CCDC90B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.59469274
2ATP synthesis coupled proton transport (GO:0015986)5.51367896
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.51367896
4ribosomal small subunit assembly (GO:0000028)5.25187037
5ribosomal small subunit biogenesis (GO:0042274)4.79954163
6chaperone-mediated protein transport (GO:0072321)4.60713542
7viral transcription (GO:0019083)4.52307668
8translational termination (GO:0006415)4.39843200
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.32306595
10pyrimidine nucleobase catabolic process (GO:0006208)4.30874888
11cotranslational protein targeting to membrane (GO:0006613)4.20454794
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.19803461
13maturation of SSU-rRNA (GO:0030490)4.11721079
14protein targeting to ER (GO:0045047)4.10948392
15termination of RNA polymerase III transcription (GO:0006386)4.00000851
16transcription elongation from RNA polymerase III promoter (GO:0006385)4.00000851
17respiratory electron transport chain (GO:0022904)3.96372539
187-methylguanosine mRNA capping (GO:0006370)3.95062080
19RNA capping (GO:0036260)3.93472166
207-methylguanosine RNA capping (GO:0009452)3.93472166
21establishment of protein localization to endoplasmic reticulum (GO:0072599)3.92637766
22protein localization to endoplasmic reticulum (GO:0070972)3.92029915
23behavioral response to nicotine (GO:0035095)3.90859405
24electron transport chain (GO:0022900)3.85598189
25DNA double-strand break processing (GO:0000729)3.83285294
26GTP biosynthetic process (GO:0006183)3.80029866
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.75373364
28mitochondrial respiratory chain complex I assembly (GO:0032981)3.75373364
29NADH dehydrogenase complex assembly (GO:0010257)3.75373364
30quinone biosynthetic process (GO:1901663)3.74641320
31ubiquinone biosynthetic process (GO:0006744)3.74641320
32translational elongation (GO:0006414)3.73248735
33proteasome assembly (GO:0043248)3.71173230
34protein complex biogenesis (GO:0070271)3.70912190
35protein neddylation (GO:0045116)3.68042219
36protein deneddylation (GO:0000338)3.63680805
37CENP-A containing nucleosome assembly (GO:0034080)3.61085996
38negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.59207880
39viral life cycle (GO:0019058)3.58626897
40neural tube formation (GO:0001841)3.58195097
41nucleobase catabolic process (GO:0046113)3.53524760
42oxidative phosphorylation (GO:0006119)3.53403037
43ribosomal large subunit biogenesis (GO:0042273)3.49002595
44positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.48571970
45anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.41359646
46cellular protein complex disassembly (GO:0043624)3.40497969
47regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.40366544
48ubiquinone metabolic process (GO:0006743)3.39378003
49nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.36657139
50chromatin remodeling at centromere (GO:0031055)3.36233693
51presynaptic membrane assembly (GO:0097105)3.35585115
52mitochondrial respiratory chain complex assembly (GO:0033108)3.35185940
53cullin deneddylation (GO:0010388)3.34511122
54behavioral response to ethanol (GO:0048149)3.33832778
55translation (GO:0006412)3.33700853
56DNA deamination (GO:0045006)3.33295057
57regulation of mitochondrial translation (GO:0070129)3.33263803
58protein localization to cilium (GO:0061512)3.31921144
59intraciliary transport (GO:0042073)3.31647775
60signal peptide processing (GO:0006465)3.31389905
61translational initiation (GO:0006413)3.30869888
62platelet dense granule organization (GO:0060155)3.29980415
63gamma-aminobutyric acid transport (GO:0015812)3.28767666
64epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.28380062
65kinetochore assembly (GO:0051382)3.27777789
66indolalkylamine metabolic process (GO:0006586)3.26909938
67negative regulation of ligase activity (GO:0051352)3.26102503
68negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.26102503
69exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.25364565
70viral mRNA export from host cell nucleus (GO:0046784)3.23871493
71transcription elongation from RNA polymerase I promoter (GO:0006362)3.23370155
72nonmotile primary cilium assembly (GO:0035058)3.22817359
73protein polyglutamylation (GO:0018095)3.22802014
74maturation of 5.8S rRNA (GO:0000460)3.21971936
75epithelial cilium movement (GO:0003351)3.20705341
76nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.20196753
77transcription-coupled nucleotide-excision repair (GO:0006283)3.20183834
78termination of RNA polymerase I transcription (GO:0006363)3.17527115
79UTP biosynthetic process (GO:0006228)3.17021993
80cilium morphogenesis (GO:0060271)3.16583665
81response to pheromone (GO:0019236)3.16251595
82guanosine-containing compound biosynthetic process (GO:1901070)3.13664851
83respiratory chain complex IV assembly (GO:0008535)3.11952325
84kinetochore organization (GO:0051383)3.11674264
85G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.09767302
86L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.07800799
87photoreceptor cell maintenance (GO:0045494)3.06572959
88detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.05412810
89establishment of protein localization to mitochondrial membrane (GO:0090151)3.05365169
90rRNA modification (GO:0000154)3.05311491
91anterograde synaptic vesicle transport (GO:0048490)3.03756650
92DNA replication-independent nucleosome assembly (GO:0006336)3.02508614
93DNA replication-independent nucleosome organization (GO:0034724)3.02508614
94deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.02369130
95regulation of cellular amino acid metabolic process (GO:0006521)3.01958460
96cilium organization (GO:0044782)3.00586821
97presynaptic membrane organization (GO:0097090)2.99470161
98cilium assembly (GO:0042384)2.98232424
99establishment of protein localization to Golgi (GO:0072600)2.97722166
100DNA ligation (GO:0006266)2.97564868
101DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.97086604
102spliceosomal complex assembly (GO:0000245)2.94782583
