CCDC66

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)4.51874560
2kinetochore organization (GO:0051383)4.02349200
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.95021170
4snRNA processing (GO:0016180)3.92607678
5epithelial cilium movement (GO:0003351)3.87296606
6kinetochore assembly (GO:0051382)3.78692878
7replicative senescence (GO:0090399)3.77447500
8daunorubicin metabolic process (GO:0044597)3.72507831
9polyketide metabolic process (GO:0030638)3.72507831
10doxorubicin metabolic process (GO:0044598)3.72507831
11regulation of DNA endoreduplication (GO:0032875)3.72041265
12neural tube formation (GO:0001841)3.68435698
13snRNA metabolic process (GO:0016073)3.59558085
14cilium movement (GO:0003341)3.57476428
15negative regulation of translation, ncRNA-mediated (GO:0040033)3.54501889
16regulation of translation, ncRNA-mediated (GO:0045974)3.54501889
17negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.54501889
18establishment of protein localization to Golgi (GO:0072600)3.52091084
19intraciliary transport (GO:0042073)3.50739272
20regulation of pigment cell differentiation (GO:0050932)3.49620283
21protein polyglutamylation (GO:0018095)3.48441522
22detection of light stimulus involved in sensory perception (GO:0050962)3.44344608
23detection of light stimulus involved in visual perception (GO:0050908)3.44344608
24sperm motility (GO:0030317)3.42416394
25DNA ligation (GO:0006266)3.41444713
26axoneme assembly (GO:0035082)3.40558692
27* retinal rod cell development (GO:0046548)3.37690971
28regulation of cilium movement (GO:0003352)3.35755757
29attachment of spindle microtubules to kinetochore (GO:0008608)3.29180161
30protein targeting to Golgi (GO:0000042)3.25482918
31mitotic chromosome condensation (GO:0007076)3.16880539
32response to pheromone (GO:0019236)3.15492190
33cilium organization (GO:0044782)3.12483144
34establishment of chromosome localization (GO:0051303)3.08888010
35behavioral response to nicotine (GO:0035095)3.08518353
36axonemal dynein complex assembly (GO:0070286)3.08349571
37CENP-A containing nucleosome assembly (GO:0034080)3.08238890
38microtubule depolymerization (GO:0007019)3.08166667
39motile cilium assembly (GO:0044458)3.07981443
40negative regulation of DNA-dependent DNA replication (GO:2000104)3.07958566
41regulation of mitotic spindle checkpoint (GO:1903504)3.06438851
42regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.06438851
43piRNA metabolic process (GO:0034587)3.06244016
44cilium assembly (GO:0042384)3.04438166
45presynaptic membrane assembly (GO:0097105)3.04360535
46intra-S DNA damage checkpoint (GO:0031573)3.04141594
47metaphase plate congression (GO:0051310)3.01689754
48recombinational repair (GO:0000725)3.01330810
49detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.01110085
50sister chromatid cohesion (GO:0007062)3.00143071
51double-strand break repair via homologous recombination (GO:0000724)2.99615582
52histone exchange (GO:0043486)2.95872252
53photoreceptor cell maintenance (GO:0045494)2.92512626
54retrograde transport, vesicle recycling within Golgi (GO:0000301)2.91571975
55microtubule polymerization or depolymerization (GO:0031109)2.90751877
56rRNA methylation (GO:0031167)2.89978456
57nuclear pore complex assembly (GO:0051292)2.89437703
58RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.87168631
59replication fork processing (GO:0031297)2.85966196
60protein prenylation (GO:0018342)2.85678934
61prenylation (GO:0097354)2.85678934
62tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.85447199
63RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.85447199
64urinary tract smooth muscle contraction (GO:0014848)2.85406844
65DNA deamination (GO:0045006)2.84918997
66cilium morphogenesis (GO:0060271)2.84624429
67DNA synthesis involved in DNA repair (GO:0000731)2.84361960
68centriole replication (GO:0007099)2.83886183
69chromatin remodeling at centromere (GO:0031055)2.83409522
70acrosome reaction (GO:0007340)2.81394058
71reciprocal meiotic recombination (GO:0007131)2.80385159
72reciprocal DNA recombination (GO:0035825)2.80385159
73synapsis (GO:0007129)2.79950307
74pyrimidine dimer repair (GO:0006290)2.79701503
75centriole assembly (GO:0098534)2.79362700
76DNA methylation involved in gamete generation (GO:0043046)2.79213260
77protein K11-linked deubiquitination (GO:0035871)2.79054477
78negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.78915398
79regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.76741235
80pseudouridine synthesis (GO:0001522)2.76722329
81nuclear pore organization (GO:0006999)2.76356933
82DNA replication initiation (GO:0006270)2.76281044
83protein localization to cilium (GO:0061512)2.76007944
84cullin deneddylation (GO:0010388)2.75692830
85mitotic metaphase plate congression (GO:0007080)2.75245934
86poly(A)+ mRNA export from nucleus (GO:0016973)2.74516769
87regulation of centriole replication (GO:0046599)2.74135113
88nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.74082750
89resolution of meiotic recombination intermediates (GO:0000712)2.74024856
90protein-cofactor linkage (GO:0018065)2.73740861
91rRNA modification (GO:0000154)2.72185540
92indolalkylamine metabolic process (GO:0006586)2.71495769
93positive regulation of mitotic sister chromatid separation (GO:1901970)2.71368673
94positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.71368673
95positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.71368673
96pyrimidine nucleobase catabolic process (GO:0006208)2.70338919
97histone H3-K4 trimethylation (GO:0080182)2.70042228
