CCDC82

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G8.34059816
2melanin biosynthetic process (GO:0042438)6.05458826
3positive regulation of gamma-delta T cell activation (GO:0046645)5.74822575
4secondary metabolite biosynthetic process (GO:0044550)5.52958121
5melanin metabolic process (GO:0006582)5.48909874
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.29910434
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.29910434
8antigen processing and presentation of endogenous antigen (GO:0019883)5.05756083
9response to pheromone (GO:0019236)5.01840103
10inositol phosphate catabolic process (GO:0071545)4.76337863
11DNA double-strand break processing (GO:0000729)4.36253955
12neutrophil activation involved in immune response (GO:0002283)4.31728453
13negative regulation of cell killing (GO:0031342)4.29427683
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.29427683
15pyrimidine nucleobase catabolic process (GO:0006208)4.19800394
16phosphorylated carbohydrate dephosphorylation (GO:0046838)4.19772431
17inositol phosphate dephosphorylation (GO:0046855)4.19772431
18regulation of B cell receptor signaling pathway (GO:0050855)4.12869734
19regulation of DNA endoreduplication (GO:0032875)4.09633324
20centriole replication (GO:0007099)4.06407753
21defense response to protozoan (GO:0042832)4.02268701
22microtubule depolymerization (GO:0007019)3.92476169
23neural tube formation (GO:0001841)3.91878856
24presynaptic membrane assembly (GO:0097105)3.88975323
25positive regulation of B cell differentiation (GO:0045579)3.86867295
26leukocyte aggregation (GO:0070486)3.85365797
27negative thymic T cell selection (GO:0045060)3.85223038
28positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.84696100
29regulation of interleukin-12 biosynthetic process (GO:0045075)3.84032660
30regulation of gamma-delta T cell differentiation (GO:0045586)3.83268418
31intraciliary transport (GO:0042073)3.82148119
32negative regulation of DNA-dependent DNA replication (GO:2000104)3.80478916
33regulation of gamma-delta T cell activation (GO:0046643)3.80456469
34negative T cell selection (GO:0043383)3.80021468
35interferon-gamma production (GO:0032609)3.78366543
36response to protozoan (GO:0001562)3.77004687
37epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.76825096
38regulation of B cell differentiation (GO:0045577)3.67852045
39polyol catabolic process (GO:0046174)3.58172427
40epithelial cilium movement (GO:0003351)3.56613797
41resolution of meiotic recombination intermediates (GO:0000712)3.53366597
42neutrophil activation (GO:0042119)3.51607001
43T cell migration (GO:0072678)3.50525874
44cullin deneddylation (GO:0010388)3.46901986
45retinal rod cell development (GO:0046548)3.45912757
46cellular response to zinc ion (GO:0071294)3.45608991
47natural killer cell mediated immunity (GO:0002228)3.44297247
48natural killer cell mediated cytotoxicity (GO:0042267)3.44297247
49regulation of alpha-beta T cell proliferation (GO:0046640)3.39525135
50positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.38618145
51regulation of meiosis I (GO:0060631)3.38374678
52presynaptic membrane organization (GO:0097090)3.37344622
53microtubule anchoring (GO:0034453)3.33356341
54regulation of interferon-beta biosynthetic process (GO:0045357)3.32404564
55acrosome reaction (GO:0007340)3.30510323
56mast cell activation (GO:0045576)3.29182215
57nucleobase catabolic process (GO:0046113)3.26182341
58response to interleukin-15 (GO:0070672)3.25890792
59positive thymic T cell selection (GO:0045059)3.25837141
60B cell receptor signaling pathway (GO:0050853)3.25801278
61myeloid dendritic cell activation (GO:0001773)3.24753119
62positive regulation by symbiont of host defense response (GO:0052509)3.23864705
63modulation by symbiont of host defense response (GO:0052031)3.23864705
64modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.23864705
65modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.23864705
66positive regulation by organism of defense response of other organism involved in symbiotic interact3.23864705
67modulation by symbiont of host immune response (GO:0052553)3.23864705
68microtubule polymerization or depolymerization (GO:0031109)3.23801798
69regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.20101789
70granulocyte activation (GO:0036230)3.20028060
71melanosome organization (GO:0032438)3.19537438
72NIK/NF-kappaB signaling (GO:0038061)3.19072716
73immunoglobulin mediated immune response (GO:0016064)3.18446795
74cellular response to interleukin-15 (GO:0071350)3.18151700
75regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.17719588
76signal peptide processing (GO:0006465)3.17557982
77positive regulation of alpha-beta T cell proliferation (GO:0046641)3.16733609
78positive regulation of granulocyte differentiation (GO:0030854)3.14556789
79protein localization to cilium (GO:0061512)3.13099520
80cilium morphogenesis (GO:0060271)3.12063813
81neutrophil mediated immunity (GO:0002446)3.11275212
82platelet dense granule organization (GO:0060155)3.08308597
83positive regulation of antigen processing and presentation (GO:0002579)3.08145961
84positive regulation of macrophage differentiation (GO:0045651)3.07437073
85synapsis (GO:0007129)3.06734805
86cilium organization (GO:0044782)3.05917168
87negative regulation of neurological system process (GO:0031645)3.02954808
88cilium assembly (GO:0042384)3.01845735
89pigment granule organization (GO:0048753)3.01688982
90detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.01110559
91cilium movement (GO:0003341)3.00767764
92protein deneddylation (GO:0000338)3.00686392
93myeloid cell activation involved in immune response (GO:0002275)2.98255716
94mature B cell differentiation (GO:0002335)2.98228516
95replication fork processing (GO:0031297)2.96409216
96regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.95960275
97positive T cell selection (GO:0043368)2.95551396
98ketone body metabolic process (GO:1902224)2.94959875
99positive regulation of interferon-alpha production (GO:0032727)2.93628755
100response to type I interferon (GO:0034340)2.93336814
101postsynaptic membrane organization (GO:0001941)2.92750476
102myeloid dendritic cell differentiation (GO:0043011)2.92728951
103phenol-containing compound biosynthetic process (GO:0046189)2.92415701
104nonmotile primary cilium assembly (GO:0035058)2.92172760
105definitive hemopoiesis (GO:0060216)2.91416693
106interferon-gamma-mediated signaling pathway (GO:0060333)2.88234159
107T cell selection (GO:0045058)2.85630800
108regulation of interferon-alpha production (GO:0032647)2.85477363
109type I interferon signaling pathway (GO:0060337)2.84871487
110cellular response to type I interferon (GO:0071357)2.84871487
111leukocyte cell-cell adhesion (GO:0007159)2.84248564
112positive regulation of interleukin-2 production (GO:0032743)2.84164103
113natural killer cell activation (GO:0030101)2.82466693
