CCKAR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cobalamin metabolic process (GO:0009235)9.11053703
2sequestering of extracellular ligand from receptor (GO:0035581)8.95462844
3keratan sulfate catabolic process (GO:0042340)7.61535438
4transcytosis (GO:0045056)7.36905407
5response to parathyroid hormone (GO:0071107)7.08150031
6chondrocyte proliferation (GO:0035988)6.82581641
7cholesterol catabolic process (GO:0006707)6.74772876
8sterol catabolic process (GO:0016127)6.74772876
9peptidyl-proline hydroxylation (GO:0019511)6.73721356
10cysteine metabolic process (GO:0006534)6.70570504
11intestinal absorption (GO:0050892)6.53080300
12regulation of phospholipase A2 activity (GO:0032429)6.39209306
13negative regulation of digestive system process (GO:0060457)6.36948084
14branched-chain amino acid catabolic process (GO:0009083)6.31998178
15glycolipid catabolic process (GO:0019377)5.90691785
16valine metabolic process (GO:0006573)5.89946644
17branched-chain amino acid metabolic process (GO:0009081)5.89464857
18membrane lipid catabolic process (GO:0046466)5.70156804
19peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)5.58460304
20ceramide catabolic process (GO:0046514)5.36774755
21protein hydroxylation (GO:0018126)5.21928580
22extracellular regulation of signal transduction (GO:1900115)5.14476495
23extracellular negative regulation of signal transduction (GO:1900116)5.14476495
24cellular modified amino acid catabolic process (GO:0042219)5.12283761
25mitochondrial calcium ion transport (GO:0006851)4.95117415
26proline biosynthetic process (GO:0006561)4.93777992
27mesenchymal cell differentiation involved in kidney development (GO:0072161)4.93695481
28mesenchymal cell differentiation involved in renal system development (GO:2001012)4.93695481
29homocysteine metabolic process (GO:0050667)4.87729196
30collagen fibril organization (GO:0030199)4.87116012
31aspartate family amino acid catabolic process (GO:0009068)4.82710285
32COPI coating of Golgi vesicle (GO:0048205)4.75921224
33Golgi transport vesicle coating (GO:0048200)4.75921224
34enteric nervous system development (GO:0048484)4.64979306
35mesenchymal-epithelial cell signaling (GO:0060638)4.64172322
36cell migration involved in heart development (GO:0060973)4.60096884
37bone trabecula formation (GO:0060346)4.55363870
38diaphragm development (GO:0060539)4.48214680
39negative regulation of biomineral tissue development (GO:0070168)4.40785407
40leukotriene biosynthetic process (GO:0019370)4.39989615
41zinc ion transport (GO:0006829)4.34978818
42serine family amino acid biosynthetic process (GO:0009070)4.33464732
43negative regulation of bone mineralization (GO:0030502)4.31135618
44proline metabolic process (GO:0006560)4.27753049
45cell differentiation involved in metanephros development (GO:0072202)4.26106849
46activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.25539295
47lung vasculature development (GO:0060426)4.21754915
48ganglion development (GO:0061548)4.19652076
49positive regulation of heat generation (GO:0031652)4.17666407
50neuron projection extension involved in neuron projection guidance (GO:1902284)4.17233091
51axon extension involved in axon guidance (GO:0048846)4.17233091
52dermatan sulfate biosynthetic process (GO:0030208)4.14171568
53intestinal epithelial cell development (GO:0060576)4.07317502
54mitochondrion distribution (GO:0048311)4.05216288
55negative regulation of BMP signaling pathway (GO:0030514)4.04766429
56regulation of fever generation (GO:0031620)4.03521708
57positive regulation of nuclease activity (GO:0032075)4.03136528
58lysine catabolic process (GO:0006554)4.02171519
59lysine metabolic process (GO:0006553)4.02171519
60cell aggregation (GO:0098743)4.01009305
61cartilage condensation (GO:0001502)4.01009305
62response to endoplasmic reticulum stress (GO:0034976)3.99117972
63skeletal muscle organ development (GO:0060538)3.95089119
64protein maturation by protein folding (GO:0022417)3.87395931
65type B pancreatic cell proliferation (GO:0044342)3.83751179
66activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.83159833
67dermatan sulfate metabolic process (GO:0030205)3.82164688
68chondrocyte development (GO:0002063)3.81716980
69respiratory tube development (GO:0030323)3.81617153
70endoplasmic reticulum unfolded protein response (GO:0030968)3.78705720
71coenzyme catabolic process (GO:0009109)3.78410222
72extracellular matrix assembly (GO:0085029)3.78310195
73cartilage morphogenesis (GO:0060536)3.75250923
74regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.72671394
75negative regulation of osteoblast proliferation (GO:0033689)3.72477708
76steroid catabolic process (GO:0006706)3.72431778
77ossification (GO:0001503)3.68618157
78serine family amino acid metabolic process (GO:0009069)3.67318468
79cellular response to unfolded protein (GO:0034620)3.67285094
80regulation of nuclease activity (GO:0032069)3.63612460
81L-phenylalanine catabolic process (GO:0006559)3.61438459
82erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.61438459
83trivalent inorganic anion homeostasis (GO:0072506)3.61118787
84phosphate ion homeostasis (GO:0055062)3.61118787
85maintenance of protein localization in organelle (GO:0072595)3.60522760
86negative regulation of dendrite morphogenesis (GO:0050774)3.60222190
87signal peptide processing (GO:0006465)3.58123463
88embryonic viscerocranium morphogenesis (GO:0048703)3.57130878
89neutrophil mediated immunity (GO:0002446)3.57065552
90blood vessel maturation (GO:0001955)3.56973460
91regulation of bone mineralization (GO:0030500)3.56317047
92ER overload response (GO:0006983)3.55265062
93biomineral tissue development (GO:0031214)3.54253728
94negative regulation of ossification (GO:0030279)3.51104942
954-hydroxyproline metabolic process (GO:0019471)3.50360571
96peptide catabolic process (GO:0043171)3.50204270
97myoblast migration (GO:0051451)3.49935316
98extracellular fibril organization (GO:0043206)3.49688918
99ER-nucleus signaling pathway (GO:0006984)3.49512412
100embryonic cranial skeleton morphogenesis (GO:0048701)3.48352997
101L-phenylalanine metabolic process (GO:0006558)3.47442436
102erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.47442436
103cellular response to topologically incorrect protein (GO:0035967)3.47427231
104regulation of biomineral tissue development (GO:0070167)3.46986819
105muscle cell migration (GO:0014812)3.46260873
106smooth muscle tissue development (GO:0048745)3.44639402
107behavioral response to nicotine (GO:0035095)3.44073210
108sphingolipid catabolic process (GO:0030149)3.35493155
109biotin metabolic process (GO:0006768)3.34223317
110endocrine pancreas development (GO:0031018)3.34222118
111polarized epithelial cell differentiation (GO:0030859)3.33978595
112metanephric mesenchyme development (GO:0072075)3.33897694
