CCL11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gas transport (GO:0015669)8.78778233
2hemidesmosome assembly (GO:0031581)7.51337538
3positive regulation of respiratory burst (GO:0060267)7.10653614
4angiotensin maturation (GO:0002003)6.97469051
5complement activation, classical pathway (GO:0006958)6.60893730
6response to interferon-alpha (GO:0035455)6.55192042
7antibacterial humoral response (GO:0019731)6.18820669
8positive regulation of pseudopodium assembly (GO:0031274)6.12532868
9regulation of cellular extravasation (GO:0002691)6.04620900
10antimicrobial humoral response (GO:0019730)6.02584408
11glomerular filtration (GO:0003094)6.01749344
12negative regulation of fatty acid biosynthetic process (GO:0045717)5.75993088
13regulation of guanylate cyclase activity (GO:0031282)5.65987342
14T cell lineage commitment (GO:0002360)5.62664624
15regulation of pseudopodium assembly (GO:0031272)5.52484626
16regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.40751643
17complement activation (GO:0006956)5.28419279
18intestinal absorption (GO:0050892)4.96082638
19bone resorption (GO:0045453)4.88721494
20NADH metabolic process (GO:0006734)4.70356211
21type I interferon signaling pathway (GO:0060337)4.68808427
22cellular response to type I interferon (GO:0071357)4.68808427
23cellular response to interferon-alpha (GO:0035457)4.67993220
24response to type I interferon (GO:0034340)4.62453889
25regulation of respiratory burst (GO:0060263)4.60129903
26positive regulation of guanylate cyclase activity (GO:0031284)4.44336115
27regulation of cardioblast proliferation (GO:0003264)4.24794705
28regulation of secondary heart field cardioblast proliferation (GO:0003266)4.24794705
29antigen processing and presentation of endogenous antigen (GO:0019883)4.17136335
30sulfur amino acid catabolic process (GO:0000098)4.16986262
31cellular response to virus (GO:0098586)4.10103743
32negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.94740875
33negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.90143757
34protein activation cascade (GO:0072376)3.89820387
35kidney mesenchyme development (GO:0072074)3.89093087
36metanephric mesenchyme development (GO:0072075)3.86850754
37regulation of systemic arterial blood pressure by hormone (GO:0001990)3.79756628
38regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.79756628
39endocrine process (GO:0050886)3.79756628
40positive regulation of glycoprotein biosynthetic process (GO:0010560)3.71656462
41regulation of bile acid biosynthetic process (GO:0070857)3.68519628
42regulation of cGMP biosynthetic process (GO:0030826)3.68433002
43negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.67822172
44bundle of His cell to Purkinje myocyte communication (GO:0086069)3.67460885
45lipoprotein transport (GO:0042953)3.66961613
46fructose metabolic process (GO:0006000)3.60105730
47GDP-mannose metabolic process (GO:0019673)3.58102076
48regulation of vitamin metabolic process (GO:0030656)3.57965503
49maintenance of gastrointestinal epithelium (GO:0030277)3.56651249
50homeostasis of number of cells within a tissue (GO:0048873)3.49860747
51positive regulation of glycoprotein metabolic process (GO:1903020)3.47564202
52regulation of systemic arterial blood pressure (GO:0003073)3.47561603
53humoral immune response (GO:0006959)3.46103675
54negative regulation of fatty acid metabolic process (GO:0045922)3.44682714
55hormone catabolic process (GO:0042447)3.33082830
56peptide catabolic process (GO:0043171)3.32710475
57fat-soluble vitamin biosynthetic process (GO:0042362)3.31250687
58protein heterotrimerization (GO:0070208)3.27002099
59interferon-gamma-mediated signaling pathway (GO:0060333)3.24969470
60adhesion of symbiont to host cell (GO:0044650)3.24747927
61virion attachment to host cell (GO:0019062)3.24747927
62positive regulation of Cdc42 GTPase activity (GO:0043089)3.24381310
63myoblast migration (GO:0051451)3.24318848
64arginine metabolic process (GO:0006525)3.21341120
65regulation of cGMP metabolic process (GO:0030823)3.20449504
66nephron tubule formation (GO:0072079)3.19740446
67urea cycle (GO:0000050)3.18906048
68regulation of interleukin-12 biosynthetic process (GO:0045075)3.18142973
69receptor guanylyl cyclase signaling pathway (GO:0007168)3.17719869
70antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.16552756
71antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.16552756
72epoxygenase P450 pathway (GO:0019373)3.14124503
73renal system process involved in regulation of blood volume (GO:0001977)3.12734442
74negative regulation of leukocyte chemotaxis (GO:0002689)3.10418230
75regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.10405782
76regulation of extracellular matrix disassembly (GO:0010715)3.09163320
77peptide hormone processing (GO:0016486)3.08120873
78cell-substrate junction assembly (GO:0007044)3.07526927
79vitamin A metabolic process (GO:0006776)3.06794419
80nucleoside diphosphate biosynthetic process (GO:0009133)3.05574417
81regulation of response to interferon-gamma (GO:0060330)3.05098347
82oligosaccharide biosynthetic process (GO:0009312)3.04961591
83response to interferon-beta (GO:0035456)2.99080240
84negative regulation of leukocyte migration (GO:0002686)2.98657622
85transcytosis (GO:0045056)2.98596843
86urea metabolic process (GO:0019627)2.98479976
87diacylglycerol metabolic process (GO:0046339)2.98298481
88digestion (GO:0007586)2.98015959
89positive regulation of natural killer cell differentiation (GO:0032825)2.97475610
90negative regulation of signal transduction in absence of ligand (GO:1901099)2.95882603
91negative regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001240)2.95882603
92sequestering of extracellular ligand from receptor (GO:0035581)2.95256774
93ethanol oxidation (GO:0006069)2.95243081
94positive regulation of macrophage cytokine production (GO:0060907)2.95035954
95positive regulation of interferon-alpha production (GO:0032727)2.94712368
96midgut development (GO:0007494)2.93070015
97cGMP-mediated signaling (GO:0019934)2.91703861
98nitrogen cycle metabolic process (GO:0071941)2.90651980
99calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.89290760
100cyclooxygenase pathway (GO:0019371)2.87941080
101positive regulation of hair cycle (GO:0042635)2.87923765
102positive regulation of hair follicle development (GO:0051798)2.87923765
103lipid particle organization (GO:0034389)2.86188441
104peripheral nervous system axon ensheathment (GO:0032292)2.84040842
105myelination in peripheral nervous system (GO:0022011)2.84040842
106phosphatidylserine acyl-chain remodeling (GO:0036150)2.83362311
107positive regulation of cGMP biosynthetic process (GO:0030828)2.83115344
108regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.83072543
109adhesion of symbiont to host (GO:0044406)2.80162895
110glycolipid catabolic process (GO:0019377)2.79864964
111anatomical structure regression (GO:0060033)2.79247897
112phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.79077248
113regulation of dendritic cell antigen processing and presentation (GO:0002604)2.77252251
114outer ear morphogenesis (GO:0042473)2.75977300
115cell proliferation involved in metanephros development (GO:0072203)2.75573958
116glycosphingolipid catabolic process (GO:0046479)2.75142429
117regulation of interferon-alpha production (GO:0032647)2.73967607
118retina vasculature morphogenesis in camera-type eye (GO:0061299)2.73796411
119low-density lipoprotein particle remodeling (GO:0034374)2.73692736
120regulation of fatty acid biosynthetic process (GO:0042304)2.72300028
121positive regulation of antigen processing and presentation (GO:0002579)2.71652300
122lipoprotein metabolic process (GO:0042157)2.70178190
123arginine catabolic process (GO:0006527)2.70128386
124cell differentiation involved in metanephros development (GO:0072202)2.69364171
125epithelial structure maintenance (GO:0010669)2.69354719
126carnitine shuttle (GO:0006853)2.69243924
127regulation of Cdc42 GTPase activity (GO:0043088)2.69028680
128phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.68279589
129bile acid and bile salt transport (GO:0015721)2.64751526
130positive regulation of cGMP metabolic process (GO:0030825)2.63063592
131regulation of type I interferon-mediated signaling pathway (GO:0060338)2.62599492
132fatty acid transmembrane transport (GO:1902001)2.62451018
133peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.62246935
134disruption of cells of other organism (GO:0044364)2.59551097
135killing of cells of other organism (GO:0031640)2.59551097
136antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.59453119
137regulation of RIG-I signaling pathway (GO:0039535)2.59225880
138positive regulation of megakaryocyte differentiation (GO:0045654)2.58641728
139drug metabolic process (GO:0017144)2.58521856
140cellular response to interferon-gamma (GO:0071346)2.58168151
141negative regulation of epidermal cell differentiation (GO:0045605)2.57544698
142regulation of amyloid precursor protein catabolic process (GO:1902991)2.56048531
143negative regulation of interleukin-10 production (GO:0032693)2.55655604
144glomerulus development (GO:0032835)2.55622509
145regulation of antigen processing and presentation (GO:0002577)2.54605056
146very-low-density lipoprotein particle assembly (GO:0034379)2.53867197
147O-glycan processing (GO:0016266)2.53801667
148phosphatidylinositol acyl-chain remodeling (GO:0036149)2.53499149
149response to nitric oxide (GO:0071731)2.53131662
150digestive system process (GO:0022600)2.53082169
151regulation of hair follicle development (GO:0051797)2.51521899
152respiratory tube development (GO:0030323)2.50068065
153response to interferon-gamma (GO:0034341)2.48959987
154mesenchymal cell differentiation involved in renal system development (GO:2001012)2.48819023
155mesenchymal cell differentiation involved in kidney development (GO:0072161)2.48819023
156fibril organization (GO:0097435)2.48485508
157negative regulation of kidney development (GO:0090185)2.48211026
158JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.46971593
159cellular response to cadmium ion (GO:0071276)2.46740051
160glucuronate metabolic process (GO:0019585)2.46511534
161aorta morphogenesis (GO:0035909)2.45449503
162cellular response to nicotine (GO:0071316)2.44991912
163cellular response to prostaglandin stimulus (GO:0071379)2.44507877
164cell proliferation involved in kidney development (GO:0072111)2.44144981
165keratan sulfate catabolic process (GO:0042340)2.43422433
166cortical actin cytoskeleton organization (GO:0030866)2.42642189
167cellular response to vitamin (GO:0071295)2.42488360
168antigen processing and presentation via MHC class Ib (GO:0002475)2.41908338
169regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.40569419
170interleukin-6-mediated signaling pathway (GO:0070102)2.40252698
171negative regulation of protein autophosphorylation (GO:0031953)2.39245143
172extracellular matrix assembly (GO:0085029)2.38515259
173positive regulation of Rho protein signal transduction (GO:0035025)2.38449317
174negative regulation of lipid storage (GO:0010888)2.38093554
175endodermal cell differentiation (GO:0035987)2.35942862
176positive regulation of autophagy (GO:0010508)2.34857489
177regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.33462317
178negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.32814010
179cellular response to interleukin-6 (GO:0071354)2.32645973
180fatty acid homeostasis (GO:0055089)2.27856337
181apoptotic cell clearance (GO:0043277)2.26234393
182ganglion development (GO:0061548)2.23362393
183response to prostaglandin (GO:0034694)2.23055860
184axon extension involved in axon guidance (GO:0048846)2.22959250
185neuron projection extension involved in neuron projection guidance (GO:1902284)2.22959250
186negative regulation of keratinocyte proliferation (GO:0010839)2.22941384
187renal filtration (GO:0097205)2.22834527
188thyroid hormone generation (GO:0006590)2.20468884
189filopodium assembly (GO:0046847)2.20314228
190oxygen transport (GO:0015671)14.3660035

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.96578187
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.32694934
