CCDC88B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the hook-related protein family. Members of this family are characterized by an N-terminal potential microtubule binding domain, a central coiled-coiled and a C-terminal Hook-related domain. The encoded protein may be involved in linking organelles to microtubules. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.30013294
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.99761245
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.99761245
4antigen processing and presentation of endogenous antigen (GO:0019883)5.50129842
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.29224155
6negative regulation of cell killing (GO:0031342)5.29224155
7detection of bacterium (GO:0016045)4.90561872
8detection of other organism (GO:0098543)4.90282650
9regulation of gamma-delta T cell differentiation (GO:0045586)4.79307503
10leukocyte aggregation (GO:0070486)4.77815180
11regulation of gamma-delta T cell activation (GO:0046643)4.70765709
12positive thymic T cell selection (GO:0045059)4.38941071
13regulation of B cell receptor signaling pathway (GO:0050855)4.21468391
14NIK/NF-kappaB signaling (GO:0038061)4.20350347
15negative regulation of lymphocyte mediated immunity (GO:0002707)4.18259011
16modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.16770318
17positive regulation by organism of defense response of other organism involved in symbiotic interact4.16770318
18modulation by symbiont of host immune response (GO:0052553)4.16770318
19positive regulation by symbiont of host defense response (GO:0052509)4.16770318
20modulation by symbiont of host defense response (GO:0052031)4.16770318
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.16770318
22negative thymic T cell selection (GO:0045060)4.16349272
23negative T cell selection (GO:0043383)4.14001447
24positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.11329509
25regulation of interleukin-12 biosynthetic process (GO:0045075)4.09199911
26response to muramyl dipeptide (GO:0032495)3.98662841
27positive regulation of B cell differentiation (GO:0045579)3.95746805
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.94349040
29T cell migration (GO:0072678)3.89369997
30tolerance induction (GO:0002507)3.89020178
31negative regulation of T cell mediated immunity (GO:0002710)3.84918773
32detection of external biotic stimulus (GO:0098581)3.84552046
33positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.78841148
34negative regulation of interleukin-12 production (GO:0032695)3.77098616
35negative regulation of leukocyte mediated immunity (GO:0002704)3.73479776
36regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.70555325
37thymic T cell selection (GO:0045061)3.68983787
38regulation of B cell differentiation (GO:0045577)3.68013093
39cellular extravasation (GO:0045123)3.64938145
40positive T cell selection (GO:0043368)3.62515494
41response to interleukin-15 (GO:0070672)3.61039848
42response to peptidoglycan (GO:0032494)3.56680006
43interferon-gamma production (GO:0032609)3.50586062
44T cell selection (GO:0045058)3.46989966
45regulation of mast cell degranulation (GO:0043304)3.42947028
46leukocyte migration involved in inflammatory response (GO:0002523)3.41768546
47JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.41196685
48negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.40112107
49detection of biotic stimulus (GO:0009595)3.39040135
50microglial cell activation (GO:0001774)3.35508383
51respiratory burst (GO:0045730)3.33753564
52regulation of T cell tolerance induction (GO:0002664)3.31882251
53antigen processing and presentation via MHC class Ib (GO:0002475)3.31330754
54B cell receptor signaling pathway (GO:0050853)3.30403107
55leukocyte cell-cell adhesion (GO:0007159)3.28603226
56regulation of dendritic cell antigen processing and presentation (GO:0002604)3.27345319
57myeloid dendritic cell activation (GO:0001773)3.26730403
58regulation of interleukin-2 biosynthetic process (GO:0045076)3.24170877
59neutrophil activation involved in immune response (GO:0002283)3.22908871
60myeloid dendritic cell differentiation (GO:0043011)3.21160187
61regulation of myeloid leukocyte mediated immunity (GO:0002886)3.19912521
62regulation of tolerance induction (GO:0002643)3.19517177
63positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.18753913
64immunoglobulin mediated immune response (GO:0016064)3.17981688
65positive regulation of antigen processing and presentation (GO:0002579)3.17856254
