CCDC70

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.94575619
2axonemal dynein complex assembly (GO:0070286)9.65955764
3spermatid development (GO:0007286)9.65195583
4cilium or flagellum-dependent cell motility (GO:0001539)9.57151685
5epithelial cilium movement (GO:0003351)9.56083010
6motile cilium assembly (GO:0044458)9.40568142
7regulation of cilium movement (GO:0003352)8.41034527
8cilium movement (GO:0003341)7.78148607
9single fertilization (GO:0007338)7.72532783
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.33541711
11sperm capacitation (GO:0048240)7.11953919
12male meiosis (GO:0007140)7.03422879
13synaptonemal complex organization (GO:0070193)6.90776138
14piRNA metabolic process (GO:0034587)6.83518592
15negative regulation of inclusion body assembly (GO:0090084)6.81402459
16synaptonemal complex assembly (GO:0007130)6.77343305
17spermatogenesis (GO:0007283)6.64324172
18male gamete generation (GO:0048232)6.61901009
19microtubule depolymerization (GO:0007019)6.56177358
20fertilization (GO:0009566)6.43589719
21organic cation transport (GO:0015695)6.42869441
22gamete generation (GO:0007276)6.08789388
23regulation of inclusion body assembly (GO:0090083)5.71521975
24calcium ion-dependent exocytosis (GO:0017156)5.64462022
25cellular process involved in reproduction in multicellular organism (GO:0022412)5.39103282
26germ cell development (GO:0007281)5.35112617
27spermatid nucleus differentiation (GO:0007289)5.26482505
28cell recognition (GO:0008037)5.19524694
29ventricular system development (GO:0021591)5.09738544
30glycerol ether metabolic process (GO:0006662)5.04449223
31chromosome condensation (GO:0030261)5.00033509
32regulation of microtubule-based movement (GO:0060632)4.95252378
33multicellular organismal reproductive process (GO:0048609)4.79022814
34DNA packaging (GO:0006323)4.71105240
35ether metabolic process (GO:0018904)4.66413925
36chromosome organization involved in meiosis (GO:0070192)4.65367193
37male meiosis I (GO:0007141)4.62452897
38microtubule severing (GO:0051013)4.60563043
39DNA methylation involved in gamete generation (GO:0043046)4.44992840
40seminiferous tubule development (GO:0072520)4.44973347
41meiotic nuclear division (GO:0007126)4.15169737
42chaperone-mediated protein complex assembly (GO:0051131)4.14539945
43left/right pattern formation (GO:0060972)3.98295103
44sexual reproduction (GO:0019953)3.92582596
45multicellular organismal development (GO:0007275)3.86314431
46single strand break repair (GO:0000012)3.83884450
47meiosis I (GO:0007127)3.68112808
48sequestering of actin monomers (GO:0042989)3.57857541
49monoubiquitinated protein deubiquitination (GO:0035520)3.48455895
50genitalia morphogenesis (GO:0035112)3.46514338
51protein polyglutamylation (GO:0018095)3.45135019
52microtubule polymerization or depolymerization (GO:0031109)3.40266719
53protein K11-linked deubiquitination (GO:0035871)3.34974774
54regulation of spindle checkpoint (GO:0090231)3.28256915
55meiotic cell cycle (GO:0051321)3.16997175
56protein localization to cilium (GO:0061512)3.16000081
57amino-acid betaine transport (GO:0015838)3.15166741
58carnitine transport (GO:0015879)3.15166741
59protein refolding (GO:0042026)3.11515273
60glycolytic process (GO:0006096)3.09304368
61polyol catabolic process (GO:0046174)3.06989423
62nucleus organization (GO:0006997)3.02142072
63nucleoside diphosphate phosphorylation (GO:0006165)3.01095659
64carnitine transmembrane transport (GO:1902603)2.98107098
65alditol metabolic process (GO:0019400)2.96761553
66positive regulation of macrophage activation (GO:0043032)2.94284792
