CCHCR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.42782898
2fusion of sperm to egg plasma membrane (GO:0007342)8.54118451
3sperm motility (GO:0030317)8.42302771
4axonemal dynein complex assembly (GO:0070286)8.05778121
5acrosome reaction (GO:0007340)7.76903863
6motile cilium assembly (GO:0044458)7.52956735
7epithelial cilium movement (GO:0003351)7.44307935
8multicellular organism reproduction (GO:0032504)7.39939608
9piRNA metabolic process (GO:0034587)7.30594079
10sperm-egg recognition (GO:0035036)7.24049791
11acrosome assembly (GO:0001675)6.94868321
12spermatid development (GO:0007286)6.75342903
13binding of sperm to zona pellucida (GO:0007339)6.52119522
14cilium movement (GO:0003341)6.50478497
15microtubule depolymerization (GO:0007019)6.44806166
16cell-cell recognition (GO:0009988)6.42735698
17cell wall macromolecule catabolic process (GO:0016998)6.35097870
18cell wall macromolecule metabolic process (GO:0044036)6.35097870
19plasma membrane fusion (GO:0045026)6.26183577
20regulation of cilium movement (GO:0003352)6.24929051
21male meiosis (GO:0007140)6.10712754
22epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.86030503
23reproduction (GO:0000003)5.82810917
24synaptonemal complex organization (GO:0070193)5.61663515
25DNA unwinding involved in DNA replication (GO:0006268)5.42989345
26synaptonemal complex assembly (GO:0007130)5.42534821
27male meiosis I (GO:0007141)5.31943263
28DNA methylation involved in gamete generation (GO:0043046)5.27200765
29single fertilization (GO:0007338)5.23974687
30mitotic chromosome condensation (GO:0007076)4.85110056
31fertilization (GO:0009566)4.69679532
32chromosome organization involved in meiosis (GO:0070192)4.60242331
33ventricular system development (GO:0021591)4.59949384
34spermatogenesis (GO:0007283)4.49005159
35male gamete generation (GO:0048232)4.47600772
36peptidyl-arginine omega-N-methylation (GO:0035247)4.41182926
37DNA strand elongation involved in DNA replication (GO:0006271)4.40969673
38meiosis I (GO:0007127)4.34420451
39DNA strand elongation (GO:0022616)4.34385599
40sperm capacitation (GO:0048240)4.31284633
41mitotic G1 DNA damage checkpoint (GO:0031571)4.17787805
42meiotic nuclear division (GO:0007126)4.15430900
43deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.14863379
44gamete generation (GO:0007276)4.14436566
45proline biosynthetic process (GO:0006561)4.12578714
46ribosomal small subunit biogenesis (GO:0042274)4.10248949
47DNA replication initiation (GO:0006270)4.08477541
48telomere maintenance via semi-conservative replication (GO:0032201)4.04582024
49germ cell development (GO:0007281)4.04245213
50histone arginine methylation (GO:0034969)4.02507906
51meiotic cell cycle (GO:0051321)3.89461323
52regulation of translational fidelity (GO:0006450)3.88868471
53centriole assembly (GO:0098534)3.88446970
54microtubule polymerization or depolymerization (GO:0031109)3.82254949
55mitotic sister chromatid segregation (GO:0000070)3.80869227
56synapsis (GO:0007129)3.80754902
57cellular process involved in reproduction in multicellular organism (GO:0022412)3.80636490
58protein retention in ER lumen (GO:0006621)3.80106888
59mitotic G1/S transition checkpoint (GO:0044819)3.73192634
60regulation of mammary gland epithelial cell proliferation (GO:0033599)3.73019914
61left/right pattern formation (GO:0060972)3.71882238
62nucleosome disassembly (GO:0006337)3.71689870
63protein-DNA complex disassembly (GO:0032986)3.71689870
64G1 DNA damage checkpoint (GO:0044783)3.71084818
65peptidyl-arginine methylation (GO:0018216)3.67421189
66peptidyl-arginine N-methylation (GO:0035246)3.67421189
67spliceosomal tri-snRNP complex assembly (GO:0000244)3.59518331
68rRNA transcription (GO:0009303)3.58110697
69protein K6-linked ubiquitination (GO:0085020)3.56775722
70L-serine metabolic process (GO:0006563)3.55729075
71maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.53464162
72G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.49525098
73chromatin assembly (GO:0031497)3.47601370
74negative regulation of inclusion body assembly (GO:0090084)3.43158358
75maturation of SSU-rRNA (GO:0030490)3.42747609
76protein maturation by protein folding (GO:0022417)3.41404197
77kinetochore assembly (GO:0051382)3.37358067
78protein localization to chromosome, centromeric region (GO:0071459)3.35214671
79kinetochore organization (GO:0051383)3.31120812
80transepithelial transport (GO:0070633)3.30200764
81organic cation transport (GO:0015695)3.30073426
82sister chromatid segregation (GO:0000819)3.29715166
83centriole replication (GO:0007099)3.29365816
84formation of translation preinitiation complex (GO:0001731)3.28357357
85regulation of histone H3-K9 methylation (GO:0051570)3.27700363
86DNA conformation change (GO:0071103)3.23267457
87single strand break repair (GO:0000012)3.22479572
88histone exchange (GO:0043486)3.22279556
89paraxial mesoderm development (GO:0048339)3.20822720
90negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.20617040
91ribosomal small subunit assembly (GO:0000028)3.20019250
92multicellular organismal reproductive process (GO:0048609)3.19373272
93muscle cell fate commitment (GO:0042693)3.18371863
94nuclear pore complex assembly (GO:0051292)3.18340240
95apoptotic process involved in morphogenesis (GO:0060561)3.18315665
96pentose metabolic process (GO:0019321)3.16720366
97DNA packaging (GO:0006323)3.16530208
98meiotic cell cycle process (GO:1903046)3.16357903
99regulation of microtubule-based movement (GO:0060632)3.16281816
100establishment of apical/basal cell polarity (GO:0035089)3.16054490
101oxidative phosphorylation (GO:0006119)3.14572066
102planar cell polarity pathway involved in neural tube closure (GO:0090179)3.14469773
103telomere maintenance via recombination (GO:0000722)3.14299749
104DNA topological change (GO:0006265)3.11955969
105DNA replication-dependent nucleosome organization (GO:0034723)3.10869740
106DNA replication-dependent nucleosome assembly (GO:0006335)3.10869740
107cell recognition (GO:0008037)3.10652324
108negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.08978926
109chromosome condensation (GO:0030261)3.06878723
110protein localization to cilium (GO:0061512)3.06762313
111nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.03708760
