CCDC67

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane fusion (GO:0045026)9.99660582
2acrosome reaction (GO:0007340)9.80863381
3cell-cell recognition (GO:0009988)9.16248695
4binding of sperm to zona pellucida (GO:0007339)8.95409164
5reproduction (GO:0000003)8.90881388
6regulation of cilium movement (GO:0003352)8.51260485
7spermatid development (GO:0007286)8.34774450
8single fertilization (GO:0007338)7.15129214
9male meiosis (GO:0007140)6.82233316
10piRNA metabolic process (GO:0034587)6.65499173
11sperm capacitation (GO:0048240)6.43015519
12* centriole assembly (GO:0098534)6.01842060
13male meiosis I (GO:0007141)5.97564218
14synaptonemal complex organization (GO:0070193)5.95372522
15fertilization (GO:0009566)5.83532999
16microtubule depolymerization (GO:0007019)5.79961861
17spermatogenesis (GO:0007283)5.75721091
18male gamete generation (GO:0048232)5.73665619
19synaptonemal complex assembly (GO:0007130)5.57533013
20centriole replication (GO:0007099)5.52661513
21ventricular system development (GO:0021591)5.50268254
22organic cation transport (GO:0015695)5.34276413
23gamete generation (GO:0007276)5.29739433
24cellular ketone body metabolic process (GO:0046950)5.28266873
25negative regulation of inclusion body assembly (GO:0090084)5.19461107
26protein targeting to Golgi (GO:0000042)5.05817010
27establishment of protein localization to Golgi (GO:0072600)4.98321545
28meiosis I (GO:0007127)4.82284084
29regulation of type B pancreatic cell apoptotic process (GO:2000674)4.80611475
30endocrine pancreas development (GO:0031018)4.77663893
31axoneme assembly (GO:0035082)4.76700459
32regulation of microtubule-based movement (GO:0060632)4.67217801
33calcium ion-dependent exocytosis (GO:0017156)4.64549898
34cellular process involved in reproduction in multicellular organism (GO:0022412)4.63903770
35germ cell development (GO:0007281)4.63890935
36retrograde transport, vesicle recycling within Golgi (GO:0000301)4.63837685
37ketone body metabolic process (GO:1902224)4.63721112
38regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.61488705
39cell recognition (GO:0008037)4.50779201
40intraciliary transport (GO:0042073)4.46442376
41DNA methylation involved in gamete generation (GO:0043046)4.46178856
42positive regulation of glycolytic process (GO:0045821)4.42747500
43cilium organization (GO:0044782)4.39284090
44cilium assembly (GO:0042384)4.35664145
45spermatid nucleus differentiation (GO:0007289)4.35602234
46regulation of inclusion body assembly (GO:0090083)4.34819994
47protein localization to Golgi apparatus (GO:0034067)4.23181771
48GTP biosynthetic process (GO:0006183)4.23018357
49meiotic nuclear division (GO:0007126)4.22881169
50multicellular organismal reproductive process (GO:0048609)4.16194339
51regulation of hexokinase activity (GO:1903299)4.09628627
52regulation of glucokinase activity (GO:0033131)4.09628627
53chromosome organization involved in meiosis (GO:0070192)4.09175346
54seminiferous tubule development (GO:0072520)4.08453557
55negative regulation of hormone biosynthetic process (GO:0032353)4.07933071
56nucleoside diphosphate phosphorylation (GO:0006165)4.01653259
57microtubule severing (GO:0051013)3.99516611
58protein polyglutamylation (GO:0018095)3.89406286
59negative regulation of cytosolic calcium ion concentration (GO:0051481)3.88602755
60glycerol ether metabolic process (GO:0006662)3.86957713
61left/right pattern formation (GO:0060972)3.85547610
62protein refolding (GO:0042026)3.85484394
63cellular component assembly involved in morphogenesis (GO:0010927)3.78654995
64negative regulation of acute inflammatory response (GO:0002674)3.77739543
65protein K11-linked deubiquitination (GO:0035871)3.75108191
66negative regulation of gluconeogenesis (GO:0045721)3.69123430
67UTP biosynthetic process (GO:0006228)3.63648073
68ether metabolic process (GO:0018904)3.59813571
69single strand break repair (GO:0000012)3.58256170
70negative regulation of protein oligomerization (GO:0032460)3.57875217
71regulation of centriole replication (GO:0046599)3.53398546
72cilium morphogenesis (GO:0060271)3.52778158
73detection of calcium ion (GO:0005513)3.51135401
74intra-Golgi vesicle-mediated transport (GO:0006891)3.50888756
75protein localization to cilium (GO:0061512)3.50191421
76protein K6-linked ubiquitination (GO:0085020)3.45479144
77negative regulation of hormone metabolic process (GO:0032351)3.41062231
78water-soluble vitamin biosynthetic process (GO:0042364)3.40454787
79meiotic cell cycle (GO:0051321)3.38979046
80positive regulation of meiosis (GO:0045836)3.38279439
81inositol phosphate catabolic process (GO:0071545)3.36267432
82nitric oxide mediated signal transduction (GO:0007263)3.35750490
83negative regulation of glycogen metabolic process (GO:0070874)3.35494316
84microtubule-based movement (GO:0007018)3.34315463
85polyketide metabolic process (GO:0030638)3.31237021
86doxorubicin metabolic process (GO:0044598)3.31237021
87daunorubicin metabolic process (GO:0044597)3.31237021
88insulin secretion (GO:0030073)3.29663831
89positive regulation of respiratory burst (GO:0060267)3.28408189
90sphingomyelin metabolic process (GO:0006684)3.27504876
91type B pancreatic cell development (GO:0003323)3.24851771
92UTP metabolic process (GO:0046051)3.24121684
93multicellular organismal development (GO:0007275)3.19895216
94gene silencing by RNA (GO:0031047)3.16674569
95epithelial cell fate commitment (GO:0072148)3.15463842
96positive regulation of meiotic cell cycle (GO:0051446)3.15406399