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.71195956
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.47687524
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.24863047
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.23613247
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.04799599
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.40664489
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.37767508
10SOX2_27498859_Chip-Seq_STOMACH_Mouse2.25780092
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.25554404
12CLOCK_20551151_ChIP-Seq_293T_Human2.22511261
13GATA4_25053715_ChIP-Seq_YYC3_Human2.15762051
14CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.14058306
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.02739527
16ESR1_15608294_ChIP-ChIP_MCF-7_Human1.95844865
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85598252
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.83532204
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.82141234
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.81433426
21EP300_21415370_ChIP-Seq_HL-1_Mouse1.80145574
22GATA6_25053715_ChIP-Seq_YYC3_Human1.66905587
23ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.66365699
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.62964319
25PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.60995045
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.59409244
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58235983
28PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.57907410
29* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54981794
30HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.53565820
31GATA2_21666600_ChIP-Seq_HMVEC_Human1.53530089
32IRF8_21731497_ChIP-ChIP_J774_Mouse1.52708248
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.52354114
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.52151030
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.51428976
36AHR_22903824_ChIP-Seq_MCF-7_Human1.50552560
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.48482851
38CJUN_26792858_Chip-Seq_BT549_Human1.46126393
39RNF2_18974828_ChIP-Seq_MESCs_Mouse1.44436674
40EZH2_18974828_ChIP-Seq_MESCs_Mouse1.44436674
41SOX2_20726797_ChIP-Seq_SW620_Human1.43615968
42* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.42446850
43NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.42295813
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41378282
45SOX9_24532713_ChIP-Seq_HFSC_Mouse1.38006813
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.33868224
47SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.27459543
48BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.27178549
49TBX20_22080862_ChIP-Seq_HEART_Mouse1.25566816
50TBX20_22328084_ChIP-Seq_HEART_Mouse1.25566816
51FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.24794102
52LXR_22158963_ChIP-Seq_LIVER_Mouse1.24259921
53PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24159906
54SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23930701
55TP53_18474530_ChIP-ChIP_U2OS_Human1.23907902
56FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22306053
57VDR_24787735_ChIP-Seq_THP-1_Human1.22095942
58TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21295317
59KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20234276
60NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.19825775
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19816258
62STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19472372
63EGR1_19032775_ChIP-ChIP_M12_Human1.18185723
64RAD21_21589869_ChIP-Seq_MESCs_Mouse1.17169610
65ELK3_25401928_ChIP-Seq_HUVEC_Human1.15969215
66ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15647791
67ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.15523354
68TP53_20018659_ChIP-ChIP_R1E_Mouse1.15181250
69SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.14948295
70SA1_27219007_Chip-Seq_Bcells_Human1.13122323
71ESR1_20079471_ChIP-ChIP_T-47D_Human1.12840909
72JARID2_20075857_ChIP-Seq_MESCs_Mouse1.12621927
73* BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.11579639
74ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.09503329
75SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.08912410
76SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.08912410
77RNF2_27304074_Chip-Seq_ESCs_Mouse1.08406751
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08144111
79PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08032008
80EZH2_27304074_Chip-Seq_ESCs_Mouse1.07336224
81SMC1_22415368_ChIP-Seq_MEFs_Mouse1.07039445
82SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06440575
83NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05352336
84RXR_22158963_ChIP-Seq_LIVER_Mouse1.05155562
85CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.04191801
86TET1_21451524_ChIP-Seq_MESCs_Mouse1.03851218
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.02891953
88SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02825198
89NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02776336
90NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02776336
91CTCF_27219007_Chip-Seq_Bcells_Human1.02210882
92CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01138313
93STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.00988652
94EZH2_27294783_Chip-Seq_ESCs_Mouse1.00930635
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00838544
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00838544
97KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.00723538
98KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.00723538
99KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.00723538
100SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00634395
101UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00071750
102TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99675639
103RACK7_27058665_Chip-Seq_MCF-7_Human0.99629944
104TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99238170
105EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99112342
106IRF8_27001747_Chip-Seq_BMDM_Mouse0.98025464
