CCDC7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)7.06914473
2fusion of sperm to egg plasma membrane (GO:0007342)6.65535046
3establishment of protein localization to Golgi (GO:0072600)6.65113922
4acrosome reaction (GO:0007340)6.47249846
5protein targeting to Golgi (GO:0000042)6.46284785
6retrograde transport, vesicle recycling within Golgi (GO:0000301)6.18822201
7protein polyglutamylation (GO:0018095)5.85170870
8plasma membrane fusion (GO:0045026)4.90387286
9microtubule depolymerization (GO:0007019)4.79811969
10single strand break repair (GO:0000012)4.75918086
11protein localization to Golgi apparatus (GO:0034067)4.73300008
12multicellular organism reproduction (GO:0032504)4.71895192
13spermatid development (GO:0007286)4.42404386
14cilium or flagellum-dependent cell motility (GO:0001539)4.40058181
15cell wall macromolecule catabolic process (GO:0016998)4.32905257
16centriole replication (GO:0007099)4.28277693
17spermatid nucleus differentiation (GO:0007289)4.21393715
18regulation of cilium movement (GO:0003352)4.18034866
19microtubule severing (GO:0051013)4.17088164
20response to pheromone (GO:0019236)4.08936488
21calcium ion-dependent exocytosis (GO:0017156)4.01704877
22sperm capacitation (GO:0048240)3.89479249
23cell wall macromolecule metabolic process (GO:0044036)3.87927000
24cellular ketone body metabolic process (GO:0046950)3.84128438
25negative regulation of inclusion body assembly (GO:0090084)3.82989508
26microtubule polymerization or depolymerization (GO:0031109)3.77348595
27reproduction (GO:0000003)3.70479001
28phosphatidylethanolamine biosynthetic process (GO:0006646)3.70379406
29sperm-egg recognition (GO:0035036)3.69205835
30spermatogenesis (GO:0007283)3.63084542
31male gamete generation (GO:0048232)3.62213725
32phosphatidylethanolamine metabolic process (GO:0046337)3.60519095
33epithelial cilium movement (GO:0003351)3.59139329
34intra-Golgi vesicle-mediated transport (GO:0006891)3.58080983
35Golgi to endosome transport (GO:0006895)3.57752480
36regulation of meiosis I (GO:0060631)3.53748160
37positive regulation of Rab GTPase activity (GO:0032851)3.53528298
38regulation of Rab GTPase activity (GO:0032313)3.53528298
39RNA destabilization (GO:0050779)3.52660380
40axonemal dynein complex assembly (GO:0070286)3.50288991
41cilium movement (GO:0003341)3.47749085
42epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.47054138
43gamete generation (GO:0007276)3.40746287
44protein K11-linked deubiquitination (GO:0035871)3.39237996
45centriole assembly (GO:0098534)3.37728321
46piRNA metabolic process (GO:0034587)3.35431364
47ketone body metabolic process (GO:1902224)3.33046576
48male meiosis I (GO:0007141)3.32397407
49termination of G-protein coupled receptor signaling pathway (GO:0038032)3.26818806
50rRNA methylation (GO:0031167)3.23667204
51single fertilization (GO:0007338)3.17813334
52antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.17381315
53male meiosis (GO:0007140)3.14115350
54axoneme assembly (GO:0035082)3.11692778
55cell-cell recognition (GO:0009988)3.10275564
56DNA packaging (GO:0006323)3.09725332
57DNA methylation involved in gamete generation (GO:0043046)3.08432227
58microtubule nucleation (GO:0007020)3.06866847
59positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.04140596
60termination of signal transduction (GO:0023021)3.00397088
61histone mRNA catabolic process (GO:0071044)2.94939459
62dopamine transport (GO:0015872)2.93296931
63positive regulation of meiosis (GO:0045836)2.90852862
64motile cilium assembly (GO:0044458)2.90246326
65fertilization (GO:0009566)2.86010156
