CCDC81

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell-cell recognition (GO:0009988)9.80970138
2binding of sperm to zona pellucida (GO:0007339)9.64843510
3reproduction (GO:0000003)9.45960150
4spermatid development (GO:0007286)8.86321689
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.73027230
6regulation of cilium movement (GO:0003352)8.53526208
7single fertilization (GO:0007338)7.61831700
8male meiosis (GO:0007140)7.01746827
9piRNA metabolic process (GO:0034587)6.96941296
10sperm capacitation (GO:0048240)6.95116873
11synaptonemal complex organization (GO:0070193)6.56625040
12ventricular system development (GO:0021591)6.55938876
13fertilization (GO:0009566)6.29739987
14negative regulation of inclusion body assembly (GO:0090084)6.26434993
15synaptonemal complex assembly (GO:0007130)6.14395343
16spermatogenesis (GO:0007283)5.90895711
17male gamete generation (GO:0048232)5.88560921
18microtubule depolymerization (GO:0007019)5.57451631
19organic cation transport (GO:0015695)5.50132435
20gamete generation (GO:0007276)5.42403976
21regulation of inclusion body assembly (GO:0090083)5.28606810
22calcium ion-dependent exocytosis (GO:0017156)5.27718215
23regulation of microtubule-based movement (GO:0060632)5.14695317
24axoneme assembly (GO:0035082)5.05814131
25cellular process involved in reproduction in multicellular organism (GO:0022412)5.01488155
26cell recognition (GO:0008037)4.95712122
27microtubule severing (GO:0051013)4.94548128
28germ cell development (GO:0007281)4.93747887
29spermatid nucleus differentiation (GO:0007289)4.79904211
30male meiosis I (GO:0007141)4.71368926
31DNA methylation involved in gamete generation (GO:0043046)4.39675201
32left/right pattern formation (GO:0060972)4.35245792
33multicellular organismal reproductive process (GO:0048609)4.28897654
34chromosome organization involved in meiosis (GO:0070192)4.19369852
35intraciliary transport (GO:0042073)4.16177327
36nucleoside diphosphate phosphorylation (GO:0006165)4.12398003
37regulation of mesoderm development (GO:2000380)4.11411668
38protein localization to cilium (GO:0061512)4.10619624
39meiotic nuclear division (GO:0007126)3.98337121
40glycerol ether metabolic process (GO:0006662)3.97252080
41GTP biosynthetic process (GO:0006183)3.97080906
42cilium organization (GO:0044782)3.82876111
43meiosis I (GO:0007127)3.70197921
44ether metabolic process (GO:0018904)3.69593120
45seminiferous tubule development (GO:0072520)3.68039019
46cilium assembly (GO:0042384)3.67491212
47somite rostral/caudal axis specification (GO:0032525)3.67134048
48microtubule-based movement (GO:0007018)3.65031052
49protein polyglutamylation (GO:0018095)3.64376917
50cilium morphogenesis (GO:0060271)3.64053079
51chaperone-mediated protein complex assembly (GO:0051131)3.58529442
52response to pheromone (GO:0019236)3.55907421
53UTP biosynthetic process (GO:0006228)3.49535288
54cellular component assembly involved in morphogenesis (GO:0010927)3.49193752
55cell projection assembly (GO:0030031)3.39721638
56neural tube formation (GO:0001841)3.39224156
57negative regulation of T cell differentiation in thymus (GO:0033085)3.38102054
58multicellular organismal development (GO:0007275)3.37871713
59monoubiquitinated protein deubiquitination (GO:0035520)3.36622829
60left/right axis specification (GO:0070986)3.31718860
61nonmotile primary cilium assembly (GO:0035058)3.30880575
62meiotic cell cycle (GO:0051321)3.28935537
63platelet dense granule organization (GO:0060155)3.27856879
64negative regulation of activin receptor signaling pathway (GO:0032926)3.27195319
65smoothened signaling pathway (GO:0007224)3.26173650
66genitalia morphogenesis (GO:0035112)3.24328046
67determination of left/right symmetry (GO:0007368)3.24028604
68retinal cone cell development (GO:0046549)3.20733322
69photoreceptor cell maintenance (GO:0045494)3.19945604
70regulation of collateral sprouting (GO:0048670)3.19209049
71limb bud formation (GO:0060174)3.19194957
72sequestering of extracellular ligand from receptor (GO:0035581)3.17268941
73UTP metabolic process (GO:0046051)3.15791754
74L-fucose catabolic process (GO:0042355)3.15681748
75fucose catabolic process (GO:0019317)3.15681748
76L-fucose metabolic process (GO:0042354)3.15681748
77centriole assembly (GO:0098534)3.13596287
78chromosome condensation (GO:0030261)3.10076998
79lateral ventricle development (GO:0021670)3.06456460
80primary alcohol catabolic process (GO:0034310)3.06444740
81determination of bilateral symmetry (GO:0009855)3.05811448
82cornea development in camera-type eye (GO:0061303)3.04095546
83specification of symmetry (GO:0009799)3.02377724
84endoderm formation (GO:0001706)3.00253937
85DNA packaging (GO:0006323)2.97983075
86protein K11-linked deubiquitination (GO:0035871)2.97634041
87protein refolding (GO:0042026)2.97567729
88centriole replication (GO:0007099)2.92945955
89response to xenobiotic stimulus (GO:0009410)2.92599742
90one-carbon compound transport (GO:0019755)2.90994204
91microtubule polymerization or depolymerization (GO:0031109)2.89156218
92polyol catabolic process (GO:0046174)2.87388723
93behavioral response to nicotine (GO:0035095)2.87003965
94lactate metabolic process (GO:0006089)2.86065780
95alditol metabolic process (GO:0019400)2.85891631
96glutathione derivative biosynthetic process (GO:1901687)2.81806531
97glutathione derivative metabolic process (GO:1901685)2.81806531
98carnitine transport (GO:0015879)2.80941963
99amino-acid betaine transport (GO:0015838)2.80941963
100DNA deamination (GO:0045006)2.78452505
101glycolytic process (GO:0006096)2.75941473
102negative regulation of organelle assembly (GO:1902116)2.75881303
103retinoic acid metabolic process (GO:0042573)2.75708128