98spindle checkpoint (GO:0031577)2.69490795
99limb bud formation (GO:0060174)2.69224103
100protein complex biogenesis (GO:0070271)2.68827159
101DNA replication-independent nucleosome assembly (GO:0006336)2.68618995
102DNA replication-independent nucleosome organization (GO:0034724)2.68618995
103single strand break repair (GO:0000012)2.68539327
104respiratory chain complex IV assembly (GO:0008535)2.68097611
105exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.66546664
106protein localization to Golgi apparatus (GO:0034067)2.66291852
107regulation of meiosis I (GO:0060631)2.66259083
108peptidyl-lysine trimethylation (GO:0018023)2.65872496
109regulation of mitotic sister chromatid separation (GO:0010965)2.65707327
110regulation of mitotic sister chromatid segregation (GO:0033047)2.65707327
111regulation of sister chromatid segregation (GO:0033045)2.65707327
112spindle assembly checkpoint (GO:0071173)2.65669257
113histone mRNA metabolic process (GO:0008334)2.65498790
114regulation of telomere maintenance (GO:0032204)2.64888011
115retinal cone cell development (GO:0046549)2.63529003
116negative regulation of mitotic sister chromatid separation (GO:2000816)2.63487756
117negative regulation of mitotic sister chromatid segregation (GO:0033048)2.63487756
118negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.63487756
119negative regulation of sister chromatid segregation (GO:0033046)2.63487756
120mRNA export from nucleus (GO:0006406)2.63135283
121GMP metabolic process (GO:0046037)2.62827512
122regulation of centrosome duplication (GO:0010824)2.62825060
123pericardium development (GO:0060039)2.62639118
124positive regulation of mRNA processing (GO:0050685)2.62269641
125DNA double-strand break processing (GO:0000729)2.61516971
126fucose catabolic process (GO:0019317)2.60433469
127L-fucose metabolic process (GO:0042354)2.60433469
128L-fucose catabolic process (GO:0042355)2.60433469
129regulation of mitotic metaphase/anaphase transition (GO:0030071)2.59824217
130tryptophan catabolic process (GO:0006569)2.59370026
131indole-containing compound catabolic process (GO:0042436)2.59370026
132indolalkylamine catabolic process (GO:0046218)2.59370026
133mitochondrial respiratory chain complex assembly (GO:0033108)2.59300701
134meiotic chromosome segregation (GO:0045132)2.58887864
135histone H2A acetylation (GO:0043968)2.57607300
136negative regulation of chromosome segregation (GO:0051985)2.57445828
137maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.57385788
138protein sumoylation (GO:0016925)2.57291224
139mitotic spindle assembly checkpoint (GO:0007094)2.57130110
140regulation of centrosome cycle (GO:0046605)2.55557187
141maturation of 5.8S rRNA (GO:0000460)2.55383934
142DNA topological change (GO:0006265)2.55254519
143negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.54668387
144nonmotile primary cilium assembly (GO:0035058)2.54008453
145mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.53562845
146mitochondrial respiratory chain complex I assembly (GO:0032981)2.53562845
147NADH dehydrogenase complex assembly (GO:0010257)2.53562845
148DNA replication checkpoint (GO:0000076)2.53286670
149regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.53092512
150nucleotide-excision repair, DNA gap filling (GO:0006297)2.52832839
151tachykinin receptor signaling pathway (GO:0007217)2.52607223
152presynaptic membrane organization (GO:0097090)2.50949558
153histamine secretion (GO:0001821)2.50430174
154male meiosis I (GO:0007141)2.50188546
155monoubiquitinated protein deubiquitination (GO:0035520)2.49115808
156protein deneddylation (GO:0000338)2.48908696
157microtubule anchoring (GO:0034453)2.48690504
158protein refolding (GO:0042026)2.48516462
159rRNA catabolic process (GO:0016075)2.48250461
160mitotic spindle checkpoint (GO:0071174)2.48136543
161regulation of hexokinase activity (GO:1903299)2.48092374
162regulation of glucokinase activity (GO:0033131)2.48092374
163kynurenine metabolic process (GO:0070189)2.46677076
164positive regulation of cell cycle checkpoint (GO:1901978)2.46370835
165regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.45279045
166positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.45279045
167multicellular organism reproduction (GO:0032504)2.44945892
168regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.44530222
169RNA export from nucleus (GO:0006405)2.43512246
170somite development (GO:0061053)2.43372507
171regulation of nuclear cell cycle DNA replication (GO:0033262)2.43210660
172protein localization to kinetochore (GO:0034501)2.42126225
173sister chromatid segregation (GO:0000819)2.41365180
174epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.39777274
175mitotic sister chromatid segregation (GO:0000070)2.37070862
176cilium or flagellum-dependent cell motility (GO:0001539)2.36210396
177myoblast migration (GO:0051451)2.35896437
178ATP-dependent chromatin remodeling (GO:0043044)2.35588767

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.19252083
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.17338557
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.07426134
4ZNF274_21170338_ChIP-Seq_K562_Hela3.06343124
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.05037109
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.73572663
7FUS_26573619_Chip-Seq_HEK293_Human2.73040620
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.51313541
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.49807324
10YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.44892694
