CCDC87

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium movement (GO:0003341)9.31871704
2cell-cell recognition (GO:0009988)9.30574150
3reproduction (GO:0000003)9.07998613
4binding of sperm to zona pellucida (GO:0007339)9.04584590
5piRNA metabolic process (GO:0034587)8.95275524
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.51165537
7spermatid development (GO:0007286)8.44140010
8regulation of cilium movement (GO:0003352)8.11520089
9male meiosis (GO:0007140)7.88191464
10single fertilization (GO:0007338)7.24441901
11regulation of sarcomere organization (GO:0060297)7.05951762
12synaptonemal complex organization (GO:0070193)6.98310725
13sperm capacitation (GO:0048240)6.73518230
14synaptonemal complex assembly (GO:0007130)6.58607303
15plasma membrane repair (GO:0001778)6.15323178
16fertilization (GO:0009566)6.01752590
17ventricular system development (GO:0021591)5.85838491
18negative regulation of inclusion body assembly (GO:0090084)5.78172476
19negative regulation of nitric-oxide synthase activity (GO:0051001)5.61036442
20negative regulation of protein localization to cell surface (GO:2000009)5.57851201
21DNA methylation involved in gamete generation (GO:0043046)5.55051095
22spermatogenesis (GO:0007283)5.44995807
23negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.44302347
24calcium ion-dependent exocytosis (GO:0017156)5.43337218
25male gamete generation (GO:0048232)5.42806341
26male meiosis I (GO:0007141)5.41004128
27microtubule severing (GO:0051013)5.35886858
28microtubule depolymerization (GO:0007019)5.32698682
29negative regulation of muscle hypertrophy (GO:0014741)5.31064320
30protein localization to cilium (GO:0061512)5.30951587
31regulation of microtubule-based movement (GO:0060632)5.09936239
32negative regulation of cell size (GO:0045792)5.03390107
33gamete generation (GO:0007276)5.02255544
34organic cation transport (GO:0015695)4.87629018
35positive regulation of myotube differentiation (GO:0010831)4.87531811
36cell recognition (GO:0008037)4.84744668
37cellular process involved in reproduction in multicellular organism (GO:0022412)4.83611741
38germ cell development (GO:0007281)4.79498062
39positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc4.79195899
40regulation of inclusion body assembly (GO:0090083)4.68706930
41negative regulation of potassium ion transmembrane transport (GO:1901380)4.67669567
42ribonucleoprotein complex disassembly (GO:0032988)4.64979448
43spermatid nucleus differentiation (GO:0007289)4.63017105
44meiotic nuclear division (GO:0007126)4.60302583
45chromosome organization involved in meiosis (GO:0070192)4.55307176
46regulation of skeletal muscle contraction (GO:0014819)4.54130434
47activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO4.50770743
48negative regulation of cardiac muscle hypertrophy (GO:0010614)4.49901505
49regulation of action potential (GO:0098900)4.49579647
50response to pheromone (GO:0019236)4.39908623
51rRNA methylation (GO:0031167)4.37265875
52DNA synthesis involved in DNA repair (GO:0000731)4.35592764
53axoneme assembly (GO:0035082)4.35095579
54meiosis I (GO:0007127)4.27461783
55histone H3-K9 demethylation (GO:0033169)4.26521031
56negative regulation of cardiac muscle tissue growth (GO:0055022)4.24788894
57negative regulation of heart growth (GO:0061117)4.24788894
58positive regulation of microtubule polymerization (GO:0031116)4.21909925
59left/right pattern formation (GO:0060972)4.20224909
60protein polyglutamylation (GO:0018095)4.16128346
61regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.12925098
62intraciliary transport (GO:0042073)4.08774786
63meiotic cell cycle (GO:0051321)4.01053610
64rRNA modification (GO:0000154)3.97022813
65multicellular organismal reproductive process (GO:0048609)3.94320373
66myoblast fusion (GO:0007520)3.80715671
67regulation of p38MAPK cascade (GO:1900744)3.80680659
68negative regulation of cardiac muscle tissue development (GO:0055026)3.74271979
69organelle disassembly (GO:1903008)3.71543161
70cilium morphogenesis (GO:0060271)3.68784370
71microtubule-based movement (GO:0007018)3.68634742
72cilium organization (GO:0044782)3.66659440
73protein targeting to Golgi (GO:0000042)3.65881539
74retrograde transport, vesicle recycling within Golgi (GO:0000301)3.59913190
75seminiferous tubule development (GO:0072520)3.58283006
76sexual reproduction (GO:0019953)3.57199220
77phosphatidylethanolamine biosynthetic process (GO:0006646)3.56210791
78cilium assembly (GO:0042384)3.55467725
79establishment of protein localization to Golgi (GO:0072600)3.55398076
80centriole replication (GO:0007099)3.47519026
81striated muscle atrophy (GO:0014891)3.47242590
82membrane raft organization (GO:0031579)3.38076912
83centriole assembly (GO:0098534)3.37883418
84syncytium formation by plasma membrane fusion (GO:0000768)3.29659674
85nucleoside diphosphate phosphorylation (GO:0006165)3.27936074
86phosphatidylethanolamine metabolic process (GO:0046337)3.26964291
87gene silencing by RNA (GO:0031047)3.26774638
88resolution of meiotic recombination intermediates (GO:0000712)3.26279726
89cellular component assembly involved in morphogenesis (GO:0010927)3.26054284
90chaperone-mediated protein complex assembly (GO:0051131)3.21444694
91negative regulation of monooxygenase activity (GO:0032769)3.19459079
92membrane assembly (GO:0071709)3.15257814
93regulation of meiosis I (GO:0060631)3.14078371
94negative regulation of organelle assembly (GO:1902116)3.13216688
95regulation of cardiac muscle cell differentiation (GO:2000725)3.13100756
96multicellular organismal development (GO:0007275)3.12796788
97glycerol ether metabolic process (GO:0006662)3.12035570
98regulation of chromatin binding (GO:0035561)3.08740997
99monoubiquitinated protein deubiquitination (GO:0035520)3.07960978
