CCDC8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a cofactor required for p53-mediated apoptosis following DNA damage, and may also play a role in growth through interactions with the cytoskeletal adaptor protein obscurin-like 1. Mutations in this gene are a cause of 3M syndrome-3 (3M3). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)9.14833721
2bundle of His cell to Purkinje myocyte communication (GO:0086069)4.27181129
3desmosome organization (GO:0002934)4.15470272
4lateral sprouting from an epithelium (GO:0060601)3.79953378
5negative regulation of keratinocyte proliferation (GO:0010839)3.53935078
6cell proliferation involved in metanephros development (GO:0072203)3.53820612
7cell-substrate junction assembly (GO:0007044)3.39764234
8establishment of tissue polarity (GO:0007164)3.33018700
9establishment of planar polarity (GO:0001736)3.33018700
10atrial septum morphogenesis (GO:0060413)3.25596242
11paraxial mesoderm development (GO:0048339)3.25155408
12endodermal cell differentiation (GO:0035987)3.20379887
13regulation of transforming growth factor beta2 production (GO:0032909)3.20017069
14convergent extension (GO:0060026)3.19155108
15positive regulation of hormone biosynthetic process (GO:0046886)3.12240446
16mesenchymal cell differentiation involved in renal system development (GO:2001012)3.11229786
17mesenchymal cell differentiation involved in kidney development (GO:0072161)3.11229786
18bone trabecula formation (GO:0060346)3.05129145
19mesenchyme morphogenesis (GO:0072132)3.04525360
20atrioventricular valve morphogenesis (GO:0003181)3.03710839
21regulation of hair follicle development (GO:0051797)3.03423132
22exocrine pancreas development (GO:0031017)3.02958221
23polarized epithelial cell differentiation (GO:0030859)3.02040394
24planar cell polarity pathway involved in neural tube closure (GO:0090179)2.98882724
25somite development (GO:0061053)2.95939848
26protein heterotrimerization (GO:0070208)2.95213414
27DNA integration (GO:0015074)2.94844465
28muscle cell fate commitment (GO:0042693)2.94034152
29daunorubicin metabolic process (GO:0044597)2.93966460
30polyketide metabolic process (GO:0030638)2.93966460
31doxorubicin metabolic process (GO:0044598)2.93966460
32regulation of keratinocyte proliferation (GO:0010837)2.92032115
33regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.91554972
34cardiac right ventricle morphogenesis (GO:0003215)2.88963188
35lung-associated mesenchyme development (GO:0060484)2.88297509
36regulation of secondary heart field cardioblast proliferation (GO:0003266)2.87734983
37regulation of cardioblast proliferation (GO:0003264)2.87734983
38renal system development (GO:0072001)2.83015258
39tongue development (GO:0043586)2.75960048
40energy homeostasis (GO:0097009)2.75878390
41regulation of non-canonical Wnt signaling pathway (GO:2000050)2.75860691
42regulation of activation of Janus kinase activity (GO:0010533)2.74866402
43negative regulation of epidermis development (GO:0045683)2.74585774
44establishment or maintenance of monopolar cell polarity (GO:0061339)2.73478162
45establishment of monopolar cell polarity (GO:0061162)2.73478162
46ganglion development (GO:0061548)2.73390088
47non-canonical Wnt signaling pathway (GO:0035567)2.72876907
48mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.72832499
49cell proliferation involved in kidney development (GO:0072111)2.72722947
50cell migration involved in heart development (GO:0060973)2.71444238
51establishment of apical/basal cell polarity (GO:0035089)2.70937057
52metanephric mesenchyme development (GO:0072075)2.70230582
53positive regulation of natural killer cell differentiation (GO:0032825)2.69741938
54response to peptidoglycan (GO:0032494)2.68588482
55regulation of male gonad development (GO:2000018)2.67815210
56gap junction assembly (GO:0016264)2.64774592
57notochord development (GO:0030903)2.61552888
58negative regulation of cartilage development (GO:0061037)2.60812497
59cardiac myofibril assembly (GO:0055003)2.60284027
60pattern specification involved in kidney development (GO:0061004)2.59588045
61neuron projection extension involved in neuron projection guidance (GO:1902284)2.58852392
62axon extension involved in axon guidance (GO:0048846)2.58852392
63myofibril assembly (GO:0030239)2.58441833
64embryonic camera-type eye development (GO:0031076)2.58255149
65collagen catabolic process (GO:0030574)2.56973766
66natural killer cell activation involved in immune response (GO:0002323)2.55755036
67kidney mesenchyme development (GO:0072074)2.55365377
68negative regulation of axon extension involved in axon guidance (GO:0048843)2.54339275
69neural crest cell development (GO:0014032)2.53533742
70collagen metabolic process (GO:0032963)2.52735277
71cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.52489331
72outflow tract septum morphogenesis (GO:0003148)2.51724413
73superoxide anion generation (GO:0042554)2.51235936
74endocardial cushion morphogenesis (GO:0003203)2.49913719
75detection of molecule of bacterial origin (GO:0032490)2.49279726
76proximal/distal pattern formation (GO:0009954)2.49090846
77cell differentiation involved in metanephros development (GO:0072202)2.49039633
78embryonic skeletal joint morphogenesis (GO:0060272)2.48961854
79negative regulation of catenin import into nucleus (GO:0035414)2.47517028
80head development (GO:0060322)2.46989185
81camera-type eye morphogenesis (GO:0048593)2.46744430
82dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.45981357
83regulation of interleukin-8 secretion (GO:2000482)2.45560366
84negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.44899330
85negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.44575710
86production of molecular mediator involved in inflammatory response (GO:0002532)2.43990488
87skin development (GO:0043588)2.42834680
88sequestering of extracellular ligand from receptor (GO:0035581)2.42714135
89regulation of heart morphogenesis (GO:2000826)2.41707075
90androgen biosynthetic process (GO:0006702)2.40914266
91glomerular basement membrane development (GO:0032836)2.38909487