114B cell homeostasis (GO:0001782)2.82318029
115developmental pigmentation (GO:0048066)2.82179220
116response to muramyl dipeptide (GO:0032495)2.82038482
117positive regulation of isotype switching (GO:0045830)2.81503012
118neurotransmitter-gated ion channel clustering (GO:0072578)2.80292256
119necroptotic process (GO:0070266)2.79901617
120negative regulation of DNA recombination (GO:0045910)2.79824274
121glycosphingolipid biosynthetic process (GO:0006688)2.78323433
122B cell proliferation (GO:0042100)2.78321709
123thymic T cell selection (GO:0045061)2.78285671
124proteasome assembly (GO:0043248)2.78167323
125axoneme assembly (GO:0035082)2.77970831
126antigen receptor-mediated signaling pathway (GO:0050851)2.77943288
127kinetochore organization (GO:0051383)2.77915085
128centrosome duplication (GO:0051298)2.77631897
129hepatocyte apoptotic process (GO:0097284)2.77003016
130regulation of antigen processing and presentation (GO:0002577)2.76226942
131neuron cell-cell adhesion (GO:0007158)2.75451671
132respiratory burst (GO:0045730)2.75388785
133regulation of cilium movement (GO:0003352)2.74350982
134kinetochore assembly (GO:0051382)2.71417039
135cellular response to interferon-beta (GO:0035458)2.70970838
136histone H2A acetylation (GO:0043968)2.70939702
137piRNA metabolic process (GO:0034587)2.70868290
138T cell lineage commitment (GO:0002360)2.70797104
139behavioral response to ethanol (GO:0048149)2.70455804
140macrophage activation involved in immune response (GO:0002281)2.70430525
141CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.69642077
142recombinational repair (GO:0000725)2.67879665
143leukocyte degranulation (GO:0043299)2.66690016
144regulation of mast cell activation (GO:0033003)2.66005670
145mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.65872407
146positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.65872407
147cellular extravasation (GO:0045123)2.65305240
148lymphocyte homeostasis (GO:0002260)2.65015863
149microtubule nucleation (GO:0007020)2.64736817
150intra-S DNA damage checkpoint (GO:0031573)2.64631795
151negative regulation of interleukin-12 production (GO:0032695)2.64031954
152programmed necrotic cell death (GO:0097300)2.63295344
153N-terminal protein amino acid acetylation (GO:0006474)2.63266367
154olfactory bulb development (GO:0021772)2.62099337
155double-strand break repair via homologous recombination (GO:0000724)2.61914035
156melanosome transport (GO:0032402)2.61118976
157inner ear receptor stereocilium organization (GO:0060122)2.61101725
158T cell costimulation (GO:0031295)2.61064395
159regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.60611965
160centriole assembly (GO:0098534)2.60270652
161regulation of regulatory T cell differentiation (GO:0045589)2.60002628
162mast cell degranulation (GO:0043303)2.59988210
163mast cell activation involved in immune response (GO:0002279)2.59988210
164myeloid leukocyte activation (GO:0002274)2.59897192
165regulation of T cell tolerance induction (GO:0002664)2.59634720
166establishment of protein localization to Golgi (GO:0072600)2.59529382
167myeloid leukocyte mediated immunity (GO:0002444)2.59367532
168lymphocyte costimulation (GO:0031294)2.59140513
169regulation of development, heterochronic (GO:0040034)2.58279066
170protein targeting to Golgi (GO:0000042)2.57847886
171T cell receptor signaling pathway (GO:0050852)2.57679738
172regulation of T cell receptor signaling pathway (GO:0050856)2.57428662
173retinal ganglion cell axon guidance (GO:0031290)2.57196317
174CENP-A containing nucleosome assembly (GO:0034080)2.56953252
175establishment of melanosome localization (GO:0032401)2.56367112
176mitotic G2 DNA damage checkpoint (GO:0007095)2.55662466
177protein prenylation (GO:0018342)2.55615791
178prenylation (GO:0097354)2.55615791
179synaptic transmission, cholinergic (GO:0007271)2.55436934
180production of molecular mediator involved in inflammatory response (GO:0002532)2.54660750
181positive regulation of DNA recombination (GO:0045911)2.54342629
182pigment granule transport (GO:0051904)2.53923702
183C4-dicarboxylate transport (GO:0015740)2.53887207
184regulation of hexokinase activity (GO:1903299)2.53144717
185regulation of glucokinase activity (GO:0033131)2.53144717
186protein localization to synapse (GO:0035418)2.52226252
187protein K6-linked ubiquitination (GO:0085020)2.51124094
188histone exchange (GO:0043486)2.50038923
189establishment of pigment granule localization (GO:0051905)2.49691279
190chromatin remodeling at centromere (GO:0031055)2.49411516
191G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.49205099
192regulation of mitotic spindle checkpoint (GO:1903504)2.47437236
193regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.47437236
194male meiosis (GO:0007140)2.47323731
195protein neddylation (GO:0045116)2.46934673
196sister chromatid cohesion (GO:0007062)2.45557340
197mitotic G2/M transition checkpoint (GO:0044818)2.45191876
198cilium or flagellum-dependent cell motility (GO:0001539)2.44047405
199photoreceptor cell development (GO:0042461)2.43463068
200sympathetic nervous system development (GO:0048485)2.43123980

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.26970036
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.13191517
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.08506016
4E2F7_22180533_ChIP-Seq_HELA_Human4.93362396
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.66671245
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.16773511
7IRF8_21731497_ChIP-ChIP_J774_Mouse4.10744017
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.70822294
9SCL_19346495_ChIP-Seq_HPC-7_Human3.40053585
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.22362592
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.18431892
12SALL1_21062744_ChIP-ChIP_HESCs_Human3.06388187
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.05333887
14GBX2_23144817_ChIP-Seq_PC3_Human2.99246801
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.93105654
16FUS_26573619_Chip-Seq_HEK293_Human2.88578624
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.87514582
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.84339709
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.83610933
20ZNF274_21170338_ChIP-Seq_K562_Hela2.79570877
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.77269470
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.74194195
23RUNX_20019798_ChIP-Seq_JUKART_Human2.63479807
24STAT4_19710469_ChIP-ChIP_TH1__Mouse2.57834296
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.56896807
26TAF15_26573619_Chip-Seq_HEK293_Human2.54813472
27VDR_22108803_ChIP-Seq_LS180_Human2.52855537
28IGF1R_20145208_ChIP-Seq_DFB_Human2.50836494
29MYB_26560356_Chip-Seq_TH2_Human2.42776850
30EWS_26573619_Chip-Seq_HEK293_Human2.39206183
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30744105
32P300_19829295_ChIP-Seq_ESCs_Human2.27687651
