CCDC91

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)8.87820495
2cell wall macromolecule metabolic process (GO:0044036)8.54259515
3cell wall macromolecule catabolic process (GO:0016998)8.54259515
4fusion of sperm to egg plasma membrane (GO:0007342)8.43120021
5acrosome reaction (GO:0007340)7.71667243
6sperm-egg recognition (GO:0035036)7.09012066
7acrosome assembly (GO:0001675)6.94293751
8plasma membrane fusion (GO:0045026)6.55386185
9binding of sperm to zona pellucida (GO:0007339)6.52248110
10cell-cell recognition (GO:0009988)6.30643729
11multicellular organism reproduction (GO:0032504)6.29501890
12epithelial cilium movement (GO:0003351)6.01896214
13spermatid development (GO:0007286)6.00407926
14reproduction (GO:0000003)5.79345577
15establishment of protein localization to Golgi (GO:0072600)5.53367367
16organic cation transport (GO:0015695)5.48508862
17axonemal dynein complex assembly (GO:0070286)5.24974997
18protein targeting to Golgi (GO:0000042)5.19081464
19negative regulation of inclusion body assembly (GO:0090084)5.16721936
20sperm capacitation (GO:0048240)5.05880970
21regulation of cilium movement (GO:0003352)4.93705983
22motile cilium assembly (GO:0044458)4.87322237
23retrograde transport, vesicle recycling within Golgi (GO:0000301)4.85916804
24cilium movement (GO:0003341)4.81109680
25cilium or flagellum-dependent cell motility (GO:0001539)4.58315969
26synaptonemal complex organization (GO:0070193)4.58270805
27centriole replication (GO:0007099)4.49389955
28male meiosis (GO:0007140)4.42899504
29regulation of inclusion body assembly (GO:0090083)4.42226433
30synaptonemal complex assembly (GO:0007130)4.36263346
31single fertilization (GO:0007338)4.35988083
32calcium ion-dependent exocytosis (GO:0017156)4.26587678
33amino-acid betaine transport (GO:0015838)4.26309682
34carnitine transport (GO:0015879)4.26309682
35glycerol ether metabolic process (GO:0006662)4.07322333
36positive regulation of glycolytic process (GO:0045821)4.05291607
37spermatogenesis (GO:0007283)4.03999237
38sexual reproduction (GO:0019953)4.03798481
39male gamete generation (GO:0048232)4.02150034
40protein localization to Golgi apparatus (GO:0034067)4.02052170
41carnitine transmembrane transport (GO:1902603)3.99826556
42epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.99614743
43protein polyglutamylation (GO:0018095)3.94726675
44erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.88072850
45L-phenylalanine catabolic process (GO:0006559)3.88072850
46fertilization (GO:0009566)3.80268445
47piRNA metabolic process (GO:0034587)3.79628807
48erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.73977099
49L-phenylalanine metabolic process (GO:0006558)3.73977099
50ether metabolic process (GO:0018904)3.72713270
51single strand break repair (GO:0000012)3.71638602
52response to pheromone (GO:0019236)3.71397466
53gamete generation (GO:0007276)3.67111167
54fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.65772085
55regulation of meiosis I (GO:0060631)3.65410753
56centriole assembly (GO:0098534)3.62981899
57cellular ketone body metabolic process (GO:0046950)3.51954742
58quaternary ammonium group transport (GO:0015697)3.50596958
59aspartate family amino acid catabolic process (GO:0009068)3.49035286
60carnitine shuttle (GO:0006853)3.47937868
61alpha-linolenic acid metabolic process (GO:0036109)3.42631884
62monoubiquitinated protein deubiquitination (GO:0035520)3.41044648
63lysine catabolic process (GO:0006554)3.40403112
64lysine metabolic process (GO:0006553)3.40403112
65fructose metabolic process (GO:0006000)3.39397481
66microtubule polymerization or depolymerization (GO:0031109)3.37211656
67regulation of microtubule-based movement (GO:0060632)3.34774117
68fatty acid transmembrane transport (GO:1902001)3.32753827
69lactate metabolic process (GO:0006089)3.29248904
70behavioral response to nicotine (GO:0035095)3.28582139
71macroautophagy (GO:0016236)3.26040171
72protein K63-linked deubiquitination (GO:0070536)3.25683532
73protein K48-linked deubiquitination (GO:0071108)3.24986802
74axoneme assembly (GO:0035082)3.22660445
75retinal cone cell development (GO:0046549)3.22401469
76DNA methylation involved in gamete generation (GO:0043046)3.22301697
77cellular process involved in reproduction in multicellular organism (GO:0022412)3.21861520
78tricarboxylic acid cycle (GO:0006099)3.19883849
79germ cell development (GO:0007281)3.19788998
80polyol catabolic process (GO:0046174)3.19589656
81sulfur amino acid catabolic process (GO:0000098)3.13051462
82drug transmembrane transport (GO:0006855)3.11707236
83ketone body metabolic process (GO:1902224)3.10550501
84cilium organization (GO:0044782)3.08373824
85response to mercury ion (GO:0046689)3.06228718
86spermatid nucleus differentiation (GO:0007289)3.05116257
87microtubule depolymerization (GO:0007019)3.04523715
88cilium assembly (GO:0042384)3.04335562
89protein K11-linked deubiquitination (GO:0035871)3.03247328
90primary amino compound metabolic process (GO:1901160)3.02993658
91detection of light stimulus involved in visual perception (GO:0050908)3.00659484
92detection of light stimulus involved in sensory perception (GO:0050962)3.00659484
93glycolytic process (GO:0006096)3.00220723
94serotonin metabolic process (GO:0042428)2.99565953
95alditol metabolic process (GO:0019400)2.97943032
964-hydroxyproline metabolic process (GO:0019471)2.97504296
97regulation of protein glycosylation (GO:0060049)2.96334656
98amino-acid betaine metabolic process (GO:0006577)2.94361568
99aromatic amino acid family catabolic process (GO:0009074)2.93671023
100cell recognition (GO:0008037)2.93005780
101multicellular organismal reproductive process (GO:0048609)2.92377567
102fatty acid beta-oxidation (GO:0006635)2.92216998
103photoreceptor cell maintenance (GO:0045494)2.89403190
104behavioral response to ethanol (GO:0048149)2.88518606
105positive regulation of meiosis (GO:0045836)2.88467619
106tachykinin receptor signaling pathway (GO:0007217)2.86649043
107indolalkylamine metabolic process (GO:0006586)2.86173526
108membrane depolarization during action potential (GO:0086010)2.85358917
