CCIN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a basic protein of the sperm head cytoskeleton. This protein contains kelch repeats and a BTB/POZ domain and is necessary for normal morphology during sperm differentiation. This gene is intronless. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.98598122
2spermatid development (GO:0007286)9.89891491
3motile cilium assembly (GO:0044458)9.87105230
4plasma membrane fusion (GO:0045026)9.86415713
5reproduction (GO:0000003)9.31215250
6regulation of cilium movement (GO:0003352)9.00598790
7cilium or flagellum-dependent cell motility (GO:0001539)8.86392658
8cilium movement (GO:0003341)8.21305176
9negative regulation of inclusion body assembly (GO:0090084)7.56561154
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.56553289
11sperm capacitation (GO:0048240)7.40933141
12single fertilization (GO:0007338)7.31008459
13synaptonemal complex organization (GO:0070193)7.05794243
14piRNA metabolic process (GO:0034587)6.96193749
15synaptonemal complex assembly (GO:0007130)6.87528643
16male meiosis (GO:0007140)6.85225650
17microtubule depolymerization (GO:0007019)6.83988648
18organic cation transport (GO:0015695)6.79630126
19* spermatogenesis (GO:0007283)6.76767937
20* male gamete generation (GO:0048232)6.74336227
21regulation of inclusion body assembly (GO:0090083)6.28908200
22fertilization (GO:0009566)6.23056573
23* gamete generation (GO:0007276)6.19893742
24response to pheromone (GO:0019236)6.02912694
25calcium ion-dependent exocytosis (GO:0017156)5.67981182
26germ cell development (GO:0007281)5.49022119
27chromosome condensation (GO:0030261)5.41352402
28protein targeting to Golgi (GO:0000042)5.40487957
29cellular process involved in reproduction in multicellular organism (GO:0022412)5.39103265
30regulation of microtubule-based movement (GO:0060632)5.33723464
31ventricular system development (GO:0021591)5.27459647
32spermatid nucleus differentiation (GO:0007289)5.19823151
33DNA packaging (GO:0006323)5.15310686
34establishment of protein localization to Golgi (GO:0072600)5.14050349
35retrograde transport, vesicle recycling within Golgi (GO:0000301)5.07670527
36cell recognition (GO:0008037)5.04627291
37rRNA methylation (GO:0031167)5.01264733
38glycerol ether metabolic process (GO:0006662)4.95881469
39microtubule severing (GO:0051013)4.89487956
40* multicellular organismal reproductive process (GO:0048609)4.88291787
41male meiosis I (GO:0007141)4.82404690
42positive regulation of myotube differentiation (GO:0010831)4.82384292
43positive regulation of interleukin-8 secretion (GO:2000484)4.75772445
44phosphatidylethanolamine biosynthetic process (GO:0006646)4.66249842
45negative regulation of nitric-oxide synthase activity (GO:0051001)4.65589120
46chromosome organization involved in meiosis (GO:0070192)4.65094107
47ether metabolic process (GO:0018904)4.57931870
48myoblast fusion (GO:0007520)4.55215542
49seminiferous tubule development (GO:0072520)4.53097785
50left/right pattern formation (GO:0060972)4.46714785
51DNA methylation involved in gamete generation (GO:0043046)4.45083617
52antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.35433366
53phosphatidylethanolamine metabolic process (GO:0046337)4.31443302
54rRNA modification (GO:0000154)4.31307335
55sexual reproduction (GO:0019953)4.27878951
56multicellular organismal movement (GO:0050879)4.22852511
57musculoskeletal movement (GO:0050881)4.22852511
58chaperone-mediated protein complex assembly (GO:0051131)4.19454641
59meiotic nuclear division (GO:0007126)4.12684729
60single strand break repair (GO:0000012)4.10917590
61regulation of sarcomere organization (GO:0060297)4.09244186
62syncytium formation by plasma membrane fusion (GO:0000768)4.05660518
63protein localization to Golgi apparatus (GO:0034067)4.02568263
64regulation of p38MAPK cascade (GO:1900744)3.99457668
65* multicellular organismal development (GO:0007275)3.92506496
66regulation of T-helper 2 cell differentiation (GO:0045628)3.90065130
67cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.89374249
68negative regulation of protein localization to cell surface (GO:2000009)3.83075151
69meiosis I (GO:0007127)3.82961262
70positive regulation of chemokine secretion (GO:0090197)3.74104521
71response to gravity (GO:0009629)3.73253505
72negative regulation of muscle hypertrophy (GO:0014741)3.69065792
73protein polyglutamylation (GO:0018095)3.67728921
74regulation of interleukin-8 secretion (GO:2000482)3.61920597
75glomerular visceral epithelial cell development (GO:0072015)3.61372416
76membrane raft organization (GO:0031579)3.56316622
77microtubule polymerization or depolymerization (GO:0031109)3.51016238
78regulation of spindle checkpoint (GO:0090231)3.44355124
79positive regulation of Rab GTPase activity (GO:0032851)3.42856281
80regulation of Rab GTPase activity (GO:0032313)3.42856281
81kidney mesenchyme development (GO:0072074)3.42024927
82metanephric mesenchyme development (GO:0072075)3.41404571
83interferon-gamma secretion (GO:0072643)3.40322323
84plasma membrane repair (GO:0001778)3.40038171
85cranial nerve morphogenesis (GO:0021602)3.39316301
86genitalia morphogenesis (GO:0035112)3.39161086
87regulation of transcription involved in cell fate commitment (GO:0060850)3.38523769
88cellular ketone body metabolic process (GO:0046950)3.38267434
89sequestering of actin monomers (GO:0042989)3.36370194
90response to muscle activity (GO:0014850)3.35884615
91coenzyme catabolic process (GO:0009109)3.35024101
92protein K11-linked deubiquitination (GO:0035871)3.34365491
93meiotic cell cycle (GO:0051321)3.32209279
94glomerular epithelial cell development (GO:0072310)3.32042543
95syncytium formation (GO:0006949)3.32008735
96negative regulation of Rho protein signal transduction (GO:0035024)3.31019311
97protein refolding (GO:0042026)3.30152317
98regulation of chemokine secretion (GO:0090196)3.24200304
99protein localization to cilium (GO:0061512)3.19352822
100muscle cell cellular homeostasis (GO:0046716)3.18208340
101nucleus organization (GO:0006997)3.17289991
