ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	9.67220197
2	motile cilium assembly (GO:0044458)	9.64167073
3	epithelial cilium movement (GO:0003351)	9.55729662
4	left/right pattern formation (GO:0060972)	7.11850331
5	axoneme assembly (GO:0035082)	6.62063496
6	intraciliary transport (GO:0042073)	5.79666886
7	regulation of cilium movement (GO:0003352)	5.78071249
8	cilium organization (GO:0044782)	5.07049963
9	cilium assembly (GO:0042384)	4.99991381
10	left/right axis specification (GO:0070986)	4.97001362
11	ventricular system development (GO:0021591)	4.66519887
12	microtubule bundle formation (GO:0001578)	4.34873443
13	protein localization to cilium (GO:0061512)	4.06959787
14	centriole assembly (GO:0098534)	3.97172646
15	nonmotile primary cilium assembly (GO:0035058)	3.94961174
16	microtubule depolymerization (GO:0007019)	3.92744241
17	vitamin transmembrane transport (GO:0035461)	3.91860408
18	cilium morphogenesis (GO:0060271)	3.90249731
19	regulation of microtubule-based movement (GO:0060632)	3.82363311
20	primary alcohol catabolic process (GO:0034310)	3.78586846
21	cellular component assembly involved in morphogenesis (GO:0010927)	3.73786091
22	lateral sprouting from an epithelium (GO:0060601)	3.72495061
23	microtubule-based movement (GO:0007018)	3.72103721
24	negative regulation of T cell differentiation in thymus (GO:0033085)	3.66833875
25	establishment of planar polarity (GO:0001736)	3.66169211
26	establishment of tissue polarity (GO:0007164)	3.66169211
27	lung epithelium development (GO:0060428)	3.63317859
28	establishment of apical/basal cell polarity (GO:0035089)	3.51361475
29	establishment of monopolar cell polarity (GO:0061162)	3.46319971
30	establishment or maintenance of monopolar cell polarity (GO:0061339)	3.46319971
31	smoothened signaling pathway (GO:0007224)	3.42010459
32	sperm capacitation (GO:0048240)	3.37444596
33	nucleoside diphosphate phosphorylation (GO:0006165)	3.24414093
34	microtubule polymerization or depolymerization (GO:0031109)	3.22929803
35	cell projection assembly (GO:0030031)	3.21949074
36	positive regulation of smoothened signaling pathway (GO:0045880)	3.19011938
37	centriole replication (GO:0007099)	3.17174825
38	determination of left/right symmetry (GO:0007368)	3.12469729
39	determination of bilateral symmetry (GO:0009855)	2.98967335
40	GTP biosynthetic process (GO:0006183)	2.98030197
41	camera-type eye morphogenesis (GO:0048593)	2.94768861
42	specification of symmetry (GO:0009799)	2.92701051
43	neuronal stem cell maintenance (GO:0097150)	2.88413818
44	planar cell polarity pathway involved in neural tube closure (GO:0090179)	2.86289528
45	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.85429809
46	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.82390524
47	UTP biosynthetic process (GO:0006228)	2.82092292
48	retinal rod cell development (GO:0046548)	2.80983737
49	regulation of smoothened signaling pathway (GO:0008589)	2.76501186
50	terpenoid biosynthetic process (GO:0016114)	2.74519439
51	ethanol metabolic process (GO:0006067)	2.71727051
52	aldehyde catabolic process (GO:0046185)	2.69750980
53	sperm motility (GO:0030317)	2.68807624
54	CTP biosynthetic process (GO:0006241)	2.64772478
55	CTP metabolic process (GO:0046036)	2.64772478
56	viral transcription (GO:0019083)	2.63256715
57	neuron projection extension involved in neuron projection guidance (GO:1902284)	2.62392401
58	axon extension involved in axon guidance (GO:0048846)	2.62392401
59	protein polyglutamylation (GO:0018095)	2.60884374
60	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	2.60580512
61	tongue development (GO:0043586)	2.59233973
62	limb development (GO:0060173)	2.56917496
63	appendage development (GO:0048736)	2.56917496
64	lateral ventricle development (GO:0021670)	2.55936592