107STAT1_20625510_ChIP-Seq_HELA_Human0.97548994
108FOXO3_23340844_ChIP-Seq_DLD1_Human0.97238539
109KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97138017
110BRD4_25478319_ChIP-Seq_HGPS_Human0.96952323
111CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96422020
112TP53_16413492_ChIP-PET_HCT116_Human0.95512725
113KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95251379
114PPARA_22158963_ChIP-Seq_LIVER_Mouse0.94829663
115LXR_22292898_ChIP-Seq_THP-1_Human0.94669194
116VDR_24763502_ChIP-Seq_THP-1_Human0.94645290
117TCF4_18268006_ChIP-ChIP_LS174T_Human0.93577738
118* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93251723
119RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.92208753
120* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91730490
121SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.91587463
122P63_26484246_Chip-Seq_KERATINOCYTES_Human0.89972417
123DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89888634
124SMC3_22415368_ChIP-Seq_MEFs_Mouse0.89588469
125GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88939660
126TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.88578620
127VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.88313719
128CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88181049
129SUZ12_27294783_Chip-Seq_ESCs_Mouse0.88044634
130BCL6_27268052_Chip-Seq_Bcells_Human0.87818017
131KLF5_25053715_ChIP-Seq_YYC3_Human0.86515613
132RXR_22108803_ChIP-Seq_LS180_Human0.86313697
133THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86211333
134GATA3_24758297_ChIP-Seq_MCF-7_Human0.86113074
135CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.85542573
136STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.85236063
137CDX2_20551321_ChIP-Seq_CACO-2_Human0.85231199
138FOXA1_25552417_ChIP-Seq_VCAP_Human0.83920995
139DROSHA_22980978_ChIP-Seq_HELA_Human0.83462842
140JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.83203076
141BCOR_27268052_Chip-Seq_Bcells_Human0.82396921
142SA1_27219007_Chip-Seq_ERYTHROID_Human0.82221839
143SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.78883423
144CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.78762456
145GATA2_19941826_ChIP-Seq_K562_Human0.78350007
146AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.77544144
147FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.76581222
148GATA1_19941826_ChIP-Seq_K562_Human0.76285916
149STAT4_19710469_ChIP-ChIP_TH1__Mouse0.75997745
150RUNX1_27514584_Chip-Seq_MCF-7_Human0.75897306
151IKZF1_21737484_ChIP-ChIP_HCT116_Human0.75835717
152NFIB_24661679_ChIP-Seq_LUNG_Mouse0.75690912
153PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.74510768

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat6.99231632
2MP0005360_urolithiasis5.14658554
3MP0005275_abnormal_skin_tensile4.18014292
4MP0004510_myositis4.07187375
5MP0001346_abnormal_lacrimal_gland4.06557546
6MP0008438_abnormal_cutaneous_collagen3.78410340
7MP0003705_abnormal_hypodermis_morpholog3.57014142
8MP0002139_abnormal_hepatobiliary_system3.47064517
9MP0001666_abnormal_nutrient_absorption3.30368599
10MP0003724_increased_susceptibility_to2.86120337
11MP0009379_abnormal_foot_pigmentation2.84982822
12MP0005085_abnormal_gallbladder_physiolo2.74704165
13MP0000579_abnormal_nail_morphology2.71302579
14MP0009840_abnormal_foam_cell2.65811584
15MP0004272_abnormal_basement_membrane2.65310152
16MP0002876_abnormal_thyroid_physiology2.50735717
17MP0005503_abnormal_tendon_morphology2.46003348
18MP0002138_abnormal_hepatobiliary_system2.45191234
19MP0000751_myopathy2.30669779
20MP0004019_abnormal_vitamin_homeostasis2.25110354
21MP0002060_abnormal_skin_morphology2.23333524
22MP0010352_gastrointestinal_tract_polyps2.19123601
23MP0000467_abnormal_esophagus_morphology2.17498959
24MP0003183_abnormal_peptide_metabolism2.17074478
25MP0003566_abnormal_cell_adhesion2.11020903
26MP0005166_decreased_susceptibility_to2.02916146
27MP0003866_abnormal_defecation1.99079670
28MP0002166_altered_tumor_susceptibility1.93324280
29MP0005365_abnormal_bile_salt1.91077977
30MP0001664_abnormal_digestion1.90902665
31MP0000685_abnormal_immune_system1.88671606
32MP0001853_heart_inflammation1.76927356
33MP0001873_stomach_inflammation1.76808464
34MP0010030_abnormal_orbit_morphology1.74718869
35MP0003300_gastrointestinal_ulcer1.73342860
36MP0005451_abnormal_body_composition1.69640273
37MP0000490_abnormal_crypts_of1.66189509
38MP0003453_abnormal_keratinocyte_physiol1.63371050
39MP0006054_spinal_hemorrhage1.62901838
40MP0000477_abnormal_intestine_morphology1.62498372
41MP0005409_darkened_coat_color1.61217933
42MP0001663_abnormal_digestive_system1.60543154
43MP0000383_abnormal_hair_follicle1.59984240
44MP0010234_abnormal_vibrissa_follicle1.59715954
45MP0000733_abnormal_muscle_development1.59052563
46MP0003436_decreased_susceptibility_to1.55784285
47MP0000762_abnormal_tongue_morphology1.55602466
48MP0002277_abnormal_respiratory_mucosa1.50465584
49MP0010678_abnormal_skin_adnexa1.50293476
50MP0005023_abnormal_wound_healing1.49117361
51MP0004147_increased_porphyrin_level1.43611449
52MP0002006_tumorigenesis1.42672607
53MP0005381_digestive/alimentary_phenotyp1.40282623
54MP0004782_abnormal_surfactant_physiolog1.39268224
55MP0002098_abnormal_vibrissa_morphology1.37400515
56MP0008004_abnormal_stomach_pH1.34447789
57MP0004130_abnormal_muscle_cell1.33820999
58MP0008789_abnormal_olfactory_epithelium1.32930465
59MP0006082_CNS_inflammation1.31608358
60MP0005025_abnormal_response_to1.30963397
61MP0009785_altered_susceptibility_to1.30584401
62MP0000462_abnormal_digestive_system1.29460321
63MP0005257_abnormal_intraocular_pressure1.29053041
64MP0002796_impaired_skin_barrier1.27242123
65MP0000427_abnormal_hair_cycle1.26814866
66MP0000465_gastrointestinal_hemorrhage1.26597890
67MP0000604_amyloidosis1.23565425
68MP0009643_abnormal_urine_homeostasis1.20801657
69MP0003045_fibrosis1.20728968
70* MP0001845_abnormal_inflammatory_respons1.18787622
71MP0002108_abnormal_muscle_morphology1.18307960
72MP0005332_abnormal_amino_acid1.16134160
73* MP0005387_immune_system_phenotype1.15858869