109neural tube formation (GO:0001841)2.85299135
110regulation of establishment of cell polarity (GO:2000114)2.84522510
111fatty acid catabolic process (GO:0009062)2.84266397
112neurofilament cytoskeleton organization (GO:0060052)2.83519528
113cAMP catabolic process (GO:0006198)2.82388820
114detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.82135001
115multicellular organismal movement (GO:0050879)2.81493189
116musculoskeletal movement (GO:0050881)2.81493189
117carnitine metabolic process (GO:0009437)2.80847624
118cysteine metabolic process (GO:0006534)2.80528797
119microtubule severing (GO:0051013)2.80344752
120gamma-aminobutyric acid signaling pathway (GO:0007214)2.79663283
121glyoxylate metabolic process (GO:0046487)2.78174550
122phosphatidylethanolamine metabolic process (GO:0046337)2.75989541
123cerebellar Purkinje cell differentiation (GO:0021702)2.75733006
124urea metabolic process (GO:0019627)2.75496216
125urea cycle (GO:0000050)2.75496216
126behavioral response to cocaine (GO:0048148)2.74866410
127intra-Golgi vesicle-mediated transport (GO:0006891)2.74651865
128glycerol metabolic process (GO:0006071)2.74078929
129membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.73849494
130fatty acid oxidation (GO:0019395)2.73494596
131regulation of sarcomere organization (GO:0060297)2.73401291
132left/right axis specification (GO:0070986)2.71606497
133coenzyme catabolic process (GO:0009109)2.70827521
134cyclic nucleotide catabolic process (GO:0009214)2.70641386
135rRNA methylation (GO:0031167)2.69819394
136protein refolding (GO:0042026)2.68699206
137peptidyl-glutamic acid modification (GO:0018200)2.67781761
138Golgi to endosome transport (GO:0006895)2.67253395
139positive regulation of meiotic cell cycle (GO:0051446)2.66319767
140lipid oxidation (GO:0034440)2.65593949
141seminiferous tubule development (GO:0072520)2.64982867
142cellular component assembly involved in morphogenesis (GO:0010927)2.63003061
143monocarboxylic acid catabolic process (GO:0072329)2.60862717
144nitrogen cycle metabolic process (GO:0071941)2.60855901
145phosphatidylethanolamine biosynthetic process (GO:0006646)2.60564308
146gamma-aminobutyric acid transport (GO:0015812)2.59353180
147succinate metabolic process (GO:0006105)2.59225983
148G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.58792126
149short-chain fatty acid metabolic process (GO:0046459)2.58653367
150regulation of acrosome reaction (GO:0060046)2.58207976
151positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.58182348
152pyruvate metabolic process (GO:0006090)2.57921457
153chaperone-mediated protein complex assembly (GO:0051131)2.57305967
154male meiosis I (GO:0007141)2.56611542
155cellular carbohydrate catabolic process (GO:0044275)2.56293849
156inositol phosphate catabolic process (GO:0071545)2.55744848
157vesicle transport along microtubule (GO:0047496)2.54053585
158reflex (GO:0060004)2.52347624
159gluconeogenesis (GO:0006094)2.52278754
160signal peptide processing (GO:0006465)2.52265732
161inositol phosphate dephosphorylation (GO:0046855)2.52151600
162phosphorylated carbohydrate dephosphorylation (GO:0046838)2.52151600
1632-oxoglutarate metabolic process (GO:0006103)2.51617358
164ventricular system development (GO:0021591)2.51370533
165left/right pattern formation (GO:0060972)2.51363976
166hexose biosynthetic process (GO:0019319)2.51288974
167drug catabolic process (GO:0042737)2.51018862
168regulation of Rab GTPase activity (GO:0032313)2.50323684
169positive regulation of Rab GTPase activity (GO:0032851)2.50323684
170neuronal action potential (GO:0019228)2.50269952
171calcium ion import (GO:0070509)2.47890063

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.76060270
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.89339309
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.47414391
4GBX2_23144817_ChIP-Seq_PC3_Human3.24469413
5RXR_22158963_ChIP-Seq_LIVER_Mouse2.98902988
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.97192281
7LXR_22158963_ChIP-Seq_LIVER_Mouse2.80000285
8* PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.79292724
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.73446748
10* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.72763004
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.55465972
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.52449770
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.46321607
14IGF1R_20145208_ChIP-Seq_DFB_Human2.45934382
15EZH2_22144423_ChIP-Seq_EOC_Human2.36687773
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.34105181
17FUS_26573619_Chip-Seq_HEK293_Human2.33688282
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.32492737
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.16363584
20* P300_19829295_ChIP-Seq_ESCs_Human2.13997877
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.12835742
22* SMAD4_21799915_ChIP-Seq_A2780_Human1.99729590
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.99330495
24UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.97226285
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94083523
26* STAT3_23295773_ChIP-Seq_U87_Human1.91647604
27ER_23166858_ChIP-Seq_MCF-7_Human1.89656214
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88528243
29EGR1_23403033_ChIP-Seq_LIVER_Mouse1.85965621
30ZNF274_21170338_ChIP-Seq_K562_Hela1.83188943
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.80994236
32* TCF4_23295773_ChIP-Seq_U87_Human1.77974115
33VDR_22108803_ChIP-Seq_LS180_Human1.74973444
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.69880667
35AR_25329375_ChIP-Seq_VCAP_Human1.67999242
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.62379271
37EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.61525518
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60684984
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.59702342
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59702342
41TOP2B_26459242_ChIP-Seq_MCF-7_Human1.59085741
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.55100834
43AR_21572438_ChIP-Seq_LNCaP_Human1.54227391
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54049502