104glycosphingolipid biosynthetic process (GO:0006688)2.74126994
105detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.74065412
106regulation of spindle checkpoint (GO:0090231)2.72193769
107single strand break repair (GO:0000012)2.71522988
108microtubule bundle formation (GO:0001578)2.70510088
109exogenous drug catabolic process (GO:0042738)2.69499899
110carnitine transmembrane transport (GO:1902603)2.69060074
111cellular ketone body metabolic process (GO:0046950)2.68254021
112sexual reproduction (GO:0019953)2.65105267
113lateral sprouting from an epithelium (GO:0060601)2.64997116
114guanosine-containing compound biosynthetic process (GO:1901070)2.63804142
115intra-S DNA damage checkpoint (GO:0031573)2.60039916
116cytoplasmic microtubule organization (GO:0031122)2.56611616
117glycerol metabolic process (GO:0006071)2.55583481
118sensory perception of smell (GO:0007608)2.54961854
119terpenoid biosynthetic process (GO:0016114)2.54144281
120DNA double-strand break processing (GO:0000729)2.52640713
121CTP biosynthetic process (GO:0006241)2.52557299
122CTP metabolic process (GO:0046036)2.52557299
123negative regulation of transcription regulatory region DNA binding (GO:2000678)2.51830573
124nucleus organization (GO:0006997)2.51739508
125positive regulation of macrophage activation (GO:0043032)2.51176925
126signal transduction involved in regulation of gene expression (GO:0023019)2.50472974
127synapsis (GO:0007129)2.50246049
128embryonic axis specification (GO:0000578)2.49801854
129replication fork processing (GO:0031297)2.48446305
130L-ascorbic acid metabolic process (GO:0019852)2.47965518
131ketone body metabolic process (GO:1902224)2.46242074
132sequestering of actin monomers (GO:0042989)2.46191861
133peptidyl-threonine dephosphorylation (GO:0035970)2.45558122
134axis specification (GO:0009798)2.45453994
135aldehyde catabolic process (GO:0046185)2.45259774
136meiotic cell cycle process (GO:1903046)2.43844262
137photoreceptor cell development (GO:0042461)2.43696101
138extracellular regulation of signal transduction (GO:1900115)2.41120389
139extracellular negative regulation of signal transduction (GO:1900116)2.41120389
140sialylation (GO:0097503)2.40633079
141cell migration involved in gastrulation (GO:0042074)2.39202889
142drug catabolic process (GO:0042737)2.37949225
143rRNA catabolic process (GO:0016075)2.36732295
144diterpenoid biosynthetic process (GO:0016102)2.35855377
145retinal rod cell development (GO:0046548)2.35666935
146vitamin transmembrane transport (GO:0035461)2.35037996
147detection of light stimulus involved in visual perception (GO:0050908)2.33008889
148detection of light stimulus involved in sensory perception (GO:0050962)2.33008889
149regulation of hippo signaling (GO:0035330)2.32999140
150dorsal/ventral pattern formation (GO:0009953)2.32776410
151indole-containing compound catabolic process (GO:0042436)2.30725828
152indolalkylamine catabolic process (GO:0046218)2.30725828
153tryptophan catabolic process (GO:0006569)2.30725828
154embryonic pattern specification (GO:0009880)2.28752994
155ethanol metabolic process (GO:0006067)2.28430213
156pyrimidine-containing compound transmembrane transport (GO:0072531)2.28398676
157organelle assembly (GO:0070925)2.27913813
158fusion of sperm to egg plasma membrane (GO:0007342)14.2189460
159cilium or flagellum-dependent cell motility (GO:0001539)13.0516724
160cell wall macromolecule metabolic process (GO:0044036)12.9091431
161cell wall macromolecule catabolic process (GO:0016998)12.9091431
162sperm motility (GO:0030317)12.2768239
163axonemal dynein complex assembly (GO:0070286)11.7563889
164acrosome assembly (GO:0001675)11.4088532
165multicellular organism reproduction (GO:0032504)11.4049011
166epithelial cilium movement (GO:0003351)11.1055164
167sperm-egg recognition (GO:0035036)10.9846563
168plasma membrane fusion (GO:0045026)10.9144907
169acrosome reaction (GO:0007340)10.7051981
170cilium movement (GO:0003341)10.4359480
171motile cilium assembly (GO:0044458)10.1820963

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.44345356
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.36633933
3EZH2_22144423_ChIP-Seq_EOC_Human4.14463817
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.72366160
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.03991758
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.69315719
7* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.66257282
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.63154571
9GBX2_23144817_ChIP-Seq_PC3_Human2.51292960
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.44458148
11IGF1R_20145208_ChIP-Seq_DFB_Human2.35469923
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.30490754
13P300_19829295_ChIP-Seq_ESCs_Human2.27187025
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.13668084
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.13283916
16VDR_22108803_ChIP-Seq_LS180_Human2.11876189
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.08602192
18EWS_26573619_Chip-Seq_HEK293_Human2.06961308
19PIAS1_25552417_ChIP-Seq_VCAP_Human2.06192991
20ZNF274_21170338_ChIP-Seq_K562_Hela2.02302887
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01548171
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.98670221
23SMAD3_21741376_ChIP-Seq_EPCs_Human1.97311341
24EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.96357614
25CBX2_27304074_Chip-Seq_ESCs_Mouse1.96146118
26KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.86994910
27BCAT_22108803_ChIP-Seq_LS180_Human1.86398942
28GATA1_26923725_Chip-Seq_HPCs_Mouse1.82107532
29TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.80639919
