CCDC78

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene contains two coiled-coil domains. The function of this gene is currently unknown. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)9.76293659
2left/right pattern formation (GO:0060972)8.98930576
3primary alcohol catabolic process (GO:0034310)7.77847853
4regulation of cilium movement (GO:0003352)7.18658281
5vitamin transmembrane transport (GO:0035461)7.09980422
6ventricular system development (GO:0021591)6.47525191
7ethanol metabolic process (GO:0006067)6.39344105
8left/right axis specification (GO:0070986)6.29165582
9microtubule bundle formation (GO:0001578)6.21936148
10diterpenoid biosynthetic process (GO:0016102)6.11215062
11lung epithelium development (GO:0060428)5.64104163
12intraciliary transport (GO:0042073)5.57566667
13tolerance induction (GO:0002507)5.50817292
14establishment of apical/basal cell polarity (GO:0035089)5.50523324
15cilium organization (GO:0044782)5.40158395
16pyrimidine-containing compound transmembrane transport (GO:0072531)5.38696925
17cilium assembly (GO:0042384)5.26039777
18one-carbon compound transport (GO:0019755)5.23868921
19response to xenobiotic stimulus (GO:0009410)5.04585296
20superoxide anion generation (GO:0042554)4.98703811
21negative regulation of T cell differentiation in thymus (GO:0033085)4.95974786
22sperm capacitation (GO:0048240)4.90698307
23negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.86350361
24glomerular epithelial cell development (GO:0072310)4.65855374
25negative regulation of immunoglobulin mediated immune response (GO:0002890)4.63827916
26negative regulation of B cell mediated immunity (GO:0002713)4.63827916
27establishment of monopolar cell polarity (GO:0061162)4.63644717
28establishment or maintenance of monopolar cell polarity (GO:0061339)4.63644717
29regulation of interleukin-5 production (GO:0032674)4.57865566
30ethanol oxidation (GO:0006069)4.55139848
31protein localization to cilium (GO:0061512)4.47150527
32microtubule-based movement (GO:0007018)4.37686494
33regulation of interleukin-13 production (GO:0032656)4.28948411
34regulation of germinal center formation (GO:0002634)4.26305391
35negative regulation of humoral immune response (GO:0002921)4.20405913
36regulation of microtubule-based movement (GO:0060632)4.14729497
37terpenoid biosynthetic process (GO:0016114)4.12431036
38positive regulation of tolerance induction (GO:0002645)4.11212763
39cellular component assembly involved in morphogenesis (GO:0010927)4.09033313
40retinoic acid metabolic process (GO:0042573)4.02336169
41cell projection assembly (GO:0030031)3.90278831
42regulation of nuclear cell cycle DNA replication (GO:0033262)3.81394338
43cytoplasmic microtubule organization (GO:0031122)3.71673673
44cilium morphogenesis (GO:0060271)3.67747595
45nucleoside diphosphate phosphorylation (GO:0006165)3.67696516
46detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.66050973
47negative regulation of myoblast differentiation (GO:0045662)3.48165087
48O-glycan processing (GO:0016266)3.41635178
49regulation of timing of cell differentiation (GO:0048505)3.39670097
50microtubule polymerization or depolymerization (GO:0031109)3.38490872
51establishment of planar polarity (GO:0001736)3.37899696
52establishment of tissue polarity (GO:0007164)3.37899696
53negative regulation of inclusion body assembly (GO:0090084)3.35156598
54mesenchymal cell differentiation involved in kidney development (GO:0072161)3.33962955
55mesenchymal cell differentiation involved in renal system development (GO:2001012)3.33962955
56bone trabecula formation (GO:0060346)3.33699247
57cell differentiation involved in metanephros development (GO:0072202)3.26134326
58primary alcohol metabolic process (GO:0034308)3.24303268
59positive regulation of smoothened signaling pathway (GO:0045880)3.23862020
60multicellular organismal water homeostasis (GO:0050891)3.23204622
61exogenous drug catabolic process (GO:0042738)3.20870877
62retinol metabolic process (GO:0042572)3.19246962
63negative regulation of DNA-dependent DNA replication (GO:2000104)3.16095522
64regulation of microtubule depolymerization (GO:0031114)3.15515580
65glutathione derivative metabolic process (GO:1901685)3.13725158
66glutathione derivative biosynthetic process (GO:1901687)3.13725158
67androgen biosynthetic process (GO:0006702)3.11217982
68presynaptic membrane assembly (GO:0097105)3.09297587
69regulation of tolerance induction (GO:0002643)3.08342529
70lateral ventricle development (GO:0021670)3.06956790
71hydrogen peroxide biosynthetic process (GO:0050665)3.06014668
72postsynaptic membrane organization (GO:0001941)3.05398424
73NAD biosynthetic process (GO:0009435)3.04803633
74regulation of development, heterochronic (GO:0040034)3.04528368
75reflex (GO:0060004)3.04455843
76DNA integration (GO:0015074)3.03802645
77hematopoietic stem cell proliferation (GO:0071425)3.03453651
78positive regulation of hair follicle development (GO:0051798)3.02027544
79positive regulation of hair cycle (GO:0042635)3.02027544
80axonemal dynein complex assembly (GO:0070286)21.6400420
81response to peptidoglycan (GO:0032494)2.92960073
82phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.92203201
83omega-hydroxylase P450 pathway (GO:0097267)2.91885155
84regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.91834804
85detection of bacterium (GO:0016045)2.91663268
86detection of other organism (GO:0098543)2.90661979
87dendritic cell chemotaxis (GO:0002407)2.89804782
88dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.87703789
89presynaptic membrane organization (GO:0097090)2.86510255
90glomerulus development (GO:0032835)2.84511981
91cyclic nucleotide catabolic process (GO:0009214)2.84202228
92positive regulation of cellular amide metabolic process (GO:0034250)2.83661514
93carnitine metabolic process (GO:0009437)2.83612046
94phosphatidylcholine biosynthetic process (GO:0006656)2.82699389
95cAMP catabolic process (GO:0006198)2.80881149
96DNA ligation (GO:0006266)2.80811044
97facial nerve structural organization (GO:0021612)2.79070424
98superoxide metabolic process (GO:0006801)2.78628414
99polyketide metabolic process (GO:0030638)2.77668120
100doxorubicin metabolic process (GO:0044598)2.77668120
101daunorubicin metabolic process (GO:0044597)2.77668120
102negative regulation of mast cell activation (GO:0033004)2.77435183
103hypotonic response (GO:0006971)2.76810193
104regulation of RIG-I signaling pathway (GO:0039535)2.75418677
105apical protein localization (GO:0045176)2.75268686
106GPI anchor biosynthetic process (GO:0006506)2.75266504
107ear development (GO:0043583)2.74157371
108reactive oxygen species biosynthetic process (GO:1903409)2.72073953