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.25419477
34CTBP2_25329375_ChIP-Seq_LNCAP_Human2.22722863
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.21730168
36SPI1_23547873_ChIP-Seq_NB4_Human2.18853265
37GATA1_22025678_ChIP-Seq_K562_Human2.12251719
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.11545378
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.11216735
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.10355238
41MYB_26560356_Chip-Seq_TH1_Human2.06257495
42SMAD_19615063_ChIP-ChIP_OVARY_Human2.05348687
43* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.99971198
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98731961
45MAF_26560356_Chip-Seq_TH1_Human1.98624549
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.94391878
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.88068110
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.87137327
49KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.84759985
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.83975437
51BRD4_27068464_Chip-Seq_AML-cells_Mouse1.81797386
52* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.81592235
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80464881
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.77929100
55SMAD4_21799915_ChIP-Seq_A2780_Human1.77302707
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.75218144
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72443425
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.72026065
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71778646
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.70715610
61ER_23166858_ChIP-Seq_MCF-7_Human1.67417718
62VDR_21846776_ChIP-Seq_THP-1_Human1.67283139
63GATA3_27048872_Chip-Seq_THYMUS_Human1.67139508
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.66586969
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65921654
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.63370544
67LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.63231906
68SPI1_23127762_ChIP-Seq_K562_Human1.62994360
69MYC_22102868_ChIP-Seq_BL_Human1.62887982
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.62087620
71VDR_24763502_ChIP-Seq_THP-1_Human1.61176441
72EZH2_22144423_ChIP-Seq_EOC_Human1.60716375
73PU_27001747_Chip-Seq_BMDM_Mouse1.59707592
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59148820
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.57803372
76HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.56765419
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.56756020
78CBP_20019798_ChIP-Seq_JUKART_Human1.56273112
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56273112
80NFE2_27457419_Chip-Seq_LIVER_Mouse1.55322694
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.55147991
82FOXM1_23109430_ChIP-Seq_U2OS_Human1.53623499
83STAT3_23295773_ChIP-Seq_U87_Human1.53163717
84UTX_26944678_Chip-Seq_JUKART_Human1.52097636
85RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.51115153
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50575319
87LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.48922252
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48200108
89EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.48176554
90TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46592976
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46247711
92AR_25329375_ChIP-Seq_VCAP_Human1.45526286
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45073572
94P53_22387025_ChIP-Seq_ESCs_Mouse1.44275420
95STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44264548
96ELF1_17652178_ChIP-ChIP_JURKAT_Human1.43363092
97SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.42742530
98HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42617476
99GABP_17652178_ChIP-ChIP_JURKAT_Human1.42376767
100E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39849366
101TCF4_23295773_ChIP-Seq_U87_Human1.39793834
102CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.37670990
103RBPJ_22232070_ChIP-Seq_NCS_Mouse1.37425612
104E2F4_17652178_ChIP-ChIP_JURKAT_Human1.37391038
105BCAT_22108803_ChIP-Seq_LS180_Human1.36860141
106EST1_17652178_ChIP-ChIP_JURKAT_Human1.36569836
107CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.34504160
108RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.33779540
109TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33033720
110E2F1_18555785_Chip-Seq_ESCs_Mouse1.32956751
111PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32898755
112TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32857731
113GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32680266
114GATA3_26560356_Chip-Seq_TH2_Human1.32170522
115ELK1_19687146_ChIP-ChIP_HELA_Human1.31243146
116CRX_20693478_ChIP-Seq_RETINA_Mouse1.31022596
117SUZ12_18555785_Chip-Seq_ESCs_Mouse1.30269696
118TAL1_26923725_Chip-Seq_HPCs_Mouse1.29845127
119* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28224659
120KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27835767
121CMYC_18555785_Chip-Seq_ESCs_Mouse1.26902963
122JUN_21703547_ChIP-Seq_K562_Human1.26649103
123CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.26553104
124TCF7_22412390_ChIP-Seq_EML_Mouse1.26517730
125SOX2_19829295_ChIP-Seq_ESCs_Human1.26029359
126NANOG_19829295_ChIP-Seq_ESCs_Human1.26029359
127TCF4_22108803_ChIP-Seq_LS180_Human1.23889347
128VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23631823
129RUNX2_22187159_ChIP-Seq_PCA_Human1.22937867
130TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20937522
131NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20717595
132P300_18555785_Chip-Seq_ESCs_Mouse1.20602759
133STAT3_18555785_Chip-Seq_ESCs_Mouse1.20057939
134FLI1_21867929_ChIP-Seq_TH2_Mouse1.19792018
135EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.19730606
136NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18138269
137OCT4_21477851_ChIP-Seq_ESCs_Mouse1.18065280
138GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17938554
139NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17341690
140POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17051316
141TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17051316
142PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16478613
143PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16180817
144RNF2_27304074_Chip-Seq_NSC_Mouse1.14829306
145GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13289630
146NOTCH1_21737748_ChIP-Seq_TLL_Human1.12913283
147SOX2_18555785_Chip-Seq_ESCs_Mouse1.12848337
148ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12752049
149PRDM14_20953172_ChIP-Seq_ESCs_Human1.12292662
150GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12185766
151CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11791876
152OCT4_18555785_Chip-Seq_ESCs_Mouse1.11538511
153TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10266025
154SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09473796
155KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.08506152
156TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07943057
157E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07458824
158FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07270170
159SOX2_21211035_ChIP-Seq_LN229_Gbm1.06033850
160GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05786909
161CBX2_27304074_Chip-Seq_ESCs_Mouse1.05744130
162EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05259513
163NMYC_18555785_Chip-Seq_ESCs_Mouse1.05197957
164KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04342717
165GATA1_19941827_ChIP-Seq_MEL_Mouse1.02810119
166VDR_24787735_ChIP-Seq_THP-1_Human1.00837006
167CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00755448
168MAF_26560356_Chip-Seq_TH2_Human0.99455658
169STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97630258
170CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96887974
171E2F1_21310950_ChIP-Seq_MCF-7_Human0.96690156
172GATA2_19941826_ChIP-Seq_K562_Human0.95870292
173FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93716811
174PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93074645
175SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92707743
176GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91203599
177CIITA_25753668_ChIP-Seq_RAJI_Human0.90849900
178CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87642972
179BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.86605579
180NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85508232
181CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84555909
182FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.84346649
183* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.78973404
184KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.78797043
185VDR_23849224_ChIP-Seq_CD4+_Human0.76438973
186GATA1_19941826_ChIP-Seq_K562_Human0.76095802
187* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.74471942
188ETS1_22383799_ChIP-Seq_G1ME_Mouse0.70025356
189CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.69295316
190KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.69044131
191FLI1_27457419_Chip-Seq_LIVER_Mouse0.67702926
192KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.61905441
193KDM2B_26808549_Chip-Seq_DND41_Human0.61672800
194CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.60222103

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation5.99718222
2MP0001835_abnormal_antigen_presentation4.14129538
3MP0000569_abnormal_digit_pigmentation3.82155522
4MP0004510_myositis3.80072336
5MP0005671_abnormal_response_to3.50782773
6MP0005171_absent_coat_pigmentation3.44818972
7MP0002166_altered_tumor_susceptibility3.40345270
8MP0003136_yellow_coat_color3.35044549
9MP0002102_abnormal_ear_morphology3.31198305
10MP0002006_tumorigenesis3.11270632
11MP0001800_abnormal_humoral_immune2.78250908
12MP0009785_altered_susceptibility_to2.72134542
13MP0003880_abnormal_central_pattern2.65515054
14MP0005000_abnormal_immune_tolerance2.64915445
15MP0003763_abnormal_thymus_physiology2.63554646
16MP0000685_abnormal_immune_system2.60280712
17MP0003436_decreased_susceptibility_to2.59508728
18MP0002452_abnormal_antigen_presenting2.53882914
19MP0002420_abnormal_adaptive_immunity2.38326069
20MP0002723_abnormal_immune_serum2.37337165
21MP0001819_abnormal_immune_cell2.36062364
22MP0001790_abnormal_immune_system2.34620047
23MP0005387_immune_system_phenotype2.34620047
24MP0002419_abnormal_innate_immunity2.33612722
25MP0005025_abnormal_response_to2.33417917
26MP0002396_abnormal_hematopoietic_system2.28491743
27MP0002148_abnormal_hypersensitivity_rea2.22990241
28MP0002398_abnormal_bone_marrow2.22975432
29MP0005253_abnormal_eye_physiology2.19158319
30MP0005464_abnormal_platelet_physiology2.18205806
31MP0001984_abnormal_olfaction2.17229670
32MP0003724_increased_susceptibility_to2.15241051
33MP0008877_abnormal_DNA_methylation2.13033703
34MP0002638_abnormal_pupillary_reflex2.08069195
35MP0002009_preneoplasia2.07401686
36MP0004808_abnormal_hematopoietic_stem2.06599002
37MP0003300_gastrointestinal_ulcer2.01762636
38MP0001324_abnormal_eye_pigmentation1.98716631
39MP0002822_catalepsy1.96872624
40MP0003303_peritoneal_inflammation1.95096134
41MP0002405_respiratory_system_inflammati1.93161903
42MP0000716_abnormal_immune_system1.92720463
43MP0002938_white_spotting1.91790671
44MP0001873_stomach_inflammation1.85751020
45MP0005174_abnormal_tail_pigmentation1.83106370
46MP0005551_abnormal_eye_electrophysiolog1.80480627
47MP0006072_abnormal_retinal_apoptosis1.76456230
48MP0003195_calcinosis1.75043425
49MP0005397_hematopoietic_system_phenotyp1.73637619
50MP0001545_abnormal_hematopoietic_system1.73637619
51MP0001529_abnormal_vocalization1.73329619
52MP0006082_CNS_inflammation1.72589500
53MP0000689_abnormal_spleen_morphology1.72179346
54MP0009046_muscle_twitch1.71440379
55MP0009697_abnormal_copulation1.68795338
56MP0002736_abnormal_nociception_after1.67990152
57MP0010155_abnormal_intestine_physiology1.67789545
58MP0002722_abnormal_immune_system1.67225882
59MP0001845_abnormal_inflammatory_respons1.64032289
60MP0003787_abnormal_imprinting1.63170109
61MP0002429_abnormal_blood_cell1.63034016
62MP0001853_heart_inflammation1.62199672
63MP0003121_genomic_imprinting1.61562438
64MP0009333_abnormal_splenocyte_physiolog1.59940466
65MP0006292_abnormal_olfactory_placode1.58006156
66MP0003806_abnormal_nucleotide_metabolis1.57501713
67MP0003172_abnormal_lysosome_physiology1.54195735
68MP0003279_aneurysm1.52525620
69MP0003866_abnormal_defecation1.51976804
70MP0004947_skin_inflammation1.50855113
71MP0000703_abnormal_thymus_morphology1.47480154
72MP0003656_abnormal_erythrocyte_physiolo1.44697021
73MP0000778_abnormal_nervous_system1.43996661
74MP0000015_abnormal_ear_pigmentation1.40340516
75MP0001486_abnormal_startle_reflex1.39701045
76MP0006276_abnormal_autonomic_nervous1.39297130
77MP0003448_altered_tumor_morphology1.39176282
78MP0002272_abnormal_nervous_system1.38666673
79MP0009745_abnormal_behavioral_response1.37902709
80MP0009278_abnormal_bone_marrow1.37607554
81MP0001968_abnormal_touch/_nociception1.37249309
82MP0004885_abnormal_endolymph1.36843724
83MP0000465_gastrointestinal_hemorrhage1.34952548
84MP0002090_abnormal_vision1.33641552
85MP0004859_abnormal_synaptic_plasticity1.33265856
86MP0005310_abnormal_salivary_gland1.33060126
87MP0000858_altered_metastatic_potential1.27500964
88MP0005386_behavior/neurological_phenoty1.26793219
89MP0004924_abnormal_behavior1.26793219
90MP0004142_abnormal_muscle_tone1.26377331
91MP0005084_abnormal_gallbladder_morpholo1.25872151
92MP0002877_abnormal_melanocyte_morpholog1.24682086
93MP0001533_abnormal_skeleton_physiology1.24019042
94MP0003122_maternal_imprinting1.23084493
95MP0010307_abnormal_tumor_latency1.22179658
96MP0002735_abnormal_chemical_nociception1.20575630
97MP0005367_renal/urinary_system_phenotyp1.17198599