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.79700273
31TOP2B_26459242_ChIP-Seq_MCF-7_Human1.74348966
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68502130
33ELK4_26923725_Chip-Seq_MESODERM_Mouse1.67465105
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67056300
35CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.66871443
36RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.65165027
37MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.64635929
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64631897
39* SMAD3_21741376_ChIP-Seq_HESCs_Human1.62023464
40WDR5_24793694_ChIP-Seq_LNCAP_Human1.60913622
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.60532156
42STAT3_23295773_ChIP-Seq_U87_Human1.60180996
43TAL1_26923725_Chip-Seq_HPCs_Mouse1.59892790
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59493027
45NR3C1_21868756_ChIP-Seq_MCF10A_Human1.57615723
46TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.55956300
47STAT1_17558387_ChIP-Seq_HELA_Human1.55607137
48* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55347016
49KDM2B_26808549_Chip-Seq_REH_Human1.54972652
50GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.54857963
51KAP1_22055183_ChIP-Seq_ESCs_Mouse1.54159219
52TCF4_22108803_ChIP-Seq_LS180_Human1.53120615
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.52773028
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.52282678
55CBP_20019798_ChIP-Seq_JUKART_Human1.49667730
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49667730
57REST_21632747_ChIP-Seq_MESCs_Mouse1.49573400
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47406352
59GABP_17652178_ChIP-ChIP_JURKAT_Human1.46294528
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46065785
61* AR_25329375_ChIP-Seq_VCAP_Human1.44687834
62NANOG_19829295_ChIP-Seq_ESCs_Human1.43778609
63SOX2_19829295_ChIP-Seq_ESCs_Human1.43778609
64TAF15_26573619_Chip-Seq_HEK293_Human1.42275196
65* SMAD4_21741376_ChIP-Seq_HESCs_Human1.42044986
66FLI1_21867929_ChIP-Seq_TH2_Mouse1.41543658
67RUNX2_22187159_ChIP-Seq_PCA_Human1.39620067
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37941956
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.37118478
70KLF5_20875108_ChIP-Seq_MESCs_Mouse1.36880112
71RNF2_27304074_Chip-Seq_NSC_Mouse1.35927315
72TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34897277
73SOX2_22085726_ChIP-Seq_NPCs_Mouse1.32800088
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32389682
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31955267
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31779159
77FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30280717
78CRX_20693478_ChIP-Seq_RETINA_Mouse1.29154575
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28889664
80* CDX2_22108803_ChIP-Seq_LS180_Human1.28226006
81GATA3_21867929_ChIP-Seq_CD8_Mouse1.26851159
82LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.26558603
83SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26226137
84* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25031504
85* FOXA1_25329375_ChIP-Seq_VCAP_Human1.25031504
86P53_22387025_ChIP-Seq_ESCs_Mouse1.22463649
87TP53_22573176_ChIP-Seq_HFKS_Human1.22348579
88FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22188112
89ELK1_19687146_ChIP-ChIP_HELA_Human1.20980336
90ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.20935329
91* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.20853560
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20844205
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20844205
94OCT4_18555785_Chip-Seq_ESCs_Mouse1.20841190
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20748455
96CMYC_18555785_Chip-Seq_ESCs_Mouse1.19103493
97MYC_18940864_ChIP-ChIP_HL60_Human1.18542053
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18313833
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17925324
100PRDM14_20953172_ChIP-Seq_ESCs_Human1.17921561
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.17829448
102GF1_26923725_Chip-Seq_HPCs_Mouse1.17160386
103GATA3_21867929_ChIP-Seq_TH1_Mouse1.16670251
104NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16562158
105P300_18555785_Chip-Seq_ESCs_Mouse1.15841867
106FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15433494
107* AR_20517297_ChIP-Seq_VCAP_Human1.15262600
108EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.14095374
109KLF4_18555785_Chip-Seq_ESCs_Mouse1.11339820
110P53_21459846_ChIP-Seq_SAOS-2_Human1.10496723
111OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10276448
112* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09439323
113CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08841932
114SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08812858
115TP53_16413492_ChIP-PET_HCT116_Human1.08553312
116ESRRB_18555785_Chip-Seq_ESCs_Mouse1.08241786
117CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07795457
118CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07598434
119PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.07521189
120SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07358977
121STAT3_18555785_Chip-Seq_ESCs_Mouse1.07023262
122SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.06100227
123ETV1_20927104_ChIP-Seq_GIST48_Human1.05879205
124EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05507855
125FUS_26573619_Chip-Seq_HEK293_Human1.03677936
126SMAD4_21799915_ChIP-Seq_A2780_Human1.03527662
127ER_23166858_ChIP-Seq_MCF-7_Human1.03254874
128SOX2_18555785_Chip-Seq_ESCs_Mouse1.03145697
129IRF1_19129219_ChIP-ChIP_H3396_Human1.02162419
130MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02138028
131NCOR_22424771_ChIP-Seq_293T_Human1.01974252
132PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01968260
133NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01940947
134NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01940947
135E2F1_18555785_Chip-Seq_ESCs_Mouse1.01295852
136SOX9_26525672_Chip-Seq_HEART_Mouse1.00811602
137TP53_18474530_ChIP-ChIP_U2OS_Human0.99961928
138PU1_27457419_Chip-Seq_LIVER_Mouse0.99301585
139HOXB7_26014856_ChIP-Seq_BT474_Human0.99084193
140BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98588476
141RAD21_21589869_ChIP-Seq_MESCs_Mouse0.97206192
142POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97181381
143CTCF_18555785_Chip-Seq_ESCs_Mouse0.96907338
144EST1_17652178_ChIP-ChIP_JURKAT_Human0.96390811
145SMAD4_21741376_ChIP-Seq_EPCs_Human0.95731000
146GF1B_26923725_Chip-Seq_HPCs_Mouse0.95337650
147CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95034822
148RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94969192
149PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93862876
150TCF4_23295773_ChIP-Seq_U87_Human0.93589561
151RUNX1_27457419_Chip-Seq_LIVER_Mouse0.93477490
152ERG_20517297_ChIP-Seq_VCAP_Human0.91621340
153ZFX_18555785_Chip-Seq_ESCs_Mouse0.91449654
154RUNX1_26923725_Chip-Seq_HPCs_Mouse0.91042129
155NMYC_18555785_Chip-Seq_ESCs_Mouse0.89396655
156STAT3_18555785_ChIP-Seq_MESCs_Mouse0.88745148
157AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88172814

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.88457015
2MP0001929_abnormal_gametogenesis5.24458374
3MP0003890_abnormal_embryonic-extraembry4.32174143
4MP0008877_abnormal_DNA_methylation4.11526204
5MP0002653_abnormal_ependyma_morphology3.60237325
6MP0002210_abnormal_sex_determination3.31723954
7MP0002161_abnormal_fertility/fecundity3.16912339
8MP0001145_abnormal_male_reproductive2.80341681
9MP0005394_taste/olfaction_phenotype2.60692615
10MP0005499_abnormal_olfactory_system2.60692615
11MP0000653_abnormal_sex_gland2.46753588
12MP0003195_calcinosis2.46190928
13MP0005623_abnormal_meninges_morphology2.42334824
14MP0000372_irregular_coat_pigmentation2.40333674
15MP0008789_abnormal_olfactory_epithelium2.37767041
16MP0005670_abnormal_white_adipose2.24853994
17MP0004043_abnormal_pH_regulation2.13357104
18MP0005410_abnormal_fertilization15.3259212
19MP0009046_muscle_twitch1.92838274
20MP0002160_abnormal_reproductive_system1.90755837
21MP0001485_abnormal_pinna_reflex1.90158551
22MP0002638_abnormal_pupillary_reflex1.85132001
23MP0006292_abnormal_olfactory_placode1.82827281
24MP0001984_abnormal_olfaction1.78685749
25MP0002277_abnormal_respiratory_mucosa1.77114004
26MP0008872_abnormal_physiological_respon1.61668255
27MP0002938_white_spotting1.61141867
28MP0003119_abnormal_digestive_system1.58914718
29MP0001529_abnormal_vocalization1.50556650
30MP0002282_abnormal_trachea_morphology1.50440893
31MP0002132_abnormal_respiratory_system1.49602151
32MP0003937_abnormal_limbs/digits/tail_de1.45999405
33MP0000383_abnormal_hair_follicle1.45532600
34MP0003283_abnormal_digestive_organ1.40532914
35MP0004233_abnormal_muscle_weight1.40519830
36MP0006054_spinal_hemorrhage1.39331011
37MP0010030_abnormal_orbit_morphology1.38902308
38MP0005645_abnormal_hypothalamus_physiol1.30066442
39MP0004885_abnormal_endolymph1.29547187
40MP0002233_abnormal_nose_morphology1.26953892
41MP0005171_absent_coat_pigmentation1.25856168
42MP0004142_abnormal_muscle_tone1.25287604
43MP0002735_abnormal_chemical_nociception1.23662158
44MP0003646_muscle_fatigue1.23378080
45MP0005084_abnormal_gallbladder_morpholo1.22845958
46MP0008995_early_reproductive_senescence1.22384025
47MP0000049_abnormal_middle_ear1.20625876
48MP0001765_abnormal_ion_homeostasis1.19190207
49MP0003787_abnormal_imprinting1.18722168
50MP0000427_abnormal_hair_cycle1.10627980
51MP0002254_reproductive_system_inflammat1.10457262
52MP0000631_abnormal_neuroendocrine_gland1.09192819
53MP0005647_abnormal_sex_gland1.08880913
54MP0002876_abnormal_thyroid_physiology1.08043137
55MP0003718_maternal_effect1.05286617
56MP0006276_abnormal_autonomic_nervous0.99696899
57MP0000569_abnormal_digit_pigmentation0.98340601
58MP0005377_hearing/vestibular/ear_phenot0.95412388
59MP0003878_abnormal_ear_physiology0.95412388
60MP0005187_abnormal_penis_morphology0.94539097
61MP0004215_abnormal_myocardial_fiber0.94476723
62MP0003806_abnormal_nucleotide_metabolis0.93397572
63MP0005389_reproductive_system_phenotype0.93226196
64MP0002751_abnormal_autonomic_nervous0.91287992
65MP0003137_abnormal_impulse_conducting0.89144068
66MP0003136_yellow_coat_color0.89077991
67MP0005408_hypopigmentation0.88591767
68MP0000516_abnormal_urinary_system0.86824496
69MP0005367_renal/urinary_system_phenotyp0.86824496
70MP0005551_abnormal_eye_electrophysiolog0.84927396
71MP0001970_abnormal_pain_threshold0.84442267
72MP0003950_abnormal_plasma_membrane0.83488310
73MP0002928_abnormal_bile_duct0.81549894
74MP0002102_abnormal_ear_morphology0.81170125
75MP0003943_abnormal_hepatobiliary_system0.80494389
76MP0010678_abnormal_skin_adnexa0.79917158
77MP0002736_abnormal_nociception_after0.78666703
78MP0002234_abnormal_pharynx_morphology0.78295067
79MP0002109_abnormal_limb_morphology0.78237544
80MP0001286_abnormal_eye_development0.77272092
81MP0001968_abnormal_touch/_nociception0.75598868
82MP0002837_dystrophic_cardiac_calcinosis0.75518390
83MP0005423_abnormal_somatic_nervous0.73897252
84MP0005075_abnormal_melanosome_morpholog0.73036947
85MP0002184_abnormal_innervation0.72536535
86MP0002084_abnormal_developmental_patter0.71905254
87MP0000647_abnormal_sebaceous_gland0.71850442
88MP0003755_abnormal_palate_morphology0.71038068
89MP0003186_abnormal_redox_activity0.69842106
90MP0004133_heterotaxia0.69714200
91MP0008058_abnormal_DNA_repair0.68616169
