CCDC85A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.60755750
2vocalization behavior (GO:0071625)5.46623263
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.36191544
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.32558453
5synaptic vesicle maturation (GO:0016188)5.19460832
6locomotory exploration behavior (GO:0035641)5.14698024
7synaptic vesicle exocytosis (GO:0016079)5.09490679
8regulation of glutamate receptor signaling pathway (GO:1900449)4.99449877
9glutamate secretion (GO:0014047)4.89342216
10neuron cell-cell adhesion (GO:0007158)4.80614196
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.76181646
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.69070605
13protein localization to synapse (GO:0035418)4.66164125
14regulation of synaptic vesicle exocytosis (GO:2000300)4.44969012
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.42989915
16exploration behavior (GO:0035640)4.40789083
17glutamate receptor signaling pathway (GO:0007215)4.29873392
18regulation of neuronal synaptic plasticity (GO:0048168)4.25429157
19synaptic vesicle docking involved in exocytosis (GO:0016081)4.24452365
20neuronal action potential propagation (GO:0019227)4.17901245
21neurotransmitter-gated ion channel clustering (GO:0072578)4.15537302
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.08683657
23dopamine biosynthetic process (GO:0042416)4.08016454
24regulation of synapse structural plasticity (GO:0051823)4.05966434
25synaptic transmission, glutamatergic (GO:0035249)3.99011454
26mating behavior (GO:0007617)3.97525683
27layer formation in cerebral cortex (GO:0021819)3.95881699
28regulation of synaptic vesicle transport (GO:1902803)3.95072843
29neuron recognition (GO:0008038)3.93157702
30neurotransmitter secretion (GO:0007269)3.90613853
31proline transport (GO:0015824)3.89778903
32dendritic spine morphogenesis (GO:0060997)3.81786188
33dopamine transport (GO:0015872)3.80068292
34neuron-neuron synaptic transmission (GO:0007270)3.73831280
35postsynaptic membrane organization (GO:0001941)3.73103646
36positive regulation of synapse maturation (GO:0090129)3.72790838
37long-term memory (GO:0007616)3.72351345
38regulation of excitatory postsynaptic membrane potential (GO:0060079)3.70428545
39prepulse inhibition (GO:0060134)3.65628706
40axonal fasciculation (GO:0007413)3.63620563
41gamma-aminobutyric acid transport (GO:0015812)3.60078216
42positive regulation of membrane potential (GO:0045838)3.59284686
43regulation of postsynaptic membrane potential (GO:0060078)3.56162111
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.55679418
45regulation of dendritic spine morphogenesis (GO:0061001)3.54950455
46presynaptic membrane assembly (GO:0097105)3.49394026
47positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.48731786
48regulation of synaptic plasticity (GO:0048167)3.48275885
49cellular potassium ion homeostasis (GO:0030007)3.47466865
50gamma-aminobutyric acid signaling pathway (GO:0007214)3.47049862
51transmission of nerve impulse (GO:0019226)3.44513179
52long-term synaptic potentiation (GO:0060291)3.42799022
53positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.35036471
54catecholamine transport (GO:0051937)3.34394218
55synaptic vesicle endocytosis (GO:0048488)3.31133701
56regulation of synapse maturation (GO:0090128)3.30640915
57positive regulation of dendritic spine morphogenesis (GO:0061003)3.30082821
58regulation of synaptic transmission, glutamatergic (GO:0051966)3.28320453
59neurotransmitter transport (GO:0006836)3.27077210
60membrane depolarization (GO:0051899)3.25428300
61presynaptic membrane organization (GO:0097090)3.24991309
62positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.23810712
63positive regulation of synaptic transmission, GABAergic (GO:0032230)3.23161835
64positive regulation of dendritic spine development (GO:0060999)3.22229100
65dendrite morphogenesis (GO:0048813)3.21595758
66regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.20166086
67negative regulation of dendrite morphogenesis (GO:0050774)3.16704435
68behavioral fear response (GO:0001662)3.15271151
69behavioral defense response (GO:0002209)3.15271151
70cell communication by electrical coupling (GO:0010644)3.14833287
71negative regulation of synaptic transmission, GABAergic (GO:0032229)3.14529616
72cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.13167064
73membrane depolarization during action potential (GO:0086010)3.12924013
74membrane assembly (GO:0071709)3.12892817