100embryonic viscerocranium morphogenesis (GO:0048703)3.07852303
101cytoplasmic microtubule organization (GO:0031122)3.07423315
102cellular ketone body metabolic process (GO:0046950)3.07259110
103positive regulation of skeletal muscle tissue development (GO:0048643)3.06251059
104nucleus organization (GO:0006997)3.06188285
105genitalia morphogenesis (GO:0035112)3.05200527
106amino-acid betaine transport (GO:0015838)3.03898442
107carnitine transport (GO:0015879)3.03898442
108peptidyl-lysine dimethylation (GO:0018027)3.00134942
109muscle atrophy (GO:0014889)2.99481177
110carnitine transmembrane transport (GO:1902603)2.98717730
111polyol catabolic process (GO:0046174)2.96554059
112embryonic foregut morphogenesis (GO:0048617)2.94866049
113alditol metabolic process (GO:0019400)2.92919947
114ventricular cardiac muscle cell action potential (GO:0086005)2.92542823
115ether metabolic process (GO:0018904)2.88248814
116microtubule polymerization or depolymerization (GO:0031109)2.86630536
117regulation of centriole replication (GO:0046599)2.86473011
118meiotic cell cycle process (GO:1903046)2.79924935
119lactate metabolic process (GO:0006089)2.79393122
120single strand break repair (GO:0000012)2.75774854
121protein K11-linked deubiquitination (GO:0035871)2.75510750
122glycerol metabolic process (GO:0006071)2.73188041
123peptidyl-glutamic acid modification (GO:0018200)2.68246579
124GTP biosynthetic process (GO:0006183)2.63991109
125protein refolding (GO:0042026)2.57248605
126left/right axis specification (GO:0070986)2.56482540
127peptidyl-threonine dephosphorylation (GO:0035970)2.55236955
128synapsis (GO:0007129)2.53175140
129chromosome condensation (GO:0030261)2.52183854
130microtubule bundle formation (GO:0001578)2.51556467
131glycolytic process (GO:0006096)2.43464199
132regulation of cilium assembly (GO:1902017)2.40003626
133DNA packaging (GO:0006323)2.37628987
134membrane depolarization during action potential (GO:0086010)2.34180261
135regulation of spindle checkpoint (GO:0090231)2.31820567
136UTP biosynthetic process (GO:0006228)2.31013524
137gene silencing (GO:0016458)2.30641438
138cilium or flagellum-dependent cell motility (GO:0001539)14.0367107
139fusion of sperm to egg plasma membrane (GO:0007342)13.1942017
140cell wall macromolecule catabolic process (GO:0016998)11.7458105
141cell wall macromolecule metabolic process (GO:0044036)11.7458105
142axonemal dynein complex assembly (GO:0070286)11.4030326
143multicellular organism reproduction (GO:0032504)11.0474104
144sperm motility (GO:0030317)10.9640793
145sperm-egg recognition (GO:0035036)10.4118784
146acrosome reaction (GO:0007340)10.2456657
147epithelial cilium movement (GO:0003351)10.2290934
148acrosome assembly (GO:0001675)10.2001686
149plasma membrane fusion (GO:0045026)10.1245076
150motile cilium assembly (GO:0044458)10.0909453

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.82500308
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.99884823
3EZH2_22144423_ChIP-Seq_EOC_Human5.21033717
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.67719896
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.53632331
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.77863683
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.38766767
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.31162876
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.29400311
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.15982597
11FUS_26573619_Chip-Seq_HEK293_Human2.12434918
12VDR_22108803_ChIP-Seq_LS180_Human2.10806828
13GATA1_26923725_Chip-Seq_HPCs_Mouse2.05198547
14ERA_21632823_ChIP-Seq_H3396_Human2.01865271
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.98196175
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.98196175
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.98196175
18STAT6_21828071_ChIP-Seq_BEAS2B_Human1.96874420
19YY1_22570637_ChIP-Seq_MALME-3M_Human1.95082759
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.91534774
21CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.89235431
22TDRD3_21172665_ChIP-Seq_MCF-7_Human1.85917697
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.85533728
24ELK4_26923725_Chip-Seq_MESODERM_Mouse1.85218998
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.84243348
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.80635726
27ZNF274_21170338_ChIP-Seq_K562_Hela1.78013254
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76529103
29ELF1_20517297_ChIP-Seq_JURKAT_Human1.74767778
30REST_21632747_ChIP-Seq_MESCs_Mouse1.72489316
31KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.72477698
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72137726
33EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.70870612
34RAC3_21632823_ChIP-Seq_H3396_Human1.67374317
35MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.65404997
36TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.64998440
37ERG_20517297_ChIP-Seq_VCAP_Human1.63420754
38E2F1_20622854_ChIP-Seq_HELA_Human1.62935152
39FOXM1_23109430_ChIP-Seq_U2OS_Human1.61251930
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58206510
41EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.57060562
42KAP1_22055183_ChIP-Seq_ESCs_Mouse1.56602486
43PHF8_20622854_ChIP-Seq_HELA_Human1.56503685
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.56081597
45SMC4_20622854_ChIP-Seq_HELA_Human1.54078215
46AUTS2_25519132_ChIP-Seq_293T-REX_Human1.52707536
47RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.52031753
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.50923600
49KDM2B_26808549_Chip-Seq_REH_Human1.50092659
50WDR5_24793694_ChIP-Seq_LNCAP_Human1.49707993
51CTCF_27219007_Chip-Seq_Bcells_Human1.48075751
52P68_20966046_ChIP-Seq_HELA_Human1.44885862
