CCDC86

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.93060304
2mitotic chromosome condensation (GO:0007076)4.38887087
3protein maturation by protein folding (GO:0022417)4.19322656
4establishment of integrated proviral latency (GO:0075713)4.14990650
5regulation of translational fidelity (GO:0006450)4.08226712
6negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.02159509
7maturation of SSU-rRNA (GO:0030490)4.00626715
8ribosomal small subunit assembly (GO:0000028)3.98084581
9DNA strand elongation involved in DNA replication (GO:0006271)3.91573573
10proline biosynthetic process (GO:0006561)3.90796495
11proteasome assembly (GO:0043248)3.86551791
12regulation of translational termination (GO:0006449)3.85839371
13nucleobase-containing small molecule interconversion (GO:0015949)3.84148511
14DNA replication checkpoint (GO:0000076)3.76329463
15mitotic sister chromatid segregation (GO:0000070)3.76105012
16DNA strand elongation (GO:0022616)3.73568142
17regulation of mitochondrial translation (GO:0070129)3.73155534
18formation of translation preinitiation complex (GO:0001731)3.71817756
19telomere maintenance via semi-conservative replication (GO:0032201)3.71577513
20ribosome biogenesis (GO:0042254)3.68729960
21DNA replication initiation (GO:0006270)3.66993083
22heterochromatin organization (GO:0070828)3.65950306
23ribosomal large subunit biogenesis (GO:0042273)3.57730183
24ribonucleoprotein complex biogenesis (GO:0022613)3.55789332
25nucleobase biosynthetic process (GO:0046112)3.54031268
26peptidyl-arginine omega-N-methylation (GO:0035247)3.47018327
27mitotic metaphase plate congression (GO:0007080)3.45312161
28ribosome assembly (GO:0042255)3.43727089
29transcription from mitochondrial promoter (GO:0006390)3.43378296
30rRNA transcription (GO:0009303)3.42874309
31protein complex localization (GO:0031503)3.41662241
32purine nucleobase biosynthetic process (GO:0009113)3.41547624
33viral transcription (GO:0019083)3.40369706
34nuclear pore complex assembly (GO:0051292)3.38131037
35negative regulation of mRNA processing (GO:0050686)3.37570855
36spliceosomal tri-snRNP complex assembly (GO:0000244)3.35930180
37ribosomal small subunit biogenesis (GO:0042274)3.35656312
38establishment of viral latency (GO:0019043)3.35486843
39regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.34184643
40telomere maintenance via recombination (GO:0000722)3.33866014
41translational termination (GO:0006415)3.33493559
42COPI coating of Golgi vesicle (GO:0048205)3.31893649
43Golgi transport vesicle coating (GO:0048200)3.31893649
44rRNA processing (GO:0006364)3.26008243
45sister chromatid segregation (GO:0000819)3.22755303
46pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.21939277
47IMP biosynthetic process (GO:0006188)3.20813940
48spliceosomal snRNP assembly (GO:0000387)3.18550654
49negative regulation of RNA splicing (GO:0033119)3.17159593
50rRNA metabolic process (GO:0016072)3.15223462
51translational initiation (GO:0006413)3.14841680
52negative regulation of mRNA metabolic process (GO:1903312)3.12463137
53DNA unwinding involved in DNA replication (GO:0006268)3.12067574
54regulation of mammary gland epithelial cell proliferation (GO:0033599)3.09232188
55pseudouridine synthesis (GO:0001522)3.07636765
56pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.07394918
57mitotic nuclear envelope reassembly (GO:0007084)3.07120197
58nuclear envelope reassembly (GO:0031468)3.07120197
59translational elongation (GO:0006414)3.06580750
60protein localization to kinetochore (GO:0034501)3.06442803
61mitotic recombination (GO:0006312)3.05243706
62telomere maintenance via telomere lengthening (GO:0010833)3.05158251
63termination of RNA polymerase III transcription (GO:0006386)3.04211609
64transcription elongation from RNA polymerase III promoter (GO:0006385)3.04211609
65mitotic nuclear envelope disassembly (GO:0007077)3.01569434
66rRNA modification (GO:0000154)3.01455754
67nuclear pore organization (GO:0006999)3.01237111
68pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.00647259
69histone arginine methylation (GO:0034969)2.98932179
70tRNA methylation (GO:0030488)2.98534639
71cellular protein complex localization (GO:0034629)2.97641298
72pteridine-containing compound biosynthetic process (GO:0042559)2.97425147
73chromatin remodeling at centromere (GO:0031055)2.95613346
74CENP-A containing nucleosome assembly (GO:0034080)2.95123062
75SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.93686284
76tRNA aminoacylation for protein translation (GO:0006418)2.92424263
77kinetochore assembly (GO:0051382)2.92093943
78negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.91764656
79folic acid-containing compound biosynthetic process (GO:0009396)2.91757949
80mitochondrial RNA metabolic process (GO:0000959)2.88057978
81metaphase plate congression (GO:0051310)2.87295826
82anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.87187586
83chromosome condensation (GO:0030261)2.86313309
84positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.86275003
85regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.85504581
86kinetochore organization (GO:0051383)2.84815960
87amino acid activation (GO:0043038)2.84355198
88tRNA aminoacylation (GO:0043039)2.84355198
89protein targeting to mitochondrion (GO:0006626)2.84123683
90protein targeting to ER (GO:0045047)2.82913351
91antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.82860752
92antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.82814371
93nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.82504585
94cotranslational protein targeting to membrane (GO:0006613)2.82322692
95transcription-coupled nucleotide-excision repair (GO:0006283)2.80974888
96IMP metabolic process (GO:0046040)2.77868980
97nucleotide-excision repair, DNA gap filling (GO:0006297)2.77006694
98peptidyl-arginine methylation (GO:0018216)2.76748788
99peptidyl-arginine N-methylation (GO:0035246)2.76748788
100pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.76506952
101transcription from RNA polymerase I promoter (GO:0006360)2.76446274
102folic acid metabolic process (GO:0046655)2.75671734
103DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.72390750
104UTP biosynthetic process (GO:0006228)2.72382948
105mRNA splicing, via spliceosome (GO:0000398)2.71628549
106RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.71628549
107nuclear envelope disassembly (GO:0051081)2.71592230
108membrane disassembly (GO:0030397)2.71592230
109positive regulation of chromosome segregation (GO:0051984)2.71276053
110regulation of double-strand break repair via homologous recombination (GO:0010569)2.70128565
111regulation of translational elongation (GO:0006448)2.69873133
112protein localization to chromosome, centromeric region (GO:0071459)2.69859952
113signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.69469037
114signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.69469037
115signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.69469037
116regulation of nuclear cell cycle DNA replication (GO:0033262)2.69015550
117signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.68533042
118intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.68533042
119translation (GO:0006412)2.68225734
120transcription elongation from RNA polymerase I promoter (GO:0006362)2.67721359
121termination of RNA polymerase I transcription (GO:0006363)2.66626587
122viral life cycle (GO:0019058)2.65952097
123establishment of chromosome localization (GO:0051303)2.65849167
124G1/S transition of mitotic cell cycle (GO:0000082)2.65797889
125cell cycle G1/S phase transition (GO:0044843)2.65797889
126signal transduction involved in DNA damage checkpoint (GO:0072422)2.65748910
127signal transduction involved in DNA integrity checkpoint (GO:0072401)2.65748910
128establishment of protein localization to endoplasmic reticulum (GO:0072599)2.64988011
129negative regulation of ligase activity (GO:0051352)2.64241654
130negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.64241654
131protein localization to endoplasmic reticulum (GO:0070972)2.63301459
132immunoglobulin mediated immune response (GO:0016064)2.62910355
133DNA replication-independent nucleosome organization (GO:0034724)2.62371718
134DNA replication-independent nucleosome assembly (GO:0006336)2.62371718
135deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.61914228
136signal transduction involved in cell cycle checkpoint (GO:0072395)2.61460512
137cellular protein complex disassembly (GO:0043624)2.59426308
1387-methylguanosine mRNA capping (GO:0006370)2.57976409
139regulation of spindle organization (GO:0090224)2.57976393
140maturation of 5.8S rRNA (GO:0000460)2.57460698
141cellular component biogenesis (GO:0044085)2.57164250
142exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.56537256
143DNA-dependent DNA replication (GO:0006261)2.55887708
1447-methylguanosine RNA capping (GO:0009452)2.54985132
145RNA capping (GO:0036260)2.54985132
146B cell mediated immunity (GO:0019724)2.52548559
147positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.50521842
148viral mRNA export from host cell nucleus (GO:0046784)2.49724362
149DNA replication-dependent nucleosome assembly (GO:0006335)2.49121285

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.38407982
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.11441492
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.50172988
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.11870131
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.98399704
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.94627121
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.93372445
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.91513002
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.88763263
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.79862330
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.79698269
12* ETS1_20019798_ChIP-Seq_JURKAT_Human2.76529926
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.73948814
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.65975932
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.54089612
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.38722654
17* VDR_23849224_ChIP-Seq_CD4+_Human2.18900359
18XRN2_22483619_ChIP-Seq_HELA_Human2.15370863
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.14773325
20ZNF263_19887448_ChIP-Seq_K562_Human2.10598554
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.09904811
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.05709853
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.05412432
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.03910793
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.01608084
26DCP1A_22483619_ChIP-Seq_HELA_Human1.99110169
27E2F1_18555785_ChIP-Seq_MESCs_Mouse1.93278624
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.89293392
