CCDC93

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.09173751
2positive regulation by organism of defense response of other organism involved in symbiotic interact5.09173751
3modulation by symbiont of host immune response (GO:0052553)5.09173751
4positive regulation by symbiont of host defense response (GO:0052509)5.09173751
5modulation by symbiont of host defense response (GO:0052031)5.09173751
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.09173751
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.77509422
8regulation of interferon-beta biosynthetic process (GO:0045357)4.45875109
9regulation of integrin activation (GO:0033623)4.12810525
10macrophage activation involved in immune response (GO:0002281)4.10453338
11positive regulation of gamma-delta T cell activation (GO:0046645)3.92890321
12cellular extravasation (GO:0045123)3.88605056
13I-kappaB phosphorylation (GO:0007252)3.88597701
14cellular response to ethanol (GO:0071361)3.72618547
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.59772986
16negative regulation of cell killing (GO:0031342)3.59772986
17histone H3-K9 demethylation (GO:0033169)3.50726767
18microglial cell activation (GO:0001774)3.49880634
19negative regulation of granulocyte differentiation (GO:0030853)3.47011917
20positive regulation of interferon-alpha production (GO:0032727)3.37069620
21detection of molecule of bacterial origin (GO:0032490)3.31090710
22daunorubicin metabolic process (GO:0044597)3.27605411
23polyketide metabolic process (GO:0030638)3.27605411
24doxorubicin metabolic process (GO:0044598)3.27605411
25regulation of interferon-alpha production (GO:0032647)3.15269647
26regulation of B cell receptor signaling pathway (GO:0050855)3.15089475
27response to host immune response (GO:0052572)3.14900354
28response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.14900354
29positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.08025137
30mannose metabolic process (GO:0006013)3.02437726
31response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.00826074
32response to host (GO:0075136)3.00826074
33response to host defenses (GO:0052200)3.00826074
34oligosaccharide catabolic process (GO:0009313)3.00511988
35macrophage activation (GO:0042116)2.95434375
36positive regulation of interferon-beta production (GO:0032728)2.93676155
37NLS-bearing protein import into nucleus (GO:0006607)2.93673179
38regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.89950035
39histone H3-K36 demethylation (GO:0070544)2.89468452
40macroautophagy (GO:0016236)2.89206547
41histone lysine demethylation (GO:0070076)2.89117132
42regulation of gamma-delta T cell activation (GO:0046643)2.87195266
43negative regulation of interleukin-12 production (GO:0032695)2.86635177
44substrate-dependent cell migration (GO:0006929)2.86551107
45interleukin-6-mediated signaling pathway (GO:0070102)2.85990687
46pinocytosis (GO:0006907)2.85671430
47positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.85277468
48histone demethylation (GO:0016577)2.84789671
49positive thymic T cell selection (GO:0045059)2.83779567
50glycosphingolipid catabolic process (GO:0046479)2.82770236
51regulation of gamma-delta T cell differentiation (GO:0045586)2.82298626
52positive regulation of chemokine secretion (GO:0090197)2.81617802
53regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.78968236
54coronary vasculature morphogenesis (GO:0060977)2.78912795
55cell adhesion mediated by integrin (GO:0033627)2.77761314
56regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.77066363
57positive regulation of SMAD protein import into nucleus (GO:0060391)2.75231553
58response to peptidoglycan (GO:0032494)2.72790661
59plasma lipoprotein particle assembly (GO:0034377)2.72681595
60response to laminar fluid shear stress (GO:0034616)2.69583633
61embryonic retina morphogenesis in camera-type eye (GO:0060059)2.69384986
62positive regulation of p38MAPK cascade (GO:1900745)2.69365386
63regulation of mononuclear cell migration (GO:0071675)2.68593532
64negative regulation of translation, ncRNA-mediated (GO:0040033)2.68498717
65regulation of translation, ncRNA-mediated (GO:0045974)2.68498717
66negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.68498717
67protein-lipid complex assembly (GO:0065005)2.67619271
68phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.67049981
69modulation by symbiont of host cellular process (GO:0044068)2.65819949
70B cell homeostasis (GO:0001782)2.64731294
71regulation of chemokine secretion (GO:0090196)2.64058752
72G-protein coupled receptor internalization (GO:0002031)2.63726395
73wound healing, spreading of epidermal cells (GO:0035313)2.63407711
74regulation of interferon-beta production (GO:0032648)2.60978145
75positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.59048986
76regulation of NFAT protein import into nucleus (GO:0051532)2.55914673
77regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.53607035
78skin morphogenesis (GO:0043589)2.53046791
79protein localization to endosome (GO:0036010)2.53023535
80positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.52676611
81positive regulation of extracellular matrix organization (GO:1903055)2.52221839
82regulation of apoptotic cell clearance (GO:2000425)2.51716017
83nerve growth factor signaling pathway (GO:0038180)2.51233396
84protein dealkylation (GO:0008214)2.51141020
85protein demethylation (GO:0006482)2.51141020
86pore complex assembly (GO:0046931)2.49480962
87myeloid cell activation involved in immune response (GO:0002275)2.48202496