66germ cell development (GO:0007281)2.85864583
67cyclic nucleotide catabolic process (GO:0009214)2.84178666
68mast cell activation involved in immune response (GO:0002279)2.83694005
69mast cell degranulation (GO:0043303)2.83694005
70positive regulation of endothelial cell differentiation (GO:0045603)2.83263445
71multicellular organismal movement (GO:0050879)2.81225693
72musculoskeletal movement (GO:0050881)2.81225693
73positive regulation of granulocyte differentiation (GO:0030854)2.80254033
74seminiferous tubule development (GO:0072520)2.79983325
75interkinetic nuclear migration (GO:0022027)2.74435942
76cilium organization (GO:0044782)2.73049224
77meiosis I (GO:0007127)2.70670104
78cilium assembly (GO:0042384)2.70469158
79multicellular organismal reproductive process (GO:0048609)2.69917271
80cAMP catabolic process (GO:0006198)2.69724116
81regulation of microtubule-based movement (GO:0060632)2.68562574
82positive regulation of meiotic cell cycle (GO:0051446)2.67130774
83neural tube formation (GO:0001841)2.64947868
84peptidyl-threonine dephosphorylation (GO:0035970)2.64799176
85regulation of phosphoprotein phosphatase activity (GO:0043666)2.60554097
86binding of sperm to zona pellucida (GO:0007339)2.60308170
87phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.57213610
88photoreceptor cell maintenance (GO:0045494)2.56979849
89cellular process involved in reproduction in multicellular organism (GO:0022412)2.56085218
90negative regulation of response to food (GO:0032096)2.55821564
91negative regulation of appetite (GO:0032099)2.55821564
92synapsis (GO:0007129)2.51893232
93regulation of glucokinase activity (GO:0033131)2.50188036
94regulation of hexokinase activity (GO:1903299)2.50188036
95detection of light stimulus involved in visual perception (GO:0050908)2.49061317
96detection of light stimulus involved in sensory perception (GO:0050962)2.49061317
97protein K48-linked deubiquitination (GO:0071108)2.49037211
98protein K63-linked deubiquitination (GO:0070536)2.48052323
99negative regulation of G-protein coupled receptor protein signaling pathway (GO:0045744)2.47109739
100positive regulation of glycolytic process (GO:0045821)2.45167338

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.80992656
2GBX2_23144817_ChIP-Seq_PC3_Human3.13996213
3POU3F2_20337985_ChIP-ChIP_501MEL_Human2.71049723
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.52098457
5TAF15_26573619_Chip-Seq_HEK293_Human2.39389382
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.33004650
7FUS_26573619_Chip-Seq_HEK293_Human2.28765817
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.10415805
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08726939
10IGF1R_20145208_ChIP-Seq_DFB_Human2.06690565
11AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.05956810
12ER_23166858_ChIP-Seq_MCF-7_Human1.97981550
13P300_19829295_ChIP-Seq_ESCs_Human1.95756108
14SMAD4_21799915_ChIP-Seq_A2780_Human1.93343087
15FLI1_27457419_Chip-Seq_LIVER_Mouse1.90291845
16* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88051933
17IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.87914455
18CBP_20019798_ChIP-Seq_JUKART_Human1.87914455
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85379030
20* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79917720
21PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.78864649
22STAT3_23295773_ChIP-Seq_U87_Human1.78786028
23* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.77191402
24AR_25329375_ChIP-Seq_VCAP_Human1.74452834
25VDR_22108803_ChIP-Seq_LS180_Human1.73857653
26POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.70836682
27TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70836682
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.67719773
29TCF4_23295773_ChIP-Seq_U87_Human1.60728166
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56815507
31* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56748226
32RUNX_20019798_ChIP-Seq_JUKART_Human1.54414986
33EZH2_22144423_ChIP-Seq_EOC_Human1.50917239
34SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49997628
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48826407
36ZNF274_21170338_ChIP-Seq_K562_Hela1.48782419
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48560663
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.46143317
39ARNT_22903824_ChIP-Seq_MCF-7_Human1.44513911
40NANOG_18555785_Chip-Seq_ESCs_Mouse1.43779280
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.43639648
42TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43415620
43SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.42260767
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.38812816
45PRDM14_20953172_ChIP-Seq_ESCs_Human1.38061174
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36979806
47BCAT_22108803_ChIP-Seq_LS180_Human1.36210379
48STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.35378910
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.35339270
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33918163
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33716767
52* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33244537
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32642952
54EWS_26573619_Chip-Seq_HEK293_Human1.31621686
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.31377962
56SMAD4_21741376_ChIP-Seq_EPCs_Human1.29106940
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28885827
58TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.27092666
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27033282
60FLI1_21867929_ChIP-Seq_TH2_Mouse1.24988932
61NANOG_19829295_ChIP-Seq_ESCs_Human1.23593966
62SOX2_19829295_ChIP-Seq_ESCs_Human1.23593966
63LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23476820
64NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22761151
65E2F1_18555785_Chip-Seq_ESCs_Mouse1.22202536
66* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21639346
67RUNX2_22187159_ChIP-Seq_PCA_Human1.21376918
68AR_21572438_ChIP-Seq_LNCaP_Human1.20149064
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.19676503
70FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19381899
71P53_22387025_ChIP-Seq_ESCs_Mouse1.18412062
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17449877
73TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.15956700
74EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14319524
75TBL1_22424771_ChIP-Seq_293T_Human1.13661593
76* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13525623
77SCL_19346495_ChIP-Seq_HPC-7_Human1.12922181
78* CDX2_22108803_ChIP-Seq_LS180_Human1.12735963
79SMRT_27268052_Chip-Seq_Bcells_Human1.12198431
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11937139
81* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11362263
82TCF4_22108803_ChIP-Seq_LS180_Human1.10558150
83SALL4_22934838_ChIP-ChIP_CD34+_Human1.09920688
84TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09339361
85AHR_22903824_ChIP-Seq_MCF-7_Human1.09006407
86IRF8_22096565_ChIP-ChIP_GC-B_Human1.08687951
87SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06688595
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06409901
89KDM2B_26808549_Chip-Seq_REH_Human1.05812635
90TAL1_26923725_Chip-Seq_HPCs_Mouse1.04168006