75G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.11871551
76regulation of voltage-gated calcium channel activity (GO:1901385)3.11684800
77regulation of vesicle fusion (GO:0031338)3.10927170
78regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.09360490
79regulation of dendritic spine development (GO:0060998)3.08472861
80regulation of neurotransmitter transport (GO:0051588)3.07256041
81phenol-containing compound catabolic process (GO:0019336)3.05936312
82regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.05866560
83cell migration in hindbrain (GO:0021535)3.04919652
84cerebellar Purkinje cell differentiation (GO:0021702)3.04368064
85regulation of neurotransmitter levels (GO:0001505)3.03055455
86cerebellar granule cell differentiation (GO:0021707)3.02748364
87regulation of neurotransmitter secretion (GO:0046928)3.01468631
88activation of protein kinase A activity (GO:0034199)3.00942996
89sodium ion export (GO:0071436)3.00525871
90response to histamine (GO:0034776)3.00309579
91positive regulation of neurotransmitter transport (GO:0051590)2.99629535
92auditory behavior (GO:0031223)2.99018397
93neuromuscular process controlling balance (GO:0050885)2.98861996
94learning (GO:0007612)2.96580633
95response to cocaine (GO:0042220)2.96257190
96response to auditory stimulus (GO:0010996)2.95210053
97innervation (GO:0060384)2.92174926
98synapse assembly (GO:0007416)2.91815887
99fear response (GO:0042596)2.90246315
100neuromuscular process controlling posture (GO:0050884)2.89133234
101regulation of synaptic transmission (GO:0050804)2.88337509
102dendritic spine organization (GO:0097061)2.87210090
103G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.86785851
104long term synaptic depression (GO:0060292)2.85852160
105synaptic transmission (GO:0007268)2.85777846
106response to gravity (GO:0009629)2.84301125
107positive regulation of synaptic transmission (GO:0050806)2.84072496
108positive regulation of neurotransmitter secretion (GO:0001956)2.82633559
109neuronal ion channel clustering (GO:0045161)2.80004188
110positive regulation of potassium ion transmembrane transport (GO:1901381)2.78923492
111calcium-mediated signaling using intracellular calcium source (GO:0035584)2.78815958
112L-amino acid import (GO:0043092)2.78733674
113regulation of clathrin-mediated endocytosis (GO:2000369)2.77793295
114membrane hyperpolarization (GO:0060081)2.77790021
115amino acid import (GO:0043090)2.75553743
116response to amphetamine (GO:0001975)2.74995707
117negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.74362027
118urinary tract smooth muscle contraction (GO:0014848)2.74348235
119cytoskeletal anchoring at plasma membrane (GO:0007016)2.72302705
120detection of calcium ion (GO:0005513)2.71147303
121regulation of cell communication by electrical coupling (GO:0010649)2.70084199
122regulation of catecholamine metabolic process (GO:0042069)2.69155076
123regulation of dopamine metabolic process (GO:0042053)2.69155076
124dopamine metabolic process (GO:0042417)2.63432492
125regulation of ARF protein signal transduction (GO:0032012)2.61465694
126response to water (GO:0009415)2.60685527
127response to manganese ion (GO:0010042)2.60248805
128potassium ion homeostasis (GO:0055075)2.56407824
129potassium ion import (GO:0010107)2.56102907
130neuromuscular synaptic transmission (GO:0007274)2.54190467

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.10153188
2* GBX2_23144817_ChIP-Seq_PC3_Human3.57204977
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.14306336
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.13118394
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.04009993
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.76373228
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.76373228
8* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.66278889
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.65751725
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64455592
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.58548081
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.55060989
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.48974111
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.47543777
15REST_21632747_ChIP-Seq_MESCs_Mouse2.47469111
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.42946661
17DROSHA_22980978_ChIP-Seq_HELA_Human2.22893082
18* EZH2_27294783_Chip-Seq_ESCs_Mouse2.20553425
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20354161