88very-low-density lipoprotein particle assembly (GO:0034379)2.48076243
89fibroblast migration (GO:0010761)2.47270357
90apoptotic cell clearance (GO:0043277)2.47061152
91response to lipoprotein particle (GO:0055094)2.46224808
92glycolipid catabolic process (GO:0019377)2.45752676
93response to muramyl dipeptide (GO:0032495)2.44889886
94monocyte chemotaxis (GO:0002548)2.42867625
95positive T cell selection (GO:0043368)2.42824518
96regulation of interleukin-12 biosynthetic process (GO:0045075)2.42125689
97peptide catabolic process (GO:0043171)2.41879712
98regulation of macrophage chemotaxis (GO:0010758)2.41171645
99positive regulation of cellular amide metabolic process (GO:0034250)2.40995664
100regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.39958541
101regulation of membrane protein ectodomain proteolysis (GO:0051043)2.39659573
102positive regulation of interleukin-1 beta secretion (GO:0050718)2.39496828
103Golgi to endosome transport (GO:0006895)2.39438987
104negative regulation of B cell proliferation (GO:0030889)2.38632394
105positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.38383349
106detection of biotic stimulus (GO:0009595)2.38371628
107regulation of RNA export from nucleus (GO:0046831)2.37429963
108pre-miRNA processing (GO:0031054)2.36507283
109negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.34416353
110cholesterol efflux (GO:0033344)2.32124352
111plasma membrane repair (GO:0001778)2.30126609
112nuclear pore complex assembly (GO:0051292)2.29677941
113positive regulation of antigen processing and presentation (GO:0002579)2.27015074
114mature B cell differentiation (GO:0002335)2.26169369
115detection of external biotic stimulus (GO:0098581)2.25637397
116platelet-derived growth factor receptor signaling pathway (GO:0048008)2.25397863
117germinal center formation (GO:0002467)2.24026956
118establishment of nucleus localization (GO:0040023)2.23971613
119cellular response to thyroid hormone stimulus (GO:0097067)2.23313544
120regulation of SMAD protein import into nucleus (GO:0060390)2.22531208
121positive regulation of receptor recycling (GO:0001921)2.22467344
122immunoglobulin mediated immune response (GO:0016064)2.21081218
123regulation of Cdc42 GTPase activity (GO:0043088)2.20968993
124intestinal epithelial cell development (GO:0060576)2.20619937
125lipopolysaccharide-mediated signaling pathway (GO:0031663)2.20378684
126regulation of T-helper 2 cell differentiation (GO:0045628)2.20152033
127negative regulation of stress fiber assembly (GO:0051497)2.19859364
128modification by symbiont of host morphology or physiology (GO:0044003)2.19111099
129negative regulation of macroautophagy (GO:0016242)2.18460587
130negative regulation of bone resorption (GO:0045779)2.16085021
131ruffle organization (GO:0031529)2.15545608
132positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.14566534
133natural killer cell mediated cytotoxicity (GO:0042267)2.14393119
134natural killer cell mediated immunity (GO:0002228)2.14393119
135regulation of nucleobase-containing compound transport (GO:0032239)2.14255756
136positive regulation of interleukin-1 secretion (GO:0050716)2.14207962
137venous blood vessel morphogenesis (GO:0048845)2.13178731
138histone mRNA catabolic process (GO:0071044)2.12990305
139cellular response to interferon-alpha (GO:0035457)2.12695387
140striated muscle atrophy (GO:0014891)2.11840988
141axon extension involved in axon guidance (GO:0048846)2.11783349
142neuron projection extension involved in neuron projection guidance (GO:1902284)2.11783349
143monoubiquitinated protein deubiquitination (GO:0035520)2.11560802
144negative regulation of protein activation cascade (GO:2000258)2.11438191
145positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.09935698
146negative regulation of complement activation (GO:0045916)2.09612140
147regulation of extracellular matrix organization (GO:1903053)2.08852791
148retrograde transport, vesicle recycling within Golgi (GO:0000301)2.07490068
149negative regulation of anoikis (GO:2000811)2.07308424
150myeloid dendritic cell differentiation (GO:0043011)2.07181449
151T-helper 1 type immune response (GO:0042088)2.07093133
152embryonic process involved in female pregnancy (GO:0060136)2.06639716
153response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.06251020
154negative regulation of fatty acid biosynthetic process (GO:0045717)2.05376872
155positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.04917279
156COPII vesicle coating (GO:0048208)2.03743940
157dicarboxylic acid biosynthetic process (GO:0043650)2.03737392
158ceramide catabolic process (GO:0046514)2.02236128
159protein targeting to vacuole (GO:0006623)1.99926905
160protein targeting to lysosome (GO:0006622)1.99926905
161establishment of protein localization to vacuole (GO:0072666)1.99926905
162osteoclast differentiation (GO:0030316)1.97841399
163negative regulation of humoral immune response (GO:0002921)1.96810493
164regulation of T cell tolerance induction (GO:0002664)1.96746399
165skeletal muscle adaptation (GO:0043501)1.95564223
166histone H3-K4 trimethylation (GO:0080182)1.95481668
167cellular response to nerve growth factor stimulus (GO:1990090)1.95195711
168response to nerve growth factor (GO:1990089)1.95195711
169neutrophil activation involved in immune response (GO:0002283)1.94971552
170regulation of tolerance induction (GO:0002643)1.94537425
171mRNA modification (GO:0016556)1.94027439
172regulation of necroptotic process (GO:0060544)1.93838828
173Rap protein signal transduction (GO:0032486)1.92183916