91SOX2_21211035_ChIP-Seq_LN229_Gbm1.03868098
92STAT3_18555785_Chip-Seq_ESCs_Mouse1.03140220
93OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02419761
94CMYC_18555785_Chip-Seq_ESCs_Mouse1.02375333
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02322847
96FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02261952
97* NFYB_21822215_ChIP-Seq_K562_Human1.02204772
98PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00943799
99FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99987489
100FOXA1_25329375_ChIP-Seq_VCAP_Human0.99987489

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.26874409
2MP0000569_abnormal_digit_pigmentation4.50677926
3MP0008877_abnormal_DNA_methylation3.58499576
4MP0005464_abnormal_platelet_physiology2.72810803
5MP0003698_abnormal_male_reproductive2.54528765
6MP0003787_abnormal_imprinting2.33948276
7MP0001986_abnormal_taste_sensitivity2.33845202
8MP0001929_abnormal_gametogenesis2.28768884
9MP0005670_abnormal_white_adipose2.19927646
10MP0005379_endocrine/exocrine_gland_phen2.17822705
11MP0000015_abnormal_ear_pigmentation2.03769588
12MP0009780_abnormal_chondrocyte_physiolo2.01877005
13MP0005645_abnormal_hypothalamus_physiol1.98697524
14MP0005551_abnormal_eye_electrophysiolog1.77978895
15MP0008057_abnormal_DNA_replication1.69183869
16MP0005174_abnormal_tail_pigmentation1.67853417
17MP0005310_abnormal_salivary_gland1.64110553
18MP0003718_maternal_effect1.62872485
19MP0009697_abnormal_copulation1.57931700
20MP0001486_abnormal_startle_reflex1.56475549
21MP0002837_dystrophic_cardiac_calcinosis1.54712505
22MP0005646_abnormal_pituitary_gland1.53071956
23MP0001968_abnormal_touch/_nociception1.52752851
24MP0001984_abnormal_olfaction1.45515429
25MP0003646_muscle_fatigue1.41329837
26MP0005423_abnormal_somatic_nervous1.40630226
27MP0009046_muscle_twitch1.37947043
28MP0002163_abnormal_gland_morphology1.35593803
29MP0008872_abnormal_physiological_respon1.33963298
30MP0000013_abnormal_adipose_tissue1.33396687
31MP0003724_increased_susceptibility_to1.32682901
32MP0010386_abnormal_urinary_bladder1.31235526
33MP0000372_irregular_coat_pigmentation1.29781221
34MP0005253_abnormal_eye_physiology1.27961764
35MP0009745_abnormal_behavioral_response1.27421639
36MP0005084_abnormal_gallbladder_morpholo1.26806260
37MP0002693_abnormal_pancreas_physiology1.26171073
38MP0000427_abnormal_hair_cycle1.23429522
39MP0000230_abnormal_systemic_arterial1.23067675
40MP0003879_abnormal_hair_cell1.22797671
41MP0008004_abnormal_stomach_pH1.18377838
42MP0003045_fibrosis1.18374781
43MP0003633_abnormal_nervous_system1.17488583
44MP0001765_abnormal_ion_homeostasis1.17227003
45MP0002161_abnormal_fertility/fecundity1.15528161
46MP0001835_abnormal_antigen_presentation1.14558587
47MP0004142_abnormal_muscle_tone1.13301515
48MP0002272_abnormal_nervous_system1.12947830
49MP0002210_abnormal_sex_determination1.12815047
50MP0001905_abnormal_dopamine_level1.12580039
51MP0004484_altered_response_of1.11086134
52MP0005075_abnormal_melanosome_morpholog1.09896262
53MP0000383_abnormal_hair_follicle1.08809476
54MP0005671_abnormal_response_to1.08037158
55MP0002067_abnormal_sensory_capabilities1.04691957
56MP0000653_abnormal_sex_gland1.03350501
57MP0001501_abnormal_sleep_pattern1.02017469
58MP0004381_abnormal_hair_follicle1.01591136
59MP0004085_abnormal_heartbeat0.99350202
60MP0000465_gastrointestinal_hemorrhage0.98072585
61MP0002229_neurodegeneration0.97907866
62MP0003656_abnormal_erythrocyte_physiolo0.97609111
63MP0002928_abnormal_bile_duct0.97112349
64MP0004043_abnormal_pH_regulation0.97078236
65MP0004036_abnormal_muscle_relaxation0.95982297