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44769145
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.44439873
55TAL1_26923725_Chip-Seq_HPCs_Mouse1.44112057
56GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.42974380
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41892741
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41727315
59MYC_19829295_ChIP-Seq_ESCs_Human1.40165922
60STAT1_17558387_ChIP-Seq_HELA_Human1.39934843
61P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.38431687
62PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.37819869
63NFIB_24661679_ChIP-Seq_LUNG_Mouse1.36852780
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36689866
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36689866
66OCT4_20526341_ChIP-Seq_ESCs_Human1.35119515
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34520311
68RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.34473531
69EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.33867097
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31647489
71FLI1_21867929_ChIP-Seq_TH2_Mouse1.30840519
72SOX11_22085726_ChIP-Seq_ESNs_Mouse1.28600950
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.27712611
74* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.27014804
75TP63_22573176_ChIP-Seq_HFKS_Human1.26781549
76CBP_20019798_ChIP-Seq_JUKART_Human1.26608077
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26608077
78PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.26541497
79RNF2_27304074_Chip-Seq_NSC_Mouse1.25438122
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25402684
81GATA3_21867929_ChIP-Seq_CD8_Mouse1.25203862
82FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24867267
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.23125973
84RUNX1_26923725_Chip-Seq_HPCs_Mouse1.22977055
85TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21166846
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20889296
87RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20480579
88HNFA_21074721_ChIP-Seq_CACO-2_Human1.20376117
89LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.18590742
90* TAF2_19829295_ChIP-Seq_ESCs_Human1.18469337
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18366216
92NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17279720
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16719761
94ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16604531
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16006321
96DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15358678
97CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.15220033
98BCL6_27268052_Chip-Seq_Bcells_Human1.14963758
99FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.11995274
100POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.11832368
101CSB_26484114_Chip-Seq_FIBROBLAST_Human1.11325624
102P53_22387025_ChIP-Seq_ESCs_Mouse1.11251828
103* NANOG_20526341_ChIP-Seq_ESCs_Human1.10832675
104TAF15_26573619_Chip-Seq_HEK293_Human1.10712787
105GATA3_21867929_ChIP-Seq_TH1_Mouse1.10459748
106* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.10407119
107OCT4_18555785_Chip-Seq_ESCs_Mouse1.10316448
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09039789
109GF1_26923725_Chip-Seq_HPCs_Mouse1.08596443
110CMYC_18555785_Chip-Seq_ESCs_Mouse1.08587414
111CRX_20693478_ChIP-Seq_RETINA_Mouse1.08431198
112PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08190873
113* TET1_21451524_ChIP-Seq_MESCs_Mouse1.08021118
114HOXB7_26014856_ChIP-Seq_BT474_Human1.07040008
115EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06672514
116BCOR_27268052_Chip-Seq_Bcells_Human1.06083283
117CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06072798
118CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05909952
119P300_18555785_Chip-Seq_ESCs_Mouse1.05492245
120NANOG_21062744_ChIP-ChIP_HESCs_Human1.05453528
121SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04500884
122SMAD4_21799915_ChIP-Seq_A2780_Human1.04190779
123PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03434535
124CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03143125
125P300_27268052_Chip-Seq_Bcells_Human1.02937644
126NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.02806980
127GATA3_21878914_ChIP-Seq_MCF-7_Human1.02499611
128CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01633930
129SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01286196
130KLF4_18555785_Chip-Seq_ESCs_Mouse1.00970136
131SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.00193892
132* CTCF_20526341_ChIP-Seq_ESCs_Human0.99268405
133OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97810919
134SPI1_20517297_ChIP-Seq_HL60_Human0.97632887
135P53_21459846_ChIP-Seq_SAOS-2_Human0.97329825
136ESRRB_18555785_Chip-Seq_ESCs_Mouse0.97123962
137PHF8_20622853_ChIP-Seq_HELA_Human0.97011509
138GF1B_26923725_Chip-Seq_HPCs_Mouse0.96925946
139PKCTHETA_26484144_Chip-Seq_BREAST_Human0.96597868
140SMAD4_21741376_ChIP-Seq_EPCs_Human0.96510666
141CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96108903
142NFYB_21822215_ChIP-Seq_K562_Human0.96064368
143FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95895555
144AR_25329375_ChIP-Seq_VCAP_Human0.95754123
145ER_23166858_ChIP-Seq_MCF-7_Human0.95512294
146CBX2_22325352_ChIP-Seq_293T-Rex_Human0.95460906
147RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95350782
148NCOR_22424771_ChIP-Seq_293T_Human0.94975457
149SOX2_18555785_Chip-Seq_ESCs_Mouse0.94856908
150VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94833458
151EZH2_27294783_Chip-Seq_NPCs_Mouse0.93633633
152TCF4_23295773_ChIP-Seq_U87_Human0.93569779
153SUZ12_27294783_Chip-Seq_ESCs_Mouse0.93296040
154STAT3_18555785_Chip-Seq_ESCs_Mouse0.93021269
155SALL1_21062744_ChIP-ChIP_HESCs_Human0.92436729