65	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.55109420
66	intra-S DNA damage checkpoint (GO:0031573)	2.54815449
67	embryonic camera-type eye development (GO:0031076)	2.54083209
68	UTP metabolic process (GO:0046051)	2.53494713
69	diterpenoid biosynthetic process (GO:0016102)	2.52643521
70	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.52594639
71	dorsal/ventral neural tube patterning (GO:0021904)	2.52253085
72	translational termination (GO:0006415)	2.51187979
73	apical protein localization (GO:0045176)	2.50670808
74	microtubule-based process (GO:0007017)	2.50545261
75	heart looping (GO:0001947)	2.50105865
76	telencephalon development (GO:0021537)	2.48955085
77	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.44960217
78	base-excision repair, AP site formation (GO:0006285)	2.44847491
79	embryonic body morphogenesis (GO:0010172)	2.40666172
80	glomerular epithelial cell development (GO:0072310)	2.38478241
81	response to xenobiotic stimulus (GO:0009410)	2.38331950
82	one-carbon compound transport (GO:0019755)	2.36996015
83	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.35457671
84	retinoic acid metabolic process (GO:0042573)	2.34507628
85	ribosomal small subunit assembly (GO:0000028)	2.33783609
86	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.32123605
87	pyrimidine nucleotide catabolic process (GO:0006244)	2.32024438
88	embryonic heart tube morphogenesis (GO:0003143)	2.31275204
89	pattern specification involved in kidney development (GO:0061004)	2.31241506
90	organelle assembly (GO:0070925)	2.31217406
91	pyrimidine nucleobase catabolic process (GO:0006208)	2.29278097
92	cytoplasmic microtubule organization (GO:0031122)	2.28453477
93	dorsal/ventral pattern formation (GO:0009953)	2.27918813
94	microtubule severing (GO:0051013)	2.25107130
95	spermatid development (GO:0007286)	2.24274374
96	Wnt signaling pathway, planar cell polarity pathway (GO:0060071)	2.20087169
97	body morphogenesis (GO:0010171)	2.18308342
98	axonemal dynein complex assembly (GO:0070286)	14.8016617
99	cilium or flagellum-dependent cell motility (GO:0001539)	10.8969679
100	cilium movement (GO:0003341)	10.5308308

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.83717762
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.78874809
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.31014535
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.11843679
5	DROSHA_22980978_ChIP-Seq_HELA_Human	2.06598548
6	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.99569404
7	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.96839054
8	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.93211489
9	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.92126127
10	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.86092777
11	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.78995050
12	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.76658617
13	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.74897676
14	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.73366346
15	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.63665570
16	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.63122302
17	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.61371923
18	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.61256931
19	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.61096520
20	CTCF_27219007_Chip-Seq_Bcells_Human	1.58266865
21	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.54984335
22	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.54084297
23	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.52447802
24	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.51522299
25	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.50324455
26	VDR_22108803_ChIP-Seq_LS180_Human	1.49018795