67mitotic sister chromatid cohesion (GO:0007064)2.90581187
68GTP biosynthetic process (GO:0006183)2.88092405
69synapsis (GO:0007129)2.82009930
70interferon-gamma secretion (GO:0072643)2.80279690
71cilium organization (GO:0044782)2.79499685
72microtubule-based movement (GO:0007018)2.72108069
73cellular component assembly involved in morphogenesis (GO:0010927)2.71647619
74lactate metabolic process (GO:0006089)2.71265385
75cilium morphogenesis (GO:0060271)2.70568201
76cilium assembly (GO:0042384)2.68695581
77centriole assembly (GO:0098534)2.68635436
78intraciliary transport (GO:0042073)2.68220809
79meiotic cell cycle process (GO:1903046)2.67533079
80axoneme assembly (GO:0035082)2.63534286
81RNA localization (GO:0006403)2.61402967
82UTP biosynthetic process (GO:0006228)2.56563128
83regulation of cilium assembly (GO:1902017)2.56115082
84RNA destabilization (GO:0050779)2.52396872
85glycerol metabolic process (GO:0006071)2.51146468
86negative regulation of organelle assembly (GO:1902116)2.50964827
87polyamine biosynthetic process (GO:0006596)2.50138234
88gene silencing by RNA (GO:0031047)2.44289165
89chromatin silencing (GO:0006342)2.40222497
90fusion of sperm to egg plasma membrane (GO:0007342)14.3825877
91cell wall macromolecule metabolic process (GO:0044036)14.1095884
92cell wall macromolecule catabolic process (GO:0016998)14.1095884
93sperm motility (GO:0030317)13.7424664
94acrosome assembly (GO:0001675)12.2832049
95acrosome reaction (GO:0007340)12.0499135
96sperm-egg recognition (GO:0035036)11.9181415
97multicellular organism reproduction (GO:0032504)11.6657362
98plasma membrane fusion (GO:0045026)10.9646223
99cell-cell recognition (GO:0009988)10.6707520
100binding of sperm to zona pellucida (GO:0007339)10.6053359

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.42040791
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.18480003
3EZH2_22144423_ChIP-Seq_EOC_Human3.84661976
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.35155731
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.05226341
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.93963253
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.50579861
8VDR_22108803_ChIP-Seq_LS180_Human2.40584025
9CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.19207678
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.13738984
11ZNF274_21170338_ChIP-Seq_K562_Hela2.12696808
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.09552671
13EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.04315634
14GATA1_26923725_Chip-Seq_HPCs_Mouse2.01283524
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93154902
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88725101
17* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.82133769
18PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81934895
19TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.81472378
20ELK4_26923725_Chip-Seq_MESODERM_Mouse1.76708283
21MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.70220829
22FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66800222
23* STAT1_17558387_ChIP-Seq_HELA_Human1.66622870
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.65653871
25GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.63270634
26RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.60157744
27SOX2_22085726_ChIP-Seq_NPCs_Mouse1.59661850
28KAP1_22055183_ChIP-Seq_ESCs_Mouse1.58315371
29GATA3_21867929_ChIP-Seq_CD8_Mouse1.57006336
30WDR5_24793694_ChIP-Seq_LNCAP_Human1.56885630