156CTCF_18555785_Chip-Seq_ESCs_Mouse0.92411292
157E2F1_18555785_Chip-Seq_ESCs_Mouse0.91528759
158ARNT_22903824_ChIP-Seq_MCF-7_Human0.91195201
159SMAD3_21741376_ChIP-Seq_EPCs_Human0.90541115
160IGF1R_20145208_ChIP-Seq_DFB_Human0.90173783
161RUNX1_27457419_Chip-Seq_LIVER_Mouse0.90057841
162SOX9_26525672_Chip-Seq_HEART_Mouse0.90037409
163TBL1_22424771_ChIP-Seq_293T_Human0.89438921
164CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.89201969
165RAD21_21589869_ChIP-Seq_MESCs_Mouse0.88487108
166SMAD3_21741376_ChIP-Seq_ESCs_Human0.88391390
167PU1_27457419_Chip-Seq_LIVER_Mouse0.88386643
168AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88230131
169PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.88080476
170OCT1_27270436_Chip-Seq_PROSTATE_Human0.86777985
171SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.86592666

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.42699536
2MP0001929_abnormal_gametogenesis4.84713609
3MP0008877_abnormal_DNA_methylation4.72507937
4MP0002653_abnormal_ependyma_morphology4.13488307
5MP0002210_abnormal_sex_determination3.31090355
6MP0001984_abnormal_olfaction3.26982763
7MP0000749_muscle_degeneration3.18778692
8MP0000678_abnormal_parathyroid_gland3.07067948
9MP0002161_abnormal_fertility/fecundity2.96977424
10MP0010030_abnormal_orbit_morphology2.95087678
11MP0001145_abnormal_male_reproductive2.78899560
12MP0000751_myopathy2.73668856
13MP0002249_abnormal_larynx_morphology2.72540434
14MP0005623_abnormal_meninges_morphology2.68334181
15MP0000653_abnormal_sex_gland2.47850455
16MP0009046_muscle_twitch2.38802261
17MP0003718_maternal_effect2.28317188
18MP0005410_abnormal_fertilization13.7056815
19MP0005248_abnormal_Harderian_gland1.92771121
20MP0002160_abnormal_reproductive_system1.88478759
21MP0001348_abnormal_lacrimal_gland1.70422220
22MP0002102_abnormal_ear_morphology1.70077031
23MP0004233_abnormal_muscle_weight1.58302617
24MP0003693_abnormal_embryo_hatching1.57404361
25MP0003283_abnormal_digestive_organ1.49327724
26MP0003646_muscle_fatigue1.31124629
27MP0005083_abnormal_biliary_tract1.29030752
28MP0005394_taste/olfaction_phenotype1.28818711
29MP0005499_abnormal_olfactory_system1.28818711
30MP0004270_analgesia1.24653497
31MP0000049_abnormal_middle_ear1.23498342
32MP0008789_abnormal_olfactory_epithelium1.23357712
33MP0002282_abnormal_trachea_morphology1.20477008
34MP0001873_stomach_inflammation1.20418726
35MP0005551_abnormal_eye_electrophysiolog1.20161732
36MP0000467_abnormal_esophagus_morphology1.17422264
37MP0003077_abnormal_cell_cycle1.16915874
38MP0009053_abnormal_anal_canal1.15569616
39MP0004859_abnormal_synaptic_plasticity1.12633211
40MP0003635_abnormal_synaptic_transmissio1.12630702
41MP0002822_catalepsy1.11989276
42MP0006292_abnormal_olfactory_placode1.10309552
43MP0005670_abnormal_white_adipose1.05682404
44MP0004036_abnormal_muscle_relaxation1.05462654
45MP0002234_abnormal_pharynx_morphology1.05094158
46MP0004084_abnormal_cardiac_muscle1.04372323
47MP0009780_abnormal_chondrocyte_physiolo1.03680244
48MP0003119_abnormal_digestive_system1.00015115
49MP0005423_abnormal_somatic_nervous0.97860928
50MP0003880_abnormal_central_pattern0.97169697
51MP0002089_abnormal_postnatal_growth/wei0.95773449
52MP0002127_abnormal_cardiovascular_syste0.93962461
53MP0000750_abnormal_muscle_regeneration0.91855856
54MP0001270_distended_abdomen0.90146266
55MP0005379_endocrine/exocrine_gland_phen0.89229035
56MP0001919_abnormal_reproductive_system0.88506168
57MP0002063_abnormal_learning/memory/cond0.87080834
58MP0001486_abnormal_startle_reflex0.86612474
59MP0001765_abnormal_ion_homeostasis0.85153998
60MP0002572_abnormal_emotion/affect_behav0.85062889
61MP0008058_abnormal_DNA_repair0.85061683
62MP0004811_abnormal_neuron_physiology0.84500610
63MP0005389_reproductive_system_phenotype0.82719252
64MP0003329_amyloid_beta_deposits0.80860108
65MP0005377_hearing/vestibular/ear_phenot0.79519483
66MP0003878_abnormal_ear_physiology0.79519483
67MP0003011_delayed_dark_adaptation0.78322249
68MP0001529_abnormal_vocalization0.75578162
69MP0002272_abnormal_nervous_system0.75470171
70MP0010368_abnormal_lymphatic_system0.75348835
71MP0001666_abnormal_nutrient_absorption0.75303323
72MP0005647_abnormal_sex_gland0.74157156
73MP0000579_abnormal_nail_morphology0.73335458
74MP0000733_abnormal_muscle_development0.73138950
75MP0002152_abnormal_brain_morphology0.72892692
76MP0002557_abnormal_social/conspecific_i0.72882940
77MP0000566_synostosis0.72101118
78MP0002064_seizures0.71709062
79MP0002734_abnormal_mechanical_nocicepti0.71135164
80MP0002928_abnormal_bile_duct0.70961831
81MP0009745_abnormal_behavioral_response0.70944743
82MP0002752_abnormal_somatic_nervous0.70596669
83MP0002882_abnormal_neuron_morphology0.69891468
84MP0003879_abnormal_hair_cell0.69434849
85MP0001293_anophthalmia0.68659963
86MP0002229_neurodegeneration0.68376262
87MP0003111_abnormal_nucleus_morphology0.68362345
88MP0000778_abnormal_nervous_system0.68045248
89MP0005253_abnormal_eye_physiology0.67086730
90MP0000955_abnormal_spinal_cord0.66148486
91MP0003861_abnormal_nervous_system0.64496734
92MP0005395_other_phenotype0.64425216
93MP0005645_abnormal_hypothalamus_physiol0.62786485
94MP0002092_abnormal_eye_morphology0.62095347
95MP0000759_abnormal_skeletal_muscle0.60826130
96MP0002184_abnormal_innervation0.60400022
97MP0005409_darkened_coat_color0.59769457
98MP0004742_abnormal_vestibular_system0.59186922
99MP0001968_abnormal_touch/_nociception0.58970301
100MP0003935_abnormal_craniofacial_develop0.58167568
101MP0005451_abnormal_body_composition0.58165186
102MP0001485_abnormal_pinna_reflex0.58079076
103MP0002139_abnormal_hepatobiliary_system0.58068859
104MP0008995_early_reproductive_senescence0.57814902
105MP0005195_abnormal_posterior_eye0.57236041
106MP0000003_abnormal_adipose_tissue0.56280748