174interkinetic nuclear migration (GO:0022027)1.91964874
175regulation of histone H3-K27 methylation (GO:0061085)1.90686354
176protein targeting to Golgi (GO:0000042)1.88443533
177negative regulation of potassium ion transmembrane transporter activity (GO:1901017)1.87736993

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.66234220
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.64384550
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.53972027
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.53718189
5E2F7_22180533_ChIP-Seq_HELA_Human3.36323946
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.36179797
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.25602773
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.21375238
9* IRF8_27001747_Chip-Seq_BMDM_Mouse3.19606191
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.03757814
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.02523012
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.95499805
13* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.74232031
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.73784169
15VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.65057047
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.51637658
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.42642685
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.38048213
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.23995777
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.21483451
21WT1_19549856_ChIP-ChIP_CCG9911_Human2.16420984
22SPI1_23127762_ChIP-Seq_K562_Human2.11936186
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.06894526
24STAT6_21828071_ChIP-Seq_BEAS2B_Human2.03371806
25SMAD_19615063_ChIP-ChIP_OVARY_Human2.00849114
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.88766854
27RUNX_20019798_ChIP-Seq_JUKART_Human1.86349086
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.83760403
29PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.83183317
30EP300_21415370_ChIP-Seq_HL-1_Mouse1.76212055
31* FOXA2_19822575_ChIP-Seq_HepG2_Human1.75936520
32VDR_21846776_ChIP-Seq_THP-1_Human1.72937304
33MYC_22102868_ChIP-Seq_BL_Human1.70977779
34BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.64956497
35NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.63814251
36NRF2_20460467_ChIP-Seq_MEFs_Mouse1.63814251
37ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.59324234
38SCL_19346495_ChIP-Seq_HPC-7_Human1.59083683
39TCF7_22412390_ChIP-Seq_EML_Mouse1.58095608
40TP53_16413492_ChIP-PET_HCT116_Human1.52229688
41* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.46766824
42NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.45386054
43TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.44457979
44* PU_27001747_Chip-Seq_BMDM_Mouse1.40279024
45BRD4_25478319_ChIP-Seq_HGPS_Human1.39741561
46NFIB_24661679_ChIP-Seq_LUNG_Mouse1.39598329
47MYB_26560356_Chip-Seq_TH1_Human1.38839657
48ESR1_21235772_ChIP-Seq_MCF-7_Human1.38496205
49* VDR_24787735_ChIP-Seq_THP-1_Human1.36909626
50FOXO3_23340844_ChIP-Seq_DLD1_Human1.36708318
51KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.36301818
52CDX2_20551321_ChIP-Seq_CACO-2_Human1.36240332
53* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35308738
54RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.34290353
55CLOCK_20551151_ChIP-Seq_293T_Human1.33767991
56PPAR_26484153_Chip-Seq_NCI-H1993_Human1.32993973
57GATA2_21666600_ChIP-Seq_HMVEC_Human1.32064852
58MYB_26560356_Chip-Seq_TH2_Human1.31559186
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31103511
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.30763844
61SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.30090635
62SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.30090635
63VDR_24763502_ChIP-Seq_THP-1_Human1.29652789
64TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29459140
65KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.27509547
66FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27362760
67AHR_22903824_ChIP-Seq_MCF-7_Human1.25825328
68PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25571561
69SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24975297
70ESR1_20079471_ChIP-ChIP_T-47D_Human1.23291397
71CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22897550
72MAF_26560356_Chip-Seq_TH1_Human1.22784718
73SPI1_23547873_ChIP-Seq_NB4_Human1.19727889
74TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19553481
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18596972
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18372081
77EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.18167356
78UTX_26944678_Chip-Seq_JUKART_Human1.17767057
79E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.17545461
80KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14695916
81LXR_22158963_ChIP-Seq_LIVER_Mouse1.13943929
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.12999779
83* TBX20_22328084_ChIP-Seq_HEART_Mouse1.12811593
84* TBX20_22080862_ChIP-Seq_HEART_Mouse1.12811593
85CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11870115
86KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11531300
87CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.11348993
88RXR_22108803_ChIP-Seq_LS180_Human1.10688437
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10095241
90RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.10056250
91TP63_23658742_ChIP-Seq_EP156T_Human1.10014206
92TP53_18474530_ChIP-ChIP_U2OS_Human1.09730686
93PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09432603