66activated T cell proliferation (GO:0050798)3.16538988
67regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.15094607
68regulation of mast cell activation involved in immune response (GO:0033006)3.14768756
69leukocyte degranulation (GO:0043299)3.14670854
70positive regulation of mast cell activation (GO:0033005)3.08882513
71detection of molecule of bacterial origin (GO:0032490)3.07990205
72Arp2/3 complex-mediated actin nucleation (GO:0034314)3.06383986
73macrophage activation (GO:0042116)3.06254513
74regulation of mast cell activation (GO:0033003)3.06186872
75B cell mediated immunity (GO:0019724)3.05388711
76regulation of T cell mediated cytotoxicity (GO:0001914)3.05276353
77response to type I interferon (GO:0034340)3.05237913
78regulation of interferon-beta biosynthetic process (GO:0045357)3.05229263
79positive regulation of interleukin-2 production (GO:0032743)3.04908256
80regulation of type I interferon-mediated signaling pathway (GO:0060338)3.04861913
81negative regulation of innate immune response (GO:0045824)3.04720470
82regulation of leukocyte degranulation (GO:0043300)3.03811169
83regulation of natural killer cell mediated immunity (GO:0002715)3.03587991
84regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.03587991
85positive regulation of granulocyte differentiation (GO:0030854)3.03200988
86T cell homeostasis (GO:0043029)3.02998796
87regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.02596604
88production of molecular mediator involved in inflammatory response (GO:0002532)3.01161511
89macrophage activation involved in immune response (GO:0002281)3.00724743
90negative regulation of interleukin-6 production (GO:0032715)3.00590133
91cellular response to type I interferon (GO:0071357)2.99487852
92type I interferon signaling pathway (GO:0060337)2.99487852
93T cell receptor signaling pathway (GO:0050852)2.98203235
94positive regulation of isotype switching (GO:0045830)2.98177226
95positive regulation of humoral immune response (GO:0002922)2.97581146
96antigen receptor-mediated signaling pathway (GO:0050851)2.97004199
97negative regulation of phagocytosis (GO:0050765)2.96886009
98interferon-gamma-mediated signaling pathway (GO:0060333)2.96325003
99negative regulation of alpha-beta T cell activation (GO:0046636)2.95961569
100mature B cell differentiation (GO:0002335)2.93024538
101negative regulation of T-helper cell differentiation (GO:0045623)2.92489203
102response to protozoan (GO:0001562)2.92336021
103neutrophil activation (GO:0042119)2.92027671
104regulation of alpha-beta T cell proliferation (GO:0046640)2.91996179
105lymphocyte homeostasis (GO:0002260)2.90573773
106cellular response to interleukin-15 (GO:0071350)2.89336208
107myeloid cell activation involved in immune response (GO:0002275)2.87705924
108positive regulation of interferon-alpha production (GO:0032727)2.84052254
109defense response to protozoan (GO:0042832)2.83643826
110T cell proliferation (GO:0042098)2.83417154
111regulation of response to interferon-gamma (GO:0060330)2.79946139
112response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.79825158
113response to host immune response (GO:0052572)2.79825158
114granulocyte activation (GO:0036230)2.79606686
115germinal center formation (GO:0002467)2.79509638
116mast cell activation (GO:0045576)2.78367745
117positive regulation of immunoglobulin mediated immune response (GO:0002891)2.78151067
118positive regulation of B cell mediated immunity (GO:0002714)2.78151067
119T cell costimulation (GO:0031295)2.77445707
120B cell homeostasis (GO:0001782)2.77393393
121negative regulation of erythrocyte differentiation (GO:0045647)2.76453160
122natural killer cell differentiation (GO:0001779)2.75984681
123regulation of interferon-alpha production (GO:0032647)2.75371474
124response to fungus (GO:0009620)2.73978075
125response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.73132549
126response to host (GO:0075136)2.73132549
127response to host defenses (GO:0052200)2.73132549
128lymphocyte costimulation (GO:0031294)2.71888107
129positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.71829733
130regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.70741472
131modulation by symbiont of host cellular process (GO:0044068)2.70413817
132regulation of antigen processing and presentation (GO:0002577)2.68550164
133neutrophil mediated immunity (GO:0002446)2.67782699

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.32620858
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.27127160