31TAL1_26923725_Chip-Seq_HPCs_Mouse1.52227154
32* KDM2B_26808549_Chip-Seq_REH_Human1.49595870
33IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43395420
34CBP_20019798_ChIP-Seq_JUKART_Human1.43395420
35ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.40660693
36LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.39512317
37FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.33280013
38FLI1_21867929_ChIP-Seq_TH2_Mouse1.32909524
39NFE2_27457419_Chip-Seq_LIVER_Mouse1.32451835
40GATA3_21867929_ChIP-Seq_TH1_Mouse1.31712693
41PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.31663351
42P53_21459846_ChIP-Seq_SAOS-2_Human1.30336068
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30089646
44TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29760573
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28539367
46REST_21632747_ChIP-Seq_MESCs_Mouse1.27819407
47GF1_26923725_Chip-Seq_HPCs_Mouse1.25449126
48SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.25092410
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24814832
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22585679
51TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19227888
52CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17633127
53CRX_20693478_ChIP-Seq_RETINA_Mouse1.17154090
54PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16999002
55TAF15_26573619_Chip-Seq_HEK293_Human1.16804973
56NANOG_18555785_Chip-Seq_ESCs_Mouse1.14446029
57SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.14399079
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14087134
59RAD21_21589869_ChIP-Seq_MESCs_Mouse1.13717552
60CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11623747
61RUNX1_26923725_Chip-Seq_HPCs_Mouse1.11263716
62SPI1_26923725_Chip-Seq_HPCs_Mouse1.11199802
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09669620
64TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09669620
65ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09276936
66CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09224801
67PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08813254
68SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06771397
69OCT4_18555785_Chip-Seq_ESCs_Mouse1.05852864
70P53_22387025_ChIP-Seq_ESCs_Mouse1.03170116
71ESET_19884257_ChIP-Seq_ESCs_Mouse1.03121339
72ERG_20517297_ChIP-Seq_VCAP_Human1.02091605
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01351239
74RXRA_24833708_ChIP-Seq_LIVER_Mouse1.00955372
75CMYC_18555785_Chip-Seq_ESCs_Mouse1.00637247
76NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00626062
77RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00153449
78RNF2_27304074_Chip-Seq_NSC_Mouse1.00107508
79RARA_24833708_ChIP-Seq_LIVER_Mouse1.00071530
80MYC_27129775_Chip-Seq_CORNEA_Mouse0.99210717
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98597428
82PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98560956
83GATA1_19941827_ChIP-Seq_MEL86_Mouse0.98327042
84LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97991907
85OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96688283
86KLF4_18555785_Chip-Seq_ESCs_Mouse0.96303472
87P300_18555785_Chip-Seq_ESCs_Mouse0.96233471
88EZH2_27294783_Chip-Seq_NPCs_Mouse0.95110922
89JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.94596309
90* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.94086638
91ESRRB_18555785_Chip-Seq_ESCs_Mouse0.93209977
92SOX9_26525672_Chip-Seq_HEART_Mouse0.92989786
93GF1B_26923725_Chip-Seq_HPCs_Mouse0.92276769
94YY1_22570637_ChIP-Seq_MALME-3M_Human0.91629425