103kynurenine metabolic process (GO:0070189)2.94490553
104transcription from RNA polymerase I promoter (GO:0006360)2.93959752
105positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.93298945
106reflex (GO:0060004)2.92960798
107peptidyl-histidine modification (GO:0018202)2.92596092
108indole-containing compound catabolic process (GO:0042436)2.91565875
109indolalkylamine catabolic process (GO:0046218)2.91565875
110tryptophan catabolic process (GO:0006569)2.91565875
111cellular component biogenesis (GO:0044085)2.91558367
112signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.91159133
113intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.91159133
114mitotic metaphase plate congression (GO:0007080)2.89697543
115ribonucleoprotein complex biogenesis (GO:0022613)2.89141362
116signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.87835077
117signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.87835077
118signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.87835077
119positive regulation of ligase activity (GO:0051351)2.85935578
120L-fucose catabolic process (GO:0042355)2.85862702
121fucose catabolic process (GO:0019317)2.85862702
122L-fucose metabolic process (GO:0042354)2.85862702
123rRNA methylation (GO:0031167)2.85344906
124protein complex disassembly (GO:0043241)2.83203584
125axoneme assembly (GO:0035082)2.82079065
126establishment of integrated proviral latency (GO:0075713)2.82057615
127transmission of nerve impulse (GO:0019226)2.81647542
128RNA-dependent DNA replication (GO:0006278)2.81394189
129spliceosomal snRNP assembly (GO:0000387)2.80328781
130cytochrome complex assembly (GO:0017004)2.78746958
131antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.78254650
132CTP biosynthetic process (GO:0006241)2.78003777
133CTP metabolic process (GO:0046036)2.78003777
134attachment of spindle microtubules to kinetochore (GO:0008608)2.77179993
135glycosphingolipid biosynthetic process (GO:0006688)2.76950386
136detection of light stimulus involved in visual perception (GO:0050908)2.76805810
137detection of light stimulus involved in sensory perception (GO:0050962)2.76805810
138transcription initiation from RNA polymerase I promoter (GO:0006361)2.76120704
139cilium movement (GO:0003341)2.75978792
140purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.75244167
141UTP metabolic process (GO:0046051)2.74808870
142preassembly of GPI anchor in ER membrane (GO:0016254)2.71597681
143regulation of sarcomere organization (GO:0060297)2.71495794
144water-soluble vitamin biosynthetic process (GO:0042364)2.68707331
145regulation of cilium movement (GO:0003352)2.67479571
146cellular ketone body metabolic process (GO:0046950)2.65045883
147positive regulation of mitochondrial fission (GO:0090141)2.64811548
148postsynaptic membrane organization (GO:0001941)2.64216259
149replication fork processing (GO:0031297)2.63026266
150regulation of timing of cell differentiation (GO:0048505)2.62622398
151regulation of development, heterochronic (GO:0040034)2.62505774
152DNA integration (GO:0015074)2.62481222
153neuronal action potential (GO:0019228)2.62305186
154tachykinin receptor signaling pathway (GO:0007217)2.62267081
155tryptophan metabolic process (GO:0006568)2.59519646
156righting reflex (GO:0060013)2.58697522
157protein-cofactor linkage (GO:0018065)2.58188980
158neuron cell-cell adhesion (GO:0007158)2.55831272
159regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.54731516
160prenylation (GO:0097354)2.54608094
161protein prenylation (GO:0018342)2.54608094
162head development (GO:0060322)2.52594643
163negative regulation of mast cell activation (GO:0033004)2.51245335
164cilium or flagellum-dependent cell motility (GO:0001539)2.50581255
165C4-dicarboxylate transport (GO:0015740)2.49641735
166limb bud formation (GO:0060174)2.48665698
167auditory behavior (GO:0031223)2.48552626
168tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.48264502
169RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.48264502
170olfactory bulb development (GO:0021772)2.47865205
171regulation of mesoderm development (GO:2000380)2.45783982
172retinal cone cell development (GO:0046549)2.45750569
173GPI anchor metabolic process (GO:0006505)2.45397780
174indole-containing compound metabolic process (GO:0042430)2.43502744
175protein targeting to Golgi (GO:0000042)2.43285745
176appendage development (GO:0048736)2.42391626
177limb development (GO:0060173)2.42391626
178protein localization to synapse (GO:0035418)2.40830957
179negative regulation of translation, ncRNA-mediated (GO:0040033)2.40454623
180regulation of translation, ncRNA-mediated (GO:0045974)2.40454623
181negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.40454623
182retinal ganglion cell axon guidance (GO:0031290)2.40300842
183negative regulation of cytosolic calcium ion concentration (GO:0051481)2.39791578
184photoreceptor cell development (GO:0042461)2.39585276
185regulation of telomere maintenance (GO:0032204)2.39053795
186inner ear receptor stereocilium organization (GO:0060122)2.38405944
187anterograde axon cargo transport (GO:0008089)2.38174269
188kidney morphogenesis (GO:0060993)2.38170026
189somite development (GO:0061053)2.38118457

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.86829279
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.48596378
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.92332708
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.88905522
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.57060439
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.46633867
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.44057208
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.33232407
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.32585000
10ZNF274_21170338_ChIP-Seq_K562_Hela3.28060249
11* CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.20470560
12GBX2_23144817_ChIP-Seq_PC3_Human3.17368641
13* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.11699610
14CREB1_15753290_ChIP-ChIP_HEK293T_Human3.05255612