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.44693957
12GBX2_23144817_ChIP-Seq_PC3_Human2.39323027
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.37784067
14* SALL1_21062744_ChIP-ChIP_HESCs_Human2.29926148
15* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.29784190
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.28974994
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.27722578
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.26241593
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.23476147
20EZH2_22144423_ChIP-Seq_EOC_Human2.09598325
21DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.02356041
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.02280004
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.92673693
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.90588053
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89102726
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.84941904
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80810226
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77897269
29EWS_26573619_Chip-Seq_HEK293_Human1.76855761
30TAF15_26573619_Chip-Seq_HEK293_Human1.72504862
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67214349
32ELK1_19687146_ChIP-ChIP_HELA_Human1.65784118
33CBP_20019798_ChIP-Seq_JUKART_Human1.63807543
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.63807543
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63175590
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61844458
37CIITA_25753668_ChIP-Seq_RAJI_Human1.61214295
38* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58981758
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.57067120
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.54946086
41EST1_17652178_ChIP-ChIP_JURKAT_Human1.52511930
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50648032
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.46867805
44VDR_22108803_ChIP-Seq_LS180_Human1.45941634
45IGF1R_20145208_ChIP-Seq_DFB_Human1.45770574
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.45440884
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.43609296
48GABP_17652178_ChIP-ChIP_JURKAT_Human1.42947089
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.42729729
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41626789
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39008099
52AR_25329375_ChIP-Seq_VCAP_Human1.38894444
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38872880
54P300_19829295_ChIP-Seq_ESCs_Human1.37932347
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.36785737
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36440185
57SOX9_26525672_Chip-Seq_HEART_Mouse1.36013132
58FOXP3_21729870_ChIP-Seq_TREG_Human1.35580364
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35504961
60SMAD4_21799915_ChIP-Seq_A2780_Human1.33883327
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31096078
62IRF1_19129219_ChIP-ChIP_H3396_Human1.31083827
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30011103
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29519931
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28079309
66MYC_18940864_ChIP-ChIP_HL60_Human1.25710396
67TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25419794
68TP53_22573176_ChIP-Seq_HFKS_Human1.24502631
69PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23741344
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23640643
71* RUNX2_22187159_ChIP-Seq_PCA_Human1.23196226
72NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22892972
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22579753
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.22522623
75TCF4_22108803_ChIP-Seq_LS180_Human1.22345102
76CREB1_15753290_ChIP-ChIP_HEK293T_Human1.22243830
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22035516
78MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20498704
79FLI1_21867929_ChIP-Seq_TH2_Mouse1.20206042
80CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20204625
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19679076
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19598847
83* VDR_23849224_ChIP-Seq_CD4+_Human1.18270677
84SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17361104
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.17057272
86SOX2_19829295_ChIP-Seq_ESCs_Human1.15213356
87NANOG_19829295_ChIP-Seq_ESCs_Human1.15213356
88JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.13896653
89CBX2_27304074_Chip-Seq_ESCs_Mouse1.13559798
90AR_21572438_ChIP-Seq_LNCaP_Human1.13050876
91MYC_18555785_ChIP-Seq_MESCs_Mouse1.12088440
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11738255
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11613422
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11613422
95SRF_21415370_ChIP-Seq_HL-1_Mouse1.11039147
96E2F1_18555785_Chip-Seq_ESCs_Mouse1.10809969
97NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10702690
98NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10593938
99FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09804921
100PIAS1_25552417_ChIP-Seq_VCAP_Human1.09177606
101CRX_20693478_ChIP-Seq_RETINA_Mouse1.09023965
102NFE2_27457419_Chip-Seq_LIVER_Mouse1.08914742
103STAT3_23295773_ChIP-Seq_U87_Human1.08582008
104BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06426419
105FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06387609
106FOXA1_25329375_ChIP-Seq_VCAP_Human1.06387609
107RNF2_27304074_Chip-Seq_NSC_Mouse1.06273636
108SCL_19346495_ChIP-Seq_HPC-7_Human1.06214836
109TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06070795
110* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06025147
111P53_22387025_ChIP-Seq_ESCs_Mouse1.05037328
112VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04558737
113P300_18555785_Chip-Seq_ESCs_Mouse1.04430069
114EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04277899
115AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04150768
116RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04056895
117TCF4_23295773_ChIP-Seq_U87_Human1.03933241
118PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02499247
119MYCN_18555785_ChIP-Seq_MESCs_Mouse1.02489651
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02348607
121ETV1_20927104_ChIP-Seq_GIST48_Human1.01728381
122SMAD4_21741376_ChIP-Seq_EPCs_Human1.00923382
123SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.00425121
124MYC_19030024_ChIP-ChIP_MESCs_Mouse0.99947371
125SMAD_19615063_ChIP-ChIP_OVARY_Human0.99112067
126CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98663111
127SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98574289
128SMAD3_21741376_ChIP-Seq_EPCs_Human0.96979299
129RBPJ_22232070_ChIP-Seq_NCS_Mouse0.96692572
130CMYC_18555785_Chip-Seq_ESCs_Mouse0.96408018
131SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.93810143
132STAT3_18555785_Chip-Seq_ESCs_Mouse0.93760515
133BCAT_22108803_ChIP-Seq_LS180_Human0.92176743
134CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91098053
135CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.90890254
136TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90717591
137ER_23166858_ChIP-Seq_MCF-7_Human0.90588390
138HOXB4_20404135_ChIP-ChIP_EML_Mouse0.90148985
139AR_21909140_ChIP-Seq_LNCAP_Human0.90047583
140ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.88431999
141EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.87987427

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.43599255
2MP0008007_abnormal_cellular_replicative3.12843860
3MP0010094_abnormal_chromosome_stability2.85905856
4MP0006292_abnormal_olfactory_placode2.78317180
5MP0000566_synostosis2.71704273
6MP0005670_abnormal_white_adipose2.67327088
7MP0008058_abnormal_DNA_repair2.63585576
8MP0008877_abnormal_DNA_methylation2.58606232
9MP0003787_abnormal_imprinting2.56882186
10MP0002102_abnormal_ear_morphology2.45190613
11MP0001348_abnormal_lacrimal_gland2.24474253
12MP0001188_hyperpigmentation2.23242977
13MP0010030_abnormal_orbit_morphology2.19276758
14MP0003111_abnormal_nucleus_morphology2.18698199
15MP0003880_abnormal_central_pattern2.06366615
16MP0004233_abnormal_muscle_weight2.04984458
17MP0005551_abnormal_eye_electrophysiolog2.01623155
18MP0009697_abnormal_copulation2.00494393
19MP0003077_abnormal_cell_cycle1.89907812
20MP0000569_abnormal_digit_pigmentation1.85492601
21MP0003693_abnormal_embryo_hatching1.83216410
22MP0003950_abnormal_plasma_membrane1.82768695
23MP0003890_abnormal_embryonic-extraembry1.77794636
24MP0003121_genomic_imprinting1.76386340
25MP0001968_abnormal_touch/_nociception1.74324920
26MP0003786_premature_aging1.72759663
27MP0009745_abnormal_behavioral_response1.61836514
28MP0003646_muscle_fatigue1.56536504
29MP0001984_abnormal_olfaction1.56181505
30MP0002736_abnormal_nociception_after1.55567517
31MP0002396_abnormal_hematopoietic_system1.54566679
32MP0008995_early_reproductive_senescence1.54312352
33MP0006072_abnormal_retinal_apoptosis1.52413146
34MP0008789_abnormal_olfactory_epithelium1.51079370
35MP0004142_abnormal_muscle_tone1.49220379
36MP0003195_calcinosis1.46834483
37MP0000427_abnormal_hair_cycle1.46587416
38MP0002653_abnormal_ependyma_morphology1.45771129
39MP0003136_yellow_coat_color1.44669001
40MP0002234_abnormal_pharynx_morphology1.43296524
41MP0004957_abnormal_blastocyst_morpholog1.40880309
42MP0004133_heterotaxia1.39892072
43MP0005645_abnormal_hypothalamus_physiol1.39383126
44MP0005253_abnormal_eye_physiology1.39248969
45MP0002837_dystrophic_cardiac_calcinosis1.36602075
46MP0004147_increased_porphyrin_level1.35414896
47MP0002638_abnormal_pupillary_reflex1.34967953
48MP0006276_abnormal_autonomic_nervous1.33929040
49MP0004742_abnormal_vestibular_system1.29646413
50MP0010368_abnormal_lymphatic_system1.28906385
51MP0001529_abnormal_vocalization1.27984289
52MP0003122_maternal_imprinting1.27714376
53MP0002160_abnormal_reproductive_system1.27219007
54MP0005174_abnormal_tail_pigmentation1.27023448
55MP0005075_abnormal_melanosome_morpholog1.25956127
56MP0003385_abnormal_body_wall1.25275953
57MP0002168_other_aberrant_phenotype1.22725397
58MP0002751_abnormal_autonomic_nervous1.22099926
59MP0000015_abnormal_ear_pigmentation1.21785694
60MP0008872_abnormal_physiological_respon1.21408788
61MP0003879_abnormal_hair_cell1.21149205
62MP0000372_irregular_coat_pigmentation1.20965296
63MP0001346_abnormal_lacrimal_gland1.20548122
64MP0000428_abnormal_craniofacial_morphol1.19792295
65MP0002067_abnormal_sensory_capabilities1.18961183
66MP0002735_abnormal_chemical_nociception1.18737727
67MP0001929_abnormal_gametogenesis1.14968711
68MP0002572_abnormal_emotion/affect_behav1.12008424
69MP0002095_abnormal_skin_pigmentation1.11623107
70MP0002557_abnormal_social/conspecific_i1.08477190
71MP0001986_abnormal_taste_sensitivity1.08107400
72MP0001486_abnormal_startle_reflex1.07745234
73MP0005394_taste/olfaction_phenotype1.06295435
74MP0005499_abnormal_olfactory_system1.06295435
75MP0005386_behavior/neurological_phenoty1.05839494
76MP0004924_abnormal_behavior1.05839494
77MP0000013_abnormal_adipose_tissue1.04137866
78MP0003698_abnormal_male_reproductive1.03284370