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.17647747
21RARB_27405468_Chip-Seq_BRAIN_Mouse2.09460912
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03358113
23REST_18959480_ChIP-ChIP_MESCs_Mouse1.94769204
24AR_21572438_ChIP-Seq_LNCaP_Human1.92715672
25IKZF1_21737484_ChIP-ChIP_HCT116_Human1.89612210
26TAF15_26573619_Chip-Seq_HEK293_Human1.88186833
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.87345478
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82717144
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81184272
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.78416281
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76320688
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72199279
33SMAD4_21799915_ChIP-Seq_A2780_Human1.69463791
34PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59885063
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59658186
36* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59507764
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.58858742
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57413260
39P300_19829295_ChIP-Seq_ESCs_Human1.55721996
40ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.52929341
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.49096215
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49005246
43IGF1R_20145208_ChIP-Seq_DFB_Human1.45758348
44* CBX2_27304074_Chip-Seq_ESCs_Mouse1.45384844
45ZNF274_21170338_ChIP-Seq_K562_Hela1.44659570
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44117543
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42335966
48* RING1B_27294783_Chip-Seq_ESCs_Mouse1.37285317
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37171029
50* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36860656
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.34540628
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32700296
53AR_25329375_ChIP-Seq_VCAP_Human1.32511133
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.31712637
55SOX2_21211035_ChIP-Seq_LN229_Gbm1.30829997
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.29380142
57* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28748473
58* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28178535
59* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27460771
60EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23638608
61* STAT3_23295773_ChIP-Seq_U87_Human1.22142476
62RNF2_27304074_Chip-Seq_NSC_Mouse1.22110421
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20664077
64PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.16730032
65AR_19668381_ChIP-Seq_PC3_Human1.15894909
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15091308
67RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14376658
68RING1B_27294783_Chip-Seq_NPCs_Mouse1.13491553
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.11976729
70TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11642151
71KDM2B_26808549_Chip-Seq_K562_Human1.11183971
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11006979
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10376865
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09817386
75* GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09768776
76RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09632124
77FUS_26573619_Chip-Seq_HEK293_Human1.09003674
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08740045
79SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08613347
80WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08302515
81TP53_18474530_ChIP-ChIP_U2OS_Human1.08106022
82* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07779535
83AHR_22903824_ChIP-Seq_MCF-7_Human1.06819645
84RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06499732
85YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06440597
86MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06262348
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05699079
88CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05548350
89TP53_20018659_ChIP-ChIP_R1E_Mouse1.05526776
90TCF4_23295773_ChIP-Seq_U87_Human1.04825317
91RUNX2_22187159_ChIP-Seq_PCA_Human1.03821240
92NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03090185
93NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03090185
94ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02605090
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01042144
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99362654