45EWS_26573619_Chip-Seq_HEK293_Human1.48914841
46TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.47190865
47ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.46904706
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.46374896
49RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.46308655
50GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.44519610
51CBP_20019798_ChIP-Seq_JUKART_Human1.43916149
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43916149
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42490542
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.42477545
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39862316
56STAT1_17558387_ChIP-Seq_HELA_Human1.39632610
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38485748
58* PRDM14_20953172_ChIP-Seq_ESCs_Human1.38275323
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37989856
60* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.37695909
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.36608799
62* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34186211
63KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33998513
64BCAT_22108803_ChIP-Seq_LS180_Human1.33654216
65PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.32368213
66* RUNX2_22187159_ChIP-Seq_PCA_Human1.31744957
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31322862
68NANOG_19829295_ChIP-Seq_ESCs_Human1.30632781
69SOX2_19829295_ChIP-Seq_ESCs_Human1.30632781
70SOX2_22085726_ChIP-Seq_NPCs_Mouse1.30278346
71TCF4_22108803_ChIP-Seq_LS180_Human1.29998085
72NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.28488163
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.28220201
74LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.27230669
75CDX2_22108803_ChIP-Seq_LS180_Human1.25086134
76RAD21_21589869_ChIP-Seq_MESCs_Mouse1.24853386
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24844532
78E2F1_18555785_Chip-Seq_ESCs_Mouse1.24831937
79* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23134780
80FLI1_21867929_ChIP-Seq_TH2_Mouse1.22932842
81KDM2B_26808549_Chip-Seq_REH_Human1.22498642
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21826351
83MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.21012436
84FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20603484
85RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20517520
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20273258
87FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20101498
88PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19444247
89ERG_20517297_ChIP-Seq_VCAP_Human1.19218896
90P53_21459846_ChIP-Seq_SAOS-2_Human1.19048741
91ELK4_26923725_Chip-Seq_MESODERM_Mouse1.18857932
92ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.18094746
93PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.16518101
94P53_22387025_ChIP-Seq_ESCs_Mouse1.16270811
95CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15921904
96FLI1_27457419_Chip-Seq_LIVER_Mouse1.15701785
97* SOX2_21211035_ChIP-Seq_LN229_Gbm1.14553411
98TBL1_22424771_ChIP-Seq_293T_Human1.14139802
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14013689
100WDR5_24793694_ChIP-Seq_LNCAP_Human1.13967548
101EP300_21415370_ChIP-Seq_HL-1_Mouse1.13756450
102* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13250633
103TAL1_26923725_Chip-Seq_HPCs_Mouse1.13007179
104* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.12214278
105ARNT_22903824_ChIP-Seq_MCF-7_Human1.10467904
106NFIB_24661679_ChIP-Seq_LUNG_Mouse1.10269482
107CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08059729
108KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07830022
109EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.07780259
110GATA3_21867929_ChIP-Seq_CD8_Mouse1.07589810
111SMAD_19615063_ChIP-ChIP_OVARY_Human1.07013085
112MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06964291
113SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06808185
114REST_21632747_ChIP-Seq_MESCs_Mouse1.05647851
115ZNF263_19887448_ChIP-Seq_K562_Human1.05561895
116STAT3_18555785_Chip-Seq_ESCs_Mouse1.04935738
117ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04885205
118OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04408435
119CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03811742
120TBX20_22328084_ChIP-Seq_HEART_Mouse1.03724191
121TBX20_22080862_ChIP-Seq_HEART_Mouse1.03724191
122ESET_19884257_ChIP-Seq_ESCs_Mouse1.03505133
123RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02976769
124GATA1_26923725_Chip-Seq_HPCs_Mouse1.02105449
125P300_18555785_Chip-Seq_ESCs_Mouse1.01496944
126SMAD4_21741376_ChIP-Seq_EPCs_Human1.01394664
127* FOXA2_19822575_ChIP-Seq_HepG2_Human1.01234230
128TP53_22573176_ChIP-Seq_HFKS_Human1.00448677
129* NFYB_21822215_ChIP-Seq_K562_Human0.99938853
130FOXA1_25329375_ChIP-Seq_VCAP_Human0.99529724
131FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99529724
132BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99471980
133ETV1_20927104_ChIP-Seq_GIST48_Human0.99349922
134CMYC_18555785_Chip-Seq_ESCs_Mouse0.98844752
135CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98579598
136FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98140279
137NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97851253
138SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96312490
139CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96284642
140CRX_20693478_ChIP-Seq_RETINA_Mouse0.95617419
141CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93956220
142RARA_24833708_ChIP-Seq_LIVER_Mouse0.93576909
143* TAF15_26573619_Chip-Seq_HEK293_Human0.93397536
144SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93257085
145SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92703598
146* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.91227929
147TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90896482
148EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90369369
149MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90184198
150CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.89814880