15* ETS1_20019798_ChIP-Seq_JURKAT_Human3.03817994
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.90402303
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.82014512
18EZH2_22144423_ChIP-Seq_EOC_Human2.78510076
19TAF15_26573619_Chip-Seq_HEK293_Human2.78119082
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.65529868
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.51994638
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.47902434
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.37962761
24P300_19829295_ChIP-Seq_ESCs_Human2.32395928
25ELK1_19687146_ChIP-ChIP_HELA_Human2.32015419
26RBPJ_22232070_ChIP-Seq_NCS_Mouse2.30070878
27* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.27995191
28VDR_23849224_ChIP-Seq_CD4+_Human2.26272474
29* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.20275299
30E2F1_18555785_ChIP-Seq_MESCs_Mouse2.18029108
31CTBP1_25329375_ChIP-Seq_LNCAP_Human2.15608861
32* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.12385104
33MYC_19079543_ChIP-ChIP_MESCs_Mouse2.11566021
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.11093359
35* DCP1A_22483619_ChIP-Seq_HELA_Human2.10786255
36E2F4_17652178_ChIP-ChIP_JURKAT_Human2.08944244
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.08918909
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.04549309
39EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.00241225
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99518967
41TTF2_22483619_ChIP-Seq_HELA_Human1.96148667
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.88363320
43NELFA_20434984_ChIP-Seq_ESCs_Mouse1.87234311
44* XRN2_22483619_ChIP-Seq_HELA_Human1.84394098
45FOXP3_21729870_ChIP-Seq_TREG_Human1.80030841
46* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76955377
47ER_23166858_ChIP-Seq_MCF-7_Human1.76128371
48SMAD4_21799915_ChIP-Seq_A2780_Human1.76118833
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73014573
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72909677
51AR_21909140_ChIP-Seq_LNCAP_Human1.72387418
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.71677868
53E2F7_22180533_ChIP-Seq_HELA_Human1.71277455
54* GABP_19822575_ChIP-Seq_HepG2_Human1.70753711
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.69191372
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.68632068
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.66517941
58VDR_22108803_ChIP-Seq_LS180_Human1.65991361
59FUS_26573619_Chip-Seq_HEK293_Human1.65153785
60CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.65112318
61POU5F1_16153702_ChIP-ChIP_HESCs_Human1.63973682
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63681836
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.62877325
64CBP_20019798_ChIP-Seq_JUKART_Human1.62877325
65ELK1_22589737_ChIP-Seq_MCF10A_Human1.61365952
66STAT3_23295773_ChIP-Seq_U87_Human1.61157570
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.60630160
68MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.58973050
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58543888
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.57639130
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56018129
72YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55683043
73* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.55163180
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54889884
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.53880865
76BCAT_22108803_ChIP-Seq_LS180_Human1.52359517
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51535109
78EWS_26573619_Chip-Seq_HEK293_Human1.50513027
79* AR_25329375_ChIP-Seq_VCAP_Human1.48258129
80MYC_18940864_ChIP-ChIP_HL60_Human1.44896808
81NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44382739
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.43463962
83TCF4_23295773_ChIP-Seq_U87_Human1.40809397
84PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40520474
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.38900076
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38900076
87* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36589409
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35708302
89IRF1_19129219_ChIP-ChIP_H3396_Human1.34675134
90EZH2_27294783_Chip-Seq_NPCs_Mouse1.34585062
91ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.33423470
92KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33413512
93MYCN_18555785_ChIP-Seq_MESCs_Mouse1.33146532
94ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32107275
95* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30360737
96RUNX2_22187159_ChIP-Seq_PCA_Human1.30201535
97* TCF4_22108803_ChIP-Seq_LS180_Human1.30043032
98TP53_22573176_ChIP-Seq_HFKS_Human1.30041509
99POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29975865
100TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.28905555
101POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27995886
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27531164
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.27032883
104NANOG_19829295_ChIP-Seq_ESCs_Human1.26077197
105SOX2_19829295_ChIP-Seq_ESCs_Human1.26077197
106AR_21572438_ChIP-Seq_LNCaP_Human1.25632327
107REST_21632747_ChIP-Seq_MESCs_Mouse1.24975315
108YY1_21170310_ChIP-Seq_MESCs_Mouse1.24241569
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21897278
110NFE2_27457419_Chip-Seq_LIVER_Mouse1.21286855
111FLI1_21867929_ChIP-Seq_TH2_Mouse1.18413573
112ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16791565
113POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16616359
114NANOG_18555785_ChIP-Seq_MESCs_Mouse1.16202792
115FLI1_27457419_Chip-Seq_LIVER_Mouse1.14974580
116GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13288546
117SALL1_21062744_ChIP-ChIP_HESCs_Human1.13217725
118P53_22387025_ChIP-Seq_ESCs_Mouse1.12930194
119* SMAD4_21741376_ChIP-Seq_EPCs_Human1.12132247
120ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11648719
121TP63_19390658_ChIP-ChIP_HaCaT_Human1.10927590
122* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10788892
123PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10545500
124PRDM14_20953172_ChIP-Seq_ESCs_Human1.10544520
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10147305
126CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09297720
127FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08163841
128FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07712499
129JUN_21703547_ChIP-Seq_K562_Human1.07531284
130CRX_20693478_ChIP-Seq_RETINA_Mouse1.07150913
131SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06924460
132TAL1_26923725_Chip-Seq_HPCs_Mouse1.05656798
133SOX2_21211035_ChIP-Seq_LN229_Gbm1.04672731
134SOX17_20123909_ChIP-Seq_XEN_Mouse1.04286566
135E2F1_18555785_Chip-Seq_ESCs_Mouse1.03815128
136KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03588188
137* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03277626
138* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02915108
139TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01225451
140GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99716485
141SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98496092
142CBX2_27304074_Chip-Seq_ESCs_Mouse0.97030016
143FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96933908
144EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96411356
145SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96338591
146CDX2_22108803_ChIP-Seq_LS180_Human0.95718253
147FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95503549
148FOXA1_25329375_ChIP-Seq_VCAP_Human0.95503549
149BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95351383
150BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94576595
151MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.93782129
152FOXM1_23109430_ChIP-Seq_U2OS_Human0.93443333
153DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91227989
154* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.90677523
155CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88087239
156TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.87067947
157RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85348373
158SOX2_16153702_ChIP-ChIP_HESCs_Human0.81637593
159* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.78101913
160RNF2_27304074_Chip-Seq_NSC_Mouse0.77308983
161NANOG_16153702_ChIP-ChIP_HESCs_Human0.75367937
162SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.74135303
163KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.72723458
164CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.72718726
165* CIITA_25753668_ChIP-Seq_RAJI_Human0.71931121
166TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.71239671
167HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.70914083
168GATA4_21415370_ChIP-Seq_HL-1_Mouse0.69026290
169NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.68244630
170PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.66011098
171IGF1R_20145208_ChIP-Seq_DFB_Human0.65740535

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.90388780
2MP0002102_abnormal_ear_morphology3.50105737
3MP0009379_abnormal_foot_pigmentation3.16449233
4MP0000569_abnormal_digit_pigmentation3.09547700
5MP0003693_abnormal_embryo_hatching2.82935647
6MP0002938_white_spotting2.78146968
7MP0003880_abnormal_central_pattern2.66849251
8MP0003718_maternal_effect2.54753038
9MP0006292_abnormal_olfactory_placode2.37620689
10MP0002736_abnormal_nociception_after2.25812496
11MP0003787_abnormal_imprinting2.19918084
12MP0006276_abnormal_autonomic_nervous2.19824105
13MP0001968_abnormal_touch/_nociception2.19608032
14MP0004957_abnormal_blastocyst_morpholog2.18930429
15MP0001984_abnormal_olfaction2.11782064
16MP0005551_abnormal_eye_electrophysiolog2.08221545
17MP0003646_muscle_fatigue2.07791837
18MP0000049_abnormal_middle_ear2.06384168
19MP0000566_synostosis2.04222428
20MP0005171_absent_coat_pigmentation2.02471894
21MP0003195_calcinosis1.98804545
22MP0009046_muscle_twitch1.98611818
23MP0003890_abnormal_embryonic-extraembry1.94019667
24MP0002638_abnormal_pupillary_reflex1.92852821
25MP0003123_paternal_imprinting1.84451436
26MP0003011_delayed_dark_adaptation1.83405783
27MP0005503_abnormal_tendon_morphology1.82877461
28MP0008932_abnormal_embryonic_tissue1.79557820
29MP0006036_abnormal_mitochondrial_physio1.76349050
30MP0003950_abnormal_plasma_membrane1.75540396
31MP0000778_abnormal_nervous_system1.75049647
32MP0004133_heterotaxia1.71689962
33MP0009745_abnormal_behavioral_response1.71491068
34MP0002282_abnormal_trachea_morphology1.68876777
35MP0003077_abnormal_cell_cycle1.65832681
36MP0008058_abnormal_DNA_repair1.65253848
37MP0002272_abnormal_nervous_system1.65221355
38MP0004142_abnormal_muscle_tone1.64385177
39MP0009250_abnormal_appendicular_skeleto1.64146138
40MP0001486_abnormal_startle_reflex1.63143768
41MP0006072_abnormal_retinal_apoptosis1.61556608
42MP0010094_abnormal_chromosome_stability1.61360000
43MP0002735_abnormal_chemical_nociception1.61276848
44MP0004215_abnormal_myocardial_fiber1.59425449
45MP0003186_abnormal_redox_activity1.58962880
46MP0001986_abnormal_taste_sensitivity1.55751797
47MP0005645_abnormal_hypothalamus_physiol1.53661112
48MP0009697_abnormal_copulation1.52375851
49MP0000372_irregular_coat_pigmentation1.50287476
50MP0008789_abnormal_olfactory_epithelium1.50118966
51MP0008007_abnormal_cellular_replicative1.48122351
52MP0009384_cardiac_valve_regurgitation1.46513788
53MP0005499_abnormal_olfactory_system1.46227957
54MP0005394_taste/olfaction_phenotype1.46227957
55MP0009053_abnormal_anal_canal1.45726345
56MP0005408_hypopigmentation1.45712710
57MP0002572_abnormal_emotion/affect_behav1.45609439
58MP0003937_abnormal_limbs/digits/tail_de1.45195784
59MP0008438_abnormal_cutaneous_collagen1.44872401
60MP0002249_abnormal_larynx_morphology1.43026973
61MP0003111_abnormal_nucleus_morphology1.42752846
62MP0006035_abnormal_mitochondrial_morpho1.42689938
63MP0004145_abnormal_muscle_electrophysio1.42298237
64MP0003315_abnormal_perineum_morphology1.41746284
65MP0003635_abnormal_synaptic_transmissio1.39713211
66MP0001485_abnormal_pinna_reflex1.37803329
