitis (HP:0000976)1.65291525
173Impulsivity (HP:0100710)1.64780750
174Encephalitis (HP:0002383)1.64697990
175Prolonged bleeding time (HP:0003010)1.64418510
176Severe visual impairment (HP:0001141)1.63739455
177Glomerulopathy (HP:0100820)1.63274074
178Dyschromatopsia (HP:0007641)1.63067741

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN3.67600965
2IRAK33.49543808
3DDR23.28605868
4IRAK43.08939485
5ZAK3.07553332
6STK162.89997044
7TXK2.82797069
8PLK42.71626789
9PNCK2.69081813
10MUSK2.68767382
11PLK22.59527231
12CASK2.40114188
13MAP3K142.34322635
14MAP4K22.25699802
15PRKD32.03447842
16MKNK22.00597922
17YES11.89230633
18SRPK11.88282806
19EIF2AK21.78998466
20IRAK11.77330881
21SIK31.74829776
22BMPR21.72751048
23CAMK1G1.72705978
24MKNK11.72423528
25PHKG11.68005868
26PHKG21.68005868
27PDPK11.67787997
28TNIK1.66372518
29TEC1.62508953
30PINK11.55335920
31NEK61.54891078
32PDK11.54608056
33IRAK21.52379104
34DYRK1B1.44585533
35ADRBK21.44448943
36IKBKB1.44103618
37BMPR1B1.42938463
38VRK11.37542694
39TTN1.36088672
40MST1R1.35176342
41BLK1.33320019
42IKBKE1.30968596
43CDK31.28428340
44PDK21.27444347
45PDK41.26470141
46PDK31.26470141
47AKT31.24496492
48GRK11.24214204
49MAP3K91.14747976
50MAP3K111.14689985
51WNK11.13391154
52MAP2K71.12279798
53TESK11.09201227
54CLK11.08914248
55TNK21.07779544
56EIF2AK31.07409997
57NLK1.02997962
58PTK2B1.01372762
59PBK0.98233952
60TIE10.93734267
61ATR0.93048047
62BTK0.91862508
63PRPF4B0.91518269
64CHUK0.90764381
65RIPK40.90651410
66GRK70.90581394
67STK38L0.90549239
68KDR0.88048620
69CCNB10.87498113
70EIF2AK10.85503832
71PRKG20.85053743
72VRK20.84395215
73PIM10.83265348
74JAK30.82937517
75BRD40.82653543
76INSRR0.81751046
77MAP3K120.81661467
78SGK20.80633559
79CDK80.80387302
80TAF10.80249824
81NME20.78850567
82NME10.78229913
83PIM20.77653147
84MAP2K20.76209208
85CDK120.76027932
86LATS10.75996442
87ERBB30.75408725
88BRAF0.74707329
89BUB10.74281473
90CAMK40.71174875
91RPS6KA20.69322749
92LYN0.68796513
93PRKG10.68771690
94MAPK130.67379344
95CAMK10.67279264
96KIT0.66337735
97MAP2K60.65718631
98NUAK10.65242331
99RPS6KA10.64197460
100MAP4K10.63837746
101PRKAA20.63264375
102CHEK20.63032969
103DYRK30.58852439
104RPS6KL10.58209528
105RPS6KC10.58209528
106DAPK20.58170814
107TTK0.57552796
108LATS20.57056853
109PLK10.56428830
110TYRO30.56057436
111SYK0.55447640
112UHMK10.55313082
113TAOK20.55136211
114RPS6KA50.54239900
115RPS6KA60.53802703
116STK40.51916753
117PLK30.50515515
118MARK30.50156218
119BRSK20.49742013
120ZAP700.47898584
121TBK10.47437870
122MAPKAPK50.45869991
123MST40.45497770
124MAPK70.45266322
125DYRK20.45081026
126CDK20.44749960
127PIK3CA0.44011611
128MAPK150.43857529
129GSK3B0.43371274
130TRIM280.42024784
131CSNK2A10.41600750
132CDK10.41577143
133PKN10.41008909
134PIK3CG0.40958096
135ATM0.40560574
136CHEK10.39807683
137TLK10.39650249
138CDK70.39617421
139MAP3K80.37221523
140RPS6KB10.36983729
141RPS6KB20.35664432
142LCK0.34589900
143CDK190.34363150
144PRKCD0.34195713
145TRPM70.33771172
146MTOR0.32827001
147ROCK10.32143286
148MAP3K70.32065558
149PRKCG0.31537314
150OXSR10.31366504
151AURKB0.28596612
152TESK20.28454605
153MAP2K10.26807188
154PRKCZ0.26321632
155STK390.26297968
156TRIB30.26091373
157MAPK80.25982581
158MAPK10.25955700
159CDC70.25314656
160STK240.24700198
161STK380.24695643
162PKN20.24443390
163CAMK2G0.23302092
164MAPK140.22584914
165KSR20.22275087
166CAMK1D0.20872622
167CDK40.20730473
168SGK10.20692811
169CAMK2A0.20206736
170AURKA0.19798075
171MAPK100.14972500
172PRKACB0.13810087
173PRKAA10.13195708
174CAMK2D0.13042188

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.78149058
2Fatty acid biosynthesis_Homo sapiens_hsa000614.98141386
3Olfactory transduction_Homo sapiens_hsa047403.67472272
4Fanconi anemia pathway_Homo sapiens_hsa034603.01060833
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.81722518
6Homologous recombination_Homo sapiens_hsa034402.62430214
7Cardiac muscle contraction_Homo sapiens_hsa042602.57912496
8Basal transcription factors_Homo sapiens_hsa030222.43945781
9Butanoate metabolism_Homo sapiens_hsa006502.39937110
10DNA replication_Homo sapiens_hsa030302.26630822
11RNA polymerase_Homo sapiens_hsa030202.25692996
12Graft-versus-host disease_Homo sapiens_hsa053322.22094721
13Allograft rejection_Homo sapiens_hsa053302.18849184
14Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.08528953
15Arginine and proline metabolism_Homo sapiens_hsa003301.92732914
16Proteasome_Homo sapiens_hsa030501.90097008
17Nitrogen metabolism_Homo sapiens_hsa009101.89594891
18Non-homologous end-joining_Homo sapiens_hsa034501.87797577
