CCDC73

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1meiosis I (GO:0007127)9.98599085
2DNA synthesis involved in DNA repair (GO:0000731)9.95122729
3meiotic nuclear division (GO:0007126)9.06324298
4regulation of meiosis I (GO:0060631)8.29114165
5proline biosynthetic process (GO:0006561)7.91765292
6meiotic cell cycle process (GO:1903046)7.63890988
7replication fork processing (GO:0031297)6.89625278
8transcription from mitochondrial promoter (GO:0006390)6.68010254
9sister chromatid cohesion (GO:0007062)6.41528281
10histone H3-K9 demethylation (GO:0033169)6.28589699
11DNA deamination (GO:0045006)6.10629184
12proline metabolic process (GO:0006560)6.08243851
13maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.89442707
14reciprocal meiotic recombination (GO:0007131)5.78089884
15reciprocal DNA recombination (GO:0035825)5.78089884
16gene silencing by RNA (GO:0031047)5.77075834
17embryonic process involved in female pregnancy (GO:0060136)5.67071798
18positive regulation of protein homooligomerization (GO:0032464)5.65936769
19oxidative demethylation (GO:0070989)5.56538295
20poly(A)+ mRNA export from nucleus (GO:0016973)5.50283787
21regulation of histone H3-K9 methylation (GO:0051570)5.39461393
22meiotic cell cycle (GO:0051321)5.18779415
23negative regulation of neurotransmitter secretion (GO:0046929)5.09863165
24female gamete generation (GO:0007292)4.99398301
25histone H3-K36 demethylation (GO:0070544)4.86872094
26positive regulation of catecholamine secretion (GO:0033605)4.81153750
27viral mRNA export from host cell nucleus (GO:0046784)4.80884381
28regulation of protein homooligomerization (GO:0032462)4.75475404
29epithelial cilium movement (GO:0003351)4.70147975
30mitochondrial DNA metabolic process (GO:0032042)4.68401099
31regulation of integrin activation (GO:0033623)4.59810270
32epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.59077680
33DNA strand renaturation (GO:0000733)4.55542717
34establishment of apical/basal cell polarity (GO:0035089)4.55026818
35somatic hypermutation of immunoglobulin genes (GO:0016446)4.53073717
36somatic diversification of immune receptors via somatic mutation (GO:0002566)4.53073717
37positive regulation of amino acid transport (GO:0051957)4.46334242
38establishment of protein localization to mitochondrial membrane (GO:0090151)4.43353278
39negative regulation of gene silencing (GO:0060969)4.42297882
40negative regulation of amino acid transport (GO:0051956)4.34890592
41maturation of 5.8S rRNA (GO:0000460)4.28656697
42DNA alkylation (GO:0006305)4.26295772
43DNA methylation (GO:0006306)4.26295772
44cellular response to ATP (GO:0071318)4.20886087
45regulation of meiotic cell cycle (GO:0051445)4.16963410
46DNA methylation involved in gamete generation (GO:0043046)4.11297993
47meiotic chromosome segregation (GO:0045132)4.07489563
48positive regulation of meiosis (GO:0045836)4.04295155
49phospholipid scrambling (GO:0017121)4.03550712
50regulation of transcription from RNA polymerase I promoter (GO:0006356)4.03517227
51regulation of cilium movement (GO:0003352)4.03500490
52regulation of DNA endoreduplication (GO:0032875)4.01474735
53establishment of monopolar cell polarity (GO:0061162)4.01151119
54establishment or maintenance of monopolar cell polarity (GO:0061339)4.01151119
55negative regulation of JAK-STAT cascade (GO:0046426)3.94265946
56negative regulation of appetite (GO:0032099)3.92453544
57negative regulation of response to food (GO:0032096)3.92453544
58negative regulation of cell cycle arrest (GO:0071157)3.87804976
59regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.87202263
60acrosome assembly (GO:0001675)3.83687610
61regulation of double-strand break repair via homologous recombination (GO:0010569)3.83489125
62DNA integration (GO:0015074)3.83485554
63attachment of spindle microtubules to kinetochore (GO:0008608)3.83022197
64kinetochore assembly (GO:0051382)3.79613677
65cellular response to zinc ion (GO:0071294)3.77891105
66positive regulation of DNA repair (GO:0045739)3.77527941
67protein localization to chromosome (GO:0034502)3.76620525
68positive regulation of meiotic cell cycle (GO:0051446)3.76570481
69cilium movement (GO:0003341)3.75726351
70negative regulation of heart rate (GO:0010459)3.74287542
71piRNA metabolic process (GO:0034587)3.72839915
72interkinetic nuclear migration (GO:0022027)3.72657386
73DNA double-strand break processing (GO:0000729)3.67365646
74resolution of meiotic recombination intermediates (GO:0000712)3.66782502
75negative regulation of neurotransmitter transport (GO:0051589)3.65819132
76telomere maintenance via semi-conservative replication (GO:0032201)3.62634456
77positive regulation of dendritic spine morphogenesis (GO:0061003)3.62039745
78termination of RNA polymerase II transcription (GO:0006369)3.61574772
79DNA ligation (GO:0006266)3.58900729
80double-strand break repair via nonhomologous end joining (GO:0006303)3.57371391
81non-recombinational repair (GO:0000726)3.57371391
82positive regulation of mitotic sister chromatid separation (GO:1901970)3.54185455
83positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.54185455
84positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.54185455
85DNA biosynthetic process (GO:0071897)3.52333066
86mitotic chromosome condensation (GO:0007076)3.49795357
87mRNA cleavage (GO:0006379)3.48478837
88reproductive system development (GO:0061458)3.47764643
89base-excision repair, AP site formation (GO:0006285)3.46639728
90base-excision repair (GO:0006284)3.46468535
91regulation of double-strand break repair (GO:2000779)3.42565104
92chromosome organization (GO:0051276)3.37235357
93protein neddylation (GO:0045116)3.36730030
94nucleotide-excision repair, DNA gap filling (GO:0006297)3.35718487
95mitotic G1 DNA damage checkpoint (GO:0031571)3.34922959
96negative regulation of Ras GTPase activity (GO:0034261)3.34757172
97DNA replication checkpoint (GO:0000076)3.34667531
98histone H4-K12 acetylation (GO:0043983)3.32878223
99positive regulation of developmental pigmentation (GO:0048087)3.32632448
100positive regulation of circadian rhythm (GO:0042753)3.32436536
101cullin deneddylation (GO:0010388)3.32397161
102pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.32173302