79MP0001501_abnormal_sleep_pattern1.03270703
80MP0001485_abnormal_pinna_reflex1.02897723
81MP0003937_abnormal_limbs/digits/tail_de1.01008426
82MP0003635_abnormal_synaptic_transmissio1.00996420
83MP0003119_abnormal_digestive_system1.00218846
84MP0004145_abnormal_muscle_electrophysio0.99228511
85MP0002064_seizures0.98726226
86MP0002277_abnormal_respiratory_mucosa0.98212742
87MP0005395_other_phenotype0.98069470
88MP0000631_abnormal_neuroendocrine_gland0.97090095
89MP0002210_abnormal_sex_determination0.96023860
90MP0004134_abnormal_chest_morphology0.94674207
91MP0005248_abnormal_Harderian_gland0.94563051
92MP0002938_white_spotting0.93653702
93MP0004043_abnormal_pH_regulation0.93636145
94MP0005389_reproductive_system_phenotype0.93269961
95MP0004808_abnormal_hematopoietic_stem0.93263109
96MP0008932_abnormal_embryonic_tissue0.93066681
97MP0005391_vision/eye_phenotype0.92465590
98MP0004215_abnormal_myocardial_fiber0.92253182
99MP0005171_absent_coat_pigmentation0.91447776
100MP0005646_abnormal_pituitary_gland0.89898304
101MP0003763_abnormal_thymus_physiology0.89540666
102MP0004084_abnormal_cardiac_muscle0.89416450
103MP0000049_abnormal_middle_ear0.89381002
104MP0003984_embryonic_growth_retardation0.88213644
105MP0002088_abnormal_embryonic_growth/wei0.87613838
106MP0003942_abnormal_urinary_system0.87534805
107MP0002752_abnormal_somatic_nervous0.87496824
108MP0000383_abnormal_hair_follicle0.87229201
109MP0001730_embryonic_growth_arrest0.86025940
110MP0001502_abnormal_circadian_rhythm0.85853809
111MP0005380_embryogenesis_phenotype0.84965450
112MP0001672_abnormal_embryogenesis/_devel0.84965450
113MP0002928_abnormal_bile_duct0.84712558
114MP0003878_abnormal_ear_physiology0.84532219
115MP0005377_hearing/vestibular/ear_phenot0.84532219
116MP0003755_abnormal_palate_morphology0.84507859
117MP0002063_abnormal_learning/memory/cond0.83882137
118MP0000350_abnormal_cell_proliferation0.82416482
119MP0008875_abnormal_xenobiotic_pharmacok0.82158218
120MP0000647_abnormal_sebaceous_gland0.81686427
121MP0001293_anophthalmia0.81595306
122MP0000778_abnormal_nervous_system0.81499805
123MP0005195_abnormal_posterior_eye0.81387515
124MP0000955_abnormal_spinal_cord0.81289241
125MP0002282_abnormal_trachea_morphology0.81285719
126MP0010386_abnormal_urinary_bladder0.80973921
127MP0001145_abnormal_male_reproductive0.79882864
128MP0001697_abnormal_embryo_size0.79755509
129MP0002734_abnormal_mechanical_nocicepti0.79742630
130MP0003567_abnormal_fetal_cardiomyocyte0.79212650
131MP0001970_abnormal_pain_threshold0.79110233
132MP0003137_abnormal_impulse_conducting0.78995824
133MP0002272_abnormal_nervous_system0.78501375
134MP0002084_abnormal_developmental_patter0.78213046
135MP0004885_abnormal_endolymph0.78135230
136MP0002085_abnormal_embryonic_tissue0.78043869
137MP0003943_abnormal_hepatobiliary_system0.77767634
138MP0000026_abnormal_inner_ear0.77659613
139MP0003718_maternal_effect0.77237838
140MP0000653_abnormal_sex_gland0.74882978
141MP0000534_abnormal_ureter_morphology0.74751650
142MP0005379_endocrine/exocrine_gland_phen0.74136484
143MP0005410_abnormal_fertilization0.73547112
144MP0009046_muscle_twitch0.72728321
145MP0005409_darkened_coat_color0.72717150
146MP0002177_abnormal_outer_ear0.72604528
147MP0005503_abnormal_tendon_morphology0.71567469

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic fibrosis (HP:0100732)4.40606510
2Volvulus (HP:0002580)4.09113587
3Abnormal hair whorl (HP:0010721)4.07951138
4Congenital stationary night blindness (HP:0007642)4.05410930
5Selective tooth agenesis (HP:0001592)4.05080024
6Chronic hepatic failure (HP:0100626)3.64969249
7True hermaphroditism (HP:0010459)3.45774944
8Pancreatic cysts (HP:0001737)3.20475148
9Molar tooth sign on MRI (HP:0002419)3.10691126
10Abnormality of midbrain morphology (HP:0002418)3.10691126
11Aplasia/Hypoplasia of the tongue (HP:0010295)3.07457842
12Medial flaring of the eyebrow (HP:0010747)3.03406827
13Nephronophthisis (HP:0000090)2.97968386
14Type II lissencephaly (HP:0007260)2.95352790
15Postaxial foot polydactyly (HP:0001830)2.95083949
16Congenital primary aphakia (HP:0007707)2.88157320
17Abnormality of the labia minora (HP:0012880)2.87018383
18Hyperventilation (HP:0002883)2.85333311
19Gait imbalance (HP:0002141)2.74900100
20Abnormal ciliary motility (HP:0012262)2.67469661
21Nephrogenic diabetes insipidus (HP:0009806)2.67432172
22Severe visual impairment (HP:0001141)2.61305517
23Chromosomal breakage induced by crosslinking agents (HP:0003221)2.61237980
24Abnormal respiratory epithelium morphology (HP:0012253)2.59083858
25Abnormal respiratory motile cilium morphology (HP:0005938)2.59083858
26Gaze-evoked nystagmus (HP:0000640)2.57935028
27Tubulointerstitial nephritis (HP:0001970)2.57152315
28Syringomyelia (HP:0003396)2.56991529
29Spinal cord lesions (HP:0100561)2.56991529
30Chromsome breakage (HP:0040012)2.54479882
31Abnormality of the renal medulla (HP:0100957)2.53897436
32Poor coordination (HP:0002370)2.52548556
33Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.48510266
34Ectopic kidney (HP:0000086)2.47834421
35Intestinal atresia (HP:0011100)2.46708287
36Long clavicles (HP:0000890)2.43521998
37Short 4th metacarpal (HP:0010044)2.43268288
38Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.43268288
39Sloping forehead (HP:0000340)2.41155688
40Progressive cerebellar ataxia (HP:0002073)2.39284352
41Growth hormone deficiency (HP:0000824)2.30669564
42Abnormality of chromosome stability (HP:0003220)2.27131184
43Aplasia/Hypoplasia of the uvula (HP:0010293)2.26720960
44Increased corneal curvature (HP:0100692)2.26206813