109iron ion import (GO:0097286)2.71670720
110regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.71543372
111female gonad development (GO:0008585)2.71525624
112glutathione biosynthetic process (GO:0006750)2.68341248
113inner ear receptor cell differentiation (GO:0060113)2.67868962
114cellular response to interleukin-15 (GO:0071350)2.67684884
115regulation of response to osmotic stress (GO:0047484)2.66864661
116developmental pigmentation (GO:0048066)2.66215615
117water homeostasis (GO:0030104)2.66073835
118microtubule depolymerization (GO:0007019)2.65958998
119RNA-dependent DNA replication (GO:0006278)2.64955818
120phosphatidylethanolamine biosynthetic process (GO:0006646)2.64564675
121positive regulation of uterine smooth muscle contraction (GO:0070474)2.64382535
122progesterone metabolic process (GO:0042448)2.64052617
123protein heterotetramerization (GO:0051290)2.63679516
124regulation of autophagic vacuole assembly (GO:2000785)2.63356428
125G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.63078097
126calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.62495396
127regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.61678113
128regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.61626313
129startle response (GO:0001964)2.60591376
130regulation of non-canonical Wnt signaling pathway (GO:2000050)2.59961990
131negative regulation of microtubule depolymerization (GO:0007026)2.59531760
132oligosaccharide biosynthetic process (GO:0009312)2.59279845
133adenosine metabolic process (GO:0046085)2.58772054
134establishment or maintenance of bipolar cell polarity (GO:0061245)2.58239711
135establishment or maintenance of apical/basal cell polarity (GO:0035088)2.58239711
136renal absorption (GO:0070293)2.58193265
137preassembly of GPI anchor in ER membrane (GO:0016254)2.57926984
138excretion (GO:0007588)2.57269056
139regulation of male gonad development (GO:2000018)2.57252863
140aldehyde catabolic process (GO:0046185)2.57068486
141DNA methylation involved in gamete generation (GO:0043046)2.57034380
142sialylation (GO:0097503)2.54928202
143sperm motility (GO:0030317)2.54695363
144extracellular negative regulation of signal transduction (GO:1900116)2.54562718
145extracellular regulation of signal transduction (GO:1900115)2.54562718
146negative regulation of leukocyte chemotaxis (GO:0002689)2.54448972
147* microtubule-based process (GO:0007017)2.53561176
148amino sugar catabolic process (GO:0046348)2.52872282
149glutathione metabolic process (GO:0006749)2.51868608
150regulation of interleukin-8 secretion (GO:2000482)2.50436466
151negative regulation of execution phase of apoptosis (GO:1900118)2.50009432
152oligosaccharide catabolic process (GO:0009313)2.49034803
153carnitine transmembrane transport (GO:1902603)2.48754970
154regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.48264346
155lateral sprouting from an epithelium (GO:0060601)2.48263535
156positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.48057216
157positive regulation of cell cycle G2/M phase transition (GO:1902751)2.48057216
158lymphoid progenitor cell differentiation (GO:0002320)2.47625546
159regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.47126786
160G-protein coupled receptor internalization (GO:0002031)2.46052023
161nucleoside diphosphate catabolic process (GO:0009134)2.45910005
162glycosphingolipid catabolic process (GO:0046479)2.45908243
163regulation of pigment cell differentiation (GO:0050932)2.45184684
164regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.45181534
165telomere maintenance via telomerase (GO:0007004)2.44346151
166hydrogen peroxide catabolic process (GO:0042744)2.44248480
167interferon-gamma production (GO:0032609)2.43887286
168viral genome replication (GO:0019079)2.43331323
169detection of calcium ion (GO:0005513)2.42477027
170auditory receptor cell differentiation (GO:0042491)2.41692863
171regulation of activation of Janus kinase activity (GO:0010533)2.41146016
172positive regulation of protein homodimerization activity (GO:0090073)2.40688189
173positive regulation of interleukin-1 beta secretion (GO:0050718)2.40513025
174dendritic cell migration (GO:0036336)2.40138348
175tRNA methylation (GO:0030488)2.39450747
176mannosylation (GO:0097502)2.38453729
177GPI anchor metabolic process (GO:0006505)2.38390560
178generation of neurons (GO:0048699)2.37945906
179ceramide catabolic process (GO:0046514)2.37841716
180ganglion development (GO:0061548)2.37716678
181cytochrome complex assembly (GO:0017004)2.34946961
182synapsis (GO:0007129)2.34592748
183L-amino acid import (GO:0043092)2.34186435
184positive regulation of calcium ion import (GO:0090280)2.33910047
185cellular anion homeostasis (GO:0030002)2.33143285
186negative regulation of telomere maintenance (GO:0032205)2.31979384
187cellular response to gamma radiation (GO:0071480)2.31185644
188androgen metabolic process (GO:0008209)2.30309280
189cilium or flagellum-dependent cell motility (GO:0001539)2.29929109
190regulation of platelet aggregation (GO:0090330)2.29665950
191opioid receptor signaling pathway (GO:0038003)2.29637990
192C-terminal protein lipidation (GO:0006501)2.29290308
193regulation of antigen processing and presentation (GO:0002577)2.28370940
194DNA deamination (GO:0045006)2.28340756
195motile cilium assembly (GO:0044458)15.1372011
196cilium movement (GO:0003341)14.9303380
197epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)13.3693948
198epithelial cilium movement (GO:0003351)12.7551961

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.04533986
2GBX2_23144817_ChIP-Seq_PC3_Human3.82481705
3EZH2_22144423_ChIP-Seq_EOC_Human3.59410046
4PCGF2_27294783_Chip-Seq_ESCs_Mouse3.07965525
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.98117437
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.94686272
7DROSHA_22980978_ChIP-Seq_HELA_Human2.79037189
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.70307036
9SUZ12_27294783_Chip-Seq_NPCs_Mouse2.66271376
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.64964758
11PCGF2_27294783_Chip-Seq_NPCs_Mouse2.61187323
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.57955050
13SMC4_20622854_ChIP-Seq_HELA_Human2.57593188
14BMI1_23680149_ChIP-Seq_NPCS_Mouse2.56727727
15LXR_22292898_ChIP-Seq_THP-1_Human2.56571996
16RACK7_27058665_Chip-Seq_MCF-7_Human2.51578258
17NFE2_27457419_Chip-Seq_LIVER_Mouse2.50294611
18TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.49641449
19CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.46852733
20CBX2_27304074_Chip-Seq_ESCs_Mouse2.43237333
21RUNX1_27514584_Chip-Seq_MCF-7_Human2.42599041
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.41303263