151MYC_27129775_Chip-Seq_CORNEA_Mouse0.89769917
152PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88263740
153GF1_26923725_Chip-Seq_HPCs_Mouse0.87168422
154CTCF_27219007_Chip-Seq_Bcells_Human0.86581609
155KAP1_22055183_ChIP-Seq_ESCs_Mouse0.86410521
156SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.86392082
157CTCF_20526341_ChIP-Seq_ESCs_Human0.86020113
158ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85585462
159HTT_18923047_ChIP-ChIP_STHdh_Human0.85452233
160GATA3_21867929_ChIP-Seq_TH1_Mouse0.84784078
161KLF4_19829295_ChIP-Seq_ESCs_Human0.84513630
162FOXH1_21741376_ChIP-Seq_ESCs_Human0.84511609
163NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.84049549
164ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.83811555
165OCT4_20526341_ChIP-Seq_ESCs_Human0.83606473
166RUNX1_26923725_Chip-Seq_HPCs_Mouse0.83480297
167AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83254707
168GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.82671654
169SOX2_21211035_ChIP-Seq_LN229_Human0.81159249
170GATA1_19941827_ChIP-Seq_MEL86_Mouse0.80895280
171SPI1_26923725_Chip-Seq_HPCs_Mouse0.80417984
172RAC3_21632823_ChIP-Seq_H3396_Human0.78617228
173ELF1_20517297_ChIP-Seq_JURKAT_Human0.78593880

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.78351098
2MP0002139_abnormal_hepatobiliary_system4.71056222
3MP0005360_urolithiasis3.76554986
4MP0000569_abnormal_digit_pigmentation3.51839259
5MP0005365_abnormal_bile_salt3.47167343
6MP0003787_abnormal_imprinting3.35877293
7MP0005085_abnormal_gallbladder_physiolo3.07907995
8MP0003698_abnormal_male_reproductive3.07870833
9MP0002837_dystrophic_cardiac_calcinosis2.83285776
10MP0008875_abnormal_xenobiotic_pharmacok2.70121255
11MP0001929_abnormal_gametogenesis2.68919764
12MP0005670_abnormal_white_adipose2.66865672
13MP0009046_muscle_twitch2.47339414
14MP0004043_abnormal_pH_regulation2.38416834
15MP0003806_abnormal_nucleotide_metabolis2.32294467
16MP0000013_abnormal_adipose_tissue2.28851369
17MP0003646_muscle_fatigue2.27577365
18MP0005551_abnormal_eye_electrophysiolog2.23270529
19MP0003252_abnormal_bile_duct2.15708216
20MP0006292_abnormal_olfactory_placode2.14084608
21MP0009745_abnormal_behavioral_response2.12986603
22MP0004145_abnormal_muscle_electrophysio2.11854079
23MP0003195_calcinosis2.06281132
24MP0010329_abnormal_lipoprotein_level1.98473714
25MP0002272_abnormal_nervous_system1.96688396
26MP0001984_abnormal_olfaction1.95573342
27MP0001485_abnormal_pinna_reflex1.95395225
28MP0005332_abnormal_amino_acid1.88069650
29MP0001486_abnormal_startle_reflex1.87173818
30MP0004036_abnormal_muscle_relaxation1.85862337
31MP0000749_muscle_degeneration1.83606560
32MP0001968_abnormal_touch/_nociception1.81962350
33MP0004130_abnormal_muscle_cell1.80615955
34MP0000751_myopathy1.79319803
35MP0001501_abnormal_sleep_pattern1.77523329
36MP0005083_abnormal_biliary_tract1.76833100
37MP0001765_abnormal_ion_homeostasis1.74122275
38MP0006276_abnormal_autonomic_nervous1.73954256
39MP0002161_abnormal_fertility/fecundity1.70372378
40MP0006036_abnormal_mitochondrial_physio1.68496085
41MP0004142_abnormal_muscle_tone1.65217660
42MP0002102_abnormal_ear_morphology1.61149336
43MP0003879_abnormal_hair_cell1.59236587
44MP0008057_abnormal_DNA_replication1.58918693
45MP0004215_abnormal_myocardial_fiber1.58644650
46MP0001666_abnormal_nutrient_absorption1.55854557
47MP0000427_abnormal_hair_cycle1.54934933
48MP0003880_abnormal_central_pattern1.54534333
49MP0003635_abnormal_synaptic_transmissio1.54494805
50MP0003718_maternal_effect1.53113462
51MP0002118_abnormal_lipid_homeostasis1.53074158
52MP0005253_abnormal_eye_physiology1.50775969
53MP0000372_irregular_coat_pigmentation1.50646016
54MP0002269_muscular_atrophy1.50249714
55MP0004233_abnormal_muscle_weight1.49241211
56MP0005636_abnormal_mineral_homeostasis1.46867683
57MP0002067_abnormal_sensory_capabilities1.46152314
58MP0002909_abnormal_adrenal_gland1.43937880
59MP0002572_abnormal_emotion/affect_behav1.42771937
60MP0002064_seizures1.42200405
61MP0005645_abnormal_hypothalamus_physiol1.39803648
62MP0005174_abnormal_tail_pigmentation1.36497480
63MP0004019_abnormal_vitamin_homeostasis1.35930698
64MP0005666_abnormal_adipose_tissue1.33304953
65MP0002736_abnormal_nociception_after1.33060315
66MP0006072_abnormal_retinal_apoptosis1.32094323
67MP0002735_abnormal_chemical_nociception1.30765066
68MP0002229_neurodegeneration1.30478500
69MP0001970_abnormal_pain_threshold1.30402570
70MP0002210_abnormal_sex_determination1.30276647
71MP0002078_abnormal_glucose_homeostasis1.28825387
72MP0009643_abnormal_urine_homeostasis1.26989297
73MP0004859_abnormal_synaptic_plasticity1.26720604
74MP0010234_abnormal_vibrissa_follicle1.25006788
75MP0003329_amyloid_beta_deposits1.24562877
76MP0002733_abnormal_thermal_nociception1.23805568
77MP0005319_abnormal_enzyme/_coenzyme1.23701586
78MP0003121_genomic_imprinting1.22623962
79MP0000747_muscle_weakness1.22544061
80MP0002557_abnormal_social/conspecific_i1.22191708
81MP0004270_analgesia1.20944070
82MP0009780_abnormal_chondrocyte_physiolo1.20858873
83MP0005377_hearing/vestibular/ear_phenot1.19669588
84MP0003878_abnormal_ear_physiology1.19669588
85MP0002063_abnormal_learning/memory/cond1.18797185
86MP0001145_abnormal_male_reproductive1.17353483
87MP0002971_abnormal_brown_adipose1.15110983
88MP0001440_abnormal_grooming_behavior1.15097096
89MP0000003_abnormal_adipose_tissue1.14817599
90MP0002734_abnormal_mechanical_nocicepti1.14675022
91MP0008877_abnormal_DNA_methylation1.14474945
92MP0005375_adipose_tissue_phenotype1.14174025
93MP0008872_abnormal_physiological_respon1.14095065
94MP0001905_abnormal_dopamine_level1.13156408
95MP0005386_behavior/neurological_phenoty1.12792996
96MP0004924_abnormal_behavior1.12792996
97MP0000609_abnormal_liver_physiology1.10526084
98MP0005310_abnormal_salivary_gland1.08308160
99MP0002877_abnormal_melanocyte_morpholog1.07822417
100MP0002106_abnormal_muscle_physiology1.06932716
101MP0005584_abnormal_enzyme/coenzyme_acti1.06905680
102MP0004742_abnormal_vestibular_system1.06843565
103MP0004147_increased_porphyrin_level1.06772257
104MP0000653_abnormal_sex_gland1.06148417
