CCDC88C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a ubiquitously expressed coiled-coil domain-containing protein that interacts with the dishevelled protein and is a negative regulator of the Wnt signalling pathway. The protein encoded by this gene has a PDZ-domain binding motif in its C-terminus with which it interacts with the dishevelled protein. Dishevelled is a scaffold protein involved in the regulation of the Wnt signaling pathway. The Wnt signaling pathway plays an important role in embryonic development, tissue maintenance, and cancer progression. Mutations in this gene cause autosomal recessive, primary non-syndromic congenital hydrocephalus; a condition characterized by excessive accumulation of cerebrospinal fluid in the ventricles of the brain. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.47083778
2negative regulation of cell killing (GO:0031342)5.33546466
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.33546466
4positive thymic T cell selection (GO:0045059)5.30709257
5negative T cell selection (GO:0043383)5.17063882
6positive regulation of gamma-delta T cell activation (GO:0046645)5.16050936
7negative thymic T cell selection (GO:0045060)5.10359763
8regulation of gamma-delta T cell differentiation (GO:0045586)4.93577920
9thymic T cell selection (GO:0045061)4.90526073
10positive T cell selection (GO:0043368)4.83828364
11T cell selection (GO:0045058)4.60508666
12nuclear pore complex assembly (GO:0051292)4.46097932
13regulation of gamma-delta T cell activation (GO:0046643)4.42370805
14pre-miRNA processing (GO:0031054)4.11002386
15positive regulation of granulocyte differentiation (GO:0030854)4.07941230
16response to interleukin-15 (GO:0070672)4.04294790
17interferon-gamma production (GO:0032609)3.96533356
18negative regulation of lymphocyte mediated immunity (GO:0002707)3.91537449
19nuclear pore organization (GO:0006999)3.87890410
20positive regulation by organism of defense response of other organism involved in symbiotic interact3.80218246
21modulation by symbiont of host immune response (GO:0052553)3.80218246
22positive regulation by symbiont of host defense response (GO:0052509)3.80218246
23modulation by symbiont of host defense response (GO:0052031)3.80218246
24modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.80218246
25modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.80218246
26positive regulation of B cell differentiation (GO:0045579)3.79228940
27positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.78945631
28antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.75733284
29antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.75733284
30negative regulation of histone methylation (GO:0031061)3.75270179
31detection of bacterium (GO:0016045)3.75129636
32positive regulation of histone deacetylation (GO:0031065)3.74021214
33negative regulation of erythrocyte differentiation (GO:0045647)3.72512258
34antigen processing and presentation of endogenous antigen (GO:0019883)3.66895973
35detection of other organism (GO:0098543)3.66781818
36positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.65711346
37regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.57242080
38cellular response to interleukin-15 (GO:0071350)3.55040372
39response to muramyl dipeptide (GO:0032495)3.50079870
40regulation of tolerance induction (GO:0002643)3.49160083
41negative regulation of leukocyte mediated immunity (GO:0002704)3.40594864
42histone H3-K4 methylation (GO:0051568)3.36512338
43pore complex assembly (GO:0046931)3.34990607
44regulation of RNA export from nucleus (GO:0046831)3.29568466
45histone H3-K4 trimethylation (GO:0080182)3.28285506
46leukocyte aggregation (GO:0070486)3.27786581
47T cell migration (GO:0072678)3.27008793
48regulation of histone H3-K9 methylation (GO:0051570)3.26513148
49tolerance induction (GO:0002507)3.19023222
50cellular extravasation (GO:0045123)3.17870925
51cilium or flagellum-dependent cell motility (GO:0001539)3.15958440
52mucosal-associated lymphoid tissue development (GO:0048537)3.15955725
53Peyers patch development (GO:0048541)3.15955725
54T cell receptor signaling pathway (GO:0050852)3.15304398
55positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.11647401
56regulation of granulocyte differentiation (GO:0030852)3.11627465
57regulation of interleukin-12 biosynthetic process (GO:0045075)3.11007327
58B cell homeostasis (GO:0001782)3.10239363
59mitotic sister chromatid cohesion (GO:0007064)3.09292422
60negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.08908916
61positive regulation of alpha-beta T cell proliferation (GO:0046641)3.08732868
62neutrophil activation involved in immune response (GO:0002283)3.07591970
63regulation of isotype switching to IgG isotypes (GO:0048302)3.07348896
64T cell costimulation (GO:0031295)3.06221440
65macrophage activation involved in immune response (GO:0002281)3.04493833
66histone H3-K36 demethylation (GO:0070544)3.03950810
67regulation of B cell receptor signaling pathway (GO:0050855)3.01086346
68negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.00429538
69T cell homeostasis (GO:0043029)3.00297082
70lymphocyte costimulation (GO:0031294)2.98724212