92MP0001440_abnormal_grooming_behavior0.62846651
93MP0005253_abnormal_eye_physiology0.61802684
94MP0004270_analgesia0.61471186
95MP0002572_abnormal_emotion/affect_behav0.61417166
96MP0003329_amyloid_beta_deposits0.60756015
97MP0003635_abnormal_synaptic_transmissio0.59624886
98MP0003011_delayed_dark_adaptation0.54250476
99MP0003115_abnormal_respiratory_system0.54181316
100MP0002557_abnormal_social/conspecific_i0.53739091
101MP0003633_abnormal_nervous_system0.53407147
102MP0005636_abnormal_mineral_homeostasis0.51909476
103MP0004145_abnormal_muscle_electrophysio0.51887983
104MP0002064_seizures0.50426793
105MP0002063_abnormal_learning/memory/cond0.49053477
106MP0009745_abnormal_behavioral_response0.49013864
107MP0004859_abnormal_synaptic_plasticity0.48432156
108MP0002152_abnormal_brain_morphology0.47154515
109MP0001486_abnormal_startle_reflex0.46657606
110MP0002272_abnormal_nervous_system0.45782918
111MP0008057_abnormal_DNA_replication0.44410330
112MP0001986_abnormal_taste_sensitivity0.43234013
113MP0001324_abnormal_eye_pigmentation0.43185740
114MP0004036_abnormal_muscle_relaxation0.43068097
115MP0000358_abnormal_cell_content/0.42434430
116MP0005391_vision/eye_phenotype0.42206158
117MP0003699_abnormal_female_reproductive0.42058666
118MP0003861_abnormal_nervous_system0.40390930
119MP0003879_abnormal_hair_cell0.39782604
120MP0001293_anophthalmia0.38795977
121MP0005388_respiratory_system_phenotype0.37871560
122MP0002133_abnormal_respiratory_system0.37871560
123MP0002734_abnormal_mechanical_nocicepti0.36949183
124MP0009115_abnormal_fat_cell0.36878251
125MP0002229_neurodegeneration0.36684128
126MP0008569_lethality_at_weaning0.36387759
127MP0004811_abnormal_neuron_physiology0.36121168
128MP0004742_abnormal_vestibular_system0.36072342
129MP0006072_abnormal_retinal_apoptosis0.35086437
130MP0005646_abnormal_pituitary_gland0.35013002
131MP0003631_nervous_system_phenotype0.34901375
132MP0003634_abnormal_glial_cell0.34253096
133MP0002067_abnormal_sensory_capabilities0.33884255
134MP0002752_abnormal_somatic_nervous0.33683749
135MP0008004_abnormal_stomach_pH0.33670900
136MP0002269_muscular_atrophy0.33539620
137MP0003880_abnormal_central_pattern0.31298498
138MP0003045_fibrosis0.31153537
139MP0000534_abnormal_ureter_morphology0.31028503
140MP0002882_abnormal_neuron_morphology0.30953978
141MP0003786_premature_aging0.30574149
142MP0005195_abnormal_posterior_eye0.30184479
143MP0001270_distended_abdomen0.29618355
144MP0001963_abnormal_hearing_physiology0.28501638
145MP0001119_abnormal_female_reproductive0.27796376
146MP0004019_abnormal_vitamin_homeostasis0.27231921
147MP0001764_abnormal_homeostasis0.27189432
148MP0003942_abnormal_urinary_system0.26943645
149MP0001727_abnormal_embryo_implantation0.26625071
150MP0003948_abnormal_gas_homeostasis0.25641738
151MP0001501_abnormal_sleep_pattern0.25572321
152MP0000955_abnormal_spinal_cord0.25367642
153MP0001851_eye_inflammation0.25051362
154MP0008875_abnormal_xenobiotic_pharmacok0.23951312
155MP0000026_abnormal_inner_ear0.23078651
156MP0009250_abnormal_appendicular_skeleto0.22892412
157MP0000778_abnormal_nervous_system0.22596595

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.64687016
2Abnormal respiratory motile cilium morphology (HP:0005938)9.64687016
3Abnormal ciliary motility (HP:0012262)9.10268787
4Rhinitis (HP:0012384)8.52702173
5Chronic bronchitis (HP:0004469)7.46074604
6Nasal polyposis (HP:0100582)6.15714257
7Infertility (HP:0000789)5.93740301
8Abnormality of the nasal mucosa (HP:0000433)5.07502735
9Bronchiectasis (HP:0002110)4.93204611
10Bronchitis (HP:0012387)4.44007713
11Nephronophthisis (HP:0000090)4.09735046
12Male infertility (HP:0003251)3.85395903
13Recurrent sinusitis (HP:0011108)3.59635234
14Recurrent otitis media (HP:0000403)3.18159596
15Medial flaring of the eyebrow (HP:0010747)3.17216608
16Abnormality of the renal medulla (HP:0100957)3.09538475
17Molar tooth sign on MRI (HP:0002419)2.89346816
18Abnormality of midbrain morphology (HP:0002418)2.89346816
19Tubulointerstitial nephritis (HP:0001970)2.86014979
20Abnormal spermatogenesis (HP:0008669)2.67401845
21Sclerocornea (HP:0000647)2.54532411
22Recurrent bronchitis (HP:0002837)2.42629785
23Gait imbalance (HP:0002141)2.39866579
24Congenital primary aphakia (HP:0007707)2.37542406
25Pancreatic fibrosis (HP:0100732)2.35449812
26Chronic sinusitis (HP:0011109)2.30062860
27Congenital stationary night blindness (HP:0007642)2.28769131
28Tubular atrophy (HP:0000092)2.27092111
29Tubulointerstitial abnormality (HP:0001969)2.24630472
30Furrowed tongue (HP:0000221)2.20947065
31Postaxial foot polydactyly (HP:0001830)2.19477770
32Aplasia/Hypoplasia of the spleen (HP:0010451)2.18505329
33Abnormal rod and cone electroretinograms (HP:0008323)2.18489070
34Asplenia (HP:0001746)2.16391767
35Preaxial hand polydactyly (HP:0001177)2.15133376
36True hermaphroditism (HP:0010459)2.13605285
37Nephrogenic diabetes insipidus (HP:0009806)2.07621009
38Congenital hepatic fibrosis (HP:0002612)2.05064383
39Absent rod-and cone-mediated responses on ERG (HP:0007688)2.03146021
40Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.5682188
41Absent/shortened dynein arms (HP:0200106)12.4344584
42Dynein arm defect of respiratory motile cilia (HP:0012255)12.4344584
43Abnormal respiratory motile cilium physiology (HP:0012261)10.4733963
44Abdominal situs inversus (HP:0003363)1.96362703
45Abnormality of abdominal situs (HP:0011620)1.96362703
46Chronic otitis media (HP:0000389)1.94612242
47Azoospermia (HP:0000027)1.93997382
48Intestinal atresia (HP:0011100)1.90001059
49Impulsivity (HP:0100710)1.89812574
50Type II lissencephaly (HP:0007260)1.89152460
51Bile duct proliferation (HP:0001408)1.88603533