27	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.48868514
28	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.48061357
29	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.43265144
30	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.41277045
31	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.41277045
32	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.40711913
33	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.40516362
34	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.38907718
35	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.34778816
36	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.29180443
37	RNF2_27304074_Chip-Seq_NSC_Mouse	1.28328666
38	SMC4_20622854_ChIP-Seq_HELA_Human	1.26504123
39	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.26049008
40	REST_21632747_ChIP-Seq_MESCs_Mouse	1.25712089
41	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.25623781
42	P68_20966046_ChIP-Seq_HELA_Human	1.22242078
43	IRF1_19129219_ChIP-ChIP_H3396_Human	1.17271142
44	XRN2_22483619_ChIP-Seq_HELA_Human	1.17064601
45	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.16006343
46	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.14192326
47	* CTCF_20526341_ChIP-Seq_ESCs_Human	1.11820851
48	ZNF263_19887448_ChIP-Seq_K562_Human	1.11531092
49	GABP_19822575_ChIP-Seq_HepG2_Human	1.10720810
50	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.09687254
51	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.09686718
52	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.09579680
53	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.08714781
54	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.06702057
55	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06442671
56	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.05734827
57	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.05558420
58	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.05114273
59	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.05042919
60	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.04983614
61	AR_21572438_ChIP-Seq_LNCaP_Human	1.04953526
62	PHF8_20622854_ChIP-Seq_HELA_Human	1.04265666
63	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.03772061
64	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.02085560
65	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.01571422
66	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.01025711
67	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01025711
68	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.00145997
69	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.99681478
70	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.99419227
71	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.99164319
72	ZNF274_21170338_ChIP-Seq_K562_Hela	0.99087974
73	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.99064677
74	SOX3_22085726_ChIP-Seq_NPCs_Mouse	0.96447601
75	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.96385226
76	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.95221889
77	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.95102830
78	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.94466848
79	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.93540603
80	TTF2_22483619_ChIP-Seq_HELA_Human	0.93376555
81	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.93094808
82	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.92760248
83	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.89817387
84	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.89275189
85	TP63_22573176_ChIP-Seq_HFKS_Human	0.88913864
86	MYC_18940864_ChIP-ChIP_HL60_Human	0.88375309
87	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.88327969
88	ERA_21632823_ChIP-Seq_H3396_Human	0.85743668