71antigen processing and presentation via MHC class Ib (GO:0002475)2.97381844
72B cell receptor signaling pathway (GO:0050853)2.96451496
73germinal center formation (GO:0002467)2.94207759
74intracellular estrogen receptor signaling pathway (GO:0030520)2.92831307
75response to type I interferon (GO:0034340)2.92238477
76regulation of regulatory T cell differentiation (GO:0045589)2.89632106
77type I interferon signaling pathway (GO:0060337)2.89134988
78cellular response to type I interferon (GO:0071357)2.89134988
79antigen receptor-mediated signaling pathway (GO:0050851)2.88973294
80negative regulation of adaptive immune response (GO:0002820)2.88285884
81immunoglobulin mediated immune response (GO:0016064)2.87605877
82regulation of natural killer cell mediated immunity (GO:0002715)2.86993010
83regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.86993010
84histone H4-K16 acetylation (GO:0043984)2.86352555
85histone H4-K12 acetylation (GO:0043983)2.85726546
86cytoplasmic mRNA processing body assembly (GO:0033962)2.84677121
87positive regulation of protein deacetylation (GO:0090312)2.83438664
88negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.83336093
89phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.81211431
90dosage compensation (GO:0007549)2.80667305
91lymphocyte homeostasis (GO:0002260)2.79999321
92regulation of histone H3-K27 methylation (GO:0061085)2.79701992
93regulation of T cell tolerance induction (GO:0002664)2.78983187
94regulation of interferon-beta biosynthetic process (GO:0045357)2.78962270
95positive regulation of gene expression, epigenetic (GO:0045815)2.78287225
96regulation of interleukin-4 production (GO:0032673)2.76863199
97activated T cell proliferation (GO:0050798)2.76014778
98histone lysine methylation (GO:0034968)2.75977639
99regulation of alpha-beta T cell activation (GO:0046634)2.75017018
100DNA duplex unwinding (GO:0032508)2.73324511
101negative regulation of phagocytosis (GO:0050765)2.72604771
102NIK/NF-kappaB signaling (GO:0038061)2.71832008
103negative regulation of T-helper cell differentiation (GO:0045623)2.71827113
104negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.71827113
105regulation of B cell differentiation (GO:0045577)2.71586684
106mast cell activation (GO:0045576)2.71405918
107respiratory burst (GO:0045730)2.71340513
108CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.71193694
109heterochromatin organization (GO:0070828)2.70859093
110positive regulation of Rap GTPase activity (GO:0032854)2.70848879
111V(D)J recombination (GO:0033151)2.70760829
112positive regulation of isotype switching (GO:0045830)2.70038906
113regulation of nucleobase-containing compound transport (GO:0032239)2.69813214
114DNA geometric change (GO:0032392)2.68785246
115positive regulation of interleukin-4 production (GO:0032753)2.68337941
116protein-DNA complex disassembly (GO:0032986)2.68098859
117nucleosome disassembly (GO:0006337)2.68098859
118neutrophil activation (GO:0042119)2.67856353
119RNA stabilization (GO:0043489)2.67761210
120mRNA stabilization (GO:0048255)2.67761210
121negative regulation of innate immune response (GO:0045824)2.67303129
122peptidyl-lysine trimethylation (GO:0018023)2.66426478
123regulation of alpha-beta T cell proliferation (GO:0046640)2.66115395
124negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.64182582
125histone H3-K9 demethylation (GO:0033169)2.63951313
126histone H4-K5 acetylation (GO:0043981)2.63720551
127histone H4-K8 acetylation (GO:0043982)2.63720551
128chromatin assembly (GO:0031497)2.61241245
129trophectodermal cell differentiation (GO:0001829)2.59840968
130positive regulation of interleukin-2 production (GO:0032743)2.57780551
131leukocyte cell-cell adhesion (GO:0007159)2.57175623
132histone lysine demethylation (GO:0070076)2.56390235
133gene silencing (GO:0016458)2.55656699
134natural killer cell differentiation (GO:0001779)2.55486256
135sister chromatid segregation (GO:0000819)2.53538326
136mitotic chromosome condensation (GO:0007076)2.52830003
137positive regulation of tolerance induction (GO:0002645)2.51217897
138histone H3-K9 methylation (GO:0051567)2.49935695
139hepatocyte apoptotic process (GO:0097284)2.48336734
140regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.48113723
141chromatin silencing (GO:0006342)2.46964056
142histone demethylation (GO:0016577)2.45121642
143NLS-bearing protein import into nucleus (GO:0006607)2.44315736
144negative regulation of RNA splicing (GO:0033119)2.44273482
145spliceosomal tri-snRNP complex assembly (GO:0000244)2.44204798
146regulation of interleukin-2 biosynthetic process (GO:0045076)2.43680296
147determination of adult lifespan (GO:0008340)2.43254038
148histone methylation (GO:0016571)2.42337669
149peptidyl-lysine dimethylation (GO:0018027)2.42210092
150regulation of histone methylation (GO:0031060)2.41759297
151gene silencing by RNA (GO:0031047)2.41171757
152negative regulation of T cell mediated immunity (GO:0002710)2.40983874
153peptidyl-lysine methylation (GO:0018022)2.40172498
154negative regulation of histone modification (GO:0031057)2.39192594
155protein localization to kinetochore (GO:0034501)2.38091277
156histone H3-K9 modification (GO:0061647)2.37827434