92negative chemotaxis (GO:0050919)2.38574324
93establishment of epithelial cell polarity (GO:0090162)2.38137431
94negative regulation of viral genome replication (GO:0045071)2.37614384
95cardiac cell development (GO:0055006)2.37355288
96negative regulation of axon guidance (GO:1902668)2.37331846
97dorsal/ventral axis specification (GO:0009950)2.37159364
98regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.36583648
99heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.35236531
100segment specification (GO:0007379)2.35134968
101extracellular matrix disassembly (GO:0022617)2.34315055
102positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.34203040
103gonadal mesoderm development (GO:0007506)2.33890124
104embryonic camera-type eye morphogenesis (GO:0048596)2.33687108
105collagen fibril organization (GO:0030199)2.32751437
106anatomical structure regression (GO:0060033)2.32698067
107negative regulation of striated muscle cell apoptotic process (GO:0010664)2.32619521
108G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.32362630
109multicellular organismal macromolecule metabolic process (GO:0044259)2.31569659
110keratinocyte proliferation (GO:0043616)2.30794084
111mesenchymal cell differentiation (GO:0048762)2.30540181
112multicellular organismal catabolic process (GO:0044243)2.30116632
113facial nerve structural organization (GO:0021612)2.27385151
114response to interferon-alpha (GO:0035455)2.27275987
115cardiac muscle tissue development (GO:0048738)2.27203047
116cardiac muscle cell development (GO:0055013)2.25767999
117urogenital system development (GO:0001655)2.25589350
118antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.25101786
119regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.25085866
120ventricular trabecula myocardium morphogenesis (GO:0003222)2.25081847
121muscle atrophy (GO:0014889)2.24597983
122endosome to melanosome transport (GO:0035646)2.23860744
123endosome to pigment granule transport (GO:0043485)2.23860744
124ectoderm development (GO:0007398)2.23101404
125face development (GO:0060324)2.22596273
126regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.22558918
127cochlea morphogenesis (GO:0090103)2.21070994
128extracellular negative regulation of signal transduction (GO:1900116)2.20934880
129extracellular regulation of signal transduction (GO:1900115)2.20934880
130sarcomere organization (GO:0045214)2.20127940
131multicellular organismal metabolic process (GO:0044236)2.19929979
132outer ear morphogenesis (GO:0042473)2.19870044
133peripheral nervous system axon ensheathment (GO:0032292)2.19415649
134myelination in peripheral nervous system (GO:0022011)2.19415649
135mesenchymal cell development (GO:0014031)2.19061329
136mesenchyme development (GO:0060485)2.18584218
137regulation of nuclear cell cycle DNA replication (GO:0033262)2.18042038
138nonmotile primary cilium assembly (GO:0035058)2.17040696
139striated muscle atrophy (GO:0014891)2.16622690
140establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.16519441
141ventricular cardiac muscle cell development (GO:0055015)2.16278728
142regulation of posttranscriptional gene silencing (GO:0060147)2.16175276
143regulation of gene silencing by miRNA (GO:0060964)2.16175276
144regulation of gene silencing by RNA (GO:0060966)2.16175276
145positive regulation of smoothened signaling pathway (GO:0045880)2.15480349
146positive regulation of male gonad development (GO:2000020)2.14794745
147neuronal stem cell maintenance (GO:0097150)2.14755535
148left/right pattern formation (GO:0060972)2.14695659
149mesenchymal cell proliferation (GO:0010463)2.14238085
150limb bud formation (GO:0060174)2.14217465
151regulation of axon extension involved in axon guidance (GO:0048841)2.13294931
152negative regulation of myotube differentiation (GO:0010832)2.12686419
153regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.12269632
154lymphangiogenesis (GO:0001946)2.11825339
155definitive hemopoiesis (GO:0060216)2.11108861
156cellular response to exogenous dsRNA (GO:0071360)2.10722810
157dendritic cell chemotaxis (GO:0002407)2.10392872
158cellular response to interferon-beta (GO:0035458)2.09805630
159embryonic eye morphogenesis (GO:0048048)2.07758231
160positive regulation of cAMP-mediated signaling (GO:0043950)2.06120195
161negative regulation of chondrocyte differentiation (GO:0032331)2.05587898
162embryonic appendage morphogenesis (GO:0035113)2.05349794
163embryonic limb morphogenesis (GO:0030326)2.05349794
164wound healing, spreading of epidermal cells (GO:0035313)2.04965512
165regulation of stem cell maintenance (GO:2000036)2.04946298
166positive regulation of T cell chemotaxis (GO:0010820)2.04858554
167regulation of T cell chemotaxis (GO:0010819)2.04858554
168epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.03309677
169negative regulation of glycogen biosynthetic process (GO:0045719)2.02937432
170regulation of cardioblast differentiation (GO:0051890)2.02933314
171positive regulation of type 2 immune response (GO:0002830)2.02542637
172Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.01615870
173regulation of establishment of planar polarity (GO:0090175)2.01384493
174response to UV-B (GO:0010224)2.00468552
175replicative senescence (GO:0090399)2.00415601
176mesenchymal to epithelial transition (GO:0060231)2.00236776

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.31105547
2TP63_19390658_ChIP-ChIP_HaCaT_Human4.71992156
3E2F7_22180533_ChIP-Seq_HELA_Human4.10027771
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.64245955
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.64039376
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.20103870
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.77722542
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.70892424
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.63100317
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.59597659
11EZH2_22144423_ChIP-Seq_EOC_Human2.55134043
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.52112586
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.44125790