112microtubule severing (GO:0051013)3.03664114
113regulation of spindle checkpoint (GO:0090231)3.02648400
114GTP biosynthetic process (GO:0006183)3.01734257
115DNA ligation (GO:0006266)2.99261286
116nuclear envelope reassembly (GO:0031468)2.98991962
117mitotic nuclear envelope reassembly (GO:0007084)2.98991962
118spermatid nucleus differentiation (GO:0007289)2.97458847
119intracellular estrogen receptor signaling pathway (GO:0030520)2.97438558
120proline metabolic process (GO:0006560)2.97416055
121translational elongation (GO:0006414)2.97272671
122mitotic recombination (GO:0006312)2.96108302
123DNA replication checkpoint (GO:0000076)2.95390527
124base-excision repair (GO:0006284)2.94835961
125DNA alkylation (GO:0006305)2.94270557
126DNA methylation (GO:0006306)2.94270557
127seminiferous tubule development (GO:0072520)2.93472628
128RNA destabilization (GO:0050779)2.92654142
129GDP-mannose metabolic process (GO:0019673)2.90853065
130DNA strand renaturation (GO:0000733)2.90428604
131regulation of centriole replication (GO:0046599)2.90390084
132protein complex disassembly (GO:0043241)2.88433793
133regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.88043896
134chromatin remodeling at centromere (GO:0031055)2.87033271
135viral transcription (GO:0019083)2.87005429
136DNA duplex unwinding (GO:0032508)2.82176001
137regulation of chromatin binding (GO:0035561)2.82069720
138protein localization to kinetochore (GO:0034501)2.81844329
139ribonucleoprotein complex biogenesis (GO:0022613)2.79461758
140meiotic chromosome segregation (GO:0045132)2.78732770
141translational termination (GO:0006415)2.78596382
142interferon-gamma secretion (GO:0072643)2.78534266
143heterochromatin organization (GO:0070828)2.77674907
144negative regulation of DNA-templated transcription, elongation (GO:0032785)2.77500822
145folic acid metabolic process (GO:0046655)2.76170784
146positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.75171891
147regulation of inclusion body assembly (GO:0090083)2.73534581
148mitotic nuclear envelope disassembly (GO:0007077)2.72795066
149nucleotide-excision repair, DNA gap filling (GO:0006297)2.71701806
150cellular protein complex disassembly (GO:0043624)2.71660273
151regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.71171840
152regulation of nuclear cell cycle DNA replication (GO:0033262)2.70598568
153chromatin assembly or disassembly (GO:0006333)2.70421795
154intraciliary transport (GO:0042073)2.70113648
155cilium organization (GO:0044782)2.68627902
156axoneme assembly (GO:0035082)2.68591208
157regulation of meiosis I (GO:0060631)2.68437004
158establishment or maintenance of monopolar cell polarity (GO:0061339)2.68406881
159establishment of monopolar cell polarity (GO:0061162)2.68406881
160ribosome biogenesis (GO:0042254)2.68003761
161* multicellular organismal development (GO:0007275)2.67832979
162tooth mineralization (GO:0034505)2.67734299
163macromolecular complex disassembly (GO:0032984)2.67407174
164ribosomal large subunit biogenesis (GO:0042273)2.66541800
165protein insertion into membrane (GO:0051205)2.64574536
166cilium assembly (GO:0042384)2.64078768
167pentose-phosphate shunt (GO:0006098)2.63534977
168DNA geometric change (GO:0032392)2.63234174
169viral life cycle (GO:0019058)2.62076722
170UTP biosynthetic process (GO:0006228)2.61719188
171serine family amino acid biosynthetic process (GO:0009070)2.60977275
172establishment of integrated proviral latency (GO:0075713)2.60061707
173muscle organ morphogenesis (GO:0048644)2.59379439
174nuclear pore organization (GO:0006999)2.58859603
175genitalia morphogenesis (GO:0035112)2.58344352
176calcium ion-dependent exocytosis (GO:0017156)2.57993370
177nuclear envelope disassembly (GO:0051081)2.56692342
178membrane disassembly (GO:0030397)2.56692342
179pyrimidine nucleotide catabolic process (GO:0006244)2.56456622
180pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.53384595
181regulation of mitochondrial translation (GO:0070129)2.49602419
182cochlea morphogenesis (GO:0090103)2.49502834
183pore complex assembly (GO:0046931)2.49127651
184snRNA metabolic process (GO:0016073)2.49056790
185UV protection (GO:0009650)2.46865927
186COPI coating of Golgi vesicle (GO:0048205)2.45888678
187Golgi transport vesicle coating (GO:0048200)2.45888678

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.63482775
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.94457101
3EZH2_22144423_ChIP-Seq_EOC_Human4.02037785
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.66684558
5E2F7_22180533_ChIP-Seq_HELA_Human3.36329379
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.99208706
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.96905447
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.72535434
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.67335495
10PCGF2_27294783_Chip-Seq_ESCs_Mouse2.63852697
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.61371221
12VDR_22108803_ChIP-Seq_LS180_Human2.43487114
13VDR_21846776_ChIP-Seq_THP-1_Human2.36902331
14LXR_22292898_ChIP-Seq_THP-1_Human2.34563384
15TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.30778230
16MYC_22102868_ChIP-Seq_BL_Human2.30409747
17PCGF2_27294783_Chip-Seq_NPCs_Mouse2.28168578
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.22826753
19KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.19026575
20KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.19026575
21KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.19026575
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.13636894
23XRN2_22483619_ChIP-Seq_HELA_Human2.09182476
24NFE2_27457419_Chip-Seq_LIVER_Mouse2.05749713
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.00077589
26DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.96501942
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96378219
28* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.95770406
29SUZ12_27294783_Chip-Seq_NPCs_Mouse1.89847577
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85975875
31TET1_21451524_ChIP-Seq_MESCs_Mouse1.84035298
32P68_20966046_ChIP-Seq_HELA_Human1.82656980
33ELK3_25401928_ChIP-Seq_HUVEC_Human1.80225403
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.79353122
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.77251065