97TET1_21490601_ChIP-Seq_MESCs_Mouse0.99090170
98VDR_22108803_ChIP-Seq_LS180_Human0.99045853
99PRDM14_20953172_ChIP-Seq_ESCs_Human0.98717172
100OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98338535
101ESR2_21235772_ChIP-Seq_MCF-7_Human0.97919711
102TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97702298
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97702298
104P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95857372
105DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94190554
106BCAT_22108803_ChIP-Seq_LS180_Human0.93646850
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93445719
108SMAD4_21741376_ChIP-Seq_HESCs_Human0.92919949
109TP53_16413492_ChIP-PET_HCT116_Human0.92909271
110JUN_21703547_ChIP-Seq_K562_Human0.92291571
111RXR_22108803_ChIP-Seq_LS180_Human0.92090102
112LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91927530
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90571006
114ZFP281_27345836_Chip-Seq_ESCs_Mouse0.90309523
115CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90127959
116SMAD3_21741376_ChIP-Seq_HESCs_Human0.89618130
117EP300_21415370_ChIP-Seq_HL-1_Mouse0.89410274
118SMAD3_21741376_ChIP-Seq_ESCs_Human0.89129965
119WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88434986
120TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88118513
121KDM2B_26808549_Chip-Seq_REH_Human0.88079066
122EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.87172096
123ER_23166858_ChIP-Seq_MCF-7_Human0.86953908
124NANOG_18555785_Chip-Seq_ESCs_Mouse0.85484359

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.35475286
2MP0003880_abnormal_central_pattern5.03119724
3MP0003635_abnormal_synaptic_transmissio3.99294810
4MP0004270_analgesia3.37156061
5MP0009745_abnormal_behavioral_response3.21317212
6MP0002063_abnormal_learning/memory/cond3.21005703
7MP0009780_abnormal_chondrocyte_physiolo3.01488582
8MP0001968_abnormal_touch/_nociception2.99755904
9MP0002064_seizures2.99375006
10MP0009046_muscle_twitch2.93177981
11MP0002572_abnormal_emotion/affect_behav2.75900294
12MP0005423_abnormal_somatic_nervous2.73473439
13MP0002735_abnormal_chemical_nociception2.54354729
14MP0002734_abnormal_mechanical_nocicepti2.51370533
15MP0001486_abnormal_startle_reflex2.49404299
16MP0002272_abnormal_nervous_system2.45093468
17MP0002736_abnormal_nociception_after2.42513395
18MP0001501_abnormal_sleep_pattern2.30526640
19MP0001440_abnormal_grooming_behavior2.21818012
20MP0002067_abnormal_sensory_capabilities2.00179940
21MP0002822_catalepsy1.98213944
22MP0002733_abnormal_thermal_nociception1.98012989
23MP0006276_abnormal_autonomic_nervous1.93964957
24MP0000778_abnormal_nervous_system1.93255263
25MP0001970_abnormal_pain_threshold1.88434030
26MP0004858_abnormal_nervous_system1.88258246
27MP0003329_amyloid_beta_deposits1.87155708
28MP0002184_abnormal_innervation1.76678907
29MP0002557_abnormal_social/conspecific_i1.76011182
30MP0005386_behavior/neurological_phenoty1.68917780
31MP0004924_abnormal_behavior1.68917780
32MP0008569_lethality_at_weaning1.64717887
33MP0005646_abnormal_pituitary_gland1.61505384
34MP0008438_abnormal_cutaneous_collagen1.60750048
35MP0004130_abnormal_muscle_cell1.59376342
36MP0004811_abnormal_neuron_physiology1.56612605
37MP0000955_abnormal_spinal_cord1.47343540
38MP0005503_abnormal_tendon_morphology1.47316674
39MP0003122_maternal_imprinting1.38547137
40MP0001984_abnormal_olfaction1.37801101
41MP0002909_abnormal_adrenal_gland1.37402858
42MP0002066_abnormal_motor_capabilities/c1.34187749
43MP0002882_abnormal_neuron_morphology1.34136240
44MP0001905_abnormal_dopamine_level1.31391072
45MP0005645_abnormal_hypothalamus_physiol1.30965826
46MP0005167_abnormal_blood-brain_barrier1.30294767
47MP0003879_abnormal_hair_cell1.30245057
48MP0001188_hyperpigmentation1.29957682
49MP0003279_aneurysm1.29662436
50MP0003633_abnormal_nervous_system1.28520727
51MP0003283_abnormal_digestive_organ1.28432913
52MP0010386_abnormal_urinary_bladder1.26240469
53MP0003787_abnormal_imprinting1.22279755
54MP0000749_muscle_degeneration1.20327289
55MP0001958_emphysema1.18974989
56MP0001529_abnormal_vocalization1.15729106
57MP0004215_abnormal_myocardial_fiber1.14843902
58MP0000751_myopathy1.14651142
59MP0001502_abnormal_circadian_rhythm1.14360354
60MP0004142_abnormal_muscle_tone1.11466542
61MP0003631_nervous_system_phenotype1.10707785
62MP0001299_abnormal_eye_distance/1.06584148
63MP0003075_altered_response_to1.06476207
64MP0004885_abnormal_endolymph1.05466556
65MP0002152_abnormal_brain_morphology1.03766727