103regulation of cAMP-dependent protein kinase activity (GO:2000479)3.32133873
104face development (GO:0060324)3.31416758
105gene silencing (GO:0016458)3.29925779
106regulation of glutamate secretion (GO:0014048)3.27789438
107serotonin receptor signaling pathway (GO:0007210)3.27551865
108histone exchange (GO:0043486)3.24944097
109negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)3.24747192
110negative regulation of protein oligomerization (GO:0032460)3.24309947
111fertilization (GO:0009566)3.24293013
112positive regulation of response to oxidative stress (GO:1902884)3.23169410
113positive regulation of cellular response to oxidative stress (GO:1900409)3.23169410
114centriole replication (GO:0007099)3.22983029
115axonemal dynein complex assembly (GO:0070286)3.22524331
116regulation of chromatin silencing (GO:0031935)3.22385612
117single strand break repair (GO:0000012)3.20789514
118mRNA polyadenylation (GO:0006378)3.19670076
119embryonic placenta development (GO:0001892)3.19606324
120DNA methylation or demethylation (GO:0044728)3.19045801
121glutamine family amino acid biosynthetic process (GO:0009084)3.18891725
122spermatid development (GO:0007286)3.18287885
123genitalia morphogenesis (GO:0035112)3.17228020
124proteasome assembly (GO:0043248)3.16724206
125convergent extension (GO:0060026)3.16335137
126regulation of meiosis (GO:0040020)3.15410526
127auditory receptor cell stereocilium organization (GO:0060088)3.14770871
128regulation of spindle checkpoint (GO:0090231)3.14591960
129kinetochore organization (GO:0051383)3.13653690
130formation of translation preinitiation complex (GO:0001731)3.13532626
131regulation of sister chromatid cohesion (GO:0007063)3.12306744
132regulation of respiratory system process (GO:0044065)3.12150409
133histone arginine methylation (GO:0034969)3.10954621
134mitochondrial fusion (GO:0008053)3.09054397
135telomere maintenance via recombination (GO:0000722)3.08447330
136G1 DNA damage checkpoint (GO:0044783)3.08089695
137negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.07025920
138mitotic cell cycle arrest (GO:0071850)3.06430722
139heart field specification (GO:0003128)3.06424088
140secondary heart field specification (GO:0003139)3.06424088
141oogenesis (GO:0048477)3.04736296
142positive regulation of protein oligomerization (GO:0032461)3.04504488
143mitotic sister chromatid segregation (GO:0000070)3.03308560
144regulation of protein oligomerization (GO:0032459)3.02757168
145histone H2A acetylation (GO:0043968)3.00874619
146protein deneddylation (GO:0000338)2.98626486
147embryonic camera-type eye development (GO:0031076)2.97142847
148mitochondrial DNA replication (GO:0006264)2.97031022
149histone H4-K16 acetylation (GO:0043984)2.94343521
150sex differentiation (GO:0007548)2.94006409
151regulation of DNA repair (GO:0006282)2.92978904
152nuclear division (GO:0000280)2.91951021
153DNA topological change (GO:0006265)2.91170835
154synaptic vesicle endocytosis (GO:0048488)2.90799695
155mitotic G1/S transition checkpoint (GO:0044819)2.90280093
156glial cell migration (GO:0008347)2.89689736
157histone lysine demethylation (GO:0070076)2.89417865
158RNA polyadenylation (GO:0043631)2.89308151
159positive regulation of histone H3-K4 methylation (GO:0051571)2.89038555
160germ cell development (GO:0007281)2.86822593
161histone demethylation (GO:0016577)2.85616725
162positive regulation of histone methylation (GO:0031062)2.85292998
163positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.83206828
164mitotic spindle assembly checkpoint (GO:0007094)2.82535671
165regulation of mitotic sister chromatid separation (GO:0010965)2.80686329
166regulation of mitotic sister chromatid segregation (GO:0033047)2.80686329
167regulation of sister chromatid segregation (GO:0033045)2.80686329
168negative regulation of mitotic sister chromatid separation (GO:2000816)2.80461421
169negative regulation of sister chromatid segregation (GO:0033046)2.80461421
170negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.80461421
171negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.80461421
172negative regulation of mitotic sister chromatid segregation (GO:0033048)2.80461421
173DNA modification (GO:0006304)2.78612625
174spindle assembly checkpoint (GO:0071173)2.76303385
175regulation of mitotic metaphase/anaphase transition (GO:0030071)2.75182507
176regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.75182507
177histone H4-K8 acetylation (GO:0043982)2.73180714
178histone H4-K5 acetylation (GO:0043981)2.73180714
179binding of sperm to zona pellucida (GO:0007339)2.72696272
180organelle fission (GO:0048285)2.72623479
181gamete generation (GO:0007276)2.72404452
182mitotic spindle checkpoint (GO:0071174)2.71777904
183mitotic sister chromatid cohesion (GO:0007064)2.69056806
184negative regulation of chromosome segregation (GO:0051985)2.68792481
185male gamete generation (GO:0048232)2.67071823
186centriole assembly (GO:0098534)2.66836790
187synapsis (GO:0007129)14.5777521
188chromosome organization involved in meiosis (GO:0070192)13.5764982
189synaptonemal complex assembly (GO:0007130)12.9059374
190male meiosis I (GO:0007141)12.3906819
191synaptonemal complex organization (GO:0070193)11.6312705
192male meiosis (GO:0007140)10.3141252

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.46764097
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.46764097
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.46764097
4SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.29747467
5RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.27851379
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.27005224
7ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.11165378
8IGF1R_20145208_ChIP-Seq_DFB_Human2.95003609
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.89157547
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.62168980
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.59085305
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.58382991
13SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.58014192
14NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.57038390
15CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.54267532
16SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.47404599
17EWS_26573619_Chip-Seq_HEK293_Human2.38487530