98MP0000516_abnormal_urinary_system1.17198599
99MP0004043_abnormal_pH_regulation1.15876556
100MP0009764_decreased_sensitivity_to1.14882348
101MP0002572_abnormal_emotion/affect_behav1.13570455
102MP0003183_abnormal_peptide_metabolism1.12695756
103MP0005248_abnormal_Harderian_gland1.12437442
104MP0000490_abnormal_crypts_of1.12342285
105MP0003635_abnormal_synaptic_transmissio1.10173129
106MP0002067_abnormal_sensory_capabilities1.09486902
107MP0000343_altered_response_to1.09302964
108MP0005075_abnormal_melanosome_morpholog1.07099273
109MP0005423_abnormal_somatic_nervous1.06980594
110MP0005187_abnormal_penis_morphology1.06275750
111MP0002063_abnormal_learning/memory/cond1.05583742
112MP0003943_abnormal_hepatobiliary_system1.04964821
113MP0008057_abnormal_DNA_replication1.04386941
114MP0003890_abnormal_embryonic-extraembry1.02762961
115MP0008469_abnormal_protein_level1.01588924
116MP0004147_increased_porphyrin_level0.99835481
117MP0002095_abnormal_skin_pigmentation0.99422964
118MP0005391_vision/eye_phenotype0.99185778
119MP0002751_abnormal_autonomic_nervous0.98847437
120MP0002933_joint_inflammation0.98170222
121MP0000427_abnormal_hair_cycle0.97960702
122MP0005076_abnormal_cell_differentiation0.97649152
123MP0005195_abnormal_posterior_eye0.97470631
124MP0003718_maternal_effect0.97298040
125MP0003646_muscle_fatigue0.97101763
126MP0010094_abnormal_chromosome_stability0.97076702
127MP0002064_seizures0.96593869
128MP0004270_analgesia0.96565449
129MP0002075_abnormal_coat/hair_pigmentati0.96288867
130MP0005058_abnormal_lysosome_morphology0.95283864
131MP0004133_heterotaxia0.95263188
132MP0002229_neurodegeneration0.94911785
133MP0002019_abnormal_tumor_incidence0.94260047
134MP0003045_fibrosis0.93267983
135MP0010352_gastrointestinal_tract_polyps0.92828656
136MP0002998_abnormal_bone_remodeling0.92345449
137MP0005645_abnormal_hypothalamus_physiol0.92282147
138MP0003698_abnormal_male_reproductive0.91341604
139MP0010386_abnormal_urinary_bladder0.89750318
140MP0000955_abnormal_spinal_cord0.89680263
141MP0002557_abnormal_social/conspecific_i0.87424180
142MP0002234_abnormal_pharynx_morphology0.87411616
143MP0001929_abnormal_gametogenesis0.85468224
144MP0002752_abnormal_somatic_nervous0.85362490
145MP0001293_anophthalmia0.84621379
146MP0002928_abnormal_bile_duct0.84025059
147MP0000631_abnormal_neuroendocrine_gland0.83662883
148MP0000371_diluted_coat_color0.83523106
149MP0004811_abnormal_neuron_physiology0.83283819
150MP0000767_abnormal_smooth_muscle0.83055841
151MP0002882_abnormal_neuron_morphology0.81974250
152MP0002734_abnormal_mechanical_nocicepti0.81676605
153MP0001186_pigmentation_phenotype0.79447580
154MP0008789_abnormal_olfactory_epithelium0.78816578
155MP0004381_abnormal_hair_follicle0.78262193
156MP0000647_abnormal_sebaceous_gland0.77871332
157MP0002184_abnormal_innervation0.77101624
158MP0008007_abnormal_cellular_replicative0.75945688
159MP0003091_abnormal_cell_migration0.75258412
160MP0001501_abnormal_sleep_pattern0.73395137
161MP0001188_hyperpigmentation0.72136619
162MP0001851_eye_inflammation0.71989207
163MP0005166_decreased_susceptibility_to0.71363873
164MP0004215_abnormal_myocardial_fiber0.70914032
165MP0001970_abnormal_pain_threshold0.70228966
166MP0008058_abnormal_DNA_repair0.70039261
167MP0002210_abnormal_sex_determination0.69884516
168MP0003077_abnormal_cell_cycle0.69798297
169MP0003567_abnormal_fetal_cardiomyocyte0.68977600
170MP0005408_hypopigmentation0.68520341
171MP0003693_abnormal_embryo_hatching0.68129319
172MP0009763_increased_sensitivity_to0.67527620
173MP0003828_pulmonary_edema0.66724327
174MP0001879_abnormal_lymphatic_vessel0.66079900
175MP0005394_taste/olfaction_phenotype0.65445930
176MP0005499_abnormal_olfactory_system0.65445930
177MP0001905_abnormal_dopamine_level0.64555403
178MP0001919_abnormal_reproductive_system0.63691907
179MP0002177_abnormal_outer_ear0.63431356
180MP0003186_abnormal_redox_activity0.62967206
181MP0003075_altered_response_to0.60803487
182MP0006054_spinal_hemorrhage0.59837717
183MP0001663_abnormal_digestive_system0.59775754
184MP0005023_abnormal_wound_healing0.59692423
185MP0000749_muscle_degeneration0.59176676
186MP0001986_abnormal_taste_sensitivity0.58893434
187MP0003566_abnormal_cell_adhesion0.58317983

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.44046069
2Recurrent bacterial skin infections (HP:0005406)4.98314057
3Eczematoid dermatitis (HP:0000976)4.13962896
4Intestinal atresia (HP:0011100)4.10521452
5Myositis (HP:0100614)3.98219199
6IgM deficiency (HP:0002850)3.90879856
7Recurrent fungal infections (HP:0002841)3.85180411
8Mediastinal lymphadenopathy (HP:0100721)3.70483567
9Recurrent viral infections (HP:0004429)3.64234958
10Recurrent bronchitis (HP:0002837)3.62754192
11Optic neuritis (HP:0100653)3.58828309
12Retrobulbar optic neuritis (HP:0100654)3.58828309
13T lymphocytopenia (HP:0005403)3.57838628
14Elevated erythrocyte sedimentation rate (HP:0003565)3.52721118
15Hypoplasia of the fovea (HP:0007750)3.51215736
16Aplasia/Hypoplasia of the fovea (HP:0008060)3.51215736
17Aplasia/Hypoplasia of the macula (HP:0008059)3.49380086
18Abnormality of T cell number (HP:0011839)3.45640753
19Recurrent skin infections (HP:0001581)3.45337514
20Pancreatic cysts (HP:0001737)3.40176118
21Chronic mucocutaneous candidiasis (HP:0002728)3.38686262
22Recurrent cutaneous fungal infections (HP:0011370)3.38686262
23Periodontitis (HP:0000704)3.37434700
24Abnormality of the fovea (HP:0000493)3.35804292
25Chronic otitis media (HP:0000389)3.35720255
26Orchitis (HP:0100796)3.35044560
27Blue irides (HP:0000635)3.26583945
28Abnormal delayed hypersensitivity skin test (HP:0002963)3.23446467
29Abnormality of the fingertips (HP:0001211)3.23072405
30Pancreatic fibrosis (HP:0100732)3.22836475
31Aplasia/Hypoplasia affecting the retina (HP:0008061)3.19043607
32Molar tooth sign on MRI (HP:0002419)3.19006202
33Abnormality of midbrain morphology (HP:0002418)3.19006202
34Medial flaring of the eyebrow (HP:0010747)3.18294136
35Meningitis (HP:0001287)3.13562091
36Abnormality of T cells (HP:0002843)3.12087954
37Agammaglobulinemia (HP:0004432)3.10127022
38Thyroiditis (HP:0100646)3.09230241
39True hermaphroditism (HP:0010459)3.06379606
40Vasculitis (HP:0002633)3.06065859
41Panhypogammaglobulinemia (HP:0003139)3.05786321
42Gingivitis (HP:0000230)3.01628197
43Lymphopenia (HP:0001888)2.94965993
44Gait imbalance (HP:0002141)2.92348769
45Prolonged bleeding time (HP:0003010)2.90626239
46Inflammation of the large intestine (HP:0002037)2.89326626
47IgA deficiency (HP:0002720)2.87279857
48IgG deficiency (HP:0004315)2.86572900
49Cellulitis (HP:0100658)2.86165695
50Nephronophthisis (HP:0000090)2.85796323
51Abnormal auditory evoked potentials (HP:0006958)2.84583819
52Severe combined immunodeficiency (HP:0004430)2.84189448
53Congenital stationary night blindness (HP:0007642)2.79341568
54Abnormality of cells of the lymphoid lineage (HP:0012140)2.78231117
55Congenital primary aphakia (HP:0007707)2.74208459