66MP0005167_abnormal_blood-brain_barrier0.95954806
67MP0001145_abnormal_male_reproductive0.94382383
68MP0004084_abnormal_cardiac_muscle0.91974987
69MP0005377_hearing/vestibular/ear_phenot0.91198399
70MP0003878_abnormal_ear_physiology0.91198399
71MP0003631_nervous_system_phenotype0.90973341
72MP0010329_abnormal_lipoprotein_level0.89875686
73MP0003763_abnormal_thymus_physiology0.86561264
74MP0005535_abnormal_body_temperature0.84909855
75MP0003252_abnormal_bile_duct0.84731158
76MP0002735_abnormal_chemical_nociception0.84457052
77MP0006072_abnormal_retinal_apoptosis0.83149850
78MP0005395_other_phenotype0.80455438
79MP0002876_abnormal_thyroid_physiology0.79858312
80MP0002132_abnormal_respiratory_system0.79600282
81MP0004215_abnormal_myocardial_fiber0.79321137
82MP0005397_hematopoietic_system_phenotyp0.77087252
83MP0001545_abnormal_hematopoietic_system0.77087252
84MP0002138_abnormal_hepatobiliary_system0.76947170
85MP0002095_abnormal_skin_pigmentation0.75121372
86MP0005636_abnormal_mineral_homeostasis0.73477825
87MP0002557_abnormal_social/conspecific_i0.73474945
88MP0002064_seizures0.72403613
89MP0005266_abnormal_metabolism0.72057516
90MP0002127_abnormal_cardiovascular_syste0.70516877
91MP0003183_abnormal_peptide_metabolism0.70081892
92MP0002653_abnormal_ependyma_morphology0.69650243
93MP0001800_abnormal_humoral_immune0.69530829
94MP0002736_abnormal_nociception_after0.69262806
95MP0003195_calcinosis0.69186767
96MP0002572_abnormal_emotion/affect_behav0.68774157
97MP0001963_abnormal_hearing_physiology0.68670278
98MP0008569_lethality_at_weaning0.68506945
99MP0010678_abnormal_skin_adnexa0.68356761
100MP0004924_abnormal_behavior0.68223428

Predicted human phenotypes

RankGene SetZ-score
1Chronic hepatic failure (HP:0100626)4.00884831
2Tubulointerstitial nephritis (HP:0001970)3.90614101
3Dynein arm defect of respiratory motile cilia (HP:0012255)3.89829929
4Absent/shortened dynein arms (HP:0200106)3.89829929
5Prolonged bleeding time (HP:0003010)3.68886262
6Severe visual impairment (HP:0001141)3.55388819
7Abnormal ciliary motility (HP:0012262)3.55041964
8Hyperventilation (HP:0002883)3.17363397
9Polydipsia (HP:0001959)3.16715581
10Abnormal drinking behavior (HP:0030082)3.16715581
11Nephronophthisis (HP:0000090)3.13776780
12Attenuation of retinal blood vessels (HP:0007843)3.10989736
13Abnormal respiratory motile cilium physiology (HP:0012261)3.09449614
14Gaze-evoked nystagmus (HP:0000640)3.07613246
15Insulin-resistant diabetes mellitus (HP:0000831)3.04843372
16Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.04517975
17Abnormality of the renal cortex (HP:0011035)3.01353471
18Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.97170273
19Abnormality of the renal medulla (HP:0100957)2.91793494
20Medial flaring of the eyebrow (HP:0010747)2.88824339
21Progressive cerebellar ataxia (HP:0002073)2.87906923
22Postural instability (HP:0002172)2.83734903
23Hyperkalemia (HP:0002153)2.83523373
24Gingival bleeding (HP:0000225)2.79993285
25Male infertility (HP:0003251)2.78105910
26Abnormal respiratory motile cilium morphology (HP:0005938)2.73651578
27Abnormal respiratory epithelium morphology (HP:0012253)2.73651578
28Metaphyseal dysplasia (HP:0100255)2.64951398
29Abnormal rod and cone electroretinograms (HP:0008323)2.64759257
30Febrile seizures (HP:0002373)2.63974413
31Bony spicule pigmentary retinopathy (HP:0007737)2.63289847
32Petechiae (HP:0000967)2.57830596
33Pancreatic fibrosis (HP:0100732)2.57513690
34Truncal obesity (HP:0001956)2.55915437
35Increased mean platelet volume (HP:0011877)2.54749341
36Pancreatic cysts (HP:0001737)2.53712841