23* P68_20966046_ChIP-Seq_HELA_Human2.36053789
24FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.26184523
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.25762366
26ESR1_21235772_ChIP-Seq_MCF-7_Human2.25433184
27EZH2_27294783_Chip-Seq_NPCs_Mouse2.19313147
28STAT6_21828071_ChIP-Seq_BEAS2B_Human2.12143533
29ELF1_20517297_ChIP-Seq_JURKAT_Human2.10177272
30EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse2.09386843
31ESR1_20079471_ChIP-ChIP_T-47D_Human2.06985631
32VDR_21846776_ChIP-Seq_THP-1_Human2.03187133
33STAT3_18555785_Chip-Seq_ESCs_Mouse2.01738046
34SUZ12_18555785_Chip-Seq_ESCs_Mouse1.97482478
35NMYC_18555785_Chip-Seq_ESCs_Mouse1.96561555
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.95259936
37P53_22387025_ChIP-Seq_ESCs_Mouse1.93187793
38IRF1_19129219_ChIP-ChIP_H3396_Human1.92687527
39NANOG_18555785_Chip-Seq_ESCs_Mouse1.91480134
40CREB1_26743006_Chip-Seq_LNCaP_Human1.90643593
41EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.90600769
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.89802814
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.89612447
44JARID2_20064375_ChIP-Seq_MESCs_Mouse1.88867241
45E2F1_18555785_Chip-Seq_ESCs_Mouse1.88291833
46* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.87381534
47TP63_17297297_ChIP-ChIP_HaCaT_Human1.87008861
48CTCF_27219007_Chip-Seq_Bcells_Human1.86837099
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.84790518
50TP63_22573176_ChIP-Seq_HFKS_Human1.83736972
51SOX2_27498859_Chip-Seq_STOMACH_Mouse1.83331730
52CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.80475680
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79559756
54RUNX1_27457419_Chip-Seq_LIVER_Mouse1.78034348
55PHF8_20622854_ChIP-Seq_HELA_Human1.77654881
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.77181434
57KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.77179602
58P300_18555785_Chip-Seq_ESCs_Mouse1.77151618
59RARG_19884340_ChIP-ChIP_MEFs_Mouse1.77128645
60CMYC_18555785_Chip-Seq_ESCs_Mouse1.75629989
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.75343736
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.74931625
63RNF2_27304074_Chip-Seq_NSC_Mouse1.73777060
64SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.73225400
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.73158925
66SOX2_18555785_Chip-Seq_ESCs_Mouse1.72178485
67P63_26484246_Chip-Seq_KERATINOCYTES_Human1.71871976
68ZFX_18555785_Chip-Seq_ESCs_Mouse1.71654105
69PU1_27457419_Chip-Seq_LIVER_Mouse1.69300188
70OCT4_18555785_Chip-Seq_ESCs_Mouse1.69077527
71TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68528713
72KLF4_18555785_Chip-Seq_ESCs_Mouse1.68371729
73BCOR_27268052_Chip-Seq_Bcells_Human1.67129679
74SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.66670030
75ZNF263_19887448_ChIP-Seq_K562_Human1.66263856
76SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.64089230
77SA1_27219007_Chip-Seq_ERYTHROID_Human1.63886972
78KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63016505
79E2F1_20622854_ChIP-Seq_HELA_Human1.61950154
80ESRRB_18555785_Chip-Seq_ESCs_Mouse1.61352316
81SMAD1_18555785_Chip-Seq_ESCs_Mouse1.59317131
82EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57671878
83TAF15_26573619_Chip-Seq_HEK293_Human1.57227677
84CTCF_18555785_Chip-Seq_ESCs_Mouse1.56604947
85BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.56104888
86JARID2_20075857_ChIP-Seq_MESCs_Mouse1.54064805
87ELF1_17652178_ChIP-ChIP_JURKAT_Human1.53172538
88YY1_22570637_ChIP-Seq_MALME-3M_Human1.53040780
89POU5F1_16153702_ChIP-ChIP_HESCs_Human1.51400055
90ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.50713330
91CRX_20693478_ChIP-Seq_RETINA_Mouse1.50557557
92TAL1_26923725_Chip-Seq_HPCs_Mouse1.50402614
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50134995
94HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.49060078
95STAT1_20625510_ChIP-Seq_HELA_Human1.48604436
96SRY_22984422_ChIP-ChIP_TESTIS_Rat1.48240565
97KLF5_25053715_ChIP-Seq_YYC3_Human1.47035134
98SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46552697
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45838397
100* BCL6_27268052_Chip-Seq_Bcells_Human1.45790460
101EZH2_27294783_Chip-Seq_ESCs_Mouse1.45466556
102P300_19829295_ChIP-Seq_ESCs_Human1.44099548
103RNF2_18974828_ChIP-Seq_MESCs_Mouse1.44031758
104EZH2_18974828_ChIP-Seq_MESCs_Mouse1.44031758
105OCT4_21477851_ChIP-Seq_ESCs_Mouse1.43626760
106PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.43506358
107* CTCF_20526341_ChIP-Seq_ESCs_Human1.43289417
108TDRD3_21172665_ChIP-Seq_MCF-7_Human1.41656233
109SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.41516482
110CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.40246626
111GATA1_19941826_ChIP-Seq_K562_Human1.39728573
112RARB_24833708_ChIP-Seq_LIVER_Mouse1.39637687
113PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38191072
114RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38140498
115CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36417149
116DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.35542113
117SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.35517770
118SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.35436773
119BP1_19119308_ChIP-ChIP_Hs578T_Human1.35381120
120* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.35244465
121RAD21_21589869_ChIP-Seq_MESCs_Mouse1.34843615
122VDR_24763502_ChIP-Seq_THP-1_Human1.31991756
123SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.30371259
124PIAS1_25552417_ChIP-Seq_VCAP_Human1.30109065
125MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29967084
126* MAF_26560356_Chip-Seq_TH1_Human1.29587056
127TP53_22127205_ChIP-Seq_IMR90_Human1.29350393
128LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28646479
129SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28411000
130LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28394375
131FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.28143007
132TP63_19390658_ChIP-ChIP_HaCaT_Human1.27983288
133VDR_22108803_ChIP-Seq_LS180_Human1.27936264
134SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25721034
135P300_27268052_Chip-Seq_Bcells_Human1.23776738
136IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.23628687
137HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.22102245
138MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21245243
139AHR_22903824_ChIP-Seq_MCF-7_Human1.20785024
140SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20771699
141FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.20726258
142* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20523828
143SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18540777
144CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18399193
145CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18060412
146RNF2_27304074_Chip-Seq_ESCs_Mouse1.18003668
147CTCF_27219007_Chip-Seq_ERYTHROID_Human1.17312707
148SOX9_24532713_ChIP-Seq_HFSC_Mouse1.17046096
149STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17039585
150IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.16533382
151CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16406393
152CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.16262634
153SA1_27219007_Chip-Seq_Bcells_Human1.16041654
154KDM2B_26808549_Chip-Seq_REH_Human1.15903995
155IGF1R_20145208_ChIP-Seq_DFB_Human1.14559296
156ELK3_25401928_ChIP-Seq_HUVEC_Human1.13466771
157TET1_21451524_ChIP-Seq_MESCs_Mouse1.12995397
158ER_23166858_ChIP-Seq_MCF-7_Human1.12763792
159SMAD_19615063_ChIP-ChIP_OVARY_Human1.12722408
160NOTCH1_21737748_ChIP-Seq_TLL_Human1.12130557
161IRF8_21731497_ChIP-ChIP_J774_Mouse1.11341901
162PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11205400
163SMAD3_21741376_ChIP-Seq_EPCs_Human1.10922251
164FLI1_21867929_ChIP-Seq_CD8_Mouse1.10863966
165CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10540261
166SMAD4_21799915_ChIP-Seq_A2780_Human1.10464103
167TCF7_22412390_ChIP-Seq_EML_Mouse1.10072069
168* RARA_24833708_ChIP-Seq_LIVER_Mouse1.09977683
169* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09684813
170NCOR1_26117541_ChIP-Seq_K562_Human1.09583473
171EWS_26573619_Chip-Seq_HEK293_Human1.08976198
172ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08319049
173STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08300993
174MAF_26560356_Chip-Seq_TH2_Human1.07568849
175KAP1_22055183_ChIP-Seq_ESCs_Mouse1.07156054
176SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.05612576
177UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04314193
178THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03839815
179AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.03513340
180MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.03022500
181SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.02478487
182RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.01286859
183TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00942595
184SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.00653842
185FUS_26573619_Chip-Seq_HEK293_Human1.00183413
186KDM2B_26808549_Chip-Seq_K562_Human0.99963480
187GATA3_24758297_ChIP-Seq_MCF-7_Human0.99364408
188SOX2_20726797_ChIP-Seq_SW620_Human0.98566007
189RUNX2_22187159_ChIP-Seq_PCA_Human0.98451330
190P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.97082021
191STAT1_17558387_ChIP-Seq_HELA_Human0.96361241
192CTCF_21964334_Chip-Seq_Bcells_Human0.96248731
193SOX2_21211035_ChIP-Seq_LN229_Human0.96229622
194UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96014578
195CDX2_20551321_ChIP-Seq_CACO-2_Human0.95095807
196TCF4_23295773_ChIP-Seq_U87_Human0.94718928
197KDM2B_26808549_Chip-Seq_DND41_Human0.91545407
198STAT3_23295773_ChIP-Seq_U87_Human0.90914409
199MYC_27129775_Chip-Seq_CORNEA_Mouse0.90239022

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok7.25896333
2MP0002653_abnormal_ependyma_morphology5.65872844
3MP0001188_hyperpigmentation4.79399572
4MP0004043_abnormal_pH_regulation3.98381704
5MP0009780_abnormal_chondrocyte_physiolo3.65029986
6MP0002102_abnormal_ear_morphology3.57895378
7MP0006292_abnormal_olfactory_placode3.48891992
8MP0000566_synostosis3.47455179
9MP0004133_heterotaxia3.16907892
10MP0003136_yellow_coat_color2.98078233
11MP0005623_abnormal_meninges_morphology2.96772724
12MP0005083_abnormal_biliary_tract2.77131426
13MP0005171_absent_coat_pigmentation2.63060908
14MP0004381_abnormal_hair_follicle2.42055828
15MP0005409_darkened_coat_color2.35629477
16MP0002277_abnormal_respiratory_mucosa2.33076691
17MP0000015_abnormal_ear_pigmentation2.28236018
18MP0005645_abnormal_hypothalamus_physiol2.13949033
19MP0002638_abnormal_pupillary_reflex2.11528746
20MP0004019_abnormal_vitamin_homeostasis2.06766463
21MP0010234_abnormal_vibrissa_follicle2.06434267
22MP0001765_abnormal_ion_homeostasis2.02425803
23MP0005377_hearing/vestibular/ear_phenot2.02223113
24MP0003878_abnormal_ear_physiology2.02223113
25MP0003941_abnormal_skin_development2.00278735
26MP0005174_abnormal_tail_pigmentation1.98349970
27MP0000383_abnormal_hair_follicle1.96780834
28MP0010386_abnormal_urinary_bladder1.95700540
29MP0003656_abnormal_erythrocyte_physiolo1.92779439
30MP0002168_other_aberrant_phenotype1.85958484
31MP0008260_abnormal_autophagy1.84074809
32MP0004782_abnormal_surfactant_physiolog1.81246091
33MP0010678_abnormal_skin_adnexa1.80574808
34MP0001986_abnormal_taste_sensitivity1.75419344
35MP0003880_abnormal_central_pattern1.73495070
36MP0009785_altered_susceptibility_to1.71416382
37MP0005646_abnormal_pituitary_gland1.68477030
38MP0003453_abnormal_keratinocyte_physiol1.66465734
39MP0005671_abnormal_response_to1.64748618
40MP0006276_abnormal_autonomic_nervous1.64590263
41MP0008995_early_reproductive_senescence1.64184424
42MP0002876_abnormal_thyroid_physiology1.62292050
43MP0003724_increased_susceptibility_to1.62211112
44MP0004742_abnormal_vestibular_system1.61797873
45MP0008058_abnormal_DNA_repair1.58820230
46MP0000372_irregular_coat_pigmentation1.56775629
47MP0002132_abnormal_respiratory_system1.56218038
48MP0000026_abnormal_inner_ear1.55840395
49MP0002148_abnormal_hypersensitivity_rea1.55293613
50MP0002909_abnormal_adrenal_gland1.52336390
51MP0002282_abnormal_trachea_morphology1.52082029
52MP0000678_abnormal_parathyroid_gland1.51356141
53MP0003195_calcinosis1.50513306
54MP0001835_abnormal_antigen_presentation1.46756165
55MP0001849_ear_inflammation1.45580447
56MP0005075_abnormal_melanosome_morpholog1.42923400
57MP0010155_abnormal_intestine_physiology1.42600904
58MP0003303_peritoneal_inflammation1.41450676
59MP0001486_abnormal_startle_reflex1.37885054
60MP0001502_abnormal_circadian_rhythm1.36920376
61MP0009379_abnormal_foot_pigmentation1.34722784
62MP0004264_abnormal_extraembryonic_tissu1.34653095
63MP0005379_endocrine/exocrine_gland_phen1.31574290
64MP0004142_abnormal_muscle_tone1.31316144
65MP0002095_abnormal_skin_pigmentation1.30198639
66MP0006072_abnormal_retinal_apoptosis1.29788041
67MP0008057_abnormal_DNA_replication1.21626451
68MP0002938_white_spotting1.19362482
69MP0001963_abnormal_hearing_physiology1.18848146
70MP0005076_abnormal_cell_differentiation1.18535310
71MP0003938_abnormal_ear_development1.17748360
72MP0002736_abnormal_nociception_after1.17689021
73MP0001790_abnormal_immune_system1.16967290
74MP0005387_immune_system_phenotype1.16967290
75MP0002163_abnormal_gland_morphology1.16611852
76MP0009697_abnormal_copulation1.14626419