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.36078940
19FUS_26573619_Chip-Seq_HEK293_Human2.35487723
20POU5F1_16518401_ChIP-PET_MESCs_Mouse2.34725877
21TCF3_18692474_ChIP-Seq_MESCs_Mouse2.26895632
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.17047561
23NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.13360476
24ER_23166858_ChIP-Seq_MCF-7_Human2.10083213
25ZNF274_21170338_ChIP-Seq_K562_Hela2.08648407
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06946880
27TAF15_26573619_Chip-Seq_HEK293_Human2.06818837
28RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.06815677
29E2F7_22180533_ChIP-Seq_HELA_Human2.06217546
30BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.05793690
31MYC_18358816_ChIP-ChIP_MESCs_Mouse2.05139082
32YY1_21170310_ChIP-Seq_MESCs_Mouse2.01744026
33CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.97827639
34DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.97521318
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.93665799
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91876481
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.90569393
38MYC_19030024_ChIP-ChIP_MESCs_Mouse1.82349967
39KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.79669550
40TP53_22573176_ChIP-Seq_HFKS_Human1.78755360
41SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.78467326
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.77698844
43NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.74332451
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.74305464
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73282636
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.73037796
47ETS1_20019798_ChIP-Seq_JURKAT_Human1.70627564
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.68260454
49PU.1_20513432_ChIP-Seq_Bcells_Mouse1.66868733
50SOX2_18555785_ChIP-Seq_MESCs_Mouse1.65454941
51GBX2_23144817_ChIP-Seq_PC3_Human1.65283009
52P300_19829295_ChIP-Seq_ESCs_Human1.64350823
53NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.63241553
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.62761202
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62743303
56NANOG_21062744_ChIP-ChIP_HESCs_Human1.62457549
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.61719074
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.61569885
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.60923329
60RUNX1_26923725_Chip-Seq_HPCs_Mouse1.60313690
61BCAT_22108803_ChIP-Seq_LS180_Human1.59625161
62KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.57856549
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.57469288
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.57312277
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.56822104
66TCF3_18692474_ChIP-Seq_MEFs_Mouse1.56758287
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.54083460
68PRDM14_20953172_ChIP-Seq_ESCs_Human1.53269751
69HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.52652827
70RUNX2_22187159_ChIP-Seq_PCA_Human1.52120267
71PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.50906611
72AR_25329375_ChIP-Seq_VCAP_Human1.48647631
73EZH2_22144423_ChIP-Seq_EOC_Human1.47078280
74* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.46651390
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43933340
76POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.42546404
77NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.42392450
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.42233467
79MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42009662
80TCF4_23295773_ChIP-Seq_U87_Human1.41811851
81FLI1_27457419_Chip-Seq_LIVER_Mouse1.40710696
82CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39814826
83ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.39686026
84FOXA1_21572438_ChIP-Seq_LNCaP_Human1.39519939
85* STAT3_23295773_ChIP-Seq_U87_Human1.39409552
86SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38320484
87E2F1_18555785_ChIP-Seq_MESCs_Mouse1.38182966
88TET1_21451524_ChIP-Seq_MESCs_Mouse1.36419204
89TAL1_26923725_Chip-Seq_HPCs_Mouse1.35366805
90FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34896984
91NANOG_18692474_ChIP-Seq_MESCs_Mouse1.34791588
92MYC_18940864_ChIP-ChIP_HL60_Human1.34359124
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33990485
94GATA3_26560356_Chip-Seq_TH1_Human1.32940624
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32666308
96DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.29619572
97POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29375761
98SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.28103983
99ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27838072
100PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.26821350
101SPI1_26923725_Chip-Seq_HPCs_Mouse1.25646404
102FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.25229122
103CBP_20019798_ChIP-Seq_JUKART_Human1.23654640
104IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23654640
105TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.22526186
106SMAD4_21799915_ChIP-Seq_A2780_Human1.22195028
107PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21173598
108FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20986323
109FOXA1_25329375_ChIP-Seq_VCAP_Human1.20986323
110STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20413419
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20291258
112SOX2_18692474_ChIP-Seq_MESCs_Mouse1.19928828
113MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.19614197
114TTF2_22483619_ChIP-Seq_HELA_Human1.19010414
115IRF1_19129219_ChIP-ChIP_H3396_Human1.18607992
116RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18310070
117EST1_17652178_ChIP-ChIP_JURKAT_Human1.17632916
118CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.16943618
119YY1_22570637_ChIP-Seq_MALME-3M_Human1.16291539
120KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16211098
121GABP_19822575_ChIP-Seq_HepG2_Human1.15826982
122DCP1A_22483619_ChIP-Seq_HELA_Human1.15416585
123E2F4_17652178_ChIP-ChIP_JURKAT_Human1.14277814
124SMAD4_21741376_ChIP-Seq_EPCs_Human1.13431136
125SOX2_19829295_ChIP-Seq_ESCs_Human1.13235843
126NANOG_19829295_ChIP-Seq_ESCs_Human1.13235843
127VDR_21846776_ChIP-Seq_THP-1_Human1.13129633
128ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12974641
129CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12823915
130AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12156630
131* RNF2_27304074_Chip-Seq_NSC_Mouse1.11411252
132SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11381113
133VDR_22108803_ChIP-Seq_LS180_Human1.11158963
134E2F1_21310950_ChIP-Seq_MCF-7_Human1.09890369
135VDR_23849224_ChIP-Seq_CD4+_Human1.08294667
136AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08223210
137PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07757482
138TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.07403495
139NANOG_16518401_ChIP-PET_MESCs_Mouse1.06599705
140TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05059920
141REST_21632747_ChIP-Seq_MESCs_Mouse1.04743804
142CREB1_15753290_ChIP-ChIP_HEK293T_Human1.03991284
143ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03719677
144POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02939082
145CBX2_27304074_Chip-Seq_ESCs_Mouse1.02920797
146RARB_24833708_ChIP-Seq_LIVER_Mouse1.02549285
147SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01979387
148PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01506811
149ETS1_21867929_ChIP-Seq_TH2_Mouse1.01304392
150HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01291999
151FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01034006
152CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00659108
153STAT3_18555785_ChIP-Seq_MESCs_Mouse0.99705662
154RARA_24833708_ChIP-Seq_LIVER_Mouse0.99651768
155TCF4_22108803_ChIP-Seq_LS180_Human0.99234449
156SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98963457
157POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.98914293
158IRF8_21731497_ChIP-ChIP_J774_Mouse0.98642961
159KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.98541066
160CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98221977
161GABP_17652178_ChIP-ChIP_JURKAT_Human0.98075704
162CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97537435
163PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97019352
164FOXM1_23109430_ChIP-Seq_U2OS_Human0.96829880
165* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96773542
166GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96701121
167FOXH1_21741376_ChIP-Seq_EPCs_Human0.96646354
168EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.96160769
169KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95892126
170TP53_16413492_ChIP-PET_HCT116_Human0.95370029
171RXRA_24833708_ChIP-Seq_LIVER_Mouse0.95331239
172SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.94733327
173TBX3_20139965_ChIP-Seq_ESCs_Mouse0.94448212
174STAT1_20625510_ChIP-Seq_HELA_Human0.94304366
175ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94106783
176SOX2_18692474_ChIP-Seq_MEFs_Mouse0.94024100
177ETV1_20927104_ChIP-Seq_GIST48_Human0.93628372
178* HTT_18923047_ChIP-ChIP_STHdh_Human0.93519622
179* NANOG_18555785_Chip-Seq_ESCs_Mouse0.93219049
180EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93218973
181SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91341634
182CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91270268
183POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90566509
184TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90566509
185FOXP3_21729870_ChIP-Seq_TREG_Human0.89661065

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.50006525
2MP0005171_absent_coat_pigmentation5.04192618
3MP0008877_abnormal_DNA_methylation4.47967774
4MP0002160_abnormal_reproductive_system3.72481731
5MP0002009_preneoplasia3.55672289
6MP0010094_abnormal_chromosome_stability2.78268870
7MP0002234_abnormal_pharynx_morphology2.77705486
8MP0010030_abnormal_orbit_morphology2.67184977
9MP0008961_abnormal_basal_metabolism2.57580588
10MP0005389_reproductive_system_phenotype2.51395307
11MP0008995_early_reproductive_senescence2.49995726
12MP0004233_abnormal_muscle_weight2.41286772
13MP0006072_abnormal_retinal_apoptosis2.37426751
14MP0003890_abnormal_embryonic-extraembry2.36369208
15MP0008789_abnormal_olfactory_epithelium2.22868373
16MP0009278_abnormal_bone_marrow2.19834336
17MP0000678_abnormal_parathyroid_gland2.18769181
18MP0004133_heterotaxia2.15895806
19MP0002653_abnormal_ependyma_morphology2.15462889
20MP0005174_abnormal_tail_pigmentation2.08246406
21MP0003136_yellow_coat_color1.98087564
22MP0006292_abnormal_olfactory_placode1.96951646
23MP0003786_premature_aging1.96698596
24MP0003646_muscle_fatigue1.91921857
25MP0003111_abnormal_nucleus_morphology1.91300585
26MP0002249_abnormal_larynx_morphology1.85657054
27MP0008058_abnormal_DNA_repair1.85451105
28MP0008932_abnormal_embryonic_tissue1.82862613
29MP0008007_abnormal_cellular_replicative1.68942953
30MP0003718_maternal_effect1.68704096
31MP0003656_abnormal_erythrocyte_physiolo1.68306967
32MP0005645_abnormal_hypothalamus_physiol1.67674405
33MP0005499_abnormal_olfactory_system1.67414356
34MP0005394_taste/olfaction_phenotype1.67414356
35MP0004957_abnormal_blastocyst_morpholog1.67269785
36MP0002822_catalepsy1.66579142
37MP0001929_abnormal_gametogenesis1.65060722
38MP0009046_muscle_twitch1.63726854
39MP0003119_abnormal_digestive_system1.62386300
40MP0000015_abnormal_ear_pigmentation1.61708086
41MP0004782_abnormal_surfactant_physiolog1.57650180
42MP0003283_abnormal_digestive_organ1.57422009
43MP0002210_abnormal_sex_determination1.55459713
44MP0000579_abnormal_nail_morphology1.50641437
45MP0003698_abnormal_male_reproductive1.45609118
46MP0001145_abnormal_male_reproductive1.45070521
47MP0003693_abnormal_embryo_hatching1.44706038
48MP0005410_abnormal_fertilization1.43181089
49MP0002396_abnormal_hematopoietic_system1.42636028
50MP0000427_abnormal_hair_cycle1.40969470
51MP0000383_abnormal_hair_follicle1.39684797
52MP0004142_abnormal_muscle_tone1.37477695
53MP0005409_darkened_coat_color1.36441831
54MP0002572_abnormal_emotion/affect_behav1.35890417
55MP0004808_abnormal_hematopoietic_stem1.35302978
56MP0003183_abnormal_peptide_metabolism1.33247483
57MP0001986_abnormal_taste_sensitivity1.32623065
58MP0000569_abnormal_digit_pigmentation1.32513373
59MP0008004_abnormal_stomach_pH1.30545118
60MP0005075_abnormal_melanosome_morpholog1.30347596
61MP0003077_abnormal_cell_cycle1.29260912