37Volvulus (HP:0002580)2.52981649
38Abnormality of macular pigmentation (HP:0008002)2.49854052
39Menorrhagia (HP:0000132)2.48639962
40Hypoplastic ischia (HP:0003175)2.46162735
41Thyroiditis (HP:0100646)2.41674873
42Menstrual irregularities (HP:0000858)2.36929454
43Rhinitis (HP:0012384)2.36344776
44Abnormality of the ischium (HP:0003174)2.34026630
45Polyuria (HP:0000103)2.31003920
46Abnormal platelet volume (HP:0011876)2.29441830
47Epistaxis (HP:0000421)2.29327157
48Ketoacidosis (HP:0001993)2.29203486
49Fair hair (HP:0002286)2.25899569
50Congenital primary aphakia (HP:0007707)2.25583192
51Renal Fanconi syndrome (HP:0001994)2.23855330
52Infertility (HP:0000789)2.23672459
53Portal hypertension (HP:0001409)2.20694187
54Gait imbalance (HP:0002141)2.20119931
55Widely spaced teeth (HP:0000687)2.19342052
56Resting tremor (HP:0002322)2.18473535
57Papillary thyroid carcinoma (HP:0002895)2.17753763
58Hypoplasia of the thymus (HP:0000778)2.17069514
59Abnormal spermatogenesis (HP:0008669)2.12326505
60Hyperlipoproteinemia (HP:0010980)2.11478999
61Abnormal urine output (HP:0012590)2.10026168
62Tubulointerstitial abnormality (HP:0001969)2.06836824
63Abnormality of the hepatic vasculature (HP:0006707)2.00824333
64Poor coordination (HP:0002370)1.99836518
65Abnormality of midbrain morphology (HP:0002418)1.98690628
66Molar tooth sign on MRI (HP:0002419)1.98690628
67Abnormality of potassium homeostasis (HP:0011042)1.97548525
68Abnormality of renal resorption (HP:0011038)1.96930882
69Decreased central vision (HP:0007663)1.96012567
70Tubular atrophy (HP:0000092)1.94000673
71Enlarged epiphyses (HP:0010580)1.93761980
72Generalized aminoaciduria (HP:0002909)1.93411409
73Pancreatic islet-cell hyperplasia (HP:0004510)1.92395906
74Cone-rod dystrophy (HP:0000548)1.91986086
75Abnormality of renal excretion (HP:0011036)1.91933560
76Genital tract atresia (HP:0001827)1.88858172
77Nephrogenic diabetes insipidus (HP:0009806)1.88609951
78Poikilocytosis (HP:0004447)1.88191266
79Dyschromatopsia (HP:0007641)1.87741284
80Stage 5 chronic kidney disease (HP:0003774)1.87509838
81Aplasia/Hypoplasia of the earlobes (HP:0009906)1.86440684
82Congenital sensorineural hearing impairment (HP:0008527)1.86286199
83True hermaphroditism (HP:0010459)1.85932265
84Renal cortical cysts (HP:0000803)1.85478213
85Stomatitis (HP:0010280)1.85005816
86Stomach cancer (HP:0012126)1.84441543
87Oligodactyly (hands) (HP:0001180)1.82612421
88Generalized hypopigmentation of hair (HP:0011358)1.82136601
89Pigmentary retinal degeneration (HP:0001146)1.80316764
90Acanthocytosis (HP:0001927)1.79059292
91Bronchiectasis (HP:0002110)1.78875741
92Hypoglycemic seizures (HP:0002173)1.78441591
93Amelogenesis imperfecta (HP:0000705)1.78389763
94Genetic anticipation (HP:0003743)1.76455361
95Neoplasm of the tracheobronchial system (HP:0100552)1.74753296
96Congenital stationary night blindness (HP:0007642)1.72799199
97Congenital hepatic fibrosis (HP:0002612)1.71504543
98Intestinal atresia (HP:0011100)1.71224396
99Bell-shaped thorax (HP:0001591)1.70623298
100Vaginal atresia (HP:0000148)1.69020624

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.13479469
2MAP4K23.19322912
3TXK2.96477878
4PLK42.81566185
5PNCK2.65584879
6INSRR2.51138666
7PIK3CG2.42444142
8PTK2B2.25901902
9PLK22.22932618
10TEC2.03770486
11AKT31.93679701
12STK38L1.80002126
13PINK11.74637507
14WNK31.68026222
15TAOK31.64577119
16MST41.64382457
17STK381.62247562
18STK391.61145434
19CAMK1G1.50675980
20NUAK11.46855705
21RIPK41.40868842
22CCNB11.39769117
23TRPM71.37650294
24BMPR1B1.34702606
25MAP3K41.33295108
26ACVR1B1.31519068
27SGK21.31407079
28MAPK131.29000130