97chromosome condensation (GO:0030261)3.12209362
98resolution of meiotic recombination intermediates (GO:0000712)3.12117127
99DNA packaging (GO:0006323)3.10321339
100CTP metabolic process (GO:0046036)3.10117671
101CTP biosynthetic process (GO:0006241)3.10117671
102nephron epithelium morphogenesis (GO:0072088)3.09994665
103nephron tubule morphogenesis (GO:0072078)3.09994665
104inositol phosphate dephosphorylation (GO:0046855)3.09264348
105phosphorylated carbohydrate dephosphorylation (GO:0046838)3.09264348
106lactate metabolic process (GO:0006089)3.06151377
107microtubule polymerization or depolymerization (GO:0031109)3.06101149
108glycerophospholipid catabolic process (GO:0046475)3.01819429
109signal peptide processing (GO:0006465)3.01275656
110monoubiquitinated protein deubiquitination (GO:0035520)2.97995924
111mesenchymal cell differentiation involved in kidney development (GO:0072161)2.97561047
112mesenchymal cell differentiation involved in renal system development (GO:2001012)2.97561047
113positive regulation of insulin secretion (GO:0032024)2.96446683
114positive regulation of peptide hormone secretion (GO:0090277)2.96303001
115peptide hormone processing (GO:0016486)2.95272781
116chaperone-mediated protein complex assembly (GO:0051131)2.93582333
117glandular epithelial cell differentiation (GO:0002067)2.92000755
118xenobiotic catabolic process (GO:0042178)2.91188155
119positive regulation of peptide secretion (GO:0002793)2.88402256
120left/right axis specification (GO:0070986)2.88279687
121fatty acid homeostasis (GO:0055089)2.86853022
122guanosine-containing compound biosynthetic process (GO:1901070)2.86770894
123pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.85046491
124cellular zinc ion homeostasis (GO:0006882)2.83322473
125synapsis (GO:0007129)2.83232384
126genitalia morphogenesis (GO:0035112)2.82325647
127meiotic cell cycle process (GO:1903046)2.81463311
128limb development (GO:0060173)2.78242048
129appendage development (GO:0048736)2.78242048
130regulation of spindle checkpoint (GO:0090231)2.77916674
131negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.76786126
132pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.74106175
133protein prenylation (GO:0018342)2.73587934
134prenylation (GO:0097354)2.73587934
135spinal cord motor neuron differentiation (GO:0021522)2.71763664
136cell projection assembly (GO:0030031)2.70913022
137polyol catabolic process (GO:0046174)2.69950715
138calcium ion import (GO:0070509)2.69052285
139potassium ion export (GO:0071435)2.67754336
140alditol metabolic process (GO:0019400)2.66090978
141positive regulation of protein autophosphorylation (GO:0031954)2.64549473
142Golgi to endosome transport (GO:0006895)2.63990369
143sequestering of actin monomers (GO:0042989)2.60588357
144* organelle assembly (GO:0070925)2.54591327
145pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.50057752
146sister chromatid cohesion (GO:0007062)2.44335137
147pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.39436798
148motile cilium assembly (GO:0044458)14.1961929
149cilium or flagellum-dependent cell motility (GO:0001539)13.6351111
150axonemal dynein complex assembly (GO:0070286)13.1367289
151fusion of sperm to egg plasma membrane (GO:0007342)13.1287547
152cell wall macromolecule metabolic process (GO:0044036)12.5250931
153cell wall macromolecule catabolic process (GO:0016998)12.5250931
154sperm motility (GO:0030317)11.5640066
155epithelial cilium movement (GO:0003351)11.5206990
156multicellular organism reproduction (GO:0032504)10.7897799
157epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)10.5032391
158acrosome assembly (GO:0001675)10.4519732
159sperm-egg recognition (GO:0035036)10.2763207
160cilium movement (GO:0003341)10.1565005

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.06334583
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.62679495
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.24837400
4EZH2_22144423_ChIP-Seq_EOC_Human3.66405244
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.37883982
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.34127174
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.65737344
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.59410973
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.35157868
10PCGF2_27294783_Chip-Seq_ESCs_Mouse2.34408188
11IGF1R_20145208_ChIP-Seq_DFB_Human2.10690074
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.08382146
13ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96246354
14CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94475651
15ZNF274_21170338_ChIP-Seq_K562_Hela1.92762166
16EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.92143745
17KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.91249041
18GATA1_26923725_Chip-Seq_HPCs_Mouse1.87791132
19SUZ12_27294783_Chip-Seq_NPCs_Mouse1.81444675
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.81154079
21STAT3_23295773_ChIP-Seq_U87_Human1.80010714
22NFE2_27457419_Chip-Seq_LIVER_Mouse1.77842938
23TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.77696284
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.76379342
25KAP1_22055183_ChIP-Seq_ESCs_Mouse1.76374590
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72915987
27TAL1_26923725_Chip-Seq_HPCs_Mouse1.71732429
28ELK4_26923725_Chip-Seq_MESODERM_Mouse1.71226934
29STAT1_17558387_ChIP-Seq_HELA_Human1.70920345
30PIAS1_25552417_ChIP-Seq_VCAP_Human1.70549523
31AR_25329375_ChIP-Seq_VCAP_Human1.69908168