94RUNX1_22412390_ChIP-Seq_EML_Mouse1.09352373
95IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.09174033
96SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08648724
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07814501
98GATA6_25053715_ChIP-Seq_YYC3_Human1.06498283
99KDM2B_26808549_Chip-Seq_DND41_Human1.06091572
100RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05533315
101STAT3_23295773_ChIP-Seq_U87_Human1.05489004
102SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05023636
103CJUN_26792858_Chip-Seq_BT549_Human1.03824943
104CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03188726
105* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02574761
106ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02255218
107FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.02089080
108FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01697019
109PIAS1_25552417_ChIP-Seq_VCAP_Human1.01384623
110SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00458803
111MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99196643
112TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98830986
113STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98737004
114OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98577952
115SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98483285
116TCF4_18268006_ChIP-ChIP_LS174T_Human0.98139680
117TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98129486
118ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97320678
119BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97200336
120* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96806284
121KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96728673
122YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96653221
123KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96651000
124POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96609290
125EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96576839
126P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95359781
127DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94851236
128WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94727407
129ESR2_21235772_ChIP-Seq_MCF-7_Human0.93165481
130GATA3_27048872_Chip-Seq_THYMUS_Human0.92936510
131* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92563808
132SMAD3_21741376_ChIP-Seq_HESCs_Human0.91631821
133* SMAD4_21799915_ChIP-Seq_A2780_Human0.91509420
134NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91196210
135ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90546926
136TRIM28_21343339_ChIP-Seq_HEK293_Human0.89361160
137* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.89101433
138ELK3_25401928_ChIP-Seq_HUVEC_Human0.88754484
139GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88158202
140SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.88087435
141SOX2_20726797_ChIP-Seq_SW620_Human0.88048460
142STAT4_19710469_ChIP-ChIP_TH1__Mouse0.87305544
143NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.87107752
144* NANOG_18555785_Chip-Seq_ESCs_Mouse0.86899181
145JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86864365
146SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.86563908
147GATA2_19941826_ChIP-Seq_K562_Human0.82520233
148GATA1_19941827_ChIP-Seq_MEL_Mouse0.81470486

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.98093277
2MP0003172_abnormal_lysosome_physiology3.44942712
3MP0002396_abnormal_hematopoietic_system2.89086413
4MP0006054_spinal_hemorrhage2.78143399
5MP0005058_abnormal_lysosome_morphology2.59911194
6MP0003300_gastrointestinal_ulcer2.49042243
7MP0003566_abnormal_cell_adhesion2.47345375
8MP0003705_abnormal_hypodermis_morpholog2.46051475
9MP0010352_gastrointestinal_tract_polyps2.18203552
10MP0008260_abnormal_autophagy2.16163823
11MP0003693_abnormal_embryo_hatching2.14416935
12MP0005076_abnormal_cell_differentiation2.11308347
13MP0003303_peritoneal_inflammation2.07233463
14MP0002877_abnormal_melanocyte_morpholog2.07080361
15MP0003656_abnormal_erythrocyte_physiolo2.06823700
16MP0005451_abnormal_body_composition2.02933298
17MP0010307_abnormal_tumor_latency2.01444491
18MP0001835_abnormal_antigen_presentation1.96007466
19MP0002139_abnormal_hepatobiliary_system1.87837818
20MP0000604_amyloidosis1.86999685
21MP0003221_abnormal_cardiomyocyte_apopto1.84370078
22MP0002419_abnormal_innate_immunity1.82715176
23MP0005671_abnormal_response_to1.82542263
24MP0006082_CNS_inflammation1.77985974
25MP0005257_abnormal_intraocular_pressure1.77425432
26MP0003690_abnormal_glial_cell1.77217595
27MP0001849_ear_inflammation1.75744539
28MP0003828_pulmonary_edema1.72982933
29MP0008438_abnormal_cutaneous_collagen1.70092604
30MP0001800_abnormal_humoral_immune1.68309984
31MP0000015_abnormal_ear_pigmentation1.67478147
32MP0002452_abnormal_antigen_presenting1.66876677
33MP0004947_skin_inflammation1.66317552
34MP0003091_abnormal_cell_migration1.63770068
35MP0000371_diluted_coat_color1.57698504
36MP0000490_abnormal_crypts_of1.53850039
37MP0004185_abnormal_adipocyte_glucose1.52466057
38MP0005174_abnormal_tail_pigmentation1.50113190
39MP0002998_abnormal_bone_remodeling1.48822393
40MP0003436_decreased_susceptibility_to1.47676830
41MP0003195_calcinosis1.47551155
42MP0002332_abnormal_exercise_endurance1.47522218
43MP0010234_abnormal_vibrissa_follicle1.47361739
44MP0005248_abnormal_Harderian_gland1.46594228
45MP0004808_abnormal_hematopoietic_stem1.45053599
46MP0003045_fibrosis1.43266049
47MP0005023_abnormal_wound_healing1.42131401