102pinocytosis (GO:0006907)3.15638453
103amino-acid betaine transport (GO:0015838)3.14586406
104carnitine transport (GO:0015879)3.14586406
105nucleoside diphosphate phosphorylation (GO:0006165)3.14059890
106tooth mineralization (GO:0034505)3.11420034
107regulation of skeletal muscle contraction (GO:0014819)3.10493387
108RNA destabilization (GO:0050779)3.07526613
109glycolytic process (GO:0006096)3.06255924
110positive regulation of skeletal muscle tissue development (GO:0048643)3.05622447
111mesenchymal cell differentiation involved in renal system development (GO:2001012)3.05459031
112mesenchymal cell differentiation involved in kidney development (GO:0072161)3.05459031
113positive regulation of macrophage activation (GO:0043032)3.01666328
114muscle cell fate commitment (GO:0042693)3.01534698
115RNA localization (GO:0006403)2.99059443
116monoubiquitinated protein deubiquitination (GO:0035520)2.96951275
117carnitine transmembrane transport (GO:1902603)2.96847559
118mitotic sister chromatid cohesion (GO:0007064)2.94651632
119centriole replication (GO:0007099)2.91638277
120response to acidic pH (GO:0010447)2.91525273
121peptidyl-proline hydroxylation (GO:0019511)2.90494758
122ketone body metabolic process (GO:1902224)2.89905352
123polyol catabolic process (GO:0046174)2.88167332
124cilium organization (GO:0044782)2.87409503
125GTP biosynthetic process (GO:0006183)2.86871503
126embryonic viscerocranium morphogenesis (GO:0048703)2.86849923
127negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.84704026
128axoneme assembly (GO:0035082)2.84298470
129alditol metabolic process (GO:0019400)2.82346511
130negative regulation of cardiac muscle tissue growth (GO:0055022)2.77929142
131cilium assembly (GO:0042384)2.76243730
132polyamine biosynthetic process (GO:0006596)2.76191390
133synapsis (GO:0007129)2.73805887
134meiotic cell cycle process (GO:1903046)2.73515420
135microtubule-based movement (GO:0007018)2.72366231
136cellular component assembly involved in morphogenesis (GO:0010927)2.71123578
137cilium morphogenesis (GO:0060271)2.70643191
138regulation of cilium assembly (GO:1902017)2.70247061
139chromatin silencing (GO:0006342)2.67877040
140UTP biosynthetic process (GO:0006228)2.55553718
141peptidyl-glutamic acid modification (GO:0018200)2.54959655
142intraciliary transport (GO:0042073)2.53724510
143negative regulation of organelle assembly (GO:1902116)2.53500463
144mitochondrion degradation (GO:0000422)2.49671285
145membrane protein intracellular domain proteolysis (GO:0031293)2.47521243
146gene silencing by RNA (GO:0031047)2.43336866
147sperm motility (GO:0030317)14.2492269
148cell wall macromolecule catabolic process (GO:0016998)13.0338014
149cell wall macromolecule metabolic process (GO:0044036)13.0338014
150fusion of sperm to egg plasma membrane (GO:0007342)12.9889085
151acrosome reaction (GO:0007340)12.5992384
152sperm-egg recognition (GO:0035036)11.6459073
153acrosome assembly (GO:0001675)11.3803800
154multicellular organism reproduction (GO:0032504)10.7502562
155binding of sperm to zona pellucida (GO:0007339)10.5534473
156cell-cell recognition (GO:0009988)10.4370368
157axonemal dynein complex assembly (GO:0070286)10.0004879

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.07934918
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.06132213
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.00874133
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.95997294
5EZH2_22144423_ChIP-Seq_EOC_Human3.95048606
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.26592306
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.01511659
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.93036522
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.75584894
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.74618256
11VDR_22108803_ChIP-Seq_LS180_Human2.54708742
12TP53_18474530_ChIP-ChIP_U2OS_Human2.33356356
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.32977858
14GATA1_26923725_Chip-Seq_HPCs_Mouse2.30657241
15* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.15736296
16EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.09940094
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.05046714
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01993051
19CJUN_26792858_Chip-Seq_BT549_Human1.97706086
20VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.94761493
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.91467079
22ZNF274_21170338_ChIP-Seq_K562_Hela1.88617887
23FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81675013
24KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.79285366
25ELK4_26923725_Chip-Seq_MESODERM_Mouse1.78272686
26STAT1_17558387_ChIP-Seq_HELA_Human1.74300411
27FUS_26573619_Chip-Seq_HEK293_Human1.70412369
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.69776351
29TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.68713224
30MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.68246595
31SOX2_22085726_ChIP-Seq_NPCs_Mouse1.65646098
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65554252
33* ERA_21632823_ChIP-Seq_H3396_Human1.65498648
34MYC_19829295_ChIP-Seq_ESCs_Human1.63889126
35* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.63303424
36RAC3_21632823_ChIP-Seq_H3396_Human1.54423425
37GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.54262835
38WDR5_24793694_ChIP-Seq_LNCAP_Human1.52143582
39* GATA3_21867929_ChIP-Seq_CD8_Mouse1.51737313
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.51521314
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.49885165
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49122215
43FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.48923528
44* BRD4_25478319_ChIP-Seq_HGPS_Human1.48060488
45VDR_24787735_ChIP-Seq_THP-1_Human1.44793291
46BP1_19119308_ChIP-ChIP_Hs578T_Human1.44624205
47KDM2B_26808549_Chip-Seq_REH_Human1.44390687
48ARNT_22903824_ChIP-Seq_MCF-7_Human1.43812028
49PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.42798927
50CTCF_27219007_Chip-Seq_Bcells_Human1.42736553
51JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42141716
52KAP1_22055183_ChIP-Seq_ESCs_Mouse1.40973205
53TAL1_26923725_Chip-Seq_HPCs_Mouse1.40384533
54HNFA_21074721_ChIP-Seq_CACO-2_Human1.39818866
55LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.37998356
56ER_23166858_ChIP-Seq_MCF-7_Human1.37275236
57RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.36726097
58CBP_20019798_ChIP-Seq_JUKART_Human1.36260154
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36260154
60P53_21459846_ChIP-Seq_SAOS-2_Human1.36201811
61SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35865562
62PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.33087705
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.31191081
64GATA3_21867929_ChIP-Seq_TH1_Mouse1.31055023
65ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30946997
66REST_21632747_ChIP-Seq_MESCs_Mouse1.30590017
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.29824274
68RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.29423215
69GF1_26923725_Chip-Seq_HPCs_Mouse1.29029869
70JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28693256
71* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.27474703
72P300_19829295_ChIP-Seq_ESCs_Human1.26723987
73PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26383180
74* CSB_26484114_Chip-Seq_FIBROBLAST_Human1.26128248
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25007444
76CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.24786372
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.24280845
78SMAD4_21799915_ChIP-Seq_A2780_Human1.23846821
79TP63_23658742_ChIP-Seq_EP156T_Human1.23589894
80AR_25329375_ChIP-Seq_VCAP_Human1.23154530
81PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22177257
82TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22141739
83FLI1_21867929_ChIP-Seq_TH2_Mouse1.21304656
84CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20534583
85EED_16625203_ChIP-ChIP_MESCs_Mouse1.20249461
86FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.19891871
87* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.19596878
88CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19588404
89TP63_22573176_ChIP-Seq_HFKS_Human1.19493206
90EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.19362793
91TAF2_19829295_ChIP-Seq_ESCs_Human1.19098436
92SPI1_26923725_Chip-Seq_HPCs_Mouse1.18736470
93SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17335929
94TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16435419
95CBX2_22325352_ChIP-Seq_293T-Rex_Human1.16252940
96SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16166689
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15860911
98PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15783636
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15172409
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15172409
101SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.14198804
102RUNX1_26923725_Chip-Seq_HPCs_Mouse1.13919335
103ETV1_20927104_ChIP-Seq_GIST48_Human1.13758710
104AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13692916
105RBPJ_21746931_ChIP-Seq_IB4_Human1.12555569
106PPAR_26484153_Chip-Seq_NCI-H1993_Human1.12203099
107RXRA_24833708_ChIP-Seq_LIVER_Mouse1.12156388
108ESR1_20079471_ChIP-ChIP_T-47D_Human1.12149732
109CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12047820
110SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11550415
111E2F1_20622854_ChIP-Seq_HELA_Human1.11055343
112SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.10995121
113GATA2_21666600_ChIP-Seq_HMVEC_Human1.10574440
114BCL6_27268052_Chip-Seq_Bcells_Human1.10468180
115MYC_27129775_Chip-Seq_CORNEA_Mouse1.10174202
116PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09889728
117P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08977143
118SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.08969948
119KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08954153
120* OCT4_20526341_ChIP-Seq_ESCs_Human1.07661038
121ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07430671
122GATA6_21074721_ChIP-Seq_CACO-2_Human1.07413115
123RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07304204
124RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07105741
125CRX_20693478_ChIP-Seq_RETINA_Mouse1.06806148
126RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06710106
127EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05626654
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05526377
129TET1_21451524_ChIP-Seq_MESCs_Mouse1.05007253
130JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.04718023
131YY1_22570637_ChIP-Seq_MALME-3M_Human1.04292192
132EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.04215874
133SMAD4_21741376_ChIP-Seq_HESCs_Human1.03895626
134* GATA1_19941827_ChIP-Seq_MEL86_Mouse1.03829676
135CBP_21632823_ChIP-Seq_H3396_Human1.03696046
136PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.03189440
137PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human1.02490369
138RARA_24833708_ChIP-Seq_LIVER_Mouse1.02236767
139CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01856015
140CTCF_20526341_ChIP-Seq_ESCs_Human1.01568008
141ERG_20517297_ChIP-Seq_VCAP_Human1.01418797
142EP300_21415370_ChIP-Seq_HL-1_Mouse1.00861504
143NFYA_21822215_ChIP-Seq_K562_Human1.00384475
144NANOG_18555785_Chip-Seq_ESCs_Mouse1.00258365
145FOXH1_21741376_ChIP-Seq_ESCs_Human0.99908390
146GATA3_21878914_ChIP-Seq_MCF-7_Human0.99879997
147LXR_22292898_ChIP-Seq_THP-1_Human0.99852862
148TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98675097
149SMAD_19615063_ChIP-ChIP_OVARY_Human0.98571761
150TDRD3_21172665_ChIP-Seq_MCF-7_Human0.98129742
151* ESET_19884257_ChIP-Seq_ESCs_Mouse0.97970870
152FOXH1_21741376_ChIP-Seq_EPCs_Human0.97868094
153PHF8_20622853_ChIP-Seq_HELA_Human0.97844777
154SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97135514
155* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96614920
156NFYB_21822215_ChIP-Seq_K562_Human0.96594680
157LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96526677
158* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95777658
159PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.95650272
160OCT4_18555785_Chip-Seq_ESCs_Mouse0.94541723
161ELF1_20517297_ChIP-Seq_JURKAT_Human0.94142815
162SOX11_22085726_ChIP-Seq_ESNs_Mouse0.93320318
163KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.92167983
164FLI1_21867929_ChIP-Seq_CD8_Mouse0.91567047
165BCOR_27268052_Chip-Seq_Bcells_Human0.91514840
166OCT4_21477851_ChIP-Seq_ESCs_Mouse0.91180728
167TAF15_26573619_Chip-Seq_HEK293_Human0.90882937
168P53_22387025_ChIP-Seq_ESCs_Mouse0.90277885
169PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89608039
170NANOG_20526341_ChIP-Seq_ESCs_Human0.89589243
171TBL1_22424771_ChIP-Seq_293T_Human0.88571174
172GF1B_26923725_Chip-Seq_HPCs_Mouse0.87966497
173CMYC_18555785_Chip-Seq_ESCs_Mouse0.86980829
174SMAD4_21741376_ChIP-Seq_EPCs_Human0.86094311

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.04282126
2MP0001929_abnormal_gametogenesis5.49734280
3MP0008438_abnormal_cutaneous_collagen4.25171575
4MP0008877_abnormal_DNA_methylation3.89179116
5MP0000749_muscle_degeneration3.34580372
6MP0002210_abnormal_sex_determination3.30800799
7MP0002161_abnormal_fertility/fecundity3.30108827
8MP0005670_abnormal_white_adipose3.20796563
9MP0001145_abnormal_male_reproductive2.79863850
10MP0000653_abnormal_sex_gland2.41825465
11MP0001958_emphysema2.38922747
12MP0002653_abnormal_ependyma_morphology2.34556946
13MP0004272_abnormal_basement_membrane2.27656935
14MP0010368_abnormal_lymphatic_system2.22245206
15MP0005503_abnormal_tendon_morphology2.19784035
16MP0004084_abnormal_cardiac_muscle2.11821424
17MP0000751_myopathy2.07296689
18MP0005275_abnormal_skin_tensile2.01319024
19MP0005410_abnormal_fertilization16.7139228
20MP0002127_abnormal_cardiovascular_syste1.97191335
21MP0001542_abnormal_bone_strength1.93157090
22MP0003828_pulmonary_edema1.90969033
23MP0009384_cardiac_valve_regurgitation1.83487961
24MP0000678_abnormal_parathyroid_gland1.79733079
25MP0003705_abnormal_hypodermis_morpholog1.70481740
26MP0002108_abnormal_muscle_morphology1.65677702
27MP0006054_spinal_hemorrhage1.64966624
28MP0005623_abnormal_meninges_morphology1.63105552
29MP0009053_abnormal_anal_canal1.59387077
30MP0005257_abnormal_intraocular_pressure1.59341395
31MP0002249_abnormal_larynx_morphology1.59189638
32MP0004233_abnormal_muscle_weight1.56544618
33MP0003646_muscle_fatigue1.53831879
34MP0005595_abnormal_vascular_smooth1.44627912
35MP0003091_abnormal_cell_migration1.43831601
36MP0002160_abnormal_reproductive_system1.36482735
37MP0000759_abnormal_skeletal_muscle1.32799242
38MP0002933_joint_inflammation1.26543688
39MP0004510_myositis1.26130116
40MP0000733_abnormal_muscle_development1.25744360
41MP0002282_abnormal_trachea_morphology1.23876075
42MP0000767_abnormal_smooth_muscle1.23566741
43MP0004484_altered_response_of1.14157398
44MP0001765_abnormal_ion_homeostasis1.11763922
45MP0002132_abnormal_respiratory_system1.09327553
46MP0001984_abnormal_olfaction1.07847207
47MP0005620_abnormal_muscle_contractility1.05155127
48MP0004883_abnormal_blood_vessel1.04305693
49MP0004270_analgesia1.01249494
50MP0005164_abnormal_response_to0.97335497
51MP0003385_abnormal_body_wall0.94767459
52MP0001879_abnormal_lymphatic_vessel0.93702677
53MP0003718_maternal_effect0.90470823
54MP0009046_muscle_twitch0.90132084
55MP0004087_abnormal_muscle_fiber0.90113426
56MP0002234_abnormal_pharynx_morphology0.88481651
57MP0000049_abnormal_middle_ear0.88306116
58MP0005395_other_phenotype0.87405781
59MP0002332_abnormal_exercise_endurance0.87307347
60MP0000750_abnormal_muscle_regeneration0.87169758
61MP0002168_other_aberrant_phenotype0.86451351
62MP0005023_abnormal_wound_healing0.84230612
63MP0005647_abnormal_sex_gland0.83323894
64MP0002972_abnormal_cardiac_muscle0.82804467
65MP0005330_cardiomyopathy0.82297557
66MP0001486_abnormal_startle_reflex0.80724263
67MP0000467_abnormal_esophagus_morphology0.80572474
68MP0000230_abnormal_systemic_arterial0.79461294
69MP0008058_abnormal_DNA_repair0.77466674
70MP0000249_abnormal_blood_vessel0.77344177
71MP0000163_abnormal_cartilage_morphology0.74760351
72MP0000762_abnormal_tongue_morphology0.74572128
73MP0003115_abnormal_respiratory_system0.74460857
74MP0002115_abnormal_skeleton_extremities0.73948340
75MP0003878_abnormal_ear_physiology0.71641539
76MP0005377_hearing/vestibular/ear_phenot0.71641539
77MP0005083_abnormal_biliary_tract0.71479467
78MP0005508_abnormal_skeleton_morphology0.70982007
79MP0005166_decreased_susceptibility_to0.70358421
80MP0008995_early_reproductive_senescence0.69962921
81MP0002896_abnormal_bone_mineralization0.69257099
82MP0002932_abnormal_joint_morphology0.67413445
83MP0002133_abnormal_respiratory_system0.66672699
84MP0005388_respiratory_system_phenotype0.66672699
85MP0005389_reproductive_system_phenotype0.66379346
86MP0009764_decreased_sensitivity_to0.66248278
87MP0005369_muscle_phenotype0.66078403
88MP0004145_abnormal_muscle_electrophysio0.65869568
89MP0005390_skeleton_phenotype0.64700545
90MP0005171_absent_coat_pigmentation0.64124108
91MP0005666_abnormal_adipose_tissue0.63854459
92MP0010386_abnormal_urinary_bladder0.63458089
93MP0010030_abnormal_orbit_morphology0.62887538
94MP0003448_altered_tumor_morphology0.62884294
95MP0001614_abnormal_blood_vessel0.60594548
96MP0001533_abnormal_skeleton_physiology0.60127672
97MP0001853_heart_inflammation0.59407495
98MP0003011_delayed_dark_adaptation0.58503983
99MP0008775_abnormal_heart_ventricle0.58333538
100MP0003172_abnormal_lysosome_physiology0.57386019
101MP0001299_abnormal_eye_distance/0.56794795
102MP0000747_muscle_weakness0.56334404
103MP0005636_abnormal_mineral_homeostasis0.54473521
104MP0002102_abnormal_ear_morphology0.53434806
105MP0003329_amyloid_beta_deposits0.46635632
106MP0001324_abnormal_eye_pigmentation0.46600925
107MP0002269_muscular_atrophy0.45686868
108MP0004036_abnormal_muscle_relaxation0.45126986
109MP0001764_abnormal_homeostasis0.45040713
110MP0003699_abnormal_female_reproductive0.43939928
111MP0001293_anophthalmia0.43854846