89	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.82820136
90	CREB1_26743006_Chip-Seq_LNCaP_Human	0.82784856
91	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.82637544
92	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.82402183
93	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.81270713
94	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.80820079
95	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.79992992
96	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.79426763
97	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	0.78896426
98	E2F1_20622854_ChIP-Seq_HELA_Human	0.78691425
99	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.78418400
100	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.78386616

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002653_abnormal_ependyma_morphology	5.51744817
2	MP0003136_yellow_coat_color	3.48884858
3	MP0000566_synostosis	3.33521369
4	MP0010030_abnormal_orbit_morphology	3.12551416
5	MP0008789_abnormal_olfactory_epithelium	3.09946637
6	MP0006292_abnormal_olfactory_placode	2.80797681
7	MP0005394_taste/olfaction_phenotype	2.74749017
8	MP0005499_abnormal_olfactory_system	2.74749017
9	MP0001984_abnormal_olfaction	2.57802380
10	MP0004133_heterotaxia	2.57352809
11	MP0005377_hearing/vestibular/ear_phenot	2.57061343
12	MP0003878_abnormal_ear_physiology	2.57061343
13	MP0009379_abnormal_foot_pigmentation	2.40561073
14	MP0008875_abnormal_xenobiotic_pharmacok	2.25446213
15	MP0002249_abnormal_larynx_morphology	2.23631161
16	MP0000049_abnormal_middle_ear	2.17482517
17	MP0001293_anophthalmia	2.09896947
18	MP0005623_abnormal_meninges_morphology	1.97177935
19	MP0001529_abnormal_vocalization	1.85780406
20	MP0002282_abnormal_trachea_morphology	1.80810100
21	MP0002277_abnormal_respiratory_mucosa	1.76478791
22	MP0003942_abnormal_urinary_system	1.72899399
23	MP0000778_abnormal_nervous_system	1.71827723
24	MP0002822_catalepsy	1.68562327
25	MP0002102_abnormal_ear_morphology	1.67689836
26	MP0002233_abnormal_nose_morphology	1.54031542
27	MP0003937_abnormal_limbs/digits/tail_de	1.52063827
28	MP0002132_abnormal_respiratory_system	1.50771363
29	MP0000026_abnormal_inner_ear	1.48351626
30	MP0003938_abnormal_ear_development	1.47734134
31	MP0001485_abnormal_pinna_reflex	1.44140374
32	MP0000631_abnormal_neuroendocrine_gland	1.39635937
33	MP0002160_abnormal_reproductive_system	1.28805687
34	MP0003861_abnormal_nervous_system	1.28677702
35	MP0005248_abnormal_Harderian_gland	1.28072259
36	MP0003283_abnormal_digestive_organ	1.25985414
37	MP0003122_maternal_imprinting	1.25258509
38	MP0003011_delayed_dark_adaptation	1.23804736
39	MP0001346_abnormal_lacrimal_gland	1.20573221
40	MP0000534_abnormal_ureter_morphology	1.17785076
41	MP0001286_abnormal_eye_development	1.16197954
42	MP0002638_abnormal_pupillary_reflex	1.15993901
43	MP0002092_abnormal_eye_morphology	1.13730726
44	MP0002116_abnormal_craniofacial_bone	1.12529473
45	MP0001299_abnormal_eye_distance/	1.12516774
46	MP0000955_abnormal_spinal_cord	1.11691820
47	MP0002697_abnormal_eye_size	1.10971537
48	MP0005391_vision/eye_phenotype	1.09404036
49	MP0006072_abnormal_retinal_apoptosis	1.08552584
50	MP0002752_abnormal_somatic_nervous	1.07046197
51	MP0002734_abnormal_mechanical_nocicepti	1.04945364
52	MP0002234_abnormal_pharynx_morphology	1.04423248
53	MP0003755_abnormal_palate_morphology	1.01844701
54	MP0000383_abnormal_hair_follicle	0.99403855
55	MP0005195_abnormal_posterior_eye	0.99218052
56	MP0003698_abnormal_male_reproductive	0.98363270
57	MP0004043_abnormal_pH_regulation	0.97656101
58	MP0008995_early_reproductive_senescence	0.97422065
59	MP0004859_abnormal_synaptic_plasticity	0.96675251
60	MP0005253_abnormal_eye_physiology	0.96451239
61	MP0002938_white_spotting	0.96201650
62	MP0005551_abnormal_eye_electrophysiolog	0.95965239
63	MP0002557_abnormal_social/conspecific_i	0.95208548