157mitotic nuclear envelope disassembly (GO:0007077)2.37572686

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.07542149
2* MYC_22102868_ChIP-Seq_BL_Human4.55619180
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.18253334
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.10892242
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.70121344
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.67371250
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.13677895
8VDR_21846776_ChIP-Seq_THP-1_Human2.98195535
9TCF7_22412390_ChIP-Seq_EML_Mouse2.87011740
10* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.63342733
11* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.60647270
12KDM2B_26808549_Chip-Seq_DND41_Human2.59672473
13* MAF_26560356_Chip-Seq_TH1_Human2.47635593
14* UTX_26944678_Chip-Seq_JUKART_Human2.46402160
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.40768164
16* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.40122886
17* RUNX_20019798_ChIP-Seq_JUKART_Human2.26234569
18* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.24916192
19* MYB_26560356_Chip-Seq_TH2_Human2.24752640
20* MYB_26560356_Chip-Seq_TH1_Human2.19365312
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.19187115
22* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.01838990
23CIITA_25753668_ChIP-Seq_RAJI_Human1.88026106
24E2F4_17652178_ChIP-ChIP_JURKAT_Human1.87867573
25* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.86590819
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83345754
27* MAF_26560356_Chip-Seq_TH2_Human1.72509618
28* KDM2B_26808549_Chip-Seq_JURKAT_Human1.72139887
29SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.68279348
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.66876224
31* RUNX1_22412390_ChIP-Seq_EML_Mouse1.66240215
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.64689543
33SCL_19346495_ChIP-Seq_HPC-7_Human1.63488320
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.61646342
35VDR_24763502_ChIP-Seq_THP-1_Human1.59886852
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.59048064
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59029580
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58123570
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56519651
40ZFP281_27345836_Chip-Seq_ESCs_Mouse1.54750197
41IRF8_22096565_ChIP-ChIP_GC-B_Human1.52774555
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.51959341
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.51769117
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.49235781
45IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.46202116
46* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.45379238
47NCOR1_26117541_ChIP-Seq_K562_Human1.43080335
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.42543654
49FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.38704612
50SPI1_23127762_ChIP-Seq_K562_Human1.36657094
51NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.35605708
52CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.32865581
53MYB_21317192_ChIP-Seq_ERMYB_Mouse1.32725739
54* GATA3_27048872_Chip-Seq_THYMUS_Human1.27841699
55RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.27429815
56VDR_24787735_ChIP-Seq_THP-1_Human1.24090349
57* GATA3_26560356_Chip-Seq_TH2_Human1.23368439
58KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21810293
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.20625329
60RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.18850708
61KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.18452067
62MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18009852
63PU_27001747_Chip-Seq_BMDM_Mouse1.15888177
64* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.13444724
65KDM2B_26808549_Chip-Seq_K562_Human1.12975086
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.12187139
67PKCTHETA_26484144_Chip-Seq_BREAST_Human1.11702277
68GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11531045
69LXR_22292898_ChIP-Seq_THP-1_Human1.10850338
70ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09900032
71* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09658587
72RUNX1_27514584_Chip-Seq_MCF-7_Human1.09605913
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08319987
74SALL1_21062744_ChIP-ChIP_HESCs_Human1.07835404
75IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.07834493
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07610579
77TP63_19390658_ChIP-ChIP_HaCaT_Human1.07536450
78* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06176963
79BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.06093286
80KDM5A_27292631_Chip-Seq_BREAST_Human1.05237864
81EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.05220055
82ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04625419
83PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03198473
84CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03096172
85SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02798854
86GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02795568
87* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02720343
88TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01978879
89RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.01593296
90SPI1_23547873_ChIP-Seq_NB4_Human1.01254979
91NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01174008
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00503314
93P68_20966046_ChIP-Seq_HELA_Human1.00013877
94VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99662343
95GATA2_19941826_ChIP-Seq_K562_Human0.99258547
96RACK7_27058665_Chip-Seq_MCF-7_Human0.99156421
97PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98692752
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98428621
99* GATA1_19941827_ChIP-Seq_MEL_Mouse0.98229573
100GATA1_22025678_ChIP-Seq_K562_Human0.97226503
101GATA1_19941826_ChIP-Seq_K562_Human0.95661732
102FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95182811
103LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95163501
104SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94902037
105NANOG_21062744_ChIP-ChIP_HESCs_Human0.94795561
106P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93707285
107CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92994262
108* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92099020
109SMC4_20622854_ChIP-Seq_HELA_Human0.92064049
110DROSHA_22980978_ChIP-Seq_HELA_Human0.91601749
111CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91453913
112SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.91127065
113BCOR_27268052_Chip-Seq_Bcells_Human0.91005538
114PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90959187
115ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.90443854
116CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89436264
117MYC_19079543_ChIP-ChIP_MESCs_Mouse0.89301445
118THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88613138
119IRF8_27001747_Chip-Seq_BMDM_Mouse0.88433358
120ELF1_20517297_ChIP-Seq_JURKAT_Human0.88164783
121GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87973369
122CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86936811
123PHF8_20622854_ChIP-Seq_HELA_Human0.86046151
124CREB1_26743006_Chip-Seq_LNCaP_Human0.85668161
125Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85181212
126CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84697029
127SA1_27219007_Chip-Seq_ERYTHROID_Human0.84590725
128BCL6_27268052_Chip-Seq_Bcells_Human0.84093338
129NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.83556255
130NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.82583926
131* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.82464002
132STAT3_1855785_ChIP-Seq_MESCs_Mouse0.82420569
133RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82341139
134GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82334928

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology3.74674708
2MP0000685_abnormal_immune_system2.77407105
3MP0008057_abnormal_DNA_replication2.73842804
4MP0003724_increased_susceptibility_to2.72370853
5MP0010352_gastrointestinal_tract_polyps2.70708939
6MP0003300_gastrointestinal_ulcer2.68254019
7MP0002396_abnormal_hematopoietic_system2.59067067
8MP0005076_abnormal_cell_differentiation2.53121767
9MP0009278_abnormal_bone_marrow2.50662203
10MP0001800_abnormal_humoral_immune2.50044270
11MP0002398_abnormal_bone_marrow2.36529837
12MP0003303_peritoneal_inflammation2.33780426
13MP0001873_stomach_inflammation2.30648418
14MP0000703_abnormal_thymus_morphology2.29226559
15MP0001790_abnormal_immune_system2.25351119
16MP0005387_immune_system_phenotype2.25351119
17MP0005671_abnormal_response_to2.17550341
18MP0004808_abnormal_hematopoietic_stem2.14746678
19MP0008961_abnormal_basal_metabolism2.12191795
20MP0003111_abnormal_nucleus_morphology2.08883641
21MP0004381_abnormal_hair_follicle2.07894569
22MP0010094_abnormal_chromosome_stability2.07427178
23MP0002420_abnormal_adaptive_immunity1.93203522
24MP0002722_abnormal_immune_system1.93112883
25MP0003866_abnormal_defecation1.91208510
26MP0001819_abnormal_immune_cell1.88540603
27MP0000716_abnormal_immune_system1.87047160
28MP0002166_altered_tumor_susceptibility1.86382033
29MP0002405_respiratory_system_inflammati1.86371752
30MP0000689_abnormal_spleen_morphology1.85061216
31MP0001835_abnormal_antigen_presentation1.83200015
32MP0001545_abnormal_hematopoietic_system1.82365607
33MP0005397_hematopoietic_system_phenotyp1.82365607
34MP0003077_abnormal_cell_cycle1.81233905
35MP0002452_abnormal_antigen_presenting1.80925222
36MP0008877_abnormal_DNA_methylation1.77698054
37MP0002723_abnormal_immune_serum1.75141084
38MP0009785_altered_susceptibility_to1.74878222
39MP0010155_abnormal_intestine_physiology1.74715267
40MP0003787_abnormal_imprinting1.73541710
41MP0002132_abnormal_respiratory_system1.58870237
42MP0002429_abnormal_blood_cell1.58798821
43MP0005000_abnormal_immune_tolerance1.55742342
44MP0008260_abnormal_autophagy1.53839012
45MP0002006_tumorigenesis1.50035873
46MP0010307_abnormal_tumor_latency1.46729046
47MP0000490_abnormal_crypts_of1.45809836
48MP0002148_abnormal_hypersensitivity_rea1.42494610
49MP0004947_skin_inflammation1.41835222
50MP0000350_abnormal_cell_proliferation1.41285371
51MP0004957_abnormal_blastocyst_morpholog1.41008774
52MP0009333_abnormal_splenocyte_physiolog1.38870833