62MP0000653_abnormal_sex_gland1.24553730
63MP0004859_abnormal_synaptic_plasticity1.23216635
64MP0002139_abnormal_hepatobiliary_system1.21094090
65MP0002282_abnormal_trachea_morphology1.20090551
66MP0005253_abnormal_eye_physiology1.18317323
67MP0001293_anophthalmia1.15915902
68MP0002084_abnormal_developmental_patter1.15860771
69MP0001697_abnormal_embryo_size1.13337579
70MP0002063_abnormal_learning/memory/cond1.12537022
71MP0002085_abnormal_embryonic_tissue1.10527028
72MP0000955_abnormal_spinal_cord1.09013372
73MP0010678_abnormal_skin_adnexa1.06931037
74MP0001545_abnormal_hematopoietic_system1.06481787
75MP0005397_hematopoietic_system_phenotyp1.06481787
76MP0003880_abnormal_central_pattern1.05905199
77MP0002161_abnormal_fertility/fecundity1.05863217
78MP0003937_abnormal_limbs/digits/tail_de1.05635827
79MP0001188_hyperpigmentation1.04074926
80MP0000470_abnormal_stomach_morphology1.01350164
81MP0003137_abnormal_impulse_conducting0.99758817
82MP0002064_seizures0.97276606
83MP0001485_abnormal_pinna_reflex0.94243204
84MP0000639_abnormal_adrenal_gland0.93037365
85MP0002751_abnormal_autonomic_nervous0.91665102
86MP0002735_abnormal_chemical_nociception0.91394945
87MP0001502_abnormal_circadian_rhythm0.91219159
88MP0003755_abnormal_palate_morphology0.90846596
89MP0005423_abnormal_somatic_nervous0.90193751
90MP0002086_abnormal_extraembryonic_tissu0.89535775
91MP0001340_abnormal_eyelid_morphology0.88966618
92MP0001970_abnormal_pain_threshold0.88004811
93MP0000516_abnormal_urinary_system0.87793337
94MP0005367_renal/urinary_system_phenotyp0.87793337
95MP0000350_abnormal_cell_proliferation0.86896647
96MP0002075_abnormal_coat/hair_pigmentati0.86398904
97MP0003567_abnormal_fetal_cardiomyocyte0.85193700
98MP0001186_pigmentation_phenotype0.84043847
99MP0000778_abnormal_nervous_system0.80980286
100MP0005395_other_phenotype0.80893463
101MP0002272_abnormal_nervous_system0.80478226
102MP0002233_abnormal_nose_morphology0.79936662
103MP0000462_abnormal_digestive_system0.79096327
104MP0003699_abnormal_female_reproductive0.78569237
105MP0002114_abnormal_axial_skeleton0.78537634
106MP0001984_abnormal_olfaction0.78521604
107MP0002932_abnormal_joint_morphology0.78080146
108MP0001119_abnormal_female_reproductive0.77465118
109MP0002116_abnormal_craniofacial_bone0.77229831
110MP0003861_abnormal_nervous_system0.77074004
111MP0002067_abnormal_sensory_capabilities0.76992578
112MP0002269_muscular_atrophy0.76966695
113MP0000490_abnormal_crypts_of0.75968206
114MP0003936_abnormal_reproductive_system0.75449089
115MP0001672_abnormal_embryogenesis/_devel0.75102642
116MP0005380_embryogenesis_phenotype0.75102642
117MP0002163_abnormal_gland_morphology0.74677600
118MP0002138_abnormal_hepatobiliary_system0.74462147
119MP0001919_abnormal_reproductive_system0.74413791
120MP0004197_abnormal_fetal_growth/weight/0.74404283
121MP0001324_abnormal_eye_pigmentation0.74198044
122MP0003121_genomic_imprinting0.74133773
123MP0000566_synostosis0.73718333
124MP0000049_abnormal_middle_ear0.73198456
125MP0003635_abnormal_synaptic_transmissio0.72819595
126MP0010307_abnormal_tumor_latency0.72252630
127MP0003453_abnormal_keratinocyte_physiol0.71901971
128MP0003935_abnormal_craniofacial_develop0.70828727
129MP0000631_abnormal_neuroendocrine_gland0.70769866
130MP0002882_abnormal_neuron_morphology0.70674257
131MP0001664_abnormal_digestion0.70420678
132MP0002733_abnormal_thermal_nociception0.69455650
133MP0001730_embryonic_growth_arrest0.67793000
134MP0002152_abnormal_brain_morphology0.67707673
135MP0001666_abnormal_nutrient_absorption0.67669236
136MP0005195_abnormal_posterior_eye0.67231291
137MP0002752_abnormal_somatic_nervous0.66965471
138MP0006035_abnormal_mitochondrial_morpho0.63905428
139MP0005551_abnormal_eye_electrophysiolog0.58545390
140MP0004215_abnormal_myocardial_fiber0.57921651
141MP0003868_abnormal_feces_composition0.54119083
142MP0005386_behavior/neurological_phenoty0.53648196
143MP0004924_abnormal_behavior0.53648196
144MP0001529_abnormal_vocalization0.51374748
145MP0002095_abnormal_skin_pigmentation0.50680787
146MP0009745_abnormal_behavioral_response0.47072197
147MP0009250_abnormal_appendicular_skeleto0.46646768
148MP0002277_abnormal_respiratory_mucosa0.45566062
149MP0003115_abnormal_respiratory_system0.45128386
150MP0000313_abnormal_cell_death0.43497449
151MP0001963_abnormal_hearing_physiology0.43394990
152MP0001764_abnormal_homeostasis0.41797946
153MP0005647_abnormal_sex_gland0.40203262
154MP0006036_abnormal_mitochondrial_physio0.37865070
155MP0000465_gastrointestinal_hemorrhage0.37570090
156MP0000647_abnormal_sebaceous_gland0.37424347

Predicted human phenotypes

RankGene SetZ-score
1Azoospermia (HP:0000027)5.81331951
2Gonadotropin excess (HP:0000837)5.60870682
3Spontaneous abortion (HP:0005268)4.86327998
4Concave nail (HP:0001598)4.49714339
5Rectal fistula (HP:0100590)4.45944740
6Rectovaginal fistula (HP:0000143)4.45944740
7Annular pancreas (HP:0001734)4.40261922
8Abnormal spermatogenesis (HP:0008669)4.39131526
9Rib fusion (HP:0000902)4.34799400
10Oligodactyly (hands) (HP:0001180)4.31448673
11Lip pit (HP:0100267)4.28897092
12Abnormality of the renal collecting system (HP:0004742)4.25304996
13Facial hemangioma (HP:0000329)4.19009349
14Increased IgM level (HP:0003496)4.12211427
15Intestinal fistula (HP:0100819)4.07287392
16Horizontal nystagmus (HP:0000666)3.91914128
17Intestinal atresia (HP:0011100)3.83028611
18Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.79735935
19Type I transferrin isoform profile (HP:0003642)3.78277823
20Capillary hemangiomas (HP:0005306)3.75424877
21Shoulder girdle muscle weakness (HP:0003547)3.73531800
22Male infertility (HP:0003251)3.73172698
23Abnormality of cochlea (HP:0000375)3.65083603
24Vaginal fistula (HP:0004320)3.62724459
25Abnormal respiratory motile cilium morphology (HP:0005938)3.58043812
26Abnormal respiratory epithelium morphology (HP:0012253)3.58043812
27Absent radius (HP:0003974)3.55448482
2811 pairs of ribs (HP:0000878)3.53321221
29Degeneration of the lateral corticospinal tracts (HP:0002314)3.40616981
30Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.40616981
31Aplasia involving forearm bones (HP:0009822)3.37702498
32Absent forearm bone (HP:0003953)3.37702498
33Tubulointerstitial nephritis (HP:0001970)3.37497790