56Spontaneous hematomas (HP:0007420)2.73696452
57Petechiae (HP:0000967)2.70913523
58Long clavicles (HP:0000890)2.69114340
59Abnormality of B cell number (HP:0010975)2.66238153
60B lymphocytopenia (HP:0010976)2.66238153
61Ocular albinism (HP:0001107)2.65576229
62Median cleft lip (HP:0000161)2.64904133
63Gastrointestinal inflammation (HP:0004386)2.64805820
64Abnormality of T cell physiology (HP:0011840)2.64579897
65Stomatitis (HP:0010280)2.64053628
66Patchy hypopigmentation of hair (HP:0011365)2.63708963
67Autoimmune thrombocytopenia (HP:0001973)2.62408137
68Thrombocytosis (HP:0001894)2.61958203
69Gingival bleeding (HP:0000225)2.58363499
70Colitis (HP:0002583)2.58356387
71Absent/shortened dynein arms (HP:0200106)2.56955267
72Dynein arm defect of respiratory motile cilia (HP:0012255)2.56955267
73Postaxial foot polydactyly (HP:0001830)2.56014365
74Abnormality of the prostate (HP:0008775)2.55658234
75Combined immunodeficiency (HP:0005387)2.55482240
76Nephrogenic diabetes insipidus (HP:0009806)2.53718641
77Encephalitis (HP:0002383)2.53711329
78Chronic diarrhea (HP:0002028)2.53291352
79Pulmonary infiltrates (HP:0002113)2.53108693
80Eosinophilia (HP:0001880)2.52261263
81Papilledema (HP:0001085)2.51840411
82Iris hypopigmentation (HP:0007730)2.51302736
83Gastrointestinal stroma tumor (HP:0100723)2.51158008
84Abnormality of the renal medulla (HP:0100957)2.43869365
85Epistaxis (HP:0000421)2.43102885
86White forelock (HP:0002211)2.42086885
87Postaxial hand polydactyly (HP:0001162)2.41555683
88Astigmatism (HP:0000483)2.40929178
89Hypoplasia of the thymus (HP:0000778)2.40729178
90Epidermoid cyst (HP:0200040)2.40218215
91Leukocytosis (HP:0001974)2.39333675
92Obstructive lung disease (HP:0006536)2.39208335
93Chronic obstructive pulmonary disease (HP:0006510)2.39208335
94Supernumerary spleens (HP:0009799)2.37830778
95Abnormal platelet volume (HP:0011876)2.37128800
96Arterial thrombosis (HP:0004420)2.36492511
97Febrile seizures (HP:0002373)2.35970204
98Recurrent gram-negative bacterial infections (HP:0005420)2.35836393
99Prostate neoplasm (HP:0100787)2.34587895
100Generalized hypopigmentation (HP:0007513)2.34259835
101Abnormality of eosinophils (HP:0001879)2.34201281
102Clubbing of toes (HP:0100760)2.33961200
103Chronic hepatic failure (HP:0100626)2.32297605
104Genital tract atresia (HP:0001827)2.31356825
105Osteomyelitis (HP:0002754)2.31344590
106Abnormality of macrophages (HP:0004311)2.30786290
107Hemoptysis (HP:0002105)2.30675695
108Abnormality of chromosome stability (HP:0003220)2.30267176
109Increased IgE level (HP:0003212)2.28304511
110Granulocytopenia (HP:0001913)2.27649003
111Decreased central vision (HP:0007663)2.26108393
112Basal ganglia calcification (HP:0002135)2.25865409
113Oligodactyly (hands) (HP:0001180)2.25529102
114Abnormal respiratory motile cilium morphology (HP:0005938)2.24834780
115Abnormal respiratory epithelium morphology (HP:0012253)2.24834780
116Keratoconjunctivitis sicca (HP:0001097)2.24796010
117Myelodysplasia (HP:0002863)2.23924447
118Tubulointerstitial nephritis (HP:0001970)2.23815106
119Abnormal ciliary motility (HP:0012262)2.22754104
120Leukopenia (HP:0001882)2.20108539
121Hyperventilation (HP:0002883)2.18622592
122Abnormality of the renal cortex (HP:0011035)2.18389845
123Lymphoma (HP:0002665)2.18010947
124Acute myeloid leukemia (HP:0004808)2.17498136
125Abnormality of macular pigmentation (HP:0008002)2.17395692
126Nasal polyposis (HP:0100582)2.16601067
127Abnormal lung lobation (HP:0002101)2.16065784
128Vaginal atresia (HP:0000148)2.15105632
129Absent frontal sinuses (HP:0002688)2.15004900
130Renal cortical cysts (HP:0000803)2.13080938
131Congenital sensorineural hearing impairment (HP:0008527)2.12785837
132Drooling (HP:0002307)2.12398338
133Volvulus (HP:0002580)2.11906591
134Gastrointestinal atresia (HP:0002589)2.11901573
135Absent speech (HP:0001344)2.08717813
136Abnormality of the labia minora (HP:0012880)2.07467729
137Abnormality of the nasal mucosa (HP:0000433)2.07293182
138Freckling (HP:0001480)2.03877411
139Limb dystonia (HP:0002451)2.03261366
140Bifid tongue (HP:0010297)2.01055094
141Gaze-evoked nystagmus (HP:0000640)2.00241399
142Aplasia/Hypoplasia of the uvula (HP:0010293)1.99787876
143Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.99217531
144Albinism (HP:0001022)1.98944090
145Keratoconjunctivitis (HP:0001096)1.98738041
146Sloping forehead (HP:0000340)1.98550465
147Abnormality of the ileum (HP:0001549)1.98309678
148Focal motor seizures (HP:0011153)1.98087558
149Hematochezia (HP:0002573)1.97104908
150Inappropriate behavior (HP:0000719)1.97064197
151Recurrent pneumonia (HP:0006532)1.96925097
152Glomerulopathy (HP:0100820)1.96805354
153Bronchitis (HP:0012387)1.96654127
154Emphysema (HP:0002097)1.96614110
155Progressive inability to walk (HP:0002505)1.96557150
156Recurrent sinusitis (HP:0011108)1.95163911
157Congenital hepatic fibrosis (HP:0002612)1.94822512
158Viral hepatitis (HP:0006562)1.94301881
159Small hand (HP:0200055)1.94228777
160Meckel diverticulum (HP:0002245)1.92318698
161Limb-girdle muscle atrophy (HP:0003797)1.91924373
162Amyotrophic lateral sclerosis (HP:0007354)1.91691710
163Excessive salivation (HP:0003781)1.90756876
164Atrophy/Degeneration involving motor neurons (HP:0007373)1.90647512
165Hypothermia (HP:0002045)1.89345454
166Abnormal respiratory motile cilium physiology (HP:0012261)1.88652180
167Cutaneous melanoma (HP:0012056)1.88612118
168Pustule (HP:0200039)1.87391779
169Generalized hypopigmentation of hair (HP:0011358)1.86692735
170Abnormality of the hip-girdle musculature (HP:0001445)1.86573325
171Abnormality of the musculature of the pelvis (HP:0001469)1.86573325
172Fibular hypoplasia (HP:0003038)1.86313963
173Impaired platelet aggregation (HP:0003540)1.86243475
174Abnormal platelet function (HP:0011869)1.86243475
175Aplasia/Hypoplasia of the tibia (HP:0005772)1.84669334
176Cystic liver disease (HP:0006706)1.84449384
177Specific learning disability (HP:0001328)1.84117237
178Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.83496546
179Small intestinal stenosis (HP:0012848)1.82828272
180Duodenal stenosis (HP:0100867)1.82828272
181Poor coordination (HP:0002370)1.82189353
182Abnormality of the corticospinal tract (HP:0002492)1.82051684
183Lissencephaly (HP:0001339)1.81291180
184Aganglionic megacolon (HP:0002251)1.80500247
185Hypopigmentation of the fundus (HP:0007894)1.78586835
186Progressive macrocephaly (HP:0004481)1.77973199
187Abnormality of the left ventricular outflow tract (HP:0011103)1.77733846
188Subaortic stenosis (HP:0001682)1.77733846
189Heterochromia iridis (HP:0001100)1.77318327
190Degeneration of the lateral corticospinal tracts (HP:0002314)1.75632269
191Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.75632269
192Hypoproteinemia (HP:0003075)1.75145325
193Focal seizures (HP:0007359)1.74977606
194Adrenal hypoplasia (HP:0000835)1.74086437
195Aplasia/Hypoplasia of the tongue (HP:0010295)1.73979996