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.28428184
15POU5F1_16153702_ChIP-ChIP_HESCs_Human2.09904546
16EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.99664001
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.97584851
18PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.94091246
19EZH2_18974828_ChIP-Seq_MESCs_Mouse1.92324900
20RNF2_18974828_ChIP-Seq_MESCs_Mouse1.92324900
21CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.90768953
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88495856
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.83079606
24RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82552240
25HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.82376531
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.82346459
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.80553763
28DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.79342757
29SCL_19346495_ChIP-Seq_HPC-7_Human1.77364182
30FOXM1_23109430_ChIP-Seq_U2OS_Human1.74695069
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73887535
32CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.72453810
33PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.68904876
34WT1_19549856_ChIP-ChIP_CCG9911_Human1.61246223
35SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.58000103
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.57303126
37JARID2_20064375_ChIP-Seq_MESCs_Mouse1.54667024
38SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.52338593
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.49810085
40RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.48531731
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.48330336
42TP53_20018659_ChIP-ChIP_R1E_Mouse1.48291586
43SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.45673394
44SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45350579
45JARID2_20075857_ChIP-Seq_MESCs_Mouse1.43991053
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.43519704
47TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42683255
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42241280
49EZH2_27294783_Chip-Seq_ESCs_Mouse1.39681656
50SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.39350667
51IRF8_27001747_Chip-Seq_BMDM_Mouse1.38296620
52ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.37758335
53IGF1R_20145208_ChIP-Seq_DFB_Human1.37468707
54E2F4_17652178_ChIP-ChIP_JURKAT_Human1.36720406
55STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.35972492
56SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.34080673
57GBX2_23144817_ChIP-Seq_PC3_Human1.32696497
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30530638
59SOX9_24532713_ChIP-Seq_HFSC_Mouse1.30196492
60ISL1_27105846_Chip-Seq_CPCs_Mouse1.29018283
61RING1B_27294783_Chip-Seq_ESCs_Mouse1.27699012
62EZH2_27304074_Chip-Seq_ESCs_Mouse1.26630514
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.26352545
64SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.26262685
65KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.25363270
66RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.25345163
67NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.24226170
68MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.23963325
69EP300_21415370_ChIP-Seq_HL-1_Mouse1.22983435
70LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21560044
71ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.20235235
72SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18424301
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.17787362
74GATA4_21415370_ChIP-Seq_HL-1_Mouse1.17074223
75WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17050688
76RING1B_27294783_Chip-Seq_NPCs_Mouse1.16689970
77NFIB_24661679_ChIP-Seq_LUNG_Mouse1.15822771
78TP53_18474530_ChIP-ChIP_U2OS_Human1.15578423
79NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.14347760
80TRIM28_21343339_ChIP-Seq_HEK293_Human1.14304258
81NFI_21473784_ChIP-Seq_ESCs_Mouse1.13276593
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12291218
83TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11982098
84BRD4_25478319_ChIP-Seq_HGPS_Human1.11596778
85IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11587251
86RNF2_27304074_Chip-Seq_NSC_Mouse1.11516102
87STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11324019
88KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.10830018
89KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.10830018
90KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.10830018
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.10224997
92KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09764011
93GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08774056
94MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07997621
95POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07875922
96* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07527862
97GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.07312868
98STAT3_18555785_Chip-Seq_ESCs_Mouse1.06746070
99GATA2_21666600_ChIP-Seq_HMVEC_Human1.05038514
100SPI1_23547873_ChIP-Seq_NB4_Human1.02121322
101FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.02068365
102NANOG_16153702_ChIP-ChIP_HESCs_Human1.01997822
103MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01470818
104KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01335090
105NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01320237
106PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00879161
107EZH2_27294783_Chip-Seq_NPCs_Mouse0.99987975
108ZNF274_21170338_ChIP-Seq_K562_Hela0.99547255
109LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99392096
110P53_22387025_ChIP-Seq_ESCs_Mouse0.99338568
111ERG_21242973_ChIP-ChIP_JURKAT_Human0.98780386
112STAT4_19710469_ChIP-ChIP_TH1__Mouse0.98610853
113NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98088030
114TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.97186248
115RARG_19884340_ChIP-ChIP_MEFs_Mouse0.97115362
116FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.96884924
117ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96346826