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.23657801
4E2F7_22180533_ChIP-Seq_HELA_Human3.95478956
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.78803630
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.76599834
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.50885505
8MYC_22102868_ChIP-Seq_BL_Human3.38261078
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.29713059
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.20359945
11VDR_21846776_ChIP-Seq_THP-1_Human3.10156257
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.01345951
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.93915885
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.91664915
15* IRF8_27001747_Chip-Seq_BMDM_Mouse2.91207812
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.85207901
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.83810113
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.80346532
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.66624889
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.62740408
21SCL_19346495_ChIP-Seq_HPC-7_Human2.60479436
22MYB_26560356_Chip-Seq_TH2_Human2.57228915
23MAF_26560356_Chip-Seq_TH1_Human2.56379012
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.51962118
25RUNX_20019798_ChIP-Seq_JUKART_Human2.45860338
26VDR_24763502_ChIP-Seq_THP-1_Human2.35157298
27MYB_26560356_Chip-Seq_TH1_Human2.32609479
28BRD4_27068464_Chip-Seq_AML-cells_Mouse2.32332462
29TCF7_22412390_ChIP-Seq_EML_Mouse2.30602845
30* SPI1_23547873_ChIP-Seq_NB4_Human2.28303363
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.27149608
32UTX_26944678_Chip-Seq_JUKART_Human2.26882384
33RUNX1_22412390_ChIP-Seq_EML_Mouse2.16831179
34* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.10211873
35* ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.07485484
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.03066949
37SPI1_23127762_ChIP-Seq_K562_Human1.89474038
38* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.88642581
39FOXM1_23109430_ChIP-Seq_U2OS_Human1.85094550
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.84412447
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.80781445
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.80569342
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.77723562
44KDM2B_26808549_Chip-Seq_DND41_Human1.72502105
45* MAF_26560356_Chip-Seq_TH2_Human1.70168032
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.66313763
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.60974875
48GATA3_27048872_Chip-Seq_THYMUS_Human1.59596352
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.58040497
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.51861118
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.51507086
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.48890847
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48709420
54PU_27001747_Chip-Seq_BMDM_Mouse1.48324193
55PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.45861188
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44544996
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43623549
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.42488978
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.42392958
60TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32487173
61BCL6_27268052_Chip-Seq_Bcells_Human1.30691915
62CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29919960
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.28868039
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28713039
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.27995510
66BCOR_27268052_Chip-Seq_Bcells_Human1.24166818
67CIITA_25753668_ChIP-Seq_RAJI_Human1.23684951
68EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.23518972
69CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20733790
70NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.18480265
71VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.17611461
72GATA1_19941827_ChIP-Seq_MEL_Mouse1.13417804
73GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12981471
74STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11013097
75* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10153354
76GATA3_26560356_Chip-Seq_TH2_Human1.09161368
77TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08975409
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.05654222
79* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05190905
80PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02271034
81GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02178274
82ELF1_20517297_ChIP-Seq_JURKAT_Human1.01158464
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00722308
84ELF1_17652178_ChIP-ChIP_JURKAT_Human1.00204599
85CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.00030622
86SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99666943
87KDM2B_26808549_Chip-Seq_JURKAT_Human0.99122506
88SA1_27219007_Chip-Seq_ERYTHROID_Human0.98374589
89* NCOR1_26117541_ChIP-Seq_K562_Human0.98353094
90CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96428404
91GATA1_22025678_ChIP-Seq_K562_Human0.96317093
92P68_20966046_ChIP-Seq_HELA_Human0.95514908
93LXR_22292898_ChIP-Seq_THP-1_Human0.94592549
94ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94508870
95VDR_24787735_ChIP-Seq_THP-1_Human0.94118438
96CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93214249
97E2F4_17652178_ChIP-ChIP_JURKAT_Human0.91877526
98LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90997709
99PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89720489
100TFEB_21752829_ChIP-Seq_HELA_Human0.87835374
101PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84215252
102RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81825540
103HOXB4_20404135_ChIP-ChIP_EML_Mouse0.80618110
104KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.80431842
105STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.80107695
106* GATA1_19941826_ChIP-Seq_K562_Human0.79962057
107* GATA2_19941826_ChIP-Seq_K562_Human0.79231771
108RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.78548281
109PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76601699
110GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76448050
111* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73621185
112SPI1_20517297_ChIP-Seq_HL60_Human0.73042853
113ETS1_22383799_ChIP-Seq_G1ME_Mouse0.72833172

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.74366342
2MP0003303_peritoneal_inflammation3.67043464
3MP0000685_abnormal_immune_system3.28115349
4MP0003436_decreased_susceptibility_to3.27888758
5MP0005671_abnormal_response_to3.05521548
6MP0001800_abnormal_humoral_immune3.00684377
7MP0005387_immune_system_phenotype2.97573927
8MP0001790_abnormal_immune_system2.97573927
9MP0003763_abnormal_thymus_physiology2.88062759
10MP0005000_abnormal_immune_tolerance2.83889787
11MP0009785_altered_susceptibility_to2.80729722
12MP0002452_abnormal_antigen_presenting2.69931063
13MP0002723_abnormal_immune_serum2.66007918
14MP0005025_abnormal_response_to2.61921792
15MP0002419_abnormal_innate_immunity2.61239087
16MP0002420_abnormal_adaptive_immunity2.56413506
17MP0001819_abnormal_immune_cell2.55579743
18MP0003300_gastrointestinal_ulcer2.52554099
19MP0004510_myositis2.38544138
20MP0002398_abnormal_bone_marrow2.37680265
21MP0006082_CNS_inflammation2.37629511
22MP0009278_abnormal_bone_marrow2.33803581
23MP0005464_abnormal_platelet_physiology2.32784122
24MP0002405_respiratory_system_inflammati2.31511011
25MP0002396_abnormal_hematopoietic_system2.30963889
26MP0002148_abnormal_hypersensitivity_rea2.18197956
27MP0000716_abnormal_immune_system2.14469277
28MP0001873_stomach_inflammation2.10563548
29MP0002166_altered_tumor_susceptibility2.10230140
30MP0004947_skin_inflammation2.06724328
31MP0009333_abnormal_splenocyte_physiolog2.01399503
32MP0010155_abnormal_intestine_physiology1.98329723
33MP0000689_abnormal_spleen_morphology1.97067222
34MP0004808_abnormal_hematopoietic_stem1.95586927
35MP0002722_abnormal_immune_system1.94910879
36MP0005397_hematopoietic_system_phenotyp1.91598595
37MP0001545_abnormal_hematopoietic_system1.91598595
38MP0001853_heart_inflammation1.81248241
39MP0003724_increased_susceptibility_to1.81102426
40MP0002429_abnormal_blood_cell1.80001480
41MP0001845_abnormal_inflammatory_respons1.79782394
42MP0002006_tumorigenesis1.78985724
43MP0000703_abnormal_thymus_morphology1.76981108
44MP0003172_abnormal_lysosome_physiology1.71025189
45MP0005058_abnormal_lysosome_morphology1.67987604
46MP0000465_gastrointestinal_hemorrhage1.60729941
47MP0001533_abnormal_skeleton_physiology1.59060674
48MP0003866_abnormal_defecation1.58587532
49MP0008260_abnormal_autophagy1.57238885
50MP0002132_abnormal_respiratory_system1.55985731
51MP0004381_abnormal_hair_follicle1.47167437
52MP0000569_abnormal_digit_pigmentation1.47065595
53MP0005174_abnormal_tail_pigmentation1.46970453
54MP0005310_abnormal_salivary_gland1.46676586
55MP0010307_abnormal_tumor_latency1.39395285