48MP0003878_abnormal_ear_physiology1.41980855
49MP0005377_hearing/vestibular/ear_phenot1.41980855
50MP0005464_abnormal_platelet_physiology1.41817883
51MP0003329_amyloid_beta_deposits1.41163257
52MP0003111_abnormal_nucleus_morphology1.39970164
53MP0000343_altered_response_to1.38384156
54MP0003950_abnormal_plasma_membrane1.37172723
55MP0002837_dystrophic_cardiac_calcinosis1.36517781
56MP0002723_abnormal_immune_serum1.35828539
57MP0001819_abnormal_immune_cell1.34326842
58MP0009278_abnormal_bone_marrow1.34204532
59MP0005000_abnormal_immune_tolerance1.32131228
60MP0002420_abnormal_adaptive_immunity1.30979385
61MP0000733_abnormal_muscle_development1.30515260
62MP0005409_darkened_coat_color1.27822312
63MP0004233_abnormal_muscle_weight1.27751210
64MP0001790_abnormal_immune_system1.27444492
65MP0005387_immune_system_phenotype1.27444492
66MP0010155_abnormal_intestine_physiology1.24644902
67MP0003890_abnormal_embryonic-extraembry1.24565172
68MP0005670_abnormal_white_adipose1.23793397
69MP0005025_abnormal_response_to1.19196108
70MP0000767_abnormal_smooth_muscle1.18200020
71MP0002166_altered_tumor_susceptibility1.16296573
72MP0004084_abnormal_cardiac_muscle1.14409813
73MP0002896_abnormal_bone_mineralization1.12774661
74MP0002006_tumorigenesis1.11874797
75MP0004036_abnormal_muscle_relaxation1.09580544
76MP0002398_abnormal_bone_marrow1.09306355
77MP0000920_abnormal_myelination1.08733187
78MP0004215_abnormal_myocardial_fiber1.08295326
79MP0003724_increased_susceptibility_to1.08245067
80MP0002168_other_aberrant_phenotype1.07532349
81MP0001533_abnormal_skeleton_physiology1.06316874
82MP0000383_abnormal_hair_follicle1.05903938
83MP0005164_abnormal_response_to1.05480459
84MP0002148_abnormal_hypersensitivity_rea1.05330171
85MP0003868_abnormal_feces_composition1.04697783
86MP0009780_abnormal_chondrocyte_physiolo1.04219632
87MP0009697_abnormal_copulation1.04165819
88MP0003448_altered_tumor_morphology1.03985733
89MP0003634_abnormal_glial_cell1.03952652
90MP0004510_myositis1.03105275
91MP0000716_abnormal_immune_system1.00829659
92MP0008004_abnormal_stomach_pH0.99681415
93MP0002405_respiratory_system_inflammati0.99125070
94MP0009840_abnormal_foam_cell0.98497793
95MP0003191_abnormal_cellular_cholesterol0.98394007
96MP0010678_abnormal_skin_adnexa0.98383079
97MP0002972_abnormal_cardiac_muscle0.97750760
98MP0001958_emphysema0.97520150
99MP0002971_abnormal_brown_adipose0.95172267
100MP0003122_maternal_imprinting0.95167765
101MP0004130_abnormal_muscle_cell0.94879701
102MP0003279_aneurysm0.94465993
103MP0000703_abnormal_thymus_morphology0.94364804
104MP0005666_abnormal_adipose_tissue0.93493163
105MP0002928_abnormal_bile_duct0.93277342
106MP0002722_abnormal_immune_system0.93039018
107MP0002009_preneoplasia0.93004214
108MP0004272_abnormal_basement_membrane0.93000963
109MP0000689_abnormal_spleen_morphology0.92847584
110MP0005330_cardiomyopathy0.92749280
111MP0001845_abnormal_inflammatory_respons0.91633396
112MP0001545_abnormal_hematopoietic_system0.91553973
113MP0005397_hematopoietic_system_phenotyp0.91553973
114MP0003252_abnormal_bile_duct0.89236364
115MP0009384_cardiac_valve_regurgitation0.88274887
116MP0002060_abnormal_skin_morphology0.86918608
117MP0001915_intracranial_hemorrhage0.86314369
118MP0004264_abnormal_extraembryonic_tissu0.85916256
119MP0010094_abnormal_chromosome_stability0.85764370
120MP0000750_abnormal_muscle_regeneration0.85390356
121MP0009785_altered_susceptibility_to0.85165510
122MP0003453_abnormal_keratinocyte_physiol0.84946194
123MP0000858_altered_metastatic_potential0.84598927
124MP0006138_congestive_heart_failure0.84526191
125MP0004087_abnormal_muscle_fiber0.84251192
126MP0002429_abnormal_blood_cell0.83304609
127MP0003984_embryonic_growth_retardation0.82459431
128MP0002088_abnormal_embryonic_growth/wei0.81961086
129MP0010368_abnormal_lymphatic_system0.81472271
130MP0002075_abnormal_coat/hair_pigmentati0.80245937
131MP0009115_abnormal_fat_cell0.80200137
132MP0003183_abnormal_peptide_metabolism0.80007696
133MP0000685_abnormal_immune_system0.79761454
134MP0002086_abnormal_extraembryonic_tissu0.78438099
135MP0002269_muscular_atrophy0.78268253
136MP0005310_abnormal_salivary_gland0.76679193
137MP0004883_abnormal_blood_vessel0.76209089
138MP0001672_abnormal_embryogenesis/_devel0.76057462
139MP0005380_embryogenesis_phenotype0.76057462
140MP0003941_abnormal_skin_development0.73339420
141MP0003632_abnormal_nervous_system0.72888308
142MP0005621_abnormal_cell_physiology0.71227504
143MP0004484_altered_response_of0.71036406
144MP0000249_abnormal_blood_vessel0.70843479
145MP0005197_abnormal_uvea_morphology0.70786665
146MP0005375_adipose_tissue_phenotype0.69776700
147MP0010630_abnormal_cardiac_muscle0.69570923
148MP0002925_abnormal_cardiovascular_devel0.68868390

Predicted human phenotypes

RankGene SetZ-score
1Urethral obstruction (HP:0000796)3.95470960
2Cerebral aneurysm (HP:0004944)3.38074961
3Systemic lupus erythematosus (HP:0002725)3.33361265
4Recurrent abscess formation (HP:0002722)3.08050494
5Aortic aneurysm (HP:0004942)3.05213981
6Abnormality of macrophages (HP:0004311)2.87361333
7Prostate neoplasm (HP:0100787)2.83901563
8Papillary thyroid carcinoma (HP:0002895)2.83851181
9Neurofibrillary tangles (HP:0002185)2.80676252
10Chronic diarrhea (HP:0002028)2.77250280
11Abnormality of liposaccharide metabolism (HP:0010968)2.75376861
12Abnormality of glycosphingolipid metabolism (HP:0004343)2.75376861
13Abnormality of glycolipid metabolism (HP:0010969)2.75376861
14Hematochezia (HP:0002573)2.73234221
15Recurrent fungal infections (HP:0002841)2.71909232
16Cheilitis (HP:0100825)2.70574117