52Abnormal biliary tract physiology (HP:0012439)1.88603533
53Fibular hypoplasia (HP:0003038)1.86709997
54Gonadotropin excess (HP:0000837)1.85659194
55Narrow forehead (HP:0000341)1.83946764
56Supernumerary spleens (HP:0009799)1.83546988
57Genital tract atresia (HP:0001827)1.82125189
58Stage 5 chronic kidney disease (HP:0003774)1.81753576
59Abolished electroretinogram (ERG) (HP:0000550)1.80999512
60Abnormality of dentin (HP:0010299)1.80415748
61Postaxial hand polydactyly (HP:0001162)1.79872724
62Attenuation of retinal blood vessels (HP:0007843)1.79337555
63Abnormality of permanent molar morphology (HP:0011071)1.78855311
64Abnormality of the dental root (HP:0006486)1.78855311
65Taurodontia (HP:0000679)1.78855311
66Aplasia/Hypoplasia of the lens (HP:0008063)1.78592440
67Progressive inability to walk (HP:0002505)1.78285043
68Aplasia/Hypoplasia of the tongue (HP:0010295)1.78024135
69Cystic liver disease (HP:0006706)1.76668856
70Vaginal atresia (HP:0000148)1.75656693
71Poor coordination (HP:0002370)1.75024092
72Median cleft lip (HP:0000161)1.74641713
73Anophthalmia (HP:0000528)1.73960358
74Tubulointerstitial fibrosis (HP:0005576)1.71868121
75Oculomotor apraxia (HP:0000657)1.70280441
76Absent speech (HP:0001344)1.70013523
77Abnormality of macular pigmentation (HP:0008002)1.69656534
78Facial cleft (HP:0002006)1.69495792
79Aplasia/Hypoplasia of the tibia (HP:0005772)1.69396877
80Disproportionate short-trunk short stature (HP:0003521)1.69245644
81Abnormality of molar morphology (HP:0011070)1.67169995
82Abnormality of molar (HP:0011077)1.67169995
83Polyuria (HP:0000103)1.66940628
84Decreased circulating renin level (HP:0003351)1.66702897
85Abnormality of the dental pulp (HP:0006479)1.65731493
86Increased corneal curvature (HP:0100692)1.65109220
87Keratoconus (HP:0000563)1.65109220
88Dandy-Walker malformation (HP:0001305)1.61227971
89Oligodactyly (hands) (HP:0001180)1.59889158
90Decreased central vision (HP:0007663)1.59720893
91Pancreatic cysts (HP:0001737)1.59472759
92Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.58446807
93Hypoplasia of the fovea (HP:0007750)1.57850633
94Aplasia/Hypoplasia of the fovea (HP:0008060)1.57850633
95Dyschromatopsia (HP:0007641)1.57811899
96Aganglionic megacolon (HP:0002251)1.55792131
97Short ribs (HP:0000773)1.55359674
98J-shaped sella turcica (HP:0002680)1.53739353
99Microglossia (HP:0000171)1.52730244
100Occipital encephalocele (HP:0002085)1.52529901
101Bony spicule pigmentary retinopathy (HP:0007737)1.51538770
102Abnormality of the lower motor neuron (HP:0002366)1.51171934
103Bifid tongue (HP:0010297)1.48841599
104Polydipsia (HP:0001959)1.48639970
105Abnormal drinking behavior (HP:0030082)1.48639970
106Multicystic kidney dysplasia (HP:0000003)1.48464313
107Abnormal pancreas size (HP:0012094)1.47999535
108Methylmalonic acidemia (HP:0002912)1.47843891
109Optic nerve hypoplasia (HP:0000609)1.46486530
110Abnormality of the labia minora (HP:0012880)1.46309777
111Short tibia (HP:0005736)1.45995877
112Labial hypoplasia (HP:0000066)1.44512280
113Astigmatism (HP:0000483)1.44064819
114Bell-shaped thorax (HP:0001591)1.43143824
115Retinitis pigmentosa (HP:0000510)1.42863559
116Abnormality of renal excretion (HP:0011036)1.42840191
117Renal dysplasia (HP:0000110)1.41971183
118Prominent nasal bridge (HP:0000426)1.41900103
119Highly arched eyebrow (HP:0002553)1.41533496
120Hypoplasia of the capital femoral epiphysis (HP:0003090)1.41409625
121Abnormality of the renal cortex (HP:0011035)1.40789890
122Cholecystitis (HP:0001082)1.40597278
123Abnormal gallbladder physiology (HP:0012438)1.40597278
124Spastic tetraparesis (HP:0001285)1.40372455
125Chronic hepatic failure (HP:0100626)1.38954153
126Hemiparesis (HP:0001269)1.34753856
127Abnormality of saccadic eye movements (HP:0000570)1.33921318
128Abnormality of ocular smooth pursuit (HP:0000617)1.30473974
129Amyotrophic lateral sclerosis (HP:0007354)1.26916537
130Heterotopia (HP:0002282)1.25964563
131Nephropathy (HP:0000112)1.25352994
132Short thorax (HP:0010306)1.19572605
133Aplasia/Hypoplasia of the fibula (HP:0006492)1.19227930
134Male pseudohermaphroditism (HP:0000037)1.19077094
135Neurofibrillary tangles (HP:0002185)1.18814469
136Absent frontal sinuses (HP:0002688)1.17182245
137Deformed sella turcica (HP:0002681)1.16281518
138Impaired smooth pursuit (HP:0007772)1.15167164
139Retinal dysplasia (HP:0007973)1.14886298
140Broad distal phalanx of finger (HP:0009836)1.14318836
141Anencephaly (HP:0002323)1.14254567
142Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.10815185
143Absent epiphyses (HP:0010577)1.10815185
144Abnormal urine output (HP:0012590)1.10561232
145Constricted visual fields (HP:0001133)1.10072559

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.52487299
2PDK38.52487299
3PDK25.48572887
4TESK15.06566568
5PRKD34.24666104
6FRK3.87381830
7TRIM283.51318745
8ICK3.50531639
9PNCK3.45742118
10BMPR1B3.34748979
11ACVR1B3.33082576
12MST43.08713734
13MAP4K23.00472102
14PTK2B2.35274292
15BCR2.31964614
16WNK42.15446591
17STK392.13190799
18NUAK12.11368106
19CASK1.99930927
20MAPK151.94383597
21ADRBK21.87796519
22ERBB41.75648350
23INSRR1.64825320
24MAPK131.54916949
25STK381.54821311
26PBK1.52316927
27TAOK31.41663727
28MKNK21.33196118
29PLK21.18498241
30ZAK1.18257579
31TGFBR11.18058404
32NME11.14657805
33ADRBK11.14426541
34SIK31.13442441
35PAK31.11074580
36DYRK1B1.09072480
37NEK21.07924404
38OXSR11.06893280
39MAPKAPK31.06285614
40PDK11.00976811
41TYRO30.97190496
42WNK10.95567145
43CSNK1G10.95438024
44LMTK20.91624121
45CSNK1G20.91518474
46EIF2AK30.90701497
47MAP3K120.85735429
48PRKCE0.85081931
49IRAK10.83510698
50TLK10.83508929
51BCKDK0.81141635
52DYRK20.80540052
53FER0.77491184
54CAMK1G0.76777216
55CSNK1G30.75652564