113cellular protein catabolic process (GO:0044257)3.33237642
114protein heterotrimerization (GO:0070208)3.32771046
115positive regulation of extracellular matrix organization (GO:1903055)3.31877631
116substrate adhesion-dependent cell spreading (GO:0034446)3.30590634
117positive regulation of cardiac muscle cell differentiation (GO:2000727)3.30320959
118endochondral ossification (GO:0001958)3.25592903
119replacement ossification (GO:0036075)3.25592903
120mesenchymal cell differentiation (GO:0048762)3.25130844
121sympathetic nervous system development (GO:0048485)3.21268391
122collagen metabolic process (GO:0032963)3.21253831
123glutamine metabolic process (GO:0006541)3.20861336
124creatine metabolic process (GO:0006600)3.19906278
125substrate-dependent cell migration (GO:0006929)3.16665997
126multicellular organismal metabolic process (GO:0044236)3.16521866
127kidney mesenchyme development (GO:0072074)3.13790955
128regulation of extracellular matrix disassembly (GO:0010715)3.13399020
129regulation of heat generation (GO:0031650)3.13321753
130tongue development (GO:0043586)3.11735403
131dopaminergic neuron differentiation (GO:0071542)3.11516443
132ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.10692177
133COPII vesicle coating (GO:0048208)3.10058636
134paraxial mesoderm development (GO:0048339)3.08562152
135short-chain fatty acid metabolic process (GO:0046459)3.07104506
136positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.07000302
137positive regulation of cell cycle G2/M phase transition (GO:1902751)3.07000302
138icosanoid secretion (GO:0032309)3.06443121
139arachidonic acid secretion (GO:0050482)3.06443121
140multicellular organismal catabolic process (GO:0044243)3.05582618
141lymphangiogenesis (GO:0001946)3.05266928
142regulation of digestive system process (GO:0044058)3.04913731
143aminoglycoside antibiotic metabolic process (GO:0030647)3.04786455
144extracellular matrix organization (GO:0030198)3.04776848
145positive regulation of fibroblast migration (GO:0010763)3.03876998
146tetrapyrrole metabolic process (GO:0033013)3.03806892
147extracellular structure organization (GO:0043062)3.03761915
148antibacterial humoral response (GO:0019731)3.03283999
149negative chemotaxis (GO:0050919)3.02683459
150negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.02030122
151regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.01797311
152pancreas development (GO:0031016)3.01404404
153regulation of transforming growth factor beta2 production (GO:0032909)3.00376124
154positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.99811916
155collagen catabolic process (GO:0030574)2.99203480
156multicellular organismal macromolecule metabolic process (GO:0044259)2.98122990
157regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.96865569
158regulation of chemokine-mediated signaling pathway (GO:0070099)2.94457221
159glomerulus development (GO:0032835)2.94039027
160keratan sulfate biosynthetic process (GO:0018146)2.93025147
161fibril organization (GO:0097435)2.92396130
162protein N-linked glycosylation via asparagine (GO:0018279)2.91248126
163neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.89978208
164chondroitin sulfate catabolic process (GO:0030207)2.89966722
165peptidyl-asparagine modification (GO:0018196)2.89771176
166response to unfolded protein (GO:0006986)2.89278909
167cellular amino acid catabolic process (GO:0009063)2.88059607
168positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.87895142
169embryonic body morphogenesis (GO:0010172)2.87779798
170mesenchyme morphogenesis (GO:0072132)2.86898690
171extracellular matrix disassembly (GO:0022617)2.86727980
172retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.86719110
173glycine transport (GO:0015816)2.86230921
174cell proliferation involved in metanephros development (GO:0072203)2.85601835
175cell redox homeostasis (GO:0045454)2.85459580
176positive regulation of digestive system process (GO:0060456)2.84334310
177L-serine metabolic process (GO:0006563)2.84151908
178pericardium development (GO:0060039)2.83918798
179purinergic nucleotide receptor signaling pathway (GO:0035590)2.82813432
180establishment of apical/basal cell polarity (GO:0035089)2.82805347
181midgut development (GO:0007494)2.81256402
182positive regulation of mesenchymal cell proliferation (GO:0002053)2.80729869
183negative regulation of epidermal cell differentiation (GO:0045605)2.80527761
184sulfur amino acid biosynthetic process (GO:0000097)2.80398605
185lung secretory cell differentiation (GO:0061140)2.79415073
186positive regulation of receptor internalization (GO:0002092)2.77294321
187negative regulation of cell fate commitment (GO:0010454)2.77210494
188insulin-like growth factor receptor signaling pathway (GO:0048009)2.76941229
189regulation of BMP signaling pathway (GO:0030510)2.76865527
190response to topologically incorrect protein (GO:0035966)2.76673200
191bone development (GO:0060348)2.76333249
192GDP-mannose metabolic process (GO:0019673)2.75503630
193regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175)2.75427083
194antimicrobial humoral response (GO:0019730)2.71909510
195intestinal cholesterol absorption (GO:0030299)15.2840298
196exocrine pancreas development (GO:0031017)15.2105293
197* digestion (GO:0007586)12.5444043
198protein retention in ER lumen (GO:0006621)11.1809614
199maintenance of protein localization in endoplasmic reticulum (GO:0035437)10.4149206

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.17691280
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.88771619
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.63124865
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.52173359
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.43934615
6ERG_21242973_ChIP-ChIP_JURKAT_Human3.36139742
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.16011227
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.03673741
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.96518772
10WT1_19549856_ChIP-ChIP_CCG9911_Human2.84860314
11CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.77157036
12* GATA4_25053715_ChIP-Seq_YYC3_Human2.72672170
13SOX2_27498859_Chip-Seq_STOMACH_Mouse2.60091612
14ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.51405896
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.45719865
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.37756742
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.37142774
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.34289105
19ESR2_21235772_ChIP-Seq_MCF-7_Human2.32820155
20BRD4_25478319_ChIP-Seq_HGPS_Human2.30931808
21GATA6_25053715_ChIP-Seq_YYC3_Human2.22851940
22RXR_22158963_ChIP-Seq_LIVER_Mouse2.19641621
23HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.18229560
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.15434860
25PPARA_22158963_ChIP-Seq_LIVER_Mouse2.14950218
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.12828994
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.11546385
28* CJUN_26792858_Chip-Seq_BT549_Human2.10975088
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.09883517
30CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.08476022
31FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.06526460
32RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.04195536
33CDX2_19796622_ChIP-Seq_MESCs_Mouse2.03358215
34RARG_19884340_ChIP-ChIP_MEFs_Mouse2.03128653
35LXR_22158963_ChIP-Seq_LIVER_Mouse1.99289472
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.98272378
37ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.98225974
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.95271656
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.89647078
40CDX2_20551321_ChIP-Seq_CACO-2_Human1.84383956
41SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.83997672
42EP300_21415370_ChIP-Seq_HL-1_Mouse1.82505400
43PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.81336796
44EZH2_22144423_ChIP-Seq_EOC_Human1.80943337
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.79851272
46HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.77259774
47JARID2_20064375_ChIP-Seq_MESCs_Mouse1.76263923
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.75606418
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.74002969
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.69987289
51EGR1_19032775_ChIP-ChIP_M12_Human1.67307933
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66852967
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.66257964
54KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.66040963
55KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.66040963
56KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.66040963
57GATA1_22025678_ChIP-Seq_K562_Human1.62205308
58SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.60082823
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.59786613
60NRF2_20460467_ChIP-Seq_MEFs_Mouse1.59284035
61NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.59284035
62CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.59129067
63TAF15_26573619_Chip-Seq_HEK293_Human1.55912487
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.55056106
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.52965415
66FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.51530003
67RNF2_27304074_Chip-Seq_ESCs_Mouse1.50161888
68GBX2_23144817_ChIP-Seq_PC3_Human1.49848001
69TP53_16413492_ChIP-PET_HCT116_Human1.48584175
70EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.47738446
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47341069
72SMAD4_21799915_ChIP-Seq_A2780_Human1.46674674
73TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44604187
74RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.43341833
75SOX2_20726797_ChIP-Seq_SW620_Human1.43083495
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40085133
77TP53_20018659_ChIP-ChIP_R1E_Mouse1.39798894
78ESET_19884257_ChIP-Seq_ESCs_Mouse1.39032591
79SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.37775250
80ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37193625
81TCF4_18268006_ChIP-ChIP_LS174T_Human1.36016591
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.34856021
83TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34536347
84TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.30011367
85AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.23645994
86RING1B_27294783_Chip-Seq_NPCs_Mouse1.21979692
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21429450
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20847228
89* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19432489
90ISL1_27105846_Chip-Seq_CPCs_Mouse1.18931112
91TP63_19390658_ChIP-ChIP_HaCaT_Human1.18231782
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18084086
93P300_19829295_ChIP-Seq_ESCs_Human1.17888427
94CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.17360535
95PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.16930660
96OCT4_20526341_ChIP-Seq_ESCs_Human1.16082065
97FUS_26573619_Chip-Seq_HEK293_Human1.16006341
98JARID2_20075857_ChIP-Seq_MESCs_Mouse1.15889476
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15729282
100P63_26484246_Chip-Seq_KERATINOCYTES_Human1.15460411
101EGR1_19374776_ChIP-ChIP_THP-1_Human1.14861922
102SA1_27219007_Chip-Seq_ERYTHROID_Human1.14426319
103FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13864289
104NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12287758
105LXR_22292898_ChIP-Seq_THP-1_Human1.10884128
106SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09090150
107FOXA2_19822575_ChIP-Seq_HepG2_Human1.08915494
108CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08871086
109P68_20966046_ChIP-Seq_HELA_Human1.08428947
110TP63_22573176_ChIP-Seq_HFKS_Human1.07176992
111MTF2_20144788_ChIP-Seq_MESCs_Mouse1.06755150
112ZNF274_21170338_ChIP-Seq_K562_Hela1.06325449
113RING1B_27294783_Chip-Seq_ESCs_Mouse1.05819642
114SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05646566
115CBX2_27304074_Chip-Seq_ESCs_Mouse1.05517590
116CREB1_26743006_Chip-Seq_LNCaP_Human1.04966183
117EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04945060
118SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04628296
119E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03986256
120AHR_22903824_ChIP-Seq_MCF-7_Human1.03301051
121* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03281780
122CTCF_27219007_Chip-Seq_Bcells_Human1.03111690
123POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02743878
124NANOG_18555785_Chip-Seq_ESCs_Mouse1.02631324
125FOXA1_25552417_ChIP-Seq_VCAP_Human1.02463403
126GATA3_24758297_ChIP-Seq_MCF-7_Human1.02197936
127SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.01489344
128* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01479423
129TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01291803
130NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01157402
131TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00912928
132ELK4_26923725_Chip-Seq_MESODERM_Mouse0.99791341
133TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99302524
134SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99270653
135TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98954507
136YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98628117
137SMAD3_21741376_ChIP-Seq_EPCs_Human0.98499276
138PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98442329
139EWS_26573619_Chip-Seq_HEK293_Human0.98197704
140ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98063627
141SOX9_26525672_Chip-Seq_HEART_Mouse0.97705351
142TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97454583
143KDM2B_26808549_Chip-Seq_REH_Human0.97177794
144RUNX1_27514584_Chip-Seq_MCF-7_Human0.96457066
145ERA_21632823_ChIP-Seq_H3396_Human0.95746904
146GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95521006
147STAT3_23295773_ChIP-Seq_U87_Human0.95517800
148CHD1_26751641_Chip-Seq_LNCaP_Human0.95466880
149NFE2_27457419_Chip-Seq_LIVER_Mouse0.95403509
150FOXH1_21741376_ChIP-Seq_ESCs_Human0.95270387
151ARNT_22903824_ChIP-Seq_MCF-7_Human0.94909157
152AR_21572438_ChIP-Seq_LNCaP_Human0.94802903
153ERG_20517297_ChIP-Seq_VCAP_Human0.94268775
154SMC1_22415368_ChIP-Seq_MEFs_Mouse0.93770720
155CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93617502
156TAF2_19829295_ChIP-Seq_ESCs_Human0.92568230
157EZH2_18974828_ChIP-Seq_MESCs_Mouse0.92474921
158RNF2_18974828_ChIP-Seq_MESCs_Mouse0.92474921
159PPAR_26484153_Chip-Seq_NCI-H1993_Human0.92191280
160FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91820268
161PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90451730
162* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.86001883
163FOXO3_23340844_ChIP-Seq_DLD1_Human0.85353327
164GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.85123232
165RACK7_27058665_Chip-Seq_MCF-7_Human0.84043961
166SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.83725389
167IRF1_19129219_ChIP-ChIP_H3396_Human0.83457761
168OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.83363372
169P53_21459846_ChIP-Seq_SAOS-2_Human0.83093261
170SUZ12_27294783_Chip-Seq_ESCs_Mouse0.81312121
171TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81285397
172TP53_18474530_ChIP-ChIP_U2OS_Human0.79798601
173KLF4_19829295_ChIP-Seq_ESCs_Human0.79374069
174PIAS1_25552417_ChIP-Seq_VCAP_Human0.78927911
175SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78805451
176SOX2_22085726_ChIP-Seq_NPCs_Mouse0.78626828
177CTCF_20526341_ChIP-Seq_ESCs_Human0.78413727
178SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.78151033
179AR_20517297_ChIP-Seq_VCAP_Human0.77698295
180SA1_27219007_Chip-Seq_Bcells_Human0.77421190
181KLF5_25053715_ChIP-Seq_YYC3_Human0.77128931
182SOX2_21211035_ChIP-Seq_LN229_Human0.76513048
183HNFA_21074721_ChIP-Seq_CACO-2_Human0.75227171
184FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.74830879

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0001666_abnormal_nutrient_absorption9.24926836
2MP0005220_abnormal_exocrine_pancreas7.55892448
3MP0003868_abnormal_feces_composition6.29452571
4MP0005503_abnormal_tendon_morphology6.22829606
5MP0005275_abnormal_skin_tensile5.44219744
6* MP0005365_abnormal_bile_salt4.73085784
7* MP0005083_abnormal_biliary_tract4.35172985
8MP0001542_abnormal_bone_strength3.52291185
9MP0003959_abnormal_lean_body3.35223989
10MP0008004_abnormal_stomach_pH3.29845695
11MP0009250_abnormal_appendicular_skeleto3.13030407
12* MP0001664_abnormal_digestion2.74802180
13MP0003279_aneurysm2.69634665
14MP0001986_abnormal_taste_sensitivity2.66386494
15MP0002638_abnormal_pupillary_reflex2.62795190
16MP0005257_abnormal_intraocular_pressure2.55012211
17MP0002139_abnormal_hepatobiliary_system2.49240733
18MP0002277_abnormal_respiratory_mucosa2.39708973
19MP0005332_abnormal_amino_acid2.32190994
20* MP0002693_abnormal_pancreas_physiology2.31070193
21MP0002108_abnormal_muscle_morphology2.27157312
22MP0005508_abnormal_skeleton_morphology2.22487733
23MP0002138_abnormal_hepatobiliary_system2.15706442
24MP0004264_abnormal_extraembryonic_tissu2.13700868
25MP0002998_abnormal_bone_remodeling2.12728504
26MP0002115_abnormal_skeleton_extremities2.02120069
27* MP0005084_abnormal_gallbladder_morpholo1.90771827
28MP0003638_abnormal_response/metabolism_1.84389354
29* MP0005085_abnormal_gallbladder_physiolo1.75045768
30MP0010368_abnormal_lymphatic_system1.74818086
31MP0005171_absent_coat_pigmentation1.73186294
32MP0000534_abnormal_ureter_morphology1.72503378
33MP0004233_abnormal_muscle_weight1.71139414
34MP0003705_abnormal_hypodermis_morpholog1.71078240
35MP0003122_maternal_imprinting1.70202125
36MP0005390_skeleton_phenotype1.69926626
37MP0000470_abnormal_stomach_morphology1.69036542
38MP0009643_abnormal_urine_homeostasis1.68684502
39MP0001299_abnormal_eye_distance/1.68178731
40MP0000163_abnormal_cartilage_morphology1.66647773
41* MP0001944_abnormal_pancreas_morphology1.66589573
42MP0002109_abnormal_limb_morphology1.63516185
43MP0000428_abnormal_craniofacial_morphol1.59885391
44MP0000432_abnormal_head_morphology1.58399342
45MP0005360_urolithiasis1.52835280
46MP0008961_abnormal_basal_metabolism1.49537513
47MP0005451_abnormal_body_composition1.43525000
48MP0010352_gastrointestinal_tract_polyps1.43452540
49MP0005408_hypopigmentation1.42222520
50MP0010234_abnormal_vibrissa_follicle1.39923680
51MP0002113_abnormal_skeleton_development1.38451082
52MP0000767_abnormal_smooth_muscle1.38358928
53MP0002295_abnormal_pulmonary_circulatio1.37950134
54MP0003935_abnormal_craniofacial_develop1.37347841
55MP0005187_abnormal_penis_morphology1.36653517
56* MP0002118_abnormal_lipid_homeostasis1.33365404
57MP0000569_abnormal_digit_pigmentation1.32056020
58MP0003115_abnormal_respiratory_system1.27529578
59MP0002060_abnormal_skin_morphology1.27432156
60MP0004782_abnormal_surfactant_physiolog1.25522804
61MP0001533_abnormal_skeleton_physiology1.25460731
62MP0002116_abnormal_craniofacial_bone1.25047090
63MP0004043_abnormal_pH_regulation1.24773245
64MP0005197_abnormal_uvea_morphology1.24518404
65MP0003566_abnormal_cell_adhesion1.23312976
66MP0003283_abnormal_digestive_organ1.22089119
67MP0003252_abnormal_bile_duct1.20018344
68MP0005165_increased_susceptibility_to1.19966528
69MP0001873_stomach_inflammation1.18609873
70MP0005058_abnormal_lysosome_morphology1.17649824
71MP0002928_abnormal_bile_duct1.16889449
72MP0003941_abnormal_skin_development1.16369660
73MP0005623_abnormal_meninges_morphology1.14860009
74MP0003937_abnormal_limbs/digits/tail_de1.12444166
75MP0002751_abnormal_autonomic_nervous1.12256927
76MP0005023_abnormal_wound_healing1.12158016
77MP0000049_abnormal_middle_ear1.10363645
78* MP0005448_abnormal_energy_balance1.09139069
79MP0006054_spinal_hemorrhage1.07362252
80MP0000490_abnormal_crypts_of1.05655638
81MP0002078_abnormal_glucose_homeostasis1.03919139
82MP0002233_abnormal_nose_morphology1.03826353
83MP0001879_abnormal_lymphatic_vessel1.01880151
84MP0002168_other_aberrant_phenotype0.99203465
85MP0009384_cardiac_valve_regurgitation0.98624094
86MP0008438_abnormal_cutaneous_collagen0.96693777
87MP0002933_joint_inflammation0.96685157
88MP0001765_abnormal_ion_homeostasis0.94983443
89MP0000751_myopathy0.94833428
90MP0002876_abnormal_thyroid_physiology0.94508397
91MP0000566_synostosis0.93929511