45Keratoconus (HP:0000563)2.26206813
4611 pairs of ribs (HP:0000878)2.25886277
47Facial hemangioma (HP:0000329)2.25795704
48Median cleft lip (HP:0000161)2.25754192
49Preaxial hand polydactyly (HP:0001177)2.23352144
50Abnormality of the preputium (HP:0100587)2.23245509
51Abnormality of DNA repair (HP:0003254)2.21598462
52Broad-based gait (HP:0002136)2.20362893
53Occipital encephalocele (HP:0002085)2.17379817
54Genital tract atresia (HP:0001827)2.14741088
55Colon cancer (HP:0003003)2.14242417
56Postaxial hand polydactyly (HP:0001162)2.08489503
57Febrile seizures (HP:0002373)2.08079251
58Congenital hepatic fibrosis (HP:0002612)2.07806598
59Decreased testicular size (HP:0008734)2.05030625
60Cystic liver disease (HP:0006706)2.04263323
61Sclerocornea (HP:0000647)2.04076424
62Tubular atrophy (HP:0000092)2.03083746
63Meckel diverticulum (HP:0002245)2.02730786
64Decreased central vision (HP:0007663)2.00653369
65Gastrointestinal atresia (HP:0002589)2.00648470
66Anencephaly (HP:0002323)2.00382473
67Methylmalonic acidemia (HP:0002912)1.99736302
68Polydipsia (HP:0001959)1.99733849
69Abnormal drinking behavior (HP:0030082)1.99733849
70Aplasia/Hypoplasia of the tibia (HP:0005772)1.99722208
713-Methylglutaconic aciduria (HP:0003535)1.99365838
72Genetic anticipation (HP:0003743)1.99027723
73Small hand (HP:0200055)1.98269020
74Lissencephaly (HP:0001339)1.98254617
75Abnormality of macular pigmentation (HP:0008002)1.97916259
76Increased hepatocellular lipid droplets (HP:0006565)1.97733047
77Astigmatism (HP:0000483)1.97101459
78Abnormality of the renal cortex (HP:0011035)1.94891926
79Short tibia (HP:0005736)1.94809384
80Retinal dysplasia (HP:0007973)1.93897138
81Oligodactyly (hands) (HP:0001180)1.93842975
82Bony spicule pigmentary retinopathy (HP:0007737)1.93363248
83Stomach cancer (HP:0012126)1.92037386
84Type I transferrin isoform profile (HP:0003642)1.92025382
85Vaginal atresia (HP:0000148)1.91699650
86Central scotoma (HP:0000603)1.91500614
87Congenital, generalized hypertrichosis (HP:0004540)1.91467847
88Abnormality of the ileum (HP:0001549)1.90989914
89Duodenal stenosis (HP:0100867)1.90805367
90Small intestinal stenosis (HP:0012848)1.90805367
91Microglossia (HP:0000171)1.90714234
92Male pseudohermaphroditism (HP:0000037)1.90650492
93Rough bone trabeculation (HP:0100670)1.90610667
94Septo-optic dysplasia (HP:0100842)1.90155169
95Abnormal lung lobation (HP:0002101)1.89636054
96Drooling (HP:0002307)1.89430081
97Bile duct proliferation (HP:0001408)1.88817232
98Abnormal biliary tract physiology (HP:0012439)1.88817232
99Attenuation of retinal blood vessels (HP:0007843)1.86653000
100Renal cortical cysts (HP:0000803)1.86538896
101Lipid accumulation in hepatocytes (HP:0006561)1.86457918
102Asymmetry of the thorax (HP:0001555)1.86312706
103Abnormal rod and cone electroretinograms (HP:0008323)1.85492555
104Optic nerve hypoplasia (HP:0000609)1.84857374
105Degeneration of anterior horn cells (HP:0002398)1.82871681
106Abnormality of the anterior horn cell (HP:0006802)1.82871681
107Abolished electroretinogram (ERG) (HP:0000550)1.82584622
108Patent foramen ovale (HP:0001655)1.81661639
109Duplicated collecting system (HP:0000081)1.81581570
110Deep philtrum (HP:0002002)1.81305952
111Absent/shortened dynein arms (HP:0200106)1.81174434
112Dynein arm defect of respiratory motile cilia (HP:0012255)1.81174434
113Inability to walk (HP:0002540)1.80796969
114Fair hair (HP:0002286)1.80584716
115Narrow forehead (HP:0000341)1.80307258
116Nephroblastoma (Wilms tumor) (HP:0002667)1.79324847
117Cutaneous melanoma (HP:0012056)1.79202936
118Myelodysplasia (HP:0002863)1.78744133
119Focal motor seizures (HP:0011153)1.77978251
120Meningioma (HP:0002858)1.77553762
121Abnormality of alanine metabolism (HP:0010916)1.76921294
122Hyperalaninemia (HP:0003348)1.76921294
123Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.76921294
124Oligodontia (HP:0000677)1.76837035
125Rhinitis (HP:0012384)1.76267637
126Abnormal respiratory motile cilium physiology (HP:0012261)1.76245306
127Aganglionic megacolon (HP:0002251)1.75471325
128Pendular nystagmus (HP:0012043)1.74512751
129Clubbing of toes (HP:0100760)1.74271948
130Birth length less than 3rd percentile (HP:0003561)1.73640581
131Thyroiditis (HP:0100646)1.73458608
132Furrowed tongue (HP:0000221)1.73146143
133Panhypogammaglobulinemia (HP:0003139)1.72263174
134Absent speech (HP:0001344)1.71588148
135Truncal obesity (HP:0001956)1.71570969
136Progressive inability to walk (HP:0002505)1.70977908
137Excessive salivation (HP:0003781)1.70337824
138Mitochondrial inheritance (HP:0001427)1.70026466
139Benign neoplasm of the central nervous system (HP:0100835)1.69852910
140Poikiloderma (HP:0001029)1.69788596
141Dandy-Walker malformation (HP:0001305)1.69497052
142Abnormality of the right ventricle (HP:0001707)1.69095630
143Embryonal renal neoplasm (HP:0011794)1.69055355
144Hypochromic microcytic anemia (HP:0004840)1.68787785
145Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.68600650
146Oculomotor apraxia (HP:0000657)1.68569632
147Increased CSF lactate (HP:0002490)1.67675483
148Multicystic kidney dysplasia (HP:0000003)1.67105659
149Fibular hypoplasia (HP:0003038)1.66708591
150Abnormality of the phalanges of the hallux (HP:0010057)1.66529224
151Optic nerve coloboma (HP:0000588)1.66528951

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR1B5.30186198
2FRK4.60054275
3SIK34.42172180
4BRSK23.50524456
5MAP4K23.06960583
6WNK32.53355991
7SRPK12.37861918
8TGFBR12.37560480
9ZAK2.17196413
10CASK2.15378579
11WEE12.15373304
12AKT32.13745276
13TSSK62.04249296