29TNIK1.25080299
30BMPR21.22301103
31NTRK31.18390516
32ADRBK21.13990691
33BLK1.11861574
34CAMKK21.11544487
35NLK1.10447687
36PDK11.08278942
37WNK11.08056319
38SYK1.05149973
39PAK31.01276587
40BTK0.96609503
41FGFR20.96535981
42GRK60.95042450
43WNK40.93582015
44CSF1R0.91181808
45TNK20.89594690
46ZAK0.88194605
47OXSR10.85540889
48ITK0.85335704
49IKBKE0.80974484
50OBSCN0.80124720
51CASK0.75071620
52MAP3K20.74199096
53MAP3K120.74034272
54GRK10.71758393
55SGK4940.70883240
56SGK2230.70883240
57FGFR30.70427499
58IKBKB0.70321962
59PRKG10.69787719
60GRK50.69770319
61SGK30.68233159
62MARK30.67028145
63SGK10.64530249
64STK30.63291536
65BRD40.62175917
66MYLK0.62001175
67FGR0.61641982
68PDPK10.61632703
69JAK10.58749949
70PRKCE0.57221406
71CAMK10.57149373
72NEK60.55267377
73PRKCQ0.54985392
74FLT30.52692885
75LYN0.51292982
76DDR20.49777925
77PHKG20.48758352
78PHKG10.48758352
79ERBB20.48740768
80PRKG20.48263720
81FER0.46368656
82KIT0.45383085
83CDK30.44902388
84MAP2K70.43744292
85BMX0.43071340
86CAMK40.41041253
87JAK30.38527171
88PRKCB0.38496460
89PRKAA20.37732145
90ADRBK10.36299504
91TLK10.36254016
92STK110.36026971
93CAMK2A0.34691878
94STK40.34579538
95LCK0.33037812
96NEK90.32905919
97LMTK20.32848834
98DAPK20.32836060
99YES10.31962878
100HCK0.31592300

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000612.99122039
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.83753315
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.50878667
4Olfactory transduction_Homo sapiens_hsa047402.49007389
5Platelet activation_Homo sapiens_hsa046112.20421661
6Phototransduction_Homo sapiens_hsa047442.08788857
7Dorso-ventral axis formation_Homo sapiens_hsa043202.05049782
8Circadian entrainment_Homo sapiens_hsa047131.89720861
9Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.86382535
10Butanoate metabolism_Homo sapiens_hsa006501.83854462
11Renin secretion_Homo sapiens_hsa049241.83311588
12Morphine addiction_Homo sapiens_hsa050321.72458869
13Circadian rhythm_Homo sapiens_hsa047101.61014892
14ABC transporters_Homo sapiens_hsa020101.60958636
15Nitrogen metabolism_Homo sapiens_hsa009101.57906068
16Nicotine addiction_Homo sapiens_hsa050331.53244415
17Taste transduction_Homo sapiens_hsa047421.52771901
18Insulin secretion_Homo sapiens_hsa049111.50885286
19Salivary secretion_Homo sapiens_hsa049701.46116576
20Phosphatidylinositol signaling system_Homo sapiens_hsa040701.45949185
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.43596877
22Glycerophospholipid metabolism_Homo sapiens_hsa005641.40018703
23Type II diabetes mellitus_Homo sapiens_hsa049301.39293261
24Type I diabetes mellitus_Homo sapiens_hsa049401.37857303
25Serotonergic synapse_Homo sapiens_hsa047261.33068936
26Regulation of autophagy_Homo sapiens_hsa041401.28624547
27Long-term depression_Homo sapiens_hsa047301.26677071
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.24478814
29Vascular smooth muscle contraction_Homo sapiens_hsa042701.23691813
30Calcium signaling pathway_Homo sapiens_hsa040201.18927329
31Glutamatergic synapse_Homo sapiens_hsa047241.18153950
32Primary immunodeficiency_Homo sapiens_hsa053401.14843786
33GABAergic synapse_Homo sapiens_hsa047271.09293553
34Inositol phosphate metabolism_Homo sapiens_hsa005621.06701890
35Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06193039
36Alcoholism_Homo sapiens_hsa050341.04205444
37cAMP signaling pathway_Homo sapiens_hsa040240.99943756
38B cell receptor signaling pathway_Homo sapiens_hsa046620.99735065
39T cell receptor signaling pathway_Homo sapiens_hsa046600.98028073
40Systemic lupus erythematosus_Homo sapiens_hsa053220.97907697