34Abnormality of male internal genitalia (HP:0000022)3.30791307
35Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.25188280
36Abnormal protein N-linked glycosylation (HP:0012347)3.25188280
37Abnormal protein glycosylation (HP:0012346)3.25188280
38Abnormal glycosylation (HP:0012345)3.25188280
39Absent thumb (HP:0009777)3.17259272
40Absent rod-and cone-mediated responses on ERG (HP:0007688)3.13568546
41Osteomalacia (HP:0002749)3.13006546
42Nephrogenic diabetes insipidus (HP:0009806)3.12536500
43Rimmed vacuoles (HP:0003805)3.07861026
44Hypochromic microcytic anemia (HP:0004840)3.07804728
45Poikiloderma (HP:0001029)3.06242419
46Broad alveolar ridges (HP:0000187)3.03692764
47Papillary thyroid carcinoma (HP:0002895)3.03050220
48Pustule (HP:0200039)3.01160230
49Abnormality of the labia minora (HP:0012880)3.00796032
50Patellar aplasia (HP:0006443)2.98293066
51Tongue fasciculations (HP:0001308)2.97736723
52Alopecia of scalp (HP:0002293)2.96085406
53Aplasia/hypoplasia of the humerus (HP:0006507)2.94534625
54Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.86861184
55Gait imbalance (HP:0002141)2.83138716
56Abnormality of the intrinsic pathway (HP:0010989)2.81423749
57Oligodactyly (HP:0012165)2.78670445
58Amyotrophic lateral sclerosis (HP:0007354)2.77821759
59Congenital primary aphakia (HP:0007707)2.77058832
60Chromosomal breakage induced by crosslinking agents (HP:0003221)2.74319393
61Short humerus (HP:0005792)2.74246617
62Abnormality of the ileum (HP:0001549)2.71662153
63Abnormal hemoglobin (HP:0011902)2.70485476
64Aplasia/Hypoplasia of the patella (HP:0006498)2.70473691
65Medial flaring of the eyebrow (HP:0010747)2.70438444
66Morphological abnormality of the inner ear (HP:0011390)2.70258362
67Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.70023688
68Short 1st metacarpal (HP:0010034)2.70023688
69Duplicated collecting system (HP:0000081)2.69579364
70Alacrima (HP:0000522)2.64983022
71Orthostatic hypotension (HP:0001278)2.64729626
72Impaired vibration sensation in the lower limbs (HP:0002166)2.60792069
73Type 2 muscle fiber atrophy (HP:0003554)2.59563197
74Median cleft lip (HP:0000161)2.59217524
75Large hands (HP:0001176)2.55079365
76Muscle fibrillation (HP:0010546)2.54315058
77Short chin (HP:0000331)2.53298991
78Chromsome breakage (HP:0040012)2.51280214
79Clumsiness (HP:0002312)2.50659288
80Abnormal lung lobation (HP:0002101)2.49902708
81Anteriorly placed anus (HP:0001545)2.49102709
82Widely spaced teeth (HP:0000687)2.47630513
83Turricephaly (HP:0000262)2.47183809
84Nephronophthisis (HP:0000090)2.46165508
85Small intestinal stenosis (HP:0012848)2.46138348
86Duodenal stenosis (HP:0100867)2.46138348
87Atrophy/Degeneration involving motor neurons (HP:0007373)2.45028403
88Abnormality of the corticospinal tract (HP:0002492)2.41841304
89Muscle fiber atrophy (HP:0100295)2.40103275
90Coronal craniosynostosis (HP:0004440)2.37663989
91Supernumerary spleens (HP:0009799)2.37409438
92Hypoplasia of the radius (HP:0002984)2.35279699
93Congenital hip dislocation (HP:0001374)2.34312233
94Abnormality of the 1st metacarpal (HP:0010009)2.33555183
95Infertility (HP:0000789)2.30833382
96Premature graying of hair (HP:0002216)2.29729143
97Poor coordination (HP:0002370)2.28134771
98Ectopic kidney (HP:0000086)2.27089416
99Premature ovarian failure (HP:0008209)2.26807785
100Abnormality of midbrain morphology (HP:0002418)2.26165299
101Molar tooth sign on MRI (HP:0002419)2.26165299
102Aplasia/Hypoplasia of the tibia (HP:0005772)2.24832157
103Abnormality of the renal medulla (HP:0100957)2.24554259
104Short tibia (HP:0005736)2.24367717
105Dysautonomia (HP:0002459)2.22632600
106Exertional dyspnea (HP:0002875)2.22380361
107Febrile seizures (HP:0002373)2.21756655
108Volvulus (HP:0002580)2.20752374
109Abnormal respiratory motile cilium physiology (HP:0012261)2.19250903
110Abnormality of the lower motor neuron (HP:0002366)2.19107224
111Narrow nasal bridge (HP:0000446)2.18995857
112Gastrointestinal atresia (HP:0002589)2.17959341
113Increased nuchal translucency (HP:0010880)2.17825640
114Progressive sensorineural hearing impairment (HP:0000408)2.17322544
115Abnormality of chromosome stability (HP:0003220)2.17214549
116Vertebral arch anomaly (HP:0008438)2.16537479
117Pancreatic cysts (HP:0001737)2.16534927
118Abnormality of the aortic arch (HP:0012303)2.15681083
119Aplasia of the musculature (HP:0100854)2.13595491
120Abnormality of chromosome segregation (HP:0002916)2.12705993
121Breast hypoplasia (HP:0003187)2.12616867
122Decreased lacrimation (HP:0000633)2.11146639
123Atonic seizures (HP:0010819)2.11115464
124Vaginal atresia (HP:0000148)2.10516742
125Squamous cell carcinoma (HP:0002860)2.08100628
126Methylmalonic acidemia (HP:0002912)2.07753242
127Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.07497711
128Vertebral hypoplasia (HP:0008417)2.07497711
129Nephroblastoma (Wilms tumor) (HP:0002667)2.07315558
130Abnormal ciliary motility (HP:0012262)2.07189593
131Abnormality of DNA repair (HP:0003254)2.06849071
132Epileptic encephalopathy (HP:0200134)2.06123166
133Bulbar palsy (HP:0001283)2.05915281
134Ulnar bowing (HP:0003031)2.04761418
135Clitoromegaly (HP:0000057)2.04492026
136Non-midline cleft lip (HP:0100335)2.04178153
137Genital tract atresia (HP:0001827)2.03963411
138Amelogenesis imperfecta (HP:0000705)2.01640874
139Progressive cerebellar ataxia (HP:0002073)2.01439965
140Abnormal rod and cone electroretinograms (HP:0008323)2.01151179
141Abdominal situs inversus (HP:0003363)1.97475798
142Abnormality of abdominal situs (HP:0011620)1.97475798
143Upper motor neuron abnormality (HP:0002127)1.97302414
144Ketosis (HP:0001946)1.96349326
145Short thumb (HP:0009778)1.96249358
146Hypoplasia of the ulna (HP:0003022)1.95854649
147Abnormality of the duodenum (HP:0002246)1.95367374
148Acute lymphatic leukemia (HP:0006721)1.95359304
149Decreased testicular size (HP:0008734)1.94709349
150Choanal stenosis (HP:0000452)1.93068196
151Dynein arm defect of respiratory motile cilia (HP:0012255)1.93053049
152Absent/shortened dynein arms (HP:0200106)1.93053049
153Popliteal pterygium (HP:0009756)1.91181035
154Multicystic kidney dysplasia (HP:0000003)1.91148363
155Fair hair (HP:0002286)1.90755469
156True hermaphroditism (HP:0010459)1.90439312
157Aplasia/Hypoplasia of the uvula (HP:0010293)1.88432555