77MP0003787_abnormal_imprinting1.13921770
78MP0003763_abnormal_thymus_physiology1.12338184
79MP0005253_abnormal_eye_physiology1.11819081
80MP0008789_abnormal_olfactory_epithelium1.09991344
81MP0001186_pigmentation_phenotype1.06855685
82MP0005636_abnormal_mineral_homeostasis1.06678819
83MP0002419_abnormal_innate_immunity1.05949814
84MP0000569_abnormal_digit_pigmentation1.04756841
85MP0005395_other_phenotype1.04710803
86MP0003786_premature_aging1.04417845
87MP0000049_abnormal_middle_ear1.04219387
88MP0005165_increased_susceptibility_to1.04167239
89MP0001968_abnormal_touch/_nociception1.03771145
90MP0005000_abnormal_immune_tolerance1.03207737
91MP0009764_decreased_sensitivity_to1.03079687
92MP0009643_abnormal_urine_homeostasis1.02860863
93MP0010030_abnormal_orbit_morphology1.02407674
94MP0005551_abnormal_eye_electrophysiolog1.01687694
95MP0003705_abnormal_hypodermis_morpholog0.99883970
96MP0002751_abnormal_autonomic_nervous0.99882288
97MP0005025_abnormal_response_to0.99791378
98MP0000858_altered_metastatic_potential0.99707852
99MP0005248_abnormal_Harderian_gland0.97919135
100MP0000631_abnormal_neuroendocrine_gland0.97917444
101MP0005423_abnormal_somatic_nervous0.97840204
102MP0005220_abnormal_exocrine_pancreas0.97836626
103MP0000613_abnormal_salivary_gland0.96308648
104MP0005365_abnormal_bile_salt0.96210090
105MP0001919_abnormal_reproductive_system0.94574403
106MP0002557_abnormal_social/conspecific_i0.94349784
107MP0002136_abnormal_kidney_physiology0.93281537
108MP0005394_taste/olfaction_phenotype0.92211836
109MP0005499_abnormal_olfactory_system0.92211836
110MP0000490_abnormal_crypts_of0.92064804
111MP0000681_abnormal_thyroid_gland0.90966907
112MP0005257_abnormal_intraocular_pressure0.90507885
113MP0001984_abnormal_olfaction0.90064008
114MP0001905_abnormal_dopamine_level0.87576620
115MP0002249_abnormal_larynx_morphology0.87169926
116MP0005410_abnormal_fertilization0.86080902
117MP0002160_abnormal_reproductive_system0.85985933
118MP0001485_abnormal_pinna_reflex0.85420387
119MP0002098_abnormal_vibrissa_morphology0.84837095
120MP0005310_abnormal_salivary_gland0.83521380
121MP0002723_abnormal_immune_serum0.82590440
122MP0000579_abnormal_nail_morphology0.82257909
123MP0002177_abnormal_outer_ear0.81063924
124MP0002067_abnormal_sensory_capabilities0.80607566
125MP0000465_gastrointestinal_hemorrhage0.80360371
126MP0000467_abnormal_esophagus_morphology0.79828814
127MP0002452_abnormal_antigen_presenting0.78118100
128MP0002752_abnormal_somatic_nervous0.78063335
129MP0002734_abnormal_mechanical_nocicepti0.77941034
130MP0002735_abnormal_chemical_nociception0.77871828
131MP0001819_abnormal_immune_cell0.76793801
132MP0002420_abnormal_adaptive_immunity0.75935288
133MP0003718_maternal_effect0.73300151
134MP0002933_joint_inflammation0.72923491
135MP0002796_impaired_skin_barrier0.72526666
136MP0005389_reproductive_system_phenotype0.72094172
137MP0005408_hypopigmentation0.71641191
138MP0001800_abnormal_humoral_immune0.70531575
139MP0001664_abnormal_digestion0.69987005
140MP0001346_abnormal_lacrimal_gland0.69714067
141MP0009745_abnormal_behavioral_response0.69195917
142MP0002075_abnormal_coat/hair_pigmentati0.68933699
143MP0002405_respiratory_system_inflammati0.67746159
144MP0001756_abnormal_urination0.66659333
145MP0001270_distended_abdomen0.61700037
146MP0001929_abnormal_gametogenesis0.57332760
147MP0005501_abnormal_skin_physiology0.56916335
148MP0002233_abnormal_nose_morphology0.56249328
149MP0003806_abnormal_nucleotide_metabolis0.55675827
150MP0002896_abnormal_bone_mineralization0.52867558
151MP0003698_abnormal_male_reproductive0.52553298
152MP0005058_abnormal_lysosome_morphology0.51644771
153MP0001944_abnormal_pancreas_morphology0.51032739
154MP0000751_myopathy0.50124754
155MP0005164_abnormal_response_to0.49951222
156MP0001663_abnormal_digestive_system0.49630757
157MP0005023_abnormal_wound_healing0.49425635
158MP0003866_abnormal_defecation0.47953984
159MP0000477_abnormal_intestine_morphology0.46117901
160MP0001873_stomach_inflammation0.45537590
161MP0010771_integument_phenotype0.45386177
162MP0002116_abnormal_craniofacial_bone0.45028300
163MP0000358_abnormal_cell_content/0.44961770
164MP0002822_catalepsy0.43665587
165MP0001324_abnormal_eye_pigmentation0.43439946
166MP0004883_abnormal_blood_vessel0.41660782
167MP0003191_abnormal_cellular_cholesterol0.41569098
168MP0009278_abnormal_bone_marrow0.41138220
169MP0009384_cardiac_valve_regurgitation0.40916073
170MP0004947_skin_inflammation0.40853618
171MP0009703_decreased_birth_body0.40738902
172MP0002135_abnormal_kidney_morphology0.40379088

Predicted human phenotypes

RankGene SetZ-score
1Chronic bronchitis (HP:0004469)7.93545594
2Bronchiectasis (HP:0002110)7.39899872
3Nasal polyposis (HP:0100582)7.12677303
4Abnormality of the nasal mucosa (HP:0000433)5.92655385
5Chromosomal breakage induced by crosslinking agents (HP:0003221)5.13815887
6Male infertility (HP:0003251)4.48280114
7Recurrent sinusitis (HP:0011108)4.45075656
8Infertility (HP:0000789)4.43313488
9Chromsome breakage (HP:0040012)4.38666474
10Bronchitis (HP:0012387)4.31289911
11Split foot (HP:0001839)4.11091491
12Recurrent otitis media (HP:0000403)4.01057195
13Severe visual impairment (HP:0001141)3.98682882
14Chronic sinusitis (HP:0011109)3.94361310
15Occipital encephalocele (HP:0002085)3.43063557
16Atelectasis (HP:0100750)3.40732604
17Type I transferrin isoform profile (HP:0003642)3.40581157
18Optic neuritis (HP:0100653)3.14909656
19Retrobulbar optic neuritis (HP:0100654)3.14909656
20Hypothermia (HP:0002045)3.12243890
21Reduced antithrombin III activity (HP:0001976)3.10187872
22Oligodactyly (hands) (HP:0001180)3.05703843
23Duplicated collecting system (HP:0000081)3.03746755
24Chronic otitis media (HP:0000389)2.97677221
25Hyperactive renin-angiotensin system (HP:0000841)2.96740674
26Pendular nystagmus (HP:0012043)2.96648908
27Abnormality of the renal collecting system (HP:0004742)2.90462486
28True hermaphroditism (HP:0010459)2.88574568
29Congenital sensorineural hearing impairment (HP:0008527)2.85955875
30Abnormality of the preputium (HP:0100587)2.66639794
31Prostate neoplasm (HP:0100787)2.64013124
32Aplasia/Hypoplasia of the fovea (HP:0008060)2.59392898
33Hypoplasia of the fovea (HP:0007750)2.59392898
34Cystic liver disease (HP:0006706)2.57366135
35Septo-optic dysplasia (HP:0100842)2.51093610
36Hypomagnesemia (HP:0002917)2.51003250
37Clubbing of toes (HP:0100760)2.49476965
38Type 2 muscle fiber atrophy (HP:0003554)2.48248278
39Aplasia/Hypoplasia of the uvula (HP:0010293)2.47016131
40Meckel diverticulum (HP:0002245)2.46782561
41Orchitis (HP:0100796)2.45855567
42Febrile seizures (HP:0002373)2.45556186
43White forelock (HP:0002211)2.43592213