53MP0006082_CNS_inflammation1.38606361
54MP0008058_abnormal_DNA_repair1.38539037
55MP0001730_embryonic_growth_arrest1.38179053
56MP0003172_abnormal_lysosome_physiology1.37765159
57MP0005451_abnormal_body_composition1.37278328
58MP0003693_abnormal_embryo_hatching1.34151037
59MP0001849_ear_inflammation1.33505529
60MP0002822_catalepsy1.31484995
61MP0003436_decreased_susceptibility_to1.28381262
62MP0001533_abnormal_skeleton_physiology1.27597564
63MP0002009_preneoplasia1.26944283
64MP0010234_abnormal_vibrissa_follicle1.26310594
65MP0002019_abnormal_tumor_incidence1.24462148
66MP0005310_abnormal_salivary_gland1.22779029
67MP0002086_abnormal_extraembryonic_tissu1.17290746
68MP0005075_abnormal_melanosome_morpholog1.14434061
69MP0000465_gastrointestinal_hemorrhage1.14407411
70MP0005025_abnormal_response_to1.12774363
71MP0001672_abnormal_embryogenesis/_devel1.12309542
72MP0005380_embryogenesis_phenotype1.12309542
73MP0008007_abnormal_cellular_replicative1.11972333
74MP0003828_pulmonary_edema1.11349499
75MP0003183_abnormal_peptide_metabolism1.10771174
76MP0002653_abnormal_ependyma_morphology1.10223183
77MP0002277_abnormal_respiratory_mucosa1.09714802
78MP0003984_embryonic_growth_retardation1.09180075
79MP0000569_abnormal_digit_pigmentation1.08148571
80MP0002138_abnormal_hepatobiliary_system1.07093393
81MP0002084_abnormal_developmental_patter1.06900179
82MP0002088_abnormal_embryonic_growth/wei1.06549182
83MP0004197_abnormal_fetal_growth/weight/1.04891872
84MP0002933_joint_inflammation1.04744613
85MP0004264_abnormal_extraembryonic_tissu1.02839836
86MP0008995_early_reproductive_senescence1.01894451
87MP0005464_abnormal_platelet_physiology0.99495591
88MP0003566_abnormal_cell_adhesion0.98318344
89MP0003786_premature_aging0.98052769
90MP0004185_abnormal_adipocyte_glucose0.96327683
91MP0008469_abnormal_protein_level0.95978500
92MP0003448_altered_tumor_morphology0.92928854
93MP0003453_abnormal_keratinocyte_physiol0.92318290
94MP0002998_abnormal_bone_remodeling0.91481425
95MP0000313_abnormal_cell_death0.90597002
96MP0001697_abnormal_embryo_size0.90427930
97MP0001663_abnormal_digestive_system0.90302966
98MP0002085_abnormal_embryonic_tissue0.89063972
99MP0003890_abnormal_embryonic-extraembry0.87826114
100MP0001845_abnormal_inflammatory_respons0.87514692
101MP0004883_abnormal_blood_vessel0.86710314
102MP0000858_altered_metastatic_potential0.85951070
103MP0003705_abnormal_hypodermis_morpholog0.85816556
104MP0000733_abnormal_muscle_development0.85659813
105MP0002080_prenatal_lethality0.85547762
106MP0004510_myositis0.83874902
107MP0005023_abnormal_wound_healing0.82301239
108MP0005377_hearing/vestibular/ear_phenot0.81352991
109MP0003878_abnormal_ear_physiology0.81352991
110MP0002925_abnormal_cardiovascular_devel0.81064109
111MP0003045_fibrosis0.80738378
112MP0001853_heart_inflammation0.76442911
113MP0008770_decreased_survivor_rate0.74685820
114MP0003091_abnormal_cell_migration0.73800947
115MP0001929_abnormal_gametogenesis0.72848768
116MP0003191_abnormal_cellular_cholesterol0.72363341
117MP0000477_abnormal_intestine_morphology0.71318128
118MP0001851_eye_inflammation0.70843686
119MP0003656_abnormal_erythrocyte_physiolo0.70426514
120MP0001784_abnormal_fluid_regulation0.69140049
121MP0002419_abnormal_innate_immunity0.68133269
122MP0005621_abnormal_cell_physiology0.67032545
123MP0000249_abnormal_blood_vessel0.60750080
124MP0001986_abnormal_taste_sensitivity0.59811290
125MP0009765_abnormal_xenobiotic_induced0.57741178
126MP0009763_increased_sensitivity_to0.56942746
127MP0004130_abnormal_muscle_cell0.56235864
128MP0002928_abnormal_bile_duct0.56226461
129MP0000470_abnormal_stomach_morphology0.55600922
130MP0009115_abnormal_fat_cell0.54712602
131MP0002796_impaired_skin_barrier0.54105508
132MP0001348_abnormal_lacrimal_gland0.53201708
133MP0005666_abnormal_adipose_tissue0.52178946
134MP0001765_abnormal_ion_homeostasis0.51219241
135MP0002693_abnormal_pancreas_physiology0.49812881
136MP0003943_abnormal_hepatobiliary_system0.49602575
137MP0005381_digestive/alimentary_phenotyp0.49400030
138MP0000015_abnormal_ear_pigmentation0.47900511

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.60475750
2Recurrent bacterial skin infections (HP:0005406)4.34425808
3Recurrent abscess formation (HP:0002722)4.11101149
4T lymphocytopenia (HP:0005403)3.87410923
5Elevated erythrocyte sedimentation rate (HP:0003565)3.74888934
6Nasal polyposis (HP:0100582)3.64036353
7Myositis (HP:0100614)3.60066593
8Abnormality of T cell number (HP:0011839)3.59236931
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.42700754
10Stomatitis (HP:0010280)3.37089132
11Recurrent bronchitis (HP:0002837)3.35964350
12Abnormality of macrophages (HP:0004311)3.20261293
13Abnormal delayed hypersensitivity skin test (HP:0002963)3.19885636
14Gastrointestinal infarctions (HP:0005244)3.16592458
15Panhypogammaglobulinemia (HP:0003139)3.12797722
16Vasculitis (HP:0002633)3.12650725
17Mediastinal lymphadenopathy (HP:0100721)3.11511132
18Dynein arm defect of respiratory motile cilia (HP:0012255)3.08293897
19Absent/shortened dynein arms (HP:0200106)3.08293897
20Spontaneous hematomas (HP:0007420)3.05587341
21Encephalitis (HP:0002383)3.01965875