92MP0004134_abnormal_chest_morphology0.93889794
93MP0002114_abnormal_axial_skeleton0.93756570
94MP0001663_abnormal_digestive_system0.91844835
95MP0005636_abnormal_mineral_homeostasis0.91225462
96MP0003953_abnormal_hormone_level0.90700474
97MP0003091_abnormal_cell_migration0.90553393
98MP0002932_abnormal_joint_morphology0.90176078
99MP0000613_abnormal_salivary_gland0.89688600
100MP0003755_abnormal_palate_morphology0.89633251
101MP0000759_abnormal_skeletal_muscle0.89162616
102MP0002938_white_spotting0.88206422
103MP0003186_abnormal_redox_activity0.87594900
104MP0000733_abnormal_muscle_development0.87426968
105MP0001958_emphysema0.85098563
106MP0008789_abnormal_olfactory_epithelium0.83982990
107MP0001756_abnormal_urination0.83176396
108MP0005377_hearing/vestibular/ear_phenot0.83001843
109MP0003878_abnormal_ear_physiology0.83001843
110MP0001177_atelectasis0.80325009
111MP0001243_abnormal_dermal_layer0.79750545
112MP0005381_digestive/alimentary_phenotyp0.75586194
113MP0000427_abnormal_hair_cycle0.74857541
114MP0002098_abnormal_vibrissa_morphology0.74546297
115MP0000762_abnormal_tongue_morphology0.73585025
116MP0003385_abnormal_body_wall0.72910506
117MP0004019_abnormal_vitamin_homeostasis0.71479208
118MP0005369_muscle_phenotype0.71163312
119MP0003123_paternal_imprinting0.71007106
120MP0002128_abnormal_blood_circulation0.70642395
121MP0005452_abnormal_adipose_tissue0.70015842
122MP0005076_abnormal_cell_differentiation0.66682498
123MP0001731_abnormal_postnatal_growth0.66456471
124MP0002133_abnormal_respiratory_system0.66017934
125MP0005388_respiratory_system_phenotype0.66017934
126MP0000003_abnormal_adipose_tissue0.65785214
127MP0010329_abnormal_lipoprotein_level0.65304047
128MP0005395_other_phenotype0.64250909
129MP0003567_abnormal_fetal_cardiomyocyte0.63210564
130MP0003936_abnormal_reproductive_system0.63147870
131MP0002089_abnormal_postnatal_growth/wei0.62787922
132MP0006036_abnormal_mitochondrial_physio0.62576056
133MP0004858_abnormal_nervous_system0.62034261
134MP0002796_impaired_skin_barrier0.61866049
135MP0002136_abnormal_kidney_physiology0.60933941
136MP0005193_abnormal_anterior_eye0.59121814
137MP0005319_abnormal_enzyme/_coenzyme0.58428775
138MP0005499_abnormal_olfactory_system0.58097746
139MP0005394_taste/olfaction_phenotype0.58097746
140MP0001175_abnormal_lung_morphology0.57645949
141MP0002697_abnormal_eye_size0.57472382
142MP0001764_abnormal_homeostasis0.57220388
143MP0004272_abnormal_basement_membrane0.55790202
144MP0003795_abnormal_bone_structure0.55076144
145MP0009765_abnormal_xenobiotic_induced0.54533516
146MP0002111_abnormal_tail_morphology0.53203625
147MP0000598_abnormal_liver_morphology0.53034693
148MP0003448_altered_tumor_morphology0.52445027
149MP0000462_abnormal_digestive_system0.52408359
150MP0000371_diluted_coat_color0.52310994
151MP0005595_abnormal_vascular_smooth0.51776799
152MP0002896_abnormal_bone_mineralization0.49373748
153MP0003942_abnormal_urinary_system0.49164643
154MP0002249_abnormal_larynx_morphology0.47915456
155MP0010030_abnormal_orbit_morphology0.47531610
156MP0005647_abnormal_sex_gland0.46496457
157MP0005334_abnormal_fat_pad0.46045170
158MP0009642_abnormal_blood_homeostasis0.45871526
159MP0000749_muscle_degeneration0.45102044
160MP0001270_distended_abdomen0.45053496
161MP0001845_abnormal_inflammatory_respons0.44628260
162MP0001614_abnormal_blood_vessel0.44576782
163MP0009780_abnormal_chondrocyte_physiolo0.44572119
164MP0010386_abnormal_urinary_bladder0.42777769
165MP0009703_decreased_birth_body0.42628066
166MP0008875_abnormal_xenobiotic_pharmacok0.41894918
167MP0000367_abnormal_coat/_hair0.40853318
168MP0000377_abnormal_hair_follicle0.38479784
169MP0000538_abnormal_urinary_bladder0.38346129
170MP0000778_abnormal_nervous_system0.37076250
171MP0000537_abnormal_urethra_morphology0.34690944
172MP0003183_abnormal_peptide_metabolism0.34686232
173* MP0002069_abnormal_eating/drinking_beha0.34665059
174* MP0005535_abnormal_body_temperature0.34282733
175* MP0002135_abnormal_kidney_morphology0.34179376
176MP0003045_fibrosis0.33642795

Predicted human phenotypes

RankGene SetZ-score
1Papilledema (HP:0001085)8.01400452
2Gout (HP:0001997)7.76964285
3Steatorrhea (HP:0002570)7.24371065
4Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.87026479
5Overgrowth (HP:0001548)5.99492327
6Fat malabsorption (HP:0002630)5.84533459
7Hypophosphatemic rickets (HP:0004912)5.54115950
8Broad ribs (HP:0000885)5.25105820
9Protrusio acetabuli (HP:0003179)5.11688746
10Asymmetry of the thorax (HP:0001555)4.81430318
11Short chin (HP:0000331)4.68681757
12Aortic aneurysm (HP:0004942)4.58865859
13Exocrine pancreatic insufficiency (HP:0001738)4.48328373
14Tubulointerstitial fibrosis (HP:0005576)4.44182748
15Increased density of long bones (HP:0006392)4.39876411
16Vascular tortuosity (HP:0004948)4.27060006
17Decreased subcutaneous fat (HP:0001002)4.26091334
18Increased purine levels (HP:0004368)4.15400934
19Hyperuricemia (HP:0002149)4.15400934
20Metaphyseal dysplasia (HP:0100255)4.10240205
21Type I diabetes mellitus (HP:0100651)4.04244467
22Renal salt wasting (HP:0000127)3.99873591
23Spinal cord compression (HP:0002176)3.96120419
24Tubulointerstitial nephritis (HP:0001970)3.94620151
25Mild short stature (HP:0003502)3.89544028
26Abnormality of the vertebral endplates (HP:0005106)3.89170179
27Spondylolisthesis (HP:0003302)3.87805807
28Aortic dissection (HP:0002647)3.87351278
29Abnormal pancreas size (HP:0012094)3.81507146
30Abnormality of subcutaneous fat tissue (HP:0001001)3.81002993
31Broad metatarsal (HP:0001783)3.75162684
32Ketoacidosis (HP:0001993)3.74703922
33Ketosis (HP:0001946)3.74512405
34Abnormality of calcium-phosphate metabolism (HP:0100530)3.68133132
35Arterial tortuosity (HP:0005116)3.60717496
36Maternal diabetes (HP:0009800)3.59821228
37Facial diplegia (HP:0001349)3.58561429
38Pancreatitis (HP:0001733)3.57442408
39Premature rupture of membranes (HP:0001788)3.56635271
40Abnormality of renal excretion (HP:0011036)3.54583223
41Hyperactive renin-angiotensin system (HP:0000841)3.53011747
42Hyperglycinuria (HP:0003108)3.52601727
43Tubular atrophy (HP:0000092)3.46071555
44Coronal craniosynostosis (HP:0004440)3.39891691
45Absent eyelashes (HP:0000561)3.38540616
46Abnormality of the intrinsic pathway (HP:0010989)3.37242745
47Hyperglycinemia (HP:0002154)3.36825167
48Cervical subluxation (HP:0003308)3.35164820
49Hypoplasia of the pons (HP:0012110)3.34875160
50Hypoproteinemia (HP:0003075)3.30429550
51Shallow orbits (HP:0000586)3.27833943
52Craniofacial hyperostosis (HP:0004493)3.27554504
53Metaphyseal cupping (HP:0003021)3.26496172
54Abnormality of glycine metabolism (HP:0010895)3.14836041
55Abnormality of serine family amino acid metabolism (HP:0010894)3.14836041
56Abnormality of the pons (HP:0007361)3.14492886
57Flared iliac wings (HP:0002869)3.12301976