44Molar tooth sign on MRI (HP:0002419)2.38894148
45Abnormality of midbrain morphology (HP:0002418)2.38894148
46Nephronophthisis (HP:0000090)2.38617359
47Abnormality of the ileum (HP:0001549)2.35849336
48Patchy hypopigmentation of hair (HP:0011365)2.35128010
49Recurrent cutaneous fungal infections (HP:0011370)2.34488040
50Chronic mucocutaneous candidiasis (HP:0002728)2.34488040
51Dynein arm defect of respiratory motile cilia (HP:0012255)2.33583390
52Absent/shortened dynein arms (HP:0200106)2.33583390
53Abnormality of magnesium homeostasis (HP:0004921)2.33395920
54Pancreatic fibrosis (HP:0100732)2.26595715
55Abnormal protein glycosylation (HP:0012346)2.26107772
56Abnormal glycosylation (HP:0012345)2.26107772
57Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.26107772
58Abnormal protein N-linked glycosylation (HP:0012347)2.26107772
59Chronic hepatic failure (HP:0100626)2.24376719
60Optic nerve hypoplasia (HP:0000609)2.22802040
61Absent hand (HP:0004050)2.22266745
62Alveolar cell carcinoma (HP:0006519)2.22047583
63Medial flaring of the eyebrow (HP:0010747)2.21474668
64Bell-shaped thorax (HP:0001591)2.20709107
65Abnormal ciliary motility (HP:0012262)2.19089597
66Abnormal delayed hypersensitivity skin test (HP:0002963)2.18713160
67Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.16629774
68Osteomalacia (HP:0002749)2.15451618
69Chronic obstructive pulmonary disease (HP:0006510)2.14114667
70Obstructive lung disease (HP:0006536)2.14114667
71Abnormality of DNA repair (HP:0003254)2.13335899
72Tubulointerstitial nephritis (HP:0001970)2.12019222
73Meningitis (HP:0001287)2.11804612
74Myositis (HP:0100614)2.11689368
75Male pseudohermaphroditism (HP:0000037)2.10471520
76Abnormality of chromosome stability (HP:0003220)2.06881972
77Renal cortical cysts (HP:0000803)2.06720891
78Tetany (HP:0001281)2.06499887
79Conical tooth (HP:0000698)2.05549042
80Pancreatic cysts (HP:0001737)2.04374255
81Decreased central vision (HP:0007663)2.03912408
82Abnormality of the fovea (HP:0000493)2.01788851
83Preaxial hand polydactyly (HP:0001177)2.01559111
84Recurrent abscess formation (HP:0002722)2.00330836
85Rhinitis (HP:0012384)10.0459080
86Median cleft lip (HP:0000161)1.99038805
87Basal ganglia calcification (HP:0002135)1.98750285
88Increased corneal curvature (HP:0100692)1.98491467
89Keratoconus (HP:0000563)1.98491467
90Abnormal respiratory epithelium morphology (HP:0012253)1.98415836
91Abnormal respiratory motile cilium morphology (HP:0005938)1.98415836
92Absent frontal sinuses (HP:0002688)1.96508165
93Congenital stationary night blindness (HP:0007642)1.95902192
94Upper limb muscle weakness (HP:0003484)1.95766314
95Postaxial foot polydactyly (HP:0001830)1.95294713
96Absent rod-and cone-mediated responses on ERG (HP:0007688)1.94588542
97Decreased circulating renin level (HP:0003351)1.94256891
98Intestinal atresia (HP:0011100)1.93636246
99Cheilitis (HP:0100825)1.91521656
100Panhypogammaglobulinemia (HP:0003139)1.90375079
101Attenuation of retinal blood vessels (HP:0007843)1.90122864
102Abnormality of macular pigmentation (HP:0008002)1.89073579
103Muscle fiber atrophy (HP:0100295)1.89008128
104Abnormality of the prostate (HP:0008775)1.86353479
105Increased IgM level (HP:0003496)1.86330529
106Oligodactyly (HP:0012165)1.85839269
107Absent septum pellucidum (HP:0001331)1.85726752
108Congenital hepatic fibrosis (HP:0002612)1.83974928
109Severe combined immunodeficiency (HP:0004430)1.83434697
110Abnormality of the septum pellucidum (HP:0007375)1.83092378
111Nephrogenic diabetes insipidus (HP:0009806)1.82952754
112Abnormality of calcium-phosphate metabolism (HP:0100530)1.82771048
113Recurrent bronchitis (HP:0002837)1.82239130
114Renal salt wasting (HP:0000127)1.82183244
115Aplasia cutis congenita (HP:0001057)1.80375912
116Prolonged neonatal jaundice (HP:0006579)1.79408772
117Abnormality of the renal medulla (HP:0100957)1.78486413
118Nonprogressive disorder (HP:0003680)1.75699817
119Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.75346649
120Neoplasm of the tracheobronchial system (HP:0100552)1.74504677
121Abnormal respiratory motile cilium physiology (HP:0012261)1.74234008
122Congenital primary aphakia (HP:0007707)1.72455132
123Nephroblastoma (Wilms tumor) (HP:0002667)1.72215512
124Recurrent pneumonia (HP:0006532)1.71851626
125Hyperphosphatemia (HP:0002905)1.71265408
126Thyroid-stimulating hormone excess (HP:0002925)1.70753632
127Facial cleft (HP:0002006)1.70241564
128Anencephaly (HP:0002323)1.69373530
129Aplasia of the musculature (HP:0100854)1.63681158
130Fetal akinesia sequence (HP:0001989)1.62189756
131Hyperkalemia (HP:0002153)1.62122556
132Popliteal pterygium (HP:0009756)1.61142718
133Asplenia (HP:0001746)1.59473349
134Aplasia/Hypoplasia of the spleen (HP:0010451)1.58525974
135Aplasia/Hypoplasia of the tongue (HP:0010295)1.57930853
136Hand muscle atrophy (HP:0009130)1.57455373
137Tubular atrophy (HP:0000092)1.56852694
138Nephropathy (HP:0000112)1.56824732
139Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.54686979
140Abnormality of the distal phalanges of the toes (HP:0010182)1.46902173
141Obstructive sleep apnea (HP:0002870)1.43570136
142Oculomotor apraxia (HP:0000657)1.42697323
143Abnormality of renin-angiotensin system (HP:0000847)1.40436226
144Abnormality of chloride homeostasis (HP:0011422)1.37936462
145Hyponatremia (HP:0002902)1.37316372
146Short thorax (HP:0010306)1.36272121
147Furrowed tongue (HP:0000221)1.35394400
148Hyperaldosteronism (HP:0000859)1.35030815
149Lip pit (HP:0100267)1.34849039
150Flat acetabular roof (HP:0003180)1.34171981
151Short nail (HP:0001799)1.30377471
152Glucose intolerance (HP:0000833)1.29282896
153Sclerocornea (HP:0000647)1.28366666
154Distal upper limb amyotrophy (HP:0007149)1.28023970
155Upper limb amyotrophy (HP:0009129)1.28023970
156Stridor (HP:0010307)1.27395154
157Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.25810128
158Abnormality of the frontal sinuses (HP:0002687)1.22009791
159Postaxial hand polydactyly (HP:0001162)1.21707825
160Short femoral neck (HP:0100864)1.20393716
161Gait imbalance (HP:0002141)1.20062635
162Self-mutilation (HP:0000742)1.18432865
163Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.17230594
164Dyschromatopsia (HP:0007641)1.16525440
165Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.16289206
166Spinal cord compression (HP:0002176)1.15845381
167Abnormality of the dental root (HP:0006486)1.15605829
168Taurodontia (HP:0000679)1.15605829
169Abnormality of permanent molar morphology (HP:0011071)1.15605829
170Hypokalemic alkalosis (HP:0001949)1.12822459
171Bifid scrotum (HP:0000048)1.12386755
172Stage 5 chronic kidney disease (HP:0003774)1.12010241
173Distal lower limb muscle weakness (HP:0009053)1.11984772