66MP0003705_abnormal_hypodermis_morpholog1.03300672
67MP0005409_darkened_coat_color1.00925309
68MP0003690_abnormal_glial_cell1.00612701
69MP0002332_abnormal_exercise_endurance0.98641028
70MP0004742_abnormal_vestibular_system0.97845432
71MP0002295_abnormal_pulmonary_circulatio0.97247263
72MP0002837_dystrophic_cardiac_calcinosis0.96567185
73MP0004036_abnormal_muscle_relaxation0.94349745
74MP0004145_abnormal_muscle_electrophysio0.93685092
75MP0004085_abnormal_heartbeat0.93153101
76MP0000534_abnormal_ureter_morphology0.91698875
77MP0004272_abnormal_basement_membrane0.90886107
78MP0004484_altered_response_of0.88423752
79MP0005551_abnormal_eye_electrophysiolog0.88216277
80MP0002229_neurodegeneration0.87871886
81MP0001542_abnormal_bone_strength0.85763022
82MP0003634_abnormal_glial_cell0.84524947
83MP0005171_absent_coat_pigmentation0.82686647
84MP0001963_abnormal_hearing_physiology0.82282642
85MP0002069_abnormal_eating/drinking_beha0.80380388
86MP0005535_abnormal_body_temperature0.77157813
87MP0003632_abnormal_nervous_system0.76562883
88MP0000759_abnormal_skeletal_muscle0.76223831
89MP0008872_abnormal_physiological_respon0.75844343
90MP0002752_abnormal_somatic_nervous0.75741417
91MP0005388_respiratory_system_phenotype0.75518067
92MP0002133_abnormal_respiratory_system0.75518067
93MP0008874_decreased_physiological_sensi0.75297285
94MP0000604_amyloidosis0.74530086
95MP0005275_abnormal_skin_tensile0.74414292
96MP0002108_abnormal_muscle_morphology0.73166120
97MP0005623_abnormal_meninges_morphology0.73103321
98MP0001177_atelectasis0.73031221
99MP0003137_abnormal_impulse_conducting0.73029508
100MP0003045_fibrosis0.72240934
101MP0004084_abnormal_cardiac_muscle0.71955185
102MP0005187_abnormal_penis_morphology0.70252021
103MP0003091_abnormal_cell_migration0.69861347
104MP0002090_abnormal_vision0.69539995
105MP0002876_abnormal_thyroid_physiology0.68485916
106MP0003950_abnormal_plasma_membrane0.68464077
107MP0003123_paternal_imprinting0.68334951
108MP0001986_abnormal_taste_sensitivity0.66737118
109MP0005499_abnormal_olfactory_system0.65886960
110MP0005394_taste/olfaction_phenotype0.65886960
111MP0004087_abnormal_muscle_fiber0.65326857
112MP0000003_abnormal_adipose_tissue0.64985887
113MP0000747_muscle_weakness0.64237110
114MP0005595_abnormal_vascular_smooth0.63802651
115MP0000569_abnormal_digit_pigmentation0.63493669
116MP0006138_congestive_heart_failure0.63181190
117MP0001879_abnormal_lymphatic_vessel0.62561431
118MP0000631_abnormal_neuroendocrine_gland0.62060512
119MP0000013_abnormal_adipose_tissue0.60484886
120MP0000920_abnormal_myelination0.60219182
121MP0006072_abnormal_retinal_apoptosis0.60021087
122MP0002638_abnormal_pupillary_reflex0.58986386
123MP0001485_abnormal_pinna_reflex0.58887751
124MP0005620_abnormal_muscle_contractility0.56571957
125MP0001943_abnormal_respiration0.55421237
126MP0010368_abnormal_lymphatic_system0.54113381
127MP0001664_abnormal_digestion0.52764036

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.65137621
2Myokymia (HP:0002411)6.23439609
3Focal seizures (HP:0007359)5.81882220
4Visual hallucinations (HP:0002367)4.96234528
5Epileptic encephalopathy (HP:0200134)4.84399678
6Atonic seizures (HP:0010819)4.64771191
7Febrile seizures (HP:0002373)4.40805971
8Progressive cerebellar ataxia (HP:0002073)4.24259807
9Absence seizures (HP:0002121)3.99982676
10Dialeptic seizures (HP:0011146)3.87622320
11Broad-based gait (HP:0002136)3.80081475
12Generalized tonic-clonic seizures (HP:0002069)3.75641274
13Hyperventilation (HP:0002883)3.73913666
14Action tremor (HP:0002345)3.38874716
15Supranuclear gaze palsy (HP:0000605)3.37885475
16Dysmetria (HP:0001310)3.16469952
17Mutism (HP:0002300)3.16117770
18Gaze-evoked nystagmus (HP:0000640)3.09088385
19Abnormal eating behavior (HP:0100738)3.08063561
20Amblyopia (HP:0000646)3.01749914
21Dysdiadochokinesis (HP:0002075)3.00973177
22Excessive salivation (HP:0003781)2.97617574
23Drooling (HP:0002307)2.97617574
24Impaired vibration sensation in the lower limbs (HP:0002166)2.97379345
25Ankle clonus (HP:0011448)2.94849833
26Truncal ataxia (HP:0002078)2.92062320
27Abnormality of the lower motor neuron (HP:0002366)2.88709678
28Anxiety (HP:0000739)2.84838369
29Hemiparesis (HP:0001269)2.84191826
30Depression (HP:0000716)2.81665981
31Poor eye contact (HP:0000817)2.81540643
32Progressive inability to walk (HP:0002505)2.78569577
33Protrusio acetabuli (HP:0003179)2.76603632
34Rigidity (HP:0002063)2.76209357
35Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.70975620