36FOXM1_23109430_ChIP-Seq_U2OS_Human1.77061997
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.76318515
38GATA1_26923725_Chip-Seq_HPCs_Mouse1.73830878
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.68889278
40RACK7_27058665_Chip-Seq_MCF-7_Human1.67058927
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65496554
42ZNF263_19887448_ChIP-Seq_K562_Human1.64722908
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.60014665
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57227838
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.55583133
46* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.54628327
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.54513467
48IRF1_19129219_ChIP-ChIP_H3396_Human1.53920553
49ELF1_20517297_ChIP-Seq_JURKAT_Human1.48935412
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48310369
51CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.48159078
52SRY_22984422_ChIP-ChIP_TESTIS_Rat1.48019052
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.47716231
54* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.46634233
55RNF2_27304074_Chip-Seq_NSC_Mouse1.45303028
56RARG_19884340_ChIP-ChIP_MEFs_Mouse1.44993949
57PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.44480949
58* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.43980483
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43773136
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43616272
61EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.41344234
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41332560
63SA1_27219007_Chip-Seq_ERYTHROID_Human1.40756523
64ETS1_20019798_ChIP-Seq_JURKAT_Human1.40537833
65GABP_19822575_ChIP-Seq_HepG2_Human1.39801337
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39152751
67SMC4_20622854_ChIP-Seq_HELA_Human1.38143589
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37607812
69KLF4_18555785_Chip-Seq_ESCs_Mouse1.37568100
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37146877
71CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.36771286
72KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36741572
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.36668763
74NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36462394
75OCT4_18555785_Chip-Seq_ESCs_Mouse1.35822498
76P300_18555785_Chip-Seq_ESCs_Mouse1.34474450
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.33421988
78DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.32911115
79STAT3_18555785_Chip-Seq_ESCs_Mouse1.32080376
80* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30507361
81* STAT1_17558387_ChIP-Seq_HELA_Human1.30326218
82NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.30266516
83E2F1_21310950_ChIP-Seq_MCF-7_Human1.29638575
84TAL1_26923725_Chip-Seq_HPCs_Mouse1.29546705
85CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.29444201
86EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.29429040
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29253073
88ESRRB_18555785_Chip-Seq_ESCs_Mouse1.28900106
89KDM2B_26808549_Chip-Seq_DND41_Human1.28465499
90FOXP1_21924763_ChIP-Seq_HESCs_Human1.27236868
91NANOG_18555785_ChIP-Seq_MESCs_Mouse1.26937291
92BCL6_27268052_Chip-Seq_Bcells_Human1.26789950
93UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26560176
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.25883658
95* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.25708201
96CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24767173
97TTF2_22483619_ChIP-Seq_HELA_Human1.23261969
98P53_22387025_ChIP-Seq_ESCs_Mouse1.22968751
99NCOR1_26117541_ChIP-Seq_K562_Human1.22477358
100E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22293411
101DCP1A_22483619_ChIP-Seq_HELA_Human1.21962554
102SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.21955202
103NMYC_18555785_Chip-Seq_ESCs_Mouse1.21928670
104* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21281211
105CIITA_25753668_ChIP-Seq_RAJI_Human1.20759633
106KAP1_22055183_ChIP-Seq_ESCs_Mouse1.20721144
107BCOR_27268052_Chip-Seq_Bcells_Human1.20407146
108NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20273788
109CRX_20693478_ChIP-Seq_RETINA_Mouse1.20045970
110ZFX_18555785_Chip-Seq_ESCs_Mouse1.18859287
111SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18408604
112PHF8_20622854_ChIP-Seq_HELA_Human1.18213479
113KDM5A_27292631_Chip-Seq_BREAST_Human1.18162095
114E2F1_18555785_Chip-Seq_ESCs_Mouse1.16495583
115STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16035229
116RUNX1_27457419_Chip-Seq_LIVER_Mouse1.15983672
117RARA_24833708_ChIP-Seq_LIVER_Mouse1.15947051
118TCF7_22412390_ChIP-Seq_EML_Mouse1.15911203
119CREB1_26743006_Chip-Seq_LNCaP_Human1.15640848
120SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.14247766
121CTCF_18555785_ChIP-Seq_MESCs_Mouse1.14137387
122ERG_21242973_ChIP-ChIP_JURKAT_Human1.14050157
123ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13824615
124FUS_26573619_Chip-Seq_HEK293_Human1.13264162
125MAF_26560356_Chip-Seq_TH2_Human1.12667682
126ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11463844
127E2F1_20622854_ChIP-Seq_HELA_Human1.11291653
128CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11090907
129TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11080774
130* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10719596
131TP63_17297297_ChIP-ChIP_HaCaT_Human1.10683187
132MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10221439
133* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10131253
134SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09140954
135PU1_27457419_Chip-Seq_LIVER_Mouse1.08988257
136STAT1_20625510_ChIP-Seq_HELA_Human1.08239166
137OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07666220
138MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.07593250
139CMYC_18555785_Chip-Seq_ESCs_Mouse1.07463242
140SMAD1_18555785_Chip-Seq_ESCs_Mouse1.07048711
141SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.06937561
142CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06901852
143KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06899457
144SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.06708705
145CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06174544
146CTCF_18555785_Chip-Seq_ESCs_Mouse1.05731439
147CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05452714
148KDM2B_26808549_Chip-Seq_K562_Human1.05193128
149CTCF_21964334_Chip-Seq_Bcells_Human1.05114309
150RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05025819
151CTCF_26484167_Chip-Seq_Bcells_Mouse1.05015942
152SOX2_18555785_Chip-Seq_ESCs_Mouse1.04968101
153CTCF_27219007_Chip-Seq_Bcells_Human1.04496258
154BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03249987
155SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03139034
156TP53_22127205_ChIP-Seq_IMR90_Human1.02527025
157ATF3_27146783_Chip-Seq_COLON_Human1.02380266
158SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01711039
159TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01594245
160POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01594245
161* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00866919
162SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98703075
163STAT3_18555785_ChIP-Seq_MESCs_Mouse0.97745889
164KDM2B_26808549_Chip-Seq_REH_Human0.96552735
165SOX2_22085726_ChIP-Seq_NPCs_Mouse0.96525419
166KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.95726439
167GATA3_21867929_ChIP-Seq_CD8_Mouse0.95699560
168NFYB_21822215_ChIP-Seq_K562_Human0.95593122
169MYC_19079543_ChIP-ChIP_MESCs_Mouse0.95542460
170YY1_22570637_ChIP-Seq_MALME-3M_Human0.91841126
171WDR5_24793694_ChIP-Seq_LNCAP_Human0.91344438
172CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91133986
173ELK4_26923725_Chip-Seq_MESODERM_Mouse0.90175403
174GF1_26923725_Chip-Seq_HPCs_Mouse0.88644991
175NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.87674006
176RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87572355
177CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.86466034
178TP63_19390658_ChIP-ChIP_HaCaT_Human0.86183552
179RAD21_21589869_ChIP-Seq_MESCs_Mouse0.86012750
180ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.85368937
181CTBP2_25329375_ChIP-Seq_LNCAP_Human0.85038251
182RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.84976736
183MYC_19829295_ChIP-Seq_ESCs_Human0.84622398
184PHF8_20622853_ChIP-Seq_HELA_Human0.81688472
185GATA3_21867929_ChIP-Seq_TH1_Mouse0.81342586
186YY1_21170310_ChIP-Seq_MESCs_Mouse0.79167914
187MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.79101319
188SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.78563802
189POU5F1_16153702_ChIP-ChIP_HESCs_Human0.78551462

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.52898271
2MP0003941_abnormal_skin_development5.10019578
3MP0003698_abnormal_male_reproductive3.94595725
4MP0001929_abnormal_gametogenesis3.65546148
5MP0010030_abnormal_orbit_morphology3.56441320
6MP0008877_abnormal_DNA_methylation3.43750461
7MP0003705_abnormal_hypodermis_morpholog3.35708545
8MP0003136_yellow_coat_color3.11564601
9MP0002210_abnormal_sex_determination2.91016682
10MP0002102_abnormal_ear_morphology2.87664496
11MP0008057_abnormal_DNA_replication2.58442803
12MP0005451_abnormal_body_composition2.48634423
13MP0008058_abnormal_DNA_repair2.41305945
14MP0001145_abnormal_male_reproductive2.39725544
15MP0001188_hyperpigmentation2.31276517
16MP0010094_abnormal_chromosome_stability2.30074606
17MP0002877_abnormal_melanocyte_morpholog2.26496200
18MP0004185_abnormal_adipocyte_glucose2.12679621
19MP0006292_abnormal_olfactory_placode2.10524573
20MP0001730_embryonic_growth_arrest2.09902080
21MP0003111_abnormal_nucleus_morphology2.08117471
22MP0002161_abnormal_fertility/fecundity2.04581450
23MP0000653_abnormal_sex_gland2.03319153
24MP0002234_abnormal_pharynx_morphology1.94407723
25MP0000566_synostosis1.92032749
26MP0004233_abnormal_muscle_weight1.90617210
27MP0001849_ear_inflammation1.87470463
28MP0005076_abnormal_cell_differentiation1.84997801
29MP0002160_abnormal_reproductive_system1.70752174
30MP0000350_abnormal_cell_proliferation1.70552852
31MP0008995_early_reproductive_senescence1.66179554
32MP0002653_abnormal_ependyma_morphology1.63378277
33MP0003786_premature_aging1.59671585
34MP0008932_abnormal_embryonic_tissue1.56565075
35MP0004381_abnormal_hair_follicle1.50580932
36MP0001661_extended_life_span1.50198365
37MP0002277_abnormal_respiratory_mucosa1.47962473
38MP0001348_abnormal_lacrimal_gland1.47522509
39MP0005174_abnormal_tail_pigmentation1.46264223
40MP0002080_prenatal_lethality1.46147993
41MP0000313_abnormal_cell_death1.46047560
42MP0001672_abnormal_embryogenesis/_devel1.45626129
43MP0005380_embryogenesis_phenotype1.45626129
44MP0004858_abnormal_nervous_system1.45403999
45MP0005058_abnormal_lysosome_morphology1.44820489
46MP0005377_hearing/vestibular/ear_phenot1.44022605
47MP0003878_abnormal_ear_physiology1.44022605
48MP0000003_abnormal_adipose_tissue1.43619190
49MP0003693_abnormal_embryo_hatching1.41443611
50MP0005666_abnormal_adipose_tissue1.40400896
51MP0008260_abnormal_autophagy1.39695891
52MP0009333_abnormal_splenocyte_physiolog1.34197969
53MP0003938_abnormal_ear_development1.33418074
54MP0000015_abnormal_ear_pigmentation1.33030047
55MP0000733_abnormal_muscle_development1.32480862
56MP0009672_abnormal_birth_weight1.31116244
57MP0001697_abnormal_embryo_size1.29530567
58MP0000537_abnormal_urethra_morphology1.28892094
59MP0005409_darkened_coat_color1.25377076
60MP0009379_abnormal_foot_pigmentation1.24419058
61MP0000049_abnormal_middle_ear1.23714821
62MP0003984_embryonic_growth_retardation1.21954831
63MP0001873_stomach_inflammation1.21457712
64MP0001727_abnormal_embryo_implantation1.21304875
65MP0005670_abnormal_white_adipose1.20604442
66MP0003077_abnormal_cell_cycle1.14593252
67MP0005375_adipose_tissue_phenotype1.14231158
68MP0000681_abnormal_thyroid_gland1.13507368
69MP0005623_abnormal_meninges_morphology1.11759391
70MP0003453_abnormal_keratinocyte_physiol1.10828774
71MP0001346_abnormal_lacrimal_gland1.10466207
72MP0002088_abnormal_embryonic_growth/wei1.10220527
73MP0000467_abnormal_esophagus_morphology1.07938824
74MP0010307_abnormal_tumor_latency1.07533558
75MP0002092_abnormal_eye_morphology1.07322661
76MP0003123_paternal_imprinting1.07200432
77MP0005389_reproductive_system_phenotype1.06558730
78MP0009053_abnormal_anal_canal1.05992832
79MP0002282_abnormal_trachea_morphology1.05860147
80MP0005171_absent_coat_pigmentation1.05768776
81MP0001986_abnormal_taste_sensitivity1.04970819
82MP0003385_abnormal_body_wall1.03067974