112MP0000534_abnormal_ureter_morphology0.43423840
113MP0002736_abnormal_nociception_after0.42531074
114MP0009115_abnormal_fat_cell0.41837577
115MP0000358_abnormal_cell_content/0.41692541
116MP0004133_heterotaxia0.40722412
117MP0005551_abnormal_eye_electrophysiolog0.40037026
118MP0003950_abnormal_plasma_membrane0.39761004
119MP0005253_abnormal_eye_physiology0.38661754
120MP0010094_abnormal_chromosome_stability0.38605419
121MP0005397_hematopoietic_system_phenotyp0.38037483
122MP0001545_abnormal_hematopoietic_system0.38037483
123MP0009278_abnormal_bone_marrow0.37002977
124MP0001727_abnormal_embryo_implantation0.36085234
125MP0003942_abnormal_urinary_system0.33786870
126MP0002928_abnormal_bile_duct0.32820809
127MP0005423_abnormal_somatic_nervous0.32593474
128MP0001348_abnormal_lacrimal_gland0.31641475
129MP0003111_abnormal_nucleus_morphology0.31187068
130MP0002295_abnormal_pulmonary_circulatio0.31034064
131MP0000569_abnormal_digit_pigmentation0.30599856
132MP0002971_abnormal_brown_adipose0.30034380
133MP0005391_vision/eye_phenotype0.29980091
134MP0004019_abnormal_vitamin_homeostasis0.29806163
135MP0000604_amyloidosis0.29707839
136MP0003879_abnormal_hair_cell0.28584300
137MP0004742_abnormal_vestibular_system0.26857731
138MP0003861_abnormal_nervous_system0.26178437
139MP0010307_abnormal_tumor_latency0.26140068
140MP0001986_abnormal_taste_sensitivity0.25285418
141MP0003633_abnormal_nervous_system0.24179173
142MP0003948_abnormal_gas_homeostasis0.23815312
143MP0001119_abnormal_female_reproductive0.23707156
144MP0004811_abnormal_neuron_physiology0.22684584
145MP0006036_abnormal_mitochondrial_physio0.22013863
146MP0002169_no_abnormal_phenotype0.21621952
147MP0002152_abnormal_brain_morphology0.21556618
148MP0002873_normal_phenotype0.21304086
149MP0003787_abnormal_imprinting0.21209556
150MP0001968_abnormal_touch/_nociception0.20491270
151MP0002405_respiratory_system_inflammati0.19511105
152MP0003631_nervous_system_phenotype0.18742749
153MP0001730_embryonic_growth_arrest0.18659060
154MP0005375_adipose_tissue_phenotype0.18636420
155MP0006035_abnormal_mitochondrial_morpho0.16611570
156MP0002796_impaired_skin_barrier0.16067811
157MP0003936_abnormal_reproductive_system0.15988809
158MP0003045_fibrosis0.15878290
159MP0002092_abnormal_eye_morphology0.15492045
160MP0003786_premature_aging0.15395418
161MP0004808_abnormal_hematopoietic_stem0.14782702
162MP0001661_extended_life_span0.14473798
163MP0001270_distended_abdomen0.14325291
164MP0005451_abnormal_body_composition0.14299578
165MP0001849_ear_inflammation0.12939742
166MP0000001_mammalian_phenotype0.12799631
167MP0002254_reproductive_system_inflammat0.12028392
168MP0000313_abnormal_cell_death0.11797329
169MP0002084_abnormal_developmental_patter0.11589082
170MP0008569_lethality_at_weaning0.11096519
171MP0000462_abnormal_digestive_system0.10944301
172MP0003959_abnormal_lean_body0.10869659
173MP0008057_abnormal_DNA_replication0.10846917
174MP0003279_aneurysm0.10597641

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.47410432
2Abnormal respiratory epithelium morphology (HP:0012253)9.47410432
3Abnormal respiratory motile cilium physiology (HP:0012261)9.44732795
4Rhinitis (HP:0012384)7.63923347
5Abnormal ciliary motility (HP:0012262)7.48983881
6Chronic bronchitis (HP:0004469)7.27701797
7Infertility (HP:0000789)6.99531513
8Nasal polyposis (HP:0100582)6.52679273
9Type 2 muscle fiber atrophy (HP:0003554)6.40934512
10Popliteal pterygium (HP:0009756)6.08639037
11Muscle fiber atrophy (HP:0100295)5.96134393
12Abnormality of the nasal mucosa (HP:0000433)5.35965961
13Abnormality of placental membranes (HP:0011409)5.08274996
14Amniotic constriction ring (HP:0009775)5.08274996
15Male infertility (HP:0003251)4.99487781
16Bronchitis (HP:0012387)4.67322346
17Bronchiectasis (HP:0002110)4.55724225
18Weak cry (HP:0001612)4.31441505
19Nephronophthisis (HP:0000090)4.08944061
20Distal lower limb muscle weakness (HP:0009053)4.04643511
21Calf muscle hypertrophy (HP:0008981)3.93979806
22Premature rupture of membranes (HP:0001788)3.92596384
23Severe visual impairment (HP:0001141)3.90327181
24Protrusio acetabuli (HP:0003179)3.73776068
25Round ear (HP:0100830)3.67394686
26Abnormal spermatogenesis (HP:0008669)3.66082211
27Muscle hypertrophy of the lower extremities (HP:0008968)3.61414162
28Ulnar deviation of the wrist (HP:0003049)3.59224155
29Aortic aneurysm (HP:0004942)3.44582024
30Gowers sign (HP:0003391)3.32094255
31Recurrent sinusitis (HP:0011108)3.31938698
32Recurrent otitis media (HP:0000403)3.30767523
33Malignant hyperthermia (HP:0002047)3.28089493
34Aortic dissection (HP:0002647)3.17696276
35Fetal akinesia sequence (HP:0001989)3.16812964
36Aplasia of the musculature (HP:0100854)3.08417372
37Type 1 muscle fiber predominance (HP:0003803)3.05647987
38Abnormality of the renal medulla (HP:0100957)3.05636474
39Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.94514435
40Recurrent bronchitis (HP:0002837)2.93736045
41Bony spicule pigmentary retinopathy (HP:0007737)2.92781846
42Hyporeflexia of lower limbs (HP:0002600)2.87257305
43Attenuation of retinal blood vessels (HP:0007843)2.81912247
44Impulsivity (HP:0100710)2.81326560
45Vascular tortuosity (HP:0004948)2.79468142
46Soft skin (HP:0000977)2.76955773
47Thin ribs (HP:0000883)2.75753933
48Arterial tortuosity (HP:0005116)2.72044468
49Tubulointerstitial nephritis (HP:0001970)2.71385683
50Atrophic scars (HP:0001075)2.65612092
51Resting tremor (HP:0002322)2.64758099
52Abnormality of the left ventricular outflow tract (HP:0011103)2.61412886
53Subaortic stenosis (HP:0001682)2.61412886
54Abnormality of midbrain morphology (HP:0002418)2.59088684
55Molar tooth sign on MRI (HP:0002419)2.59088684
56Muscle fiber inclusion bodies (HP:0100299)2.56940920
57Hypoplastic heart (HP:0001961)2.55409523
58Chronic hepatic failure (HP:0100626)2.55299781
59Follicular hyperkeratosis (HP:0007502)2.55083981
60Tubular atrophy (HP:0000092)2.52560634
61Pterygium (HP:0001059)2.48435759
62Abnormality of the costochondral junction (HP:0000919)2.47683604
63Nemaline bodies (HP:0003798)2.46611128