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.85355118
30IRF8_21731497_ChIP-ChIP_J774_Mouse1.85172046
31FOXP3_21729870_ChIP-Seq_TREG_Human1.83708635
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.83157404
33GABP_19822575_ChIP-Seq_HepG2_Human1.81437744
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.81279094
35* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.73432918
36TTF2_22483619_ChIP-Seq_HELA_Human1.73397404
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.69653749
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.68270059
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66145260
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.65728067
41ELK1_19687146_ChIP-ChIP_HELA_Human1.65555981
42* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.65040502
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.64172938
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.63750011
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.63169353
46* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.61881584
47TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60701034
48AR_21909140_ChIP-Seq_LNCAP_Human1.56870495
49PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56424668
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55154116
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54654040
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.54426620
53* SRF_21415370_ChIP-Seq_HL-1_Mouse1.51034851
54E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.50573718
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48727652
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.45112629
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44673746
58* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44643010
59SPI1_23547873_ChIP-Seq_NB4_Human1.41998385
60IRF8_22096565_ChIP-ChIP_GC-B_Human1.41995499
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41781454
62BP1_19119308_ChIP-ChIP_Hs578T_Human1.40698643
63* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.38080971
64MYC_22102868_ChIP-Seq_BL_Human1.33923892
65* CIITA_25753668_ChIP-Seq_RAJI_Human1.30016481
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29260557
67* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27520137
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.27166653
69TFEB_21752829_ChIP-Seq_HELA_Human1.26489345
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25858459
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25313995
72KDM5A_27292631_Chip-Seq_BREAST_Human1.23660508
73* ELK3_25401928_ChIP-Seq_HUVEC_Human1.22923106
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20036248
75YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19040665
76ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17787003
77SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.16815605
78* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15662893
79SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15337481
80* TET1_21451524_ChIP-Seq_MESCs_Mouse1.14082954
81RACK7_27058665_Chip-Seq_MCF-7_Human1.12852726
82MYB_21317192_ChIP-Seq_ERMYB_Mouse1.11623017
83ELK1_22589737_ChIP-Seq_MCF10A_Human1.10355016
84VDR_21846776_ChIP-Seq_THP-1_Human1.09753106
85LXR_22292898_ChIP-Seq_THP-1_Human1.07794867
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07264100
87TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06944189
88KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.06156854
89TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05823542
90STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05339038
91CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05337365
92MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05053187
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03996809
94TBX5_21415370_ChIP-Seq_HL-1_Mouse1.03918241
95* ATF3_27146783_Chip-Seq_COLON_Human1.02609250
96KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01627001
97CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01569360
98POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01141311
99E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00957213
100GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00857797
101HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98544247
102SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.98257760
103DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97900444
104CTCF_18555785_ChIP-Seq_MESCs_Mouse0.97869935
105* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97494749
106NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.96827958
107* CHD1_26751641_Chip-Seq_LNCaP_Human0.96356446
108ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95427017
109* FOXP1_21924763_ChIP-Seq_HESCs_Human0.95304083
110PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93531595
111TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.92645113
112* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92504721
113MYC_18940864_ChIP-ChIP_HL60_Human0.91601307
114TP63_17297297_ChIP-ChIP_HaCaT_Human0.91380538
115BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89769671
116PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.89452625
117KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89069824
118KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87952520
119SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.87877980
120CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87075684
121RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.84105859
122PADI4_21655091_ChIP-ChIP_MCF-7_Human0.83669590
123RUNX1_22412390_ChIP-Seq_EML_Mouse0.79487585
124NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.79385584
125BRD4_27068464_Chip-Seq_AML-cells_Mouse0.79004325
126TCF3_18692474_ChIP-Seq_MEFs_Mouse0.78872066
127MYB_26560356_Chip-Seq_TH1_Human0.77064698

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.82696320
2MP0003111_abnormal_nucleus_morphology3.53932210
3MP0010094_abnormal_chromosome_stability3.33839949
4MP0004957_abnormal_blastocyst_morpholog3.18935497
5MP0008057_abnormal_DNA_replication3.13010800
6MP0003077_abnormal_cell_cycle3.09997388
7MP0008058_abnormal_DNA_repair2.87433940
8MP0005451_abnormal_body_composition2.74736122
9MP0002877_abnormal_melanocyte_morpholog2.67874895
10MP0008007_abnormal_cellular_replicative2.50970563
11MP0000678_abnormal_parathyroid_gland2.47664317
12MP0001835_abnormal_antigen_presentation2.43533563
13MP0002396_abnormal_hematopoietic_system2.23813897
14MP0009333_abnormal_splenocyte_physiolog2.12692426
15MP0003436_decreased_susceptibility_to2.10342567
16MP0008932_abnormal_embryonic_tissue2.08914648
17MP0004233_abnormal_muscle_weight2.08393183
18MP0009785_altered_susceptibility_to2.05525723
19MP0003705_abnormal_hypodermis_morpholog1.96638960
20MP0000490_abnormal_crypts_of1.85631478
21MP0002148_abnormal_hypersensitivity_rea1.84010405
22MP0003786_premature_aging1.73199040
23MP0001853_heart_inflammation1.72837693
24MP0010352_gastrointestinal_tract_polyps1.67650671
25MP0005501_abnormal_skin_physiology1.67627968
26MP0002796_impaired_skin_barrier1.67602398
27MP0004185_abnormal_adipocyte_glucose1.67417887
28MP0005000_abnormal_immune_tolerance1.62409948
29MP0000858_altered_metastatic_potential1.61422461
30MP0010307_abnormal_tumor_latency1.61026484
31MP0000350_abnormal_cell_proliferation1.60409399
32MP0005025_abnormal_response_to1.59694278
33MP0002452_abnormal_antigen_presenting1.58035138
34MP0003315_abnormal_perineum_morphology1.56905514
35MP0001730_embryonic_growth_arrest1.54476690
36MP0005623_abnormal_meninges_morphology1.53858917
37MP0005671_abnormal_response_to1.51829742
38MP0009672_abnormal_birth_weight1.49858616
39MP0002419_abnormal_innate_immunity1.49494433
40MP0002723_abnormal_immune_serum1.49160208
41MP0001800_abnormal_humoral_immune1.49129933
42MP0001545_abnormal_hematopoietic_system1.46253732
43MP0005397_hematopoietic_system_phenotyp1.46253732
44MP0000537_abnormal_urethra_morphology1.45542401
45MP0000685_abnormal_immune_system1.45235182
46MP0006082_CNS_inflammation1.44139192
47MP0010234_abnormal_vibrissa_follicle1.43904862
48MP0003718_maternal_effect1.43831373
49MP0002398_abnormal_bone_marrow1.43525321
50MP0001661_extended_life_span1.43008136
51MP0006036_abnormal_mitochondrial_physio1.42744060
52MP0003763_abnormal_thymus_physiology1.40666278
53MP0003186_abnormal_redox_activity1.40093430
54MP0002405_respiratory_system_inflammati1.38436674
55MP0000313_abnormal_cell_death1.36581600
56MP0003941_abnormal_skin_development1.35730289
57MP0003566_abnormal_cell_adhesion1.35294883
58* MP0001819_abnormal_immune_cell1.35008069
59MP0006035_abnormal_mitochondrial_morpho1.34798109
60MP0002019_abnormal_tumor_incidence1.34267145
61* MP0002420_abnormal_adaptive_immunity1.33565268
62MP0000689_abnormal_spleen_morphology1.31201610
63MP0002722_abnormal_immune_system1.30021145
64MP0003724_increased_susceptibility_to1.29138706
65MP0002132_abnormal_respiratory_system1.27490999
66MP0001790_abnormal_immune_system1.27297005
67MP0005387_immune_system_phenotype1.27297005
68MP0004808_abnormal_hematopoietic_stem1.23865117
69* MP0000716_abnormal_immune_system1.23645381
70MP0003448_altered_tumor_morphology1.22319500
71* MP0002429_abnormal_blood_cell1.20550101
72MP0001672_abnormal_embryogenesis/_devel1.19400983
73MP0005380_embryogenesis_phenotype1.19400983
74MP0001849_ear_inflammation1.19171038
75MP0005058_abnormal_lysosome_morphology1.17571557
76MP0009697_abnormal_copulation1.16940821
77MP0008877_abnormal_DNA_methylation1.15199369
78MP0000703_abnormal_thymus_morphology1.11779330
79MP0009053_abnormal_anal_canal1.10891024
80MP0000003_abnormal_adipose_tissue1.09705323
81MP0002163_abnormal_gland_morphology1.09619279
82MP0001346_abnormal_lacrimal_gland1.08309099
83MP0002277_abnormal_respiratory_mucosa1.06585751
84MP0003984_embryonic_growth_retardation1.06305880
85MP0003123_paternal_imprinting1.06201599
86MP0001697_abnormal_embryo_size1.05328753
87* MP0002080_prenatal_lethality1.04714944
88MP0002060_abnormal_skin_morphology1.04710685
89MP0002088_abnormal_embryonic_growth/wei1.02537120
90MP0005330_cardiomyopathy0.98728802
91MP0010155_abnormal_intestine_physiology0.98532285
92MP0004197_abnormal_fetal_growth/weight/0.97600531
93MP0001845_abnormal_inflammatory_respons0.96145500
94MP0001533_abnormal_skeleton_physiology0.95694231
95MP0004272_abnormal_basement_membrane0.94802880
96MP0001881_abnormal_mammary_gland0.89993836
97MP0005174_abnormal_tail_pigmentation0.89327591
98MP0001293_anophthalmia0.88777694
99MP0002086_abnormal_extraembryonic_tissu0.88138875
100MP0005076_abnormal_cell_differentiation0.88088388
101MP0002085_abnormal_embryonic_tissue0.87801954
102MP0002210_abnormal_sex_determination0.87387051
103MP0002089_abnormal_postnatal_growth/wei0.86323459
104MP0004858_abnormal_nervous_system0.86238410
105MP0002160_abnormal_reproductive_system0.85724267
106MP0005464_abnormal_platelet_physiology0.85541212
107MP0006292_abnormal_olfactory_placode0.84354101