22Recurrent viral infections (HP:0004429)3.01727972
23Pustule (HP:0200039)3.00693879
24Basal cell carcinoma (HP:0002671)2.99399185
25Recurrent skin infections (HP:0001581)2.97084543
26Hyperacusis (HP:0010780)2.96384277
27Abnormality of the nasal mucosa (HP:0000433)2.94416852
28Abnormal respiratory motile cilium physiology (HP:0012261)2.91528488
29Abnormal respiratory epithelium morphology (HP:0012253)2.90838280
30Abnormal respiratory motile cilium morphology (HP:0005938)2.90838280
31Volvulus (HP:0002580)2.90436644
32Retrobulbar optic neuritis (HP:0100654)2.90086054
33Optic neuritis (HP:0100653)2.90086054
34IgM deficiency (HP:0002850)2.88230469
35Recurrent fungal infections (HP:0002841)2.85940584
36Obstructive lung disease (HP:0006536)2.84658731
37Chronic obstructive pulmonary disease (HP:0006510)2.84658731
38Abnormality of T cells (HP:0002843)2.84036050
39Abnormal ciliary motility (HP:0012262)2.83471036
40Recurrent gram-negative bacterial infections (HP:0005420)2.81595529
41Heterotopia (HP:0002282)2.79338374
42Autoimmune hemolytic anemia (HP:0001890)2.79133422
43Orchitis (HP:0100796)2.77650877
44Gastrointestinal inflammation (HP:0004386)2.76984972
45Inflammation of the large intestine (HP:0002037)2.75954477
46Chronic bronchitis (HP:0004469)2.68537945
47Ependymoma (HP:0002888)2.64442737
48Colitis (HP:0002583)2.62749073
49Granulocytopenia (HP:0001913)2.62511109
50Papilloma (HP:0012740)2.61090512
51Verrucae (HP:0200043)2.61090512
52Chronic otitis media (HP:0000389)2.61059081
53Agammaglobulinemia (HP:0004432)2.60480854
54Rhinitis (HP:0012384)2.59843471
55Gastrointestinal stroma tumor (HP:0100723)2.59279357
56Gingivitis (HP:0000230)2.56515472
57Leukocytosis (HP:0001974)2.54558928
58Combined immunodeficiency (HP:0005387)2.49928291
59Papilledema (HP:0001085)2.44971433
60Prominent nose (HP:0000448)2.38201454
61Obstructive sleep apnea (HP:0002870)2.35673610
62Epistaxis (HP:0000421)2.34528192
63Increased density of long bones (HP:0006392)2.34218006
64Astrocytoma (HP:0009592)2.31926510
65Abnormality of the astrocytes (HP:0100707)2.31926510
66Abnormality of B cell number (HP:0010975)2.29183544
67B lymphocytopenia (HP:0010976)2.29183544
68Long eyelashes (HP:0000527)2.28866516
69Broad palm (HP:0001169)2.28575511
70Osteomyelitis (HP:0002754)2.28569258
71Chronic mucocutaneous candidiasis (HP:0002728)2.26701839
72Recurrent cutaneous fungal infections (HP:0011370)2.26701839
73Increased IgM level (HP:0003496)2.25694388
74Severe combined immunodeficiency (HP:0004430)2.24787756
75Slow saccadic eye movements (HP:0000514)2.22997688
76Eosinophilia (HP:0001880)2.22478282
77Bronchitis (HP:0012387)2.22431841
78Abnormality of eosinophils (HP:0001879)2.20000201
79Recurrent sinusitis (HP:0011108)2.18778535
80Cellulitis (HP:0100658)2.17969839
81Lip pit (HP:0100267)2.15249470
82Hypoplasia of the thymus (HP:0000778)2.14045133
83Recurrent otitis media (HP:0000403)2.12970185
84Absent frontal sinuses (HP:0002688)2.12813393
85Arterial thrombosis (HP:0004420)2.12713950
86Abnormality of the lower motor neuron (HP:0002366)2.11955951
87Pulmonary infiltrates (HP:0002113)2.11355461
88Poikiloderma (HP:0001029)2.10773381
89Urticaria (HP:0001025)2.10689073
90Chronic diarrhea (HP:0002028)2.10251403
91Keratoconjunctivitis sicca (HP:0001097)2.09807929
92Sepsis (HP:0100806)2.05959921
93IgA deficiency (HP:0002720)2.04764241
94Ulnar bowing (HP:0003031)2.03535747
95Thyroiditis (HP:0100646)2.03226190
96Hemoptysis (HP:0002105)2.00806329
97Neonatal hypoglycemia (HP:0001998)2.00119946
98Medulloblastoma (HP:0002885)1.99152431
99Lymphopenia (HP:0001888)1.98120872
100Increased IgE level (HP:0003212)1.97156743
101Anal stenosis (HP:0002025)1.96818555
102Prolonged bleeding time (HP:0003010)1.96705086
103Abnormality of T cell physiology (HP:0011840)1.95938476
104Abnormality of cells of the lymphoid lineage (HP:0012140)1.95691733
105Macroorchidism (HP:0000053)1.93315795
106Aplasia/Hypoplasia of the thymus (HP:0010515)1.93307336
107Gingival bleeding (HP:0000225)1.93290007
108Supernumerary ribs (HP:0005815)1.92793314
109Meningitis (HP:0001287)1.92404096
110Abnormality of oral frenula (HP:0000190)1.92262990
111Pulmonary embolism (HP:0002204)1.91563596
112IgG deficiency (HP:0004315)1.91445866
113Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.91328810
114Short 4th metacarpal (HP:0010044)1.91328810
115Keratoconjunctivitis (HP:0001096)1.91314790
116Vertebral arch anomaly (HP:0008438)1.91003610
117Skin tags (HP:0010609)1.90830646
118Cerebral aneurysm (HP:0004944)1.89479840
119Trigonocephaly (HP:0000243)1.89186721
120Dislocated radial head (HP:0003083)1.89018358
121Increased nuchal translucency (HP:0010880)1.86860503
122Rib fusion (HP:0000902)1.83325466
123Autoimmune thrombocytopenia (HP:0001973)1.81723985
124Depressed nasal tip (HP:0000437)1.80264066
125Chest pain (HP:0100749)1.80042983
126Amyotrophic lateral sclerosis (HP:0007354)1.78574211
127Neoplasm of the oral cavity (HP:0100649)1.76818385
128Limited elbow extension (HP:0001377)1.74328988
129Gastrointestinal carcinoma (HP:0002672)1.74082748
130Malignant gastrointestinal tract tumors (HP:0006749)1.74082748
131Urethral obstruction (HP:0000796)1.73670212
132Abnormality of the radial head (HP:0003995)1.72883167