67MP0002557_abnormal_social/conspecific_i1.36694757
68MP0000631_abnormal_neuroendocrine_gland1.33632637
69MP0001529_abnormal_vocalization1.33002982
70MP0004084_abnormal_cardiac_muscle1.32919891
71MP0005646_abnormal_pituitary_gland1.32265537
72MP0010030_abnormal_orbit_morphology1.30669953
73MP0000749_muscle_degeneration1.28877378
74MP0002751_abnormal_autonomic_nervous1.28740989
75MP0005423_abnormal_somatic_nervous1.28086689
76MP0003121_genomic_imprinting1.27300779
77MP0004924_abnormal_behavior1.24816688
78MP0005386_behavior/neurological_phenoty1.24816688
79MP0003137_abnormal_impulse_conducting1.24371364
80MP0004859_abnormal_synaptic_plasticity1.24291281
81MP0000427_abnormal_hair_cycle1.24267017
82MP0002067_abnormal_sensory_capabilities1.23429270
83MP0003941_abnormal_skin_development1.23121793
84MP0002734_abnormal_mechanical_nocicepti1.22778403
85MP0003786_premature_aging1.22708921
86MP0002184_abnormal_innervation1.21312459
87MP0001905_abnormal_dopamine_level1.20525788
88MP0003119_abnormal_digestive_system1.20248915
89MP0002177_abnormal_outer_ear1.18548816
90MP0001293_anophthalmia1.17009040
91MP0005084_abnormal_gallbladder_morpholo1.16939491
92MP0002063_abnormal_learning/memory/cond1.16610822
93MP0002064_seizures1.15842470
94MP0001970_abnormal_pain_threshold1.14781793
95MP0004270_analgesia1.14407528
96MP0005174_abnormal_tail_pigmentation1.13808073
97MP0003942_abnormal_urinary_system1.13713594
98MP0002928_abnormal_bile_duct1.13024328
99MP0003755_abnormal_palate_morphology1.12576048
100MP0002752_abnormal_somatic_nervous1.10484951
101MP0001286_abnormal_eye_development1.10437492
102MP0008995_early_reproductive_senescence1.08489966
103MP0008872_abnormal_physiological_respon1.07914329
104MP0003122_maternal_imprinting1.07302420
105MP0002653_abnormal_ependyma_morphology1.07288309
106MP0003567_abnormal_fetal_cardiomyocyte1.05931194
107MP0004043_abnormal_pH_regulation1.05900717
108MP0005508_abnormal_skeleton_morphology1.05446733
109MP0004885_abnormal_endolymph1.04863668
110MP0001501_abnormal_sleep_pattern1.04514384
111MP0002733_abnormal_thermal_nociception1.03987185
112MP0002822_catalepsy1.03515653
113MP0004036_abnormal_muscle_relaxation1.02788004
114MP0005195_abnormal_posterior_eye1.01354836
115MP0000647_abnormal_sebaceous_gland1.01107713
116MP0005187_abnormal_penis_morphology1.00847356
117MP0010386_abnormal_urinary_bladder1.00576464
118MP0000955_abnormal_spinal_cord1.00414392
119MP0003385_abnormal_body_wall0.99463623
120MP0001727_abnormal_embryo_implantation0.98560614
121MP0002882_abnormal_neuron_morphology0.95996399
122MP0000751_myopathy0.95610450
123MP0005275_abnormal_skin_tensile0.93962719
124MP0003878_abnormal_ear_physiology0.92897281
125MP0005377_hearing/vestibular/ear_phenot0.92897281
126MP0002095_abnormal_skin_pigmentation0.91515428
127MP0000516_abnormal_urinary_system0.91400426
128MP0005367_renal/urinary_system_phenotyp0.91400426
129MP0000026_abnormal_inner_ear0.89364952
130MP0001119_abnormal_female_reproductive0.88827434
131MP0002210_abnormal_sex_determination0.88589579
132MP0003938_abnormal_ear_development0.88303535
133MP0004742_abnormal_vestibular_system0.88066566
134MP0002837_dystrophic_cardiac_calcinosis0.87526604
135MP0004272_abnormal_basement_membrane0.87017063
136MP0005391_vision/eye_phenotype0.85588988
137MP0005085_abnormal_gallbladder_physiolo0.85317380
138MP0002972_abnormal_cardiac_muscle0.84693486
139MP0002233_abnormal_nose_morphology0.84238121
140MP0000750_abnormal_muscle_regeneration0.83775237
141MP0004147_increased_porphyrin_level0.83351133
142MP0005395_other_phenotype0.82801332
143MP0006138_congestive_heart_failure0.82633923
144MP0002160_abnormal_reproductive_system0.82259334
145MP0000653_abnormal_sex_gland0.81785457
146MP0000537_abnormal_urethra_morphology0.81117741
147MP0000462_abnormal_digestive_system0.81116504
148MP0002163_abnormal_gland_morphology0.80231539
149MP0005330_cardiomyopathy0.79988895
150MP0002109_abnormal_limb_morphology0.79968274
151MP0002116_abnormal_craniofacial_bone0.79550688
152MP0006054_spinal_hemorrhage0.79422110
153MP0005253_abnormal_eye_physiology0.79329212
154MP0002932_abnormal_joint_morphology0.78982327
155MP0005379_endocrine/exocrine_gland_phen0.77988249
156MP0008877_abnormal_DNA_methylation0.77529442
157MP0001879_abnormal_lymphatic_vessel0.76086124
158MP0008057_abnormal_DNA_replication0.75119143
159MP0001188_hyperpigmentation0.74579330
160MP0005257_abnormal_intraocular_pressure0.74336771
161MP0001145_abnormal_male_reproductive0.74295693
162MP0002277_abnormal_respiratory_mucosa0.74215921
163MP0002234_abnormal_pharynx_morphology0.73217456
164MP0003279_aneurysm0.72730470
165MP0002132_abnormal_respiratory_system0.71949323

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.81707100
2Abnormal mitochondria in muscle tissue (HP:0008316)4.36572536
3Increased serum pyruvate (HP:0003542)4.18208734
4Abnormality of glycolysis (HP:0004366)4.18208734
5Mitochondrial inheritance (HP:0001427)3.91673835
6Progressive macrocephaly (HP:0004481)3.86209232
7Acute encephalopathy (HP:0006846)3.76950644
8Increased CSF lactate (HP:0002490)3.70439209
9Reticulocytopenia (HP:0001896)3.58116872
10Abnormality of cells of the erythroid lineage (HP:0012130)3.57682530
11Abnormal number of erythroid precursors (HP:0012131)3.42971659
12Hepatocellular necrosis (HP:0001404)3.32662063
13Birth length less than 3rd percentile (HP:0003561)3.31690876
14Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.31277274
15Decreased activity of mitochondrial respiratory chain (HP:0008972)3.31277274
16Hepatic necrosis (HP:0002605)3.31061203
17Increased hepatocellular lipid droplets (HP:0006565)3.19698528
18Abnormality of the renal medulla (HP:0100957)3.13614510
19Renal Fanconi syndrome (HP:0001994)3.12594500
20Hyperventilation (HP:0002883)3.01747987
21Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.99798273
22Lipid accumulation in hepatocytes (HP:0006561)2.99492735
23Chronic hepatic failure (HP:0100626)2.95625516
24Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.90507440
25True hermaphroditism (HP:0010459)2.87411142