105MP0004087_abnormal_muscle_fiber1.05716422
106MP0009840_abnormal_foam_cell1.05620655
107MP0004484_altered_response_of1.04283419
108MP0002095_abnormal_skin_pigmentation1.04186668
109MP0002693_abnormal_pancreas_physiology1.02761510
110MP0004085_abnormal_heartbeat1.01678056
111MP0000759_abnormal_skeletal_muscle1.01604801
112MP0003890_abnormal_embryonic-extraembry1.01495947
113MP0005620_abnormal_muscle_contractility1.01480379
114MP0005266_abnormal_metabolism1.00986934
115MP0001944_abnormal_pancreas_morphology0.99021573
116MP0005379_endocrine/exocrine_gland_phen0.98926479
117MP0005389_reproductive_system_phenotype0.98520082
118MP0005075_abnormal_melanosome_morpholog0.96123703
119MP0002638_abnormal_pupillary_reflex0.93974917
120MP0003136_yellow_coat_color0.93972583
121MP0002138_abnormal_hepatobiliary_system0.92313355
122MP0005535_abnormal_body_temperature0.91819009
123MP0002332_abnormal_exercise_endurance0.91587145
124MP0000015_abnormal_ear_pigmentation0.90902314
125MP0005369_muscle_phenotype0.90167680
126MP0005423_abnormal_somatic_nervous0.90023061
127MP0001963_abnormal_hearing_physiology0.89912416
128MP0008961_abnormal_basal_metabolism0.88560916
129MP0008569_lethality_at_weaning0.87942888
130MP0004885_abnormal_endolymph0.87291997
131MP0003631_nervous_system_phenotype0.86458292
132MP0009697_abnormal_copulation0.85848552
133MP0003191_abnormal_cellular_cholesterol0.85780834
134MP0001756_abnormal_urination0.84722169
135MP0000631_abnormal_neuroendocrine_gland0.84656848
136MP0004084_abnormal_cardiac_muscle0.84209249
137MP0001764_abnormal_homeostasis0.82544515
138MP0000678_abnormal_parathyroid_gland0.82145073
139MP0001986_abnormal_taste_sensitivity0.81825765
140MP0005647_abnormal_sex_gland0.81758723
141MP0000604_amyloidosis0.79371048
142MP0002234_abnormal_pharynx_morphology0.79209766
143MP0000955_abnormal_spinal_cord0.77623106
144MP0010386_abnormal_urinary_bladder0.77287041
145MP0003045_fibrosis0.77177121
146MP0003953_abnormal_hormone_level0.74176207
147MP0006035_abnormal_mitochondrial_morpho0.74051364
148MP0003959_abnormal_lean_body0.73935317
149MP0005220_abnormal_exocrine_pancreas0.73192163
150MP0003705_abnormal_hypodermis_morpholog0.70090205
151MP0002108_abnormal_muscle_morphology0.69307939
152MP0005334_abnormal_fat_pad0.68848807
153MP0002822_catalepsy0.68452828
154MP0003183_abnormal_peptide_metabolism0.68063411
155MP0002160_abnormal_reproductive_system0.67801572
156MP0000750_abnormal_muscle_regeneration0.67541655
157MP0000538_abnormal_urinary_bladder0.66282428
158MP0001661_extended_life_span0.66244150
159MP0002928_abnormal_bile_duct0.65373857
160MP0002295_abnormal_pulmonary_circulatio0.65368287
161MP0003868_abnormal_feces_composition0.64610693
162MP0002876_abnormal_thyroid_physiology0.62860239
163MP0005646_abnormal_pituitary_gland0.62847791
164MP0000230_abnormal_systemic_arterial0.62238739
165MP0003633_abnormal_nervous_system0.61841987
166MP0002653_abnormal_ependyma_morphology0.61740591
167MP0009642_abnormal_blood_homeostasis0.60793151
168MP0002896_abnormal_bone_mineralization0.60375601
169MP0005330_cardiomyopathy0.59400687
170MP0005275_abnormal_skin_tensile0.56734845
171MP0003221_abnormal_cardiomyocyte_apopto0.54599929
172MP0003283_abnormal_digestive_organ0.53431818

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)7.18044407
2Absent/shortened dynein arms (HP:0200106)7.18044407
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.92180389
4Abnormal respiratory motile cilium physiology (HP:0012261)4.96641637
5Chronic bronchitis (HP:0004469)4.61835869
6Abnormal respiratory epithelium morphology (HP:0012253)4.61568668
7Abnormal respiratory motile cilium morphology (HP:0005938)4.61568668
8Chronic hepatic failure (HP:0100626)4.46795485
9Infertility (HP:0000789)4.38683300
10Myoglobinuria (HP:0002913)4.10283617
11Exercise-induced myalgia (HP:0003738)4.06133532
12Pancreatic fibrosis (HP:0100732)4.02894314
13Progressive cerebellar ataxia (HP:0002073)3.81528065
14Abnormal ciliary motility (HP:0012262)3.75366471
15Rhinitis (HP:0012384)3.74768863
16Pancreatic cysts (HP:0001737)3.73433349
17Abnormality of the renal cortex (HP:0011035)3.62158669
18Gaze-evoked nystagmus (HP:0000640)3.55578221
19Gout (HP:0001997)3.53888217
20Abnormal gallbladder physiology (HP:0012438)3.48216494
21Cholecystitis (HP:0001082)3.48216494
22True hermaphroditism (HP:0010459)3.45797799
23Ketosis (HP:0001946)3.36448774
24Nasal polyposis (HP:0100582)3.36420086
25Exercise-induced muscle cramps (HP:0003710)3.35798680
26Abnormality of aromatic amino acid family metabolism (HP:0004338)3.29940004
27Male infertility (HP:0003251)3.28365165
28Abnormality of midbrain morphology (HP:0002418)3.25391093
29Molar tooth sign on MRI (HP:0002419)3.25391093
30Ketoacidosis (HP:0001993)3.20544865
31Metaphyseal dysplasia (HP:0100255)3.15072629
32Febrile seizures (HP:0002373)3.10674296
33Genetic anticipation (HP:0003743)3.08988398
34Rhabdomyolysis (HP:0003201)2.95947875
35Attenuation of retinal blood vessels (HP:0007843)2.94750269
36Medial flaring of the eyebrow (HP:0010747)2.93757568
37Asymmetric septal hypertrophy (HP:0001670)2.87360465
38Abnormality of the nasal mucosa (HP:0000433)2.86911358
39Hypoglycemic coma (HP:0001325)2.79292088
40Volvulus (HP:0002580)2.72885264
41Hyporeflexia of lower limbs (HP:0002600)2.71493852
42Hypobetalipoproteinemia (HP:0003563)2.70095697
43Abnormality of purine metabolism (HP:0004352)2.68588224
44Hyperinsulinemic hypoglycemia (HP:0000825)2.67444332
45Hyperuricemia (HP:0002149)2.66262853
46Increased purine levels (HP:0004368)2.66262853
47Intrahepatic cholestasis (HP:0001406)2.59078139
48Severe visual impairment (HP:0001141)2.50578398
49Dialeptic seizures (HP:0011146)2.49521035
50Bony spicule pigmentary retinopathy (HP:0007737)2.49429940
51Generalized aminoaciduria (HP:0002909)2.49338111
52Muscle fiber inclusion bodies (HP:0100299)2.48659992
53Difficulty running (HP:0009046)2.47745299
54Renal cortical cysts (HP:0000803)2.45495044
55Deep venous thrombosis (HP:0002625)2.42669384
56Xanthomatosis (HP:0000991)2.42519363
57Abnormal rod and cone electroretinograms (HP:0008323)2.41205121
58Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.34935645