133Ectopic kidney (HP:0000086)1.72492237
134Sandal gap (HP:0001852)1.72305609
135Truncal obesity (HP:0001956)1.72163361
136Ureteral stenosis (HP:0000071)1.72139735
137Glioma (HP:0009733)1.69837991
138Hypochromic anemia (HP:0001931)1.69621504
139Bronchiectasis (HP:0002110)1.69543497
140Chronic sinusitis (HP:0011109)1.68500770
141Annular pancreas (HP:0001734)1.67794134
142Lymphoma (HP:0002665)1.67280326
143Obsessive-compulsive behavior (HP:0000722)1.67197746
144Abnormality of the intervertebral disk (HP:0005108)1.66477376
145Supernumerary bones of the axial skeleton (HP:0009144)1.66095156
146Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.66055690
147Eczematoid dermatitis (HP:0000976)1.65575251
148Cafe-au-lait spot (HP:0000957)1.65397520
149Intestinal fistula (HP:0100819)1.64786510
150Cutis marmorata (HP:0000965)1.64776463
151Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.64496008
152Viral hepatitis (HP:0006562)1.62786503
153Abnormal platelet volume (HP:0011876)1.62071654

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.70908902
2MAP4K14.50879625
3MAP3K103.72497421
4RIPK43.48802957
5PRPF4B3.23628558
6EEF2K3.19383572
7GRK63.09601088
8STK102.87141672
9ICK2.40276533
10ITK2.01320142
11SIK22.00665175
12BLK1.98864848
13TXK1.91212597
14TRIB31.86644109
15IRAK41.83328957
16SMG11.80232361
17JAK31.76813136
18TYRO31.73332088
19PASK1.67912654
20PKN21.62361129
21NEK21.60202353
22SIK31.58378426
23BRD41.56279484
24FGFR31.55445420
25CSK1.43257687
26FGFR41.42951720
27CDC71.42537154
28TAOK31.37058238
29MAPK151.29520702
30PIM11.29407595
31TAOK11.28628637
32ZAP701.27170230
33ALK1.24575957
34CDK41.18922391
35TYK21.17390260
36BTK1.15387710
37MAP3K71.15366731
38HCK1.12766752
39LRRK21.12646907
40LYN1.09915798
41TTN1.09709977
42CAMKK11.08378537
43TBK11.04738141
44MARK31.03970168
45JAK11.03753173
46RPS6KB21.03583203
47MTOR1.01553797
48EPHB10.97647558
49LCK0.96965440
50PTK60.96469196
51RIPK10.95942052
52STK40.94551777
53CLK10.92889385
54MARK20.91664919
55CHUK0.90591953
56CDK60.90159556
57SYK0.88559853
58PRKD20.87359311
59IRAK10.85722483
60PRKCH0.84137198
61CHEK10.83639465
62CAMK1G0.81162320
63MAP3K130.80430679
64ERN10.79857605
65DYRK1B0.78849238
66CDK90.78737668
67IKBKE0.77456020
68MAP3K30.76644339
69MST40.76543515
70FGR0.75184176
71PDGFRB0.74476186
72MAP3K80.73689305
73MAPK120.73075521
74TNK20.71540774
75MAP3K10.70945989
76ATR0.70192941
77DMPK0.69695113
78YES10.68821684
79BMX0.68154835
80CAMK1D0.67624039
81MELK0.66410085
82SGK30.66315892
83CDK70.64220322
84CSF1R0.63836224
85IRAK20.62447189
86HIPK20.60847727
87CDK20.60816982
88FES0.59655854
89MAP2K30.57837119
90MAP3K140.57428643
91PRKCQ0.57102339
92CAMKK20.56604988
93FGFR20.56281883
94IKBKB0.56170063
95SGK20.55559474
96MAP2K20.55003577
97KIT0.54995749
98ATM0.54757605
99TEC0.54505294
100BMPR20.53780191
101JAK20.53083627
102NEK60.51660967
103RET0.49313552
104STK30.47845141
105RPS6KA10.47828898
106FYN0.46255320
107STK110.45983482
108PDPK10.45766606
109MAPK70.45639766
110MAP3K90.45485920
111CSNK1D0.44335739
112PDK10.43551715
113MAP3K110.40873954
114FGFR10.40687162
115STK240.40527662
116NLK0.39874499
117TRPM70.39643013
118RPS6KL10.39045584
119RPS6KC10.39045584
120RPS6KA40.38805662
121MAPK140.38801696
122RPS6KA60.37771354
123SIK10.37554639
124CDC42BPA0.36778293
125MAPK80.36273407
126LMTK20.35442844
127PTK2B0.35074655
128TSSK60.34455427
129KSR20.33954489
130MAPK110.33307240
131GSK3B0.32861600
132CDK10.32746524

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.38556269
2T cell receptor signaling pathway_Homo sapiens_hsa046602.40811945
3B cell receptor signaling pathway_Homo sapiens_hsa046622.19555737
4Autoimmune thyroid disease_Homo sapiens_hsa053202.15438339
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.72335375
6Type I diabetes mellitus_Homo sapiens_hsa049401.59651676
7Chronic myeloid leukemia_Homo sapiens_hsa052201.58063845
8NF-kappa B signaling pathway_Homo sapiens_hsa040641.54635960
9Antigen processing and presentation_Homo sapiens_hsa046121.54533140
10Intestinal immune network for IgA production_Homo sapiens_hsa046721.48764126
11mRNA surveillance pathway_Homo sapiens_hsa030151.46994568
12Acute myeloid leukemia_Homo sapiens_hsa052211.46663317
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.42926254
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.42487929
15mTOR signaling pathway_Homo sapiens_hsa041501.41836540
16Measles_Homo sapiens_hsa051621.40111969
17Osteoclast differentiation_Homo sapiens_hsa043801.38749831
18Non-small cell lung cancer_Homo sapiens_hsa052231.35934133
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.34309313
20Staphylococcus aureus infection_Homo sapiens_hsa051501.31273263
21Notch signaling pathway_Homo sapiens_hsa043301.30774360
22Viral myocarditis_Homo sapiens_hsa054161.28124061
23Lysine degradation_Homo sapiens_hsa003101.27079215
24Tuberculosis_Homo sapiens_hsa051521.26497939
25Dorso-ventral axis formation_Homo sapiens_hsa043201.25866514
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.24705913
27Hematopoietic cell lineage_Homo sapiens_hsa046401.23938774
28Colorectal cancer_Homo sapiens_hsa052101.22881332
29Herpes simplex infection_Homo sapiens_hsa051681.22865288