58Choanal stenosis (HP:0000452)3.08034041
59Abnormality of aromatic amino acid family metabolism (HP:0004338)3.05239553
60Hypomagnesemia (HP:0002917)3.04875588
61Tibial bowing (HP:0002982)3.03715746
62Carpal bone hypoplasia (HP:0001498)3.01220239
63Cortical dysplasia (HP:0002539)3.00779753
64Joint stiffness (HP:0001387)2.98475635
65Persistence of primary teeth (HP:0006335)2.90658882
66Abnormality of purine metabolism (HP:0004352)2.90473681
67Wormian bones (HP:0002645)2.90125777
68Proximal tubulopathy (HP:0000114)2.88620979
69Cranial hyperostosis (HP:0004437)2.86001365
70Femoral bowing (HP:0002980)2.80979473
71Abnormality of chloride homeostasis (HP:0011422)2.78481114
72Hypotension (HP:0002615)2.74598127
73Irregular vertebral endplates (HP:0003301)2.73311556
74Abnormality of endocrine pancreas physiology (HP:0012093)2.72499560
75Abnormality of the pancreatic islet cells (HP:0006476)2.72499560
76Ankle contracture (HP:0006466)2.72127445
77Abnormal tarsal ossification (HP:0008369)2.71746126
78Tubulointerstitial abnormality (HP:0001969)2.69750759
79Metabolic alkalosis (HP:0200114)2.65238353
80Hypokalemic alkalosis (HP:0001949)2.65174839
81Vacuolated lymphocytes (HP:0001922)2.64948635
82Premature skin wrinkling (HP:0100678)2.62480948
83Wide anterior fontanel (HP:0000260)2.62363925
84Abnormality of magnesium homeostasis (HP:0004921)2.61155782
85Abnormality of the acetabulum (HP:0003170)2.57673341
86Enlarged epiphyses (HP:0010580)2.56046301
87Soft skin (HP:0000977)2.53630195
88Type 1 muscle fiber predominance (HP:0003803)2.53412609
89Spinal cord lesions (HP:0100561)2.50713828
90Syringomyelia (HP:0003396)2.50713828
91Follicular hyperkeratosis (HP:0007502)2.50442440
92Bladder diverticulum (HP:0000015)2.49234301
93Hyperextensible skin (HP:0000974)2.44045292
94Genu varum (HP:0002970)2.42422608
95Abnormality of the renal cortex (HP:0011035)2.40638218
96Congenital sensorineural hearing impairment (HP:0008527)2.38493068
97Abnormality of sulfur amino acid metabolism (HP:0004339)2.37708792
98Abnormality of the phalanges of the hallux (HP:0010057)2.35295686
99Coxa vara (HP:0002812)2.34647752
100Vascular calcification (HP:0004934)2.33274444
101Rickets (HP:0002748)2.31109567
102Osteomalacia (HP:0002749)2.30429625
103Neonatal short-limb short stature (HP:0008921)2.30235259
104Hypoplasia of the odontoid process (HP:0003311)2.29963284
105Methylmalonic aciduria (HP:0012120)2.29075054
106Barrel-shaped chest (HP:0001552)2.27497586
107Round ear (HP:0100830)2.25470099
108Dilatation of the ascending aorta (HP:0005111)2.21687066
109Optic nerve hypoplasia (HP:0000609)2.21241262
110Long foot (HP:0001833)2.20267527
111Increased circulating renin level (HP:0000848)2.19963019
112Late onset (HP:0003584)2.18873787
113Delayed cranial suture closure (HP:0000270)2.18512867
114Lymphangioma (HP:0100764)2.16377293
115Sudden death (HP:0001699)2.14863442
116Osteoarthritis (HP:0002758)2.13614482
117Mitral valve prolapse (HP:0001634)2.11648416
118Pectus carinatum (HP:0000768)2.10285855
119Hyperphosphatemia (HP:0002905)2.10032421
120Cardiovascular calcification (HP:0011915)2.09908305
121Absent eyebrow (HP:0002223)2.07014862
122Breast hypoplasia (HP:0003187)2.06559903
123Genu recurvatum (HP:0002816)2.05040803
124Dysostosis multiplex (HP:0000943)2.03398167
125Abnormality of the phalanges of the 2nd finger (HP:0009541)2.02860671
126Small epiphyses (HP:0010585)2.02469327
127Broad long bones (HP:0005622)2.02083849
128Enlarged penis (HP:0000040)1.99773210
129Abnormality of dentin (HP:0010299)1.99723626
130Abnormality of renin-angiotensin system (HP:0000847)1.99713836
131Increased corneal curvature (HP:0100692)1.99198172
132Keratoconus (HP:0000563)1.99198172
133Polyuria (HP:0000103)1.99042869
134Limited hip movement (HP:0008800)1.98828074
135Abnormality of aspartate family amino acid metabolism (HP:0010899)1.97374865
136Short middle phalanx of finger (HP:0005819)1.97031223
137Ventricular fibrillation (HP:0001663)1.96612131
138Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.95911365
139Vertebral compression fractures (HP:0002953)1.95612970
140Abnormality of Sharpey fibers (HP:0100685)1.95491385
141Acute encephalopathy (HP:0006846)1.95240146
142Glomerulosclerosis (HP:0000096)1.94064757
143Hyperaldosteronism (HP:0000859)1.93515473
144Broad phalanx (HP:0006009)1.93114837
145Dehydration (HP:0001944)1.92809558
146Aortic regurgitation (HP:0001659)1.92749778
147Abnormal protein N-linked glycosylation (HP:0012347)1.92425775
148Abnormal protein glycosylation (HP:0012346)1.92425775
149Abnormal glycosylation (HP:0012345)1.92425775
150Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92425775
151Metatarsus adductus (HP:0001840)1.92141697
152Generalized aminoaciduria (HP:0002909)1.91630987
153Prenatal maternal abnormality (HP:0002686)1.90706127
154Abnormal urine output (HP:0012590)1.90182763
155Tachypnea (HP:0002789)1.87742168
156Hypoventilation (HP:0002791)1.87562384
157Abnormality of the common coagulation pathway (HP:0010990)1.87004103
158Chronic hepatic failure (HP:0100626)1.86478613
159Abnormality of the odontoid process (HP:0003310)1.85463368
160Abnormality of the middle phalanges of the hand (HP:0009833)1.85224379
161Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.85219564
162Elbow flexion contracture (HP:0002987)1.85088746
163Bowel diverticulosis (HP:0005222)1.85017228
164Fatigue (HP:0012378)1.84875850
165Dicarboxylic aciduria (HP:0003215)1.84596754
166Abnormality of dicarboxylic acid metabolism (HP:0010995)1.84596754
167Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.84556659
168Aortic valve stenosis (HP:0001650)1.83697972
169Narrow palate (HP:0000189)1.83671987
170Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.82453931
171Ovoid vertebral bodies (HP:0003300)1.82346528
172Aneurysm (HP:0002617)1.82004400
173Glycosuria (HP:0003076)1.81388741
174Abnormality of urine glucose concentration (HP:0011016)1.81388741
175Joint laxity (HP:0001388)1.81057214
176Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.79969127
177Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79899241
178Abnormality of nucleobase metabolism (HP:0010932)1.79816910
179Abnormal cartilage morphology (HP:0002763)1.79546163
180Opisthotonus (HP:0002179)1.79191258
181Hyperammonemia (HP:0001987)1.77612631
182Absent frontal sinuses (HP:0002688)1.77119929
183Knee flexion contracture (HP:0006380)1.76453219
184Conjugated hyperbilirubinemia (HP:0002908)1.75415380
185Hypoplastic nipples (HP:0002557)1.75409284
186Abnormality of skull ossification (HP:0002703)1.75327071
187Hypoplasia of the uterus (HP:0000013)1.75192876
188Decreased skull ossification (HP:0004331)1.74945253
189Metabolic acidosis (HP:0001942)1.74308170
190Alkalosis (HP:0001948)1.73333162
191Mitral regurgitation (HP:0001653)1.72666940