95TET1_21451524_ChIP-Seq_MESCs_Mouse0.91417303
96FLI1_21867929_ChIP-Seq_CD8_Mouse0.91117830
97SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91062591
98KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.90677437
99EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.90333578
100NFYB_21822215_ChIP-Seq_K562_Human0.89888978

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.08451679
2MP0001929_abnormal_gametogenesis5.54519339
3MP0008877_abnormal_DNA_methylation4.14636443
4MP0002210_abnormal_sex_determination3.37445764
5MP0002161_abnormal_fertility/fecundity3.30387051
6MP0001145_abnormal_male_reproductive2.87089446
7MP0005670_abnormal_white_adipose2.86826208
8MP0000653_abnormal_sex_gland2.49567282
9MP0002653_abnormal_ependyma_morphology2.47291246
10MP0005410_abnormal_fertilization16.5533116
11MP0004233_abnormal_muscle_weight1.61010731
12MP0002160_abnormal_reproductive_system1.58334421
13MP0005623_abnormal_meninges_morphology1.48285940
14MP0003646_muscle_fatigue1.46269929
15MP0002282_abnormal_trachea_morphology1.17682222
16MP0001765_abnormal_ion_homeostasis1.15880370
17MP0001984_abnormal_olfaction1.14387986
18MP0002234_abnormal_pharynx_morphology1.00192167
19MP0009046_muscle_twitch0.96989898
20MP0005647_abnormal_sex_gland0.93280781
21MP0008058_abnormal_DNA_repair0.86257580
22MP0008995_early_reproductive_senescence0.79226359
23MP0005389_reproductive_system_phenotype0.78878123
24MP0003011_delayed_dark_adaptation0.68199387
25MP0003115_abnormal_respiratory_system0.67342152
26MP0005636_abnormal_mineral_homeostasis0.63360059
27MP0003878_abnormal_ear_physiology0.54794137
28MP0005377_hearing/vestibular/ear_phenot0.54794137
29MP0005666_abnormal_adipose_tissue0.54788767
30MP0004036_abnormal_muscle_relaxation0.53183264
31MP0002102_abnormal_ear_morphology0.51418282
32MP0002269_muscular_atrophy0.50673159
33MP0001324_abnormal_eye_pigmentation0.50558663
34MP0002928_abnormal_bile_duct0.49526822
35MP0010094_abnormal_chromosome_stability0.48257524
36MP0003699_abnormal_female_reproductive0.47687355
37MP0003329_amyloid_beta_deposits0.47275795
38MP0001764_abnormal_homeostasis0.46657053
39MP0000358_abnormal_cell_content/0.44319859
40MP0005551_abnormal_eye_electrophysiolog0.42777291
41MP0003950_abnormal_plasma_membrane0.41954159
42MP0002736_abnormal_nociception_after0.40734742
43MP0006036_abnormal_mitochondrial_physio0.40606963
44MP0001293_anophthalmia0.40550210
45MP0005253_abnormal_eye_physiology0.40439192
46MP0001545_abnormal_hematopoietic_system0.36275130
47MP0005397_hematopoietic_system_phenotyp0.36275130
48MP0009115_abnormal_fat_cell0.35226611
49MP0000569_abnormal_digit_pigmentation0.33918229
50MP0000534_abnormal_ureter_morphology0.33281528
51MP0002971_abnormal_brown_adipose0.31501933
52MP0003633_abnormal_nervous_system0.31441558
53MP0009278_abnormal_bone_marrow0.30706624
54MP0002139_abnormal_hepatobiliary_system0.30157393
55MP0004133_heterotaxia0.29692943
56MP0005391_vision/eye_phenotype0.28619523
57MP0001119_abnormal_female_reproductive0.28581736
58MP0003786_premature_aging0.28576685
59MP0008057_abnormal_DNA_replication0.27169906
60MP0004019_abnormal_vitamin_homeostasis0.26275343
61MP0004811_abnormal_neuron_physiology0.26213602
62MP0003942_abnormal_urinary_system0.25234961
63MP0001730_embryonic_growth_arrest0.24641850
64MP0003111_abnormal_nucleus_morphology0.24418444
65MP0001968_abnormal_touch/_nociception0.23514888
66MP0000604_amyloidosis0.23377737
67MP0003861_abnormal_nervous_system0.23065421
68MP0003631_nervous_system_phenotype0.22351954
69MP0002152_abnormal_brain_morphology0.21545760