56FLT30.72433267
57NTRK20.70664216
58TIE10.70330090
59PLK30.68289528
60EPHA20.67793527
61DYRK30.67433485
62PRKCI0.64375893
63CSNK1A1L0.64230155
64MKNK10.64202975
65TEC0.63457075
66VRK10.63070692
67NLK0.61845849
68WEE10.59726221
69CHEK20.58733172
70STK30.58604450
71DAPK20.55862292
72MUSK0.51863762
73MAP2K60.50912260
74PRKCG0.50269212
75TRPM70.50057235
76PDPK10.49397161
77CCNB10.48418488
78TESK20.48322857
79MYLK0.47222567
80CDK120.44732499
81MAPKAPK50.41996439
82PASK0.40738092
83TTK0.38875525
84AKT30.38320755
85RIPK40.37967288
86STK38L0.36664149
87NEK60.35482819
88PAK10.34371642
89MARK30.34090756
90IRAK20.33063498
91MARK10.33000320
92BRSK20.32809842
93CHEK10.32510076
94PLK40.32145072
95CAMKK10.31746470
96CSNK1A10.31399374
97FGFR20.31330586
98PINK10.30721882
99CDK30.29049736
100DYRK1A0.28927290
101ROCK10.28662162
102TSSK60.28399826
103PAK20.27845797
104VRK20.27044532
105MAP3K40.26956989
106EEF2K0.26944200
107OBSCN0.26880794
108TXK0.26624243
109STK240.26588603
110ATM0.26579237
111PKN10.25465194
112LIMK10.25443815
113GRK10.24236074
114ERBB20.23770378
115GRK50.23181514
116CAMK2A0.22032617
117MARK20.21971159
118ABL10.21956671
119IGF1R0.21761684
120TAF10.20951718
121MAP2K10.20448310
122PRKAA10.19267752
123NTRK30.18897132
124MAP2K70.18855010
125MINK10.18140741
126BRSK10.18130284
127MTOR0.18055460
128PRKG10.17204834
129YES10.17053130
130PRKCZ0.14268690
131STK110.13613040
132PRKCQ0.13382589
133PRKACG0.13044889
134RPS6KB10.12298565
135BRAF0.12067221
136AURKA0.11407154
137CDK150.11348297
138ATR0.10014702
139GSK3B0.09418173
140CDK180.09176174
141CSNK1D0.08960764
142WNK30.08922873
143ERBB30.08326605
144GRK70.08302326
145PRKACA0.08197114
146PLK10.08183482
147TNIK0.07861281
148EPHA40.06830997
149CDK11A0.06717476
150PRKCA0.06673778
151LATS10.05823913
152PAK40.05819643
153EGFR0.05721865
154CDK140.05644509
155STK100.05577421
156PRKCB0.05333994
157RPS6KA10.05074100
158RPS6KA30.04704575
159GSK3A0.04617561
160PAK60.04556736
161CSNK2A10.04355155
162RPS6KA20.04218416
163MAPK80.04205174
164MAPK100.04204837
165PRKDC0.04196545

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.92859747
2Fatty acid biosynthesis_Homo sapiens_hsa000613.85076455
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.82475609
4Pyruvate metabolism_Homo sapiens_hsa006203.36518213
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.17853023
6Propanoate metabolism_Homo sapiens_hsa006402.69185241
7Protein export_Homo sapiens_hsa030602.68298760
8Butanoate metabolism_Homo sapiens_hsa006502.68156439
9Phototransduction_Homo sapiens_hsa047442.53186699
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.48376782
11Glucagon signaling pathway_Homo sapiens_hsa049222.47126225
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.38194754
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.30841147
14Linoleic acid metabolism_Homo sapiens_hsa005912.26841923
15Basal transcription factors_Homo sapiens_hsa030222.14943629
16Huntingtons disease_Homo sapiens_hsa050162.14367590
17Caffeine metabolism_Homo sapiens_hsa002322.10250010
18Glycosaminoglycan degradation_Homo sapiens_hsa005312.00306668
19Carbohydrate digestion and absorption_Homo sapiens_hsa049731.94310644
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.92238581
21Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.90479066
22Amphetamine addiction_Homo sapiens_hsa050311.86046047
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83841608
24Glycerolipid metabolism_Homo sapiens_hsa005611.83667463
25Peroxisome_Homo sapiens_hsa041461.83530969
26beta-Alanine metabolism_Homo sapiens_hsa004101.80307089
27PPAR signaling pathway_Homo sapiens_hsa033201.77425215
28Oocyte meiosis_Homo sapiens_hsa041141.76815806
29Pentose phosphate pathway_Homo sapiens_hsa000301.76560384
30Dorso-ventral axis formation_Homo sapiens_hsa043201.75810835
31Histidine metabolism_Homo sapiens_hsa003401.72514294
32Selenocompound metabolism_Homo sapiens_hsa004501.72424897
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.71831112
34Homologous recombination_Homo sapiens_hsa034401.65466043
35Cardiac muscle contraction_Homo sapiens_hsa042601.63285769
36Nitrogen metabolism_Homo sapiens_hsa009101.58862368
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.57491949
38Renin secretion_Homo sapiens_hsa049241.55632011
39Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.54878832
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.54452313
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.53020228
42Proteasome_Homo sapiens_hsa030501.50877403
43Oxidative phosphorylation_Homo sapiens_hsa001901.50702383
44Retinol metabolism_Homo sapiens_hsa008301.49247638
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46712956
46Mineral absorption_Homo sapiens_hsa049781.46559928
47Glycerophospholipid metabolism_Homo sapiens_hsa005641.46032000
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.44428674
49Fanconi anemia pathway_Homo sapiens_hsa034601.35424804
50Tryptophan metabolism_Homo sapiens_hsa003801.31428346
51Non-homologous end-joining_Homo sapiens_hsa034501.30703239
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.29597537
53Ether lipid metabolism_Homo sapiens_hsa005651.28019573
54Fructose and mannose metabolism_Homo sapiens_hsa000511.27516890
55Steroid biosynthesis_Homo sapiens_hsa001001.27373055
56Collecting duct acid secretion_Homo sapiens_hsa049661.25033316
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.23931466
58Taste transduction_Homo sapiens_hsa047421.20861093
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.17576615
60Insulin secretion_Homo sapiens_hsa049111.16680479
61RNA polymerase_Homo sapiens_hsa030201.14306936
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.13358820