192Termporal pattern (HP:0011008)1.72281130
193Insidious onset (HP:0003587)1.72281130
194Turricephaly (HP:0000262)1.71901815
195Osteolytic defects of the hand bones (HP:0009699)1.71742197

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK9.22843835
2MAP2K24.33987307
3ERN14.13300927
4WNK43.84005427
5EIF2AK33.82429450
6PKN23.36354808
7TRIB33.23332586
8TLK12.89264576
9ZAK2.38239276
10FRK2.35094146
11STK392.19675828
12ZAP702.16378407
13MAP3K101.93078249
14LATS11.85857711
15INSRR1.80932522
16MAP2K11.79381477
17IRAK31.59871247
18AKT31.53737048
19MAPKAPK31.48780799
20ICK1.46377941
21MYLK1.40981441
22OXSR11.39753699
23MELK1.35174241
24PNCK1.33655989
25PAK21.32765392
26CDC71.28744428
27WNK31.28291667
28DAPK21.25664413
29CASK1.24718518
30ABL21.21164135
31MAPK71.20993485
32FGFR41.15344475
33PTK61.11592357
34NME11.10295503
35CAMK1G1.07871907
36CHUK1.07686806
37TAOK31.07250178
38PDGFRB1.05985505
39MAP3K21.03568170
40PRKCE1.03275879
41NLK1.02315971
42RPS6KB21.01477286
43NME21.00519640
44DYRK1A0.98922495
45LRRK20.98697156
46SIK10.96929946
47STK38L0.96628753
48STK30.95159626
49TGFBR20.95147349
50WNK10.92868456
51RET0.92242513
52KIT0.91808702
53TIE10.90721219
54MUSK0.89683752
55PDK20.85038353
56CDK120.83573850
57SIK30.81627074
58PIK3CG0.81325610
59EPHB20.80418508
60IRAK20.78477710
61ADRBK10.77761212
62PKN10.77040687
63EEF2K0.76962159
64CAMKK10.74870877
65MAPK150.73590941
66PINK10.72445690
67MAP2K60.72328458
68RIPK10.71425212
69CDK80.69767721
70SGK20.69753767
71RPS6KA50.69718819
72FLT30.67528408
73FER0.66404841
74VRK10.65913516
75PIK3CA0.64305625
76RPS6KA20.64210694
77TGFBR10.63252567
78BRD40.60772030
79BRSK20.59184838
80PRKCZ0.58450505
81PRKD20.56869985
82GRK70.55466794
83TSSK60.53941992
84CAMK2G0.53557008
85SGK2230.53435041
86SGK4940.53435041
87JAK10.53393025
88MST1R0.51543351
89SCYL20.51308978
90CDK40.50731582
91GRK10.49970487
92GRK50.49913947
93TESK10.49878744
94CHEK20.49387110
95CDK60.49189690
96PRKCI0.47339434
97CDC42BPA0.47003924
98ERBB40.46490254
99CDK30.46401730
100TRPM70.45961411
101IRAK10.45919929
102PRKCG0.45619285
103PTK2B0.45515528
104MTOR0.44432043
105MARK20.43935194
106PDPK10.42210241
107BMPR1B0.42172418
108DYRK30.41968258
109ROCK10.41137518
110DAPK30.39673415
111MAPK120.38469259
112PRKACB0.38260438
113KSR20.37758603
114IRAK40.36688369
115PRKCD0.36442451
116NTRK10.35467691
117PIM20.35280587
118EPHA30.34453198
119ADRBK20.34247732
120SGK30.33961721
121CDK70.33802790
122STK40.33187920
123RPS6KB10.31536772
124CAMK40.31304006
125MAPK30.29676694
126MAPKAPK50.29487840
127PTK20.29408866
128LATS20.28904024
129NEK60.28836729
130CAMK1D0.27827476
131STK380.27654322
132MAP3K70.27623055
133ILK0.26796178
134MAPK110.25831187
135HIPK20.25770912
136MAPK140.25753980
137PDK40.25492165
138PDK30.25492165
139AKT20.25337787
140NEK90.24995267
141PDK10.23276473
142PRKCH0.23075924
143MAP2K40.21628177
144EPHB10.21514581
145LMTK20.21205619
146DYRK1B0.21063631
147ABL10.20017987
148PAK40.19738414
149IGF1R0.19697788
150MATK0.18918183
151GSK3A0.18272340
152MET0.18192504
153DDR20.17912276
154RPS6KA10.16929087
155ERBB20.16547359
156PDGFRA0.16294613
157MAP3K10.15496045
158PRKACA0.15094629
159AKT10.14810993

Predicted pathways (KEGG)

RankGene SetZ-score
1* Pancreatic secretion_Homo sapiens_hsa049727.59218705
2Protein digestion and absorption_Homo sapiens_hsa049745.74937896
3Fat digestion and absorption_Homo sapiens_hsa049755.54789763
4ECM-receptor interaction_Homo sapiens_hsa045124.96403744
5Glycerolipid metabolism_Homo sapiens_hsa005613.09621779
6Cyanoamino acid metabolism_Homo sapiens_hsa004603.07840895
7Maturity onset diabetes of the young_Homo sapiens_hsa049503.07372507
8Focal adhesion_Homo sapiens_hsa045102.93556709
9Protein export_Homo sapiens_hsa030602.92667241
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.60909328
11Folate biosynthesis_Homo sapiens_hsa007902.42682974
12TGF-beta signaling pathway_Homo sapiens_hsa043502.39152724
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.26093885
14Vitamin digestion and absorption_Homo sapiens_hsa049772.20050917
15Propanoate metabolism_Homo sapiens_hsa006402.17381543
16Melanoma_Homo sapiens_hsa052181.99590710
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.96991331
18Adherens junction_Homo sapiens_hsa045201.95559355
19Hedgehog signaling pathway_Homo sapiens_hsa043401.85975426
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.83485318
21PI3K-Akt signaling pathway_Homo sapiens_hsa041511.83418679
22Thyroid cancer_Homo sapiens_hsa052161.82188520
23MicroRNAs in cancer_Homo sapiens_hsa052061.79219070
24Alcoholism_Homo sapiens_hsa050341.76130075
25Wnt signaling pathway_Homo sapiens_hsa043101.71040138
26Steroid biosynthesis_Homo sapiens_hsa001001.70285939
27Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.68512415
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.67307672
29Proteoglycans in cancer_Homo sapiens_hsa052051.63758767
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.62199553
31Systemic lupus erythematosus_Homo sapiens_hsa053221.61720905
32Glioma_Homo sapiens_hsa052141.59305979
33Dilated cardiomyopathy_Homo sapiens_hsa054141.57736451
34Chronic myeloid leukemia_Homo sapiens_hsa052201.51366769
35Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.51220371
36Malaria_Homo sapiens_hsa051441.46806408
37Hippo signaling pathway_Homo sapiens_hsa043901.46671994
38Arginine and proline metabolism_Homo sapiens_hsa003301.37218210
39Renin-angiotensin system_Homo sapiens_hsa046141.36012519
40Basal cell carcinoma_Homo sapiens_hsa052171.33794430
41Cholinergic synapse_Homo sapiens_hsa047251.31429456
42Prolactin signaling pathway_Homo sapiens_hsa049171.30245108
43Colorectal cancer_Homo sapiens_hsa052101.29997125
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.23943196
45Regulation of actin cytoskeleton_Homo sapiens_hsa048101.19671079
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17861366
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.17026996
48Small cell lung cancer_Homo sapiens_hsa052221.13082309
49Starch and sucrose metabolism_Homo sapiens_hsa005001.10403253
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10380207
51Pathways in cancer_Homo sapiens_hsa052001.09464520
52beta-Alanine metabolism_Homo sapiens_hsa004101.08796431
53Carbohydrate digestion and absorption_Homo sapiens_hsa049731.07935923
54Gap junction_Homo sapiens_hsa045401.05003557
55Other glycan degradation_Homo sapiens_hsa005111.03702636
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.01222128
57Pancreatic cancer_Homo sapiens_hsa052120.97137458
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96649314
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.95925408
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.94735045
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93694927