70MP0010307_abnormal_tumor_latency0.21519215
71MP0003879_abnormal_hair_cell0.21202162
72MP0006035_abnormal_mitochondrial_morpho0.21059442
73MP0002169_no_abnormal_phenotype0.20117795
74MP0002873_normal_phenotype0.19890380
75MP0003948_abnormal_gas_homeostasis0.19656532
76MP0008875_abnormal_xenobiotic_pharmacok0.18033924
77MP0008961_abnormal_basal_metabolism0.16579996
78MP0004742_abnormal_vestibular_system0.15665093
79MP0002295_abnormal_pulmonary_circulatio0.15469437
80MP0008007_abnormal_cellular_replicative0.15247155
81MP0004043_abnormal_pH_regulation0.14887243
82MP0000751_myopathy0.14841381
83MP0005319_abnormal_enzyme/_coenzyme0.14754235
84MP0004145_abnormal_muscle_electrophysio0.14544336
85MP0005365_abnormal_bile_salt0.14387330
86MP0004084_abnormal_cardiac_muscle0.13775487
87MP0000313_abnormal_cell_death0.13688452
88MP0002229_neurodegeneration0.13620441
89MP0005535_abnormal_body_temperature0.13598947
90MP0001661_extended_life_span0.13485267
91MP0004808_abnormal_hematopoietic_stem0.13304547
92MP0005375_adipose_tissue_phenotype0.13153952
93MP0005195_abnormal_posterior_eye0.13153690
94MP0004270_analgesia0.12887139
95MP0002084_abnormal_developmental_patter0.12817852
96MP0000001_mammalian_phenotype0.12792782
97MP0001727_abnormal_embryo_implantation0.12776435
98MP0002092_abnormal_eye_morphology0.12059845
99MP0002118_abnormal_lipid_homeostasis0.11682093
100MP0008569_lethality_at_weaning0.11420983

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.47582958
2Abnormal respiratory epithelium morphology (HP:0012253)9.35706146
3Abnormal respiratory motile cilium morphology (HP:0005938)9.35706146
4Abnormal ciliary motility (HP:0012262)7.64399429
5Rhinitis (HP:0012384)7.55250582
6Chronic bronchitis (HP:0004469)7.37255811
7Infertility (HP:0000789)6.77181266
8Nasal polyposis (HP:0100582)6.41234307
9Abnormality of the nasal mucosa (HP:0000433)5.27857806
10Male infertility (HP:0003251)4.73317040
11Bronchitis (HP:0012387)4.56121613
12Bronchiectasis (HP:0002110)4.41822060
13Nephronophthisis (HP:0000090)4.01375492
14Abnormal spermatogenesis (HP:0008669)3.71349913
15Recurrent sinusitis (HP:0011108)3.50989386
16Recurrent otitis media (HP:0000403)3.24494041
17Abnormality of the renal medulla (HP:0100957)3.01328296
18Medial flaring of the eyebrow (HP:0010747)2.79631311
19Tubulointerstitial nephritis (HP:0001970)2.69255430
20Recurrent bronchitis (HP:0002837)2.68698815
21Abnormality of midbrain morphology (HP:0002418)2.59855524
22Molar tooth sign on MRI (HP:0002419)2.59855524
23Tubular atrophy (HP:0000092)2.54332135
24Impulsivity (HP:0100710)2.52351815
25Azoospermia (HP:0000027)2.42534331
26Tubulointerstitial abnormality (HP:0001969)2.34689024
27Gonadotropin excess (HP:0000837)2.18682165
28Abnormal gallbladder physiology (HP:0012438)2.16525278
29Cholecystitis (HP:0001082)2.16525278
30Dyschromatopsia (HP:0007641)2.01544976
31Dynein arm defect of respiratory motile cilia (HP:0012255)13.5642111
32Absent/shortened dynein arms (HP:0200106)13.5642111
33Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1649015
34Tubulointerstitial fibrosis (HP:0005576)1.92700670
35Decreased central vision (HP:0007663)1.85781246
36Spastic tetraparesis (HP:0001285)1.79909705
37Choroideremia (HP:0001139)1.75160718
38Postaxial foot polydactyly (HP:0001830)1.74080781
39Abnormal drinking behavior (HP:0030082)1.73325976
40Polydipsia (HP:0001959)1.73325976
41Congenital primary aphakia (HP:0007707)1.72255203
42Gait imbalance (HP:0002141)1.72108683
43Stage 5 chronic kidney disease (HP:0003774)1.71911371
44Congenital hepatic fibrosis (HP:0002612)1.67963831