36Hypokinesia (HP:0002375)2.70182692
37Fetal akinesia sequence (HP:0001989)2.65208737
38Abnormality of binocular vision (HP:0011514)2.64287911
39Diplopia (HP:0000651)2.64287911
40Diminished movement (HP:0002374)2.63813865
41Vascular tortuosity (HP:0004948)2.55959426
42Morphological abnormality of the pyramidal tract (HP:0002062)2.55511277
43Limb dystonia (HP:0002451)2.50858578
44Abnormal social behavior (HP:0012433)2.50410181
45Impaired social interactions (HP:0000735)2.50410181
46Urinary bladder sphincter dysfunction (HP:0002839)2.49455683
47Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.48174950
48Delayed gross motor development (HP:0002194)2.47109879
49Cerebral inclusion bodies (HP:0100314)2.46863475
50Lower limb muscle weakness (HP:0007340)2.45297140
51Abnormality of salivation (HP:0100755)2.43725960
52Polyphagia (HP:0002591)2.41154906
53Inability to walk (HP:0002540)2.40999718
54Neurofibrillary tangles (HP:0002185)2.40534173
55Postural instability (HP:0002172)2.40509502
56Absent speech (HP:0001344)2.39079787
57Arterial tortuosity (HP:0005116)2.39011670
58Urinary urgency (HP:0000012)2.38502710
59Genetic anticipation (HP:0003743)2.36151205
60Papilledema (HP:0001085)2.35638956
61Scanning speech (HP:0002168)2.34547411
62Epileptiform EEG discharges (HP:0011182)2.33521513
63Incomplete penetrance (HP:0003829)2.31598161
64Termporal pattern (HP:0011008)2.31118513
65Insidious onset (HP:0003587)2.31118513
66Hemiplegia (HP:0002301)2.30629211
67Mask-like facies (HP:0000298)2.30325359
68Lower limb amyotrophy (HP:0007210)2.29141382
69Abnormality of the corticospinal tract (HP:0002492)2.27419781
70Stereotypic behavior (HP:0000733)2.25712297
71Aortic aneurysm (HP:0004942)2.24572821
72EEG with generalized epileptiform discharges (HP:0011198)2.21765046
73Bundle branch block (HP:0011710)2.20553269
74Myotonia (HP:0002486)2.18193267
75Broad metatarsal (HP:0001783)2.18009177
76Impaired smooth pursuit (HP:0007772)2.15794122
77Bradykinesia (HP:0002067)2.14529558
78Pheochromocytoma (HP:0002666)2.13603814
79Obstructive sleep apnea (HP:0002870)2.13022593
80Torticollis (HP:0000473)2.12632721
81Type 1 muscle fiber predominance (HP:0003803)2.10948591
82Hypsarrhythmia (HP:0002521)2.09376777
83Overgrowth (HP:0001548)2.09286548
84Gait ataxia (HP:0002066)2.08647139
85Premature rupture of membranes (HP:0001788)2.08213444
86Blue irides (HP:0000635)2.06925588
87Megalencephaly (HP:0001355)2.06855857
88Hyporeflexia of lower limbs (HP:0002600)2.05830744
89Generalized myoclonic seizures (HP:0002123)2.05063539
90Akinesia (HP:0002304)2.04502072
91Spastic gait (HP:0002064)2.04104840
92Spinal rigidity (HP:0003306)2.02740327
93Status epilepticus (HP:0002133)2.02738622
94Clonus (HP:0002169)2.02006549
95Focal dystonia (HP:0004373)2.01375688
96Ventricular fibrillation (HP:0001663)1.99215399
97Intention tremor (HP:0002080)1.98696708
98Prolonged QT interval (HP:0001657)1.98530603
99Protruding tongue (HP:0010808)1.92978075
100Gait imbalance (HP:0002141)1.90212655
101Rapidly progressive (HP:0003678)1.89818278
102Agitation (HP:0000713)1.89000161
103Abnormal EKG (HP:0003115)1.88967567
104Shallow orbits (HP:0000586)1.85858563
105Abnormality of ocular smooth pursuit (HP:0000617)1.84388969
106Amyotrophic lateral sclerosis (HP:0007354)1.82928600
107Annular pancreas (HP:0001734)1.82788994
108Specific learning disability (HP:0001328)1.82535930
109Impaired vibratory sensation (HP:0002495)1.82359046
110Exotropia (HP:0000577)1.82240449
111Neuronal loss in central nervous system (HP:0002529)1.80923216
112Aplasia/Hypoplasia of the brainstem (HP:0007362)1.80729979
113Hypoplasia of the brainstem (HP:0002365)1.80729979
114Sleep apnea (HP:0010535)1.80650240
115Aplasia involving bones of the upper limbs (HP:0009823)1.80581087
116Aplasia of the phalanges of the hand (HP:0009802)1.80581087
117Aplasia involving bones of the extremities (HP:0009825)1.80581087
118Dyskinesia (HP:0100660)1.79929206
119Neuroendocrine neoplasm (HP:0100634)1.78969220
120Bradycardia (HP:0001662)1.78866618
121Increased variability in muscle fiber diameter (HP:0003557)1.78861753
122Psychosis (HP:0000709)1.77490697
123Absent/shortened dynein arms (HP:0200106)1.76437257
124Dynein arm defect of respiratory motile cilia (HP:0012255)1.76437257
125Hypoventilation (HP:0002791)1.76281718
126Inappropriate behavior (HP:0000719)1.75637647
127Craniofacial dystonia (HP:0012179)1.75424571
128Sudden death (HP:0001699)1.69167121
129Dysmetric saccades (HP:0000641)1.69110019
130Coronal craniosynostosis (HP:0004440)1.67621848