64	MP0002152_abnormal_brain_morphology	0.94855428
65	MP0001502_abnormal_circadian_rhythm	0.94127933
66	MP0004858_abnormal_nervous_system	0.92958688
67	MP0003119_abnormal_digestive_system	0.91739107
68	MP0001270_distended_abdomen	0.91369607
69	MP0000537_abnormal_urethra_morphology	0.88355828
70	MP0001929_abnormal_gametogenesis	0.87932030
71	MP0001963_abnormal_hearing_physiology	0.87776374
72	MP0009384_cardiac_valve_regurgitation	0.87637900
73	MP0002882_abnormal_neuron_morphology	0.85667606
74	MP0002932_abnormal_joint_morphology	0.84532636
75	MP0002572_abnormal_emotion/affect_behav	0.83501973
76	MP0005423_abnormal_somatic_nervous	0.83257766
77	MP0002210_abnormal_sex_determination	0.82991409
78	MP0002751_abnormal_autonomic_nervous	0.81832068
79	MP0002928_abnormal_bile_duct	0.81788396
80	MP0004019_abnormal_vitamin_homeostasis	0.80412943
81	MP0009053_abnormal_anal_canal	0.80233262
82	MP0009780_abnormal_chondrocyte_physiolo	0.79841967
83	MP0005503_abnormal_tendon_morphology	0.79692904
84	MP0006276_abnormal_autonomic_nervous	0.78968148
85	MP0000428_abnormal_craniofacial_morphol	0.78603001
86	MP0003880_abnormal_central_pattern	0.78030421
87	MP0002111_abnormal_tail_morphology	0.76772958
88	MP0000678_abnormal_parathyroid_gland	0.76141838
89	MP0004142_abnormal_muscle_tone	0.72803525
90	MP0002184_abnormal_innervation	0.72695583
91	MP0009745_abnormal_behavioral_response	0.72602999
92	MP0002084_abnormal_developmental_patter	0.71912005
93	MP0002085_abnormal_embryonic_tissue	0.70807255
94	MP0002735_abnormal_chemical_nociception	0.70646659
95	MP0002063_abnormal_learning/memory/cond	0.70201625
96	MP0003693_abnormal_embryo_hatching	0.70174332
97	MP0005083_abnormal_biliary_tract	0.69697169
98	MP0003935_abnormal_craniofacial_develop	0.69135582
99	MP0000613_abnormal_salivary_gland	0.68865020
100	MP0000762_abnormal_tongue_morphology	0.68470984

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal respiratory motile cilium physiology (HP:0012261)	9.21800440
2	Abnormal respiratory motile cilium morphology (HP:0005938)	8.77753981
3	Abnormal respiratory epithelium morphology (HP:0012253)	8.77753981
4	Abnormal ciliary motility (HP:0012262)	8.76870304
5	Dynein arm defect of respiratory motile cilia (HP:0012255)	8.48379306
6	Absent/shortened dynein arms (HP:0200106)	8.48379306
7	Rhinitis (HP:0012384)	7.96844774
8	Chronic bronchitis (HP:0004469)	6.46503704
9	Bronchiectasis (HP:0002110)	5.55147615
10	Nasal polyposis (HP:0100582)	4.71673505
11	Pancreatic fibrosis (HP:0100732)	4.19594565
12	Occipital encephalocele (HP:0002085)	4.10124676
13	True hermaphroditism (HP:0010459)	4.09211229
14	Abnormality of the nasal mucosa (HP:0000433)	3.74373469
15	Molar tooth sign on MRI (HP:0002419)	3.58370528
16	Abnormality of midbrain morphology (HP:0002418)	3.58370528
17	Nephronophthisis (HP:0000090)	3.54624030
18	Infertility (HP:0000789)	3.53159041
19	Pancreatic cysts (HP:0001737)	3.40248308
20	Cystic liver disease (HP:0006706)	3.24831827
21	Postaxial foot polydactyly (HP:0001830)	3.05215758
22	Chronic hepatic failure (HP:0100626)	2.92050677
23	Bronchitis (HP:0012387)	2.91110263
24	Gait imbalance (HP:0002141)	2.88627641
25	Medial flaring of the eyebrow (HP:0010747)	2.84604466
26	Atelectasis (HP:0100750)	2.84393245
27	Recurrent sinusitis (HP:0011108)	2.84368244
28	Male infertility (HP:0003251)	2.83196057
29	Congenital primary aphakia (HP:0007707)	2.81347476
30	Recurrent otitis media (HP:0000403)	2.75900360
31	Anencephaly (HP:0002323)	2.69160928
32	Abnormality of the renal medulla (HP:0100957)	2.66202412
33	Chronic sinusitis (HP:0011109)	2.63518502
34	Sclerocornea (HP:0000647)	2.63471938
35	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.53170519
36	Nephrogenic diabetes insipidus (HP:0009806)	2.50724064
37	Tubulointerstitial nephritis (HP:0001970)	2.34385140