107MP0003385_abnormal_body_wall0.56051384
108MP0003938_abnormal_ear_development0.55865004
109MP0003787_abnormal_imprinting0.55115951
110MP0003633_abnormal_nervous_system0.55079226
111MP0003959_abnormal_lean_body0.54800365
112MP0000647_abnormal_sebaceous_gland0.54683254
113MP0002932_abnormal_joint_morphology0.54283741
114MP0010094_abnormal_chromosome_stability0.54091541
115MP0002085_abnormal_embryonic_tissue0.53803337
116MP0001324_abnormal_eye_pigmentation0.52912578
117MP0001664_abnormal_digestion0.52554560
118MP0005391_vision/eye_phenotype0.51927853
119MP0002067_abnormal_sensory_capabilities0.51853560
120MP0000358_abnormal_cell_content/0.51832769
121MP0000681_abnormal_thyroid_gland0.51703753
122MP0002108_abnormal_muscle_morphology0.51599958
123MP0003631_nervous_system_phenotype0.51218425
124MP0002254_reproductive_system_inflammat0.50888977
125MP0002837_dystrophic_cardiac_calcinosis0.49944046
126MP0006072_abnormal_retinal_apoptosis0.49205044
127MP0000383_abnormal_hair_follicle0.48267262
128MP0003115_abnormal_respiratory_system0.47860619
129MP0003890_abnormal_embryonic-extraembry0.47102364
130MP0001440_abnormal_grooming_behavior0.46817459
131MP0008057_abnormal_DNA_replication0.46771900
132MP0006276_abnormal_autonomic_nervous0.45460727
133MP0002066_abnormal_motor_capabilities/c0.44013886
134MP0001963_abnormal_hearing_physiology0.43379804
135MP0005535_abnormal_body_temperature0.41328954
136MP0003699_abnormal_female_reproductive0.41128037
137MP0003634_abnormal_glial_cell0.40859647
138MP0008569_lethality_at_weaning0.40789583
139MP0002269_muscular_atrophy0.40458667
140MP0000534_abnormal_ureter_morphology0.40248578
141MP0003950_abnormal_plasma_membrane0.39625015
142MP0003136_yellow_coat_color0.39510340
143MP0000569_abnormal_digit_pigmentation0.38022177
144MP0000631_abnormal_neuroendocrine_gland0.37628347
145MP0002233_abnormal_nose_morphology0.37177843
146MP0001764_abnormal_homeostasis0.36809638
147MP0000427_abnormal_hair_cycle0.35267012
148MP0000026_abnormal_inner_ear0.34872879
149MP0001119_abnormal_female_reproductive0.34630086
150MP0002736_abnormal_nociception_after0.33131565
151MP0001502_abnormal_circadian_rhythm0.32874869
152MP0008872_abnormal_physiological_respon0.32091613
153MP0001905_abnormal_dopamine_level0.31865841

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.81054078
2Abnormal respiratory epithelium morphology (HP:0012253)8.90492156
3Abnormal respiratory motile cilium morphology (HP:0005938)8.90492156
4Rhinitis (HP:0012384)8.32646287
5Abnormal ciliary motility (HP:0012262)8.10510803
6Calf muscle hypertrophy (HP:0008981)7.21434163
7Chronic bronchitis (HP:0004469)7.16702039
8Asymmetric septal hypertrophy (HP:0001670)6.79521527
9Muscle hypertrophy of the lower extremities (HP:0008968)6.42726134
10Abnormality of the left ventricular outflow tract (HP:0011103)6.21072791
11Subaortic stenosis (HP:0001682)6.21072791
12Nasal polyposis (HP:0100582)6.03744599
13Infertility (HP:0000789)5.59399023
14Exercise-induced myalgia (HP:0003738)5.48532178
15Exercise-induced muscle cramps (HP:0003710)5.01361213
16Hypoplasia of the thymus (HP:0000778)4.96076278
17Abnormality of the nasal mucosa (HP:0000433)4.91629624
18Bronchiectasis (HP:0002110)4.78494463
19Bronchitis (HP:0012387)4.20067769
20Nephronophthisis (HP:0000090)4.16190050
21Severe visual impairment (HP:0001141)3.86092991
22Sudden death (HP:0001699)3.71922577
23Medial flaring of the eyebrow (HP:0010747)3.52524580
24Renal cortical cysts (HP:0000803)3.50397111
25Myotonia (HP:0002486)3.44245994
26Attenuation of retinal blood vessels (HP:0007843)3.39434102
27Brushfield spots (HP:0001088)3.26227089
28Recurrent sinusitis (HP:0011108)3.23449588
29Recurrent otitis media (HP:0000403)3.20031692
30Abnormality of the renal cortex (HP:0011035)3.17073930
31Turricephaly (HP:0000262)3.13009263
32Muscle stiffness (HP:0003552)3.10890505
33Abnormality of the renal medulla (HP:0100957)3.10701307
34Resting tremor (HP:0002322)3.08527556
35Male infertility (HP:0003251)3.03933119
36Molar tooth sign on MRI (HP:0002419)2.94968478
37Abnormality of midbrain morphology (HP:0002418)2.94968478
38Abnormality of the calf musculature (HP:0001430)2.90498481
39Gait imbalance (HP:0002141)2.82552047
40Flattened epiphyses (HP:0003071)2.81557909
41Poor suck (HP:0002033)2.73620915
42Congenital primary aphakia (HP:0007707)2.72678927
43Short nail (HP:0001799)2.68779235
44Tubulointerstitial nephritis (HP:0001970)2.59230553
45Distal lower limb muscle weakness (HP:0009053)2.46180183
46Abnormality of the lower motor neuron (HP:0002366)2.39064688
47Gowers sign (HP:0003391)2.36240887
48Prolonged QT interval (HP:0001657)2.34309831
49Abnormal spermatogenesis (HP:0008669)2.33925454
50Nephrogenic diabetes insipidus (HP:0009806)2.33887719
51Chronic sinusitis (HP:0011109)2.27859582
52Retinal dysplasia (HP:0007973)2.27400082
53Aplasia/Hypoplasia of the thymus (HP:0010515)2.27332707
54Cone-rod dystrophy (HP:0000548)2.25380247
55Abnormal rod and cone electroretinograms (HP:0008323)2.24631241
56Tubular atrophy (HP:0000092)2.24536389
57Recurrent bronchitis (HP:0002837)2.22311589
58Unilateral renal agenesis (HP:0000122)2.14712926
59Increased serum pyruvate (HP:0003542)2.12943490
60Pili torti (HP:0003777)2.12681018
61Menstrual irregularities (HP:0000858)2.11840648
62Poor coordination (HP:0002370)2.10434539
63Aplasia/Hypoplasia of the earlobes (HP:0009906)2.09001050
64Vaginal atresia (HP:0000148)2.08215250
65Double outlet right ventricle (HP:0001719)2.07276268
66Congenital malformation of the right heart (HP:0011723)2.07276268
67Arterial tortuosity (HP:0005116)2.06766704
68Genital tract atresia (HP:0001827)2.06408692
69Impulsivity (HP:0100710)2.03952519
70Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.5767508