74* MP0001790_abnormal_immune_system1.15858869
75MP0000681_abnormal_thyroid_gland1.11484700
76MP0003329_amyloid_beta_deposits1.10845405
77MP0008961_abnormal_basal_metabolism1.10033610
78MP0005165_increased_susceptibility_to1.08852680
79MP0010329_abnormal_lipoprotein_level1.06807221
80MP0002295_abnormal_pulmonary_circulatio1.06680963
81MP0001756_abnormal_urination1.06323043
82MP0004264_abnormal_extraembryonic_tissu1.06006457
83MP0000749_muscle_degeneration1.04433673
84MP0002136_abnormal_kidney_physiology1.03713583
85MP0002148_abnormal_hypersensitivity_rea1.03675301
86MP0003448_altered_tumor_morphology1.02863944
87MP0003941_abnormal_skin_development1.01558973
88MP0003191_abnormal_cellular_cholesterol1.00073438
89MP0003091_abnormal_cell_migration0.97435608
90MP0003868_abnormal_feces_composition0.97284278
91MP0001835_abnormal_antigen_presentation0.97281111
92MP0002998_abnormal_bone_remodeling0.97096929
93MP0001216_abnormal_epidermal_layer0.97088542
94MP0003252_abnormal_bile_duct0.95950478
95MP0009764_decreased_sensitivity_to0.95594245
96MP0001299_abnormal_eye_distance/0.94670731
97MP0009250_abnormal_appendicular_skeleto0.93572282
98MP0001348_abnormal_lacrimal_gland0.92898412
99MP0000613_abnormal_salivary_gland0.92682459
100MP0001849_ear_inflammation0.92569554
101MP0001958_emphysema0.92009075
102MP0005058_abnormal_lysosome_morphology0.91747373
103MP0010368_abnormal_lymphatic_system0.91727189
104MP0006138_congestive_heart_failure0.91509684
105MP0000013_abnormal_adipose_tissue0.91411107
106MP0004185_abnormal_adipocyte_glucose0.91009495
107MP0001765_abnormal_ion_homeostasis0.90018704
108MP0000566_synostosis0.89133882
109MP0003279_aneurysm0.87790130
110MP0000538_abnormal_urinary_bladder0.87785989
111MP0002933_joint_inflammation0.87138778
112MP0001542_abnormal_bone_strength0.86794452
113MP0000377_abnormal_hair_follicle0.85805377
114MP0000534_abnormal_ureter_morphology0.85334490
115MP0002233_abnormal_nose_morphology0.85062628
116MP0003828_pulmonary_edema0.84906906
117MP0009384_cardiac_valve_regurgitation0.84816215
118MP0005508_abnormal_skeleton_morphology0.84782193
119MP0003385_abnormal_body_wall0.84447882
120MP0001800_abnormal_humoral_immune0.83881766
121MP0000249_abnormal_blood_vessel0.83855065
122MP0003075_altered_response_to0.81586983
123MP0000343_altered_response_to0.80502935
124MP0004858_abnormal_nervous_system0.80358435
125MP0002234_abnormal_pharynx_morphology0.79179180
126MP0004947_skin_inflammation0.78933488
127MP0005000_abnormal_immune_tolerance0.78692136
128MP0000750_abnormal_muscle_regeneration0.78566754
129MP0004087_abnormal_muscle_fiber0.78489050
130MP0010771_integument_phenotype0.77095484
131MP0001533_abnormal_skeleton_physiology0.76687160
132MP0001764_abnormal_homeostasis0.75447237
133MP0005623_abnormal_meninges_morphology0.75335168
134MP0001881_abnormal_mammary_gland0.74941402
135MP0001243_abnormal_dermal_layer0.74815924
136MP0005666_abnormal_adipose_tissue0.74653461
137MP0008469_abnormal_protein_level0.73790626
138MP0010155_abnormal_intestine_physiology0.73682615
139MP0005369_muscle_phenotype0.72628402
140MP0009278_abnormal_bone_marrow0.72034165
141MP0000230_abnormal_systemic_arterial0.70780006
142MP0002009_preneoplasia0.70585825
143MP0005584_abnormal_enzyme/coenzyme_acti0.70413660
144MP0002106_abnormal_muscle_physiology0.69662299
145MP0000759_abnormal_skeletal_muscle0.69289438
146MP0003806_abnormal_nucleotide_metabolis0.69205206
147MP0003795_abnormal_bone_structure0.69120390
148MP0002269_muscular_atrophy0.68741900
149MP0001501_abnormal_sleep_pattern0.68203151
150MP0003303_peritoneal_inflammation0.67830742
151MP0002896_abnormal_bone_mineralization0.67611756
152MP0002419_abnormal_innate_immunity0.67544697
153MP0005670_abnormal_white_adipose0.67480192
154MP0000627_abnormal_mammary_gland0.67012987
155MP0002168_other_aberrant_phenotype0.65315036
156MP0009115_abnormal_fat_cell0.64679307
157MP0005330_cardiomyopathy0.63650501
158MP0000678_abnormal_parathyroid_gland0.62685877
159MP0005390_skeleton_phenotype0.61839934
160MP0005375_adipose_tissue_phenotype0.60957542
161MP0001270_distended_abdomen0.60722681
162MP0002332_abnormal_exercise_endurance0.59054546
163MP0001851_eye_inflammation0.58656169
164MP0002972_abnormal_cardiac_muscle0.58451573
165MP0000516_abnormal_urinary_system0.57355747

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)7.26217682
2Malnutrition (HP:0004395)6.36087523
3Milia (HP:0001056)4.90186288
4Atrophic scars (HP:0001075)4.86688041
5Vertebral compression fractures (HP:0002953)4.67278435
6Natal tooth (HP:0000695)4.62373530
7Abnormality of complement system (HP:0005339)4.44622064
8Type 1 muscle fiber predominance (HP:0003803)4.32999877
9Onycholysis (HP:0001806)4.24264082
10Follicular hyperkeratosis (HP:0007502)4.21153692
11Abnormality of the fingertips (HP:0001211)4.20543610
12Autoimmune hemolytic anemia (HP:0001890)4.03917003
13Ankle contracture (HP:0006466)3.92821960
14Glomerulonephritis (HP:0000099)3.75773882
15Lip pit (HP:0100267)3.75657681
16Right ventricular cardiomyopathy (HP:0011663)3.72523882
17Plantar hyperkeratosis (HP:0007556)3.64533114
18Esophageal varix (HP:0002040)3.60439587
19Biconcave vertebral bodies (HP:0004586)3.50537135
20Increased connective tissue (HP:0009025)3.38399919
21Ileus (HP:0002595)3.36787781
22Chronic diarrhea (HP:0002028)3.32782252
23Fragile nails (HP:0001808)3.32484939
24Aplasia cutis congenita (HP:0001057)3.29327703
25Fat malabsorption (HP:0002630)3.23172256
26Congenital sensorineural hearing impairment (HP:0008527)3.13495416
27Advanced eruption of teeth (HP:0006288)3.10009659
28Colitis (HP:0002583)3.09227896
29Protrusio acetabuli (HP:0003179)3.06307535
30Tetraparesis (HP:0002273)3.05073247
31Pili torti (HP:0003777)3.00683103
32Abnormal hair laboratory examination (HP:0003328)2.97984656
33Dry hair (HP:0011359)2.94222010
34Nasolacrimal duct obstruction (HP:0000579)2.93239370
35Broad metatarsal (HP:0001783)2.92168122
36Decreased circulating renin level (HP:0003351)2.91333759
37Exercise-induced myalgia (HP:0003738)2.90878080
38Increased variability in muscle fiber diameter (HP:0003557)2.86673591