158Long foot (HP:0001833)1.88412248
159Truncal obesity (HP:0001956)1.88223698
160Hypotelorism (HP:0000601)1.87105872
161Embryonal renal neoplasm (HP:0011794)1.86406117
162Degeneration of anterior horn cells (HP:0002398)1.85950191
163Abnormality of the anterior horn cell (HP:0006802)1.85950191
164Hypotrichosis (HP:0001006)1.85593251
165Abnormality of placental membranes (HP:0011409)1.85109777
166Amniotic constriction ring (HP:0009775)1.85109777
167Meckel diverticulum (HP:0002245)1.83768430
168Aplasia/Hypoplasia of the sternum (HP:0006714)1.80421313
169Clubbing of toes (HP:0100760)1.77288230
170Scotoma (HP:0000575)1.75363867
171Attenuation of retinal blood vessels (HP:0007843)1.73128677
172Abnormality of the preputium (HP:0100587)1.71046036
173Sloping forehead (HP:0000340)1.69252702
174Hyperpituitarism (HP:0010514)1.67736168
175Wrist flexion contracture (HP:0001239)1.67586752
176Renal Fanconi syndrome (HP:0001994)1.66188302

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK9.33674546
2PNCK6.03050209
3EIF2AK34.78457510
4MAP3K64.63807007
5ICK4.60268273
6MAPK154.33769757
7DDR24.02494152
8PINK13.66504627
9MET3.53190811
10MAP3K113.32165806
11PRKD22.96957892
12AKT32.81272265
13TYRO32.67475858
14FGR2.50853362
15MATK2.46994593
16YES12.42559183
17PRPF4B2.26941785
18DAPK12.20282470
19UHMK12.07513355
20OXSR12.01040006
21CAMK1G1.92011054
22PTK2B1.87664583
23TLK11.63943430
24PIM21.62694107
25NEK91.60977682
26CSF1R1.60005480
27CHEK21.59533467
28CDK71.55522984
29CDC71.51989275
30LATS21.49437399
31DYRK1B1.45887731
32CSK1.45517687
33TRPM71.40654614
34PHKG21.34744890
35PHKG11.34744890
36MAP3K131.32115112
37CDC42BPA1.24012926
38BMX1.21887979
39PLK11.21671929
40DYRK31.21531423
41PRKCI1.17346456
42TAOK31.14760206
43FRK1.10264008
44PDGFRA1.09314543
45ARAF1.00095109
46SRPK10.94705860
47CDK90.93643589
48MAPK130.92290440
49CDK60.91499236
50PIM10.87695028
51MKNK20.87689739
52EIF2AK20.86790687
53NEK60.84954062
54VRK10.84850926
55RPS6KC10.83442200
56RPS6KL10.83442200
57HIPK20.81963069
58MAPK110.79906952
59CAMK2B0.79865897
60STK38L0.79466539
61DYRK20.78248490
62PRKAA10.76101513
63TAOK20.73963271
64STK160.72740071
65GRK10.72096788
66STK380.70818253
67RET0.69679010
68STK110.68689084
69BUB10.68669689
70AURKA0.68248902
71GSK3A0.67670168
72RPS6KA60.67582924
73PDK30.66845887
74PDK40.66845887
75CDK120.66461912
76CAMK2A0.66157738
77CASK0.62627291
78STK390.60757095
79EGFR0.58262205
80ZAK0.58086283
81TAF10.57999710
82ATR0.57136858
83PDK20.56698060
84PDGFRB0.56687757
85BRSK20.56483401
86MARK30.54235665
87CDK20.54008827
88CSNK2A10.53810626
89CAMK2G0.53460862
90CHEK10.49375765
91RAF10.49344843
92STK240.49173608
93CCNB10.48842391
94WEE10.48698001
95NUAK10.47962630
96NEK10.46864214
97PLK40.46730025
98MAPK100.46491638
99LYN0.45840710
100MAP3K40.45763347
101CDK190.45338151
102CSNK2A20.44428693
103BRAF0.44015078
104MAP2K70.44004594
105BRSK10.43544174
106SGK10.43305659
107RPS6KA10.42004671
108ATM0.41393766
109NME10.40904672
110RPS6KB10.40329664
111AURKB0.39767339
112PLK30.39651192
113TTK0.39349947
114CDK10.39227461
115KIT0.39051962
116EPHA40.37946356
117NTRK20.37648329
118CAMK2D0.37493220
119CDK30.36998429
120MOS0.36920481
121ACVR1B0.34247975
122CSNK1G10.33941579
123MAP3K90.33876271
124TGFBR20.33761876
125MAPK140.30679640
126TESK20.30138265
127WNK10.29544659
128BMPR1B0.29129260
129STK30.28993613
130WNK30.28394967
131CSNK1E0.27428141
132GSK3B0.27236293
133INSR0.26575832
134PRKAA20.26491864
135CDK80.25843799
136PRKCE0.25179487
137MAPK10.25005512
138TNIK0.24380111
139MTOR0.24047931
140ERBB30.23393635
141PLK20.23214415
142RPS6KA30.23054949
143PRKCZ0.22857633
144PTK20.22626826
145NME20.22469521
146NEK20.22327316
147KSR10.22089577
148MARK10.21833411
149RPS6KA40.21630563
150PRKG10.20583257
151ABL10.20419997
152MAP3K100.19895498
153AKT20.19197086
154CDK11A0.18696634
155MAP3K50.15396764
156MAPKAPK50.15376067
157PDK10.14586602
158CDK50.13476316

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.51885118
2Fatty acid biosynthesis_Homo sapiens_hsa000614.17387764
3Base excision repair_Homo sapiens_hsa034104.10945082
4DNA replication_Homo sapiens_hsa030303.61668326
5Propanoate metabolism_Homo sapiens_hsa006403.42660996
6Homologous recombination_Homo sapiens_hsa034403.19325849
7Fanconi anemia pathway_Homo sapiens_hsa034602.92016524
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.73783848
9Spliceosome_Homo sapiens_hsa030402.60087772
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.59909397
11Nucleotide excision repair_Homo sapiens_hsa034202.54611451
12Circadian rhythm_Homo sapiens_hsa047102.33277771
13mRNA surveillance pathway_Homo sapiens_hsa030152.27903787
14RNA transport_Homo sapiens_hsa030132.21422268
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.19606755
16N-Glycan biosynthesis_Homo sapiens_hsa005102.12651887
17Non-homologous end-joining_Homo sapiens_hsa034502.04217285
18Ribosome_Homo sapiens_hsa030102.01152512
19Basal transcription factors_Homo sapiens_hsa030221.99925252
20Regulation of autophagy_Homo sapiens_hsa041401.91379791
21Cell cycle_Homo sapiens_hsa041101.82845165
22Nicotine addiction_Homo sapiens_hsa050331.76010051
23Hedgehog signaling pathway_Homo sapiens_hsa043401.68392914
24Oocyte meiosis_Homo sapiens_hsa041141.64383663
25Sulfur relay system_Homo sapiens_hsa041221.47272818
26RNA polymerase_Homo sapiens_hsa030201.42246353
27Arginine and proline metabolism_Homo sapiens_hsa003301.39372313
28p53 signaling pathway_Homo sapiens_hsa041151.28701466
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27545279
30Wnt signaling pathway_Homo sapiens_hsa043101.26419388
31Hippo signaling pathway_Homo sapiens_hsa043901.21758040
32mTOR signaling pathway_Homo sapiens_hsa041501.17175983
33Retinol metabolism_Homo sapiens_hsa008301.16417811
34RNA degradation_Homo sapiens_hsa030181.11397377
35Proteasome_Homo sapiens_hsa030501.08693640
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07895781
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.07415073
38Caffeine metabolism_Homo sapiens_hsa002321.07155053
39Huntingtons disease_Homo sapiens_hsa050161.03058113
40Notch signaling pathway_Homo sapiens_hsa043301.02085558
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99976469
42Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.96296714