108MP0002249_abnormal_larynx_morphology0.84169637
109MP0008260_abnormal_autophagy0.83947008
110MP0008469_abnormal_protein_level0.83597323
111MP0000762_abnormal_tongue_morphology0.83050365
112MP0009278_abnormal_bone_marrow0.82590721
113MP0005257_abnormal_intraocular_pressure0.82128742
114MP0003453_abnormal_keratinocyte_physiol0.82056727
115MP0000733_abnormal_muscle_development0.81980625
116MP0002006_tumorigenesis0.81628129
117MP0003942_abnormal_urinary_system0.80901154
118MP0005023_abnormal_wound_healing0.80363310
119MP0002933_joint_inflammation0.79046051
120MP0003567_abnormal_fetal_cardiomyocyte0.78358851
121MP0001727_abnormal_embryo_implantation0.78072747
122MP0003303_peritoneal_inflammation0.77195027
123MP0000343_altered_response_to0.77150426
124MP0001216_abnormal_epidermal_layer0.76771334
125MP0001119_abnormal_female_reproductive0.75627454
126MP0004947_skin_inflammation0.73494815
127MP0005390_skeleton_phenotype0.73019709
128MP0000750_abnormal_muscle_regeneration0.72883006
129MP0009764_decreased_sensitivity_to0.72100928
130MP0002697_abnormal_eye_size0.72053576
131MP0005621_abnormal_cell_physiology0.71957806
132MP0002111_abnormal_tail_morphology0.71707838
133MP0001145_abnormal_male_reproductive0.71561363
134MP0000627_abnormal_mammary_gland0.71233997
135MP0002269_muscular_atrophy0.70999656
136MP0005375_adipose_tissue_phenotype0.70157915
137MP0003828_pulmonary_edema0.70106346
138MP0009379_abnormal_foot_pigmentation0.68588999
139MP0005666_abnormal_adipose_tissue0.67836306
140MP0005379_endocrine/exocrine_gland_phen0.67585269
141MP0002084_abnormal_developmental_patter0.67377480
142MP0003385_abnormal_body_wall0.67373903
143MP0000358_abnormal_cell_content/0.66776206
144MP0010030_abnormal_orbit_morphology0.66509183
145MP0005384_cellular_phenotype0.65035664
146MP0003806_abnormal_nucleotide_metabolis0.64711458
147MP0000467_abnormal_esophagus_morphology0.64198379
148MP0001915_intracranial_hemorrhage0.63713122
149MP0000759_abnormal_skeletal_muscle0.63402051
150MP0008438_abnormal_cutaneous_collagen0.63288917
151MP0005075_abnormal_melanosome_morpholog0.62870993
152MP0000747_muscle_weakness0.62259377
153MP0005670_abnormal_white_adipose0.61819834
154MP0009250_abnormal_appendicular_skeleto0.60931028

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.35921172
2Progressive muscle weakness (HP:0003323)4.34860364
3Reticulocytopenia (HP:0001896)3.97910146
4Chromsome breakage (HP:0040012)3.69416135
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.68801112
6Microvesicular hepatic steatosis (HP:0001414)3.68364354
7Abnormality of cells of the erythroid lineage (HP:0012130)3.63528828
8Abnormal number of erythroid precursors (HP:0012131)3.53519063
9Ragged-red muscle fibers (HP:0003200)3.37510914
10Breast hypoplasia (HP:0003187)3.32419439
11Rough bone trabeculation (HP:0100670)3.21670510
12Recurrent abscess formation (HP:0002722)3.19171568
13Oral leukoplakia (HP:0002745)3.09055057
14Eczematoid dermatitis (HP:0000976)3.07682339
15Abnormality of glycolysis (HP:0004366)2.99773725
16Aplastic anemia (HP:0001915)2.99054788
17Degeneration of anterior horn cells (HP:0002398)2.95210731
18Abnormality of the anterior horn cell (HP:0006802)2.95210731
19Poor head control (HP:0002421)2.93263950
20Pallor (HP:0000980)2.92650380
21Testicular atrophy (HP:0000029)2.86524787
22Recurrent bacterial skin infections (HP:0005406)2.84965028
23Premature graying of hair (HP:0002216)2.73046497
24Trismus (HP:0000211)2.72630967
25Agnosia (HP:0010524)2.70123007
26Meckel diverticulum (HP:0002245)2.69608615
27Patellar aplasia (HP:0006443)2.63987633
28Absent thumb (HP:0009777)2.63467654
29Abnormality of the umbilical cord (HP:0010881)2.62591982
30Macrocytic anemia (HP:0001972)2.62274994
31Increased serum pyruvate (HP:0003542)2.60962854
32Hyperacusis (HP:0010780)2.60647943
33Achilles tendon contracture (HP:0001771)2.60422218
34Abnormality of the preputium (HP:0100587)2.58903366
35Carpal bone hypoplasia (HP:0001498)2.58030910
36Abnormality of the ileum (HP:0001549)2.55548912
37Mediastinal lymphadenopathy (HP:0100721)2.53334848
38Cleft eyelid (HP:0000625)2.52588187
39Bone marrow hypocellularity (HP:0005528)2.51658283
40Abnormal trabecular bone morphology (HP:0100671)2.50861226
41Cerebral hypomyelination (HP:0006808)2.48733098
42Aplasia/Hypoplasia of the patella (HP:0006498)2.48629101
43Elevated erythrocyte sedimentation rate (HP:0003565)2.44836224
44Abnormality of chromosome stability (HP:0003220)2.42411803
45Multiple enchondromatosis (HP:0005701)2.38203185
46Aplasia/Hypoplasia of the uvula (HP:0010293)2.36207234
47Glossoptosis (HP:0000162)2.35268714
48Premature rupture of membranes (HP:0001788)2.34562321
49Obstructive lung disease (HP:0006536)2.34535363
50Chronic obstructive pulmonary disease (HP:0006510)2.34535363
51Squamous cell carcinoma (HP:0002860)2.32600525
52Thrombocytosis (HP:0001894)2.32278458
53Abnormal gallbladder physiology (HP:0012438)2.32239775
54Cholecystitis (HP:0001082)2.32239775
55Septate vagina (HP:0001153)2.32151346
56Unilateral renal agenesis (HP:0000122)2.30983730
57Aplasia/Hypoplasia of the sacrum (HP:0008517)2.30485758
5811 pairs of ribs (HP:0000878)2.29282427
59Abnormality of the Achilles tendon (HP:0005109)2.28329340
60Pulmonary fibrosis (HP:0002206)2.27501424
61Insomnia (HP:0100785)2.24350079
62Progressive external ophthalmoplegia (HP:0000590)2.23792300
63Type I transferrin isoform profile (HP:0003642)2.23588152
64Myelodysplasia (HP:0002863)2.22263374