83MP0002249_abnormal_larynx_morphology1.02484480
84MP0005075_abnormal_melanosome_morpholog1.01058805
85MP0002084_abnormal_developmental_patter1.00898933
86MP0002822_catalepsy1.00285681
87MP0003942_abnormal_urinary_system0.98568535
88MP0002177_abnormal_outer_ear0.98267791
89MP0000751_myopathy0.98030490
90MP0003315_abnormal_perineum_morphology0.96267599
91MP0004742_abnormal_vestibular_system0.95213392
92MP0000383_abnormal_hair_follicle0.94701963
93MP0000747_muscle_weakness0.93476293
94MP0004133_heterotaxia0.93454096
95MP0000026_abnormal_inner_ear0.90507232
96MP0000490_abnormal_crypts_of0.90425443
97MP0003937_abnormal_limbs/digits/tail_de0.90104489
98MP0000358_abnormal_cell_content/0.87946537
99MP0002089_abnormal_postnatal_growth/wei0.87919841
100MP0002086_abnormal_extraembryonic_tissu0.87746369
101MP0002932_abnormal_joint_morphology0.87249282
102MP0005330_cardiomyopathy0.86755127
103MP0002095_abnormal_skin_pigmentation0.86492006
104MP0009278_abnormal_bone_marrow0.86250898
105MP0002132_abnormal_respiratory_system0.86184770
106MP0000762_abnormal_tongue_morphology0.84480167
107MP0008007_abnormal_cellular_replicative0.84064317
108MP0003718_maternal_effect0.83771233
109MP0002938_white_spotting0.83660906
110MP0003787_abnormal_imprinting0.83641241
111MP0000647_abnormal_sebaceous_gland0.82989763
112MP0009250_abnormal_appendicular_skeleto0.82666711
113MP0004957_abnormal_blastocyst_morpholog0.82240275
114MP0000759_abnormal_skeletal_muscle0.80937800
115MP0005257_abnormal_intraocular_pressure0.80117665
116MP0005394_taste/olfaction_phenotype0.78532254
117MP0005499_abnormal_olfactory_system0.78532254
118MP0004197_abnormal_fetal_growth/weight/0.78222877
119MP0001485_abnormal_pinna_reflex0.78158289
120MP0010352_gastrointestinal_tract_polyps0.77100344
121MP0002796_impaired_skin_barrier0.75140905
122MP0000579_abnormal_nail_morphology0.75040081
123MP0010630_abnormal_cardiac_muscle0.74290534
124MP0000470_abnormal_stomach_morphology0.74043874
125MP0000858_altered_metastatic_potential0.73974870
126MP0005621_abnormal_cell_physiology0.73352823
127MP0002116_abnormal_craniofacial_bone0.72332485
128MP0002019_abnormal_tumor_incidence0.72234095
129MP0003806_abnormal_nucleotide_metabolis0.71893111
130MP0004134_abnormal_chest_morphology0.71205968
131MP0006072_abnormal_retinal_apoptosis0.68377856
132MP0000462_abnormal_digestive_system0.67913438
133MP0003755_abnormal_palate_morphology0.66187566
134MP0003936_abnormal_reproductive_system0.65228877
135MP0000432_abnormal_head_morphology0.64022941
136MP0001293_anophthalmia0.62226158
137MP0005647_abnormal_sex_gland0.60087997
138MP0001119_abnormal_female_reproductive0.58636191
139MP0005501_abnormal_skin_physiology0.57390546
140MP0002111_abnormal_tail_morphology0.56742231
141MP0001919_abnormal_reproductive_system0.55830174
142MP0002697_abnormal_eye_size0.55777887
143MP0003950_abnormal_plasma_membrane0.54340386
144MP0005503_abnormal_tendon_morphology0.53496705
145MP0005391_vision/eye_phenotype0.53110939
146MP0002098_abnormal_vibrissa_morphology0.52960505
147MP0005423_abnormal_somatic_nervous0.52832773
148MP0002233_abnormal_nose_morphology0.51870043
149MP0003861_abnormal_nervous_system0.51237356
150MP0001286_abnormal_eye_development0.51076297
151MP0001963_abnormal_hearing_physiology0.50463674
152MP0002085_abnormal_embryonic_tissue0.49621793
153MP0005253_abnormal_eye_physiology0.49358336
154MP0003115_abnormal_respiratory_system0.48916921
155MP0005645_abnormal_hypothalamus_physiol0.48757642
156MP0002114_abnormal_axial_skeleton0.48018644
157MP0009046_muscle_twitch0.47988105
158MP0000678_abnormal_parathyroid_gland0.47533364
159MP0001664_abnormal_digestion0.45517725

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.82441465
2Absent/shortened dynein arms (HP:0200106)9.82074998
3Dynein arm defect of respiratory motile cilia (HP:0012255)9.82074998
4Abnormal respiratory motile cilium morphology (HP:0005938)7.16321129
5Abnormal respiratory epithelium morphology (HP:0012253)7.16321129
6Abnormal respiratory motile cilium physiology (HP:0012261)6.90189408
7Abnormal ciliary motility (HP:0012262)6.02750574
8Rhinitis (HP:0012384)5.33481515
9Chromosomal breakage induced by crosslinking agents (HP:0003221)4.22951655
10Chronic bronchitis (HP:0004469)4.02874948
11Nephronophthisis (HP:0000090)4.00973544
12Infertility (HP:0000789)3.94924629
13Nasal polyposis (HP:0100582)3.87225860
14Chromsome breakage (HP:0040012)3.65212476
15Broad distal phalanx of finger (HP:0009836)3.51889646
16Truncus arteriosus (HP:0001660)3.41734402
17Hyperacusis (HP:0010780)3.41622604
18Tubulointerstitial nephritis (HP:0001970)3.36119669
19Bronchiectasis (HP:0002110)3.35358453
20Reticulocytopenia (HP:0001896)3.29444243
21Abnormality of the renal medulla (HP:0100957)3.26858692
22Duplicated collecting system (HP:0000081)3.25013399
23Abnormal number of erythroid precursors (HP:0012131)3.17571105
24Double outlet right ventricle (HP:0001719)3.17113981
25Congenital malformation of the right heart (HP:0011723)3.17113981
26Abnormality of cells of the erythroid lineage (HP:0012130)3.10314386
27Unilateral renal agenesis (HP:0000122)3.02607126
28Abnormality of the renal collecting system (HP:0004742)2.94894107
29Abnormality of the nasal mucosa (HP:0000433)2.89130964
30Impulsivity (HP:0100710)2.85856406
31Hyperthyroidism (HP:0000836)2.79572405
32Stridor (HP:0010307)2.78398470
33Abnormality of the aortic arch (HP:0012303)2.77381301
34Transposition of the great arteries (HP:0001669)2.73170429
35Abnormal connection of the cardiac segments (HP:0011545)2.73170429
36Abnormal ventriculo-arterial connection (HP:0011563)2.73170429
37Aplasia/Hypoplasia of the uvula (HP:0010293)2.63291180
38Flattened epiphyses (HP:0003071)2.60540395
39Progressive muscle weakness (HP:0003323)2.59889208
40Abnormality of reticulocytes (HP:0004312)2.59325478
41Bronchitis (HP:0012387)2.57837220
42Ectopic kidney (HP:0000086)2.57670554
43Recurrent sinusitis (HP:0011108)2.56266821
44Abnormality of the preputium (HP:0100587)2.55509899
45Achilles tendon contracture (HP:0001771)2.53697752
46Meckel diverticulum (HP:0002245)2.53429806
47Rectal prolapse (HP:0002035)2.53391566
48Ulnar bowing (HP:0003031)2.53219383
49Atelectasis (HP:0100750)2.51667832
50Ragged-red muscle fibers (HP:0003200)2.50658483
51Cholecystitis (HP:0001082)2.48171385