38	Bell-shaped thorax (HP:0001591)	2.30756985
39	Congenital hepatic fibrosis (HP:0002612)	2.30158738
40	Postaxial hand polydactyly (HP:0001162)	2.29067240
41	Male pseudohermaphroditism (HP:0000037)	2.20444600
42	Tubular atrophy (HP:0000092)	2.18405024
43	Vaginal atresia (HP:0000148)	2.13040661
44	Genital tract atresia (HP:0001827)	2.12875631
45	Preaxial hand polydactyly (HP:0001177)	2.08578410
46	Poor coordination (HP:0002370)	2.05789332
47	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	10.5994306
48	Renal dysplasia (HP:0000110)	1.99015836
49	Septo-optic dysplasia (HP:0100842)	1.82028664
50	Anophthalmia (HP:0000528)	1.78776878
51	Abnormality of dentin (HP:0010299)	1.77530023
52	Oculomotor apraxia (HP:0000657)	1.74802921
53	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.74620704
54	Median cleft lip (HP:0000161)	1.73651079
55	Broad distal phalanx of finger (HP:0009836)	1.70160673
56	Optic nerve coloboma (HP:0000588)	1.68500096
57	Holoprosencephaly (HP:0001360)	1.64149797
58	Furrowed tongue (HP:0000221)	1.60947121
59	Rib fusion (HP:0000902)	1.60787331
60	Asplenia (HP:0001746)	1.58680617
61	Hyperactive renin-angiotensin system (HP:0000841)	1.57599003
62	Broad foot (HP:0001769)	1.57552432
63	Aplasia/Hypoplasia of the lens (HP:0008063)	1.55848796
64	Aganglionic megacolon (HP:0002251)	1.51230082
65	Abnormality of cells of the erythroid lineage (HP:0012130)	1.49512596
66	Chronic otitis media (HP:0000389)	1.48339534
67	Maternal diabetes (HP:0009800)	1.48198309
68	Narrow forehead (HP:0000341)	1.47207114
69	Multicystic kidney dysplasia (HP:0000003)	1.46790289
70	Short nail (HP:0001799)	1.45716716
71	Decreased testicular size (HP:0008734)	1.43822822
72	Stage 5 chronic kidney disease (HP:0003774)	1.41543397
73	Supernumerary spleens (HP:0009799)	1.41102720
74	Specific learning disability (HP:0001328)	1.40571457
75	Bile duct proliferation (HP:0001408)	1.40142000
76	Abnormal biliary tract physiology (HP:0012439)	1.40142000
77	Chorioretinal coloboma (HP:0000567)	1.39988430
78	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.38527655
79	Prominent nasal bridge (HP:0000426)	1.38472766
80	Tubulointerstitial abnormality (HP:0001969)	1.37225728
81	Nephropathy (HP:0000112)	1.36864204
82	Down-sloping shoulders (HP:0200021)	1.36111246
83	Abnormality of the dental root (HP:0006486)	1.35808303
84	Taurodontia (HP:0000679)	1.35808303
85	Abnormality of permanent molar morphology (HP:0011071)	1.35808303
86	Facial cleft (HP:0002006)	1.35752445
87	Abnormal number of erythroid precursors (HP:0012131)	1.35366176
88	Renal salt wasting (HP:0000127)	1.31552009
89	Short ribs (HP:0000773)	1.31087690
90	Retinitis pigmentosa (HP:0000510)	1.28613532
91	Abnormality of molar (HP:0011077)	1.26729140
92	Abnormality of molar morphology (HP:0011070)	1.26729140
93	Short thorax (HP:0010306)	1.26543054
94	Short femoral neck (HP:0100864)	1.25736947
95	Iris coloboma (HP:0000612)	1.24862840
96	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.24002166
97	Absent epiphyses (HP:0010577)	1.24002166
98	Depressed nasal ridge (HP:0000457)	1.22231633
99	Polydipsia (HP:0001959)	1.20369062
100	Abnormal drinking behavior (HP:0030082)	1.20369062

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAPK15	8.39821507
2	NME1	2.65149509
3	PNCK	2.62315786
4	TLK1	2.54354641
5	EPHB2	2.38688205
6	EPHA2	2.27260675
7	CDC7	2.18384289
8	INSRR	2.15188477
9	DYRK2	2.06437370
10	VRK2	1.89536869
11	CASK	1.68286644
12	MAP3K4	1.67114368
13	BCR	1.66424209
14	DYRK3	1.60740719
15	TTK	1.59631365
16	BCKDK	1.49707186
17	EEF2K	1.48534204
18	EPHA4	1.47525335
19	PASK	1.41402259
20	MAP2K7	1.41198849
21	CDK8	1.34553055
22	PLK4	1.32935588
23	VRK1	1.27818440
24	NEK2	1.26627505
25	WEE1	1.24977320
26	WNK4	1.19807828
27	AURKA	1.18166378
28	MST4	1.16370671
29	NTRK2	1.13855080
30	PRKD3	1.10956249