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.86340853
20Glycerophospholipid metabolism_Homo sapiens_hsa005641.85912486
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.85310097
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.85147545
23Fatty acid degradation_Homo sapiens_hsa000711.85101544
24Pyrimidine metabolism_Homo sapiens_hsa002401.84767153
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.83915002
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.82552608
27Autoimmune thyroid disease_Homo sapiens_hsa053201.74962729
28Base excision repair_Homo sapiens_hsa034101.73179414
29Mismatch repair_Homo sapiens_hsa034301.72375536
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.70637819
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.70233029
32Phenylalanine metabolism_Homo sapiens_hsa003601.68946444
33Measles_Homo sapiens_hsa051621.63466498
34Dorso-ventral axis formation_Homo sapiens_hsa043201.63012456
35Primary immunodeficiency_Homo sapiens_hsa053401.60726662
36Arachidonic acid metabolism_Homo sapiens_hsa005901.60170919
37Purine metabolism_Homo sapiens_hsa002301.57049800
38RNA degradation_Homo sapiens_hsa030181.51899550
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.51509477
40Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.49483737
41Arginine biosynthesis_Homo sapiens_hsa002201.49206540
42Nucleotide excision repair_Homo sapiens_hsa034201.43833317
43Asthma_Homo sapiens_hsa053101.43630034
44NOD-like receptor signaling pathway_Homo sapiens_hsa046211.37940640
45Fatty acid metabolism_Homo sapiens_hsa012121.37170244
46Herpes simplex infection_Homo sapiens_hsa051681.36946877
47Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.36447318
48Hematopoietic cell lineage_Homo sapiens_hsa046401.35080041
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.33837047
50Rheumatoid arthritis_Homo sapiens_hsa053231.33603558
51Viral myocarditis_Homo sapiens_hsa054161.33223209
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.31775030
53Protein export_Homo sapiens_hsa030601.30744098
54Spliceosome_Homo sapiens_hsa030401.28474192
55Calcium signaling pathway_Homo sapiens_hsa040201.28123451
56Other glycan degradation_Homo sapiens_hsa005111.22369208
57Leishmaniasis_Homo sapiens_hsa051401.21297316
58Legionellosis_Homo sapiens_hsa051341.21267281
59Sphingolipid metabolism_Homo sapiens_hsa006001.18695562
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.16171543
61Toll-like receptor signaling pathway_Homo sapiens_hsa046201.16098520
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14434464
63Fat digestion and absorption_Homo sapiens_hsa049751.14049138
64Biosynthesis of amino acids_Homo sapiens_hsa012301.10887713
65Linoleic acid metabolism_Homo sapiens_hsa005911.10871488
66ABC transporters_Homo sapiens_hsa020101.06224243
67Type I diabetes mellitus_Homo sapiens_hsa049401.05620008
68Phototransduction_Homo sapiens_hsa047441.05488558
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04912555
70Sulfur relay system_Homo sapiens_hsa041221.03712390
71Selenocompound metabolism_Homo sapiens_hsa004501.03663139
72Carbon metabolism_Homo sapiens_hsa012001.02118057
73beta-Alanine metabolism_Homo sapiens_hsa004101.02044847
74Influenza A_Homo sapiens_hsa051641.01211692
75Type II diabetes mellitus_Homo sapiens_hsa049300.99897325
76Propanoate metabolism_Homo sapiens_hsa006400.98154540
77Ribosome_Homo sapiens_hsa030100.97933505
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97301173
79Malaria_Homo sapiens_hsa051440.95804363
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95422264
81Cell cycle_Homo sapiens_hsa041100.94622071
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.90815858
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90339779
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.90048051
85Tight junction_Homo sapiens_hsa045300.89951288
86PPAR signaling pathway_Homo sapiens_hsa033200.88247571
87Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.87334825
88Ether lipid metabolism_Homo sapiens_hsa005650.86970885
89Oocyte meiosis_Homo sapiens_hsa041140.86844599
90RNA transport_Homo sapiens_hsa030130.85578122
91Inositol phosphate metabolism_Homo sapiens_hsa005620.83000310
92Dilated cardiomyopathy_Homo sapiens_hsa054140.82121305
93Antigen processing and presentation_Homo sapiens_hsa046120.81662241
94p53 signaling pathway_Homo sapiens_hsa041150.81176687
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79868140
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77416210
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76889357