65Abnormality of the fetal cardiovascular system (HP:0010948)2.21849221
66Abnormal umbilical cord blood vessels (HP:0011403)2.21849221
67Single umbilical artery (HP:0001195)2.21849221
68Decreased activity of mitochondrial respiratory chain (HP:0008972)2.20011688
69Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.20011688
70Microretrognathia (HP:0000308)2.19701993
71Abnormality of macrophages (HP:0004311)2.19421777
72Deviation of the thumb (HP:0009603)2.19378603
73Proximal placement of thumb (HP:0009623)2.17923168
74Selective tooth agenesis (HP:0001592)2.17868041
75Truncus arteriosus (HP:0001660)2.17446821
76Tracheoesophageal fistula (HP:0002575)2.15913834
77Secondary amenorrhea (HP:0000869)2.15469704
78Lymphoma (HP:0002665)2.13292880
79Absent radius (HP:0003974)2.13064726
80Basal ganglia calcification (HP:0002135)2.12757101
81Pancytopenia (HP:0001876)2.10506463
82Reduced antithrombin III activity (HP:0001976)2.09647169
83Abnormality of the distal phalanges of the toes (HP:0010182)2.08303891
84Cellular immunodeficiency (HP:0005374)2.06619084
85Broad distal phalanx of finger (HP:0009836)2.06336294
86Irregular epiphyses (HP:0010582)2.05014142
87Ectopic kidney (HP:0000086)2.04401293
88Stenosis of the external auditory canal (HP:0000402)2.04292249
89Premature ovarian failure (HP:0008209)2.03964458
90Petechiae (HP:0000967)2.03403092
91Generalized amyotrophy (HP:0003700)2.02167726
92Stomatitis (HP:0010280)2.02040670
93Abnormal mitochondria in muscle tissue (HP:0008316)2.01510263
94Triphalangeal thumb (HP:0001199)1.99945679
95Increased nuchal translucency (HP:0010880)1.99429894
96Autoimmune thrombocytopenia (HP:0001973)1.98929745
97Hypokinesia (HP:0002375)1.97857241
98Long palpebral fissure (HP:0000637)1.97732813
99Nausea (HP:0002018)1.97083563
100Recurrent gram-negative bacterial infections (HP:0005420)1.97069094
101Sparse lateral eyebrow (HP:0005338)1.95626915
102Duplicated collecting system (HP:0000081)1.94969446
103Vertebral compression fractures (HP:0002953)1.94861157
104Abnormalities of placenta or umbilical cord (HP:0001194)1.94666775
105Hypergonadotropic hypogonadism (HP:0000815)1.94263764
106Increased IgM level (HP:0003496)1.93737449
107Impulsivity (HP:0100710)1.92954421
108Increased serum lactate (HP:0002151)1.91688318
109Aplasia involving forearm bones (HP:0009822)1.91609306
110Absent forearm bone (HP:0003953)1.91609306
111Centrally nucleated skeletal muscle fibers (HP:0003687)1.90447099
112Breech presentation (HP:0001623)1.90237404
113Duodenal stenosis (HP:0100867)1.89501787
114Small intestinal stenosis (HP:0012848)1.89501787
115Abnormal number of incisors (HP:0011064)1.87942307
116Hypoparathyroidism (HP:0000829)1.87080668
117Recurrent viral infections (HP:0004429)1.86697471
118Nonimmune hydrops fetalis (HP:0001790)1.86599244
119Granulocytopenia (HP:0001913)1.85797617
120Recurrent fungal infections (HP:0002841)1.85779290
121Urethral obstruction (HP:0000796)1.85361272
122Neoplasm of the pancreas (HP:0002894)1.84172460
123Gout (HP:0001997)1.84086002
124Aseptic necrosis (HP:0010885)1.83566593
125Horseshoe kidney (HP:0000085)1.83085963
126Atresia of the external auditory canal (HP:0000413)1.82901151
127Leukopenia (HP:0001882)1.82551064
128Ulnar bowing (HP:0003031)1.82549908
129Clubbing of toes (HP:0100760)1.82264119
130Exercise intolerance (HP:0003546)1.81935780
131Preauricular skin tag (HP:0000384)1.81898288
132Pustule (HP:0200039)1.81433090
133Abnormality of reticulocytes (HP:0004312)1.81112207
134Tongue fasciculations (HP:0001308)1.80412272
135Facial cleft (HP:0002006)1.79700286
136Reduced subcutaneous adipose tissue (HP:0003758)1.79676689
137Overlapping toe (HP:0001845)1.79345127
138Myositis (HP:0100614)1.78661414
139Hyperthyroidism (HP:0000836)1.78214272
140Sparse eyelashes (HP:0000653)1.78211235
141Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.77935792
142Prostate neoplasm (HP:0100787)1.77328273
143Abnormality of the tricuspid valve (HP:0001702)1.76422603
144Personality changes (HP:0000751)1.75671064
145Hypoplasia of the capital femoral epiphysis (HP:0003090)1.74623243
146Poikiloderma (HP:0001029)1.73496719
147IgM deficiency (HP:0002850)1.73051154
148Muscle fiber atrophy (HP:0100295)1.73003085
149Acute encephalopathy (HP:0006846)1.72758705
150Acute necrotizing encephalopathy (HP:0006965)1.72748384
151Upper limb muscle weakness (HP:0003484)1.72742248
152Entropion (HP:0000621)1.72385855
153Exertional dyspnea (HP:0002875)1.71391149
154Progressive hearing impairment (HP:0001730)1.71319947
155Self-mutilation (HP:0000742)1.71171874
156Sloping forehead (HP:0000340)1.71016030
157Abnormality of T cell physiology (HP:0011840)1.71004715
158Myopathic facies (HP:0002058)1.70216906
159Supernumerary spleens (HP:0009799)1.68685266
160Elbow flexion contracture (HP:0002987)1.68409566
161Colon cancer (HP:0003003)1.68370783
162Orthostatic hypotension (HP:0001278)1.68194061
163Abnormal protein glycosylation (HP:0012346)1.67704050
164Abnormal glycosylation (HP:0012345)1.67704050
165Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.67704050
166Abnormal protein N-linked glycosylation (HP:0012347)1.67704050
167Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.66268181
168Overriding aorta (HP:0002623)1.66060530
169Ureteral duplication (HP:0000073)1.65127977
170Patellar dislocation (HP:0002999)1.63845042
171Sensory axonal neuropathy (HP:0003390)1.63063362

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.85058687
2SMG13.57653077
3EIF2AK13.52373462