31	DYRK1B	1.09934200
32	MAPKAPK3	1.04624764
33	TRIB3	1.03012891
34	TESK1	1.02244991
35	BMPR1B	1.02137744
36	STK16	0.99893973
37	PLK1	0.97108616
38	CHEK2	0.94590917
39	MAP2K4	0.93107595
40	SMG1	0.92467776
41	TRIM28	0.89110332
42	LIMK1	0.88262329
43	ATR	0.85869651
44	MARK1	0.84411682
45	PRKCI	0.81511771
46	LRRK2	0.81056442
47	WNK3	0.80296212
48	EPHB1	0.80249985
49	SIK2	0.80101694
50	ZAK	0.78737595
51	PTK2B	0.77918221
52	RPS6KA5	0.77027637
53	MAPKAPK5	0.76207034
54	RPS6KA2	0.74688545
55	DYRK1A	0.74339820
56	NTRK1	0.73324546
57	CDK19	0.71775908
58	MAPK13	0.70930999
59	CSNK1G3	0.68916837
60	PRKCG	0.68660770
61	CDK3	0.68358835
62	CSNK1G2	0.66925206
63	AURKB	0.64804846
64	MAP4K2	0.62799350
65	ERBB2	0.62327900
66	MAP3K7	0.60181278
67	CSNK1A1L	0.58585779
68	ILK	0.57143638
69	SIK1	0.51087956
70	TSSK6	0.50439270
71	STK24	0.50171885
72	PRKCZ	0.47834611
73	UHMK1	0.47603487
74	CSNK1G1	0.47547669
75	MUSK	0.46828712
76	BRSK1	0.44996662
77	MAP2K2	0.44228486
78	TNIK	0.43678477
79	SRPK1	0.43139064
80	CCNB1	0.41378910
81	MAP3K10	0.41336125
82	DMPK	0.41134248
83	CAMK2G	0.39677494
84	RPS6KA4	0.39386797
85	CAMKK1	0.38602953
86	MARK2	0.38419636
87	GRK1	0.37896115
88	PRKDC	0.37686607
89	RPS6KA6	0.37415415
90	MET	0.36262390
91	STK11	0.36079052
92	BRAF	0.34444381
93	ROCK2	0.34271496
94	FGFR2	0.34103251
95	PLK2	0.33574862
96	MAP3K11	0.32263819
97	PTK2	0.32200803
98	AKT2	0.31785492
99	TAF1	0.31417643
100	PKN1	0.30121362

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Huntingtons disease_Homo sapiens_hsa05016	3.28508321
2	Ribosome_Homo sapiens_hsa03010	2.86117274
3	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.53069783
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.47274708
5	Basal cell carcinoma_Homo sapiens_hsa05217	2.35292039
6	Phenylalanine metabolism_Homo sapiens_hsa00360	2.32330662
7	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.21357938
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.16043540
9	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.13154495
10	Chemical carcinogenesis_Homo sapiens_hsa05204	1.94010245
11	Parkinsons disease_Homo sapiens_hsa05012	1.92492756
12	Tyrosine metabolism_Homo sapiens_hsa00350	1.91347503
13	Sulfur relay system_Homo sapiens_hsa04122	1.89931321
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.88860571
15	Steroid biosynthesis_Homo sapiens_hsa00100	1.85288069
16	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.73978023
17	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.66108120
18	Cardiac muscle contraction_Homo sapiens_hsa04260	1.63896010
19	Histidine metabolism_Homo sapiens_hsa00340	1.63601695
20	Protein export_Homo sapiens_hsa03060	1.61477093
21	Homologous recombination_Homo sapiens_hsa03440	1.58685278
22	Notch signaling pathway_Homo sapiens_hsa04330	1.57036580
23	Glutathione metabolism_Homo sapiens_hsa00480	1.55433200
24	Nucleotide excision repair_Homo sapiens_hsa03420	1.52951591
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.49762477
26	beta-Alanine metabolism_Homo sapiens_hsa00410	1.47623586
27	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.44794791
28	Hippo signaling pathway_Homo sapiens_hsa04390	1.34658789
29	Alzheimers disease_Homo sapiens_hsa05010	1.34515506
30	Nicotine addiction_Homo sapiens_hsa05033	1.33880271
31	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.30980195
32	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.26860412
33	RNA polymerase_Homo sapiens_hsa03020	1.26614418
34	Base excision repair_Homo sapiens_hsa03410	1.25296320
35	Axon guidance_Homo sapiens_hsa04360	1.21751756
36	Phototransduction_Homo sapiens_hsa04744	1.21019441
37	Butanoate metabolism_Homo sapiens_hsa00650	1.15679748
38	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.12063441
39	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.12048484