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.69824212
33TOP2B_26459242_ChIP-Seq_MCF-7_Human1.69037832
34TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.68743826
35VDR_22108803_ChIP-Seq_LS180_Human1.68414769
36MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.66458559
37RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.63498974
38TAF15_26573619_Chip-Seq_HEK293_Human1.58854230
39KDM2B_26808549_Chip-Seq_REH_Human1.58470003
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56665499
41* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56581670
42NANOG_18555785_Chip-Seq_ESCs_Mouse1.53265909
43EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.52441725
44BCAT_22108803_ChIP-Seq_LS180_Human1.50694120
45CDX2_22108803_ChIP-Seq_LS180_Human1.49877870
46CBP_20019798_ChIP-Seq_JUKART_Human1.49540311
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49540311
48WDR5_24793694_ChIP-Seq_LNCAP_Human1.49536590
49RNF2_27304074_Chip-Seq_NSC_Mouse1.48545318
50FOXA1_21572438_ChIP-Seq_LNCaP_Human1.46542009
51CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.46528799
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46024440
53* RUNX2_22187159_ChIP-Seq_PCA_Human1.45123140
54* NFYB_21822215_ChIP-Seq_K562_Human1.44844426
55OCT4_18555785_Chip-Seq_ESCs_Mouse1.44822098
56TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44535974
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.43683601
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.43683601
59P53_22387025_ChIP-Seq_ESCs_Mouse1.43353833
60CMYC_18555785_Chip-Seq_ESCs_Mouse1.42714398
61* PHF8_20622853_ChIP-Seq_HELA_Human1.41651605
62ETV1_20927104_ChIP-Seq_GIST48_Human1.41201478
63TBL1_22424771_ChIP-Seq_293T_Human1.39536456
64SUZ12_18555785_Chip-Seq_ESCs_Mouse1.39228508
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.38896308
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38741442
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.38741442
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.38669681
69PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.37760660
70ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37544386
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36144824
72P300_18555785_Chip-Seq_ESCs_Mouse1.35920204
73SMAD4_21741376_ChIP-Seq_EPCs_Human1.35446912
74EWS_26573619_Chip-Seq_HEK293_Human1.34519187
75* REST_21632747_ChIP-Seq_MESCs_Mouse1.34041227
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.33297432
77KLF4_18555785_Chip-Seq_ESCs_Mouse1.33219140
78GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.31991012
79RBPJ_21746931_ChIP-Seq_IB4_Human1.31751250
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30835899
81* HNFA_21074721_ChIP-Seq_CACO-2_Human1.30734990
82NFYA_21822215_ChIP-Seq_K562_Human1.30148924
83EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.29875898
84TP53_22573176_ChIP-Seq_HFKS_Human1.29318673
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.28675392
86TCF4_22108803_ChIP-Seq_LS180_Human1.28151731
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.27230860
88STAT3_18555785_Chip-Seq_ESCs_Mouse1.26876130
89SOX2_19829295_ChIP-Seq_ESCs_Human1.26627767
90NANOG_19829295_ChIP-Seq_ESCs_Human1.26627767
91PRDM14_20953172_ChIP-Seq_ESCs_Human1.25511318
92SOX2_22085726_ChIP-Seq_NPCs_Mouse1.25499011
93CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.24406195
94ESRRB_18555785_Chip-Seq_ESCs_Mouse1.23628542
95E2F1_18555785_Chip-Seq_ESCs_Mouse1.23622143
96CBX2_22325352_ChIP-Seq_293T-Rex_Human1.23130018
97SOX2_18555785_Chip-Seq_ESCs_Mouse1.23030498
98HTT_18923047_ChIP-ChIP_STHdh_Human1.22497465
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22152152
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21608942
101KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20428147
102SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19888487
103FUS_26573619_Chip-Seq_HEK293_Human1.19770343
104SMAD4_21799915_ChIP-Seq_A2780_Human1.19621728
105EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19468144
106POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19333975
107GF1_26923725_Chip-Seq_HPCs_Mouse1.18918399
108PU1_27457419_Chip-Seq_LIVER_Mouse1.18154194
109SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17764044
110GATA3_21867929_ChIP-Seq_CD8_Mouse1.17278566
111ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16322171
112GF1B_26923725_Chip-Seq_HPCs_Mouse1.16285445
113ER_23166858_ChIP-Seq_MCF-7_Human1.15948759
114MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15411819
115RUNX1_27457419_Chip-Seq_LIVER_Mouse1.15337934
116CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.14233394
117OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13582860
118GBX2_23144817_ChIP-Seq_PC3_Human1.13399854
119STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13254484
120NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12908852
121ZFX_18555785_Chip-Seq_ESCs_Mouse1.12906433
122CTCF_18555785_Chip-Seq_ESCs_Mouse1.12818727
123CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11763360
124UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11075761
125* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.10995903
126NMYC_18555785_Chip-Seq_ESCs_Mouse1.10383564
127NCOR_22424771_ChIP-Seq_293T_Human1.09492154
128ERG_20517297_ChIP-Seq_VCAP_Human1.09456667
129MYC_19829295_ChIP-Seq_ESCs_Human1.09325011
130FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08509483
131SOX2_21211035_ChIP-Seq_LN229_Gbm1.08286021
132CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08223449