131Spastic tetraparesis (HP:0001285)1.65873900
132Tetraplegia (HP:0002445)1.65069123

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.87329666
2EPHA44.15255589
3MAP3K93.75860953
4MARK13.42015505
5CASK2.90867284
6MAP3K42.59411792
7MINK12.54100484
8TNIK2.40255782
9MAP3K122.31940771
10NTRK22.30416153
11MAP2K72.27741348
12PAK62.02838987
13DAPK21.99030256
14KSR21.98494370
15PRPF4B1.87368441
16MAPKAPK51.74435897
17MAP2K41.69288747
18MAPK131.67751049
19KSR11.67042058
20RIPK11.60053406
21GRK51.51679847
22PLK21.48161176
23PHKG21.47302598
24PHKG11.47302598
25PNCK1.45107665
26CDK51.44749470
27NTRK11.44393682
28DAPK11.40535518
29MAP3K131.39628743
30PRKD31.38887792
31FES1.37588725
32RIPK41.35198112
33PTK2B1.31834132
34ARAF1.26928504
35CAMKK11.24370294
36SIK21.23475592
37PRKCG1.16441118
38LATS21.11600323
39CAMK2A1.07141181
40PAK31.01295125
41SIK30.93608255
42CAMK10.92192193
43MAP3K110.91813283
44MYLK0.91476260
45CAMK2B0.90771702
46STK380.88140925
47UHMK10.87654094
48GRK70.86654883
49CDK190.86382164
50MARK20.86162729
51LIMK10.85995503
52FER0.85206470
53LMTK20.84904509
54DDR20.82766924
55TIE10.82641301
56SGK4940.82071337
57SGK2230.82071337
58CAMKK20.79153096
59NEK90.78777859
60CSNK1G20.75205379
61CDK180.74835535
62CDK140.73859695
63STK110.72820361
64MAP3K20.72255530
65PDGFRA0.72118186
66PTK20.71415450
67SGK20.70897967
68OBSCN0.70865418
69CDK150.70387198
70TYRO30.67897919
71ROCK20.64246092
72ROCK10.63254919
73DYRK1A0.62705703
74PRKCE0.62338885
75PRKCH0.61859814
76MUSK0.60500695
77BCR0.60370615
78SGK10.60205779
79RAF10.60044049
80CDK11A0.59130211
81OXSR10.58807594
82TTN0.57183749
83PAK20.55875758
84RET0.54627322
85AKT30.54581703
86BMPR20.53285190
87ERBB30.52969322
88PKN10.52393373
89CAMK2D0.52227712
90NME10.52059011
91MAPK120.51770321
92ICK0.50997138
93FGR0.50182662
94BRAF0.49698092
95MAP3K10.49559930
96CSNK1G30.49053453
97CAMK1G0.48499444
98MAP2K10.48373684
99EEF2K0.47138178
100TAOK20.46489031
101CAMK2G0.46028618
102SGK30.45921522
103PKN20.45482913
104RPS6KA30.44053894
105FYN0.44011769
106PINK10.43016523
107PRKCZ0.42000203
108PDPK10.41647190
109DAPK30.40455177
110TESK10.39786640
111WNK10.39782875
112MAP3K70.38449542
113MAPK40.38161957
114PRKD20.37802399
115MAPK100.37443490
116PDK10.36772700
117CAMK40.36171786
118TRIB30.34946185
119CDC42BPA0.34650091
120RPS6KA20.33336883
121STK390.31517288
122PRKG10.30925662
123MOS0.30706696
124PRKACA0.30612852
125ADRBK10.30069823

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.85809913
2Synaptic vesicle cycle_Homo sapiens_hsa047213.07644004
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.70348630
4Circadian entrainment_Homo sapiens_hsa047132.64845396
5Long-term potentiation_Homo sapiens_hsa047202.62932918
6Olfactory transduction_Homo sapiens_hsa047402.62563827
7GABAergic synapse_Homo sapiens_hsa047272.60634615
8Glutamatergic synapse_Homo sapiens_hsa047242.52548221
9Morphine addiction_Homo sapiens_hsa050322.42591964
10Amphetamine addiction_Homo sapiens_hsa050312.42474177
11Dopaminergic synapse_Homo sapiens_hsa047282.04348761
12Salivary secretion_Homo sapiens_hsa049702.04153521
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.02772227
14Insulin secretion_Homo sapiens_hsa049111.94042273
15Taste transduction_Homo sapiens_hsa047421.87606381
16Cholinergic synapse_Homo sapiens_hsa047251.81311532
17Gastric acid secretion_Homo sapiens_hsa049711.81060006
18Serotonergic synapse_Homo sapiens_hsa047261.77286637
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74898953
20Renin secretion_Homo sapiens_hsa049241.72870349
21Long-term depression_Homo sapiens_hsa047301.70034158
22Oxytocin signaling pathway_Homo sapiens_hsa049211.66700651
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66539011
24Calcium signaling pathway_Homo sapiens_hsa040201.66329335
25Cocaine addiction_Homo sapiens_hsa050301.55000552
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.51611693
27Collecting duct acid secretion_Homo sapiens_hsa049661.51545018
28GnRH signaling pathway_Homo sapiens_hsa049121.48196913
29Axon guidance_Homo sapiens_hsa043601.41341371
30Gap junction_Homo sapiens_hsa045401.36252647
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32684871
32Cardiac muscle contraction_Homo sapiens_hsa042601.28326866
33cAMP signaling pathway_Homo sapiens_hsa040241.26323643
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23754771
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22634130
36Estrogen signaling pathway_Homo sapiens_hsa049151.14777000
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14438961