45Heterotopia (HP:0002282)1.66470078
46Aplasia/Hypoplasia of the lens (HP:0008063)1.65354812
47Abnormality of renal excretion (HP:0011036)1.62077190
48Abnormality of the renal cortex (HP:0011035)1.61730754
49Hypoplasia of the capital femoral epiphysis (HP:0003090)1.59417004
50Chronic sinusitis (HP:0011109)1.58671410
51Hemorrhage of the eye (HP:0011885)1.51807297
52Abnormal biliary tract physiology (HP:0012439)1.51026778
53Bile duct proliferation (HP:0001408)1.51026778
54Postaxial hand polydactyly (HP:0001162)1.49777166
55Oculomotor apraxia (HP:0000657)1.48634572
56Short ribs (HP:0000773)1.48610242
57Asymmetric septal hypertrophy (HP:0001670)1.47331029
58Nephrogenic diabetes insipidus (HP:0009806)1.45545705
59Renal dysplasia (HP:0000110)1.43776659
60Congenital malformation of the right heart (HP:0011723)1.42583077
61Double outlet right ventricle (HP:0001719)1.42583077
62Abnormality of permanent molar morphology (HP:0011071)1.42362763
63Abnormality of the dental root (HP:0006486)1.42362763
64Taurodontia (HP:0000679)1.42362763
65Fibular hypoplasia (HP:0003038)1.42148863
66Facial cleft (HP:0002006)1.39996745
67Decreased electroretinogram (ERG) amplitude (HP:0000654)1.38561430
68Bell-shaped thorax (HP:0001591)1.38312759
69Abnormality of the lower motor neuron (HP:0002366)1.37270981
70Bundle branch block (HP:0011710)1.37198610
71Neurofibrillary tangles (HP:0002185)1.37188171
72Easy fatigability (HP:0003388)1.36887040
73Abnormality of saccadic eye movements (HP:0000570)1.36322422
74Vaginal atresia (HP:0000148)1.33731163
75Genital tract atresia (HP:0001827)1.33144846
76Abnormal urine output (HP:0012590)1.32211687
77Abnormality of the dental pulp (HP:0006479)1.31907047
78Abnormality of molar (HP:0011077)1.31729314
79Abnormality of molar morphology (HP:0011070)1.31729314
80Cerebellar dysplasia (HP:0007033)1.31191659
81Abnormality of dentin (HP:0010299)1.30748252
82Cystic liver disease (HP:0006706)1.30081409
83Abnormality of the neuromuscular junction (HP:0003398)1.28893875
84Fatigable weakness (HP:0003473)1.28893875
85Poor coordination (HP:0002370)1.28037930
86Pancreatic fibrosis (HP:0100732)1.27988087
87Deformed sella turcica (HP:0002681)1.26283536
88Sensory axonal neuropathy (HP:0003390)1.25040147
89Microglossia (HP:0000171)1.24998860
90Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.24944327
91Absent epiphyses (HP:0010577)1.24944327
92Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.23312991
93Exercise-induced myalgia (HP:0003738)1.22050309
94Abnormality of ocular smooth pursuit (HP:0000617)1.21663999
95Amyotrophic lateral sclerosis (HP:0007354)1.20925397
96Absent frontal sinuses (HP:0002688)1.19499341
97Aplasia/Hypoplasia of the tongue (HP:0010295)1.17798961
98Constricted visual fields (HP:0001133)1.17347289
99Supernumerary spleens (HP:0009799)1.16402046
100Hemiparesis (HP:0001269)1.15032737

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.30251186
2PDK38.30251186
3TESK16.12229466
4PDK25.37462187
5PRKD35.02111051
6ICK4.37528997
7PTK2B2.31241868
8WNK42.18924192
9STK392.11077125
10PNCK1.83475293
11STK381.77720402
12NEK21.54104962
13DYRK1B1.48406016
14PDK11.22486958
15TYRO30.92490319
16IRAK10.83863068
17DYRK30.83679231
18MAPK150.80292033
19WNK10.80096237
20PDPK10.75746603
21TESK20.72395266
22PASK0.68008591
23CCNB10.66684911
24RIPK40.65480958
25LMTK20.64270597
26CHEK20.64063196
27STK30.61035844
28MAP2K60.60733724
29TTK0.58217182
30EEF2K0.55881470
31CAMK1G0.51409268
32PINK10.48993630
33STK38L0.46721224
34PLK40.45883451
35IRAK20.41577861
36MUSK0.41221641