174Testicular atrophy (HP:0000029)1.09791799
175Abnormality of monocarboxylic acid metabolism (HP:0010996)1.09356205
176Ulnar bowing (HP:0003031)1.06369754
177Abnormality of molar morphology (HP:0011070)1.04415314
178Abnormality of molar (HP:0011077)1.04415314
179Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.03699209
180Abnormality of the dental pulp (HP:0006479)1.00920759
181Cone-rod dystrophy (HP:0000548)1.00226961

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.68323576
2CASK4.44921910
3MST44.02451264
4IRAK33.73132251
5TNIK3.43463555
6STK163.40204227
7SMG13.15455681
8TRIB32.91112868
9IRAK42.84112351
10EEF2K2.61252219
11ZAK2.57140055
12EIF2AK22.54472435
13TXK2.51009325
14BLK2.34842867
15MAP3K142.30833074
16MKNK22.28240072
17MUSK2.24561969
18MAPKAPK32.22700578
19SRPK11.96387771
20NME11.93195903
21IRAK11.92348449
22PRPF4B1.85020006
23YES11.80677840
24ADRBK21.78009020
25IRAK21.67833336
26MAP3K21.65134297
27EIF2AK31.64176384
28SIK31.58134899
29GRK11.55875106
30MAP2K71.53100111
31NLK1.52196257
32MST1R1.51174323
33MAP3K31.50218449
34NEK61.50213341
35ICK1.48364650
36CSK1.47718865
37TNK21.47481725
38TTK1.46405501
39MAPK131.35905510
40MKNK11.33711316
41BMPR21.33382283
42TLK11.25302294
43MAP3K121.23501158
44IKBKE1.20698733
45GRK71.20627571
46STK241.20571418
47CLK11.17424056
48LRRK21.17131133
49MARK21.14153591
50TBK11.14152218
51TEC1.13575325
52GRK61.12951584
53EPHB11.10392582
54CDK31.10157409
55EPHA31.08195437
56VRK11.00359045
57BMPR1B0.99711330
58INSRR0.99048854
59PBK0.97328048
60AKT30.95912953
61PLK40.95545399
62SGK20.94556566
63PRKCI0.91596970
64PTK2B0.89584626
65TESK10.88392589
66CAMKK10.87327995
67MAP3K70.85896960
68SIK10.85855256
69IKBKB0.85786951
70STK100.80158331
71STK38L0.78856878
72PDPK10.76614350
73ERN10.76591725
74RPS6KB20.76538519
75PKN20.76012141
76PKN10.73915516
77MAPK150.73473816
78LYN0.73430649
79PINK10.69903599
80BTK0.68750531
81RIPK10.68089478
82NME20.67384911
83BRD40.66836328
84PRKD20.66186672
85TAOK20.64790085
86CDK80.63116756
87PAK40.63046181
88KIT0.62180879
89ERBB30.61343299
90PIK3CG0.60097557
91PRKCE0.59983427
92WNK40.59550534
93TIE10.58949288
94PRKD30.58844551
95SGK2230.58636734
96SGK4940.58636734
97FES0.58320485
98RPS6KA20.57787609
99AURKA0.56281708
100MAP2K60.55623512
101TAOK10.53698104
102TRPM70.52840974
103ERBB20.52808169
104PTK60.51686143
105STK380.51503386
106MAP2K20.50657095
107NTRK30.50490292
108SYK0.49520229
109DYRK20.48514257
110CAMK10.47697747
111CDK60.46751389
112MAP2K30.45377343
113ZAP700.45332722
114CDC42BPA0.44663411
115DYRK1B0.44573278
116BCR0.44183587
117JAK30.41962313
118JAK10.39801259
119CHUK0.38851401
120CAMK2G0.38787395
121FGFR40.38561522
122LCK0.37772152
123CDK120.37592474
124ATR0.37314984
125ADRBK10.35919491
126MAPK70.35598841
127HCK0.35143742
128PRKCG0.34380740
129MET0.33984454
130CDK190.33881583
131PIM20.33835349
132DYRK1A0.33781727
133WNK30.31466856
134PRKCD0.31085271
135SIK20.30567137
136MAP2K40.30288062
137AKT20.30091394
138PRKCQ0.29809136
139RPS6KA50.29797113
140RIPK40.28890466
141MTOR0.28872080
142RPS6KL10.28481945
143RPS6KC10.28481945
144PRKACA0.28301885
145STK40.28046336
146PRKAA20.27229758
147NUAK10.27052446
148RPS6KA60.26668477
149CHEK20.26070611
150ILK0.25301339
151PRKG10.25191899
152RET0.24771097
153MARK10.24216847
154SGK10.23877199
155MYLK0.23325720
156HIPK20.22451654
157CAMK2B0.22185620
158PDK10.22105430
159CAMKK20.22054624
160MAPK120.21999050
161MAP3K110.21666561
162FGFR30.19969334
163LMTK20.19883568
164MAPK110.19290325
165PRKD10.19063607
166PAK10.18550618
167PTK20.16735103
168ARAF0.15485019
169MAP3K60.15088232
170PNCK0.14571567
171MELK0.13746678
172MAP3K80.11911979
173TYK20.11651985
174SRC0.11487520
175CDK40.11222806
176PLK10.11208063
177MAPKAPK50.10548209

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003605.29121277
2Chemical carcinogenesis_Homo sapiens_hsa052044.24793191
3Tyrosine metabolism_Homo sapiens_hsa003503.98643866
4Fanconi anemia pathway_Homo sapiens_hsa034602.71028709
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.61639367
6Glutathione metabolism_Homo sapiens_hsa004802.60833233
7Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.39690161
8Homologous recombination_Homo sapiens_hsa034402.22704876
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.17501169
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.17255292
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.00614188
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.00437980
13Primary immunodeficiency_Homo sapiens_hsa053401.99638818
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.88828164
15Graft-versus-host disease_Homo sapiens_hsa053321.86936411
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.83167894
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.82248459
18Allograft rejection_Homo sapiens_hsa053301.80793303
19Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.79606106
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.76586854
21Autoimmune thyroid disease_Homo sapiens_hsa053201.76083514
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.75591809
23Phototransduction_Homo sapiens_hsa047441.65970015
24Arachidonic acid metabolism_Homo sapiens_hsa005901.64715763
25Protein export_Homo sapiens_hsa030601.62802545
26Nicotine addiction_Homo sapiens_hsa050331.61054173
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.58628371
28Non-homologous end-joining_Homo sapiens_hsa034501.56877775
29Basal transcription factors_Homo sapiens_hsa030221.48189397
30Hematopoietic cell lineage_Homo sapiens_hsa046401.47159544
31Other glycan degradation_Homo sapiens_hsa005111.46927955
32Caffeine metabolism_Homo sapiens_hsa002321.45837047
33Notch signaling pathway_Homo sapiens_hsa043301.40148787
34Sphingolipid metabolism_Homo sapiens_hsa006001.34922957
35RNA polymerase_Homo sapiens_hsa030201.33349257
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.32644503
37Fructose and mannose metabolism_Homo sapiens_hsa000511.32630635
38Tight junction_Homo sapiens_hsa045301.29115053
39Measles_Homo sapiens_hsa051621.28889877
40Carbohydrate digestion and absorption_Homo sapiens_hsa049731.24754255
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.18618570
42Asthma_Homo sapiens_hsa053101.17600543
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.17486651
44Morphine addiction_Homo sapiens_hsa050321.15371817
45Rheumatoid arthritis_Homo sapiens_hsa053231.13901941
46Ether lipid metabolism_Homo sapiens_hsa005651.13601324
47Maturity onset diabetes of the young_Homo sapiens_hsa049501.12280874
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.12101708
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.09844424
50Hepatitis C_Homo sapiens_hsa051601.09792660