59Muscle hypertrophy of the lower extremities (HP:0008968)2.34809156
60Hypolipoproteinemia (HP:0010981)2.34793523
61Abnormality of fatty-acid metabolism (HP:0004359)2.31918844
62Cystic liver disease (HP:0006706)2.31639452
63Hyperkalemia (HP:0002153)2.30409373
64Focal motor seizures (HP:0011153)2.29855495
65Absence seizures (HP:0002121)2.29132969
66Hyperammonemia (HP:0001987)2.29014394
67Atonic seizures (HP:0010819)2.28907169
68Ulnar deviation of the wrist (HP:0003049)2.28717956
69Congenital hepatic fibrosis (HP:0002612)2.28130089
70Late onset (HP:0003584)2.27631704
71Hyperventilation (HP:0002883)2.27474157
72Nephronophthisis (HP:0000090)2.25934420
73Truncal obesity (HP:0001956)2.24770201
74Congenital stationary night blindness (HP:0007642)2.24240299
75Abnormality of monocarboxylic acid metabolism (HP:0010996)2.23832273
76Abnormal drinking behavior (HP:0030082)2.23553753
77Polydipsia (HP:0001959)2.23553753
78Bronchitis (HP:0012387)2.22395284
79Gait imbalance (HP:0002141)2.21604002
80Aplasia/Hypoplasia of the tongue (HP:0010295)2.21518535
81Hypoalphalipoproteinemia (HP:0003233)2.20197163
82Focal seizures (HP:0007359)2.18981713
83Distal arthrogryposis (HP:0005684)2.18571858
84Congenital primary aphakia (HP:0007707)2.18144415
85Type 1 muscle fiber predominance (HP:0003803)2.16742366
86Calf muscle hypertrophy (HP:0008981)2.16547020
87Hypothermia (HP:0002045)2.15773822
88Abnormality of renal excretion (HP:0011036)2.15061904
89Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.13174449
90Bundle branch block (HP:0011710)2.12298721
91Abnormality of macular pigmentation (HP:0008002)2.12250663
92Bronchiectasis (HP:0002110)2.12180884
93Central scotoma (HP:0000603)2.10612425
94Muscle fiber splitting (HP:0003555)2.09580187
95Abnormal spermatogenesis (HP:0008669)2.09405891
96Nephrogenic diabetes insipidus (HP:0009806)2.06689596
97Postural instability (HP:0002172)2.06007321
98Abnormal urine output (HP:0012590)2.04894620
99Insulin-resistant diabetes mellitus (HP:0000831)2.03776284
100Muscle stiffness (HP:0003552)2.03697981
101Papillary thyroid carcinoma (HP:0002895)2.03516652
102Congenital sensorineural hearing impairment (HP:0008527)2.03259457
103Nemaline bodies (HP:0003798)2.01994855
104Hyperglycinuria (HP:0003108)2.01180291
105Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.98622316
106Tubulointerstitial abnormality (HP:0001969)1.98532400
107Tubulointerstitial nephritis (HP:0001970)1.98343603
108Degeneration of the lateral corticospinal tracts (HP:0002314)1.95602164
109Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.95602164
110Absent speech (HP:0001344)1.95423529
111Hyperglycemia (HP:0003074)1.95368624
112Furrowed tongue (HP:0000221)1.94623678
113Tubulointerstitial fibrosis (HP:0005576)1.94549990
114Genital tract atresia (HP:0001827)1.94486219
115Bile duct proliferation (HP:0001408)1.94455537
116Abnormal biliary tract physiology (HP:0012439)1.94455537
117Abnormality of the intrinsic pathway (HP:0010989)1.94327888
118Fair hair (HP:0002286)1.93210268
119Abnormal gallbladder morphology (HP:0012437)1.92296269
120Thyroid-stimulating hormone excess (HP:0002925)1.91988875
121Hypoglycemic seizures (HP:0002173)1.91660403
122Sclerocornea (HP:0000647)1.91380815
123Palpitations (HP:0001962)1.91202768
124Abnormality of serine family amino acid metabolism (HP:0010894)1.90830838
125Abnormality of glycine metabolism (HP:0010895)1.90830838
126Occipital encephalocele (HP:0002085)1.90718627
127Myopathic facies (HP:0002058)1.90334770
128Difficulty climbing stairs (HP:0003551)1.90109047
129Hyperglycinemia (HP:0002154)1.89060663
130Abnormality of glutamine family amino acid metabolism (HP:0010902)1.86301088
131Aplasia/Hypoplasia of the tibia (HP:0005772)1.85994370
132Menstrual irregularities (HP:0000858)1.85188618
133Global brain atrophy (HP:0002283)1.85095491
134Postaxial foot polydactyly (HP:0001830)1.84081949
135EMG: neuropathic changes (HP:0003445)1.83903175
136Optic nerve hypoplasia (HP:0000609)1.83035114
137Hypercholesterolemia (HP:0003124)1.82798915
138Cholelithiasis (HP:0001081)1.82309227
139Widely spaced teeth (HP:0000687)1.82293209
140Polyuria (HP:0000103)1.82032013
141Type II lissencephaly (HP:0007260)1.81973534
142Progressive macrocephaly (HP:0004481)1.81538775
143Oligomenorrhea (HP:0000876)1.81386682
144Broad-based gait (HP:0002136)1.81060487
145Abnormality of nucleobase metabolism (HP:0010932)1.81026155
146Thyroiditis (HP:0100646)1.80016387
147Male pseudohermaphroditism (HP:0000037)1.79813752
148Cone-rod dystrophy (HP:0000548)1.79525738
149Spastic tetraparesis (HP:0001285)1.77823765
150Complement deficiency (HP:0004431)1.77812464
151Tubular atrophy (HP:0000092)1.76864198
152Portal hypertension (HP:0001409)1.76596900
153Amelogenesis imperfecta (HP:0000705)1.76514598
154Abnormality of potassium homeostasis (HP:0011042)1.76348719
155Abnormality of the renal medulla (HP:0100957)1.75806661
156Abolished electroretinogram (ERG) (HP:0000550)1.74357902
157Vascular calcification (HP:0004934)1.74291968
158Epidermoid cyst (HP:0200040)1.74147190
159Generalized muscle weakness (HP:0003324)1.73908063
160Myokymia (HP:0002411)1.73275264
161Hypokalemic alkalosis (HP:0001949)1.72930704
162Abnormality of the corticospinal tract (HP:0002492)1.72382312
163Abnormality of dicarboxylic acid metabolism (HP:0010995)1.71293135
164Dicarboxylic aciduria (HP:0003215)1.71293135
165Symptomatic seizures (HP:0011145)1.70406899
166Poor coordination (HP:0002370)1.70180485
167Vaginal atresia (HP:0000148)1.69798187
168Neurofibrillary tangles (HP:0002185)1.69649340
169Fatigable weakness (HP:0003473)1.68495542
170Increased CSF lactate (HP:0002490)1.65824173
171Stage 5 chronic kidney disease (HP:0003774)1.65602288
172Acute necrotizing encephalopathy (HP:0006965)1.64941695
173Neoplasm of the adrenal cortex (HP:0100641)1.64110118
174Constricted visual fields (HP:0001133)1.63255093
175Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.60895419
176Abnormality of alanine metabolism (HP:0010916)1.60895419
177Hyperalaninemia (HP:0003348)1.60895419
178Scotoma (HP:0000575)1.60779210
179Mitochondrial inheritance (HP:0001427)1.60622921