56MP0003183_abnormal_peptide_metabolism1.36860337
57MP0008469_abnormal_protein_level1.35994463
58MP0003448_altered_tumor_morphology1.34521660
59MP0002933_joint_inflammation1.31807940
60MP0005076_abnormal_cell_differentiation1.30172309
61MP0001986_abnormal_taste_sensitivity1.26915497
62MP0001851_eye_inflammation1.26605129
63MP0000490_abnormal_crypts_of1.24056701
64MP0010352_gastrointestinal_tract_polyps1.23915772
65MP0000858_altered_metastatic_potential1.22801041
66MP0005451_abnormal_body_composition1.19981686
67MP0009840_abnormal_foam_cell1.17669867
68MP0003191_abnormal_cellular_cholesterol1.17222145
69MP0002277_abnormal_respiratory_mucosa1.06870306
70MP0004883_abnormal_blood_vessel1.02071485
71MP0002998_abnormal_bone_remodeling0.96677643
72MP0000343_altered_response_to0.96004156
73MP0009764_decreased_sensitivity_to0.89420059
74MP0002009_preneoplasia0.88673602
75MP0002019_abnormal_tumor_incidence0.88265356
76MP0000015_abnormal_ear_pigmentation0.87070053
77MP0003566_abnormal_cell_adhesion0.86761868
78MP0000604_amyloidosis0.85237771
79MP0002138_abnormal_hepatobiliary_system0.84403290
80MP0003690_abnormal_glial_cell0.80296606
81MP0005023_abnormal_wound_healing0.77672724
82MP0003075_altered_response_to0.77477866
83MP0009763_increased_sensitivity_to0.76358263
84MP0003693_abnormal_embryo_hatching0.76007619
85MP0008961_abnormal_basal_metabolism0.75264673
86MP0008057_abnormal_DNA_replication0.73658337
87MP0001663_abnormal_digestive_system0.72137289
88MP0005075_abnormal_melanosome_morpholog0.71269444
89MP0003453_abnormal_keratinocyte_physiol0.70727504
90MP0000371_diluted_coat_color0.67393730
91MP0005166_decreased_susceptibility_to0.66510282
92MP0003077_abnormal_cell_cycle0.65812080
93MP0003828_pulmonary_edema0.63802362
94MP0005164_abnormal_response_to0.63549568
95MP0003091_abnormal_cell_migration0.61629591
96MP0002693_abnormal_pancreas_physiology0.61565310
97MP0005390_skeleton_phenotype0.61089119
98MP0008874_decreased_physiological_sensi0.59458685
99MP0003795_abnormal_bone_structure0.59320886
100MP0000313_abnormal_cell_death0.58730794
101MP0000249_abnormal_blood_vessel0.57939741
102MP0008004_abnormal_stomach_pH0.57926140
103MP0005381_digestive/alimentary_phenotyp0.57402423
104MP0000609_abnormal_liver_physiology0.55182652
105MP0008873_increased_physiological_sensi0.54242692
106MP0003045_fibrosis0.54171184
107MP0010094_abnormal_chromosome_stability0.52941020
108MP0003656_abnormal_erythrocyte_physiolo0.52053255
109MP0009765_abnormal_xenobiotic_induced0.50683532
110MP0002928_abnormal_bile_duct0.50485101
111MP0004130_abnormal_muscle_cell0.50296825
112MP0002877_abnormal_melanocyte_morpholog0.50064523
113MP0005621_abnormal_cell_physiology0.50009870
114MP0002136_abnormal_kidney_physiology0.49836316
115MP0002095_abnormal_skin_pigmentation0.48157620
116MP0005535_abnormal_body_temperature0.46804604
117MP0000470_abnormal_stomach_morphology0.44239368
118MP0001348_abnormal_lacrimal_gland0.41423270
119MP0002133_abnormal_respiratory_system0.40543050

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.02230823
2Recurrent abscess formation (HP:0002722)5.49626926
3Recurrent bacterial skin infections (HP:0005406)4.95949297
4Recurrent fungal infections (HP:0002841)4.81642918
5Elevated erythrocyte sedimentation rate (HP:0003565)4.63045960
6Recurrent viral infections (HP:0004429)4.45292008
7Chronic otitis media (HP:0000389)4.37048372
8Myositis (HP:0100614)4.21836455
9Stomatitis (HP:0010280)4.06860375
10Abnormal delayed hypersensitivity skin test (HP:0002963)3.98865782
11Mediastinal lymphadenopathy (HP:0100721)3.98065894
12Nasal polyposis (HP:0100582)3.89807494
13Recurrent gram-negative bacterial infections (HP:0005420)3.76230637
14Recurrent cutaneous fungal infections (HP:0011370)3.75388138
15Chronic mucocutaneous candidiasis (HP:0002728)3.75388138
16IgM deficiency (HP:0002850)3.72626924
17Recurrent skin infections (HP:0001581)3.72184891
18T lymphocytopenia (HP:0005403)3.61419242
19Panhypogammaglobulinemia (HP:0003139)3.57358058
20Abnormality of T cell number (HP:0011839)3.55278641
21Obstructive lung disease (HP:0006536)3.53435224
22Chronic obstructive pulmonary disease (HP:0006510)3.53435224
23Abnormality of macrophages (HP:0004311)3.52072989
24Autoimmune thrombocytopenia (HP:0001973)3.44637803
25Pustule (HP:0200039)3.43775408
26Abnormality of the nasal mucosa (HP:0000433)3.43148357
27Meningitis (HP:0001287)3.43106830
28Hypochromic anemia (HP:0001931)3.38682687
29Hypochromic microcytic anemia (HP:0004840)3.36496744
30Inflammation of the large intestine (HP:0002037)3.32006543