17Eczematoid dermatitis (HP:0000976)2.69689363
18Loss of speech (HP:0002371)2.67115888
19Cervical subluxation (HP:0003308)2.66874215
20Recurrent bacterial skin infections (HP:0005406)2.64072643
21Increased cerebral lipofuscin (HP:0011813)2.63855970
22Pustule (HP:0200039)2.59888189
23Global brain atrophy (HP:0002283)2.58655822
24Abnormality of the fingertips (HP:0001211)2.56904648
25Periodontitis (HP:0000704)2.55560462
26Alopecia of scalp (HP:0002293)2.54376256
27Autoimmune thrombocytopenia (HP:0001973)2.50898640
28Heterotopia (HP:0002282)2.45248834
29Disinhibition (HP:0000734)2.44096168
30Gingivitis (HP:0000230)2.43315099
31Recurrent cutaneous fungal infections (HP:0011370)2.41661743
32Chronic mucocutaneous candidiasis (HP:0002728)2.41661743
33Mitral stenosis (HP:0001718)2.39443036
34Apathy (HP:0000741)2.31304824
35Premature loss of primary teeth (HP:0006323)2.27351102
36Thyroiditis (HP:0100646)2.25881579
37Eosinophilia (HP:0001880)2.25751125
38Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.25434317
39Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.25348690
40Peritonitis (HP:0002586)2.23032724
41Thick nail (HP:0001805)2.21492804
42Mitral valve prolapse (HP:0001634)2.19476563
43Abnormality of mucopolysaccharide metabolism (HP:0011020)2.16220081
44Abnormality of polysaccharide metabolism (HP:0011012)2.16220081
45Abnormality of glycosaminoglycan metabolism (HP:0004371)2.16220081
46Increased neuronal autofluorescent lipopigment (HP:0002074)2.16095543
47Osteolytic defects of the hand bones (HP:0009699)2.16019098
48Osteolytic defects of the phalanges of the hand (HP:0009771)2.16019098
49Cerebral inclusion bodies (HP:0100314)2.14427427
50Oligodontia (HP:0000677)2.12178456
51Deep venous thrombosis (HP:0002625)2.10543183
52Bilateral sensorineural hearing impairment (HP:0008619)2.10038013
53Recurrent viral infections (HP:0004429)2.09109523
54Shallow orbits (HP:0000586)2.08295682
55Absent frontal sinuses (HP:0002688)2.07474412
56Arterial tortuosity (HP:0005116)2.07089893
57Spondylolisthesis (HP:0003302)2.04946739
58Abnormality of eosinophils (HP:0001879)2.03980372
59Aortic dissection (HP:0002647)1.99143027
60Glomerulonephritis (HP:0000099)1.98205464
61Bone pain (HP:0002653)1.97017257
62Abnormality of the ischium (HP:0003174)1.96907633
63Diminished motivation (HP:0000745)1.94869880
64Broad palm (HP:0001169)1.92918276
65Subacute progressive viral hepatitis (HP:0006572)1.92533806
66Protuberant abdomen (HP:0001538)1.92401309
67Frequent falls (HP:0002359)1.91692671
68Narrow palate (HP:0000189)1.90859481
69Myocardial infarction (HP:0001658)1.90791249
70T lymphocytopenia (HP:0005403)1.90370092
71Spinal cord lesions (HP:0100561)1.89995565
72Syringomyelia (HP:0003396)1.89995565
73Increased connective tissue (HP:0009025)1.88996669
74Leukocytosis (HP:0001974)1.88822611
75Prominent nose (HP:0000448)1.88536290
76Tetraparesis (HP:0002273)1.88399651
77Premature rupture of membranes (HP:0001788)1.88041751
78Asymmetric septal hypertrophy (HP:0001670)1.87547728
79Combined immunodeficiency (HP:0005387)1.86995605
80Dilatation of the ascending aorta (HP:0005111)1.86018365
81Vascular tortuosity (HP:0004948)1.85458899
82Aneurysm (HP:0002617)1.85121631
83Epidermoid cyst (HP:0200040)1.83622348
84Flat acetabular roof (HP:0003180)1.82840960
85Severe combined immunodeficiency (HP:0004430)1.82616665
86Abnormal foot bone ossification (HP:0010675)1.82606055
87Transitional cell carcinoma of the bladder (HP:0006740)1.81635943
88Recurrent skin infections (HP:0001581)1.81452108
89Vertebral arch anomaly (HP:0008438)1.79675255
90Disproportionate tall stature (HP:0001519)1.79567737
91Distal lower limb amyotrophy (HP:0008944)1.79426435
92Hypoplasia of the thymus (HP:0000778)1.79200977
93Retrobulbar optic neuritis (HP:0100654)1.78087045
94Optic neuritis (HP:0100653)1.78087045
95Urinary glycosaminoglycan excretion (HP:0003541)1.77326358
96Mucopolysacchariduria (HP:0008155)1.77326358
97Skin nodule (HP:0200036)1.76757779
98Dysostosis multiplex (HP:0000943)1.76352200
99Anal stenosis (HP:0002025)1.75678657
100Coarse hair (HP:0002208)1.75499310
101Widely spaced teeth (HP:0000687)1.74347656
102Neurodegeneration (HP:0002180)1.73512743
103Esophageal varix (HP:0002040)1.72868162
104Sparse lateral eyebrow (HP:0005338)1.72857821
105Neuronal loss in central nervous system (HP:0002529)1.72646901
106Termporal pattern (HP:0011008)1.72349904
107Insidious onset (HP:0003587)1.72349904
108Complement deficiency (HP:0004431)1.71710817
109Macroorchidism (HP:0000053)1.71659747
110Abnormality of T cell number (HP:0011839)1.71470726
111Genu recurvatum (HP:0002816)1.71166443
112Amyloidosis (HP:0011034)1.71041760
113Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.70924318
114Persistence of primary teeth (HP:0006335)1.69768653
115Tibial bowing (HP:0002982)1.69148259
116Colitis (HP:0002583)1.68700780
117Low anterior hairline (HP:0000294)1.68063028
118Agnosia (HP:0010524)1.68033482
119Supranuclear gaze palsy (HP:0000605)1.67860100
120Recurrent gram-negative bacterial infections (HP:0005420)1.67467034
121Increased density of long bones (HP:0006392)1.67328064
122Bladder carcinoma (HP:0002862)1.67217631
123Bladder neoplasm (HP:0009725)1.67217631
124Orchitis (HP:0100796)1.66660741
125Vacuolated lymphocytes (HP:0001922)1.66177155
126Nephritis (HP:0000123)1.65763118
127Ectopic kidney (HP:0000086)1.64769488
128Large earlobe (HP:0009748)1.64487889
129Cupped ribs (HP:0000887)1.64362424
130Tapered finger (HP:0001182)1.63879443
131Hyperacusis (HP:0010780)1.63419048
132Atrophic scars (HP:0001075)1.62363300