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.17884643
2TXK4.11716499
3TRIM283.15414045
4WEE13.01676668
5BCR2.91176685
6MAP3K42.82141786
7MARK12.77043265
8MAP3K142.68737271
9MAPK132.64112915
10TYK22.61730300
11WNK32.59463193
12RIPK42.54618997
13PLK22.51290609
14CASK2.35722683
15IKBKE2.34111723
16IRAK42.33967497
17BTK2.33034488
18TEC2.25295125
19TBK12.20396237
20KIT2.19481064
21JAK12.14477412
22BMPR1B2.11717968
23CAMKK22.09002031
24MAP2K72.06639413
25PLK41.99515572
26MAP4K21.98007672
27ITK1.97713489
28JAK31.91929492
29ACVR1B1.91829460
30IKBKB1.87235538
31ZAP701.82553992
32NEK11.81986721
33RPS6KA41.75476074
34TGFBR21.74902053
35PLK31.63227303
36SYK1.62956114
37STK101.60254519
38MKNK21.59278246
39TAOK31.57181436
40PIM11.51100306
41MST41.48711340
42CSF1R1.47149152
43MST1R1.47094172
44TNIK1.46178326
45CCNB11.43683901
46CHUK1.40999759
47FGFR31.39973163
48HCK1.39006267
49SIK31.34887167
50EIF2AK31.31291628
51IRAK31.30393552
52NEK91.27812304
53LCK1.27345559
54SRPK11.26846442
55CSNK1G21.26511946
56YES11.18353165
57LYN1.15940777
58NUAK11.15890656
59MKNK11.13799906
60PINK11.11562457
61UHMK11.10118882
62PNCK1.09292105
63CSNK1G31.06291255
64CSK1.05179286
65STK391.04092276
66MINK11.03695066
67INSRR1.02775024
68PAK31.02591222
69CSNK1A1L1.01395650
70WNK40.96330049
71EIF2AK10.96295068
72CSNK1G10.94211407
73GRK70.93730830
74LATS10.91781529
75BLK0.90848037
76DYRK20.90331947
77TRPM70.89858830
78PTK2B0.89073148
79JAK20.88977995
80STK38L0.88905472
81MUSK0.88288990
82PRKD30.87034280
83FGFR20.86930723
84CDK90.86428238
85BRSK20.85887576
86TNK20.85853572
87DYRK1A0.85231218
88HIPK20.83488421
89EPHB10.82753531
90FES0.81805593
91MARK30.81776116
92CAMK1D0.79952894
93CDK60.76771438
94NTRK20.76685969
95STK40.75850471
96MAP2K30.74732104
97SIK20.74652014
98PRKCG0.74399549
99NTRK30.73657842
100PRKCE0.73619121
101PLK10.72543516
102EPHA30.71969562
103MAP3K120.70502428
104SGK20.70336242
105LRRK20.70312785
106EIF2AK20.70105256
107ERBB30.70010830
108GRK10.69523780
109PIM20.67980449
110CAMK2A0.67867152
111VRK10.67832842
112MAP3K100.66602083
113EPHA40.63620772
114ERN10.63231706
115STK240.62948246
116CDC70.62754686
117MAP2K40.62651738
118CDK30.61755162
119CDK120.60691424
120MAP3K130.60258044
121FRK0.59706960
122RPS6KA60.59548803
123PRKCH0.59080395
124FGFR40.58867648
125FER0.58814949
126SGK30.58637356
127OXSR10.58055737
128ATM0.55490074
129TTK0.54169503
130PKN10.53619174
131FGR0.53567059
132PDK20.51879699
133RPS6KC10.51739308
134RPS6KL10.51739308
135BMX0.51638927
136CLK10.50844735
137ABL10.50735621
138* ATR0.50218533
139PDK10.48691928
140NEK20.47849355
141SCYL20.47750451
142CDK70.47296113
143BMPR20.47112439
144GRK50.47089448
145RPS6KA20.46998324
146DYRK30.46988245
147MAP3K60.46832737
148RPS6KA50.46415828
149PRKCQ0.45713005
150EEF2K0.45581112
151KDR0.45459736
152CDK40.44860809
153BUB10.44755081
154GRK60.44565160
155MAPKAPK50.43799259
156CSNK1D0.43337347
157KSR10.42838797
158TGFBR10.40719373
159NLK0.40600517
160BRD40.39737559
161CAMKK10.38433146
162IGF1R0.38358479
163RPS6KB10.38299895
164ADRBK10.37624670
165ADRBK20.36639052
166STK30.36583657
167MELK0.34656141
168PRKACB0.34261724
169TAF10.32363450
170MAP3K50.31751991
171PRKG10.30956663
172EGFR0.30893328
173PRKACA0.30760762
174ERBB20.30443559
175ZAK0.30097654
176CDK180.30028003

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.21475565
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.57267246
3Primary immunodeficiency_Homo sapiens_hsa053403.13541390
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.78720898
5Basal transcription factors_Homo sapiens_hsa030222.62029156
6Nicotine addiction_Homo sapiens_hsa050332.58718570
7Propanoate metabolism_Homo sapiens_hsa006402.47575259
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.41555078
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.40999882
10Leishmaniasis_Homo sapiens_hsa051402.38704410
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.34979528
12Measles_Homo sapiens_hsa051622.33532122
13Graft-versus-host disease_Homo sapiens_hsa053322.19283820
14Osteoclast differentiation_Homo sapiens_hsa043802.18261043
15Phototransduction_Homo sapiens_hsa047442.16219311
16Intestinal immune network for IgA production_Homo sapiens_hsa046722.14956743
17Hematopoietic cell lineage_Homo sapiens_hsa046402.10709503
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.07420836
19B cell receptor signaling pathway_Homo sapiens_hsa046622.03437631
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.01956632
21Butanoate metabolism_Homo sapiens_hsa006501.98769561
22Allograft rejection_Homo sapiens_hsa053301.98296832
23Antigen processing and presentation_Homo sapiens_hsa046121.96004706
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.93555526
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.88934583
26Steroid biosynthesis_Homo sapiens_hsa001001.83880994
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.83031199
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.79688384
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.76700518
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.74295135
31Viral myocarditis_Homo sapiens_hsa054161.73797562
32Proteasome_Homo sapiens_hsa030501.71170808
33T cell receptor signaling pathway_Homo sapiens_hsa046601.63296703
34Herpes simplex infection_Homo sapiens_hsa051681.58199916
35Collecting duct acid secretion_Homo sapiens_hsa049661.52826170
36Malaria_Homo sapiens_hsa051441.50963390
37GABAergic synapse_Homo sapiens_hsa047271.49911851
38Oocyte meiosis_Homo sapiens_hsa041141.49520202
39Oxidative phosphorylation_Homo sapiens_hsa001901.48856857
40Toxoplasmosis_Homo sapiens_hsa051451.47777897
41Tuberculosis_Homo sapiens_hsa051521.47173290
42Legionellosis_Homo sapiens_hsa051341.45888102
43Chemokine signaling pathway_Homo sapiens_hsa040621.43116841
44Taste transduction_Homo sapiens_hsa047421.40819711
45Apoptosis_Homo sapiens_hsa042101.39928569
46Type I diabetes mellitus_Homo sapiens_hsa049401.39586119
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.39474254
48TNF signaling pathway_Homo sapiens_hsa046681.39239824
49Parkinsons disease_Homo sapiens_hsa050121.38737856
50Influenza A_Homo sapiens_hsa051641.37232139
51Hepatitis B_Homo sapiens_hsa051611.36032046
52Pertussis_Homo sapiens_hsa051331.35259420
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.31999780
54Morphine addiction_Homo sapiens_hsa050321.31028964
55Platelet activation_Homo sapiens_hsa046111.30211101
56Autoimmune thyroid disease_Homo sapiens_hsa053201.28581771
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28243275
58Regulation of autophagy_Homo sapiens_hsa041401.28230187
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27594276
60Dopaminergic synapse_Homo sapiens_hsa047281.22768607
61Transcriptional misregulation in cancer_Homo sapiens_hsa052021.22453259
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.21439651
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21293421