64Cholecystitis (HP:0001082)2.36539310
65Abnormal gallbladder physiology (HP:0012438)2.36539310
66Medial flaring of the eyebrow (HP:0010747)2.36166643
67Exercise-induced muscle cramps (HP:0003710)2.35869891
68Tubulointerstitial abnormality (HP:0001969)2.31360513
69Potter facies (HP:0002009)2.30854201
70Facial shape deformation (HP:0011334)2.30854201
71Hypoplasia of the thymus (HP:0000778)2.30702779
72Hypoplastic ischia (HP:0003175)2.28531931
73Gonadotropin excess (HP:0000837)2.25694512
74Abnormal rod and cone electroretinograms (HP:0008323)2.25590828
75Neonatal short-limb short stature (HP:0008921)2.25432870
76Azoospermia (HP:0000027)2.25417814
77Abnormality of the calf musculature (HP:0001430)2.24681405
78Spinal rigidity (HP:0003306)2.21887678
79Neck muscle weakness (HP:0000467)2.21144443
80Muscle stiffness (HP:0003552)2.20223673
81Bradycardia (HP:0001662)2.16414676
82Distal arthrogryposis (HP:0005684)2.15979759
83Abnormality of the ischium (HP:0003174)2.15322769
84Calcaneovalgus deformity (HP:0001848)2.13705509
85Dyschromatopsia (HP:0007641)2.12420597
86Myotonia (HP:0002486)2.12106875
87Sudden death (HP:0001699)2.09627859
88Enlarged epiphyses (HP:0010580)2.07325312
89Primary atrial arrhythmia (HP:0001692)2.05373196
90Areflexia of lower limbs (HP:0002522)2.04701776
91Cone-rod dystrophy (HP:0000548)2.02923088
92Deformed tarsal bones (HP:0008119)2.00636306
93Metaphyseal dysplasia (HP:0100255)2.00282400
94Dynein arm defect of respiratory motile cilia (HP:0012255)13.3028295
95Absent/shortened dynein arms (HP:0200106)13.3028295
96Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.0648711
97Spastic tetraparesis (HP:0001285)1.99831594
98Atrial fibrillation (HP:0005110)1.98106337
99Increased corneal curvature (HP:0100692)1.97524251
100Keratoconus (HP:0000563)1.97524251
101Decreased central vision (HP:0007663)1.96693371
102Epiphyseal dysplasia (HP:0002656)1.94682975
103Choroideremia (HP:0001139)1.94406329
104Supraventricular tachycardia (HP:0004755)1.93442661
105Ankle contracture (HP:0006466)1.92598782
106Absent phalangeal crease (HP:0006109)1.92461091
107Supraventricular arrhythmia (HP:0005115)1.92034732
108Peritonitis (HP:0002586)1.91219524
109Nonprogressive disorder (HP:0003680)1.88574694
110Tubulointerstitial fibrosis (HP:0005576)1.85649264
111Postural instability (HP:0002172)1.85237047
112Mitral stenosis (HP:0001718)1.83157291
113Hypoalphalipoproteinemia (HP:0003233)1.81619970
114Akinesia (HP:0002304)1.80935945
115Short nail (HP:0001799)1.80701682
116Bladder diverticulum (HP:0000015)1.80251554
117Aplasia/Hypoplasia involving the musculature (HP:0001460)1.79688261
118Spondylolisthesis (HP:0003302)1.78842774
119Hyperextensible skin (HP:0000974)1.77523482
120Stage 5 chronic kidney disease (HP:0003774)1.75213742
121Abnormal biliary tract physiology (HP:0012439)1.74629418
122Bile duct proliferation (HP:0001408)1.74629418
123Postaxial foot polydactyly (HP:0001830)1.74560667
124Polydipsia (HP:0001959)1.73120339
125Abnormal drinking behavior (HP:0030082)1.73120339
126Neurofibrillary tangles (HP:0002185)1.72377793
127Hemorrhage of the eye (HP:0011885)1.72367791
128Congenital hepatic fibrosis (HP:0002612)1.70825557
129Heterotopia (HP:0002282)1.70373890
130Congenital malformation of the right heart (HP:0011723)1.66674008
131Double outlet right ventricle (HP:0001719)1.66674008
132Abnormality of dentin (HP:0010299)1.62722792
133Hypoplasia of the capital femoral epiphysis (HP:0003090)1.59645939
134Chronic sinusitis (HP:0011109)1.59476842
135Aplasia/Hypoplasia of the lens (HP:0008063)1.57367641
136Abnormality of renal excretion (HP:0011036)1.55892571
137Bell-shaped thorax (HP:0001591)1.52975002
138Short ribs (HP:0000773)1.52551168
139Abnormality of permanent molar morphology (HP:0011071)1.48765561
140Abnormality of the dental root (HP:0006486)1.48765561
141Taurodontia (HP:0000679)1.48765561
142Oculomotor apraxia (HP:0000657)1.47453092
143Decreased electroretinogram (ERG) amplitude (HP:0000654)1.46694323
144Abnormality of the renal cortex (HP:0011035)1.46442269
145Abnormality of the dental pulp (HP:0006479)1.45226555
146Renal dysplasia (HP:0000110)1.42387838
147Sensory axonal neuropathy (HP:0003390)1.41769950
148Easy fatigability (HP:0003388)1.40589976
149Postaxial hand polydactyly (HP:0001162)1.39746865
150Abnormality of molar morphology (HP:0011070)1.38577134
151Abnormality of molar (HP:0011077)1.38577134
152Cerebral inclusion bodies (HP:0100314)1.36950536
153Fibular hypoplasia (HP:0003038)1.36691162
154Cystic liver disease (HP:0006706)1.36648281
155Facial cleft (HP:0002006)1.36474443
156Bundle branch block (HP:0011710)1.35491328
157Deformed sella turcica (HP:0002681)1.33951983
158Hemiparesis (HP:0001269)1.33811166
159Abnormal urine output (HP:0012590)1.31691572
160Exercise-induced myalgia (HP:0003738)1.29996443
161Congenital primary aphakia (HP:0007707)1.29649235
162Gait imbalance (HP:0002141)1.29588882
163Asymmetric septal hypertrophy (HP:0001670)1.29351230
164Fatigable weakness (HP:0003473)1.28736765
165Abnormality of the neuromuscular junction (HP:0003398)1.28736765
166Loss of speech (HP:0002371)1.27311068
167Pancreatic fibrosis (HP:0100732)1.27195228
168Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.24054537
169Absent epiphyses (HP:0010577)1.24054537
170Constricted visual fields (HP:0001133)1.23161927
171Hypercholesterolemia (HP:0003124)1.23109896
172True hermaphroditism (HP:0010459)1.19554941
173Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.18075676
174Nephropathy (HP:0000112)1.14516722
175Broad distal phalanx of finger (HP:0009836)1.14455961
176Abnormality of saccadic eye movements (HP:0000570)1.14309441
177Absent frontal sinuses (HP:0002688)1.13910396
178Short thorax (HP:0010306)1.12869663
179Short femoral neck (HP:0100864)1.12530323
180Cerebellar dysplasia (HP:0007033)1.12412407
181Myoglobinuria (HP:0002913)1.11724588
182Truncal obesity (HP:0001956)1.10367795

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.67943242
2PDK37.67943242
3TESK16.76078023
4PRKD35.82222790
5PDK24.99667498
6ICK4.90884407
7DDR24.26933038