71Dynein arm defect of respiratory motile cilia (HP:0012255)11.6402407
72Absent/shortened dynein arms (HP:0200106)11.6402407
73Tubulointerstitial abnormality (HP:0001969)1.98598239
74Postaxial foot polydactyly (HP:0001830)1.97330576
75Postaxial hand polydactyly (HP:0001162)1.95891837
76Clitoromegaly (HP:0000057)1.93751276
77Palpebral edema (HP:0100540)1.92565283
78Aplasia/Hypoplasia of the lens (HP:0008063)1.91858699
79Oligodactyly (hands) (HP:0001180)1.91853420
80Hyperkalemia (HP:0002153)1.91639542
81Gonadotropin excess (HP:0000837)1.91174941
82Horizontal nystagmus (HP:0000666)1.90511342
83Azoospermia (HP:0000027)1.89769455
84Abnormal cartilage morphology (HP:0002763)1.87168438
85Hypoplastic ischia (HP:0003175)1.86214751
86Abnormal biliary tract morphology (HP:0012440)1.84538027
87Pancreatic fibrosis (HP:0100732)1.82246458
88Congenital hepatic fibrosis (HP:0002612)1.82208236
89Oculomotor apraxia (HP:0000657)1.81509353
90Hypoalbuminemia (HP:0003073)1.81218656
91Abnormal albumin level (HP:0012116)1.81218656
92Abnormality of glycolysis (HP:0004366)1.80573924
93Upper limb muscle weakness (HP:0003484)1.77035395
94Bicornuate uterus (HP:0000813)1.76109345
95Stage 5 chronic kidney disease (HP:0003774)1.73901833
96Sclerocornea (HP:0000647)1.73480021
97Generalized aminoaciduria (HP:0002909)1.72546803
98Increased corneal curvature (HP:0100692)1.72391992
99Keratoconus (HP:0000563)1.72391992
100Abnormality of the thymus (HP:0000777)1.71524523
101Vascular tortuosity (HP:0004948)1.71047184
102Abnormality of the aortic arch (HP:0012303)1.68910243
103Renovascular hypertension (HP:0100817)1.68676459
104Heterotopia (HP:0002282)1.68583315
105Muscle fiber atrophy (HP:0100295)1.67763003
106Neck muscle weakness (HP:0000467)1.67426665
107Enlarged epiphyses (HP:0010580)1.66881981
108Skin nodule (HP:0200036)1.66805150
109Abnormality of the neuromuscular junction (HP:0003398)1.66740043
110Fatigable weakness (HP:0003473)1.66740043
111Pendular nystagmus (HP:0012043)1.66485413
112Sensory axonal neuropathy (HP:0003390)1.66318108
113Amyotrophic lateral sclerosis (HP:0007354)1.65619407
114Abnormality of dentin (HP:0010299)1.64494130
115Spastic tetraparesis (HP:0001285)1.63661839
116True hermaphroditism (HP:0010459)1.62567458
117Type 2 muscle fiber atrophy (HP:0003554)1.62440774
118Fibular hypoplasia (HP:0003038)1.62375719
119Abnormality of ocular smooth pursuit (HP:0000617)1.62032286
120Truncal obesity (HP:0001956)1.61908235
121Abnormality of the phalanges of the hallux (HP:0010057)1.60488780
122Microglossia (HP:0000171)1.60035341
123Aplasia/Hypoplasia of the tongue (HP:0010295)1.59565760
124Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.59387140
125Type II lissencephaly (HP:0007260)1.59227568
126Anencephaly (HP:0002323)1.58706624
127Hypercholesterolemia (HP:0003124)1.58289191
128Cerebellar dysplasia (HP:0007033)1.57923651
129Abnormal gallbladder physiology (HP:0012438)1.57038448
130Cholecystitis (HP:0001082)1.57038448
131Supernumerary spleens (HP:0009799)1.56550438
132Abnormality of permanent molar morphology (HP:0011071)1.54595763
133Abnormality of the dental root (HP:0006486)1.54595763
134Taurodontia (HP:0000679)1.54595763
135Decreased central vision (HP:0007663)1.53775682
136Absent epiphyses (HP:0010577)1.53626052
137Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.53626052
138Abdominal situs inversus (HP:0003363)1.53466361
139Abnormality of abdominal situs (HP:0011620)1.53466361
140Short ribs (HP:0000773)1.50833367
141Cystic liver disease (HP:0006706)1.50244084
142Hyporeflexia of lower limbs (HP:0002600)1.49720205
143Abnormality of saccadic eye movements (HP:0000570)1.48668835
144Renal dysplasia (HP:0000110)1.47428520
145Dyschromatopsia (HP:0007641)1.46062278
146Abnormality of molar (HP:0011077)1.45752348
147Abnormality of molar morphology (HP:0011070)1.45752348
148Abnormality of the dental pulp (HP:0006479)1.45180595
149Tongue fasciculations (HP:0001308)1.44206655
150Tubulointerstitial fibrosis (HP:0005576)1.44079531
151Bony spicule pigmentary retinopathy (HP:0007737)1.43514815
152Progressive cerebellar ataxia (HP:0002073)1.43120472
153Polydipsia (HP:0001959)1.41866877
154Abnormal drinking behavior (HP:0030082)1.41866877
155Pancreatic cysts (HP:0001737)1.41409038
156Hemiparesis (HP:0001269)1.40674129
157Neurofibrillary tangles (HP:0002185)1.39597154
158Insomnia (HP:0100785)1.39322782
159Abnormal biliary tract physiology (HP:0012439)1.39002877
160Bile duct proliferation (HP:0001408)1.39002877
161Median cleft lip (HP:0000161)1.37333597
162Impaired smooth pursuit (HP:0007772)1.37300522
163Retinitis pigmentosa (HP:0000510)1.36291647
164Bell-shaped thorax (HP:0001591)1.35830246
165Occipital encephalocele (HP:0002085)1.35588077
166Choroideremia (HP:0001139)1.34152608
167Hypoplasia of the capital femoral epiphysis (HP:0003090)1.33367200
168Muscle fibrillation (HP:0010546)1.33013185
169Cerebral inclusion bodies (HP:0100314)1.32410397
170J-shaped sella turcica (HP:0002680)1.30788537
171Chronic hepatic failure (HP:0100626)1.30749952
172Gaze-evoked nystagmus (HP:0000640)1.29563584
173Facial cleft (HP:0002006)1.29453839

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.35948624
2PDK48.35948624
3PDK25.29638905
4TESK14.28188941
5CDK84.05222803
6PRKD34.02703678
7ICK3.46706449
8MUSK3.33255991
9MAP4K23.21154873
10INSRR3.04902025
11PNCK2.66321407
12DDR22.63751510
13STK392.49219448
14WNK42.45938049
15MET2.33955024
16PTK2B2.27898081
17TAF12.04864886
18MST1R1.85415377
19CDK91.62391356
20STK381.49670516
21PIK3CG1.45915187
22BRSK11.43698897
23BRD41.38615054
24CDK71.33072214
25NEK21.30281167
26MELK1.28928298
27MAPK151.27228457
28TLK11.20248410
29AURKA1.19742489
30MAP3K71.17264849
31ZAK1.10879754
32SCYL21.08844512
33BUB11.08457673
34MAP3K101.08384829
35TYRO31.06974448
36MAP3K41.06684231
37CAMK1D1.05963020