133Granulocytopenia (HP:0001913)1.61111985
134Long eyelashes (HP:0000527)1.60639797
135Open mouth (HP:0000194)1.60057291
136Ulnar bowing (HP:0003031)1.59823909
137Elfin facies (HP:0004428)1.59774669
138Wide nose (HP:0000445)1.59460916
139Renal cell carcinoma (HP:0005584)1.58991940
140Leiomyosarcoma (HP:0100243)1.58675148
141Uterine leiomyosarcoma (HP:0002891)1.58675148
142Neonatal short-limb short stature (HP:0008921)1.58439023
143Increased CSF protein (HP:0002922)1.57989967
144Inappropriate behavior (HP:0000719)1.57888574
145Thin bony cortex (HP:0002753)1.57732800
146Pathologic fracture (HP:0002756)1.57650784
147Chromsome breakage (HP:0040012)1.57306714
148Viral hepatitis (HP:0006562)1.56684978
149Hypoplastic ischia (HP:0003175)1.55986810
150Neoplasm of the tracheobronchial system (HP:0100552)1.55627109
151Broad face (HP:0000283)1.55492643
152Scanning speech (HP:0002168)1.54971403
153Osteomyelitis (HP:0002754)1.54439409
154Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.54185441
155Reduced subcutaneous adipose tissue (HP:0003758)1.53428487
156Gastrointestinal infarctions (HP:0005244)1.52620794
157Right ventricular cardiomyopathy (HP:0011663)1.52418203
158Dislocated radial head (HP:0003083)1.52354350
159Truncal obesity (HP:0001956)1.52135809
160Thickened calvaria (HP:0002684)1.52066654
161Axonal loss (HP:0003447)1.52055413
162Mitral regurgitation (HP:0001653)1.52029471
163Nuclear cataract (HP:0100018)1.51415499
164Onion bulb formation (HP:0003383)1.50701420
165Abnormality of the frontal sinuses (HP:0002687)1.50401316

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.60425460
2CAMK1D3.48272003
3TGFBR23.01019651
4CAMK1G2.63193849
5SIK22.56760263
6DDR22.53348819
7TTN2.21820895
8STK102.19205798
9SIK11.99796861
10TYK21.89853970
11PDGFRA1.88149290
12JAK11.86748268
13LATS11.83725619
14KSR11.78027932
15YES11.69099946
16MAP3K131.67543741
17MAP3K141.67487798
18MAP4K11.64463422
19CSF1R1.62550206
20KSR21.59003157
21STK31.50790738
22MAP3K101.42639984
23RIPK41.41637814
24CASK1.40890143
25MARK31.39239159
26RIPK11.34378755
27MAP3K31.32579080
28IRAK11.29100181
29MAP3K91.24113782
30NEK91.24098659
31EEF2K1.23740890
32PDGFRB1.23667672
33AKT31.23041475
34TXK1.22833923
35MAP2K31.21898369
36BLK1.21673173
37TAOK31.21632485
38MAP3K61.19797014
39PKN21.18964225
40TTK1.18857969
41HCK1.18248121
42PTK61.17043905
43CSK1.15657971
44EPHB11.15655896
45ERBB31.15109984
46STK241.14026261
47NEK21.13393892
48TRIB31.13241039
49IRAK31.12993142
50MST1R1.12393676
51BRD41.12120209
52STK38L1.10978779
53MAP3K21.10326452
54EPHA21.06796988
55MATK1.06516938
56TRPM71.06188256
57ALK1.05771888
58MAP3K71.03801032
59SGK31.03618153
60TNIK1.01930004
61PRPF4B1.01633400
62BCR1.01180223
63RET1.00387707
64IRAK20.99875198
65MOS0.97902034
66FGR0.97631077
67ERN10.97576132
68EIF2AK20.97542247
69ZAP700.97315729
70CAMKK20.97156157
71TAOK10.96108154
72TBK10.93586283
73MTOR0.93225896
74NLK0.91996002
75PAK40.91738438
76MAP3K40.89967702
77JAK30.88647744
78KIT0.86551050
79MAP3K10.85879664
80FGFR30.84732276
81SIK30.84353380
82GRK70.83582404
83ERBB40.82678875
84RPS6KA40.81696772
85MAP3K80.80968377
86FGFR20.80559134
87EPHA30.79731014
88PIK3CA0.79680808
89CDK60.79072605
90IKBKB0.78577409
91CHUK0.77042721
92PRKAA20.74849395
93ZAK0.74033377
94MARK20.71569116
95IRAK40.71443564
96ITK0.70939358
97STK40.70850491
98NUAK10.70386983
99PAK20.69604719
100SGK20.67406255
101SCYL20.65211051
102ROCK10.65174544
103CDC42BPA0.63442847
104PNCK0.63438308
105FGFR10.60370016
106LCK0.60137947
107FGFR40.59797397
108ROCK20.58688665
109ACVR1B0.58483115
110ATR0.58222831
111CAMK40.57834728
112MAPK110.56607484
113PIM10.55802001
114IKBKE0.54138814
115PDK10.51697785
116DMPK0.51680290
117WNK10.50825398
118RAF10.50524387
119PDPK10.50318937
120LYN0.49582871
121PRKAA10.49490979
122EGFR0.49411984
123ICK0.49285912
124INSRR0.48525289
125STK380.48478829
126MELK0.46540582
127SGK10.45781458
128FER0.45698445
129AKT20.45110465
130SYK0.43854647
131CLK10.43202016
132MAPK100.43037184
133JAK20.42939050
134IGF1R0.42220285
135TYRO30.41996570
136MARK10.40024949
137MAP3K50.39301801
138MAPK120.38905501
139BMX0.38129057

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.18611860
2Staphylococcus aureus infection_Homo sapiens_hsa051502.13176646
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.06525996
4Glycosaminoglycan degradation_Homo sapiens_hsa005311.94952210
5NF-kappa B signaling pathway_Homo sapiens_hsa040641.80570096
6Toll-like receptor signaling pathway_Homo sapiens_hsa046201.76939195
7Leishmaniasis_Homo sapiens_hsa051401.68121402
8B cell receptor signaling pathway_Homo sapiens_hsa046621.66538369
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.59909142
10Chronic myeloid leukemia_Homo sapiens_hsa052201.52732128
11Complement and coagulation cascades_Homo sapiens_hsa046101.51235161
12Tuberculosis_Homo sapiens_hsa051521.47721120
13Measles_Homo sapiens_hsa051621.44115756
14Lysosome_Homo sapiens_hsa041421.43615038
15Other glycan degradation_Homo sapiens_hsa005111.42593038
16Adherens junction_Homo sapiens_hsa045201.40819437
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.40219448
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.36626782
19Influenza A_Homo sapiens_hsa051641.35982724
20Primary immunodeficiency_Homo sapiens_hsa053401.35789328
21Hematopoietic cell lineage_Homo sapiens_hsa046401.34488399
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.34157805
23Toxoplasmosis_Homo sapiens_hsa051451.31652759
24Renal cell carcinoma_Homo sapiens_hsa052111.30618731
25Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28596552