64Shigellosis_Homo sapiens_hsa051311.20578096
65Pancreatic cancer_Homo sapiens_hsa052121.19983447
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17761435
67DNA replication_Homo sapiens_hsa030301.16676898
68Non-homologous end-joining_Homo sapiens_hsa034501.14531959
69Circadian entrainment_Homo sapiens_hsa047131.13316353
70Olfactory transduction_Homo sapiens_hsa047401.12607639
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.11087802
72Circadian rhythm_Homo sapiens_hsa047101.10613365
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08937472
74Salmonella infection_Homo sapiens_hsa051321.08763026
75SNARE interactions in vesicular transport_Homo sapiens_hsa041301.08738008
76Acute myeloid leukemia_Homo sapiens_hsa052211.08463421
77Base excision repair_Homo sapiens_hsa034101.08337055
78Rheumatoid arthritis_Homo sapiens_hsa053231.07837625
79Chronic myeloid leukemia_Homo sapiens_hsa052201.07433514
80Asthma_Homo sapiens_hsa053101.05473490
81Leukocyte transendothelial migration_Homo sapiens_hsa046701.05362626
82Glutamatergic synapse_Homo sapiens_hsa047241.04549088
83Homologous recombination_Homo sapiens_hsa034400.99415951
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99126346
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92685368
86Viral carcinogenesis_Homo sapiens_hsa052030.92542143
87Staphylococcus aureus infection_Homo sapiens_hsa051500.92502030
88Fanconi anemia pathway_Homo sapiens_hsa034600.92043046
89HTLV-I infection_Homo sapiens_hsa051660.91943540
90Huntingtons disease_Homo sapiens_hsa050160.91367309
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.91269081
92Small cell lung cancer_Homo sapiens_hsa052220.91151885
93Nucleotide excision repair_Homo sapiens_hsa034200.91109055
94Phagosome_Homo sapiens_hsa041450.87069210
95RNA transport_Homo sapiens_hsa030130.85297179
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82415774
97Cell cycle_Homo sapiens_hsa041100.82129847
98Hepatitis C_Homo sapiens_hsa051600.81634112
99p53 signaling pathway_Homo sapiens_hsa041150.81604654
100Synaptic vesicle cycle_Homo sapiens_hsa047210.80794355
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79836893
102Epstein-Barr virus infection_Homo sapiens_hsa051690.79691935
103Cocaine addiction_Homo sapiens_hsa050300.78782100
104Fatty acid elongation_Homo sapiens_hsa000620.78511328
105Peroxisome_Homo sapiens_hsa041460.77275223
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76962273
107Amphetamine addiction_Homo sapiens_hsa050310.74445832
108mRNA surveillance pathway_Homo sapiens_hsa030150.73913053
109Vitamin B6 metabolism_Homo sapiens_hsa007500.72958612
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71820197
111Caffeine metabolism_Homo sapiens_hsa002320.71432297
112Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.71304568
113Serotonergic synapse_Homo sapiens_hsa047260.70855583
114Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68887563
115Alzheimers disease_Homo sapiens_hsa050100.68526249
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68178673
117Nitrogen metabolism_Homo sapiens_hsa009100.68118511
118RNA polymerase_Homo sapiens_hsa030200.67255435
119RNA degradation_Homo sapiens_hsa030180.67215557
120Prolactin signaling pathway_Homo sapiens_hsa049170.64383556
121Ether lipid metabolism_Homo sapiens_hsa005650.63436569
122Linoleic acid metabolism_Homo sapiens_hsa005910.63390152
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60441469
124Axon guidance_Homo sapiens_hsa043600.60023958
125beta-Alanine metabolism_Homo sapiens_hsa004100.59261326
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58406861
127Chemical carcinogenesis_Homo sapiens_hsa052040.58357486
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56549073
129Mismatch repair_Homo sapiens_hsa034300.53574007
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53253057
131Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52699405
132FoxO signaling pathway_Homo sapiens_hsa040680.52239540
133Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52093250
134Spliceosome_Homo sapiens_hsa030400.51956442
135MicroRNAs in cancer_Homo sapiens_hsa052060.51770436
136Fatty acid metabolism_Homo sapiens_hsa012120.50751118
137mTOR signaling pathway_Homo sapiens_hsa041500.50440954
138Lysosome_Homo sapiens_hsa041420.50051511
139Endocytosis_Homo sapiens_hsa041440.49964884
140Dorso-ventral axis formation_Homo sapiens_hsa043200.49727259
141Purine metabolism_Homo sapiens_hsa002300.49430579
142Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48424048
143Systemic lupus erythematosus_Homo sapiens_hsa053220.45953461
144Maturity onset diabetes of the young_Homo sapiens_hsa049500.44302276
145Long-term depression_Homo sapiens_hsa047300.43832204
146African trypanosomiasis_Homo sapiens_hsa051430.43722961
147Inositol phosphate metabolism_Homo sapiens_hsa005620.43562920
148Non-small cell lung cancer_Homo sapiens_hsa052230.42353811
149MAPK signaling pathway_Homo sapiens_hsa040100.42316254
150Metabolic pathways_Homo sapiens_hsa011000.41946628
151Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40440110
152Proteoglycans in cancer_Homo sapiens_hsa052050.40328832
153Glycosaminoglycan degradation_Homo sapiens_hsa005310.40126363
154HIF-1 signaling pathway_Homo sapiens_hsa040660.39612025
155Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.39458234
156Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38925759
157Insulin resistance_Homo sapiens_hsa049310.38788061
158Colorectal cancer_Homo sapiens_hsa052100.38773970
159Sphingolipid signaling pathway_Homo sapiens_hsa040710.37939471
160Tryptophan metabolism_Homo sapiens_hsa003800.37330305
161Salivary secretion_Homo sapiens_hsa049700.36589700
162Tyrosine metabolism_Homo sapiens_hsa003500.36543857
163Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36505628
164alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36255427
165Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36245060
166ABC transporters_Homo sapiens_hsa020100.36022942
167Amoebiasis_Homo sapiens_hsa051460.35959465
168Prostate cancer_Homo sapiens_hsa052150.35780309
169Sphingolipid metabolism_Homo sapiens_hsa006000.35488231
170Notch signaling pathway_Homo sapiens_hsa043300.35341748
171Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33220117
172Renin secretion_Homo sapiens_hsa049240.31537325
173VEGF signaling pathway_Homo sapiens_hsa043700.30551321
174Focal adhesion_Homo sapiens_hsa045100.30248952
175Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29925552
176Cholinergic synapse_Homo sapiens_hsa047250.29097424
177Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.28958859
178Fatty acid degradation_Homo sapiens_hsa000710.28271795
179Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27075071
180Primary bile acid biosynthesis_Homo sapiens_hsa001200.26996154
181Selenocompound metabolism_Homo sapiens_hsa004500.26747433

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