52Abnormal gallbladder physiology (HP:0012438)2.48171385
53Selective tooth agenesis (HP:0001592)2.46005063
54Abnormality of the ileum (HP:0001549)2.43364115
55Myopathic facies (HP:0002058)2.42917716
56Abnormal number of incisors (HP:0011064)2.41578488
57Abnormality of the calcaneus (HP:0008364)2.40282155
58Molar tooth sign on MRI (HP:0002419)2.39785248
59Abnormality of midbrain morphology (HP:0002418)2.39785248
60Insomnia (HP:0100785)2.38617677
61Microvesicular hepatic steatosis (HP:0001414)2.38065515
62Abnormal spermatogenesis (HP:0008669)2.37617189
63Distal upper limb amyotrophy (HP:0007149)2.37569069
64Upper limb amyotrophy (HP:0009129)2.37569069
65Squamous cell carcinoma (HP:0002860)2.34303745
66Male infertility (HP:0003251)2.33472207
67Long palpebral fissure (HP:0000637)2.33174670
68Supernumerary spleens (HP:0009799)2.32876519
69Recurrent otitis media (HP:0000403)2.30294861
70Abnormality of the thoracic spine (HP:0100711)2.22914117
71Upper limb muscle weakness (HP:0003484)2.22289711
72Reticulocytosis (HP:0001923)2.20987080
73Postaxial foot polydactyly (HP:0001830)2.19911229
74Absent thumb (HP:0009777)2.18732156
75Breast hypoplasia (HP:0003187)2.18509046
76Increased nuchal translucency (HP:0010880)2.18405561
77Abnormality of the Achilles tendon (HP:0005109)2.17296578
78Abnormality of the tricuspid valve (HP:0001702)2.16663352
79Thoracic kyphosis (HP:0002942)2.14133054
80Patellar dislocation (HP:0002999)2.13931815
81Hypertensive crisis (HP:0100735)2.11175201
82Tubulointerstitial abnormality (HP:0001969)2.09187934
83Hypoplasia of the capital femoral epiphysis (HP:0003090)2.08036944
84Abnormality of chromosome stability (HP:0003220)2.07369012
85Medial flaring of the eyebrow (HP:0010747)2.02883233
8611 pairs of ribs (HP:0000878)2.02593760
87Hand muscle atrophy (HP:0009130)2.02504779
88Stage 5 chronic kidney disease (HP:0003774)2.02016432
89Optic nerve coloboma (HP:0000588)1.98216213
90Bell-shaped thorax (HP:0001591)1.97837115
91Fibular hypoplasia (HP:0003038)1.97545092
92Sex reversal (HP:0012245)1.97307018
93Abnormal sex determination (HP:0012244)1.97307018
94Gonadotropin excess (HP:0000837)1.96342834
95Tubular atrophy (HP:0000092)1.96325627
96Duplication of thumb phalanx (HP:0009942)1.93767410
97Metaphyseal cupping (HP:0003021)1.93749294
98High anterior hairline (HP:0009890)1.93687102
99Nephroblastoma (Wilms tumor) (HP:0002667)1.91522310
100Preauricular pit (HP:0004467)1.90639775
101Periauricular skin pits (HP:0100277)1.90639775
102Renal dysplasia (HP:0000110)1.90454125
103Facial cleft (HP:0002006)1.90331577
104Hypoplastic left heart (HP:0004383)1.89812388
105Colitis (HP:0002583)1.89654319
106Congenital hepatic fibrosis (HP:0002612)1.88829506
107Triphalangeal thumb (HP:0001199)1.88194942
108Median cleft lip (HP:0000161)1.88182002
109Proximal placement of thumb (HP:0009623)1.88062130
110Male pseudohermaphroditism (HP:0000037)1.87936013
111Clubbing of toes (HP:0100760)1.87728147
112Renal duplication (HP:0000075)1.87155218
113Deep palmar crease (HP:0006191)1.86795280
114Pointed chin (HP:0000307)1.86742261
115Renovascular hypertension (HP:0100817)1.84996682
116Pallor (HP:0000980)1.84920165
117True hermaphroditism (HP:0010459)1.84619991
118Seborrheic dermatitis (HP:0001051)1.82931108
119Abnormality of cochlea (HP:0000375)1.82606129
120Pseudobulbar signs (HP:0002200)1.82443241
121Dyschromatopsia (HP:0007641)1.81745623
122Disproportionate tall stature (HP:0001519)1.81734413
123Abnormality of the dental pulp (HP:0006479)1.80273858
124Absent radius (HP:0003974)1.79891746
125Deviation of the thumb (HP:0009603)1.79795297
126Flat acetabular roof (HP:0003180)1.79697397
127Trismus (HP:0000211)1.79044521
128Overriding aorta (HP:0002623)1.78978314
129Decreased central vision (HP:0007663)1.78442649
130Abnormality of molar morphology (HP:0011070)1.78274416
131Abnormality of molar (HP:0011077)1.78274416
132Bowel incontinence (HP:0002607)1.78033170
133Abnormality of the renal cortex (HP:0011035)1.77808855
134Abnormality of dentin (HP:0010299)1.77507691
135Hypoparathyroidism (HP:0000829)1.77136511
136Embryonal renal neoplasm (HP:0011794)1.76211182
137Centrally nucleated skeletal muscle fibers (HP:0003687)1.75648298
138Macrocytic anemia (HP:0001972)1.75367011
139Duodenal stenosis (HP:0100867)1.74596463
140Small intestinal stenosis (HP:0012848)1.74596463
141Absent forearm bone (HP:0003953)1.73990784
142Aplasia involving forearm bones (HP:0009822)1.73990784
143Abnormality of the dental root (HP:0006486)1.73835828
144Taurodontia (HP:0000679)1.73835828
145Abnormality of permanent molar morphology (HP:0011071)1.73835828
146Short nail (HP:0001799)1.73697580
147Hemorrhage of the eye (HP:0011885)1.73623483
148Cholelithiasis (HP:0001081)1.73538115
149Biconcave vertebral bodies (HP:0004586)1.72742218
150Gout (HP:0001997)1.72688329
151Prostate neoplasm (HP:0100787)1.72534236
152Abnormality of chromosome segregation (HP:0002916)1.71926344
153Abnormal large intestine physiology (HP:0012700)1.71641895
154Poikiloderma (HP:0001029)1.71590666
155Atresia of the external auditory canal (HP:0000413)1.71038255
156Turricephaly (HP:0000262)1.70157500
157Aplasia/Hypoplasia of the sacrum (HP:0008517)1.69734302
158Abnormality of DNA repair (HP:0003254)1.68163897
159Bulbar palsy (HP:0001283)1.67987795
160Septo-optic dysplasia (HP:0100842)1.67539387
161Abnormality of the phalanges of the hallux (HP:0010057)1.66244384
162Azoospermia (HP:0000027)1.64888836
163Cleft eyelid (HP:0000625)1.64885800
164Absent epiphyses (HP:0010577)1.64728635
165Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.64728635
166Short thumb (HP:0009778)1.64379336
167Microretrognathia (HP:0000308)1.64249869
168Premature skin wrinkling (HP:0100678)1.63342185
169Short ribs (HP:0000773)1.62779027
170Progressive external ophthalmoplegia (HP:0000590)1.62514375
171Flared metaphyses (HP:0003015)1.62463397
172Anencephaly (HP:0002323)1.62123280
173Abnormality of the distal phalanx of the thumb (HP:0009617)1.61851191
174Elfin facies (HP:0004428)1.61194100
175Hypoplasia of the radius (HP:0002984)1.61146728
176Recurrent bronchitis (HP:0002837)1.61145401
177Abnormality of the distal phalanges of the toes (HP:0010182)1.59973935
178Increased connective tissue (HP:0009025)1.59434198
179Pancreatic fibrosis (HP:0100732)1.58891708