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94750361
42Pancreatic secretion_Homo sapiens_hsa049720.94201917
43Linoleic acid metabolism_Homo sapiens_hsa005910.94152983
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.92840886
45Amphetamine addiction_Homo sapiens_hsa050310.92027789
46Primary bile acid biosynthesis_Homo sapiens_hsa001200.91964605
47Oxytocin signaling pathway_Homo sapiens_hsa049210.90975586
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90248660
49Cholinergic synapse_Homo sapiens_hsa047250.89471876
50Graft-versus-host disease_Homo sapiens_hsa053320.89069629
51Glycerolipid metabolism_Homo sapiens_hsa005610.86729237
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86073574
53Long-term potentiation_Homo sapiens_hsa047200.84311324
54Chemokine signaling pathway_Homo sapiens_hsa040620.79066641
55Gap junction_Homo sapiens_hsa045400.78055305
56Dopaminergic synapse_Homo sapiens_hsa047280.77727886
57Gastric acid secretion_Homo sapiens_hsa049710.77288946
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73249926
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72876207
60Jak-STAT signaling pathway_Homo sapiens_hsa046300.72521119
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.67243880
62Fatty acid degradation_Homo sapiens_hsa000710.65991484
63Caffeine metabolism_Homo sapiens_hsa002320.65886705
64Arachidonic acid metabolism_Homo sapiens_hsa005900.65751709
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65259809
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64754116
67Ether lipid metabolism_Homo sapiens_hsa005650.63858908
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62218045
69Basal transcription factors_Homo sapiens_hsa030220.61285026
70Fanconi anemia pathway_Homo sapiens_hsa034600.61258185
71Hematopoietic cell lineage_Homo sapiens_hsa046400.61072314
72Homologous recombination_Homo sapiens_hsa034400.59673544
73Peroxisome_Homo sapiens_hsa041460.58956227
74mTOR signaling pathway_Homo sapiens_hsa041500.58445787
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57722438
76FoxO signaling pathway_Homo sapiens_hsa040680.56871640
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.56415909
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56121486
79Oocyte meiosis_Homo sapiens_hsa041140.52105489
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51206002
81Collecting duct acid secretion_Homo sapiens_hsa049660.50864155
82Fatty acid metabolism_Homo sapiens_hsa012120.50176932
83Allograft rejection_Homo sapiens_hsa053300.48423474
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.48374472
85Autoimmune thyroid disease_Homo sapiens_hsa053200.47039458
86Sphingolipid metabolism_Homo sapiens_hsa006000.46753757
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46456414
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46051638
89Retinol metabolism_Homo sapiens_hsa008300.45395037
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45255282
91beta-Alanine metabolism_Homo sapiens_hsa004100.44539494
92Purine metabolism_Homo sapiens_hsa002300.44096126
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43815032
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41482874
95Glucagon signaling pathway_Homo sapiens_hsa049220.41202277
96Choline metabolism in cancer_Homo sapiens_hsa052310.40642613
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38404703
98Prolactin signaling pathway_Homo sapiens_hsa049170.36893371
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36846088
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.36711625

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