4VRK23.21302567
5NME22.94019929
6WEE12.87417415
7CDC72.46844947
8PIM22.41682565
9IRAK32.39754701
10SRPK12.22252179
11ICK2.20575214
12TRIB32.15309117
13PLK42.14154721
14IRAK42.12016650
15NEK12.01656005
16BLK1.96567684
17EEF2K1.96178915
18RPS6KA41.92958202
19STK161.92443251
20MAP4K11.92075560
21TESK21.83695783
22TLK11.79985794
23EIF2AK31.79703894
24NEK21.78580546
25PBK1.78347752
26ACVR1B1.66063476
27VRK11.65028654
28TSSK61.64482065
29TTK1.60344145
30EPHA21.58669526
31CDK71.58137550
32MKNK11.57686022
33PLK11.54730779
34BRSK21.52489258
35ARAF1.49986913
36EIF2AK21.48335910
37DYRK31.45285829
38MAP3K141.41469711
39IKBKB1.40438173
40MKNK21.34335616
41ATR1.31514831
42TBK11.29538897
43STK101.28159201
44* AURKB1.24353936
45MST1R1.23954445
46MAP3K111.23850016
47TXK1.23640935
48SIK11.21365378
49PRPF4B1.17290382
50PIM11.15998497
51MAP3K81.14628144
52ZAK1.13434209
53PASK1.12692955
54STK41.12360875
55NME11.10825303
56KDR1.10295874
57LATS21.06067229
58JAK31.05017020
59MST41.04086933
60CDK41.03835004
61CHEK21.03595242
62IKBKE1.01825597
63BRAF1.01172482
64PDK20.98581650
65CDK120.98399793
66PLK30.98191697
67TESK10.97860237
68ZAP700.94907755
69PIK3CG0.93180688
70TYK20.91483996
71AURKA0.90832872
72CHUK0.86104040
73PTK20.85718803
74MAP2K30.85289838
75ILK0.85079381
76RPS6KB20.84975136
77BCKDK0.84885070
78MTOR0.82552343
79ABL20.82257209
80TAF10.80488530
81CHEK10.80156800
82PAK40.79908131
83NEK90.79566317
84AKT20.76667321
85DAPK10.72794505
86TEC0.72018574
87SCYL20.70217188
88PAK10.70037606
89KIT0.68746499
90TAOK20.68590304
91LYN0.67255872
92ALK0.67142738
93FLT30.66766898
94PAK20.66628396
95TAOK30.66034621
96BRSK10.63789564
97RAF10.63417354
98CDK90.63260698
99STK38L0.62933817
100CSNK2A10.62606498
101STK30.61987299
102BTK0.61659616
103CCNB10.60736180
104ATM0.60057357
105LIMK10.57949599
106MARK30.57190237
107ERN10.56244281
108CDK20.55177029
109IRAK10.55066318
110TGFBR10.54887449
111ERBB40.54435770
112CDK10.54183549
113PRKCI0.54135542
114MAP3K90.53127465
115CLK10.52899935
116CSNK2A20.52827433
117TTN0.52307507
118YES10.49137035
119MAP3K30.48951569
120RPS6KA50.48756291
121MAPK110.47872880
122CDK80.45154175
123MAP3K100.43953183
124PKN20.43305515
125LMTK20.42252628
126MAP3K50.41968040
127PRKD30.41658592
128CSF1R0.41556815
129CSK0.41301002
130LRRK20.40725084
131IRAK20.40532074
132NLK0.40471922
133DYRK20.38332959
134BMX0.38294107
135LCK0.38119407
136MAPKAPK20.36594485
137MET0.36275548
138CDK11A0.36109178
139DMPK0.35553481
140MOS0.35484529
141CSNK1E0.34919399
142CDK140.32888130

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.01121625
2Proteasome_Homo sapiens_hsa030503.35135327
3Ribosome_Homo sapiens_hsa030103.31947196
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.31608852
5RNA polymerase_Homo sapiens_hsa030203.27475989
6Mismatch repair_Homo sapiens_hsa034303.26964429
7Base excision repair_Homo sapiens_hsa034102.74421684
8Spliceosome_Homo sapiens_hsa030402.66613151
9Homologous recombination_Homo sapiens_hsa034402.59174330
10RNA transport_Homo sapiens_hsa030132.47592323
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.41675261
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.33517304
13Pyrimidine metabolism_Homo sapiens_hsa002402.31256605
14One carbon pool by folate_Homo sapiens_hsa006702.27436984
15Nucleotide excision repair_Homo sapiens_hsa034202.23868793
16Fanconi anemia pathway_Homo sapiens_hsa034602.01799636
17Cell cycle_Homo sapiens_hsa041101.90356460
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.86289135
19Basal transcription factors_Homo sapiens_hsa030221.66901440
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.66013329
21Carbon metabolism_Homo sapiens_hsa012001.59470077
22Non-homologous end-joining_Homo sapiens_hsa034501.53939638
23RNA degradation_Homo sapiens_hsa030181.51203971
24p53 signaling pathway_Homo sapiens_hsa041151.50768965
25Herpes simplex infection_Homo sapiens_hsa051681.42638999
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.41366866
27Legionellosis_Homo sapiens_hsa051341.37956281
28Epstein-Barr virus infection_Homo sapiens_hsa051691.27988966
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27498583
30Graft-versus-host disease_Homo sapiens_hsa053321.26475117
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.26022150
32N-Glycan biosynthesis_Homo sapiens_hsa005101.24918312
33Pyruvate metabolism_Homo sapiens_hsa006201.23517285
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20989359
35Antigen processing and presentation_Homo sapiens_hsa046121.20565479
36Allograft rejection_Homo sapiens_hsa053301.18576436
37Leishmaniasis_Homo sapiens_hsa051401.17458543
38Purine metabolism_Homo sapiens_hsa002301.12341011
39Folate biosynthesis_Homo sapiens_hsa007901.11696027
40Measles_Homo sapiens_hsa051621.10717209
41Fatty acid elongation_Homo sapiens_hsa000621.10314978
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.08536910
43Bladder cancer_Homo sapiens_hsa052191.07954204
44Central carbon metabolism in cancer_Homo sapiens_hsa052301.07694311
45NOD-like receptor signaling pathway_Homo sapiens_hsa046211.03465638
46mRNA surveillance pathway_Homo sapiens_hsa030151.03276908
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02944925
48Asthma_Homo sapiens_hsa053100.97851632
49Parkinsons disease_Homo sapiens_hsa050120.94168766
50Protein export_Homo sapiens_hsa030600.93175397
51Apoptosis_Homo sapiens_hsa042100.92095379
52Toll-like receptor signaling pathway_Homo sapiens_hsa046200.89046955
53Influenza A_Homo sapiens_hsa051640.87940409
54Intestinal immune network for IgA production_Homo sapiens_hsa046720.87783825
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86110955
56Shigellosis_Homo sapiens_hsa051310.82981178
57Sulfur relay system_Homo sapiens_hsa041220.82691245
58Primary immunodeficiency_Homo sapiens_hsa053400.82020407
59Oxidative phosphorylation_Homo sapiens_hsa001900.77298484
60Pentose phosphate pathway_Homo sapiens_hsa000300.74469468
61Viral carcinogenesis_Homo sapiens_hsa052030.71887782
62Hematopoietic cell lineage_Homo sapiens_hsa046400.71601240
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71338815
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71006093
65Malaria_Homo sapiens_hsa051440.70753006
66Pertussis_Homo sapiens_hsa051330.69310209
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67588484
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67480448
69Vitamin B6 metabolism_Homo sapiens_hsa007500.66449332
70Arginine and proline metabolism_Homo sapiens_hsa003300.66204175
71HTLV-I infection_Homo sapiens_hsa051660.65871713
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63682317
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63231571
74Viral myocarditis_Homo sapiens_hsa054160.61245671
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.60829580
76Systemic lupus erythematosus_Homo sapiens_hsa053220.60463330
77TNF signaling pathway_Homo sapiens_hsa046680.58978567
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.58142846
79Hepatitis B_Homo sapiens_hsa051610.57640920
80Oocyte meiosis_Homo sapiens_hsa041140.56687108
81Type I diabetes mellitus_Homo sapiens_hsa049400.55852715
82Arginine biosynthesis_Homo sapiens_hsa002200.54163831
83Other glycan degradation_Homo sapiens_hsa005110.52499444
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51664804
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51577926
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51562520
87Salmonella infection_Homo sapiens_hsa051320.51415955
88Osteoclast differentiation_Homo sapiens_hsa043800.51313079
89Vibrio cholerae infection_Homo sapiens_hsa051100.50722941
90Autoimmune thyroid disease_Homo sapiens_hsa053200.50531407
91Tuberculosis_Homo sapiens_hsa051520.50256496
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49390458
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48757653
94Metabolic pathways_Homo sapiens_hsa011000.47645772
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47611334
96Small cell lung cancer_Homo sapiens_hsa052220.47262977
97Steroid biosynthesis_Homo sapiens_hsa001000.47232901
98Phenylalanine metabolism_Homo sapiens_hsa003600.46999140
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.46333650
100Selenocompound metabolism_Homo sapiens_hsa004500.45742951
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44690455
102MicroRNAs in cancer_Homo sapiens_hsa052060.44506836
103Lysine degradation_Homo sapiens_hsa003100.44502858
104Sulfur metabolism_Homo sapiens_hsa009200.43222826
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.43095870
106Arachidonic acid metabolism_Homo sapiens_hsa005900.42663961
107Staphylococcus aureus infection_Homo sapiens_hsa051500.41723255
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41599135
109Alzheimers disease_Homo sapiens_hsa050100.40634728
110Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40608286
111Acute myeloid leukemia_Homo sapiens_hsa052210.40594487
112Glutathione metabolism_Homo sapiens_hsa004800.38861489
113Non-small cell lung cancer_Homo sapiens_hsa052230.38234267
114Toxoplasmosis_Homo sapiens_hsa051450.36990922
115Huntingtons disease_Homo sapiens_hsa050160.35881475
116Pancreatic cancer_Homo sapiens_hsa052120.35859136
117Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34250763
118Fructose and mannose metabolism_Homo sapiens_hsa000510.33898858
119B cell receptor signaling pathway_Homo sapiens_hsa046620.33262115
120Galactose metabolism_Homo sapiens_hsa000520.32404698
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32343742
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32309580
123Phagosome_Homo sapiens_hsa041450.31107471
124Thyroid cancer_Homo sapiens_hsa052160.31032225
125Prion diseases_Homo sapiens_hsa050200.30456856
126Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29958190
127Notch signaling pathway_Homo sapiens_hsa043300.29327115
128Rheumatoid arthritis_Homo sapiens_hsa053230.28837961
129Hepatitis C_Homo sapiens_hsa051600.28433468
130Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.27662663
131HIF-1 signaling pathway_Homo sapiens_hsa040660.27637635
132Hippo signaling pathway_Homo sapiens_hsa043900.27032425
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24238366
134Chronic myeloid leukemia_Homo sapiens_hsa052200.24178546
135Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23250313
136Prostate cancer_Homo sapiens_hsa052150.23171264
137AMPK signaling pathway_Homo sapiens_hsa041520.22956062
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22703539
139Lysosome_Homo sapiens_hsa041420.22642719
140Fatty acid metabolism_Homo sapiens_hsa012120.22358104
141Biosynthesis of amino acids_Homo sapiens_hsa012300.22272923
142Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21791256
143Insulin signaling pathway_Homo sapiens_hsa049100.21125711
144AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.20294844
145Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19190569

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