39Beaking of vertebral bodies (HP:0004568)2.85320868
40Abnormality of the vitamin B12 metabolism (HP:0004341)2.84926847
41Wormian bones (HP:0002645)2.83850444
42Abnormality of monocarboxylic acid metabolism (HP:0010996)2.80925864
43Spontaneous abortion (HP:0005268)2.80020876
44Metabolic alkalosis (HP:0200114)2.78979949
45Abnormality of vitamin B metabolism (HP:0004340)2.76629491
46Alkalosis (HP:0001948)2.72337252
47Spinal rigidity (HP:0003306)2.71167440
48Growth hormone excess (HP:0000845)2.70276887
49Slender build (HP:0001533)2.63933371
50Shallow orbits (HP:0000586)2.60897806
51Widely patent fontanelles and sutures (HP:0004492)2.58232213
52Abnormality of the gastric mucosa (HP:0004295)2.57744229
53Thin bony cortex (HP:0002753)2.57585946
54Nail dystrophy (HP:0008404)2.57386506
55Adactyly (HP:0009776)2.56713817
56Hyperactive renin-angiotensin system (HP:0000841)2.56571793
57Mildly elevated creatine phosphokinase (HP:0008180)2.55927298
58Cervical subluxation (HP:0003308)2.54846969
59Abnormality of the nasal mucosa (HP:0000433)2.53557632
60Emphysema (HP:0002097)2.52680960
61Gastrointestinal stroma tumor (HP:0100723)2.52499165
62Fragile skin (HP:0001030)2.51543272
63Abnormality of skeletal muscle fiber size (HP:0012084)2.50276129
64Esophageal atresia (HP:0002032)2.50235700
65Epidermoid cyst (HP:0200040)2.50047043
66Nausea (HP:0002018)2.47059676
67Hypoplasia of dental enamel (HP:0006297)2.46679430
68Hypobetalipoproteinemia (HP:0003563)2.43564511
69Vascular tortuosity (HP:0004948)2.42017359
70Abnormality of the right ventricle (HP:0001707)2.39787024
71Skull defect (HP:0001362)2.38830031
72Aortic dissection (HP:0002647)2.38494199
73IgM deficiency (HP:0002850)2.37013111
74Round ear (HP:0100830)2.36030085
75Thick nail (HP:0001805)2.35996935
76Hemorrhage of the eye (HP:0011885)2.34089992
77Abnormality of proline metabolism (HP:0010907)2.34065862
78Hydroxyprolinuria (HP:0003080)2.34065862
79Selective tooth agenesis (HP:0001592)2.33366496
80Cerebral aneurysm (HP:0004944)2.31583037
81Osteolytic defects of the hand bones (HP:0009699)2.31186277
82Osteolytic defects of the phalanges of the hand (HP:0009771)2.31186277
83Proximal tubulopathy (HP:0000114)2.30915260
84Increased purine levels (HP:0004368)2.29423830
85Hyperuricemia (HP:0002149)2.29423830
86Steatorrhea (HP:0002570)2.28275284
87Conjugated hyperbilirubinemia (HP:0002908)2.27247994
88Premature rupture of membranes (HP:0001788)2.25972507
89Palmoplantar hyperkeratosis (HP:0000972)2.25591401
90Wide cranial sutures (HP:0010537)2.25153815
91Villous atrophy (HP:0011473)2.24038939
92Abnormality of small intestinal villus morphology (HP:0011472)2.24038939
93Abdominal distention (HP:0003270)2.23553513
94Severe short stature (HP:0003510)2.22003841
95Bone cyst (HP:0012062)2.21294551
96Abnormality of renin-angiotensin system (HP:0000847)2.20333028
97Palmar hyperkeratosis (HP:0010765)2.18936988
98Abnormality of vitamin metabolism (HP:0100508)2.18009489
99Hyperparathyroidism (HP:0000843)2.17804717
100Glycosuria (HP:0003076)2.17582252
101Abnormality of urine glucose concentration (HP:0011016)2.17582252
102Aortic aneurysm (HP:0004942)2.17162659
103Porencephaly (HP:0002132)2.16733219
104Abnormality of the lacrimal duct (HP:0011481)2.15150485
105Abnormality of the ischium (HP:0003174)2.15144367
106Abnormality of glutamine family amino acid metabolism (HP:0010902)2.14652466
107Xanthomatosis (HP:0000991)2.11884595
108Recurrent bronchitis (HP:0002837)2.11537034
109Rectal prolapse (HP:0002035)2.10231401
110Pigmentary retinal degeneration (HP:0001146)2.09258022
111Hyporeflexia of lower limbs (HP:0002600)2.05744807
112Acanthosis nigricans (HP:0000956)2.04452502
113Abnormality of macrophages (HP:0004311)2.03861288
114Thrombocytosis (HP:0001894)2.03450773
115Scapular winging (HP:0003691)2.02873737
116Neonatal short-limb short stature (HP:0008921)2.02696367
117Hyperphosphatemia (HP:0002905)2.01249825
118Nephrolithiasis (HP:0000787)1.98789268
119Muscle fiber splitting (HP:0003555)1.96918997
120Gingivitis (HP:0000230)1.96004134
121Abnormal delivery (HP:0001787)1.95353808
122Premature loss of primary teeth (HP:0006323)1.95050375
123Hypophosphatemia (HP:0002148)1.94200157
124Arterial tortuosity (HP:0005116)1.93856387
125Nephritis (HP:0000123)1.93453791
126Fatigable weakness (HP:0003473)1.92130880
127Abnormality of the neuromuscular junction (HP:0003398)1.92130880
128Hyperextensible skin (HP:0000974)1.92023045
129Absent hand (HP:0004050)1.91193933
130Confusion (HP:0001289)1.90948257
131Hematochezia (HP:0002573)1.90021993
132Inflammation of the large intestine (HP:0002037)1.89196969
133Cerebral palsy (HP:0100021)1.88027927
134Pancreatitis (HP:0001733)1.87845491
135Hypotension (HP:0002615)1.87367703
136Vasculitis (HP:0002633)1.85460913
137Periauricular skin pits (HP:0100277)1.85422576
138Preauricular pit (HP:0004467)1.85422576
139Abnormality of the nasolacrimal system (HP:0000614)1.84405604
140Ventricular tachycardia (HP:0004756)1.82951913
141Mixed hearing impairment (HP:0000410)1.82862674
142Aneurysm (HP:0002617)1.82371930
143Abnormality of the costochondral junction (HP:0000919)1.82081532
144Abnormality of purine metabolism (HP:0004352)1.81960311
145IgA deficiency (HP:0002720)1.79447907
146Bladder diverticulum (HP:0000015)1.78983850
147Peritonitis (HP:0002586)1.78813690
148Fibular hypoplasia (HP:0003038)1.78733592
149Acanthocytosis (HP:0001927)1.78467916
150Ulnar claw (HP:0001178)1.78424647
151Spontaneous hematomas (HP:0007420)1.76174459
152Dysostosis multiplex (HP:0000943)1.76123847
153Difficulty running (HP:0009046)1.75922618
154Protuberant abdomen (HP:0001538)1.75814273
155Segmental peripheral demyelination/remyelination (HP:0003481)1.75655900
156Eczematoid dermatitis (HP:0000976)1.75318855
157Alopecia of scalp (HP:0002293)1.74936849
158Complement deficiency (HP:0004431)1.74659766
159Enlarged epiphyses (HP:0010580)1.74088623
160Gastrointestinal dysmotility (HP:0002579)1.74055957
161Bone pain (HP:0002653)1.73409898
162Weak cry (HP:0001612)1.73344953
163Congenital, generalized hypertrichosis (HP:0004540)1.73000501
164Mitral valve prolapse (HP:0001634)1.72920641