133GATA3_21878914_ChIP-Seq_MCF-7_Human1.08124459
134* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06608904
135JUN_21703547_ChIP-Seq_K562_Human1.06561007
136GATA3_21867929_ChIP-Seq_TH1_Mouse1.06308307
137SMAD3_21741376_ChIP-Seq_ESCs_Human1.05647430
138LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.05454527
139SOX9_26525672_Chip-Seq_HEART_Mouse1.04978351
140AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04432987
141PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04145496
142HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.04100068
143SMAD1_18555785_Chip-Seq_ESCs_Mouse1.03747579
144PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03737151
145P300_19829295_ChIP-Seq_ESCs_Human1.02884317
146* TCF4_23295773_ChIP-Seq_U87_Human1.02528895
147RUNX1_26923725_Chip-Seq_HPCs_Mouse1.02308863
148SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.98685325
149SMAD3_21741376_ChIP-Seq_EPCs_Human0.98366997
150PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94475070
151* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93033837
152FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92666463

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.90510261
2MP0001929_abnormal_gametogenesis5.33702571
3MP0008877_abnormal_DNA_methylation4.16688819
4MP0003283_abnormal_digestive_organ3.74552889
5MP0002210_abnormal_sex_determination3.51634161
6MP0002822_catalepsy3.15849909
7MP0002161_abnormal_fertility/fecundity3.12963781
8MP0010234_abnormal_vibrissa_follicle3.12582454
9MP0002653_abnormal_ependyma_morphology3.05195326
10MP0002909_abnormal_adrenal_gland3.00111687
11MP0005670_abnormal_white_adipose2.80719689
12MP0001145_abnormal_male_reproductive2.78660164
13MP0003195_calcinosis2.66345862
14MP0002837_dystrophic_cardiac_calcinosis2.65110147
15MP0005379_endocrine/exocrine_gland_phen2.53652693
16MP0000653_abnormal_sex_gland2.51544180
17MP0010678_abnormal_skin_adnexa2.51361374
18MP0000383_abnormal_hair_follicle2.37626138
19MP0001944_abnormal_pancreas_morphology2.21150960
20MP0000013_abnormal_adipose_tissue2.16918412
21MP0002693_abnormal_pancreas_physiology2.16325184
22MP0003123_paternal_imprinting2.10158758
23MP0005410_abnormal_fertilization14.4829446
24MP0006072_abnormal_retinal_apoptosis1.98447144
25MP0010386_abnormal_urinary_bladder1.92623379
26MP0002160_abnormal_reproductive_system1.90555955
27MP0005220_abnormal_exocrine_pancreas1.83410540
28MP0009780_abnormal_chondrocyte_physiolo1.78580818
29MP0003122_maternal_imprinting1.77180151
30MP0001984_abnormal_olfaction1.70737362
31MP0004782_abnormal_surfactant_physiolog1.61048179
32MP0000427_abnormal_hair_cycle1.52305412
33MP0004043_abnormal_pH_regulation1.51166915
34MP0005646_abnormal_pituitary_gland1.50991893
35MP0005084_abnormal_gallbladder_morpholo1.47774634
36MP0003646_muscle_fatigue1.46334821
37MP0005377_hearing/vestibular/ear_phenot1.45545307
38MP0003878_abnormal_ear_physiology1.45545307
39MP0002078_abnormal_glucose_homeostasis1.45033460
40MP0008995_early_reproductive_senescence1.38895580
41MP0009046_muscle_twitch1.36396640
42MP0005332_abnormal_amino_acid1.34596593
43MP0005397_hematopoietic_system_phenotyp1.24719438
44MP0001545_abnormal_hematopoietic_system1.24719438
45MP0002282_abnormal_trachea_morphology1.23608415
46MP0002229_neurodegeneration1.22897831
47MP0004270_analgesia1.20860149
48MP0000003_abnormal_adipose_tissue1.20844158
49MP0005448_abnormal_energy_balance1.19817648
50MP0003172_abnormal_lysosome_physiology1.19724489
51MP0009697_abnormal_copulation1.19664959
52MP0002272_abnormal_nervous_system1.18753233
53MP0000631_abnormal_neuroendocrine_gland1.18013300
54MP0008058_abnormal_DNA_repair1.17707005
55MP0002102_abnormal_ear_morphology1.16529093
56MP0010329_abnormal_lipoprotein_level1.14876925
57MP0001501_abnormal_sleep_pattern1.14662250
58MP0003656_abnormal_erythrocyte_physiolo1.14213013
59MP0005389_reproductive_system_phenotype1.12590401
60MP0003953_abnormal_hormone_level1.09933803
61MP0005535_abnormal_body_temperature1.09611750
62MP0005623_abnormal_meninges_morphology1.08261197
63MP0003121_genomic_imprinting1.04725881
64MP0005647_abnormal_sex_gland1.03157637
65MP0003868_abnormal_feces_composition1.02692208
66MP0002132_abnormal_respiratory_system1.00235939
67MP0003950_abnormal_plasma_membrane0.98179825
68MP0004233_abnormal_muscle_weight0.96766519
69MP0001765_abnormal_ion_homeostasis0.96329936
70MP0008004_abnormal_stomach_pH0.95874157
71MP0002234_abnormal_pharynx_morphology0.95495981
72MP0002139_abnormal_hepatobiliary_system0.94975201
73MP0008057_abnormal_DNA_replication0.94713372
74MP0001756_abnormal_urination0.93544981
75MP0006036_abnormal_mitochondrial_physio0.88878028
76MP0005083_abnormal_biliary_tract0.88595995
77MP0002736_abnormal_nociception_after0.88374665
78MP0001177_atelectasis0.87449652
79MP0003115_abnormal_respiratory_system0.86568363
80MP0004808_abnormal_hematopoietic_stem0.84781783
81MP0002064_seizures0.83640179
82MP0004085_abnormal_heartbeat0.80836069
83MP0002735_abnormal_chemical_nociception0.78243838
84MP0010307_abnormal_tumor_latency0.78109433
85MP0001986_abnormal_taste_sensitivity0.77449446
86MP0004742_abnormal_vestibular_system0.77217665
87MP0002254_reproductive_system_inflammat0.75317940
88MP0002067_abnormal_sensory_capabilities0.74316789
89MP0005075_abnormal_melanosome_morpholog0.73415460
90MP0003183_abnormal_peptide_metabolism0.72388684
91MP0002184_abnormal_innervation0.71208441
92MP0002638_abnormal_pupillary_reflex0.70016114
93MP0002928_abnormal_bile_duct0.69897484