43Dorso-ventral axis formation_Homo sapiens_hsa043200.96115005
44Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94818412
45Amphetamine addiction_Homo sapiens_hsa050310.94209885
46ABC transporters_Homo sapiens_hsa020100.89648555
47Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82898873
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81979978
49Primary immunodeficiency_Homo sapiens_hsa053400.81556693
50Pyrimidine metabolism_Homo sapiens_hsa002400.80355275
51Basal cell carcinoma_Homo sapiens_hsa052170.79971776
52GABAergic synapse_Homo sapiens_hsa047270.79644226
53Selenocompound metabolism_Homo sapiens_hsa004500.79526366
54Long-term depression_Homo sapiens_hsa047300.79445411
55Asthma_Homo sapiens_hsa053100.78528362
56Glutamatergic synapse_Homo sapiens_hsa047240.78524161
57Folate biosynthesis_Homo sapiens_hsa007900.77931697
58TGF-beta signaling pathway_Homo sapiens_hsa043500.77188385
59Adherens junction_Homo sapiens_hsa045200.76465824
60Linoleic acid metabolism_Homo sapiens_hsa005910.73614187
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72912957
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70281765
63Starch and sucrose metabolism_Homo sapiens_hsa005000.69613448
64Oxidative phosphorylation_Homo sapiens_hsa001900.66507239
65Gap junction_Homo sapiens_hsa045400.64259389
66Biosynthesis of amino acids_Homo sapiens_hsa012300.64168793
67Renin-angiotensin system_Homo sapiens_hsa046140.64155368
68Long-term potentiation_Homo sapiens_hsa047200.60634125
69HTLV-I infection_Homo sapiens_hsa051660.60610645
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.60503490
71Olfactory transduction_Homo sapiens_hsa047400.58812631
72Lysine degradation_Homo sapiens_hsa003100.57453158
73Phototransduction_Homo sapiens_hsa047440.56265323
74Choline metabolism in cancer_Homo sapiens_hsa052310.55693637
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.55634489
76Ovarian steroidogenesis_Homo sapiens_hsa049130.54055834
77Colorectal cancer_Homo sapiens_hsa052100.53695256
78Parkinsons disease_Homo sapiens_hsa050120.53214950
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53008003
80ErbB signaling pathway_Homo sapiens_hsa040120.52931694
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52282161
82Fructose and mannose metabolism_Homo sapiens_hsa000510.51218801
83Morphine addiction_Homo sapiens_hsa050320.50127092
84VEGF signaling pathway_Homo sapiens_hsa043700.48750624
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48385057
86Thyroid cancer_Homo sapiens_hsa052160.47895919
87Bladder cancer_Homo sapiens_hsa052190.47814873
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.47686849
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47530589
90Arachidonic acid metabolism_Homo sapiens_hsa005900.46146541
91Cardiac muscle contraction_Homo sapiens_hsa042600.45776182
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45377587
93Small cell lung cancer_Homo sapiens_hsa052220.44215782
94Ether lipid metabolism_Homo sapiens_hsa005650.43792838
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43368020
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42767592
97Taste transduction_Homo sapiens_hsa047420.42669938
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40033215
99Synaptic vesicle cycle_Homo sapiens_hsa047210.39659681
100Tight junction_Homo sapiens_hsa045300.38342860
101MAPK signaling pathway_Homo sapiens_hsa040100.37782427
102Vitamin digestion and absorption_Homo sapiens_hsa049770.36923058
103T cell receptor signaling pathway_Homo sapiens_hsa046600.36007134
104Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.35462757
105Purine metabolism_Homo sapiens_hsa002300.35250980
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34515472
107Dopaminergic synapse_Homo sapiens_hsa047280.34323934
108Protein export_Homo sapiens_hsa030600.34237427
109MicroRNAs in cancer_Homo sapiens_hsa052060.34208736
110Cysteine and methionine metabolism_Homo sapiens_hsa002700.33758768
111cAMP signaling pathway_Homo sapiens_hsa040240.32113890
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31481654
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.31231527
114Epstein-Barr virus infection_Homo sapiens_hsa051690.30904767
115Serotonergic synapse_Homo sapiens_hsa047260.29832278
116Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29776593
117Autoimmune thyroid disease_Homo sapiens_hsa053200.28877805
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.25105248
119Shigellosis_Homo sapiens_hsa051310.24693055
120Inositol phosphate metabolism_Homo sapiens_hsa005620.23643133
121beta-Alanine metabolism_Homo sapiens_hsa004100.23407098
122GnRH signaling pathway_Homo sapiens_hsa049120.23062119
123Graft-versus-host disease_Homo sapiens_hsa053320.22721993
124Allograft rejection_Homo sapiens_hsa053300.22689940
125Alzheimers disease_Homo sapiens_hsa050100.22228181
126Salivary secretion_Homo sapiens_hsa049700.22202311
127Pyruvate metabolism_Homo sapiens_hsa006200.21500893
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19844529
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19272942
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.18706208
131NOD-like receptor signaling pathway_Homo sapiens_hsa046210.18666053
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.16894484
133Metabolic pathways_Homo sapiens_hsa011000.16543020
134Type I diabetes mellitus_Homo sapiens_hsa049400.15809300
135Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15336929
136Melanogenesis_Homo sapiens_hsa049160.14982867
137Phenylalanine metabolism_Homo sapiens_hsa003600.14558620
138Legionellosis_Homo sapiens_hsa051340.14071944
139Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.13869692
140Herpes simplex infection_Homo sapiens_hsa051680.13422911
141Calcium signaling pathway_Homo sapiens_hsa040200.12924496
142Mineral absorption_Homo sapiens_hsa049780.12772118
143Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.12030551
144Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.11345023
145Phosphatidylinositol signaling system_Homo sapiens_hsa040700.11156013
146Chemical carcinogenesis_Homo sapiens_hsa052040.10899454
147PI3K-Akt signaling pathway_Homo sapiens_hsa041510.07441342

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