26Genital tract atresia (HP:0001827)2.84770916
27Exercise intolerance (HP:0003546)2.83255431
28Pancreatic cysts (HP:0001737)2.82552386
29Abnormality of the renal cortex (HP:0011035)2.79023908
30Aplasia/Hypoplasia of the tibia (HP:0005772)2.77898402
31Breast hypoplasia (HP:0003187)2.77101472
32Pancreatic fibrosis (HP:0100732)2.75693659
33Vaginal atresia (HP:0000148)2.71475628
343-Methylglutaconic aciduria (HP:0003535)2.66684947
35Aplasia/Hypoplasia of the tongue (HP:0010295)2.65082143
36Increased serum lactate (HP:0002151)2.60507767
37Cystic liver disease (HP:0006706)2.59145630
38Congenital stationary night blindness (HP:0007642)2.58623944
39Lactic acidosis (HP:0003128)2.58150265
40Medial flaring of the eyebrow (HP:0010747)2.56352575
41Abolished electroretinogram (ERG) (HP:0000550)2.45728061
42Facial cleft (HP:0002006)2.44813118
43Abnormality of the labia minora (HP:0012880)2.43239234
44Congenital, generalized hypertrichosis (HP:0004540)2.39327005
45Broad-based gait (HP:0002136)2.38654664
46Postaxial foot polydactyly (HP:0001830)2.37671076
47Respiratory failure (HP:0002878)2.37206178
48Attenuation of retinal blood vessels (HP:0007843)2.36586856
49Renal cortical cysts (HP:0000803)2.36369736
50Gaze-evoked nystagmus (HP:0000640)2.35402189
51Polyphagia (HP:0002591)2.34834754
52Progressive cerebellar ataxia (HP:0002073)2.34536653
53Lissencephaly (HP:0001339)2.33178144
54Genetic anticipation (HP:0003743)2.32053666
55Macrocytic anemia (HP:0001972)2.31929858
56Volvulus (HP:0002580)2.30681481
57Patchy hypopigmentation of hair (HP:0011365)2.30657646
58Type II lissencephaly (HP:0007260)2.30438986
59Drooling (HP:0002307)2.28565103
60Adrenal hypoplasia (HP:0000835)2.28415749
61Hypothermia (HP:0002045)2.26693618
62Hypoplastic left heart (HP:0004383)2.26605484
63Congenital hepatic fibrosis (HP:0002612)2.26365326
64Leukodystrophy (HP:0002415)2.25943637
65Optic disc pallor (HP:0000543)2.23895500
66Cerebral edema (HP:0002181)2.19981189
67Absent speech (HP:0001344)2.19628370
68Progressive inability to walk (HP:0002505)2.19333731
69Increased intramyocellular lipid droplets (HP:0012240)2.19219139
70Exertional dyspnea (HP:0002875)2.18307730
71Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.18051826
72Abnormality of alanine metabolism (HP:0010916)2.18051826
73Hyperalaninemia (HP:0003348)2.18051826
74Inability to walk (HP:0002540)2.17791214
75Focal motor seizures (HP:0011153)2.17340441
76Intestinal atresia (HP:0011100)2.16987713
77Proximal tubulopathy (HP:0000114)2.16881667
78Aplastic anemia (HP:0001915)2.15130782
79Postaxial hand polydactyly (HP:0001162)2.13219024
80Median cleft lip (HP:0000161)2.12794846
81Poor coordination (HP:0002370)2.12143248
82Tubular atrophy (HP:0000092)2.11234661
83Bile duct proliferation (HP:0001408)2.11070384
84Abnormal biliary tract physiology (HP:0012439)2.11070384
85Abnormality of midbrain morphology (HP:0002418)2.10937491
86Molar tooth sign on MRI (HP:0002419)2.10937491
87Focal seizures (HP:0007359)2.05525762
88Febrile seizures (HP:0002373)2.04397909
89Bony spicule pigmentary retinopathy (HP:0007737)2.03294285
90Pallor (HP:0000980)2.03071688
91Male pseudohermaphroditism (HP:0000037)2.03015553
92Narrow forehead (HP:0000341)2.02902263
93Popliteal pterygium (HP:0009756)2.02713696
94Thyroid-stimulating hormone excess (HP:0002925)2.00311633
95Type I transferrin isoform profile (HP:0003642)2.00117573
96Rough bone trabeculation (HP:0100670)2.00050901
97Excessive salivation (HP:0003781)1.99719131
98Increased muscle lipid content (HP:0009058)1.98873478
99Abnormality of the phalanges of the 5th finger (HP:0004213)1.97773360
100Protruding tongue (HP:0010808)1.97220010
101Methylmalonic aciduria (HP:0012120)1.96075745
102Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.95520813
103Short tibia (HP:0005736)1.95516419
104Tubulointerstitial nephritis (HP:0001970)1.94266426
105Dialeptic seizures (HP:0011146)1.93519285
106Hyperglycinemia (HP:0002154)1.92961677
107Limb dystonia (HP:0002451)1.92935711
108Type 2 muscle fiber atrophy (HP:0003554)1.91759334
109Respiratory difficulties (HP:0002880)1.91184845
110Pendular nystagmus (HP:0012043)1.90618726
111Retinal dysplasia (HP:0007973)1.90550358
112Optic nerve hypoplasia (HP:0000609)1.90502046
113White forelock (HP:0002211)1.90197289
114Pachygyria (HP:0001302)1.88381729
115Congenital primary aphakia (HP:0007707)1.87344846
116Methylmalonic acidemia (HP:0002912)1.86845656
117Cerebellar dysplasia (HP:0007033)1.86692510
118Specific learning disability (HP:0001328)1.86228742
119Small hand (HP:0200055)1.85939748
120Abnormality of the axillary hair (HP:0100134)1.85927506
121Abnormality of secondary sexual hair (HP:0009888)1.85927506
122Short foot (HP:0001773)1.85341332
123Short middle phalanx of the 5th finger (HP:0004220)1.84788126
124Aplasia/hypoplasia of the uterus (HP:0008684)1.83917993
125Hypoplastic heart (HP:0001961)1.83824226
126Nephrogenic diabetes insipidus (HP:0009806)1.83662474
127Colon cancer (HP:0003003)1.83492128
128Furrowed tongue (HP:0000221)1.83248071
129Abnormality of renal resorption (HP:0011038)1.81045403
130Supernumerary spleens (HP:0009799)1.80832186
131Hypoplasia of the uterus (HP:0000013)1.80531783
132Stenosis of the external auditory canal (HP:0000402)1.80494425
133Occipital encephalocele (HP:0002085)1.80317193
134Fibular aplasia (HP:0002990)1.80185915
135Bifid tongue (HP:0010297)1.79594817
136Abnormal drinking behavior (HP:0030082)1.78968645
137Polydipsia (HP:0001959)1.78968645
138Abnormality of macular pigmentation (HP:0008002)1.78412577
139Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.78062478
140Dandy-Walker malformation (HP:0001305)1.78038683
141Nephronophthisis (HP:0000090)1.77479839
142Gait imbalance (HP:0002141)1.77464368
14311 pairs of ribs (HP:0000878)1.77203665
144Atonic seizures (HP:0010819)1.76832285
145CNS hypomyelination (HP:0003429)1.76487120
146Hypoplasia of the fovea (HP:0007750)1.76308429
147Aplasia/Hypoplasia of the fovea (HP:0008060)1.76308429
148Aplasia/Hypoplasia of the sacrum (HP:0008517)1.75761762
149Oligodactyly (hands) (HP:0001180)1.75700828