180Aplasia/Hypoplasia of the earlobes (HP:0009906)1.56738434
181Abnormality of the carotid arteries (HP:0005344)1.56245993
182Absent septum pellucidum (HP:0001331)1.53833803
183Sloping forehead (HP:0000340)1.49350383
184Bone marrow hypocellularity (HP:0005528)1.48129081
185Optic nerve hypoplasia (HP:0000609)1.46793946
186Attenuation of retinal blood vessels (HP:0007843)1.46623259
187Horseshoe kidney (HP:0000085)1.46135211

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG15.94000048
2STK165.12679969
3PDK34.30487387
4PDK44.30487387
5VRK24.12206839
6TLK13.82184490
7TESK13.75337256
8TRIB33.73422293
9ICK3.39707894
10ZAK3.00463773
11EEF2K2.92650255
12PDK22.87171712
13NEK22.72967471
14TAF12.63227383
15PRKD32.46019457
16STK392.30151874
17PNCK2.02285091
18VRK11.59634346
19PRPF4B1.58907724
20WNK41.58399052
21TTK1.57731430
22MAPK151.47959764
23CASK1.45828165
24ERN11.43516849
25PLK41.43223579
26SIK11.36296331
27MAP3K101.36110012
28MKNK21.35146973
29BLK1.25446542
30CDK81.25245629
31PTK2B1.21681195
32DYRK31.20884639
33BRSK11.20635057
34WEE11.19968104
35CDC71.18213442
36BRAF1.17424411
37ARAF1.17165081
38CLK11.16382910
39PKN11.15479637
40MAP3K81.14230986
41MST1R1.13896009
42EIF2AK21.12239282
43TTN1.08549479
44MAPK111.08251401
45NEK61.04649030
46RPS6KA51.04382087
47SRPK11.04368806
48ATR1.02750537
49MAP3K110.99219989
50IRAK30.98933812
51CHEK20.98804753
52YES10.98574810
53IRAK10.97941032
54EIF2AK10.96712352
55PBK0.95341903
56TNIK0.94780844
57FGFR40.93740405
58PLK10.93225393
59KDR0.91637359
60TAOK20.90458199
61GRK10.90376623
62IRAK40.90168835
63STK40.90124374
64DYRK1B0.88337184
65BMX0.87142126
66RPS6KB20.87056480
67STK380.86982282
68IRAK20.86599211
69MTOR0.86243363
70BMPR1B0.83119192
71CDK70.81888962
72NEK10.79321510
73WNK10.78109898
74MKNK10.78073707
75NTRK20.77824854
76ADRBK20.77561224
77LATS20.77064043
78BCKDK0.76158874
79DAPK10.75961796
80CAMK1D0.75924886
81BRD40.75619692
82BUB10.74439235
83AURKA0.73831316
84MST40.72513569
85MAP3K140.72284431
86CHEK10.71712429
87STK30.69151250
88MELK0.68863534
89AKT30.68714849
90PASK0.68050305
91EPHA20.67280469
92CDK120.66196097
93ATM0.65595060
94CCNB10.65311049
95AURKB0.64720911
96CDK11A0.63324837
97PKN20.62970700
98PDGFRA0.62929254
99PAK40.62778339
100PTK60.62613165
101DYRK20.59058830
102RIPK10.58039503
103NME10.58009856
104MAPKAPK30.56779344
105CSNK1A1L0.55798024
106MAPKAPK50.55387564
107MAP2K30.53821258
108PDPK10.53817568
109MAP2K20.53807355
110NME20.53417345
111CDK30.52977618
112RPS6KC10.52853177
113RPS6KL10.52853177
114CSNK1G30.52141433
115STK38L0.51688981
116RPS6KA20.51484568
117TXK0.50919006
118CDK150.50516339
119PAK10.50506111
120PIM20.49764518
121TYRO30.49657778
122HIPK20.48988449
123LRRK20.48700269
124CAMK1G0.47834695
125MARK20.47743956
126KSR20.47300206
127DDR20.46090934
128CDK40.45559761
129MAP3K60.44515044
130DAPK30.44388485
131CDK180.41667687
132MET0.41281398
133CDC42BPA0.40445750
134CDK140.38214463
135CSNK2A10.37452298
136NUAK10.37065543
137PRKD20.36874436
138PRKCQ0.36820547
139AKT20.36654374
140RPS6KA60.35290181
141PIM10.35042722
142RPS6KA10.33725620
143LATS10.33306455
144SIK20.31758518
145CSK0.30127514
146CSNK2A20.29454867
147PIK3CG0.29350269
148CDK10.29259512
149TNK20.28498623
150TESK20.28351926
151CSNK1D0.24494069
152MUSK0.23645873
153GRK70.22948114
154CDK20.22094864
155PAK20.21210513
156FGR0.20189281
157RIPK40.20123639
158EPHB20.19326606
159ADRBK10.19206839
160PRKCI0.19063393
161CDK90.18956196
162TEC0.17689211

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034604.23758053
2Ribosome_Homo sapiens_hsa030103.72972129
3DNA replication_Homo sapiens_hsa030303.04722584
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.87530924
5Biosynthesis of amino acids_Homo sapiens_hsa012302.84781151
6Basal transcription factors_Homo sapiens_hsa030222.83852495
7Homologous recombination_Homo sapiens_hsa034402.80523954
8Mismatch repair_Homo sapiens_hsa034302.67770995
9Spliceosome_Homo sapiens_hsa030402.39961031
10Linoleic acid metabolism_Homo sapiens_hsa005912.38021850
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.19495306
12Vitamin B6 metabolism_Homo sapiens_hsa007502.18803460
13Fructose and mannose metabolism_Homo sapiens_hsa000512.08297274
14RNA polymerase_Homo sapiens_hsa030202.01449709
15Nucleotide excision repair_Homo sapiens_hsa034201.92316890
16Systemic lupus erythematosus_Homo sapiens_hsa053221.90545734
17Huntingtons disease_Homo sapiens_hsa050161.81953959
18mRNA surveillance pathway_Homo sapiens_hsa030151.81103707
19Pyrimidine metabolism_Homo sapiens_hsa002401.79549534
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.78947886
21RNA transport_Homo sapiens_hsa030131.78750057
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.76119078
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.74859394
24Base excision repair_Homo sapiens_hsa034101.71289620
25Bladder cancer_Homo sapiens_hsa052191.68133709
26Ether lipid metabolism_Homo sapiens_hsa005651.65764087
27Carbon metabolism_Homo sapiens_hsa012001.65108508
28Galactose metabolism_Homo sapiens_hsa000521.58403587
29Notch signaling pathway_Homo sapiens_hsa043301.57145109
30Arachidonic acid metabolism_Homo sapiens_hsa005901.56818088
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.52062618
32Non-homologous end-joining_Homo sapiens_hsa034501.51155691
33Central carbon metabolism in cancer_Homo sapiens_hsa052301.36926960
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.36414582
35Purine metabolism_Homo sapiens_hsa002301.35918034
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.35235312
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.33434563
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.30526839
39Chronic myeloid leukemia_Homo sapiens_hsa052201.29743744
40Cell cycle_Homo sapiens_hsa041101.26482040
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.23958597
42Fatty acid biosynthesis_Homo sapiens_hsa000611.21363991
43Non-small cell lung cancer_Homo sapiens_hsa052231.20474422
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.17001328
45Oxidative phosphorylation_Homo sapiens_hsa001901.15202495
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14548756
47Phototransduction_Homo sapiens_hsa047441.12925024
48Taste transduction_Homo sapiens_hsa047421.11074993
49Lysine degradation_Homo sapiens_hsa003101.10330864