37CHEK10.39986342
38PAK10.39489017
39NTRK20.35789103
40PRKCG0.34265639
41BRSK20.30681822
42WEE10.29338578
43MAP3K100.28521725
44PAK20.27723274
45ATM0.27693914
46CDK120.25178418
47MAPKAPK50.23288842
48MARK20.23227944
49ATR0.23061724
50MTOR0.22821719
51NEK60.21905419
52CAMKK10.20123839
53PAK40.18291269
54PRKAA10.18001897
55PRKCZ0.15688009
56CDC70.14552645
57BRSK10.14524236
58CDK150.14447309
59RPS6KB10.13750357
60PRKCQ0.13679169
61PLK10.13434955
62PRKG20.12769084
63PKN10.11865619
64CDK180.11760796
65MARK30.10603438
66CDK11A0.10477179
67BRAF0.10000393
68CSNK2A10.07507563
69RPS6KA10.07255322
70CDK140.07187411
71RIPK10.06663535
72PRKG10.06171607
73CSNK1D0.05996294
74GSK3B0.05885858
75STK100.05333505
76CSF1R0.05000501
77PRKACG0.04553749
78YES10.04288598
79CDK60.03805798
80CAMK2A0.03735687
81STK110.03150958
82CSNK2A20.03065259
83PRKCD0.02451394
84CDK20.02388361
85EGFR0.02255480
86CDK10.01964758
87ZAP700.01958746
88PDGFRB0.01894028
89PRKCB0.01397278
90MAPK80.01390984
91PRKCA0.00808213
92PRKACB-0.0302546
93PRKACA-0.0248267
94PRKDC-0.0220606
95MAP3K5-0.0214185
96MAP3K4-0.0192721
97AURKA-0.0157293
98WNK3-0.0154311
99CDK4-0.0141521
100PIM1-0.0136309

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.51832705
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.51686343
3Vitamin B6 metabolism_Homo sapiens_hsa007503.84130280
4Pyruvate metabolism_Homo sapiens_hsa006203.59758614
5Propanoate metabolism_Homo sapiens_hsa006402.96498719
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.92037062
7Linoleic acid metabolism_Homo sapiens_hsa005912.83435658
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.62438728
9Glucagon signaling pathway_Homo sapiens_hsa049222.58800293
10Basal transcription factors_Homo sapiens_hsa030222.39482657
11Carbohydrate digestion and absorption_Homo sapiens_hsa049732.24422679
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.09246953
13Selenocompound metabolism_Homo sapiens_hsa004502.08615638
14Glycerolipid metabolism_Homo sapiens_hsa005611.99112962
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.98306488
16Pentose phosphate pathway_Homo sapiens_hsa000301.97439746
17PPAR signaling pathway_Homo sapiens_hsa033201.91798785
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.83500800
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.68265437
20Oocyte meiosis_Homo sapiens_hsa041141.65310372
21Glycerophospholipid metabolism_Homo sapiens_hsa005641.58622108
22Fructose and mannose metabolism_Homo sapiens_hsa000511.53985394
23Mineral absorption_Homo sapiens_hsa049781.50349799
24Amphetamine addiction_Homo sapiens_hsa050311.47725631
25Carbon metabolism_Homo sapiens_hsa012001.47442428
26Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.44648643
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.40867193
28Cardiac muscle contraction_Homo sapiens_hsa042601.39931772
29Fat digestion and absorption_Homo sapiens_hsa049751.39322431
30Fatty acid degradation_Homo sapiens_hsa000711.39061668
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.38317008
32Fatty acid metabolism_Homo sapiens_hsa012121.37539096
33Ether lipid metabolism_Homo sapiens_hsa005651.30998672
34Dorso-ventral axis formation_Homo sapiens_hsa043201.30410820
35Fanconi anemia pathway_Homo sapiens_hsa034601.27706873
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.26348977
37Huntingtons disease_Homo sapiens_hsa050161.14579576
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10595131
39Renin secretion_Homo sapiens_hsa049241.09090074
40Purine metabolism_Homo sapiens_hsa002301.00868138