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.07216402
2PDK47.07216402
3PDK24.54242201
4TESK14.23874913
5PRKD34.15844294
6WNK42.70514667
7ICK2.49770933
8MAP4K22.41005253
9PLK42.29653806
10BCKDK2.20987811
11NUAK12.06378620
12FRK1.83924034
13PLK21.82959458
14ZAK1.79708408
15STK391.79535033
16MST41.69370988
17TXK1.61655874
18OBSCN1.61123567
19PTK2B1.54430230
20RIPK11.50791233
21CASK1.48862860
22TTN1.47481100
23ADRBK21.43127027
24PIK3CG1.39264016
25INSRR1.38289241
26DYRK1B1.37114043
27TEC1.33103588
28MAPK131.29876610
29PHKG21.29810330
30PHKG11.29810330
31PINK11.27072862
32STK381.25131893
33BMPR21.16505513
34PDK11.14724678
35LMTK21.11019134
36MAP2K41.10680533
37NLK1.08037745
38TRIB31.07199209
39GRK51.06882408
40GRK11.05650689
41CDK191.04345526
42AKT31.01424799
43MAP3K40.98933834
44NEK10.97863012
45MAP2K70.96192065
46PDPK10.95831656
47KSR20.95757808
48MAP3K20.93186892
49PKN20.91990390
50TNIK0.91340594
51TRPM70.88400183
52MAP2K60.86578123
53ERBB30.84196892
54MAP3K90.81592318
55OXSR10.81254873
56EPHA40.79981665
57PRKCE0.79074190
58CAMK2A0.78645169
59ERN10.77336670
60WNK10.75129710
61MAPK150.73802521
62CSNK1G20.71382242
63STK38L0.71148234
64MUSK0.70260486
65DAPK20.69501534
66MST1R0.69066626
67TRIM280.68745854
68PIK3CA0.68710527
69CSNK1G10.67844435
70CAMK10.67698551
71WNK30.67640851
72BRD40.67524970
73PRKG10.65367744
74PNCK0.64766564
75PRKAA10.63213374
76MYLK0.62969917
77ADRBK10.62857978
78MARK10.60915795
79PASK0.60100433
80NME10.60044669
81CSNK1A1L0.59134770
82PAK60.58942896
83FER0.56904344
84MKNK20.56672071
85MAP3K10.56237101
86SGK10.55429852
87BRSK20.54932708
88PKN10.54689713
89FGFR20.54608942
90MAPKAPK50.54336117
91CSNK1D0.52592098
92ITK0.52509592
93FLT30.52291305
94BRAF0.52095614
95CAMKK20.51802452
96PRKCQ0.51448373
97RET0.50335734
98NEK90.49957800
99SGK2230.49930379
100SGK4940.49930379
101SIK10.49472220
102CSNK1G30.49080116
103IRAK10.48522280
104PRKACA0.47044703
105TNK20.46725555
106STK110.46684162
107BMPR1B0.46634785
108PTK60.45632637
109PRKACB0.45282538
110CAMK1G0.44657086
111PTK20.44388698
112ERBB40.44083878
113MAP2K10.42925545
114PAK30.42911818
115CAMK40.42431235
116NTRK10.42416740
117GRK70.42047452
118MAPKAPK30.40491348
119MAP3K120.39942530
120CAMK2D0.39697548
121CAMKK10.38987178
122MINK10.38259473
123NEK60.38000128
124CAMK2G0.37947608
125CDK50.37776181
126CDK30.37771151
127LATS10.36790073
128SYK0.36644243
129TIE10.36281776
130ARAF0.36153964
131LATS20.35935853
132VRK10.35600961
133FGFR40.35511443
134SGK30.34803301
135DMPK0.34500413
136CSNK1E0.34216158
137MARK20.34196110
138PRKAA20.33159506
139EIF2AK30.33080684
140RPS6KA30.33048375
141ACVR1B0.32335796
142EEF2K0.31080264
143IRAK20.30674919
144MAP2K30.29938520
145NTRK30.29191669
146MAP3K70.29070388
147PDGFRA0.28989280
148MET0.28937025
149TAOK10.28292371
150MTOR0.28045364
151SGK20.25321086
152PRKCG0.24904207
153PAK20.23315268
154MAP3K30.23264408
155PRKG20.22732652
156SCYL20.22437092
157PRKACG0.21809299
158NEK20.21802553
159STK30.20857906
160EPHB10.20635969
161TAOK30.20246753

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.22095367
2Propanoate metabolism_Homo sapiens_hsa006403.17974023
3Phototransduction_Homo sapiens_hsa047443.00390560
4Pyruvate metabolism_Homo sapiens_hsa006202.85342928
5Fatty acid degradation_Homo sapiens_hsa000712.84329388
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.70655406
7Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.64655803
8Olfactory transduction_Homo sapiens_hsa047402.48947703
9Morphine addiction_Homo sapiens_hsa050322.35184472
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.26393493
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.26041265
12Fatty acid metabolism_Homo sapiens_hsa012122.22124900
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.18339242
14Sulfur metabolism_Homo sapiens_hsa009202.12559794
15Primary bile acid biosynthesis_Homo sapiens_hsa001202.11213473
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.09317618
17Taste transduction_Homo sapiens_hsa047422.01091058
18Dorso-ventral axis formation_Homo sapiens_hsa043202.00251209
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.98724829
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.98246228
21GABAergic synapse_Homo sapiens_hsa047271.98168704
22Circadian entrainment_Homo sapiens_hsa047131.96698509
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.95888177
24PPAR signaling pathway_Homo sapiens_hsa033201.94936439
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.94407425
26Nitrogen metabolism_Homo sapiens_hsa009101.88535398
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.87640377
28Butanoate metabolism_Homo sapiens_hsa006501.86680651
29Carbon metabolism_Homo sapiens_hsa012001.85626417
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.76508227
31Tryptophan metabolism_Homo sapiens_hsa003801.74343793
32Fatty acid biosynthesis_Homo sapiens_hsa000611.73144951
33Salivary secretion_Homo sapiens_hsa049701.65027696
34Glutamatergic synapse_Homo sapiens_hsa047241.63015363
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.62624167
36Glucagon signaling pathway_Homo sapiens_hsa049221.61670085
37Selenocompound metabolism_Homo sapiens_hsa004501.60915085
38Serotonergic synapse_Homo sapiens_hsa047261.56568428
39Basal transcription factors_Homo sapiens_hsa030221.53577156
40Calcium signaling pathway_Homo sapiens_hsa040201.49898166
41Arginine biosynthesis_Homo sapiens_hsa002201.42924826
42Pentose and glucuronate interconversions_Homo sapiens_hsa000401.41834580
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40475674
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.39923036
45Peroxisome_Homo sapiens_hsa041461.38318143
46Fat digestion and absorption_Homo sapiens_hsa049751.37804465
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.36899505
48Fructose and mannose metabolism_Homo sapiens_hsa000511.35912211
49Bile secretion_Homo sapiens_hsa049761.34598321
50Carbohydrate digestion and absorption_Homo sapiens_hsa049731.32552276
51Regulation of autophagy_Homo sapiens_hsa041401.31707213
52Vitamin B6 metabolism_Homo sapiens_hsa007501.29839172
53Glycerolipid metabolism_Homo sapiens_hsa005611.28312038