63Parkinsons disease_Homo sapiens_hsa050121.12760733
64Steroid hormone biosynthesis_Homo sapiens_hsa001401.11737972
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09322388
66Nicotine addiction_Homo sapiens_hsa050331.07948691
67Long-term potentiation_Homo sapiens_hsa047201.07886976
68Synaptic vesicle cycle_Homo sapiens_hsa047211.05177431
69Primary bile acid biosynthesis_Homo sapiens_hsa001201.03919593
70Carbon metabolism_Homo sapiens_hsa012001.03062250
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02267470
72Calcium signaling pathway_Homo sapiens_hsa040201.01490605
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00741208
74Olfactory transduction_Homo sapiens_hsa047401.00110314
75Basal cell carcinoma_Homo sapiens_hsa052170.99587198
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98087283
77RNA degradation_Homo sapiens_hsa030180.97023690
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.95968875
79Purine metabolism_Homo sapiens_hsa002300.93862737
80Estrogen signaling pathway_Homo sapiens_hsa049150.93702193
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.93202605
82Salivary secretion_Homo sapiens_hsa049700.93084474
83Circadian entrainment_Homo sapiens_hsa047130.92409730
84Nucleotide excision repair_Homo sapiens_hsa034200.91607181
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89359539
86Hedgehog signaling pathway_Homo sapiens_hsa043400.86589599
87Fatty acid elongation_Homo sapiens_hsa000620.85385850
88Gastric acid secretion_Homo sapiens_hsa049710.84760258
89Thyroid hormone synthesis_Homo sapiens_hsa049180.82640976
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82596440
91Fatty acid metabolism_Homo sapiens_hsa012120.81997532
92Antigen processing and presentation_Homo sapiens_hsa046120.80508686
93Tyrosine metabolism_Homo sapiens_hsa003500.79579641
94Glutathione metabolism_Homo sapiens_hsa004800.78961194
95mRNA surveillance pathway_Homo sapiens_hsa030150.75357634
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73641397
97Hippo signaling pathway_Homo sapiens_hsa043900.71790900
98Fat digestion and absorption_Homo sapiens_hsa049750.71758665
99One carbon pool by folate_Homo sapiens_hsa006700.71275220
100Chemical carcinogenesis_Homo sapiens_hsa052040.69875882
101Glutamatergic synapse_Homo sapiens_hsa047240.68850502
102Renin-angiotensin system_Homo sapiens_hsa046140.68345215
103Bile secretion_Homo sapiens_hsa049760.68227323
104Fatty acid degradation_Homo sapiens_hsa000710.67840675
105Regulation of autophagy_Homo sapiens_hsa041400.65881343
106Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65481143
107TGF-beta signaling pathway_Homo sapiens_hsa043500.65382352
108cAMP signaling pathway_Homo sapiens_hsa040240.64381825
109Circadian rhythm_Homo sapiens_hsa047100.64271825
110Arachidonic acid metabolism_Homo sapiens_hsa005900.63721353
111Inositol phosphate metabolism_Homo sapiens_hsa005620.62751398
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61836236
113Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58925531
114Serotonergic synapse_Homo sapiens_hsa047260.58762629
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57886538
116Cocaine addiction_Homo sapiens_hsa050300.57665262
117Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57625502
118Pancreatic secretion_Homo sapiens_hsa049720.54613247
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.53277774
120Mismatch repair_Homo sapiens_hsa034300.53267843
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.52816658
122Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52481335
123Biosynthesis of amino acids_Homo sapiens_hsa012300.50600549
124Asthma_Homo sapiens_hsa053100.50600429
125Protein digestion and absorption_Homo sapiens_hsa049740.47149048
126ABC transporters_Homo sapiens_hsa020100.46471293
127Phenylalanine metabolism_Homo sapiens_hsa003600.45919259
128Intestinal immune network for IgA production_Homo sapiens_hsa046720.45371024
129Dopaminergic synapse_Homo sapiens_hsa047280.43284483
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43106495
131Morphine addiction_Homo sapiens_hsa050320.42315018
132RNA transport_Homo sapiens_hsa030130.42186972
133Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40586778
134Metabolic pathways_Homo sapiens_hsa011000.39232192
135Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.38399748
136Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35786952
137Pyrimidine metabolism_Homo sapiens_hsa002400.35109457
138Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34400075
139Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34307611
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33559232
141Oxytocin signaling pathway_Homo sapiens_hsa049210.33301022
142AMPK signaling pathway_Homo sapiens_hsa041520.33075240
143Endocytosis_Homo sapiens_hsa041440.32917579
144Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32170794
145Wnt signaling pathway_Homo sapiens_hsa043100.31559971
146Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31084839
147Ovarian steroidogenesis_Homo sapiens_hsa049130.29602190
148Central carbon metabolism in cancer_Homo sapiens_hsa052300.27916532
149Systemic lupus erythematosus_Homo sapiens_hsa053220.24809828
150N-Glycan biosynthesis_Homo sapiens_hsa005100.24544611
151Alzheimers disease_Homo sapiens_hsa050100.24312338
152GABAergic synapse_Homo sapiens_hsa047270.22708925
153Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.22635176
154Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22503308
155VEGF signaling pathway_Homo sapiens_hsa043700.19719939
156Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19505475

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