118FUS_26573619_Chip-Seq_HEK293_Human0.96239909
119RNF2_27304074_Chip-Seq_ESCs_Mouse0.95051523
120SMAD3_21741376_ChIP-Seq_HESCs_Human0.94963047
121SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.94609169
122E2F1_21310950_ChIP-Seq_MCF-7_Human0.94590617
123EWS_26573619_Chip-Seq_HEK293_Human0.94449652
124EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94355071
125STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93968386
126CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93466608
127* CTCF_27219007_Chip-Seq_Bcells_Human0.93432011
128ZFX_18555785_Chip-Seq_ESCs_Mouse0.93371820
129TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92602139
130SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92544912
131ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92111130
132SOX2_16153702_ChIP-ChIP_HESCs_Human0.91874639
133NMYC_18555785_Chip-Seq_ESCs_Mouse0.91712661
134P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91516046
135SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.91272711
136SUZ12_18555785_Chip-Seq_ESCs_Mouse0.90990698
137PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90960956
138SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.90923852
139ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.90429285
140MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.90276371
141E2F1_18555785_Chip-Seq_ESCs_Mouse0.90016163
142SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.90011881
143SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.90011881
144CJUN_26792858_Chip-Seq_BT549_Human0.89331866
145TBL1_22424771_ChIP-Seq_293T_Human0.88860732
146DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88391869
147* TP53_23651856_ChIP-Seq_MEFs_Mouse0.86150445
148CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.85358985
149PIAS1_25552417_ChIP-Seq_VCAP_Human0.84669095
150* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84663391
151SMAD4_21799915_ChIP-Seq_A2780_Human0.84267242
152TBX3_20139965_ChIP-Seq_ESCs_Mouse0.83476451
153TBX3_20139965_ChIP-Seq_MESCs_Mouse0.82868029
154POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.82300280
155TP53_16413492_ChIP-PET_HCT116_Human0.81568983
156SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.81505129
157UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.81476687
158TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.81137259
159SMAD3_21741376_ChIP-Seq_EPCs_Human0.81014869
160TP53_22127205_ChIP-Seq_IMR90_Human0.78926089
161TAF15_26573619_Chip-Seq_HEK293_Human0.77945311
162PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.76746768
163HIF1A_21447827_ChIP-Seq_MCF-7_Human0.76714155
164AR_21572438_ChIP-Seq_LNCaP_Human0.74618482
165POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.73237769
166TET1_21490601_ChIP-Seq_MESCs_Mouse0.72726569
167ZFP281_18757296_ChIP-ChIP_E14_Mouse0.72334372
168LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72042351

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology4.71636102
2MP0003122_maternal_imprinting3.35608645
3MP0005503_abnormal_tendon_morphology3.08669201
4MP0003941_abnormal_skin_development3.00341999
5MP0008438_abnormal_cutaneous_collagen2.80778475
6MP0000566_synostosis2.71824808
7MP0010030_abnormal_orbit_morphology2.62442929
8MP0003123_paternal_imprinting2.41399788
9MP0003385_abnormal_body_wall2.28952332
10MP0002938_white_spotting2.14392232
11MP0003121_genomic_imprinting2.04717727
12MP0000537_abnormal_urethra_morphology2.04135373
13MP0000049_abnormal_middle_ear1.92628711
14MP0008789_abnormal_olfactory_epithelium1.83637794
15MP0002837_dystrophic_cardiac_calcinosis1.79896375
16MP0006292_abnormal_olfactory_placode1.79305203
17MP0003279_aneurysm1.79239390
18MP0000467_abnormal_esophagus_morphology1.77567669
19MP0003705_abnormal_hypodermis_morpholog1.76062674
20MP0006054_spinal_hemorrhage1.74887375
21MP0004272_abnormal_basement_membrane1.71186517
22MP0001299_abnormal_eye_distance/1.70208766
23MP0003787_abnormal_imprinting1.66553495
24MP0005508_abnormal_skeleton_morphology1.62027756
25MP0008007_abnormal_cellular_replicative1.60928908
26MP0003567_abnormal_fetal_cardiomyocyte1.60788585
27MP0000678_abnormal_parathyroid_gland1.60486008
28MP0005367_renal/urinary_system_phenotyp1.55666195
29MP0000516_abnormal_urinary_system1.55666195
30MP0009384_cardiac_valve_regurgitation1.54992034
31MP0001849_ear_inflammation1.53206411
32MP0000751_myopathy1.52578878
33MP0002249_abnormal_larynx_morphology1.51999765
34MP0003942_abnormal_urinary_system1.50885175
35MP0009250_abnormal_appendicular_skeleto1.49790620
36MP0002060_abnormal_skin_morphology1.47637930
37MP0002148_abnormal_hypersensitivity_rea1.46712505
38MP0000767_abnormal_smooth_muscle1.44012735
39MP0000569_abnormal_digit_pigmentation1.37842799
40MP0005623_abnormal_meninges_morphology1.36031548
41MP0001835_abnormal_antigen_presentation1.32199166
42MP0002932_abnormal_joint_morphology1.28922491
43MP0005275_abnormal_skin_tensile1.27879960
44MP0009278_abnormal_bone_marrow1.27846416
45MP0005394_taste/olfaction_phenotype1.27241515
46MP0005499_abnormal_olfactory_system1.27241515
47MP0003935_abnormal_craniofacial_develop1.26927120
48MP0003828_pulmonary_edema1.26923573
49MP0009053_abnormal_anal_canal1.25905149
50MP0004808_abnormal_hematopoietic_stem1.24326016
51MP0000428_abnormal_craniofacial_morphol1.20900742
52MP0004133_heterotaxia1.20348751
53MP0000383_abnormal_hair_follicle1.20303881
54MP0002116_abnormal_craniofacial_bone1.16390631
55MP0003283_abnormal_digestive_organ1.15388627
56MP0002098_abnormal_vibrissa_morphology1.15363340
57MP0002109_abnormal_limb_morphology1.15223441
58MP0000733_abnormal_muscle_development1.15151966
59MP0005257_abnormal_intraocular_pressure1.14321301
60MP0009785_altered_susceptibility_to1.14035183
61MP0010368_abnormal_lymphatic_system1.12302126
62MP0004858_abnormal_nervous_system1.11760730
63MP0003111_abnormal_nucleus_morphology1.09102640
64MP0008058_abnormal_DNA_repair1.05858558
65MP0003937_abnormal_limbs/digits/tail_de1.05377324
66MP0005390_skeleton_phenotype1.05361977
67MP0008775_abnormal_heart_ventricle1.05106632
68MP0000778_abnormal_nervous_system1.02882171