62Melanogenesis_Homo sapiens_hsa049160.93522922
63Non-small cell lung cancer_Homo sapiens_hsa052230.92378162
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.91574539
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89548127
66Axon guidance_Homo sapiens_hsa043600.86860142
67Pyruvate metabolism_Homo sapiens_hsa006200.84924249
68Linoleic acid metabolism_Homo sapiens_hsa005910.84842172
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.84617586
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83337356
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82728777
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82404062
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81987369
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81283091
75Estrogen signaling pathway_Homo sapiens_hsa049150.81178470
76Fatty acid degradation_Homo sapiens_hsa000710.81124521
77Circadian rhythm_Homo sapiens_hsa047100.80566308
78Tryptophan metabolism_Homo sapiens_hsa003800.78926626
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.78356337
80N-Glycan biosynthesis_Homo sapiens_hsa005100.77528414
81Notch signaling pathway_Homo sapiens_hsa043300.75384175
82Rap1 signaling pathway_Homo sapiens_hsa040150.74816760
83Vibrio cholerae infection_Homo sapiens_hsa051100.71396058
84Sulfur metabolism_Homo sapiens_hsa009200.70745325
85Complement and coagulation cascades_Homo sapiens_hsa046100.69810013
86mTOR signaling pathway_Homo sapiens_hsa041500.69296104
87Ras signaling pathway_Homo sapiens_hsa040140.68068048
88Amoebiasis_Homo sapiens_hsa051460.68015794
89Butanoate metabolism_Homo sapiens_hsa006500.67505319
90Biosynthesis of amino acids_Homo sapiens_hsa012300.66486381
91p53 signaling pathway_Homo sapiens_hsa041150.65622081
92Viral carcinogenesis_Homo sapiens_hsa052030.62953117
93Glutathione metabolism_Homo sapiens_hsa004800.60151569
94Influenza A_Homo sapiens_hsa051640.58381464
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57420627
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56381494
97Choline metabolism in cancer_Homo sapiens_hsa052310.56350414
98Selenocompound metabolism_Homo sapiens_hsa004500.56188085
99ErbB signaling pathway_Homo sapiens_hsa040120.55897072
100* Insulin secretion_Homo sapiens_hsa049110.55476835
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55124461
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54086356
103MAPK signaling pathway_Homo sapiens_hsa040100.51925473
104Peroxisome_Homo sapiens_hsa041460.51668361
105FoxO signaling pathway_Homo sapiens_hsa040680.51426396
106Tight junction_Homo sapiens_hsa045300.50864644
107Cocaine addiction_Homo sapiens_hsa050300.50350793
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.49828646
109Cell cycle_Homo sapiens_hsa041100.49795776
110Renal cell carcinoma_Homo sapiens_hsa052110.49294251
111Dorso-ventral axis formation_Homo sapiens_hsa043200.49120932
112Arachidonic acid metabolism_Homo sapiens_hsa005900.48749653
113Collecting duct acid secretion_Homo sapiens_hsa049660.48473993
114* Calcium signaling pathway_Homo sapiens_hsa040200.48187474
115Parkinsons disease_Homo sapiens_hsa050120.47925484
116Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47201692
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.46473051
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45987508
119Fructose and mannose metabolism_Homo sapiens_hsa000510.45340282
120Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42725409
121Oxidative phosphorylation_Homo sapiens_hsa001900.42495809
122Histidine metabolism_Homo sapiens_hsa003400.42301123
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42161106
124Mineral absorption_Homo sapiens_hsa049780.42146357
125Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41927051
126cAMP signaling pathway_Homo sapiens_hsa040240.41756157
127One carbon pool by folate_Homo sapiens_hsa006700.41745987
128Ovarian steroidogenesis_Homo sapiens_hsa049130.39689795
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39488390
130HTLV-I infection_Homo sapiens_hsa051660.39229228
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39125231
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39120753
133Metabolic pathways_Homo sapiens_hsa011000.37162627
134Fanconi anemia pathway_Homo sapiens_hsa034600.37137764
135Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36933261
136Carbon metabolism_Homo sapiens_hsa012000.36864915
137Hepatitis B_Homo sapiens_hsa051610.36731075
138Platelet activation_Homo sapiens_hsa046110.35174865
139Endometrial cancer_Homo sapiens_hsa052130.34963670
140Non-homologous end-joining_Homo sapiens_hsa034500.34781159
141Alzheimers disease_Homo sapiens_hsa050100.34632080
142Lysosome_Homo sapiens_hsa041420.34445417
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32241020
144Ether lipid metabolism_Homo sapiens_hsa005650.32168561
145Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31034345
146Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30795104
147Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28737191
148Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28414976
149* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.27659815
150Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26945614
151Primary bile acid biosynthesis_Homo sapiens_hsa001200.26651210
152Fatty acid metabolism_Homo sapiens_hsa012120.25720069
153Bile secretion_Homo sapiens_hsa049760.25477983
154Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.23372200
155SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23013913
156Arginine biosynthesis_Homo sapiens_hsa002200.20948737
157Gastric acid secretion_Homo sapiens_hsa049710.20157763
158Lysine degradation_Homo sapiens_hsa003100.18972922
159Thyroid hormone synthesis_Homo sapiens_hsa049180.18400989
160Regulation of autophagy_Homo sapiens_hsa041400.17940984
161Legionellosis_Homo sapiens_hsa051340.17650050
162Sulfur relay system_Homo sapiens_hsa041220.17403846
163Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.14734077
164Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.10626517
165Taste transduction_Homo sapiens_hsa047420.06651317
166Prostate cancer_Homo sapiens_hsa052150.05209452
167VEGF signaling pathway_Homo sapiens_hsa043700.04911494
168Glycosaminoglycan degradation_Homo sapiens_hsa005310.04106829
169Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.03314553
170Chemical carcinogenesis_Homo sapiens_hsa052040.03125706
171Viral myocarditis_Homo sapiens_hsa054160.00340368
172Bladder cancer_Homo sapiens_hsa05219-0.0354995
173Toxoplasmosis_Homo sapiens_hsa05145-0.0206202
174Huntingtons disease_Homo sapiens_hsa05016-0.0193943
175Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980-0.0174567
176Hepatitis C_Homo sapiens_hsa05160-0.0135687

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