51Fatty acid degradation_Homo sapiens_hsa000711.08253304
52Taste transduction_Homo sapiens_hsa047421.07843276
53Glycosaminoglycan degradation_Homo sapiens_hsa005311.05786275
54Pyrimidine metabolism_Homo sapiens_hsa002401.05451100
55Base excision repair_Homo sapiens_hsa034101.04583529
56Purine metabolism_Homo sapiens_hsa002301.02870648
57Regulation of autophagy_Homo sapiens_hsa041400.98831379
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94523957
59DNA replication_Homo sapiens_hsa030300.93251300
60Mismatch repair_Homo sapiens_hsa034300.89935137
61Linoleic acid metabolism_Homo sapiens_hsa005910.89477076
62Choline metabolism in cancer_Homo sapiens_hsa052310.89358507
63Herpes simplex infection_Homo sapiens_hsa051680.88967328
64Basal cell carcinoma_Homo sapiens_hsa052170.88910124
65NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85749696
66Sulfur relay system_Homo sapiens_hsa041220.83926200
67Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.83394822
68Nucleotide excision repair_Homo sapiens_hsa034200.83371776
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.82383883
70Type I diabetes mellitus_Homo sapiens_hsa049400.82293954
71Ribosome_Homo sapiens_hsa030100.80335342
72Lysosome_Homo sapiens_hsa041420.80063119
73Serotonergic synapse_Homo sapiens_hsa047260.79730479
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.78050505
75Toll-like receptor signaling pathway_Homo sapiens_hsa046200.78027746
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.74990622
77Leishmaniasis_Homo sapiens_hsa051400.74808525
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74254242
79Histidine metabolism_Homo sapiens_hsa003400.72195444
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.72178711
81Oxidative phosphorylation_Homo sapiens_hsa001900.71947626
82Retinol metabolism_Homo sapiens_hsa008300.71313354
83Peroxisome_Homo sapiens_hsa041460.70155538
84Salivary secretion_Homo sapiens_hsa049700.69759312
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.67992780
86Phagosome_Homo sapiens_hsa041450.67360602
87Malaria_Homo sapiens_hsa051440.66357782
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63850898
89RNA degradation_Homo sapiens_hsa030180.62303042
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61625013
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59460840
92beta-Alanine metabolism_Homo sapiens_hsa004100.58073054
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56783868
94TNF signaling pathway_Homo sapiens_hsa046680.56440816
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55668337
96Steroid biosynthesis_Homo sapiens_hsa001000.54893823
97Ovarian steroidogenesis_Homo sapiens_hsa049130.54550665
98mTOR signaling pathway_Homo sapiens_hsa041500.54259917
99Insulin resistance_Homo sapiens_hsa049310.53948786
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53921157
101Insulin secretion_Homo sapiens_hsa049110.53204606
102Vitamin digestion and absorption_Homo sapiens_hsa049770.52399779
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51320501
104Hedgehog signaling pathway_Homo sapiens_hsa043400.51231001
105Chemokine signaling pathway_Homo sapiens_hsa040620.51117365
106Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49007476
107Circadian rhythm_Homo sapiens_hsa047100.48656428
108Collecting duct acid secretion_Homo sapiens_hsa049660.48188863
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47569928
110Pertussis_Homo sapiens_hsa051330.47343583
111ABC transporters_Homo sapiens_hsa020100.46767707
112Spliceosome_Homo sapiens_hsa030400.46503298
113Huntingtons disease_Homo sapiens_hsa050160.46030949
114Calcium signaling pathway_Homo sapiens_hsa040200.45979791
115African trypanosomiasis_Homo sapiens_hsa051430.45892872
116Glutamatergic synapse_Homo sapiens_hsa047240.44183504
117N-Glycan biosynthesis_Homo sapiens_hsa005100.43884630
118Starch and sucrose metabolism_Homo sapiens_hsa005000.43877290
119Wnt signaling pathway_Homo sapiens_hsa043100.43551775
120Influenza A_Homo sapiens_hsa051640.42121761
121Endocytosis_Homo sapiens_hsa041440.40068370
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.39696444
123Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.39596355
124p53 signaling pathway_Homo sapiens_hsa041150.38628457
125Adherens junction_Homo sapiens_hsa045200.38555851
126Osteoclast differentiation_Homo sapiens_hsa043800.37999908
127Olfactory transduction_Homo sapiens_hsa047400.37165730
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37137471
129Fatty acid elongation_Homo sapiens_hsa000620.36220357
130Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36151841
131Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35960623
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34231334
133Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33390425
134Cocaine addiction_Homo sapiens_hsa050300.32489787
135Hippo signaling pathway_Homo sapiens_hsa043900.32240342
136Prostate cancer_Homo sapiens_hsa052150.32032976
137Endometrial cancer_Homo sapiens_hsa052130.31619833
138Amoebiasis_Homo sapiens_hsa051460.29708880
139Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29632573
140PPAR signaling pathway_Homo sapiens_hsa033200.26573083
141Pancreatic cancer_Homo sapiens_hsa052120.26162389
142Melanogenesis_Homo sapiens_hsa049160.24747493
143Apoptosis_Homo sapiens_hsa042100.23429103
144Neurotrophin signaling pathway_Homo sapiens_hsa047220.22978854
145Metabolic pathways_Homo sapiens_hsa011000.20828619
146VEGF signaling pathway_Homo sapiens_hsa043700.18740269
147Acute myeloid leukemia_Homo sapiens_hsa052210.18694866
148Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.18587098
149Inositol phosphate metabolism_Homo sapiens_hsa005620.17145498
150cAMP signaling pathway_Homo sapiens_hsa040240.16914921
151Non-small cell lung cancer_Homo sapiens_hsa052230.16052266
152Fatty acid biosynthesis_Homo sapiens_hsa000610.14378713
153Pyruvate metabolism_Homo sapiens_hsa006200.13966374
154Pentose and glucuronate interconversions_Homo sapiens_hsa000400.12710051
155Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.11894978
156Chronic myeloid leukemia_Homo sapiens_hsa052200.11089404
157Arginine biosynthesis_Homo sapiens_hsa002200.09994257
158Arginine and proline metabolism_Homo sapiens_hsa003300.09738469
159Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.09702930
160Bile secretion_Homo sapiens_hsa049760.09509087
161Vibrio cholerae infection_Homo sapiens_hsa051100.08451083
162Adipocytokine signaling pathway_Homo sapiens_hsa049200.07302796
163Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.07221731
164Insulin signaling pathway_Homo sapiens_hsa049100.06868008

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