69MP0003119_abnormal_digestive_system1.00514837
70MP0003755_abnormal_palate_morphology0.99151754
71MP0002177_abnormal_outer_ear0.99092469
72MP0001270_distended_abdomen0.99018647
73MP0000163_abnormal_cartilage_morphology0.98919662
74MP0000685_abnormal_immune_system0.98419334
75MP0001346_abnormal_lacrimal_gland0.98271367
76MP0002396_abnormal_hematopoietic_system0.98222392
77MP0002234_abnormal_pharynx_morphology0.98208819
78MP0002282_abnormal_trachea_morphology0.97323360
79MP0000534_abnormal_ureter_morphology0.95801593
80MP0002115_abnormal_skeleton_extremities0.95408866
81MP0002233_abnormal_nose_morphology0.95084911
82MP0002113_abnormal_skeleton_development0.94959186
83MP0003566_abnormal_cell_adhesion0.94386828
84MP0001293_anophthalmia0.94373476
85MP0003115_abnormal_respiratory_system0.94311798
86MP0000681_abnormal_thyroid_gland0.94227042
87MP0002295_abnormal_pulmonary_circulatio0.93710771
88MP0000462_abnormal_digestive_system0.93577962
89MP0001879_abnormal_lymphatic_vessel0.93028389
90MP0002277_abnormal_respiratory_mucosa0.92634873
91MP0002163_abnormal_gland_morphology0.92314329
92MP0002127_abnormal_cardiovascular_syste0.90517180
93MP0003136_yellow_coat_color0.89137506
94MP0001661_extended_life_span0.89110684
95MP0000613_abnormal_salivary_gland0.88868315
96MP0005248_abnormal_Harderian_gland0.88307110
97MP0000432_abnormal_head_morphology0.87135573
98MP0002653_abnormal_ependyma_morphology0.87035794
99MP0005330_cardiomyopathy0.85818921
100MP0004885_abnormal_endolymph0.85760670
101MP0008932_abnormal_embryonic_tissue0.84957166
102MP0002092_abnormal_eye_morphology0.84480989
103MP0003646_muscle_fatigue0.84175965
104MP0000750_abnormal_muscle_regeneration0.83913069
105MP0005076_abnormal_cell_differentiation0.83900906
106MP0009379_abnormal_foot_pigmentation0.83644370
107MP0002084_abnormal_developmental_patter0.83149045
108MP0001958_emphysema0.82346972
109MP0002102_abnormal_ear_morphology0.81462191
110MP0001175_abnormal_lung_morphology0.81077863
111MP0001348_abnormal_lacrimal_gland0.80392632
112MP0001188_hyperpigmentation0.80095005
113MP0005377_hearing/vestibular/ear_phenot0.80041495
114MP0003878_abnormal_ear_physiology0.80041495
115MP0010386_abnormal_urinary_bladder0.79294826
116MP0002111_abnormal_tail_morphology0.79274888
117MP0005671_abnormal_response_to0.79167070
118MP0000377_abnormal_hair_follicle0.79033833
119MP0010678_abnormal_skin_adnexa0.78731912
120MP0004084_abnormal_cardiac_muscle0.78567718
121MP0001286_abnormal_eye_development0.78477398
122MP0002697_abnormal_eye_size0.78235985
123MP0000858_altered_metastatic_potential0.78170621
124MP0004197_abnormal_fetal_growth/weight/0.77573336
125MP0002114_abnormal_axial_skeleton0.75472195
126MP0004134_abnormal_chest_morphology0.74893501
127MP0003861_abnormal_nervous_system0.74698271
128MP0005409_darkened_coat_color0.74557322
129MP0002085_abnormal_embryonic_tissue0.74485010
130MP0003315_abnormal_perineum_morphology0.74165505
131MP0000013_abnormal_adipose_tissue0.73729271
132MP0002254_reproductive_system_inflammat0.73108468
133MP0000490_abnormal_crypts_of0.72900855
134MP0002925_abnormal_cardiovascular_devel0.72656582
135MP0000026_abnormal_inner_ear0.71547258
136MP0002896_abnormal_bone_mineralization0.71427778
137MP0001119_abnormal_female_reproductive0.71140710
138MP0003938_abnormal_ear_development0.70215895
139MP0002933_joint_inflammation0.68944333
140MP0010094_abnormal_chromosome_stability0.68837380
141MP0000538_abnormal_urinary_bladder0.68736442
142MP0003077_abnormal_cell_cycle0.67766451
143MP0010771_integument_phenotype0.67373363
144MP0000762_abnormal_tongue_morphology0.65766679
145MP0002108_abnormal_muscle_morphology0.65621500

Predicted human phenotypes

RankGene SetZ-score
1Fragile nails (HP:0001808)5.56665939
2Milia (HP:0001056)4.72744074
3Onycholysis (HP:0001806)4.24141754
4Plantar hyperkeratosis (HP:0007556)3.45562425
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.44685166
6Pterygium (HP:0001059)3.41007103
7Abnormality of nail color (HP:0100643)3.37706138
8Renal duplication (HP:0000075)3.14542100
9Short middle phalanx of the 5th finger (HP:0004220)3.03077566
10Chromsome breakage (HP:0040012)3.01494068
11Right ventricular cardiomyopathy (HP:0011663)3.00940114
12Alopecia of scalp (HP:0002293)2.99785494
13Type 1 muscle fiber predominance (HP:0003803)2.87960786
14Mesomelia (HP:0003027)2.82854052
15Protrusio acetabuli (HP:0003179)2.76085734
16Asymmetry of the thorax (HP:0001555)2.75388668
17Abnormality of the left ventricular outflow tract (HP:0011103)2.69399270
18Subaortic stenosis (HP:0001682)2.69399270
19Premature rupture of membranes (HP:0001788)2.68669672
20Follicular hyperkeratosis (HP:0007502)2.65259796
21Natal tooth (HP:0000695)2.61616824
22Morphological abnormality of the middle ear (HP:0008609)2.54427677
23Spinal cord lesions (HP:0100561)2.49742792
24Syringomyelia (HP:0003396)2.49742792
25Bladder diverticulum (HP:0000015)2.40884238
26Abnormality of the renal collecting system (HP:0004742)2.40171683
27Short 4th metacarpal (HP:0010044)2.35447623
28Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.35447623
29Abnormality of dentin (HP:0010299)2.32812448
30Pulmonary artery stenosis (HP:0004415)2.32047717
31Duplicated collecting system (HP:0000081)2.28450419
32Nephroblastoma (Wilms tumor) (HP:0002667)2.26079522
33Coronal craniosynostosis (HP:0004440)2.25510118
34Ankle contracture (HP:0006466)2.23529411
35Soft skin (HP:0000977)2.23492019
36Broad metatarsal (HP:0001783)2.18843938
37Renovascular hypertension (HP:0100817)2.16271099
38Patent foramen ovale (HP:0001655)2.16091984
39Ectopic kidney (HP:0000086)2.14346079
40Embryonal renal neoplasm (HP:0011794)2.14122725
41Abnormality of the parietal bone (HP:0002696)2.08638879
42Flat cornea (HP:0007720)2.08132449
43Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.08108210
44Esophageal atresia (HP:0002032)2.07987176
45Occipital encephalocele (HP:0002085)2.06534245
46Limited hip movement (HP:0008800)2.03685035
47Preaxial foot polydactyly (HP:0001841)2.03440854
48Thick nail (HP:0001805)2.03001676
49Shallow orbits (HP:0000586)2.02698667