30Transcriptional misregulation in cancer_Homo sapiens_hsa052021.22221427
31Endometrial cancer_Homo sapiens_hsa052131.22165540
32Asthma_Homo sapiens_hsa053101.22055294
33HTLV-I infection_Homo sapiens_hsa051661.21480887
34Leishmaniasis_Homo sapiens_hsa051401.19494830
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.17449987
36VEGF signaling pathway_Homo sapiens_hsa043701.16657584
37Thyroid hormone signaling pathway_Homo sapiens_hsa049191.16491289
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15523416
39Chemokine signaling pathway_Homo sapiens_hsa040621.15439814
40Viral carcinogenesis_Homo sapiens_hsa052031.12324462
41Pancreatic cancer_Homo sapiens_hsa052121.10958693
42Toxoplasmosis_Homo sapiens_hsa051451.10421957
43Spliceosome_Homo sapiens_hsa030401.07362801
44Base excision repair_Homo sapiens_hsa034101.06945016
45Neurotrophin signaling pathway_Homo sapiens_hsa047221.04426036
46Hepatitis B_Homo sapiens_hsa051611.04344139
47Small cell lung cancer_Homo sapiens_hsa052221.01529386
48MicroRNAs in cancer_Homo sapiens_hsa052060.99275913
49RNA transport_Homo sapiens_hsa030130.98915548
50Adherens junction_Homo sapiens_hsa045200.95207036
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92581755
52Mismatch repair_Homo sapiens_hsa034300.91484537
53Influenza A_Homo sapiens_hsa051640.91407960
54Platelet activation_Homo sapiens_hsa046110.90877961
55Apoptosis_Homo sapiens_hsa042100.90388194
56DNA replication_Homo sapiens_hsa030300.87636980
57Prolactin signaling pathway_Homo sapiens_hsa049170.86970818
58Cell cycle_Homo sapiens_hsa041100.85786407
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85520116
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83931618
61Malaria_Homo sapiens_hsa051440.83630649
62Epstein-Barr virus infection_Homo sapiens_hsa051690.83402974
63MAPK signaling pathway_Homo sapiens_hsa040100.82935179
64Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82582735
65FoxO signaling pathway_Homo sapiens_hsa040680.80364617
66Inositol phosphate metabolism_Homo sapiens_hsa005620.79702257
67Fanconi anemia pathway_Homo sapiens_hsa034600.79575705
68TNF signaling pathway_Homo sapiens_hsa046680.78298909
69Other glycan degradation_Homo sapiens_hsa005110.77805416
70Non-homologous end-joining_Homo sapiens_hsa034500.76237967
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75671637
72Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75593038
73Renal cell carcinoma_Homo sapiens_hsa052110.75318586
74ErbB signaling pathway_Homo sapiens_hsa040120.75264543
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74216999
76Choline metabolism in cancer_Homo sapiens_hsa052310.73307041
77Glioma_Homo sapiens_hsa052140.73201663
78Graft-versus-host disease_Homo sapiens_hsa053320.72916647
79Shigellosis_Homo sapiens_hsa051310.72258888
80Proteoglycans in cancer_Homo sapiens_hsa052050.72212153
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72097542
82Insulin resistance_Homo sapiens_hsa049310.70041946
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.69752645
84p53 signaling pathway_Homo sapiens_hsa041150.69676066
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69662650
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68493157
87Rap1 signaling pathway_Homo sapiens_hsa040150.68265251
88Prostate cancer_Homo sapiens_hsa052150.67941868
89Thyroid cancer_Homo sapiens_hsa052160.67823829
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67422598
91Estrogen signaling pathway_Homo sapiens_hsa049150.66880759
92Pathways in cancer_Homo sapiens_hsa052000.66543441
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66075649
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65968822
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.64625707
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.63441651
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63303547
98HIF-1 signaling pathway_Homo sapiens_hsa040660.61208202
99Systemic lupus erythematosus_Homo sapiens_hsa053220.60904178
100Legionellosis_Homo sapiens_hsa051340.58988965
101GnRH signaling pathway_Homo sapiens_hsa049120.57962723
102Hepatitis C_Homo sapiens_hsa051600.55481204
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55446631
104Type II diabetes mellitus_Homo sapiens_hsa049300.55290132
105Endocytosis_Homo sapiens_hsa041440.55264064
106RNA degradation_Homo sapiens_hsa030180.55172913
107Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55098925
108Insulin signaling pathway_Homo sapiens_hsa049100.54896862
109Allograft rejection_Homo sapiens_hsa053300.54893556
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54877305
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54509323
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.54086097
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53911222
114African trypanosomiasis_Homo sapiens_hsa051430.53789539
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52930410
116Long-term potentiation_Homo sapiens_hsa047200.52583740
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.52479045
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43450971
119Ras signaling pathway_Homo sapiens_hsa040140.36735923

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