94MP0001324_abnormal_eye_pigmentation0.69836680
95MP0005551_abnormal_eye_electrophysiolog0.68161421
96MP0005310_abnormal_salivary_gland0.67693121
97MP0003136_yellow_coat_color0.67592541
98MP0003718_maternal_effect0.67501182
99MP0008875_abnormal_xenobiotic_pharmacok0.67395350
100MP0002876_abnormal_thyroid_physiology0.67135021
101MP0001485_abnormal_pinna_reflex0.66895855
102MP0002090_abnormal_vision0.66245717
103MP0002118_abnormal_lipid_homeostasis0.63916655
104MP0005174_abnormal_tail_pigmentation0.63266243
105MP0005253_abnormal_eye_physiology0.62536472
106MP0001968_abnormal_touch/_nociception0.60156052
107MP0002133_abnormal_respiratory_system0.59305848
108MP0005388_respiratory_system_phenotype0.59305848
109MP0001119_abnormal_female_reproductive0.58070420
110MP0000566_synostosis0.57520421
111MP0003011_delayed_dark_adaptation0.56983948
112MP0008007_abnormal_cellular_replicative0.55863977
113MP0003787_abnormal_imprinting0.54825612
114MP0003786_premature_aging0.51709900
115MP0004133_heterotaxia0.51177208
116MP0001293_anophthalmia0.50737724
117MP0005636_abnormal_mineral_homeostasis0.47650050
118MP0000534_abnormal_ureter_morphology0.46884065
119MP0002557_abnormal_social/conspecific_i0.45350595
120MP0002796_impaired_skin_barrier0.45036703
121MP0001963_abnormal_hearing_physiology0.44471533
122MP0003699_abnormal_female_reproductive0.44063865
123MP0001486_abnormal_startle_reflex0.43255005
124MP0001270_distended_abdomen0.43128275
125MP0004019_abnormal_vitamin_homeostasis0.42352762
126MP0008569_lethality_at_weaning0.41937068
127MP0003942_abnormal_urinary_system0.41895588
128MP0005503_abnormal_tendon_morphology0.40768039
129MP0010094_abnormal_chromosome_stability0.40723716
130MP0003943_abnormal_hepatobiliary_system0.39637793
131MP0005171_absent_coat_pigmentation0.39185242
132MP0000026_abnormal_inner_ear0.38381865
133MP0002572_abnormal_emotion/affect_behav0.37906706
134MP0005391_vision/eye_phenotype0.36753832
135MP0004134_abnormal_chest_morphology0.36629543
136MP0003879_abnormal_hair_cell0.35649665
137MP0002163_abnormal_gland_morphology0.35530471
138MP0000049_abnormal_middle_ear0.35273425
139MP0005645_abnormal_hypothalamus_physiol0.34392292
140MP0006292_abnormal_olfactory_placode0.34045044
141MP0003941_abnormal_skin_development0.33366559
142MP0001502_abnormal_circadian_rhythm0.32666148
143MP0000678_abnormal_parathyroid_gland0.32333956
144MP0009250_abnormal_appendicular_skeleto0.32276018
145MP0005423_abnormal_somatic_nervous0.32137580
146MP0009115_abnormal_fat_cell0.30995702
147MP0009745_abnormal_behavioral_response0.29293818
148MP0001188_hyperpigmentation0.29056059
149MP0000569_abnormal_digit_pigmentation0.28713222
150MP0005195_abnormal_posterior_eye0.28297837
151MP0000015_abnormal_ear_pigmentation0.27042965
152MP0003633_abnormal_nervous_system0.26886919
153MP0002277_abnormal_respiratory_mucosa0.25630933
154MP0001440_abnormal_grooming_behavior0.25146504
155MP0002152_abnormal_brain_morphology0.25122851
156MP0002127_abnormal_cardiovascular_syste0.24925299
157MP0002249_abnormal_larynx_morphology0.24405955

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.74123231
2Abnormal respiratory epithelium morphology (HP:0012253)9.74123231
3Abnormal ciliary motility (HP:0012262)8.86662353
4Rhinitis (HP:0012384)8.12596007
5Chronic bronchitis (HP:0004469)6.95722982
6Nasal polyposis (HP:0100582)5.88580280
7Infertility (HP:0000789)5.74337861
8Hypoglycemic seizures (HP:0002173)5.37113951
9Bronchiectasis (HP:0002110)5.10970285
10Hyperinsulinemic hypoglycemia (HP:0000825)4.85092654
11Abnormality of the nasal mucosa (HP:0000433)4.81243407
12Ketoacidosis (HP:0001993)4.66355070
13Hypoglycemic coma (HP:0001325)4.39435967
14Bronchitis (HP:0012387)4.02340359
15Nephronophthisis (HP:0000090)4.00815208
16Abnormality of the pancreatic islet cells (HP:0006476)3.99702822
17Abnormality of endocrine pancreas physiology (HP:0012093)3.99702822
18Symptomatic seizures (HP:0011145)3.91513091
19Medial flaring of the eyebrow (HP:0010747)3.72422124
20Hyperglycemia (HP:0003074)3.57431935
21Hypothermia (HP:0002045)3.45984133
22Tubulointerstitial nephritis (HP:0001970)3.38513060
23Insulin-resistant diabetes mellitus (HP:0000831)3.29495270
24Chronic sinusitis (HP:0011109)3.27374207
25Abnormality of the renal medulla (HP:0100957)3.21761029
26Ketosis (HP:0001946)3.07876982
27Large for gestational age (HP:0001520)3.05597098
28Abnormal pancreas size (HP:0012094)3.01490997
29EEG with generalized epileptiform discharges (HP:0011198)2.95659678
30Epileptiform EEG discharges (HP:0011182)2.95269962
31Recurrent otitis media (HP:0000403)2.93167144
32Recurrent sinusitis (HP:0011108)2.91598494
33Congenital primary aphakia (HP:0007707)2.88358241
34Gait imbalance (HP:0002141)2.87147979
35Late onset (HP:0003584)2.75111039
36Prominent metopic ridge (HP:0005487)2.73141407
37Male infertility (HP:0003251)2.71327747
38Unilateral renal agenesis (HP:0000122)2.71224179
39Hyperthyroidism (HP:0000836)2.70655113
40Nephrogenic diabetes insipidus (HP:0009806)2.70615563
41Pancreatic fibrosis (HP:0100732)2.69971721
42Abnormal spermatogenesis (HP:0008669)2.65270695
43Molar tooth sign on MRI (HP:0002419)2.61098206
44Abnormality of midbrain morphology (HP:0002418)2.61098206
45Supernumerary spleens (HP:0009799)2.57157062
46Menstrual irregularities (HP:0000858)2.56375058
47Hypsarrhythmia (HP:0002521)2.53527700
48True hermaphroditism (HP:0010459)2.49891809
49Furrowed tongue (HP:0000221)2.47641633
50Ventricular fibrillation (HP:0001663)2.44564328
51Pancreatic islet-cell hyperplasia (HP:0004510)2.43017980