50Abnormality of the 4th metacarpal (HP:0010012)2.02681094
51Midline defect of the nose (HP:0004122)2.01566009
52Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.01292687
53Abnormality of the labia majora (HP:0012881)2.00341636
54Short 5th finger (HP:0009237)2.00305795
55Broad palm (HP:0001169)1.98965245
56Mildly elevated creatine phosphokinase (HP:0008180)1.97222068
57Rib fusion (HP:0000902)1.96794042
58Hypodontia (HP:0000668)1.94367238
59Hypoplastic labia majora (HP:0000059)1.94316612
60Aortic dissection (HP:0002647)1.94234275
61Cutaneous finger syndactyly (HP:0010554)1.93779730
62Calcaneovalgus deformity (HP:0001848)1.93499851
63Fragile skin (HP:0001030)1.92825267
64Nail dystrophy (HP:0008404)1.92362928
65Ridged nail (HP:0001807)1.91795231
66Cutaneous syndactyly (HP:0012725)1.90970024
67Round ear (HP:0100830)1.90712702
68Aplastic anemia (HP:0001915)1.87937602
69Meckel diverticulum (HP:0002245)1.87242031
70Atrophic scars (HP:0001075)1.87067603
71Hyperacusis (HP:0010780)1.86620213
72Abnormality of the aortic arch (HP:0012303)1.86408137
73Hypoplasia of dental enamel (HP:0006297)1.84941324
74Breast hypoplasia (HP:0003187)1.83954823
75Abnormal sex determination (HP:0012244)1.83352394
76Sex reversal (HP:0012245)1.83352394
77Advanced eruption of teeth (HP:0006288)1.83013555
78Abnormality of the ileum (HP:0001549)1.82940730
79Genu recurvatum (HP:0002816)1.82514329
80Laryngomalacia (HP:0001601)1.82022650
81Periauricular skin pits (HP:0100277)1.81045699
82Preauricular pit (HP:0004467)1.81045699
83Neonatal short-limb short stature (HP:0008921)1.80437087
84* Sprengel anomaly (HP:0000912)1.80407104
85Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.79113598
86Renal dysplasia (HP:0000110)1.78350863
87Deformed tarsal bones (HP:0008119)1.78111210
88Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.77133385
89Thin ribs (HP:0000883)1.76780368
90Elfin facies (HP:0004428)1.76649880
91Hip contracture (HP:0003273)1.76164480
92Abnormality of the phalanges of the 5th finger (HP:0004213)1.75342765
93True hermaphroditism (HP:0010459)1.75130788
94Pili torti (HP:0003777)1.74551128
95Partial duplication of thumb phalanx (HP:0009944)1.73425578
96Abnormality of the radial head (HP:0003995)1.71886763
97Pancreatic fibrosis (HP:0100732)1.69810783
98Aplasia/Hypoplasia of the uvula (HP:0010293)1.69435431
99Mediastinal lymphadenopathy (HP:0100721)1.69057862
100Dislocated radial head (HP:0003083)1.68647030
101Unilateral renal agenesis (HP:0000122)1.68544234
102Partial duplication of the phalanx of hand (HP:0009999)1.67940554
103Abnormality of the neuromuscular junction (HP:0003398)1.67323988
104Fatigable weakness (HP:0003473)1.67323988
105Spinal rigidity (HP:0003306)1.66817846
106Absent phalangeal crease (HP:0006109)1.66666122
107Palmoplantar hyperkeratosis (HP:0000972)1.66241057
108Popliteal pterygium (HP:0009756)1.64964514
109Intestinal atresia (HP:0011100)1.64787221
110Abnormality of the right ventricle (HP:0001707)1.64585469
111Woolly hair (HP:0002224)1.64541893
112Abnormality of the calcaneus (HP:0008364)1.64309871
113Labial hypoplasia (HP:0000066)1.62552792
114Breech presentation (HP:0001623)1.61828259
115Hypoplastic female external genitalia (HP:0012815)1.61416185
116Palmar hyperkeratosis (HP:0010765)1.60224060
117Wide anterior fontanel (HP:0000260)1.59458025
118Optic nerve coloboma (HP:0000588)1.59055096
119Infantile muscular hypotonia (HP:0008947)1.58420230
120Abnormality of the intervertebral disk (HP:0005108)1.57686956
121Absent eyebrow (HP:0002223)1.57521414
122Abnormality of the carotid arteries (HP:0005344)1.57028395
123Aplasia of the musculature (HP:0100854)1.56624229
124Ventricular tachycardia (HP:0004756)1.56338684
125Overriding aorta (HP:0002623)1.54828896
126Abnormality of the endocardium (HP:0004306)1.53438508
127Gastrointestinal atresia (HP:0002589)1.53034686
128Long eyelashes (HP:0000527)1.51656286
129High anterior hairline (HP:0009890)1.51571191
130Bell-shaped thorax (HP:0001591)1.51487405
131Increased number of teeth (HP:0011069)1.51479121
132Absent frontal sinuses (HP:0002688)1.51426987
133Deep philtrum (HP:0002002)1.51004711
134Abnormality of the middle phalanges of the toes (HP:0010183)1.50704765
135Cervical subluxation (HP:0003308)1.50042804
136Vascular tortuosity (HP:0004948)1.49884683
137Bifid tongue (HP:0010297)1.49859602
138Vertebral compression fractures (HP:0002953)1.49002900
139Absent eyelashes (HP:0000561)1.48945683
140Trismus (HP:0000211)1.48844437
141* Slender long bone (HP:0003100)1.48486224
142Aplasia cutis congenita (HP:0001057)1.47992276
143Abnormality of placental membranes (HP:0011409)1.47966206
144Amniotic constriction ring (HP:0009775)1.47966206
145Bronchomalacia (HP:0002780)1.47288109
146Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.47130668
147Slender build (HP:0001533)1.46925816
148Hypoplastic heart (HP:0001961)1.46792178
149Vitreoretinal degeneration (HP:0000655)1.45975101
150Basal ganglia calcification (HP:0002135)1.45659768
151Symphalangism affecting the phalanges of the hand (HP:0009773)1.45458256
152Type 2 muscle fiber atrophy (HP:0003554)1.45424408
153Gingivitis (HP:0000230)1.45069804
154Exostoses (HP:0100777)1.44855701
155Hypoplastic ischia (HP:0003175)1.44834170
156Skin pits (HP:0100276)1.44265024
157Distal arthrogryposis (HP:0005684)1.43949522
158Mitral valve prolapse (HP:0001634)1.43740432
159Bowel diverticulosis (HP:0005222)1.43364011
160Broad long bones (HP:0005622)1.43221938
161Recurrent abscess formation (HP:0002722)1.43017603
162Selective tooth agenesis (HP:0001592)1.42771853
163Carpal synostosis (HP:0009702)1.42658588
164Hepatoblastoma (HP:0002884)1.42518687
165Joint contractures involving the joints of the feet (HP:0100492)1.42449483
166Flexion contracture of toe (HP:0005830)1.42449483
167Synostosis of carpal bones (HP:0005048)1.42333488
168Craniofacial hyperostosis (HP:0004493)1.41854956
169Broad thumb (HP:0011304)1.41397859
170Short hallux (HP:0010109)1.40618550
171Anophthalmia (HP:0000528)1.39524795
172Anterior segment dysgenesis (HP:0007700)1.39338862
173Ulnar deviation of the wrist (HP:0003049)1.39245540
174Increased corneal curvature (HP:0100692)1.39088350