31Recurrent bronchitis (HP:0002837)3.27818482
32Abnormality of T cells (HP:0002843)3.26804575
33Orchitis (HP:0100796)3.26074821
34Gastrointestinal inflammation (HP:0004386)3.25563709
35Cellulitis (HP:0100658)3.23770100
36Retrobulbar optic neuritis (HP:0100654)3.22651714
37Optic neuritis (HP:0100653)3.22651714
38Vasculitis (HP:0002633)3.21364893
39Abnormality of the fingertips (HP:0001211)3.09451861
40Colitis (HP:0002583)3.00507880
41Leukocytosis (HP:0001974)2.98523407
42Increased IgE level (HP:0003212)2.94765775
43Gingivitis (HP:0000230)2.94713355
44Spontaneous hematomas (HP:0007420)2.92066590
45Thrombocytosis (HP:0001894)2.91776387
46Abnormality of T cell physiology (HP:0011840)2.89759307
47Eosinophilia (HP:0001880)2.83913660
48Arterial thrombosis (HP:0004420)2.82020484
49Prolonged bleeding time (HP:0003010)2.79167890
50Periodontitis (HP:0000704)2.64876809
51Pulmonary infiltrates (HP:0002113)2.63484018
52Hemoptysis (HP:0002105)2.61239216
53Recurrent sinusitis (HP:0011108)2.60162279
54Increased IgM level (HP:0003496)2.60091379
55Chest pain (HP:0100749)2.59633263
56Episodic fever (HP:0001954)2.58462457
57Abnormality of B cell number (HP:0010975)2.57616098
58B lymphocytopenia (HP:0010976)2.57616098
59Epistaxis (HP:0000421)2.57526439
60Granulocytopenia (HP:0001913)2.56676727
61Petechiae (HP:0000967)2.54495041
62Gingival bleeding (HP:0000225)2.54008404
63Interstitial pulmonary disease (HP:0006530)2.52944846
64Gastrointestinal infarctions (HP:0005244)2.45877478
65Lymphopenia (HP:0001888)2.45654157
66Abnormality of cells of the lymphoid lineage (HP:0012140)2.44863874
67Microcytic anemia (HP:0001935)2.43863343
68Severe combined immunodeficiency (HP:0004430)2.42620270
69Thyroiditis (HP:0100646)2.41654451
70Abnormality of eosinophils (HP:0001879)2.41227021
71Increased density of long bones (HP:0006392)2.40648824
72Hematochezia (HP:0002573)2.40564468
73Anorexia (HP:0002039)2.39638614
74Osteomyelitis (HP:0002754)2.38766611
75Sepsis (HP:0100806)2.36225188
76Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.35373004
77Abnormal platelet function (HP:0011869)2.34610590
78Impaired platelet aggregation (HP:0003540)2.34610590
79Combined immunodeficiency (HP:0005387)2.33021663
80Agammaglobulinemia (HP:0004432)2.32256038
81Abnormality of the pleura (HP:0002103)2.30441100
82Increased cerebral lipofuscin (HP:0011813)2.30026848
83Encephalitis (HP:0002383)2.27063767
84Urticaria (HP:0001025)2.24297690
85Cheilitis (HP:0100825)2.22971652
86Papilledema (HP:0001085)2.20744751
87Vacuolated lymphocytes (HP:0001922)2.20321364
88Viral hepatitis (HP:0006562)2.19399117
89Papilloma (HP:0012740)2.19270589
90Verrucae (HP:0200043)2.19270589
91Chronic sinusitis (HP:0011109)2.15513845
92Chronic diarrhea (HP:0002028)2.12658727
93Keratoconjunctivitis sicca (HP:0001097)2.12612877
94Systemic lupus erythematosus (HP:0002725)2.11086229
95Premature loss of primary teeth (HP:0006323)2.10290329
96IgA deficiency (HP:0002720)2.09738711
97Abnormal platelet volume (HP:0011876)2.09318329
98Joint swelling (HP:0001386)2.09238930
99Hypergammaglobulinemia (HP:0010702)2.08476813
100Skin ulcer (HP:0200042)2.07768991
101Recurrent pneumonia (HP:0006532)2.06296574
102Fatigue (HP:0012378)2.04343886
103Gangrene (HP:0100758)2.04139335
104IgG deficiency (HP:0004315)2.03358085
105Recurrent lower respiratory tract infections (HP:0002783)2.03329075
106Increased neuronal autofluorescent lipopigment (HP:0002074)2.02655160
107Skin rash (HP:0000988)2.01661752
108Keratoconjunctivitis (HP:0001096)2.01153212
109Emphysema (HP:0002097)1.98648122
110Lymphoma (HP:0002665)1.92477455
111Myocardial infarction (HP:0001658)1.92293938
112Pulmonary embolism (HP:0002204)1.91790306
113Slow saccadic eye movements (HP:0000514)1.91742160
114Amyloidosis (HP:0011034)1.91496212
115Glomerulopathy (HP:0100820)1.91488112
116Autoimmune hemolytic anemia (HP:0001890)1.91050806
117Arthralgia (HP:0002829)1.89753056
118Restrictive lung disease (HP:0002091)1.89569711
119Abnormality of the endocardium (HP:0004306)1.88976526
120Increased serum ferritin (HP:0003281)1.88817845
121Thoracic kyphosis (HP:0002942)1.88451490
122Abnormality of the heme biosynthetic pathway (HP:0010472)1.88135628
123Gastrointestinal stroma tumor (HP:0100723)1.87479053
124Acute myeloid leukemia (HP:0004808)1.87447138
125Purpura (HP:0000979)1.86486007

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.00750193
2TXK3.00445631
3PRPF4B2.99591411
4TYK22.91704825
5JAK32.81894760
6MAP3K142.74898872
7EEF2K2.60672919
8ZAP702.45582726