52Tubulointerstitial abnormality (HP:0001969)2.38235093
53Aplasia/hypoplasia of the uterus (HP:0008684)2.38018776
54Abnormality of the metopic suture (HP:0005556)2.31775941
55Postaxial foot polydactyly (HP:0001830)2.26802109
56Poor coordination (HP:0002370)2.25390397
57Tubular atrophy (HP:0000092)2.25361114
58Metaphyseal dysplasia (HP:0100255)2.24104410
59Type I diabetes mellitus (HP:0100651)2.21525517
60Intestinal atresia (HP:0011100)2.21123395
61Hypomagnesemia (HP:0002917)2.20176510
62Methylmalonic acidemia (HP:0002912)2.17074786
63Genital tract atresia (HP:0001827)2.14117675
64Severe visual impairment (HP:0001141)2.13453093
65Vaginal atresia (HP:0000148)2.12695359
66Congenital hepatic fibrosis (HP:0002612)2.11623705
67Median cleft lip (HP:0000161)2.09985149
68Recurrent bronchitis (HP:0002837)2.06751944
69Cystic liver disease (HP:0006706)2.00989147
70Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.00187168
71Dynein arm defect of respiratory motile cilia (HP:0012255)13.2679617
72Absent/shortened dynein arms (HP:0200106)13.2679617
73Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.4036925
74Abnormal respiratory motile cilium physiology (HP:0012261)10.1511763
75Pancreatic cysts (HP:0001737)1.98763914
76Aplasia/Hypoplasia of the lens (HP:0008063)1.97023209
77Abnormality of vitamin B metabolism (HP:0004340)1.96139463
78Occipital encephalocele (HP:0002085)1.94308594
79Postaxial hand polydactyly (HP:0001162)1.94213746
80Sensory axonal neuropathy (HP:0003390)1.93445315
81Abnormality of lateral ventricle (HP:0030047)1.92477250
82Aplasia/Hypoplasia of the tongue (HP:0010295)1.91903109
83Homocystinuria (HP:0002156)1.91076330
84Abnormality of homocysteine metabolism (HP:0010919)1.91076330
85Tetany (HP:0001281)1.89541951
86Glycosuria (HP:0003076)1.87126247
87Abnormality of urine glucose concentration (HP:0011016)1.87126247
88Insulin resistance (HP:0000855)1.83897122
89Bell-shaped thorax (HP:0001591)1.82027375
90Decreased central vision (HP:0007663)1.81661524
91Chronic hepatic failure (HP:0100626)1.79303957
92Febrile seizures (HP:0002373)1.79223200
93Agitation (HP:0000713)1.78993664
94Progressive hearing impairment (HP:0001730)1.78770262
95Urethral obstruction (HP:0000796)1.78597223
96Progressive macrocephaly (HP:0004481)1.78501527
97Gaze-evoked nystagmus (HP:0000640)1.77665206
98Abnormal sex determination (HP:0012244)1.76865491
99Sex reversal (HP:0012245)1.76865491
100Impulsivity (HP:0100710)1.76160319
101Increased circulating renin level (HP:0000848)1.76109102
102Facial cleft (HP:0002006)1.74203981
103Hyperkalemia (HP:0002153)1.73758903
104Abnormality of the renal cortex (HP:0011035)1.73399414
105Hemiparesis (HP:0001269)1.73397817
106Tubulointerstitial fibrosis (HP:0005576)1.72997248
107Tachypnea (HP:0002789)1.71374586
108Absent eyebrow (HP:0002223)1.70427174
109Azoospermia (HP:0000027)1.69810741
110Neoplasm of the adrenal cortex (HP:0100641)1.68994154
111Thyroid carcinoma (HP:0002890)1.68768206
112Polyuria (HP:0000103)1.68403619
113Stage 5 chronic kidney disease (HP:0003774)1.68061908
114Abnormality of macular pigmentation (HP:0008002)1.67706337
115Proximal tubulopathy (HP:0000114)1.67081824
116Abnormality of the dental root (HP:0006486)1.65328596
117Taurodontia (HP:0000679)1.65328596
118Abnormality of permanent molar morphology (HP:0011071)1.65328596
119Renal dysplasia (HP:0000110)1.62755096
120Abnormality of dentin (HP:0010299)1.61712127
121Fibular hypoplasia (HP:0003038)1.58734355
122Gonadotropin excess (HP:0000837)1.58482429
123Abnormality of molar morphology (HP:0011070)1.58155335
124Abnormality of molar (HP:0011077)1.58155335
125Abnormality of the dental pulp (HP:0006479)1.55932926
126Oculomotor apraxia (HP:0000657)1.54439827
127Abnormal drinking behavior (HP:0030082)1.41091675
128Polydipsia (HP:0001959)1.41091675
129Preaxial hand polydactyly (HP:0001177)1.37335317
130Broad foot (HP:0001769)1.36954576
131Anencephaly (HP:0002323)1.34290817
132Abnormality of renal excretion (HP:0011036)1.33788313
133Abnormal biliary tract physiology (HP:0012439)1.30388988
134Bile duct proliferation (HP:0001408)1.30388988
135Aplasia/Hypoplasia of the tibia (HP:0005772)1.29939429
136Truncal obesity (HP:0001956)1.28405232
137Dyschromatopsia (HP:0007641)1.27286540
138Short ribs (HP:0000773)1.26924887
139Astigmatism (HP:0000483)1.26725595
140Retinitis pigmentosa (HP:0000510)1.25317840
141Sclerocornea (HP:0000647)1.22770326
142Specific learning disability (HP:0001328)1.22636449
143Male pseudohermaphroditism (HP:0000037)1.21443693
144Heterotopia (HP:0002282)1.20677710
145Microglossia (HP:0000171)1.19528769
146Impaired proprioception (HP:0010831)1.18713399
147Papillary thyroid carcinoma (HP:0002895)1.16263692
148Cone-rod dystrophy (HP:0000548)1.15557205
149Nephropathy (HP:0000112)1.15433974
150Sloping forehead (HP:0000340)1.15186441
151Aganglionic megacolon (HP:0002251)1.15079076
152Short tibia (HP:0005736)1.13713571
153Decreased testicular size (HP:0008734)1.12845173
154Absent frontal sinuses (HP:0002688)1.12370216
155Short thorax (HP:0010306)1.12129615
156Hyperphosphatemia (HP:0002905)1.11299800
157Hypoplasia of the capital femoral epiphysis (HP:0003090)1.10735498
158Dental crowding (HP:0000678)1.10633862
159Multicystic kidney dysplasia (HP:0000003)1.09313540

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.31185792
2PDK48.31185792
3FRK6.91266082
4MAP4K25.41652193
5PDK25.38630569
6TESK14.74012416
7PRKD34.31034894
8ICK2.67243027
9FGFR22.49504900
10PLK42.47720236
11NTRK32.43113147