8PIK3CG3.49969014
9ARAF3.09594996
10MAP4K22.97444234
11MOS2.74179259
12PLK22.50916009
13KSR22.46934984
14MAP3K92.39209912
15LATS22.34227209
16INSRR2.25548567
17PTK2B2.24513471
18WNK42.20543215
19STK392.06394392
20MYLK1.91617549
21STK381.90495491
22DYRK1B1.76759381
23PNCK1.75597757
24MAP3K131.66736374
25NEK21.53754108
26PAK61.34946181
27TGFBR21.29595254
28PDK11.19203795
29BRD41.17573889
30RIPK11.17102456
31MST1R1.12132281
32CDK81.08744605
33DYRK31.01784734
34MAPK150.95819243
35RAF10.93918135
36TIE10.91871962
37LATS10.88001838
38TYRO30.84825007
39WNK10.83985949
40RPS6KA20.80367601
41ABL20.79862246
42PDPK10.77927891
43NEK90.77913352
44IRAK10.77908110
45EEF2K0.77627661
46RIPK40.75713673
47ROCK10.74022352
48KIT0.71105079
49MAP2K20.71050586
50CDK70.69673493
51STK30.69625864
52MAP3K80.68558424
53TESK20.67647611
54AKT30.66898980
55PASK0.66753329
56DMPK0.63071395
57CDK190.62554848
58KSR10.61667368
59BMPR20.61154124
60CHEK20.58625211
61TNIK0.58465198
62CCNB10.57470764
63TTK0.56833661
64MAPK70.56606838
65FLT30.56401415
66LIMK10.52830947
67MAP2K60.51276875
68MAP3K30.50645027
69NTRK20.49743841
70MAP3K10.49672252
71PINK10.49320324
72CAMK1G0.47357575
73OBSCN0.46411431
74IRAK20.46045537
75PAK10.44616992
76MAP2K10.43306067
77LMTK20.43223021
78BLK0.42797972
79PDGFRA0.41921132
80MUSK0.40522293
81STK38L0.38791530
82MAP3K100.37014352
83CHEK10.36575303
84MET0.34706996
85IKBKB0.33372237
86PRKCG0.33256161
87ACVR1B0.32386208
88MAPK10.30960537
89PRKD20.30752719
90ERBB40.30724266
91PTK20.30483020
92PAK20.30148279
93MAP2K30.30018220
94PAK40.29012049
95NEK60.28958233
96PIK3CA0.28674164
97RPS6KC10.28533762
98RPS6KL10.28533762
99MAP3K20.28142555
100STK160.28001742
101MARK20.27743198
102MAPKAPK50.27575450
103MTOR0.26963264
104MAPK110.25554455
105ATM0.24367758
106PRKAA10.22209572
107CAMKK10.21979748
108PBK0.21689300
109ILK0.21413267
110BRSK20.21257259
111PRKCZ0.20980370
112RPS6KA60.20599038
113IGF1R0.20064330
114ATR0.19674835
115ROCK20.19541359
116WEE10.18985828
117PRKCQ0.18868412
118RPS6KB10.17326967
119PKN10.17121566
120DAPK30.16279114
121CDK150.15337031
122RPS6KA10.13024621
123STK110.12557358
124CDK180.12170171
125PLK40.11633007
126CDK11A0.11141674
127CDK120.10164284
128PLK10.09598802
129PRKG20.09266393
130STK100.09112004
131PIM10.08855885
132GSK3B0.06843570
133CDK140.06599652
134EPHB10.06198658
135CSNK2A10.06136977
136PRKCD0.05828668
137BRSK10.05066886
138CDK60.03769045
139PRKG10.03449875
140MARK30.02952187
141AURKA0.02915912
142PRKACG0.02861994
143PRKCB0.02509080
144CSF1R0.02484255
145CDK20.01761542
146CSNK1D0.01642399
147MAPK80.01540866
148CAMK2A0.01404619
149EGFR0.01356367
150BRAF0.01261240
151CSNK2A20.00778580
152PRKCA0.00775592
153CDK40.00731289
154PDGFRB0.00516153
155CDK10.00415006
156PRKACB-0.0483892
157MAP3K4-0.0431307
158RPS6KA3-0.0339064
159PRKACA-0.0302522
160BMPR1B-0.0291715
161CLK1-0.0157036
162ZAP70-0.0114812
163CDC7-0.0090208
164YES1-0.0082597

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.58071198
2Fatty acid biosynthesis_Homo sapiens_hsa000614.89821460
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.38586344
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.31208439
5Linoleic acid metabolism_Homo sapiens_hsa005913.23398518
6Vitamin B6 metabolism_Homo sapiens_hsa007503.19643301
7Pyruvate metabolism_Homo sapiens_hsa006203.07672451
8Viral myocarditis_Homo sapiens_hsa054162.88412530
9Olfactory transduction_Homo sapiens_hsa047402.85162517
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.76193963
11Carbohydrate digestion and absorption_Homo sapiens_hsa049732.54481889
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.49115750
13Glucagon signaling pathway_Homo sapiens_hsa049222.48596150
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.37484173
15Basal transcription factors_Homo sapiens_hsa030222.32102780
16Propanoate metabolism_Homo sapiens_hsa006402.30102336
17ECM-receptor interaction_Homo sapiens_hsa045122.22479490
18Allograft rejection_Homo sapiens_hsa053302.08983242
19Focal adhesion_Homo sapiens_hsa045102.08575425
20Graft-versus-host disease_Homo sapiens_hsa053322.03545317
21Glycerolipid metabolism_Homo sapiens_hsa005612.02487252
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.95065812
23Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.94920059
24PPAR signaling pathway_Homo sapiens_hsa033201.91425836
25Selenocompound metabolism_Homo sapiens_hsa004501.84690510
26Glycerophospholipid metabolism_Homo sapiens_hsa005641.84503341
27Dilated cardiomyopathy_Homo sapiens_hsa054141.83901493
28Pertussis_Homo sapiens_hsa051331.81811939
29Autoimmune thyroid disease_Homo sapiens_hsa053201.80743324
30Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.76471363
31Fructose and mannose metabolism_Homo sapiens_hsa000511.71612773
32Type I diabetes mellitus_Homo sapiens_hsa049401.65610078
33Dorso-ventral axis formation_Homo sapiens_hsa043201.64676861
34Oocyte meiosis_Homo sapiens_hsa041141.55709079
35Fat digestion and absorption_Homo sapiens_hsa049751.55535908
36Ether lipid metabolism_Homo sapiens_hsa005651.54276316
37Pentose phosphate pathway_Homo sapiens_hsa000301.53395397
38Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.53100359
39Mineral absorption_Homo sapiens_hsa049781.53083568
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.49889445
41Amphetamine addiction_Homo sapiens_hsa050311.49248390
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.40570536
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.38813234
44Fatty acid degradation_Homo sapiens_hsa000711.34402299
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.33514553
46Phagosome_Homo sapiens_hsa041451.32811710
47Fatty acid metabolism_Homo sapiens_hsa012121.32769261
48Gap junction_Homo sapiens_hsa045401.27307467
49Cardiac muscle contraction_Homo sapiens_hsa042601.27208932
50Fanconi anemia pathway_Homo sapiens_hsa034601.25474764
51Antigen processing and presentation_Homo sapiens_hsa046121.23815610
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22721575
53Carbon metabolism_Homo sapiens_hsa012001.17361831