175Keratoconus (HP:0000563)1.39088350
176Abnormal number of incisors (HP:0011064)1.39026340

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.32785014
2IRAK32.77212980
3IRAK42.38678648
4MKNK12.35804550
5MAP3K142.31874809
6ARAF2.21716469
7JAK32.18510849
8ERBB32.18071972
9NTRK12.15517992
10LATS12.09200208
11MKNK22.06067627
12STK38L1.99086663
13PASK1.92523154
14FLT31.89961663
15STK161.89936698
16EPHB21.84978586
17DDR21.77388183
18TIE11.73996228
19EIF2AK21.73638699
20PDGFRA1.71830834
21TGFBR11.71074807
22ADRBK21.68595033
23CHUK1.66365515
24INSRR1.64718930
25WNK31.61989340
26YES11.55217117
27FGFR21.51454576
28SRPK11.48033877
29TXK1.47953252
30EEF2K1.46902933
31KIT1.44533160
32MYLK1.41056882
33PTK61.40755971
34TRPM71.39179924
35MAP3K101.38420647
36MAP4K21.33609963
37BTK1.31998681
38STK31.31623097
39CAMK1G1.25661953
40MET1.24591873
41STK41.24373530
42CDK121.21315570
43PTK21.20063826
44IKBKB1.19704232
45CDK71.15648571
46BRD41.14826676
47SIK31.14738265
48NEK91.13091950
49EPHA31.12249580
50ATR1.07877256
51CLK11.06592507
52TRIM281.06461139
53LATS21.03830690
54DYRK21.03768452
55TGFBR21.03603224
56BMPR1B1.03518795
57TEC1.02053768
58TTN1.01889213
59ROCK11.01859106
60BLK1.01775851
61PNCK1.01735765
62NUAK10.99514697
63FRK0.96941226
64RPS6KA40.96805911
65CDC42BPA0.93908902
66NME10.92814585
67PKN20.92566763
68TBK10.90117663
69PINK10.89266737
70PAK40.88932445
71STK240.88498798
72PIK3CG0.87759658
73CSNK1G10.85950215
74CAMK1D0.85135049
75LMTK20.84865507
76ROCK20.83753596
77TYRO30.83672998
78MARK10.83491304
79MAPK150.83320828
80PRKCE0.81212487
81RPS6KB20.76971626
82FER0.76201702
83PAK20.76095004
84TAOK20.76066809
85BRAF0.74266043
86ADRBK10.74122110
87TTK0.73977044
88RIPK10.72931413
89CDK40.72867394
90AKT30.72824767
91CASK0.72717793
92CDK80.70831641
93MTOR0.70019068
94TRIB30.69877426
95NEK10.69513851
96AKT10.68904279
97IKBKE0.67203699
98PRKD20.66908595
99PLK40.65987608
100PIM10.65429947
101PRKCI0.64795574
102BCKDK0.64708385
103CSNK1G30.61851821
104LYN0.61826472
105PLK20.61209604
106BCR0.60979500
107CDK30.60199272
108STK380.59551606
109NEK20.59538375
110IRAK10.59015187
111MAPKAPK50.58957712
112MUSK0.58944132
113CDK60.58175768
114GRK10.57536938
115BMX0.57306946
116LIMK10.57038824
117RPS6KA60.56731841
118TNIK0.56040995
119WNK10.56032847
120PLK10.56017577
121JAK10.55850521
122MAP3K20.55095801
123MAP3K40.54696017
124MAPKAPK30.54566815
125DMPK0.54312347
126ILK0.52719837
127PHKG10.52593342
128PHKG20.52593342
129NLK0.52515231
130ICK0.51696791
131CHEK20.51171332
132CSNK1A1L0.50247917
133DYRK30.49933855
134BRSK20.49588447
135RPS6KL10.49564921
136RPS6KC10.49564921
137TYK20.49302295
138WNK40.48902508
139PIM20.48243200
140FGFR10.48126079
141OBSCN0.48094841
142CDC70.48029032
143PRKD30.46523391
144PAK30.45642523
145SIK10.45475140
146MAPKAPK20.43944808
147AKT20.43200479
148ERBB20.43175455
149MAP3K50.41801523
150PDGFRB0.41759833
151ATM0.41412558
152AURKB0.39073212
153TSSK60.38382351
154RPS6KA20.38172947
155PLK30.37015735
156MAPK30.36670993
157MAPK10.36066716

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053322.36368028
2Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.28993933
3Allograft rejection_Homo sapiens_hsa053302.08618311
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.08582203
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.04266103
6Steroid biosynthesis_Homo sapiens_hsa001001.95978006
7Legionellosis_Homo sapiens_hsa051341.85295577
8Toll-like receptor signaling pathway_Homo sapiens_hsa046201.83063829
9Leishmaniasis_Homo sapiens_hsa051401.80330803
10ECM-receptor interaction_Homo sapiens_hsa045121.80312829
11Herpes simplex infection_Homo sapiens_hsa051681.74915830
12Type I diabetes mellitus_Homo sapiens_hsa049401.74293058
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.73098621
14Basal cell carcinoma_Homo sapiens_hsa052171.72265863
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.67735843
16Notch signaling pathway_Homo sapiens_hsa043301.67341140
17Measles_Homo sapiens_hsa051621.62711119
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.58774144
19Axon guidance_Homo sapiens_hsa043601.58494698
20Protein digestion and absorption_Homo sapiens_hsa049741.56004619
21Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.55703528
22Fanconi anemia pathway_Homo sapiens_hsa034601.53698140
23Base excision repair_Homo sapiens_hsa034101.52757645
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.52633875
25Homologous recombination_Homo sapiens_hsa034401.50706111
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.49663604
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.49172024
28Ribosome_Homo sapiens_hsa030101.48493684
29Cardiac muscle contraction_Homo sapiens_hsa042601.47764535
30TNF signaling pathway_Homo sapiens_hsa046681.41542752
31Autoimmune thyroid disease_Homo sapiens_hsa053201.39330689
32Viral myocarditis_Homo sapiens_hsa054161.38969939
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38807369
34Influenza A_Homo sapiens_hsa051641.35092795
35Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.33554047
36Transcriptional misregulation in cancer_Homo sapiens_hsa052021.30325934
37Hematopoietic cell lineage_Homo sapiens_hsa046401.28315488
38Malaria_Homo sapiens_hsa051441.27838010
39Cell cycle_Homo sapiens_hsa041101.23059285
40Tight junction_Homo sapiens_hsa045301.22429933
41Asthma_Homo sapiens_hsa053101.20452551
42Pertussis_Homo sapiens_hsa051331.18909860
43Spliceosome_Homo sapiens_hsa030401.18608169
44DNA replication_Homo sapiens_hsa030301.18332429
45Toxoplasmosis_Homo sapiens_hsa051451.15584885
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15360557
47Dilated cardiomyopathy_Homo sapiens_hsa054141.14773161
48Hedgehog signaling pathway_Homo sapiens_hsa043401.14019693
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.12646407
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11512348
51Mismatch repair_Homo sapiens_hsa034301.09861207
52HTLV-I infection_Homo sapiens_hsa051661.08029676
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.05517610
54RNA polymerase_Homo sapiens_hsa030201.05014998