12PNCK1.91585059
13INSRR1.90598902
14MAP3K21.90508739
15PTK2B1.87842503
16SIK31.69915484
17ACVR1B1.63305976
18FGFR31.55452370
19NEK21.54105310
20STK391.49188274
21LMTK21.43076995
22WNK41.40441833
23PHKG11.38934959
24PHKG21.38934959
25STK381.38537314
26IRAK11.20486157
27DYRK1B1.18221870
28STK38L1.17922337
29MAP3K41.10370665
30MAP3K91.09428288
31TAOK31.05417774
32HIPK21.02481687
33AKT31.01128193
34CASK1.00613109
35MAPK150.98112028
36MUSK0.96487994
37NLK0.89383176
38YES10.87709541
39BRD40.85454277
40TNIK0.85289619
41CCNB10.85123010
42PDK10.84937020
43NEK60.84485636
44BMPR20.83810665
45EPHA30.80999300
46STK160.80452534
47DYRK30.78306773
48PLK20.78216436
49WNK30.71409980
50PINK10.70409558
51TIE10.69560022
52SGK20.68395122
53STK30.64461321
54PRKAA20.62920020
55PLK30.62715097
56OXSR10.61008072
57SGK10.58932867
58CDK120.56817007
59DAPK20.54713271
60WNK10.53522986
61NUAK10.53249382
62PAK30.52713488
63TGFBR20.52287494
64GRK70.51892421
65TXK0.51238942
66MAP2K70.50669564
67CSNK1G20.49741441
68MAP2K60.49598040
69TYRO30.48948913
70RET0.46981006
71MAP3K120.46044551
72IRAK20.45740295
73ZAK0.44520043
74PRKCG0.44103553
75ERBB30.43914793
76TAF10.43683928
77CSNK1G10.42237745
78LATS10.41469173
79FER0.39244261
80NTRK20.38778635
81KSR20.37478842
82CHEK20.37289236
83RIPK10.37102362
84GRK10.37062559
85VRK10.35591714
86CSNK1G30.34806944
87CAMK2D0.34222645
88SGK2230.34116098
89SGK4940.34116098
90MAP3K70.33696399
91MKNK20.33171498
92RIPK40.33054003
93BCR0.32911068
94PRKACB0.30355444
95MAP3K10.29779280
96SGK30.28745610
97CHEK10.28720587
98ALK0.28030914
99BRSK20.27232546
100CSNK1E0.25693745
101PASK0.25685516
102EGFR0.24907628
103ATM0.24571260
104BMPR1B0.24270233
105PDPK10.23957437
106CAMK10.23707353
107TSSK60.23214459
108EIF2AK20.22988680
109WEE10.22867616
110ADRBK20.22511399
111STK40.22484017
112CDK30.22125456
113STK100.21940050
114PRKG10.21814701
115TRPM70.21126565
116MAPK130.21044227
117PRKCA0.20896854
118RPS6KA40.20337881
119TEC0.18714980
120GRK50.18349543
121ATR0.18219507
122RPS6KB10.18096093
123MARK30.17936412
124STK240.17718005
125BRAF0.16209856
126CAMK1G0.16195084
127PLK10.15152508
128SRPK10.14082020
129PRKAA10.13801190
130PAK10.13104824
131BRSK10.12205669
132MAP3K30.12193613
133TTK0.12149238
134CSNK2A10.11809967
135PRKCQ0.10854860
136CAMK2A0.09987427
137PRKCE0.09134413
138EIF2AK10.07805695
139PKN10.06150627
140MST40.04741792
141PRKACA0.04116479
142PRKCD0.03663057
143PRKG20.03372186
144GSK3B0.03236955
145SIK10.03138624
146EPHA40.02985309
147PIK3CG0.02734886

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.90384547
2Vitamin B6 metabolism_Homo sapiens_hsa007504.13443229
3Fatty acid biosynthesis_Homo sapiens_hsa000613.95319954
4Basal transcription factors_Homo sapiens_hsa030223.91173877
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.63261655
6Pyruvate metabolism_Homo sapiens_hsa006203.48189732
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.46819634
8Butanoate metabolism_Homo sapiens_hsa006503.13958607
9Protein export_Homo sapiens_hsa030602.74211348
10Propanoate metabolism_Homo sapiens_hsa006402.66882965
11Type II diabetes mellitus_Homo sapiens_hsa049302.65949173
12Glucagon signaling pathway_Homo sapiens_hsa049222.38837482
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.32689105
14Fanconi anemia pathway_Homo sapiens_hsa034602.23355590
15Linoleic acid metabolism_Homo sapiens_hsa005912.13512748
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.03682091
17Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.93747316
18Regulation of autophagy_Homo sapiens_hsa041401.86969279
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.76123211
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.74543850
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.72523460
22Mineral absorption_Homo sapiens_hsa049781.70894527
23PPAR signaling pathway_Homo sapiens_hsa033201.69844673
24Arachidonic acid metabolism_Homo sapiens_hsa005901.68746022
25Huntingtons disease_Homo sapiens_hsa050161.68359990
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.66343314
27Glycerolipid metabolism_Homo sapiens_hsa005611.65204304
28Carbohydrate digestion and absorption_Homo sapiens_hsa049731.58617782
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.58611457
30Fructose and mannose metabolism_Homo sapiens_hsa000511.48805932
31Selenocompound metabolism_Homo sapiens_hsa004501.43008183
32Purine metabolism_Homo sapiens_hsa002301.39499395
33Chemical carcinogenesis_Homo sapiens_hsa052041.38813114
34Oxidative phosphorylation_Homo sapiens_hsa001901.36231115
35Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.35765563
36Amphetamine addiction_Homo sapiens_hsa050311.34831012
37Collecting duct acid secretion_Homo sapiens_hsa049661.34724484
38Oocyte meiosis_Homo sapiens_hsa041141.32856679
39Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.32786376
40Type I diabetes mellitus_Homo sapiens_hsa049401.26635785
41Pentose phosphate pathway_Homo sapiens_hsa000301.22138899
42Ether lipid metabolism_Homo sapiens_hsa005651.19232620
43Glutathione metabolism_Homo sapiens_hsa004801.18953613
44Taste transduction_Homo sapiens_hsa047421.13159217
45beta-Alanine metabolism_Homo sapiens_hsa004101.12930008
46Glycerophospholipid metabolism_Homo sapiens_hsa005641.09525858
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09112099
48Tryptophan metabolism_Homo sapiens_hsa003801.05982195
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05490175
50Dorso-ventral axis formation_Homo sapiens_hsa043201.01799545