14CDC72.04017799
15BRSK11.81604601
16ADRBK21.81485496
17ERBB31.78190103
18PLK31.76945275
19ACVR1B1.73093781
20PNCK1.70993819
21CDK81.59161228
22NEK21.52735077
23TNIK1.45225240
24MKNK11.43636684
25NUAK11.42169816
26BCR1.41855969
27TLK11.39909567
28PLK41.39257640
29BRD41.39186341
30INSRR1.37428015
31MST41.34373462
32GRK11.33477636
33VRK11.33104069
34MARK11.32789134
35STK38L1.32281180
36MAP2K71.31700789
37STK161.30712500
38ATR1.27882551
39NEK11.26482259
40BUB11.25528434
41OXSR11.25385304
42PDK21.20537881
43PINK11.20206852
44CDK121.18970024
45TEC1.18817584
46PIK3CA1.18466577
47EIF2AK31.18357386
48PDK31.16204523
49PDK41.16204523
50CDK191.15728548
51PLK11.13083699
52FGFR21.09890133
53CHEK21.09157241
54PAK31.08047145
55NEK61.07772773
56TRIM281.07687609
57PASK1.05638982
58MAPK151.05076637
59SGK21.00095123
60BMPR20.98490633
61PRPF4B0.97138867
62CHEK10.96402705
63DYRK20.94698112
64YES10.93184717
65CAMKK20.91825504
66TTK0.88178380
67NEK90.85818099
68EIF2AK10.82687667
69STK390.82100106
70PLK20.79789390
71MAPK100.78227754
72MKNK20.77372532
73ATM0.75765938
74WNK40.75194603
75KIT0.72766419
76CDC42BPA0.72636796
77MUSK0.72392888
78NLK0.72354336
79PRKCG0.70394743
80MAP3K40.70244262
81SIK20.69907443
82DYRK30.69497782
83STK240.69211287
84CSNK1G20.69101113
85TAF10.68345990
86CDK10.67540824
87CDK30.66344043
88MAPK130.65965539
89EIF2AK20.64725828
90PRKCE0.64683632
91ADRBK10.64150378
92CDK20.63860178
93RPS6KA40.63566596
94CCNB10.61452114
95TIE10.61194683
96DYRK1A0.59433728
97SGK2230.58065699
98SGK4940.58065699
99CDK70.57788863
100AURKB0.56770086
101CHUK0.55098414
102BRAF0.53723893
103EPHA40.52070944
104MELK0.51818182
105NME10.51778736
106EPHA30.50936804
107CSNK1G30.50820960
108NTRK20.50388041
109CSNK1A1L0.48346657
110MAP2K40.47018056
111TAOK30.46062466
112PRKCQ0.44894400
113GSK3B0.44893777
114ITK0.44829194
115DYRK1B0.44763721
116CAMK1G0.44482778
117CSNK1G10.44379640
118CDK90.43045478
119STK30.42819463
120TRPM70.42590169
121PKN10.42355011
122CSNK1D0.42192919
123MAPK140.42041726
124CAMK2A0.42035757
125DAPK20.42011973
126NTRK30.40845295
127RPS6KA50.40368848
128UHMK10.39447831
129PRKDC0.39390197
130MAPK90.39279621
131CAMK40.39278879
132PRKG10.38445986
133MAPK80.38118504
134OBSCN0.38081644
135RPS6KB10.38014479
136CDK60.37548016
137TXK0.37042165
138PRKACA0.36978849
139MARK30.35082417
140PTK2B0.34883763
141CSNK2A10.33901538
142CSNK2A20.31728943

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034302.77545107
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.74471675
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.73611856
4Base excision repair_Homo sapiens_hsa034102.67563020
5Spliceosome_Homo sapiens_hsa030402.59172211
6Fanconi anemia pathway_Homo sapiens_hsa034602.48342893
7DNA replication_Homo sapiens_hsa030302.45111384
8Cell cycle_Homo sapiens_hsa041102.41890444
9Homologous recombination_Homo sapiens_hsa034402.32510250
10RNA degradation_Homo sapiens_hsa030182.27422110
11Nicotine addiction_Homo sapiens_hsa050332.26732561
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.14156849
13Oxidative phosphorylation_Homo sapiens_hsa001902.13487477
14RNA polymerase_Homo sapiens_hsa030202.12105921
15Nucleotide excision repair_Homo sapiens_hsa034202.10489810
16Phototransduction_Homo sapiens_hsa047442.09178691
17Basal transcription factors_Homo sapiens_hsa030222.08036852
18RNA transport_Homo sapiens_hsa030131.97473867
19Selenocompound metabolism_Homo sapiens_hsa004501.89423537
20Butanoate metabolism_Homo sapiens_hsa006501.87660316
21Non-homologous end-joining_Homo sapiens_hsa034501.75433821
22Linoleic acid metabolism_Homo sapiens_hsa005911.73701919
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.70070100
24Parkinsons disease_Homo sapiens_hsa050121.69329630
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.61351009
26Propanoate metabolism_Homo sapiens_hsa006401.57671856
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.56191247
28Nitrogen metabolism_Homo sapiens_hsa009101.55961773
29Synaptic vesicle cycle_Homo sapiens_hsa047211.55871060
30Circadian rhythm_Homo sapiens_hsa047101.54247008
31mRNA surveillance pathway_Homo sapiens_hsa030151.53156679
32Huntingtons disease_Homo sapiens_hsa050161.51184526
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.46802650
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43942416
35Caffeine metabolism_Homo sapiens_hsa002321.41602992
36Purine metabolism_Homo sapiens_hsa002301.34112608
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34074876
38Morphine addiction_Homo sapiens_hsa050321.34034778
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.25566242
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25429045
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.24986789
42Oocyte meiosis_Homo sapiens_hsa041141.22634366
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.17562277
44Proteasome_Homo sapiens_hsa030501.16601691
45Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.14472861
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11701215
47Pyrimidine metabolism_Homo sapiens_hsa002401.08969353
48Olfactory transduction_Homo sapiens_hsa047401.07673048
49Ether lipid metabolism_Homo sapiens_hsa005651.07020291
50Tryptophan metabolism_Homo sapiens_hsa003801.04685618
51GABAergic synapse_Homo sapiens_hsa047271.01988879
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01241937
53Alzheimers disease_Homo sapiens_hsa050100.99637082
54Epstein-Barr virus infection_Homo sapiens_hsa051690.99626309
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96636777
56Primary immunodeficiency_Homo sapiens_hsa053400.95240933