40	Spliceosome_Homo sapiens_hsa03040	1.10296514
41	Mismatch repair_Homo sapiens_hsa03430	1.09896621
42	Pyrimidine metabolism_Homo sapiens_hsa00240	1.09406803
43	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.06310582
44	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.06135421
45	DNA replication_Homo sapiens_hsa03030	1.04774618
46	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.03594719
47	Linoleic acid metabolism_Homo sapiens_hsa00591	1.01122075
48	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.95656654
49	Tight junction_Homo sapiens_hsa04530	0.94167773
50	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.93992896
51	Retinol metabolism_Homo sapiens_hsa00830	0.92338334
52	Cocaine addiction_Homo sapiens_hsa05030	0.88615298
53	Wnt signaling pathway_Homo sapiens_hsa04310	0.81201618
54	Alcoholism_Homo sapiens_hsa05034	0.79757692
55	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.77263165
56	Caffeine metabolism_Homo sapiens_hsa00232	0.75167182
57	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.74864039
58	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.74002819
59	Metabolic pathways_Homo sapiens_hsa01100	0.72469990
60	Melanogenesis_Homo sapiens_hsa04916	0.71656771
61	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.70733211
62	Folate biosynthesis_Homo sapiens_hsa00790	0.70370377
63	Selenocompound metabolism_Homo sapiens_hsa00450	0.70237345
64	Purine metabolism_Homo sapiens_hsa00230	0.69762166
65	Basal transcription factors_Homo sapiens_hsa03022	0.69647948
66	Taste transduction_Homo sapiens_hsa04742	0.69470066
67	Olfactory transduction_Homo sapiens_hsa04740	0.67839305
68	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.67263704
69	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.66610401
70	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.61642712
71	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.59915031
72	Peroxisome_Homo sapiens_hsa04146	0.56945111
73	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.54969419
74	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.54074499
75	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.53923292
76	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.51454314
77	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.51217856
78	Collecting duct acid secretion_Homo sapiens_hsa04966	0.51155856
79	Arginine and proline metabolism_Homo sapiens_hsa00330	0.50320856
80	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.49928251
81	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.47725889
82	mRNA surveillance pathway_Homo sapiens_hsa03015	0.46274511
83	Propanoate metabolism_Homo sapiens_hsa00640	0.45969502
84	RNA transport_Homo sapiens_hsa03013	0.45728337
85	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.45715104
86	Gap junction_Homo sapiens_hsa04540	0.44948119
87	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.44878177
88	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.44434221
89	GABAergic synapse_Homo sapiens_hsa04727	0.43737795
90	Pyruvate metabolism_Homo sapiens_hsa00620	0.43301707
91	Insulin secretion_Homo sapiens_hsa04911	0.42570253
92	Fatty acid degradation_Homo sapiens_hsa00071	0.42391314
93	Glutamatergic synapse_Homo sapiens_hsa04724	0.41632709
94	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.41302024
95	RNA degradation_Homo sapiens_hsa03018	0.40009205
96	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.39623527
97	Vibrio cholerae infection_Homo sapiens_hsa05110	0.37080700
98	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.36760372
99	Circadian entrainment_Homo sapiens_hsa04713	0.34534413
100	One carbon pool by folate_Homo sapiens_hsa00670	0.34003453

CCDC74B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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