38Glioma_Homo sapiens_hsa052141.05923163
39Melanogenesis_Homo sapiens_hsa049161.04863975
40Type II diabetes mellitus_Homo sapiens_hsa049301.03883831
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03195630
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02414700
43ECM-receptor interaction_Homo sapiens_hsa045121.02075883
44ErbB signaling pathway_Homo sapiens_hsa040121.00238087
45Vascular smooth muscle contraction_Homo sapiens_hsa042700.97949978
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95248650
47Dorso-ventral axis formation_Homo sapiens_hsa043200.94897252
48Phospholipase D signaling pathway_Homo sapiens_hsa040720.92917445
49Dilated cardiomyopathy_Homo sapiens_hsa054140.91115898
50Vibrio cholerae infection_Homo sapiens_hsa051100.86230725
51Nitrogen metabolism_Homo sapiens_hsa009100.83332737
52Choline metabolism in cancer_Homo sapiens_hsa052310.82789515
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81838635
54Phototransduction_Homo sapiens_hsa047440.77973036
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77962911
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77325177
57Focal adhesion_Homo sapiens_hsa045100.75629126
58MAPK signaling pathway_Homo sapiens_hsa040100.75188596
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74258331
60Oocyte meiosis_Homo sapiens_hsa041140.73041264
61Pancreatic secretion_Homo sapiens_hsa049720.71800346
62Alzheimers disease_Homo sapiens_hsa050100.70500935
63Ras signaling pathway_Homo sapiens_hsa040140.70369367
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68862639
65Rap1 signaling pathway_Homo sapiens_hsa040150.68196932
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65738543
67Thyroid hormone synthesis_Homo sapiens_hsa049180.65202399
68Oxidative phosphorylation_Homo sapiens_hsa001900.62791387
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62628938
70Glucagon signaling pathway_Homo sapiens_hsa049220.61168541
71Vitamin B6 metabolism_Homo sapiens_hsa007500.60566472
72VEGF signaling pathway_Homo sapiens_hsa043700.59314323
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58301962
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56103725
75Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56039293
76Hippo signaling pathway_Homo sapiens_hsa043900.54196887
77Renal cell carcinoma_Homo sapiens_hsa052110.54107001
78AMPK signaling pathway_Homo sapiens_hsa041520.53259252
79African trypanosomiasis_Homo sapiens_hsa051430.52475481
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.51477872
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51323505
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.50594699
83Prion diseases_Homo sapiens_hsa050200.49841212
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48821053
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45133081
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45019023
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44639046
88Wnt signaling pathway_Homo sapiens_hsa043100.43693073
89Endocytosis_Homo sapiens_hsa041440.43564967
90Prolactin signaling pathway_Homo sapiens_hsa049170.42427505
91Circadian rhythm_Homo sapiens_hsa047100.42419546
92Parkinsons disease_Homo sapiens_hsa050120.42283610
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42202822
94Inositol phosphate metabolism_Homo sapiens_hsa005620.41912275
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41700638
96Bile secretion_Homo sapiens_hsa049760.41048439
97Proteoglycans in cancer_Homo sapiens_hsa052050.41002471
98Alcoholism_Homo sapiens_hsa050340.39722663
99Insulin signaling pathway_Homo sapiens_hsa049100.39081184
100Amoebiasis_Homo sapiens_hsa051460.38119684
101Fatty acid biosynthesis_Homo sapiens_hsa000610.36797076
102Ovarian steroidogenesis_Homo sapiens_hsa049130.35451388
103Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35325451
104Endometrial cancer_Homo sapiens_hsa052130.34449944
105Huntingtons disease_Homo sapiens_hsa050160.34118650
106Melanoma_Homo sapiens_hsa052180.34072882
107Rheumatoid arthritis_Homo sapiens_hsa053230.33752291
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33204062
109mTOR signaling pathway_Homo sapiens_hsa041500.27515924
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27508448
111Type I diabetes mellitus_Homo sapiens_hsa049400.27229144
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26534995
113Tight junction_Homo sapiens_hsa045300.25370035

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