26Lysine degradation_Homo sapiens_hsa003101.28594876
27Type II diabetes mellitus_Homo sapiens_hsa049301.28562635
28mTOR signaling pathway_Homo sapiens_hsa041501.24162870
29Apoptosis_Homo sapiens_hsa042101.22396725
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.21721598
31Small cell lung cancer_Homo sapiens_hsa052221.21287471
32TNF signaling pathway_Homo sapiens_hsa046681.19297513
33Hepatitis B_Homo sapiens_hsa051611.16075911
34Antigen processing and presentation_Homo sapiens_hsa046121.15023450
35Pancreatic cancer_Homo sapiens_hsa052121.13198036
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.12190702
37MicroRNAs in cancer_Homo sapiens_hsa052061.11923868
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.11195462
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.10734720
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10629725
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09906454
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09870826
43Choline metabolism in cancer_Homo sapiens_hsa052311.07547371
44Circadian rhythm_Homo sapiens_hsa047101.05680074
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04283136
46T cell receptor signaling pathway_Homo sapiens_hsa046601.03861412
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.02013221
48Acute myeloid leukemia_Homo sapiens_hsa052211.01203689
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99108290
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.98173283
51Proteoglycans in cancer_Homo sapiens_hsa052050.98157357
52GnRH signaling pathway_Homo sapiens_hsa049120.94456466
53Malaria_Homo sapiens_hsa051440.93959478
54Inositol phosphate metabolism_Homo sapiens_hsa005620.93096097
55Viral myocarditis_Homo sapiens_hsa054160.92806325
56ErbB signaling pathway_Homo sapiens_hsa040120.91793311
57Prion diseases_Homo sapiens_hsa050200.91709707
58Herpes simplex infection_Homo sapiens_hsa051680.91169419
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.91126667
60Pertussis_Homo sapiens_hsa051330.90783532
61Chemokine signaling pathway_Homo sapiens_hsa040620.89999189
62Legionellosis_Homo sapiens_hsa051340.88012524
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87225974
64HTLV-I infection_Homo sapiens_hsa051660.86849323
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86513164
66Phagosome_Homo sapiens_hsa041450.86232239
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85249604
68Focal adhesion_Homo sapiens_hsa045100.85112101
69HIF-1 signaling pathway_Homo sapiens_hsa040660.82936888
70Mineral absorption_Homo sapiens_hsa049780.82795512
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.81430787
72Bladder cancer_Homo sapiens_hsa052190.80505692
73Platelet activation_Homo sapiens_hsa046110.79540297
74FoxO signaling pathway_Homo sapiens_hsa040680.79492299
75PPAR signaling pathway_Homo sapiens_hsa033200.78850546
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.78739697
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.78516169
78Caffeine metabolism_Homo sapiens_hsa002320.77911658
79Prolactin signaling pathway_Homo sapiens_hsa049170.77611709
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77598030
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.77453545
82Salmonella infection_Homo sapiens_hsa051320.76266920
83Hepatitis C_Homo sapiens_hsa051600.75773745
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.75579761
85Amoebiasis_Homo sapiens_hsa051460.74237924
86Dilated cardiomyopathy_Homo sapiens_hsa054140.72977153
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72624170
88Rheumatoid arthritis_Homo sapiens_hsa053230.72039996
89Dorso-ventral axis formation_Homo sapiens_hsa043200.71936038
90Sphingolipid metabolism_Homo sapiens_hsa006000.71388903
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.71379410
92Prostate cancer_Homo sapiens_hsa052150.70838622
93African trypanosomiasis_Homo sapiens_hsa051430.70826845
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70624394
95Rap1 signaling pathway_Homo sapiens_hsa040150.70425434
96Endometrial cancer_Homo sapiens_hsa052130.70023714
97Colorectal cancer_Homo sapiens_hsa052100.69620214
98Insulin signaling pathway_Homo sapiens_hsa049100.69022105
99Non-small cell lung cancer_Homo sapiens_hsa052230.68584837
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67748207
101Viral carcinogenesis_Homo sapiens_hsa052030.67687113
102Glioma_Homo sapiens_hsa052140.67606350
103Insulin resistance_Homo sapiens_hsa049310.66816580
104Shigellosis_Homo sapiens_hsa051310.66327752
105Notch signaling pathway_Homo sapiens_hsa043300.63315712
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61970563
107ECM-receptor interaction_Homo sapiens_hsa045120.60066498
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58808975
109VEGF signaling pathway_Homo sapiens_hsa043700.58715800
110Steroid biosynthesis_Homo sapiens_hsa001000.57766188
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57365291
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56245992
113Estrogen signaling pathway_Homo sapiens_hsa049150.55339615
114ABC transporters_Homo sapiens_hsa020100.54401976
115Melanoma_Homo sapiens_hsa052180.54395816
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53231153
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.53082866
118Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52528510
119p53 signaling pathway_Homo sapiens_hsa041150.51765508
120AMPK signaling pathway_Homo sapiens_hsa041520.50802395
121Endocytosis_Homo sapiens_hsa041440.46956778

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