55Focal adhesion_Homo sapiens_hsa045101.04758023
56Adherens junction_Homo sapiens_hsa045201.04056975
57Small cell lung cancer_Homo sapiens_hsa052221.02790882
58Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.02513489
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.02506082
60Hippo signaling pathway_Homo sapiens_hsa043901.02347516
61Melanogenesis_Homo sapiens_hsa049161.01924927
62Jak-STAT signaling pathway_Homo sapiens_hsa046301.01224011
63Amoebiasis_Homo sapiens_hsa051461.00183296
64Sulfur relay system_Homo sapiens_hsa041220.98935020
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97366135
66Selenocompound metabolism_Homo sapiens_hsa004500.96829444
67Rheumatoid arthritis_Homo sapiens_hsa053230.96664623
68p53 signaling pathway_Homo sapiens_hsa041150.93919559
69Apoptosis_Homo sapiens_hsa042100.93335772
70TGF-beta signaling pathway_Homo sapiens_hsa043500.93148535
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92339877
72MicroRNAs in cancer_Homo sapiens_hsa052060.90232133
73Osteoclast differentiation_Homo sapiens_hsa043800.89132617
74Tuberculosis_Homo sapiens_hsa051520.88461646
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87345456
76Hepatitis B_Homo sapiens_hsa051610.86491670
77Propanoate metabolism_Homo sapiens_hsa006400.85848842
78Antigen processing and presentation_Homo sapiens_hsa046120.84332017
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82943190
80Proteoglycans in cancer_Homo sapiens_hsa052050.81878365
81Chronic myeloid leukemia_Homo sapiens_hsa052200.81026130
82Arginine and proline metabolism_Homo sapiens_hsa003300.80943736
83Ovarian steroidogenesis_Homo sapiens_hsa049130.80933588
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80776118
85RNA degradation_Homo sapiens_hsa030180.80402881
86Wnt signaling pathway_Homo sapiens_hsa043100.79771163
87Protein export_Homo sapiens_hsa030600.79440109
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79143089
89Huntingtons disease_Homo sapiens_hsa050160.78775226
90mRNA surveillance pathway_Homo sapiens_hsa030150.78533451
91Pathways in cancer_Homo sapiens_hsa052000.78371854
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.77777887
93Salmonella infection_Homo sapiens_hsa051320.77439018
94Phototransduction_Homo sapiens_hsa047440.77436707
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76834239
96One carbon pool by folate_Homo sapiens_hsa006700.76149191
97Basal transcription factors_Homo sapiens_hsa030220.71971875
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.71870944
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71373484
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71051561
101Lysine degradation_Homo sapiens_hsa003100.69245241
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68720703
103Fatty acid elongation_Homo sapiens_hsa000620.67643463
104African trypanosomiasis_Homo sapiens_hsa051430.67260248
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65317761
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64347285
107Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64325435
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64109608
109Chemokine signaling pathway_Homo sapiens_hsa040620.64064544
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63497115
111Butanoate metabolism_Homo sapiens_hsa006500.63482446
112Parkinsons disease_Homo sapiens_hsa050120.60181530
113Epstein-Barr virus infection_Homo sapiens_hsa051690.59629838
114Nucleotide excision repair_Homo sapiens_hsa034200.59229208
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59072529
116Primary immunodeficiency_Homo sapiens_hsa053400.58471042
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57947574
118Oxidative phosphorylation_Homo sapiens_hsa001900.57756199
119Viral carcinogenesis_Homo sapiens_hsa052030.56827205
120Prolactin signaling pathway_Homo sapiens_hsa049170.56755637
121Pyruvate metabolism_Homo sapiens_hsa006200.55994949
122Folate biosynthesis_Homo sapiens_hsa007900.55632871
123cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55005001
124Melanoma_Homo sapiens_hsa052180.54183761
125Alzheimers disease_Homo sapiens_hsa050100.53986623
126Shigellosis_Homo sapiens_hsa051310.53952573
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53916079
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.53802729
129Prostate cancer_Homo sapiens_hsa052150.53597211
130Platelet activation_Homo sapiens_hsa046110.53588771
131N-Glycan biosynthesis_Homo sapiens_hsa005100.52411906
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52357502
133Acute myeloid leukemia_Homo sapiens_hsa052210.51180235
134Arachidonic acid metabolism_Homo sapiens_hsa005900.49754432
135Biosynthesis of amino acids_Homo sapiens_hsa012300.48665778
136Ether lipid metabolism_Homo sapiens_hsa005650.48108825
137Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47448438
1382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46894517
139Metabolic pathways_Homo sapiens_hsa011000.46064822
140Thyroid hormone synthesis_Homo sapiens_hsa049180.45444790
141FoxO signaling pathway_Homo sapiens_hsa040680.45225004
142Non-homologous end-joining_Homo sapiens_hsa034500.44475392
143Central carbon metabolism in cancer_Homo sapiens_hsa052300.43857248
144RNA transport_Homo sapiens_hsa030130.43124664
145Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42899724
146Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42233031
147Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41025820
148Insulin secretion_Homo sapiens_hsa049110.40685043
149Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40437404
150Vascular smooth muscle contraction_Homo sapiens_hsa042700.39768137
151Pyrimidine metabolism_Homo sapiens_hsa002400.39570848
152Linoleic acid metabolism_Homo sapiens_hsa005910.39361299
153Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.38657166
154AMPK signaling pathway_Homo sapiens_hsa041520.38019318
155Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37422107
156Gap junction_Homo sapiens_hsa045400.36900956
157Dorso-ventral axis formation_Homo sapiens_hsa043200.36250847

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