165Patent foramen ovale (HP:0001655)1.72785602
166Spondylolisthesis (HP:0003302)1.72501775
167Ventricular fibrillation (HP:0001663)1.71991034
168Nasal polyposis (HP:0100582)1.70244955
169Stroke (HP:0001297)1.70147993
170Amyloidosis (HP:0011034)1.69967619
171Focal segmental glomerulosclerosis (HP:0000097)1.69951138
172Hyperammonemia (HP:0001987)1.69867887

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B3.95352726
2RIPK13.90229163
3IKBKE3.38765959
4NME13.17562197
5CLK13.00095056
6TTN2.62580498
7RPS6KA42.54491034
8GRK62.48399390
9FGFR42.47269216
10TBK12.24743408
11MAPK152.15415982
12PHKG12.07068583
13PHKG22.07068583
14RPS6KB22.06646600
15EPHA21.99682779
16ZAK1.97171756
17DDR21.95312984
18TSSK61.88773981
19TYK21.87777086
20EPHA31.86818740
21MAP3K101.83130081
22CAMK1D1.82445396
23GRK11.77769317
24PIK3CG1.71799815
25PIK3CA1.71031334
26EPHB11.67439120
27MAPKAPK31.66031237
28TGFBR21.65560097
29LATS11.63989469
30NUAK11.52828245
31CHUK1.50716308
32JAK11.50381744
33ERN11.49357690
34ADRBK21.48562945
35MAP3K71.42183428
36CAMK41.42052178
37TRIB31.41503394
38STK391.36196997
39PDGFRA1.35164796
40MAP3K121.35132422
41PTK61.34837143
42TESK11.33205495
43TIE11.32267174
44MAP4K11.30951992
45PTK21.28143037
46MYLK1.26759607
47ABL21.23301488
48PRKAA21.22455214
49MAP3K141.22453341
50MAP2K21.12969813
51FGFR11.12596562
52PRPF4B1.10875393
53FGFR31.10186888
54MST41.07469154
55FER1.07213640
56DAPK21.06660324
57KIT1.05059701
58OXSR11.02824719
59CAMK1G1.02769133
60ZAP701.02446765
61JAK21.01761948
62PAK21.00250983
63FGFR20.97805898
64IKBKB0.94666059
65JAK30.94350326
66LMTK20.94149148
67TGFBR10.93692006
68PRKG20.92786859
69EPHB20.90909810
70ERBB30.84451879
71SIK10.84346223
72TESK20.83890355
73STK240.81546407
74NTRK10.81025978
75PDPK10.80175461
76CAMK2G0.80127231
77MATK0.79334553
78MAP3K110.77430882
79PAK40.76063729
80LATS20.72747966
81HIPK20.72545835
82ADRBK10.70288098
83RIPK40.69519174
84RPS6KA60.66573044
85MAPK70.65740562
86BMPR1B0.64705021
87BMX0.64516175
88MAP3K30.64103514
89MAP3K10.63051540
90MAPKAPK50.62426442
91MST1R0.60856245
92DMPK0.58485973
93MET0.58376182
94DYRK1B0.57891501
95PTK2B0.55422249
96PRKAA10.54502028
97IRAK10.54076037
98BTK0.53631321
99LRRK20.52597456
100CDK60.52323682
101TAOK10.51645379
102SMG10.49840045
103KDR0.48233421
104EGFR0.48185321
105ERBB20.48127137
106SRC0.47581663
107MAP2K10.46978125
108BCR0.46226061
109PRKCD0.44956718
110BLK0.44719534
111GSK3A0.44310783
112MAPKAPK20.42356671
113ERBB40.42040648
114OBSCN0.40878164
115CAMK2D0.39670244
116KSR20.39622391
117PIM20.39439575
118DAPK30.39238483
119PRKACG0.39122114
120PRKCA0.38998735
121NLK0.38530512
122CDC42BPA0.38380995
123MTOR0.37937320
124LYN0.37527687
125PRKD10.37346304
126MAP3K20.36961038
127PAK30.36951777
128PDK10.36873384
129MAPK110.36345455
130RPS6KA50.36173486
131RET0.35616248
132STK100.35117101
133ROCK10.34640800
134RPS6KL10.34488983
135RPS6KC10.34488983
136PDK40.33812613
137PDK30.33812613
138PRKCZ0.33403616
139INSR0.33369888
140VRK10.33267484
141IGF1R0.33093342
142PRKD20.32817671
143CDK190.32664178
144CSK0.32035708
145GRK50.31624614
146PDK20.31562617
147PDGFRB0.31497575
148BMPR20.31053766
149TXK0.30869169
150ILK0.29903013
151TNIK0.29885772
152FYN0.27900919
153RPS6KA20.26984851

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009205.14956166
2Renin-angiotensin system_Homo sapiens_hsa046143.03876547
3ECM-receptor interaction_Homo sapiens_hsa045122.88821654
4Vitamin digestion and absorption_Homo sapiens_hsa049772.88474460
5Mineral absorption_Homo sapiens_hsa049782.49003919
6Fructose and mannose metabolism_Homo sapiens_hsa000512.16096483
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.10988781
8* Asthma_Homo sapiens_hsa053101.89388465
9Allograft rejection_Homo sapiens_hsa053301.88755868
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.87786397
11Amoebiasis_Homo sapiens_hsa051461.80308793
12Influenza A_Homo sapiens_hsa051641.75871049
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.74496654
14Autoimmune thyroid disease_Homo sapiens_hsa053201.74217360
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.73917175
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.72434601
17Insulin resistance_Homo sapiens_hsa049311.71535911
18Hematopoietic cell lineage_Homo sapiens_hsa046401.71055686
19Leishmaniasis_Homo sapiens_hsa051401.70976125
20Graft-versus-host disease_Homo sapiens_hsa053321.70781582
21Nitrogen metabolism_Homo sapiens_hsa009101.67840545
22Toxoplasmosis_Homo sapiens_hsa051451.66491187
23Histidine metabolism_Homo sapiens_hsa003401.65612295
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.60996805
25Focal adhesion_Homo sapiens_hsa045101.60995556
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.53708138
27Adherens junction_Homo sapiens_hsa045201.44365058
28Type I diabetes mellitus_Homo sapiens_hsa049401.42938629
29Protein digestion and absorption_Homo sapiens_hsa049741.41712872
30Chemical carcinogenesis_Homo sapiens_hsa052041.39862965
31Hepatitis C_Homo sapiens_hsa051601.37623093
32Small cell lung cancer_Homo sapiens_hsa052221.34880288
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.30895978
34Galactose metabolism_Homo sapiens_hsa000521.30275960
35Osteoclast differentiation_Homo sapiens_hsa043801.29410430
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.28294284
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.27950944
38Retinol metabolism_Homo sapiens_hsa008301.25018089
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.24766491
40Starch and sucrose metabolism_Homo sapiens_hsa005001.24183529
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.23587694
42Arginine biosynthesis_Homo sapiens_hsa002201.22935003
43Ether lipid metabolism_Homo sapiens_hsa005651.22716728
44Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.21843209
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.20772573
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.19776281
47Dilated cardiomyopathy_Homo sapiens_hsa054141.18787070
48* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.18727580
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17969003
50PPAR signaling pathway_Homo sapiens_hsa033201.17898508