50RNA degradation_Homo sapiens_hsa030181.07817293
51Thyroid cancer_Homo sapiens_hsa052161.07457026
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04173597
53Sphingolipid metabolism_Homo sapiens_hsa006001.03023821
54Arginine and proline metabolism_Homo sapiens_hsa003301.01653694
55p53 signaling pathway_Homo sapiens_hsa041151.01507759
56Autoimmune thyroid disease_Homo sapiens_hsa053200.96899378
57Proteasome_Homo sapiens_hsa030500.96475662
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.95730664
59Pancreatic cancer_Homo sapiens_hsa052120.94529646
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93099429
61Alcoholism_Homo sapiens_hsa050340.90511773
62N-Glycan biosynthesis_Homo sapiens_hsa005100.88779909
63Acute myeloid leukemia_Homo sapiens_hsa052210.87769644
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87418238
65Basal cell carcinoma_Homo sapiens_hsa052170.87068456
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86607859
67VEGF signaling pathway_Homo sapiens_hsa043700.86597374
68Other glycan degradation_Homo sapiens_hsa005110.83598809
69Cardiac muscle contraction_Homo sapiens_hsa042600.80993303
70Alzheimers disease_Homo sapiens_hsa050100.80319903
71Hedgehog signaling pathway_Homo sapiens_hsa043400.79294180
72NF-kappa B signaling pathway_Homo sapiens_hsa040640.78088171
73Dorso-ventral axis formation_Homo sapiens_hsa043200.76882308
74Parkinsons disease_Homo sapiens_hsa050120.75840804
75Asthma_Homo sapiens_hsa053100.75333647
76Phenylalanine metabolism_Homo sapiens_hsa003600.75174457
77Graft-versus-host disease_Homo sapiens_hsa053320.73005171
78Folate biosynthesis_Homo sapiens_hsa007900.72969373
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71489018
80Measles_Homo sapiens_hsa051620.70435525
81Arginine biosynthesis_Homo sapiens_hsa002200.70086809
82Primary immunodeficiency_Homo sapiens_hsa053400.66055105
83Allograft rejection_Homo sapiens_hsa053300.65690630
84Hematopoietic cell lineage_Homo sapiens_hsa046400.65359835
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65077374
86Epstein-Barr virus infection_Homo sapiens_hsa051690.64551446
87MicroRNAs in cancer_Homo sapiens_hsa052060.63868914
88Oocyte meiosis_Homo sapiens_hsa041140.63611632
89Glutathione metabolism_Homo sapiens_hsa004800.62212665
90Insulin signaling pathway_Homo sapiens_hsa049100.62056645
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61752921
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61744196
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60606269
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59913705
95Herpes simplex infection_Homo sapiens_hsa051680.59261660
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59091243
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58643418
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57928865
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.57786051
100Endometrial cancer_Homo sapiens_hsa052130.57379526
101AMPK signaling pathway_Homo sapiens_hsa041520.57240530
102One carbon pool by folate_Homo sapiens_hsa006700.57092753
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56866163
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56709391
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55875175
106Mineral absorption_Homo sapiens_hsa049780.54559871
107Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54016054
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53814410
109ABC transporters_Homo sapiens_hsa020100.53572391
110Glioma_Homo sapiens_hsa052140.53498520
111Colorectal cancer_Homo sapiens_hsa052100.52982171
112Antigen processing and presentation_Homo sapiens_hsa046120.52160080
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52026750
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.51885666
115Apoptosis_Homo sapiens_hsa042100.49255157
116mTOR signaling pathway_Homo sapiens_hsa041500.49133786
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.47288763
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45005170
119Wnt signaling pathway_Homo sapiens_hsa043100.43944922
120Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42902486
121Malaria_Homo sapiens_hsa051440.42748100
122Prion diseases_Homo sapiens_hsa050200.40965594
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40380484
124Prostate cancer_Homo sapiens_hsa052150.40031499
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37997070
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35982581
127Hepatitis B_Homo sapiens_hsa051610.35939593
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35231738
129Nicotine addiction_Homo sapiens_hsa050330.35111122
130Metabolic pathways_Homo sapiens_hsa011000.33760281
131Viral carcinogenesis_Homo sapiens_hsa052030.33572389
132Drug metabolism - other enzymes_Homo sapiens_hsa009830.32621527
133Fatty acid metabolism_Homo sapiens_hsa012120.30939031
134Hippo signaling pathway_Homo sapiens_hsa043900.30792753
135Steroid biosynthesis_Homo sapiens_hsa001000.30467946
136Selenocompound metabolism_Homo sapiens_hsa004500.30085417
137ECM-receptor interaction_Homo sapiens_hsa045120.28986391
138HTLV-I infection_Homo sapiens_hsa051660.27812836
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27795987
140Tyrosine metabolism_Homo sapiens_hsa003500.27736409
141Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27669399
142Influenza A_Homo sapiens_hsa051640.26018362
143Jak-STAT signaling pathway_Homo sapiens_hsa046300.25764315
144Adipocytokine signaling pathway_Homo sapiens_hsa049200.25086765
145Protein digestion and absorption_Homo sapiens_hsa049740.24972593
146Axon guidance_Homo sapiens_hsa043600.24770445
147Melanoma_Homo sapiens_hsa052180.24614438
148NOD-like receptor signaling pathway_Homo sapiens_hsa046210.24464119
149Pyruvate metabolism_Homo sapiens_hsa006200.24190711
150Glucagon signaling pathway_Homo sapiens_hsa049220.22824500
151Sulfur relay system_Homo sapiens_hsa041220.21306435
152Pentose phosphate pathway_Homo sapiens_hsa000300.20064059
153Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.19987645
154Small cell lung cancer_Homo sapiens_hsa052220.19374198
155Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19173393
156Pathways in cancer_Homo sapiens_hsa052000.19000725

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