54Hedgehog signaling pathway_Homo sapiens_hsa043401.14072895
55Regulation of actin cytoskeleton_Homo sapiens_hsa048101.05089133
56Renin secretion_Homo sapiens_hsa049241.04940740
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99314086
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98918685
59Proteoglycans in cancer_Homo sapiens_hsa052050.98736594
60Glutathione metabolism_Homo sapiens_hsa004800.97462278
61Purine metabolism_Homo sapiens_hsa002300.96688703
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.95624772
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93989305
64Collecting duct acid secretion_Homo sapiens_hsa049660.92973132
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.92662221
66Arachidonic acid metabolism_Homo sapiens_hsa005900.92384944
67mRNA surveillance pathway_Homo sapiens_hsa030150.91862506
68Arginine and proline metabolism_Homo sapiens_hsa003300.91251228
69TGF-beta signaling pathway_Homo sapiens_hsa043500.90932423
70Leishmaniasis_Homo sapiens_hsa051400.88561329
71Asthma_Homo sapiens_hsa053100.88478408
72Huntingtons disease_Homo sapiens_hsa050160.88434752
73Bladder cancer_Homo sapiens_hsa052190.88044471
74Amoebiasis_Homo sapiens_hsa051460.87343614
75Malaria_Homo sapiens_hsa051440.83740179
76Insulin secretion_Homo sapiens_hsa049110.80778480
77Chemical carcinogenesis_Homo sapiens_hsa052040.77772447
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76715091
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75679641
80Butanoate metabolism_Homo sapiens_hsa006500.75611468
81Estrogen signaling pathway_Homo sapiens_hsa049150.75145660
82Rheumatoid arthritis_Homo sapiens_hsa053230.74477540
83RNA transport_Homo sapiens_hsa030130.71233674
84Bile secretion_Homo sapiens_hsa049760.70961256
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70393992
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68852769
87Thyroid hormone synthesis_Homo sapiens_hsa049180.68611085
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67248076
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67200942
90Renin-angiotensin system_Homo sapiens_hsa046140.65856824
91Oxytocin signaling pathway_Homo sapiens_hsa049210.65078376
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64566564
93Biosynthesis of amino acids_Homo sapiens_hsa012300.63924851
94Long-term potentiation_Homo sapiens_hsa047200.62741470
95Systemic lupus erythematosus_Homo sapiens_hsa053220.62725809
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62371909
97Legionellosis_Homo sapiens_hsa051340.62290935
98Staphylococcus aureus infection_Homo sapiens_hsa051500.61822679
99Adherens junction_Homo sapiens_hsa045200.60666414
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60611201
101ABC transporters_Homo sapiens_hsa020100.60352076
102Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58907819
103Salmonella infection_Homo sapiens_hsa051320.57325129
104Pancreatic secretion_Homo sapiens_hsa049720.56953878
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.54884466
106Endocytosis_Homo sapiens_hsa041440.54416852
107Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53701449
108MAPK signaling pathway_Homo sapiens_hsa040100.52642717
109Calcium signaling pathway_Homo sapiens_hsa040200.49861258
110Salivary secretion_Homo sapiens_hsa049700.48640902
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.48638402
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.48467859
113Platelet activation_Homo sapiens_hsa046110.48176722
114AMPK signaling pathway_Homo sapiens_hsa041520.47639999
115Protein digestion and absorption_Homo sapiens_hsa049740.47451917
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46790205
117African trypanosomiasis_Homo sapiens_hsa051430.46220566
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44874809
119Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43709727
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42904575
121Intestinal immune network for IgA production_Homo sapiens_hsa046720.42775245
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42500755
123Tight junction_Homo sapiens_hsa045300.42341963
124Inositol phosphate metabolism_Homo sapiens_hsa005620.42316051
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42160219
126Gastric acid secretion_Homo sapiens_hsa049710.42009774
127Osteoclast differentiation_Homo sapiens_hsa043800.41995887
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41986653
129Taste transduction_Homo sapiens_hsa047420.37974323
130Tuberculosis_Homo sapiens_hsa051520.36762558
131Synaptic vesicle cycle_Homo sapiens_hsa047210.36008467
132Hippo signaling pathway_Homo sapiens_hsa043900.34846273
133Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34298232
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.33229482
135Metabolic pathways_Homo sapiens_hsa011000.31163320
136VEGF signaling pathway_Homo sapiens_hsa043700.30967542
137cAMP signaling pathway_Homo sapiens_hsa040240.30618173
138Apoptosis_Homo sapiens_hsa042100.30043169
139Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29224883
140Alcoholism_Homo sapiens_hsa050340.27789181
141Pyrimidine metabolism_Homo sapiens_hsa002400.26731430
142Basal cell carcinoma_Homo sapiens_hsa052170.26375236
143Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.25669422
144Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23934081
145Measles_Homo sapiens_hsa051620.22537626
146Cocaine addiction_Homo sapiens_hsa050300.21236886
147Toxoplasmosis_Homo sapiens_hsa051450.17790627
148Circadian entrainment_Homo sapiens_hsa047130.17446626
149B cell receptor signaling pathway_Homo sapiens_hsa046620.16086740
150Sulfur metabolism_Homo sapiens_hsa009200.15191346
151Wnt signaling pathway_Homo sapiens_hsa043100.14096573
152Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.11190697
153Influenza A_Homo sapiens_hsa051640.10575748
154Viral carcinogenesis_Homo sapiens_hsa052030.10202155
155HIF-1 signaling pathway_Homo sapiens_hsa040660.09962493
156Type II diabetes mellitus_Homo sapiens_hsa049300.09311433

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