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.27282622
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23921128
56Chemical carcinogenesis_Homo sapiens_hsa052041.23412406
57Starch and sucrose metabolism_Homo sapiens_hsa005001.23406481
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20184679
59Biosynthesis of amino acids_Homo sapiens_hsa012301.19508717
60Vascular smooth muscle contraction_Homo sapiens_hsa042701.19152504
61Homologous recombination_Homo sapiens_hsa034401.18972869
62beta-Alanine metabolism_Homo sapiens_hsa004101.16156812
63Dopaminergic synapse_Homo sapiens_hsa047281.15566038
64Cholinergic synapse_Homo sapiens_hsa047251.15091157
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.12201062
66Oxytocin signaling pathway_Homo sapiens_hsa049211.10281489
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08881887
68Long-term depression_Homo sapiens_hsa047301.08614106
69SNARE interactions in vesicular transport_Homo sapiens_hsa041301.06790444
70Phenylalanine metabolism_Homo sapiens_hsa003601.06775447
71Cysteine and methionine metabolism_Homo sapiens_hsa002701.05962380
72Huntingtons disease_Homo sapiens_hsa050161.03217582
73cAMP signaling pathway_Homo sapiens_hsa040241.00782564
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99559913
75Tyrosine metabolism_Homo sapiens_hsa003500.99201729
76Ether lipid metabolism_Homo sapiens_hsa005650.99012623
77Insulin secretion_Homo sapiens_hsa049110.97266258
78Fatty acid elongation_Homo sapiens_hsa000620.96946387
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95888853
80Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94228082
81Linoleic acid metabolism_Homo sapiens_hsa005910.93809548
82Histidine metabolism_Homo sapiens_hsa003400.93709440
83Fanconi anemia pathway_Homo sapiens_hsa034600.93048087
84Pentose phosphate pathway_Homo sapiens_hsa000300.91257052
85Complement and coagulation cascades_Homo sapiens_hsa046100.86866188
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.84795736
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.79765899
88Insulin resistance_Homo sapiens_hsa049310.78923570
89Long-term potentiation_Homo sapiens_hsa047200.77186066
90Collecting duct acid secretion_Homo sapiens_hsa049660.76779495
91Parkinsons disease_Homo sapiens_hsa050120.76095956
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75767555
93ABC transporters_Homo sapiens_hsa020100.74797419
94Glutathione metabolism_Homo sapiens_hsa004800.73795438
95Cardiac muscle contraction_Homo sapiens_hsa042600.73015509
96AMPK signaling pathway_Homo sapiens_hsa041520.72893183
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72494217
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72466567
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72297774
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.71237968
101Inositol phosphate metabolism_Homo sapiens_hsa005620.70513340
102Arginine and proline metabolism_Homo sapiens_hsa003300.68866898
103Purine metabolism_Homo sapiens_hsa002300.68429212
104Alzheimers disease_Homo sapiens_hsa050100.67386562
105RNA polymerase_Homo sapiens_hsa030200.67076523
106Oocyte meiosis_Homo sapiens_hsa041140.66687646
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66096468
108Alcoholism_Homo sapiens_hsa050340.66065440
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65776489
110Platelet activation_Homo sapiens_hsa046110.64103060
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62169450
112Galactose metabolism_Homo sapiens_hsa000520.61656948
113Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61314721
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60881060
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.60288892
116Retinol metabolism_Homo sapiens_hsa008300.58978169
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58641354
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57024894
119Synaptic vesicle cycle_Homo sapiens_hsa047210.56451666
120Steroid hormone biosynthesis_Homo sapiens_hsa001400.55138531
121Insulin signaling pathway_Homo sapiens_hsa049100.54910407
122Folate biosynthesis_Homo sapiens_hsa007900.54908331
123Caffeine metabolism_Homo sapiens_hsa002320.54764258
124Type II diabetes mellitus_Homo sapiens_hsa049300.53145475
125Thyroid hormone synthesis_Homo sapiens_hsa049180.51909239
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.50733682
127Amphetamine addiction_Homo sapiens_hsa050310.49613739
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49387663
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48559496
130RNA degradation_Homo sapiens_hsa030180.48220921
131Metabolic pathways_Homo sapiens_hsa011000.47321169
132Ovarian steroidogenesis_Homo sapiens_hsa049130.47230863
133Cyanoamino acid metabolism_Homo sapiens_hsa004600.46971396
134Vibrio cholerae infection_Homo sapiens_hsa051100.43678796
135Drug metabolism - other enzymes_Homo sapiens_hsa009830.43604048
136Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43566710
137Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42378247
138Non-homologous end-joining_Homo sapiens_hsa034500.42353751
139Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42285504
140Mineral absorption_Homo sapiens_hsa049780.40097721
141Glycosaminoglycan degradation_Homo sapiens_hsa005310.39003077
142Protein digestion and absorption_Homo sapiens_hsa049740.37576806
143Pancreatic secretion_Homo sapiens_hsa049720.36773218
144Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.36494126
145Type I diabetes mellitus_Homo sapiens_hsa049400.34764801
146Steroid biosynthesis_Homo sapiens_hsa001000.34245071
147Gastric acid secretion_Homo sapiens_hsa049710.32819593
148Systemic lupus erythematosus_Homo sapiens_hsa053220.32774504
149Protein export_Homo sapiens_hsa030600.31012065
150cGMP-PKG signaling pathway_Homo sapiens_hsa040220.29612958
151Lysine degradation_Homo sapiens_hsa003100.29583069
152Renin secretion_Homo sapiens_hsa049240.29183630
153Circadian rhythm_Homo sapiens_hsa047100.26393500
154Oxidative phosphorylation_Homo sapiens_hsa001900.25157204

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