51Adipocytokine signaling pathway_Homo sapiens_hsa049201.16482870
52Pancreatic secretion_Homo sapiens_hsa049721.15395688
53Measles_Homo sapiens_hsa051621.12896358
54Arginine and proline metabolism_Homo sapiens_hsa003301.12847758
55Herpes simplex infection_Homo sapiens_hsa051681.11612805
56Glutathione metabolism_Homo sapiens_hsa004801.11036993
57Carbohydrate digestion and absorption_Homo sapiens_hsa049731.09652903
58Pertussis_Homo sapiens_hsa051331.08620136
59Antigen processing and presentation_Homo sapiens_hsa046121.08474382
60NF-kappa B signaling pathway_Homo sapiens_hsa040641.08151984
61TGF-beta signaling pathway_Homo sapiens_hsa043501.02270411
62Primary bile acid biosynthesis_Homo sapiens_hsa001201.02163135
63Other glycan degradation_Homo sapiens_hsa005111.01473343
64Caffeine metabolism_Homo sapiens_hsa002320.99413829
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.98599509
66PI3K-Akt signaling pathway_Homo sapiens_hsa041510.96733421
67Legionellosis_Homo sapiens_hsa051340.90537091
68Fatty acid metabolism_Homo sapiens_hsa012120.89819769
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89425401
70Malaria_Homo sapiens_hsa051440.87482207
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.86986750
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86529618
73Prolactin signaling pathway_Homo sapiens_hsa049170.85945308
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85736187
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85384380
76TNF signaling pathway_Homo sapiens_hsa046680.85030920
77Proteoglycans in cancer_Homo sapiens_hsa052050.83434705
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.82526207
79Linoleic acid metabolism_Homo sapiens_hsa005910.82198977
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.79293972
81Tryptophan metabolism_Homo sapiens_hsa003800.76483739
82Fatty acid biosynthesis_Homo sapiens_hsa000610.75434208
83Prion diseases_Homo sapiens_hsa050200.75328213
84Fatty acid degradation_Homo sapiens_hsa000710.73393642
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73226690
86Rheumatoid arthritis_Homo sapiens_hsa053230.71574955
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71551839
88Hepatitis B_Homo sapiens_hsa051610.71411804
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71343155
90Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71223237
91African trypanosomiasis_Homo sapiens_hsa051430.71076819
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70853938
93Glucagon signaling pathway_Homo sapiens_hsa049220.68695034
94Tight junction_Homo sapiens_hsa045300.68654299
95Staphylococcus aureus infection_Homo sapiens_hsa051500.67370255
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66493733
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64011581
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63672067
99Cocaine addiction_Homo sapiens_hsa050300.63157660
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63080039
101Pancreatic cancer_Homo sapiens_hsa052120.63016394
102Complement and coagulation cascades_Homo sapiens_hsa046100.61625872
103Renin secretion_Homo sapiens_hsa049240.61172638
104Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60755851
105Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60571511
106Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60152381
107Salmonella infection_Homo sapiens_hsa051320.58033949
108Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56630188
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55051029
110Glycerolipid metabolism_Homo sapiens_hsa005610.53986164
111Bile secretion_Homo sapiens_hsa049760.53101012
112Pathways in cancer_Homo sapiens_hsa052000.51975958
113Thyroid hormone synthesis_Homo sapiens_hsa049180.51973616
114Insulin signaling pathway_Homo sapiens_hsa049100.51544187
115Circadian rhythm_Homo sapiens_hsa047100.51296258
116HIF-1 signaling pathway_Homo sapiens_hsa040660.50537751
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.50247917
118Gastric acid secretion_Homo sapiens_hsa049710.49488590
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49240802
120p53 signaling pathway_Homo sapiens_hsa041150.48651196
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47563303
122Sphingolipid metabolism_Homo sapiens_hsa006000.47083002
123MicroRNAs in cancer_Homo sapiens_hsa052060.46756655
124Estrogen signaling pathway_Homo sapiens_hsa049150.45541218
125Fat digestion and absorption_Homo sapiens_hsa049750.44147765
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44104150
127Glycosaminoglycan degradation_Homo sapiens_hsa005310.42974491
128Gap junction_Homo sapiens_hsa045400.42849235
129Propanoate metabolism_Homo sapiens_hsa006400.42712441
130Hippo signaling pathway_Homo sapiens_hsa043900.42258821
131Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42081775
132Pyruvate metabolism_Homo sapiens_hsa006200.41649561
133Viral myocarditis_Homo sapiens_hsa054160.41327649
134Sulfur relay system_Homo sapiens_hsa041220.40455039
135Bladder cancer_Homo sapiens_hsa052190.40197046
136Prostate cancer_Homo sapiens_hsa052150.39667207
137Vascular smooth muscle contraction_Homo sapiens_hsa042700.39057565
138Arachidonic acid metabolism_Homo sapiens_hsa005900.38969732
139Tuberculosis_Homo sapiens_hsa051520.38895713
140Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38258680
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37735126
142Dorso-ventral axis formation_Homo sapiens_hsa043200.37600068
143Phagosome_Homo sapiens_hsa041450.37562791
144Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37424462
145* Chemokine signaling pathway_Homo sapiens_hsa040620.36726248
146Lysosome_Homo sapiens_hsa041420.36586760
147Phenylalanine metabolism_Homo sapiens_hsa003600.31153414
148Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.29695598
149Pentose phosphate pathway_Homo sapiens_hsa000300.26035553
150Peroxisome_Homo sapiens_hsa041460.24993323
151Tyrosine metabolism_Homo sapiens_hsa003500.21566737
152Vibrio cholerae infection_Homo sapiens_hsa051100.20936556

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