41Antigen processing and presentation_Homo sapiens_hsa046121.00659098
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00506140
43Glutathione metabolism_Homo sapiens_hsa004800.98275161
44Biosynthesis of amino acids_Homo sapiens_hsa012300.97633858
45Collecting duct acid secretion_Homo sapiens_hsa049660.93997777
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93526637
47mRNA surveillance pathway_Homo sapiens_hsa030150.92567326
48Insulin secretion_Homo sapiens_hsa049110.80751570
49RNA transport_Homo sapiens_hsa030130.80028895
50Chemical carcinogenesis_Homo sapiens_hsa052040.79967437
51Renin-angiotensin system_Homo sapiens_hsa046140.76951345
52Hedgehog signaling pathway_Homo sapiens_hsa043400.76927443
53Adipocytokine signaling pathway_Homo sapiens_hsa049200.75436180
54Bile secretion_Homo sapiens_hsa049760.72302943
55Arachidonic acid metabolism_Homo sapiens_hsa005900.72085159
56Long-term potentiation_Homo sapiens_hsa047200.71528775
57Thyroid hormone synthesis_Homo sapiens_hsa049180.70784623
58Estrogen signaling pathway_Homo sapiens_hsa049150.68224536
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66888665
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58331856
61Systemic lupus erythematosus_Homo sapiens_hsa053220.53502435
62Legionellosis_Homo sapiens_hsa051340.53185155
63Calcium signaling pathway_Homo sapiens_hsa040200.53116774
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.52046042
65Pancreatic secretion_Homo sapiens_hsa049720.51235857
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50177181
67Protein digestion and absorption_Homo sapiens_hsa049740.49931224
68Synaptic vesicle cycle_Homo sapiens_hsa047210.49105122
69ABC transporters_Homo sapiens_hsa020100.46573808
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46403248
71Salivary secretion_Homo sapiens_hsa049700.46056713
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44549684
73Inositol phosphate metabolism_Homo sapiens_hsa005620.44060431
74Metabolic pathways_Homo sapiens_hsa011000.42152924
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41860825
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40352613
77Endocytosis_Homo sapiens_hsa041440.39990541
78Gastric acid secretion_Homo sapiens_hsa049710.39384795
79AMPK signaling pathway_Homo sapiens_hsa041520.38783641
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.37920598
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37312191
82Sulfur metabolism_Homo sapiens_hsa009200.36217920
83Taste transduction_Homo sapiens_hsa047420.35750317
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35534166
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33085083
86N-Glycan biosynthesis_Homo sapiens_hsa005100.33044633
87VEGF signaling pathway_Homo sapiens_hsa043700.31207680
88cAMP signaling pathway_Homo sapiens_hsa040240.29788264
89Circadian entrainment_Homo sapiens_hsa047130.24292229
90Pyrimidine metabolism_Homo sapiens_hsa002400.22292049
91Alcoholism_Homo sapiens_hsa050340.20476697
92Cocaine addiction_Homo sapiens_hsa050300.19207906
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.16940288
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.14476204
95B cell receptor signaling pathway_Homo sapiens_hsa046620.09813229
96Salmonella infection_Homo sapiens_hsa051320.07530269
97Wnt signaling pathway_Homo sapiens_hsa043100.07065007
98HIF-1 signaling pathway_Homo sapiens_hsa040660.05250441
99Glutamatergic synapse_Homo sapiens_hsa047240.02522014
100Viral carcinogenesis_Homo sapiens_hsa052030.02010632

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