150Broad foot (HP:0001769)1.75682961
151Sclerocornea (HP:0000647)1.75289250
152Patellar aplasia (HP:0006443)1.74619262
153Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74280043
154Irregular epiphyses (HP:0010582)1.74038047
155Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.73608480
156Astigmatism (HP:0000483)1.72602806
157Abnormality of the anterior horn cell (HP:0006802)1.72447212
158Degeneration of anterior horn cells (HP:0002398)1.72447212
159Glycosuria (HP:0003076)1.71585356
160Abnormality of urine glucose concentration (HP:0011016)1.71585356
161Abnormal ciliary motility (HP:0012262)1.69634001
162X-linked dominant inheritance (HP:0001423)1.68933416
163Natal tooth (HP:0000695)1.68380355
164Pterygium (HP:0001059)1.67916847
165Preaxial hand polydactyly (HP:0001177)1.66147695
166Anencephaly (HP:0002323)1.65704439
167Chromsome breakage (HP:0040012)1.65522954
168Aplasia/Hypoplasia of the patella (HP:0006498)1.64734593
169Aplasia/Hypoplasia of the lens (HP:0008063)1.64248319

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.06242683
2STK163.05243435
3MAP4K22.98659060
4NME22.79116056
5MAP3K42.60968869
6WEE12.49284587
7TRIM282.41884433
8ACVR1B2.28490524
9CCNB12.20692520
10MARK12.19586998
11MUSK2.19166589
12PBK2.17497016
13VRK12.16028005
14MYLK2.09212593
15DYRK22.06555996
16BRSK22.03444203
17MAP2K72.02659416
18DYRK31.96774899
19PLK41.94484324
20CDK81.88735237
21SRPK11.86649309
22BRAF1.85257789
23BMPR1B1.83271637
24MKNK11.82417123
25EIF2AK11.82037146
26ARAF1.73303143
27PINK11.70797922
28OBSCN1.66956362
29PIK3CA1.65536856
30NME11.64759156
31EIF2AK31.63599513
32GRK11.57609206
33BCKDK1.56680869
34MAP3K31.54280515
35ERBB31.53516259
36TGFBR11.42999666
37MST41.41981454
38TTK1.37625788
39CSNK1G21.33189247
40INSRR1.32287199
41CASK1.29492278
42PAK31.27547135
43EPHB21.22388680
44PLK11.22362521
45PLK21.22167010
46NUAK11.22125899
47MAPK131.21872457
48MOS1.19749905
49MAPKAPK51.19083019
50CSNK1A1L1.13410927
51PLK31.12761518
52TAOK31.11708653
53MKNK21.11503761
54EIF2AK21.09476509
55PIM21.09452671
56CDC71.07148909
57STK38L1.05250945
58RPS6KA51.03970105
59RPS6KA41.03066230
60PRKCG1.02329345
61ILK1.01726099
62BCR0.99205787
63AURKB0.96981470
64NEK60.96591388
65EPHA40.95347777
66WNK40.94881285
67LMTK20.94037919
68PASK0.92805740
69ADRBK10.90138766
70MST1R0.87274905
71NTRK30.87193354
72ADRBK20.85395985
73BMPR20.83552501
74EPHA30.80163220
75MINK10.79782197
76NEK10.79546652
77ZAK0.77478946
78NTRK20.74778093
79CDK30.74658136
80MAP3K120.72968569
81GRK70.72555312
82STK240.72533095
83CDK190.71393239
84ERBB40.70584237
85FLT30.70308176
86AKT30.69897897
87CAMK2A0.69009653
88CSNK2A10.68386102
89CHEK20.66713559
90CDK70.65990508
91PKN10.65681574
92DAPK20.65043795
93TNIK0.65014981
94ABL20.62578180
95MAP2K40.61811058
96PDK30.60415735
97PDK40.60415735
98AURKA0.59931575
99MET0.59093770
100WNK30.58429571
101CAMKK20.57936460
102STK390.57649353
103LIMK10.57371832
104YES10.56827238
105FER0.52906565
106RPS6KB20.52661019
107FGFR20.52189419
108TLK10.51838114
109ATR0.50767504
110NLK0.50156761
111PHKG20.49448947
112PHKG10.49448947
113BRSK10.49314177
114TIE10.48511822
115PAK10.47936185
116DYRK1A0.45621616
117TSSK60.45588508
118PRKACA0.43244865
119OXSR10.43103724
120LATS10.42251071
121PDK20.40491207
122PRKCE0.40303831
123CSNK2A20.39608041
124STK30.38957563
125CSNK1G10.38825673
126PTK2B0.38705517
127FRK0.38432940
128PNCK0.38077223
129PRKACB0.37999361
130PRKG10.37571398
131CSNK1A10.37521804
132CSNK1G30.37370741
133KDR0.37324713
134TEC0.36214386
135UHMK10.34834956
136MAP2K20.34494961
137CAMK2D0.34332341
138CSNK1D0.33820331
139RAF10.33786203
140ROCK10.33729620
141CDK50.33581191
142PIK3CG0.33233577
143CAMK2B0.32299063
144ATM0.31956638
145SGK20.31214078
146SGK2230.30173414
147SGK4940.30173414

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.59292281
2RNA polymerase_Homo sapiens_hsa030203.85211067
3Proteasome_Homo sapiens_hsa030503.73871302
4Oxidative phosphorylation_Homo sapiens_hsa001903.54027154
5Parkinsons disease_Homo sapiens_hsa050123.41026246
6Protein export_Homo sapiens_hsa030603.07202568
7Nicotine addiction_Homo sapiens_hsa050332.85252082
8DNA replication_Homo sapiens_hsa030302.63923415
9Huntingtons disease_Homo sapiens_hsa050162.60655082
10Butanoate metabolism_Homo sapiens_hsa006502.50593589
11Nucleotide excision repair_Homo sapiens_hsa034202.45467028
12Mismatch repair_Homo sapiens_hsa034302.42781818
13Spliceosome_Homo sapiens_hsa030402.34835474
14Pyrimidine metabolism_Homo sapiens_hsa002402.28315317
15Basal transcription factors_Homo sapiens_hsa030222.27543062
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.25346349
17Alzheimers disease_Homo sapiens_hsa050102.19101385
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.03661762
19Homologous recombination_Homo sapiens_hsa034402.03208075
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.96242673
21RNA degradation_Homo sapiens_hsa030181.93234754
22Base excision repair_Homo sapiens_hsa034101.92358358
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.88369340
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.78507092
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.77407838
26RNA transport_Homo sapiens_hsa030131.67182029
27Taste transduction_Homo sapiens_hsa047421.66102750
28Cell cycle_Homo sapiens_hsa041101.64651419
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.57979374
30Tryptophan metabolism_Homo sapiens_hsa003801.56091412
31GABAergic synapse_Homo sapiens_hsa047271.55722966
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.55392417
33Purine metabolism_Homo sapiens_hsa002301.53739637
34Steroid biosynthesis_Homo sapiens_hsa001001.52632020
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.50487105
36Morphine addiction_Homo sapiens_hsa050321.49288256
37Fatty acid elongation_Homo sapiens_hsa000621.47185691
38Non-homologous end-joining_Homo sapiens_hsa034501.46301152
39Fanconi anemia pathway_Homo sapiens_hsa034601.43775102
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43710370
41Selenocompound metabolism_Homo sapiens_hsa004501.40781189