9IRAK42.44921924
10BLK2.28046894
11TBK12.25916266
12IKBKE2.22684001
13STK102.07359536
14MAP3K102.03690402
15RIPK41.98644646
16IRAK31.92881892
17PKN21.84655618
18KIT1.84487325
19BTK1.81491826
20JAK11.81178436
21GRK61.78810884
22TRIB31.77284530
23EPHB11.76267316
24ITK1.76157471
25FES1.71623703
26MAP3K131.71075433
27IKBKB1.66171039
28CSF1R1.65765837
29SIK21.62179823
30SYK1.58927553
31HCK1.57553681
32CSK1.55907399
33LCK1.47050666
34TEC1.43958373
35ERN11.42106216
36MAP2K31.40897661
37FGFR41.40813981
38TGFBR21.38273112
39TAOK31.36189701
40CDK121.29715404
41CHUK1.20858051
42RPS6KA41.20177284
43PIM11.16267958
44CLK11.13129026
45FGFR31.13039154
46LRRK21.11942842
47JAK21.09656294
48PTK61.07944626
49MAP3K11.06479432
50MARK31.00936715
51SMG11.00148465
52PRKD20.95757884
53LYN0.91752923
54TTN0.86795170
55FLT30.85290564
56MAPK120.84320260
57KSR20.82951928
58NEK20.82620105
59CDC42BPA0.82019152
60ALK0.81408690
61BMPR20.81146961
62TAOK10.80024593
63CDK40.77877946
64YES10.77437762
65MAP3K70.74581004
66MAPK70.71878904
67NME20.69938195
68PDPK10.69411862
69MAP3K110.69348694
70NLK0.67558780
71CDK190.66799740
72CAMKK10.66546012
73TAOK20.65805909
74FGR0.62903619
75TNK20.62698109
76TRPM70.62394463
77IRAK20.62321256
78PRKCQ0.61450392
79MATK0.61034038
80CAMK1D0.60182266
81STK110.59621708
82PIM20.59069549
83CDK60.57460928
84STK40.57307938
85PRKCH0.56473411
86CAMK1G0.53548501
87PDK10.51974707
88PAK40.49840657
89MAP3K80.49720509
90PTK2B0.49569419
91MAP2K20.49234994
92PASK0.47338904
93RPS6KA60.47094418
94MAPKAPK20.46405678
95HIPK20.46043631
96DAPK20.45904998
97SGK30.45203961
98MAP3K30.44983394
99MAPK40.44563588
100SCYL20.43919067
101EPHA30.43567481
102EGFR0.43031466
103MAP2K60.40340418
104PDGFRB0.40086361
105MST40.40066370
106MAP3K60.40053691
107DYRK1B0.38386808
108TESK20.38265460
109RET0.37849586
110ABL10.36979395
111RPS6KC10.35472389
112RPS6KL10.35472389
113SIK30.34252451
114SGK20.33794896
115CAMKK20.33364044
116BRD40.32507904
117PIK3CG0.32090573
118BMX0.31943104
119MAPK110.29617590
120CDK90.28714821
121TSSK60.28471601
122PRKCZ0.28281541
123RPS6KB20.27915631
124RPS6KA10.26348591
125RPS6KA20.25041581
126SIK10.24615294
127MARK20.24384168
128ATR0.24326784
129FYN0.24039555
130IRAK10.22748173

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.00556750
2Leishmaniasis_Homo sapiens_hsa051402.98715911
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.64964200
4Osteoclast differentiation_Homo sapiens_hsa043802.61972047
5B cell receptor signaling pathway_Homo sapiens_hsa046622.48104428
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.42826272
7Measles_Homo sapiens_hsa051622.38411760
8T cell receptor signaling pathway_Homo sapiens_hsa046602.24417172
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.09763409
10Antigen processing and presentation_Homo sapiens_hsa046122.03637394
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.98880588
12NOD-like receptor signaling pathway_Homo sapiens_hsa046211.96845553
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.92120527
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.89477132
15Hematopoietic cell lineage_Homo sapiens_hsa046401.84165411
16Staphylococcus aureus infection_Homo sapiens_hsa051501.84125499
17Allograft rejection_Homo sapiens_hsa053301.82706857
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.81133142
19Graft-versus-host disease_Homo sapiens_hsa053321.79451794
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.74072779
21Toxoplasmosis_Homo sapiens_hsa051451.72980085
22Legionellosis_Homo sapiens_hsa051341.69116754
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.66234906
24Acute myeloid leukemia_Homo sapiens_hsa052211.63694381
25Herpes simplex infection_Homo sapiens_hsa051681.63525589
26Influenza A_Homo sapiens_hsa051641.62016065
27TNF signaling pathway_Homo sapiens_hsa046681.58990368
28Tuberculosis_Homo sapiens_hsa051521.58983107
29Pertussis_Homo sapiens_hsa051331.53178816
30Asthma_Homo sapiens_hsa053101.52073360
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.49929715
32Chemokine signaling pathway_Homo sapiens_hsa040621.49398354
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.46041318
34Chronic myeloid leukemia_Homo sapiens_hsa052201.45132275
35Apoptosis_Homo sapiens_hsa042101.43110634
36Hepatitis B_Homo sapiens_hsa051611.40793688
37Shigellosis_Homo sapiens_hsa051311.40236239
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.32749932
39Malaria_Homo sapiens_hsa051441.31079806
40Viral myocarditis_Homo sapiens_hsa054161.19467982