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93405223
58Collecting duct acid secretion_Homo sapiens_hsa049660.93348416
59Cardiac muscle contraction_Homo sapiens_hsa042600.92154376
60Serotonergic synapse_Homo sapiens_hsa047260.89653421
61Chemical carcinogenesis_Homo sapiens_hsa052040.89647840
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.87404162
63Circadian entrainment_Homo sapiens_hsa047130.87006044
64Protein export_Homo sapiens_hsa030600.86935427
65N-Glycan biosynthesis_Homo sapiens_hsa005100.85159154
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83592071
67Dorso-ventral axis formation_Homo sapiens_hsa043200.81723181
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79023594
69Retinol metabolism_Homo sapiens_hsa008300.77288207
70Peroxisome_Homo sapiens_hsa041460.77053622
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.76145128
72Ovarian steroidogenesis_Homo sapiens_hsa049130.75754933
73Herpes simplex infection_Homo sapiens_hsa051680.75741249
74p53 signaling pathway_Homo sapiens_hsa041150.75186619
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.74687918
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.74577251
77Alcoholism_Homo sapiens_hsa050340.74494658
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72061125
79ABC transporters_Homo sapiens_hsa020100.70194588
80One carbon pool by folate_Homo sapiens_hsa006700.69951079
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69662092
82Wnt signaling pathway_Homo sapiens_hsa043100.69515191
83HTLV-I infection_Homo sapiens_hsa051660.68879440
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68458747
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67438800
86Insulin secretion_Homo sapiens_hsa049110.66418348
87Fructose and mannose metabolism_Homo sapiens_hsa000510.66322656
88Colorectal cancer_Homo sapiens_hsa052100.64459345
89Amphetamine addiction_Homo sapiens_hsa050310.61445018
90Calcium signaling pathway_Homo sapiens_hsa040200.61398890
91Glutamatergic synapse_Homo sapiens_hsa047240.61367735
92Dilated cardiomyopathy_Homo sapiens_hsa054140.61199894
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59308030
94MicroRNAs in cancer_Homo sapiens_hsa052060.58221764
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58039956
96Steroid biosynthesis_Homo sapiens_hsa001000.56443104
97Cholinergic synapse_Homo sapiens_hsa047250.55827863
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54130914
99Regulation of autophagy_Homo sapiens_hsa041400.53315453
100Adherens junction_Homo sapiens_hsa045200.53142363
101Hedgehog signaling pathway_Homo sapiens_hsa043400.52701831
102Prostate cancer_Homo sapiens_hsa052150.52590295
103FoxO signaling pathway_Homo sapiens_hsa040680.52575162
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52322587
105Oxytocin signaling pathway_Homo sapiens_hsa049210.51220030
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49983650
107beta-Alanine metabolism_Homo sapiens_hsa004100.49826400
108Viral carcinogenesis_Homo sapiens_hsa052030.49745261
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49365295
110TGF-beta signaling pathway_Homo sapiens_hsa043500.48893375
111Inositol phosphate metabolism_Homo sapiens_hsa005620.48867360
112Hematopoietic cell lineage_Homo sapiens_hsa046400.48671244
113Salivary secretion_Homo sapiens_hsa049700.48429560
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47959405
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47689717
116Taste transduction_Homo sapiens_hsa047420.47676460
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47356581
118Dopaminergic synapse_Homo sapiens_hsa047280.47149870
119Metabolic pathways_Homo sapiens_hsa011000.46917097
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.46491014
121Ribosome_Homo sapiens_hsa030100.46001344
122Long-term potentiation_Homo sapiens_hsa047200.43896989
123Type I diabetes mellitus_Homo sapiens_hsa049400.43758125
124cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43654314
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.42783124
126Glycerolipid metabolism_Homo sapiens_hsa005610.42775914
127Cocaine addiction_Homo sapiens_hsa050300.42608365
128Melanoma_Homo sapiens_hsa052180.42214384
129Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42163449
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41653500
131Lysine degradation_Homo sapiens_hsa003100.40383116
132Thyroid cancer_Homo sapiens_hsa052160.40360948
133Cysteine and methionine metabolism_Homo sapiens_hsa002700.39923303
134MAPK signaling pathway_Homo sapiens_hsa040100.37534929
135Hippo signaling pathway_Homo sapiens_hsa043900.37523497
136Long-term depression_Homo sapiens_hsa047300.36720378
137Fatty acid biosynthesis_Homo sapiens_hsa000610.36379220
138Glucagon signaling pathway_Homo sapiens_hsa049220.36022331
139cAMP signaling pathway_Homo sapiens_hsa040240.35597845
140Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35243575
141Gap junction_Homo sapiens_hsa045400.34739455
142Renin secretion_Homo sapiens_hsa049240.34151052
143Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33967070
144Pathways in cancer_Homo sapiens_hsa052000.33863492
145Antigen processing and presentation_Homo sapiens_hsa046120.33791777
146Asthma_Homo sapiens_hsa053100.33609915
147Basal cell carcinoma_Homo sapiens_hsa052170.32925761
148Axon guidance_Homo sapiens_hsa043600.32356251
149Systemic lupus erythematosus_Homo sapiens_hsa053220.32275694
150Autoimmune thyroid disease_Homo sapiens_hsa053200.31716333

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