42SNARE interactions in vesicular transport_Homo sapiens_hsa041301.36181335
43Cardiac muscle contraction_Homo sapiens_hsa042601.35983513
44Nitrogen metabolism_Homo sapiens_hsa009101.32052896
45Olfactory transduction_Homo sapiens_hsa047401.31885630
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.31577381
47Glutamatergic synapse_Homo sapiens_hsa047241.30355178
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24686159
49Circadian entrainment_Homo sapiens_hsa047131.23857057
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19746284
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19462197
52Propanoate metabolism_Homo sapiens_hsa006401.17141245
53Folate biosynthesis_Homo sapiens_hsa007901.13502273
54Steroid hormone biosynthesis_Homo sapiens_hsa001401.10336302
55Arachidonic acid metabolism_Homo sapiens_hsa005901.05030528
56Serotonergic synapse_Homo sapiens_hsa047261.04746887
57Sulfur metabolism_Homo sapiens_hsa009201.04003475
58Collecting duct acid secretion_Homo sapiens_hsa049661.03799656
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03518695
60Sphingolipid metabolism_Homo sapiens_hsa006001.01694200
61beta-Alanine metabolism_Homo sapiens_hsa004101.00936244
62Dopaminergic synapse_Homo sapiens_hsa047281.00434402
63Caffeine metabolism_Homo sapiens_hsa002321.00124227
64Chemical carcinogenesis_Homo sapiens_hsa052040.98211191
65Vitamin B6 metabolism_Homo sapiens_hsa007500.96111784
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.95776947
67ABC transporters_Homo sapiens_hsa020100.94063325
68Glutathione metabolism_Homo sapiens_hsa004800.92226765
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90080307
70Pyruvate metabolism_Homo sapiens_hsa006200.83710530
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79217536
72Linoleic acid metabolism_Homo sapiens_hsa005910.76502153
73Metabolic pathways_Homo sapiens_hsa011000.75486982
74TGF-beta signaling pathway_Homo sapiens_hsa043500.74260775
75Insulin secretion_Homo sapiens_hsa049110.74049244
76Ether lipid metabolism_Homo sapiens_hsa005650.72263936
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71842400
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69738479
79Regulation of autophagy_Homo sapiens_hsa041400.68637484
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68222939
81p53 signaling pathway_Homo sapiens_hsa041150.65173136
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61952746
83Calcium signaling pathway_Homo sapiens_hsa040200.58733115
84Salivary secretion_Homo sapiens_hsa049700.58660495
85Epstein-Barr virus infection_Homo sapiens_hsa051690.58104336
86Synaptic vesicle cycle_Homo sapiens_hsa047210.57539585
87Cocaine addiction_Homo sapiens_hsa050300.57441167
88Amphetamine addiction_Homo sapiens_hsa050310.56974422
89Long-term depression_Homo sapiens_hsa047300.55297515
90Phototransduction_Homo sapiens_hsa047440.54718597
91Axon guidance_Homo sapiens_hsa043600.54220848
92mRNA surveillance pathway_Homo sapiens_hsa030150.53651688
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53278788
94Glycerolipid metabolism_Homo sapiens_hsa005610.52134457
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49147636
96Carbon metabolism_Homo sapiens_hsa012000.49017299
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48864655
98Autoimmune thyroid disease_Homo sapiens_hsa053200.48245235
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47966667
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46990961
101Ovarian steroidogenesis_Homo sapiens_hsa049130.46222067
102Hedgehog signaling pathway_Homo sapiens_hsa043400.45917725
103Circadian rhythm_Homo sapiens_hsa047100.44640562
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44028715
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42777582
106Cholinergic synapse_Homo sapiens_hsa047250.41904726
107Arginine and proline metabolism_Homo sapiens_hsa003300.41739461
108Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40140844
109One carbon pool by folate_Homo sapiens_hsa006700.39477338
110Basal cell carcinoma_Homo sapiens_hsa052170.39434974
111Oocyte meiosis_Homo sapiens_hsa041140.39293250
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.37183705
113Alcoholism_Homo sapiens_hsa050340.36668610
114Renin secretion_Homo sapiens_hsa049240.35441487
115Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33020142
116Maturity onset diabetes of the young_Homo sapiens_hsa049500.32120684
117Peroxisome_Homo sapiens_hsa041460.30826888
118Hippo signaling pathway_Homo sapiens_hsa043900.28542647
119Herpes simplex infection_Homo sapiens_hsa051680.28256059
120Pentose phosphate pathway_Homo sapiens_hsa000300.27525340
121Tyrosine metabolism_Homo sapiens_hsa003500.26417621
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25450149
123Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.24950532
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.24212384
125Galactose metabolism_Homo sapiens_hsa000520.24161326
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23293591
127N-Glycan biosynthesis_Homo sapiens_hsa005100.23152741
128Systemic lupus erythematosus_Homo sapiens_hsa053220.21446244
129Fatty acid metabolism_Homo sapiens_hsa012120.20274509
130Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.19769391
131Fatty acid degradation_Homo sapiens_hsa000710.19660403
132Other glycan degradation_Homo sapiens_hsa005110.18742292
133Vibrio cholerae infection_Homo sapiens_hsa051100.17396755
134Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.17172616
135Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.14242954
1362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.13234646
137Vitamin digestion and absorption_Homo sapiens_hsa049770.12928714
138Retinol metabolism_Homo sapiens_hsa008300.12846663
139Intestinal immune network for IgA production_Homo sapiens_hsa046720.12239309
140Phagosome_Homo sapiens_hsa041450.11785260
141Fructose and mannose metabolism_Homo sapiens_hsa000510.11299391
142Asthma_Homo sapiens_hsa053100.09883772
143Allograft rejection_Homo sapiens_hsa053300.09868147

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