51Renin secretion_Homo sapiens_hsa049241.01155699
52mTOR signaling pathway_Homo sapiens_hsa041500.98744932
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98209605
54Fatty acid degradation_Homo sapiens_hsa000710.97034978
55Fatty acid elongation_Homo sapiens_hsa000620.97005691
56Nicotine addiction_Homo sapiens_hsa050330.95491878
57Calcium signaling pathway_Homo sapiens_hsa040200.95171289
58mRNA surveillance pathway_Homo sapiens_hsa030150.85815096
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84818715
60Antigen processing and presentation_Homo sapiens_hsa046120.81530145
61Insulin secretion_Homo sapiens_hsa049110.81115924
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.80136419
63Synaptic vesicle cycle_Homo sapiens_hsa047210.79461363
64Vibrio cholerae infection_Homo sapiens_hsa051100.78435435
65Fatty acid metabolism_Homo sapiens_hsa012120.77820672
66Carbon metabolism_Homo sapiens_hsa012000.77404562
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76667092
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76022898
69Phototransduction_Homo sapiens_hsa047440.75009134
70Sulfur metabolism_Homo sapiens_hsa009200.74647998
71Hedgehog signaling pathway_Homo sapiens_hsa043400.74329236
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74074980
73Legionellosis_Homo sapiens_hsa051340.73296389
74Autoimmune thyroid disease_Homo sapiens_hsa053200.71843585
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.68534442
76Long-term depression_Homo sapiens_hsa047300.68060755
77Serotonergic synapse_Homo sapiens_hsa047260.67245980
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67072748
79Circadian entrainment_Homo sapiens_hsa047130.66967072
80Cardiac muscle contraction_Homo sapiens_hsa042600.66916035
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63190031
82Nitrogen metabolism_Homo sapiens_hsa009100.61281184
83ABC transporters_Homo sapiens_hsa020100.61202524
84RNA degradation_Homo sapiens_hsa030180.59879204
85Pancreatic secretion_Homo sapiens_hsa049720.59865845
86Ovarian steroidogenesis_Homo sapiens_hsa049130.58599197
87Inositol phosphate metabolism_Homo sapiens_hsa005620.57100423
88Salivary secretion_Homo sapiens_hsa049700.56763156
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56435789
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.56191754
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53915379
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52864555
93Renin-angiotensin system_Homo sapiens_hsa046140.50324177
94Insulin resistance_Homo sapiens_hsa049310.49492044
95Retinol metabolism_Homo sapiens_hsa008300.48381025
96Protein digestion and absorption_Homo sapiens_hsa049740.48238682
97Caffeine metabolism_Homo sapiens_hsa002320.48014310
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47489816
99Morphine addiction_Homo sapiens_hsa050320.46359916
100Cocaine addiction_Homo sapiens_hsa050300.44637303
101Metabolic pathways_Homo sapiens_hsa011000.43916164
102Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42896880
103Thyroid hormone synthesis_Homo sapiens_hsa049180.42738659
104Rheumatoid arthritis_Homo sapiens_hsa053230.42737821
105Long-term potentiation_Homo sapiens_hsa047200.42671447
106Parkinsons disease_Homo sapiens_hsa050120.42296714
107AMPK signaling pathway_Homo sapiens_hsa041520.42071774
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41717076
109Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40994352
110Basal cell carcinoma_Homo sapiens_hsa052170.40860561
111Pyrimidine metabolism_Homo sapiens_hsa002400.40804564
112Estrogen signaling pathway_Homo sapiens_hsa049150.40554852
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39738026
114Circadian rhythm_Homo sapiens_hsa047100.38627256
115cAMP signaling pathway_Homo sapiens_hsa040240.38261002
116Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38107964
117Alzheimers disease_Homo sapiens_hsa050100.37269423
118Lysine degradation_Homo sapiens_hsa003100.36910303
119Measles_Homo sapiens_hsa051620.36517335
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.35887807
121RNA transport_Homo sapiens_hsa030130.35585263
122Dopaminergic synapse_Homo sapiens_hsa047280.35109397
123Prolactin signaling pathway_Homo sapiens_hsa049170.34936825
124Folate biosynthesis_Homo sapiens_hsa007900.34801738
125Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33860360
126GABAergic synapse_Homo sapiens_hsa047270.33444375
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31715171
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31539698
129Homologous recombination_Homo sapiens_hsa034400.31079877
130N-Glycan biosynthesis_Homo sapiens_hsa005100.30475596
131Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.30470890
132Wnt signaling pathway_Homo sapiens_hsa043100.29706377
133Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.29526481
134Glutamatergic synapse_Homo sapiens_hsa047240.29305968
135Gastric acid secretion_Homo sapiens_hsa049710.27848365
136Peroxisome_Homo sapiens_hsa041460.27237519
137Olfactory transduction_Homo sapiens_hsa047400.26960330
138Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.26542658
139Cell cycle_Homo sapiens_hsa041100.26048537
140Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25483083
141Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23815459
142Allograft rejection_Homo sapiens_hsa053300.22647265
143Sphingolipid metabolism_Homo sapiens_hsa006000.22569428
144Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.22075449

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