41Pancreatic cancer_Homo sapiens_hsa052121.15552825
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12997328
43Other glycan degradation_Homo sapiens_hsa005111.12973602
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08808982
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03781409
46Salmonella infection_Homo sapiens_hsa051321.03236512
47Neurotrophin signaling pathway_Homo sapiens_hsa047221.02727853
48Platelet activation_Homo sapiens_hsa046111.02446096
49Epstein-Barr virus infection_Homo sapiens_hsa051691.01745486
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00923921
51Hepatitis C_Homo sapiens_hsa051601.00406750
52Glycosaminoglycan degradation_Homo sapiens_hsa005310.96835218
53Prolactin signaling pathway_Homo sapiens_hsa049170.94441035
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94096901
55Type I diabetes mellitus_Homo sapiens_hsa049400.93492980
56Autoimmune thyroid disease_Homo sapiens_hsa053200.90776976
57HTLV-I infection_Homo sapiens_hsa051660.88877491
58VEGF signaling pathway_Homo sapiens_hsa043700.88096888
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87654190
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86519570
61Viral carcinogenesis_Homo sapiens_hsa052030.85252193
62Non-small cell lung cancer_Homo sapiens_hsa052230.79627348
63Small cell lung cancer_Homo sapiens_hsa052220.79376572
64Lysosome_Homo sapiens_hsa041420.76582463
65Rheumatoid arthritis_Homo sapiens_hsa053230.71945995
66Colorectal cancer_Homo sapiens_hsa052100.69250360
67Choline metabolism in cancer_Homo sapiens_hsa052310.68526702
68African trypanosomiasis_Homo sapiens_hsa051430.68459719
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67664204
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66562130
71HIF-1 signaling pathway_Homo sapiens_hsa040660.64596468
72GnRH signaling pathway_Homo sapiens_hsa049120.63890488
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.62111507
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.61923934
75Insulin resistance_Homo sapiens_hsa049310.61662699
76Dorso-ventral axis formation_Homo sapiens_hsa043200.60590740
77Notch signaling pathway_Homo sapiens_hsa043300.59855252
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59127402
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57380947
80mTOR signaling pathway_Homo sapiens_hsa041500.55174052
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54132263
82DNA replication_Homo sapiens_hsa030300.53805565
83Phagosome_Homo sapiens_hsa041450.50364187
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.49594853
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47172670
86Endocytosis_Homo sapiens_hsa041440.46118509
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46072118
88Type II diabetes mellitus_Homo sapiens_hsa049300.45797189
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45522895
90MicroRNAs in cancer_Homo sapiens_hsa052060.45502509
91p53 signaling pathway_Homo sapiens_hsa041150.45318526
92FoxO signaling pathway_Homo sapiens_hsa040680.44973559
93Renal cell carcinoma_Homo sapiens_hsa052110.44477517
94Amoebiasis_Homo sapiens_hsa051460.44462426
95MAPK signaling pathway_Homo sapiens_hsa040100.42318609
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42004388
97Base excision repair_Homo sapiens_hsa034100.41584533
98Inositol phosphate metabolism_Homo sapiens_hsa005620.41450654
99Regulation of autophagy_Homo sapiens_hsa041400.40267397
100Prostate cancer_Homo sapiens_hsa052150.38569759
101Caffeine metabolism_Homo sapiens_hsa002320.36730304
102Rap1 signaling pathway_Homo sapiens_hsa040150.34435479
103Long-term potentiation_Homo sapiens_hsa047200.34265280
104ErbB signaling pathway_Homo sapiens_hsa040120.33348339
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.32112266
106Estrogen signaling pathway_Homo sapiens_hsa049150.30903778
107ABC transporters_Homo sapiens_hsa020100.30424476
108Lysine degradation_Homo sapiens_hsa003100.30231188
109Proteoglycans in cancer_Homo sapiens_hsa052050.29989572
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29092993
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.28528684
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28428779
113Systemic lupus erythematosus_Homo sapiens_hsa053220.28050599
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.27039098
115Endometrial cancer_Homo sapiens_hsa052130.26886950
116Ras signaling pathway_Homo sapiens_hsa040140.25935949
117Glioma_Homo sapiens_hsa052140.25161427

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