38DYRK1B1.05264821
39WNK11.04754160
40DMPK1.03471683
41SIK11.02830254
42MAP3K91.00971328
43GRK11.00124266
44MOS0.94090078
45LMTK20.93932920
46PLK40.93295294
47CDK40.92699538
48PDK10.92367551
49PTK20.92128960
50STK30.86529224
51MAP2K70.85974641
52DYRK30.83784467
53BRAF0.82717790
54UHMK10.81098196
55MARK10.78013472
56IRAK10.75893817
57CCNB10.67083878
58SRPK10.63376842
59TTK0.61657936
60NTRK20.61014267
61EEF2K0.60561936
62CHEK20.59121325
63PHKG10.59094279
64PHKG20.59094279
65MAPKAPK50.58884170
66EPHA20.57039950
67CSNK1G20.55234028
68IRAK20.52625969
69MINK10.52102239
70RIPK10.52037232
71DAPK20.51798660
72ERBB30.51771961
73VRK10.51384381
74CAMK1G0.49677046
75BMX0.49654428
76PRKCG0.48826443
77TRIM280.47554046
78PDPK10.45018177
79STK38L0.44835984
80SMG10.44751217
81CSNK1G30.43352745
82PRKACB0.42537012
83BRSK20.41995490
84CAMKK10.41061177
85PAK60.40486208
86RPS6KA20.38152077
87CDK10.38036414
88CHEK10.37825767
89CDK20.37680239
90FGFR10.36643479
91ABL20.36528369
92MAP3K60.36480862
93MAP2K40.36399493
94EPHA40.34953943
95STK110.34839399
96CDK190.34422239
97PASK0.34106106
98NTRK30.33819646
99YES10.33332276
100MAP2K60.33287880
101PLK20.33039844
102RPS6KA10.32071419
103CDK150.31052587
104CSF1R0.30863249
105PRKCI0.30811325
106BMPR1B0.30687743
107CSNK1G10.30651453
108GRK50.30114416
109CDK180.28466684
110CDK140.28027217
111WEE10.27206596
112CAMK10.27132078
113CDC70.26700193
114PLK30.26345706
115PRKAA10.26124881
116STK160.26056909
117AKT20.25836721
118CAMK2A0.25785724
119CDK11A0.25663598
120MAP2K20.24775741
121AKT30.23939403
122AURKB0.23355668
123NEK60.23329354
124MARK20.23118285
125GSK3B0.20986765
126ATR0.20742315
127PKN10.20332247
128PAK10.20115454
129NTRK10.19973638
130DYRK1A0.19393789
131RIPK40.19187775
132MTOR0.19146172
133OXSR10.18687416
134MAP3K80.18263749
135FER0.18245032
136CDK50.17993261
137CDK120.17702786
138ATM0.16765367
139CSNK1D0.16687497
140TESK20.16369067
141CLK10.15799882
142PLK10.15135367
143PRKCZ0.14143234
144WNK30.13270878
145PINK10.13206898
146MAPK130.12749923
147MAP3K20.12442093
148PDGFRB0.12308713
149EGFR0.11765112
150PAK20.11287013
151ARAF0.08692797
152CDK30.08410130
153PAK30.08331690
154PRKG10.08245194
155MAPK100.08177978
156CAMK2D0.08013198

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.41074700
2Pyruvate metabolism_Homo sapiens_hsa006203.26608137
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.14494108
4Vitamin B6 metabolism_Homo sapiens_hsa007503.00964221
5Dorso-ventral axis formation_Homo sapiens_hsa043202.80539551
6Olfactory transduction_Homo sapiens_hsa047402.79622979
7Fatty acid biosynthesis_Homo sapiens_hsa000612.68491251
8Sulfur relay system_Homo sapiens_hsa041222.55770989
9Amphetamine addiction_Homo sapiens_hsa050312.48250887
10Glucagon signaling pathway_Homo sapiens_hsa049222.48233228
11Mismatch repair_Homo sapiens_hsa034302.46179241
12Propanoate metabolism_Homo sapiens_hsa006402.17070595
13Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.15735063
14Oocyte meiosis_Homo sapiens_hsa041142.12935092
15beta-Alanine metabolism_Homo sapiens_hsa004102.12678441
16Synaptic vesicle cycle_Homo sapiens_hsa047212.08628409
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.07562302
18Basal transcription factors_Homo sapiens_hsa030222.02300951
19Histidine metabolism_Homo sapiens_hsa003402.01833457
20Lysine degradation_Homo sapiens_hsa003102.00476839
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.97657524
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.94520675
23Pentose phosphate pathway_Homo sapiens_hsa000301.90922666
24Phototransduction_Homo sapiens_hsa047441.88582089
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82426274
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.81894068
27Arginine and proline metabolism_Homo sapiens_hsa003301.80721998
28Butanoate metabolism_Homo sapiens_hsa006501.79756532
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.75029871
30Huntingtons disease_Homo sapiens_hsa050161.73548149
31Linoleic acid metabolism_Homo sapiens_hsa005911.67397013
32Nucleotide excision repair_Homo sapiens_hsa034201.63939310
33Homologous recombination_Homo sapiens_hsa034401.63450000
34Carbohydrate digestion and absorption_Homo sapiens_hsa049731.62830576
35Glycerolipid metabolism_Homo sapiens_hsa005611.60833202
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.60724485
37Cell cycle_Homo sapiens_hsa041101.56090951
38Selenocompound metabolism_Homo sapiens_hsa004501.51342957
39Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.47258023
40Base excision repair_Homo sapiens_hsa034101.47172310
41Long-term potentiation_Homo sapiens_hsa047201.45225149
42Insulin secretion_Homo sapiens_hsa049111.41731259
43DNA replication_Homo sapiens_hsa030301.41689828
44Fanconi anemia pathway_Homo sapiens_hsa034601.39624223
45Renin secretion_Homo sapiens_hsa049241.39413860
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36218050
47Glycerophospholipid metabolism_Homo sapiens_hsa005641.34898369
48Proteasome_Homo sapiens_hsa030501.33901103
49Basal cell carcinoma_Homo sapiens_hsa052171.32071371
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.30653817
51Cardiac muscle contraction_Homo sapiens_hsa042601.29847499
52Circadian entrainment_Homo sapiens_hsa047131.29598349
53Taste transduction_Homo sapiens_hsa047421.29288322
54Glycosaminoglycan degradation_Homo sapiens_hsa005311.28902170
55Cocaine addiction_Homo sapiens_hsa050301.26008512
56Dopaminergic synapse_Homo sapiens_hsa047281.24229881
57Collecting duct acid secretion_Homo sapiens_hsa049661.21471052
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.18054189
59Pentose and glucuronate interconversions_Homo sapiens_hsa000401.16460344
60Calcium signaling pathway_Homo sapiens_hsa040201.14412030
61PPAR signaling pathway_Homo sapiens_hsa033201.13726300
62Tryptophan metabolism_Homo sapiens_hsa003801.12875117
63Gastric acid secretion_Homo sapiens_hsa049711.12359272
64Estrogen signaling pathway_Homo sapiens_hsa049151.08619386
65mRNA surveillance pathway_Homo sapiens_hsa030151.08487455
66Phenylalanine metabolism_Homo sapiens_hsa003601.08017231
67Nicotine addiction_Homo sapiens_hsa050331.07259579
68Cysteine and methionine metabolism_Homo sapiens_hsa002701.07012124
69Salivary secretion_Homo sapiens_hsa049701.05415263
70Glutamatergic synapse_Homo sapiens_hsa047241.04906987
71RNA polymerase_Homo sapiens_hsa030201.04156049
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.02842421
73Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00385789
74Mineral absorption_Homo sapiens_hsa049780.98622149
75Ether lipid metabolism_Homo sapiens_hsa005650.95713823
76Peroxisome_Homo sapiens_hsa041460.89888724
77Carbon metabolism_Homo sapiens_hsa012000.88403655
78Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.87357856
79Hedgehog signaling pathway_Homo sapiens_hsa043400.85724229
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85450947
81Morphine addiction_Homo sapiens_hsa050320.85025079
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.81590023
83cAMP signaling pathway_Homo sapiens_hsa040240.80767890
84Thyroid hormone synthesis_Homo sapiens_hsa049180.79966219
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76695615
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75091766
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74298017
88Parkinsons disease_Homo sapiens_hsa050120.72455626
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71101400
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69981488
91Bile secretion_Homo sapiens_hsa049760.69872243
92Purine metabolism_Homo sapiens_hsa002300.69610864
93Inositol phosphate metabolism_Homo sapiens_hsa005620.68945374
94Alcoholism_Homo sapiens_hsa050340.66971749
95Fructose and mannose metabolism_Homo sapiens_hsa000510.66249912
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65162908
97Adherens junction_Homo sapiens_hsa045200.64554783
98Arginine biosynthesis_Homo sapiens_hsa002200.63034729
99Wnt signaling pathway_Homo sapiens_hsa043100.62787719
100Steroid biosynthesis_Homo sapiens_hsa001000.62446437
101Oxidative phosphorylation_Homo sapiens_hsa001900.60533500
102Endocytosis_Homo sapiens_hsa041440.58700247
103Cholinergic synapse_Homo sapiens_hsa047250.58123506
104Fat digestion and absorption_Homo sapiens_hsa049750.58083893
105TGF-beta signaling pathway_Homo sapiens_hsa043500.57656432
106Biosynthesis of amino acids_Homo sapiens_hsa012300.56903609
107Viral myocarditis_Homo sapiens_hsa054160.56814894
108ABC transporters_Homo sapiens_hsa020100.56802396
109Pyrimidine metabolism_Homo sapiens_hsa002400.55594074
110Hippo signaling pathway_Homo sapiens_hsa043900.54192891
111N-Glycan biosynthesis_Homo sapiens_hsa005100.53966561
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53952600
113RNA transport_Homo sapiens_hsa030130.52362001
114AMPK signaling pathway_Homo sapiens_hsa041520.51457295
115Oxytocin signaling pathway_Homo sapiens_hsa049210.49677255
116Colorectal cancer_Homo sapiens_hsa052100.49170744
117Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47158691
118Pancreatic secretion_Homo sapiens_hsa049720.45670824
119Metabolic pathways_Homo sapiens_hsa011000.45604859
120Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44120045
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.43894791
122Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42795871
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.42694527
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42319473
125Spliceosome_Homo sapiens_hsa030400.42010650
126GABAergic synapse_Homo sapiens_hsa047270.41290467
127Proteoglycans in cancer_Homo sapiens_hsa052050.40659775
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39870791
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39226351
130Fatty acid metabolism_Homo sapiens_hsa012120.38813630
131p53 signaling pathway_Homo sapiens_hsa041150.38729393
132Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37342088
133VEGF signaling pathway_Homo sapiens_hsa043700.36498098
134Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36043505
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35658036
136Sphingolipid metabolism_Homo sapiens_hsa006000.35470607
137Alzheimers disease_Homo sapiens_hsa050100.35368613
138Central carbon metabolism in cancer_Homo sapiens_hsa052300.35308967
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34478243
140Tight junction_Homo sapiens_hsa045300.34450101
141Focal adhesion_Homo sapiens_hsa045100.33813496
142Axon guidance_Homo sapiens_hsa043600.33704472
143Dilated cardiomyopathy_Homo sapiens_hsa054140.33543377
144Melanogenesis_Homo sapiens_hsa049160.33522816
145Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.32608838
146Renin-angiotensin system_Homo sapiens_hsa046140.32060810
147Serotonergic synapse_Homo sapiens_hsa047260.31192393
148Type II diabetes mellitus_Homo sapiens_hsa049300.31034252
149Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30796008
150Ovarian steroidogenesis_Homo sapiens_hsa049130.29952299
151Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29805983
152Viral carcinogenesis_Homo sapiens_hsa052030.28813579
153Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28635847
154Vibrio cholerae infection_Homo sapiens_hsa051100.27304197
155Folate biosynthesis_Homo sapiens_hsa007900.26864830
156Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26315080
157Protein digestion and absorption_Homo sapiens_hsa049740.25965962
158Gap junction_Homo sapiens_hsa045400.25564248
159Fatty acid degradation_Homo sapiens_hsa000710.25190339

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