98Epstein-Barr virus infection_Homo sapiens_hsa051690.76670398
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76623954
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75784647
101Glucagon signaling pathway_Homo sapiens_hsa049220.74958254
102TNF signaling pathway_Homo sapiens_hsa046680.71669481
103Synaptic vesicle cycle_Homo sapiens_hsa047210.71352799
104Tyrosine metabolism_Homo sapiens_hsa003500.70896116
105Histidine metabolism_Homo sapiens_hsa003400.70001847
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69913065
107Glycerolipid metabolism_Homo sapiens_hsa005610.68711633
108Huntingtons disease_Homo sapiens_hsa050160.68548173
109Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67757147
110Retinol metabolism_Homo sapiens_hsa008300.67620054
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67578003
112Vitamin B6 metabolism_Homo sapiens_hsa007500.66459945
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.65723246
114Pertussis_Homo sapiens_hsa051330.65652207
115Salivary secretion_Homo sapiens_hsa049700.63816761
116Insulin signaling pathway_Homo sapiens_hsa049100.63618523
117Morphine addiction_Homo sapiens_hsa050320.63068603
118African trypanosomiasis_Homo sapiens_hsa051430.61653665
119Taste transduction_Homo sapiens_hsa047420.60284001
120mRNA surveillance pathway_Homo sapiens_hsa030150.59390894
121Protein digestion and absorption_Homo sapiens_hsa049740.57244076
122Pyruvate metabolism_Homo sapiens_hsa006200.56842901
123Regulation of autophagy_Homo sapiens_hsa041400.56697634
124Vitamin digestion and absorption_Homo sapiens_hsa049770.56416458
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54907620
126Insulin resistance_Homo sapiens_hsa049310.54273236
127One carbon pool by folate_Homo sapiens_hsa006700.53493290
128Tuberculosis_Homo sapiens_hsa051520.53444139
129Osteoclast differentiation_Homo sapiens_hsa043800.52231533
130Salmonella infection_Homo sapiens_hsa051320.52028205
131Tryptophan metabolism_Homo sapiens_hsa003800.51640277
132Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48800861
133Circadian entrainment_Homo sapiens_hsa047130.47959123
1342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47863525
135Gastric acid secretion_Homo sapiens_hsa049710.46544223
136Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45767886
137cAMP signaling pathway_Homo sapiens_hsa040240.45486209
138Hedgehog signaling pathway_Homo sapiens_hsa043400.45120584
139Metabolic pathways_Homo sapiens_hsa011000.43585850
140Phagosome_Homo sapiens_hsa041450.43429531
141Endocytosis_Homo sapiens_hsa041440.42696049
142Nicotine addiction_Homo sapiens_hsa050330.42017242
143Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41590936
144Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41565212
145Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40664797
146Apoptosis_Homo sapiens_hsa042100.40102222
147Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40038605
148Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39828911
149Toxoplasmosis_Homo sapiens_hsa051450.38838288
150Oxidative phosphorylation_Homo sapiens_hsa001900.38141490
151Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37787505
152Renin-angiotensin system_Homo sapiens_hsa046140.37713900
153Maturity onset diabetes of the young_Homo sapiens_hsa049500.36800195
154Chemokine signaling pathway_Homo sapiens_hsa040620.36631500
155N-Glycan biosynthesis_Homo sapiens_hsa005100.36585470
156Insulin secretion_Homo sapiens_hsa049110.36326349
157Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36178577
158Lysine degradation_Homo sapiens_hsa003100.36030350
159cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35982372
160Shigellosis_Homo sapiens_hsa051310.35199009
161Collecting duct acid secretion_Homo sapiens_hsa049660.34514266
162Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34191241
163T cell receptor signaling pathway_Homo sapiens_hsa046600.34048128
164Mineral absorption_Homo sapiens_hsa049780.33843250
165Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33103031
166HTLV-I infection_Homo sapiens_hsa051660.32837985
167Steroid hormone biosynthesis_Homo sapiens_hsa001400.32772128
168Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32646012
169Systemic lupus erythematosus_Homo sapiens_hsa053220.31439873
170Hepatitis B_Homo sapiens_hsa051610.30901008
171Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.29824632
172B cell receptor signaling pathway_Homo sapiens_hsa046620.29260176
173Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28824048

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »