ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	epoxygenase P450 pathway (GO:0019373)	7.13261911
2	ethanol oxidation (GO:0006069)	5.79642993
3	exogenous drug catabolic process (GO:0042738)	5.70316152
4	drug catabolic process (GO:0042737)	5.64495292
5	angiotensin maturation (GO:0002003)	5.59157539
6	urea metabolic process (GO:0019627)	5.16944121
7	complement activation, alternative pathway (GO:0006957)	5.15367514
8	drug metabolic process (GO:0017144)	5.12954889
9	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	5.05821123
10	fat-soluble vitamin biosynthetic process (GO:0042362)	4.98137933
11	ethanol metabolic process (GO:0006067)	4.88517334
12	urea cycle (GO:0000050)	4.86014580
13	complement activation, classical pathway (GO:0006958)	4.83682694
14	cellular glucuronidation (GO:0052695)	4.79923488
15	nitrogen cycle metabolic process (GO:0071941)	4.76089842
16	regulation of protein activation cascade (GO:2000257)	4.75816106
17	glucuronate metabolic process (GO:0019585)	4.68130123
18	uronic acid metabolic process (GO:0006063)	4.68130123
19	omega-hydroxylase P450 pathway (GO:0097267)	4.67112331
20	regulation of complement activation (GO:0030449)	4.63728558
21	intestinal absorption (GO:0050892)	4.56537948
22	regulation of triglyceride catabolic process (GO:0010896)	4.54810127
23	complement activation (GO:0006956)	4.47219238
24	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	4.26829109
25	positive regulation of triglyceride lipase activity (GO:0061365)	4.24752346
26	positive regulation of lipoprotein lipase activity (GO:0051006)	4.24752346
27	phospholipid efflux (GO:0033700)	4.14742264
28	NADH metabolic process (GO:0006734)	4.14381357
29	bile acid and bile salt transport (GO:0015721)	4.14332721
30	protein activation cascade (GO:0072376)	4.09720370
31	regulation of fibrinolysis (GO:0051917)	4.07540368
32	fructose metabolic process (GO:0006000)	4.06589233
33	hormone catabolic process (GO:0042447)	4.01069106
34	protein-lipid complex remodeling (GO:0034368)	3.95825082
35	macromolecular complex remodeling (GO:0034367)	3.95825082
36	plasma lipoprotein particle remodeling (GO:0034369)	3.95825082
37	regulation of cholesterol esterification (GO:0010872)	3.93336108
38	very-low-density lipoprotein particle assembly (GO:0034379)	3.92670846
39	bile acid metabolic process (GO:0008206)	3.90398997
40	acute-phase response (GO:0006953)	3.87913993
41	negative regulation of fibrinolysis (GO:0051918)	3.85915028
42	negative regulation of sterol transport (GO:0032372)	3.76728139
43	negative regulation of cholesterol transport (GO:0032375)	3.76728139
44	glyoxylate metabolic process (GO:0046487)	3.75479590
45	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.72787240
46	L-phenylalanine metabolic process (GO:0006558)	3.72787240
47	flavonoid metabolic process (GO:0009812)	3.72367583
48	L-phenylalanine catabolic process (GO:0006559)	3.71500038
49	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.71500038
50	regulation of guanylate cyclase activity (GO:0031282)	3.71329853
51	regulation of bile acid biosynthetic process (GO:0070857)	3.70343598
52	arginine metabolic process (GO:0006525)	3.66102481
53	phenylpropanoid metabolic process (GO:0009698)	3.59412480
54	plasma lipoprotein particle assembly (GO:0034377)	3.59364544
55	diacylglycerol metabolic process (GO:0046339)	3.59303156
56	primary alcohol catabolic process (GO:0034310)	3.56615501
57	alkaloid metabolic process (GO:0009820)	3.56286453
58	fibrinolysis (GO:0042730)	3.53135444
59	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.50504569
60	regulation of cellular extravasation (GO:0002691)	3.48569280
61	high-density lipoprotein particle remodeling (GO:0034375)	3.48547289
62	lipoprotein transport (GO:0042953)	3.48445862
63	low-density lipoprotein particle remodeling (GO:0034374)	3.47997113
64	positive regulation of fatty acid biosynthetic process (GO:0045723)	3.45504225
65	positive regulation of lipid catabolic process (GO:0050996)	3.45503832
66	cholesterol efflux (GO:0033344)	3.41767501
67	lipoprotein metabolic process (GO:0042157)	3.40822858
68	plasma lipoprotein particle organization (GO:0071827)	3.37800879
69	renal system process involved in regulation of blood volume (GO:0001977)	3.36135419
70	negative regulation of hemostasis (GO:1900047)	3.34916561
71	negative regulation of blood coagulation (GO:0030195)	3.34916561
72	peptidyl-glutamic acid carboxylation (GO:0017187)	3.33645043
73	protein carboxylation (GO:0018214)	3.33645043
74	protein-lipid complex assembly (GO:0065005)	3.29386103
75	protein-lipid complex subunit organization (GO:0071825)	3.22755890
76	reverse cholesterol transport (GO:0043691)	3.19436983
77	regulation of humoral immune response (GO:0002920)	3.17524731
78	bile acid biosynthetic process (GO:0006699)	3.15454665
79	adhesion of symbiont to host cell (GO:0044650)	3.13487563
80	virion attachment to host cell (GO:0019062)	3.13487563
81	maintenance of gastrointestinal epithelium (GO:0030277)	3.12951080
82	negative regulation of coagulation (GO:0050819)	3.12692511
83	regulation of vitamin metabolic process (GO:0030656)	3.09757721
84	regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)	3.08420596
85	endocrine process (GO:0050886)	3.08420596
86	regulation of systemic arterial blood pressure by hormone (GO:0001990)	3.08420596
87	renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)	3.07755382
88	primary alcohol metabolic process (GO:0034308)	3.00494409
89	aromatic amino acid family catabolic process (GO:0009074)	2.98288516
90	positive regulation of pseudopodium assembly (GO:0031274)	2.96071487
91	acylglycerol homeostasis (GO:0055090)	2.94714423
92	triglyceride homeostasis (GO:0070328)	2.94714423
93	negative regulation of wound healing (GO:0061045)	2.94360502
94	positive regulation of respiratory burst (GO:0060267)	2.89897472
95	antimicrobial humoral response (GO:0019730)	2.89325569
96	glutamine family amino acid biosynthetic process (GO:0009084)	2.88634380
97	xenobiotic metabolic process (GO:0006805)	2.87696170
98	glycosphingolipid catabolic process (GO:0046479)	2.85516988
99	acute inflammatory response (GO:0002526)	2.85373153
100	blood coagulation, intrinsic pathway (GO:0007597)	2.85297370

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	6.26441352
2	RXR_22158963_ChIP-Seq_LIVER_Mouse	4.17147768
3	PPARA_22158963_ChIP-Seq_LIVER_Mouse	3.63262868
4	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	3.52099416
5	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.46362429
6	EGR1_23403033_ChIP-Seq_LIVER_Mouse	3.43231352
7	LXR_22158963_ChIP-Seq_LIVER_Mouse	3.38015610
8	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.32032055
9	CDX2_20551321_ChIP-Seq_CACO-2_Human	3.16418435
10	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	2.95781653
11	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.70052769
12	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	2.60205364
13	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.18424618
14	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.16904656
15	SOX2_27498859_Chip-Seq_STOMACH_Mouse	2.12224041
16	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.00248005
17	GATA4_25053715_ChIP-Seq_YYC3_Human	1.93819968
18	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.93471167
19	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.92064111
20	SOX2_20726797_ChIP-Seq_SW620_Human	1.83148365
21	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.81961930
22	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.79626551
23	LXR_22292898_ChIP-Seq_THP-1_Human	1.79464669
24	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.76759721
25	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.63854410
26	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.63159950
27	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.63128599
28	GATA6_25053715_ChIP-Seq_YYC3_Human	1.59587269
29	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.58674953
30	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.52373782
31	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.52249567
32	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.47823236
33	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.47073151
34	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.40192939
35	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.37221699
36	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.36559551
37	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.36066796
38	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.34594647
39	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.33400842
40	CLOCK_20551151_ChIP-Seq_293T_Human	1.27453588
41	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.26123169
42	RACK7_27058665_Chip-Seq_MCF-7_Human	1.23548975
43	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.22136801
44	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.22115457
45	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.19802639
46	GATA1_22025678_ChIP-Seq_K562_Human	1.16278856
47	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.15674204
48	SA1_27219007_Chip-Seq_Bcells_Human	1.14706326
49	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.14076064
50	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.13365886
51	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.13298093
52	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.11486269
53	BCOR_27268052_Chip-Seq_Bcells_Human	1.10645544
54	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.10205527
55	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.10170306
56	BCL6_27268052_Chip-Seq_Bcells_Human	1.08787702
57	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.06538214
58	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.05288730
59	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.04049413
60	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.02095899
61	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.00388104
62	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.00317087
63	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.99389574
64	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.98939192
65	CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.98665303
66	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.98600599
67	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.95822738
68	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.93804419
69	STAT1_20625510_ChIP-Seq_HELA_Human	0.92295518
70	CTCF_27219007_Chip-Seq_Bcells_Human	0.92069834
71	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.91611123
72	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.90942659
73	GATA1_19941826_ChIP-Seq_K562_Human	0.90073830
74	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.89771701
75	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	0.89631429
76	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.88482789
77	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.87669434
78	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.86350538
79	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.85210705
80	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.83956276
81	VDR_24763502_ChIP-Seq_THP-1_Human	0.83815316
82	KLF5_25053715_ChIP-Seq_YYC3_Human	0.83289620
83	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.83110902
84	CTCF_20526341_ChIP-Seq_ESCs_Human	0.82847153
85	CEBPB_22108803_ChIP-Seq_LS180_Human	0.81631243
86	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.81535805
87	SMC4_20622854_ChIP-Seq_HELA_Human	0.81181904
88	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	0.79539812
89	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.79462597
90	GATA2_19941826_ChIP-Seq_K562_Human	0.78986986
91	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.78016087
92	GATA1_22383799_ChIP-Seq_G1ME_Mouse	0.74379838
93	E2F1_20622854_ChIP-Seq_HELA_Human	0.74186178
94	DROSHA_22980978_ChIP-Seq_HELA_Human	0.74070327
95	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.73053040
96	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.72994307
97	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.72481285
98	TP63_22573176_ChIP-Seq_HFKS_Human	0.72349236
99	P300_27268052_Chip-Seq_Bcells_Human	0.72203529
100	ZNF263_19887448_ChIP-Seq_K562_Human	0.71928916

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	7.33648367
2	MP0005360_urolithiasis	6.75891088
3	MP0005085_abnormal_gallbladder_physiolo	4.65288869
4	MP0005365_abnormal_bile_salt	4.34586576
5	MP0001666_abnormal_nutrient_absorption	3.91060066
6	MP0008875_abnormal_xenobiotic_pharmacok	3.34342418
7	MP0009840_abnormal_foam_cell	3.26052364
8	MP0002138_abnormal_hepatobiliary_system	2.56654101
9	MP0004019_abnormal_vitamin_homeostasis	2.55090570
10	MP0010155_abnormal_intestine_physiology	2.48321439
11	MP0010329_abnormal_lipoprotein_level	2.34119279
12	MP0003252_abnormal_bile_duct	2.23671624
13	MP0003195_calcinosis	2.23354519
14	MP0003868_abnormal_feces_composition	2.17556808
15	MP0003806_abnormal_nucleotide_metabolis	2.05233995
16	MP0010234_abnormal_vibrissa_follicle	2.04745135
17	MP0003183_abnormal_peptide_metabolism	2.00499920
18	MP0003191_abnormal_cellular_cholesterol	1.98716780
19	MP0003303_peritoneal_inflammation	1.96142455
20	MP0005332_abnormal_amino_acid	1.89582379
21	MP0009379_abnormal_foot_pigmentation	1.71767561
22	MP0002876_abnormal_thyroid_physiology	1.69736262
23	MP0009785_altered_susceptibility_to	1.68476585
24	MP0005166_decreased_susceptibility_to	1.67114187
25	MP0005451_abnormal_body_composition	1.61724514
26	MP0009643_abnormal_urine_homeostasis	1.58380240
27	MP0001764_abnormal_homeostasis	1.49586149
28	MP0005058_abnormal_lysosome_morphology	1.48413530
29	MP0004264_abnormal_extraembryonic_tissu	1.47737544
30	MP0002118_abnormal_lipid_homeostasis	1.46002833
31	MP0000609_abnormal_liver_physiology	1.45599555
32	MP0003436_decreased_susceptibility_to	1.39413572
33	MP0003866_abnormal_defecation	1.35644382
34	MP0003724_increased_susceptibility_to	1.34589079
35	MP0009764_decreased_sensitivity_to	1.32056727
36	MP0006082_CNS_inflammation	1.30866640
37	MP0000604_amyloidosis	1.25412096
38	MP0005025_abnormal_response_to	1.22698712
39	MP0003075_altered_response_to	1.20020706
40	MP0008469_abnormal_protein_level	1.19332113
41	MP0005636_abnormal_mineral_homeostasis	1.18144346
42	MP0001845_abnormal_inflammatory_respons	1.17727879
43	MP0005387_immune_system_phenotype	1.16184504
44	MP0001790_abnormal_immune_system	1.16184504
45	MP0002148_abnormal_hypersensitivity_rea	1.14622016
46	MP0001663_abnormal_digestive_system	1.14416839
47	MP0004043_abnormal_pH_regulation	1.13828788
48	MP0005319_abnormal_enzyme/_coenzyme	1.11287168
49	MP0003879_abnormal_hair_cell	1.08656092
50	MP0001664_abnormal_digestion	1.08636672
51	MP0004782_abnormal_surfactant_physiolog	1.07193112
52	MP0010352_gastrointestinal_tract_polyps	1.06658619
53	MP0001835_abnormal_antigen_presentation	1.06502583
54	MP0005584_abnormal_enzyme/coenzyme_acti	1.05098713
55	MP0002136_abnormal_kidney_physiology	1.01402257
56	MP0000678_abnormal_parathyroid_gland	0.99459966
57	MP0005409_darkened_coat_color	0.98819608
58	MP0000490_abnormal_crypts_of	0.98307974
59	MP0001873_stomach_inflammation	0.97144740
60	MP0004147_increased_porphyrin_level	0.96325392
61	MP0000477_abnormal_intestine_morphology	0.95232774
62	MP0004858_abnormal_nervous_system	0.94801262
63	MP0001765_abnormal_ion_homeostasis	0.94143825
64	MP0001533_abnormal_skeleton_physiology	0.90041709
65	MP0005381_digestive/alimentary_phenotyp	0.88420516
66	MP0002971_abnormal_brown_adipose	0.87852603
67	MP0005535_abnormal_body_temperature	0.85180957
68	MP0002419_abnormal_innate_immunity	0.82978051
69	MP0009763_increased_sensitivity_to	0.82515980
70	MP0003300_gastrointestinal_ulcer	0.82442036
71	MP0009642_abnormal_blood_homeostasis	0.80912291
72	MP0005670_abnormal_white_adipose	0.80130023
73	MP0000249_abnormal_blood_vessel	0.79683825
74	MP0001756_abnormal_urination	0.78766003
75	MP0002132_abnormal_respiratory_system	0.77470815
76	MP0005000_abnormal_immune_tolerance	0.77062005
77	MP0005671_abnormal_response_to	0.74771851
78	MP0005448_abnormal_energy_balance	0.74354676
79	MP0004947_skin_inflammation	0.72875445
80	MP0005165_increased_susceptibility_to	0.72726544
81	MP0009333_abnormal_splenocyte_physiolog	0.72588165
82	MP0000685_abnormal_immune_system	0.72375297
83	MP0001800_abnormal_humoral_immune	0.71661193
84	MP0003329_amyloid_beta_deposits	0.70614106
85	MP0004510_myositis	0.70154890
86	MP0008004_abnormal_stomach_pH	0.65156149
87	MP0005464_abnormal_platelet_physiology	0.64604187
88	MP0002796_impaired_skin_barrier	0.63846449
89	MP0009765_abnormal_xenobiotic_induced	0.62744734
90	MP0000465_gastrointestinal_hemorrhage	0.61896844
91	MP0002998_abnormal_bone_remodeling	0.61243834
92	MP0005376_homeostasis/metabolism_phenot	0.60809676
93	MP0005023_abnormal_wound_healing	0.60583149
94	MP0009115_abnormal_fat_cell	0.59046934
95	MP0003453_abnormal_keratinocyte_physiol	0.58881822
96	MP0002723_abnormal_immune_serum	0.58555294
97	MP0001501_abnormal_sleep_pattern	0.57419487
98	MP0005164_abnormal_response_to	0.56971619
99	MP0000598_abnormal_liver_morphology	0.55940952
100	MP0000858_altered_metastatic_potential	0.55638144

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Systemic lupus erythematosus (HP:0002725)	7.42647569
2	Complement deficiency (HP:0004431)	7.02075186
3	Abnormality of monocarboxylic acid metabolism (HP:0010996)	6.94971102
4	Abnormality of glutamine family amino acid metabolism (HP:0010902)	6.63687491
5	Abnormality of complement system (HP:0005339)	5.97225504
6	Hypobetalipoproteinemia (HP:0003563)	5.43351064
7	Glomerulonephritis (HP:0000099)	5.10744090
8	Malnutrition (HP:0004395)	4.87724089
9	Deep venous thrombosis (HP:0002625)	4.74364621
10	Abnormality of aromatic amino acid family metabolism (HP:0004338)	4.41152837
11	Xanthomatosis (HP:0000991)	4.26877978
12	Hydroxyprolinuria (HP:0003080)	4.04055276
13	Abnormality of proline metabolism (HP:0010907)	4.04055276
14	Prolonged partial thromboplastin time (HP:0003645)	3.95399974
15	Fat malabsorption (HP:0002630)	3.74791830
16	Conjugated hyperbilirubinemia (HP:0002908)	3.73454001
17	Nephritis (HP:0000123)	3.72478512
18	Intrahepatic cholestasis (HP:0001406)	3.38862863
19	Recurrent gram-negative bacterial infections (HP:0005420)	3.36310724
20	Hemorrhage of the eye (HP:0011885)	3.30892707
21	Abnormality of pyrimidine metabolism (HP:0004353)	3.11385722
22	Hypolipoproteinemia (HP:0010981)	3.11110274
23	Joint hemorrhage (HP:0005261)	3.03408778
24	Hyperlipoproteinemia (HP:0010980)	3.01703750
25	Hyperactive renin-angiotensin system (HP:0000841)	2.91568321
26	Widely patent fontanelles and sutures (HP:0004492)	2.88380599
27	Alkalosis (HP:0001948)	2.87519757
28	Hyperammonemia (HP:0001987)	2.84879919
29	Steatorrhea (HP:0002570)	2.77704793
30	Abnormality of vitamin metabolism (HP:0100508)	2.76968628
31	Chronic diarrhea (HP:0002028)	2.75309147
32	Abnormality of the nasal mucosa (HP:0000433)	2.65793687
33	Decreased circulating renin level (HP:0003351)	2.63289049
34	Purpura (HP:0000979)	2.61205228
35	Nausea (HP:0002018)	2.60458309
36	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.55471542
37	Ileus (HP:0002595)	2.49877319
38	Nasal polyposis (HP:0100582)	2.45563622
39	Abnormality of serine family amino acid metabolism (HP:0010894)	2.44597274
40	Abnormality of glycine metabolism (HP:0010895)	2.44597274
41	Eczematoid dermatitis (HP:0000976)	2.42086115
42	Glycosuria (HP:0003076)	2.38849625
43	Abnormality of urine glucose concentration (HP:0011016)	2.38849625
44	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.38287745
45	Abnormality of nucleobase metabolism (HP:0010932)	2.35775361
46	Hypophosphatemia (HP:0002148)	2.34971337
47	Hyperglycinuria (HP:0003108)	2.32953674
48	Abnormality of vitamin B metabolism (HP:0004340)	2.28658194
49	Abdominal distention (HP:0003270)	2.25911936
50	Generalized aminoaciduria (HP:0002909)	2.17315443
51	Pancreatitis (HP:0001733)	2.16914976
52	Proximal tubulopathy (HP:0000114)	2.12136188
53	Confusion (HP:0001289)	2.10774640
54	Rickets (HP:0002748)	2.10141668
55	Abnormality of the common coagulation pathway (HP:0010990)	2.09971298
56	Amyloidosis (HP:0011034)	2.09255163
57	Spontaneous abortion (HP:0005268)	2.08228760
58	Acanthocytosis (HP:0001927)	2.06763524
59	Epidermoid cyst (HP:0200040)	2.06544246
60	Metabolic acidosis (HP:0001942)	2.05293203
61	Abnormality of renin-angiotensin system (HP:0000847)	2.05236953
62	Cerebral palsy (HP:0100021)	2.05202165
63	Thin bony cortex (HP:0002753)	2.04624104
64	Nephrolithiasis (HP:0000787)	2.04567715
65	Metabolic alkalosis (HP:0200114)	2.03398156
66	Vascular calcification (HP:0004934)	2.02124683
67	Pigmentary retinal degeneration (HP:0001146)	2.02007357
68	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.01965823
69	Wide cranial sutures (HP:0010537)	2.01322864
70	Abnormality of purine metabolism (HP:0004352)	2.01120613
71	Hypotension (HP:0002615)	1.99883866
72	Potter facies (HP:0002009)	1.96124491
73	Facial shape deformation (HP:0011334)	1.96124491
74	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.93998997
75	Irritability (HP:0000737)	1.93273673
76	Protuberant abdomen (HP:0001538)	1.92483111
77	Hyperuricemia (HP:0002149)	1.91782945
78	Increased purine levels (HP:0004368)	1.91782945
79	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.89666656
80	Dicarboxylic aciduria (HP:0003215)	1.89666656
81	Hyperphosphaturia (HP:0003109)	1.89370965
82	Flat acetabular roof (HP:0003180)	1.87559327
83	Abnormal enzyme/coenzyme activity (HP:0012379)	1.87224010
84	Pulmonary embolism (HP:0002204)	1.85915208
85	Abnormality of alkaline phosphatase activity (HP:0004379)	1.85590612
86	Gingival bleeding (HP:0000225)	1.84988982
87	Mucopolysacchariduria (HP:0008155)	1.83646488
88	Urinary glycosaminoglycan excretion (HP:0003541)	1.83646488
89	Abnormality of iron homeostasis (HP:0011031)	1.83589384
90	Delayed CNS myelination (HP:0002188)	1.82814502
91	Gout (HP:0001997)	1.81400160
92	Thrombophlebitis (HP:0004418)	1.81099054
93	Joint swelling (HP:0001386)	1.80448420
94	Congenital sensorineural hearing impairment (HP:0008527)	1.80423906
95	Focal segmental glomerulosclerosis (HP:0000097)	1.79649362
96	Elevated alkaline phosphatase (HP:0003155)	1.78057844
97	Orchitis (HP:0100796)	1.77843137
98	Increased serum ferritin (HP:0003281)	1.77512239
99	Abnormal urine phosphate concentration (HP:0012599)	1.75286306
100	Abnormal respiratory epithelium morphology (HP:0012253)	1.74764843

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ERN1	5.16586517
2	ACVR1B	4.83553449
3	RIPK1	3.90957620
4	MST1R	3.88831643
5	EPHA2	3.10491740
6	FGFR4	2.64474334
7	TYK2	2.38432003
8	PRKG2	2.17023162
9	TBK1	1.93626408
10	DDR2	1.93479381
11	IRAK3	1.89921257
12	MAP3K3	1.87370237
13	EPHA3	1.66603341
14	MATK	1.59583705
15	MAPK15	1.59133532
16	PIK3CA	1.58517574
17	MAP3K2	1.54149892
18	EPHB2	1.48304480
19	MAP4K1	1.46640360
20	MAP3K11	1.45079062
21	CDC42BPA	1.44670868
22	TAOK1	1.39407157
23	RIPK4	1.38584601
24	EPHB1	1.38210737
25	STK24	1.37849058
26	PRPF4B	1.33030256
27	PTK6	1.32650041
28	MAP3K1	1.32003268
29	CSK	1.25515691
30	TESK1	1.23873310
31	MAP3K12	1.23317480
32	FGFR3	1.23215044
33	MAP3K14	1.21299716
34	IKBKE	1.20900993
35	TESK2	1.20468943
36	MET	1.19575760
37	TRIB3	1.11000605
38	MYLK	1.07234143
39	MST4	1.05054233
40	PDPK1	1.03775103
41	LMTK2	1.02325973
42	ZAP70	0.99360522
43	TAOK2	0.97872386
44	ABL2	0.95836546
45	TGFBR2	0.92049619
46	PRKAA2	0.88952080
47	TXK	0.88521161
48	GRK6	0.86726764
49	MAP2K2	0.85928153
50	SIK1	0.84116553
51	JAK1	0.84030510
52	MAP2K6	0.81635418
53	DYRK1B	0.78253500
54	BLK	0.77720693
55	STK39	0.77662625
56	PDK2	0.77544504
57	MAPK11	0.77243722
58	MAP3K10	0.76836189
59	PRKACG	0.76482174
60	PIM2	0.75625731
61	GRK7	0.72435572
62	FER	0.71814489
63	JAK3	0.71190871
64	NME2	0.71115069
65	MAPKAPK3	0.71033662
66	IRAK4	0.70878739
67	IRAK1	0.70548335
68	JAK2	0.70394446
69	NLK	0.67627140
70	ERBB2	0.66587110
71	PDK1	0.66303820
72	OXSR1	0.61150155
73	IKBKB	0.60605175
74	SMG1	0.58125213
75	CSF1R	0.56819340
76	BMPR2	0.56774194
77	PDGFRA	0.53556260
78	FGR	0.51245043
79	PAK4	0.50412653
80	LYN	0.50040471
81	SRC	0.47658219
82	PRKCA	0.46907737
83	KIT	0.45129864
84	PRKCZ	0.44332446
85	CDK6	0.44139225
86	MAPK7	0.43542080
87	KDR	0.40072020
88	CHUK	0.37715089
89	IGF1R	0.37484356
90	SYK	0.36868388
91	CAMK2G	0.36728819
92	BMX	0.36713764
93	FYN	0.34866824
94	PRKCD	0.34088135
95	ADRBK2	0.33733829
96	LCK	0.33021346
97	RET	0.31028260
98	CAMK2D	0.29420267
99	LRRK2	0.28416668
100	PRKCQ	0.27622740

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	3.65003515
2	Cyanoamino acid metabolism_Homo sapiens_hsa00460	3.37065024
3	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.90133360
4	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.78681435
5	Retinol metabolism_Homo sapiens_hsa00830	2.76168926
6	Arginine biosynthesis_Homo sapiens_hsa00220	2.74404968
7	Fat digestion and absorption_Homo sapiens_hsa04975	2.74331304
8	Chemical carcinogenesis_Homo sapiens_hsa05204	2.74325837
9	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.70111074
10	Complement and coagulation cascades_Homo sapiens_hsa04610	2.69594732
11	Histidine metabolism_Homo sapiens_hsa00340	2.54633531
12	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.42594086
13	Drug metabolism - other enzymes_Homo sapiens_hsa00983	2.21047516
14	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.20969663
15	Fatty acid degradation_Homo sapiens_hsa00071	2.14691267
16	Phenylalanine metabolism_Homo sapiens_hsa00360	2.13065651
17	Vitamin digestion and absorption_Homo sapiens_hsa04977	2.06397424
18	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.05870048
19	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.01980497
20	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.98706204
21	Sulfur metabolism_Homo sapiens_hsa00920	1.91824269
22	Renin-angiotensin system_Homo sapiens_hsa04614	1.87041311
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.84655200
24	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.78595514
25	Tyrosine metabolism_Homo sapiens_hsa00350	1.72806807
26	PPAR signaling pathway_Homo sapiens_hsa03320	1.70252517
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.63255556
28	Bile secretion_Homo sapiens_hsa04976	1.60683665
29	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.49944603
30	Mineral absorption_Homo sapiens_hsa04978	1.49740298
31	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.45414432
32	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.43902600
33	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.40165419
34	Asthma_Homo sapiens_hsa05310	1.23500150
35	Arginine and proline metabolism_Homo sapiens_hsa00330	1.23323253
36	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.13670295
37	Prion diseases_Homo sapiens_hsa05020	1.08640401
38	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.05293600
39	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.98821734
40	Peroxisome_Homo sapiens_hsa04146	0.98640317
41	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.96558597
42	Other glycan degradation_Homo sapiens_hsa00511	0.96039740
43	Allograft rejection_Homo sapiens_hsa05330	0.95349709
44	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.94216224
45	Pertussis_Homo sapiens_hsa05133	0.90333441
46	Butanoate metabolism_Homo sapiens_hsa00650	0.90263032
47	Galactose metabolism_Homo sapiens_hsa00052	0.88218668
48	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.87583360
49	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.87496822
50	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.86860599
51	Protein digestion and absorption_Homo sapiens_hsa04974	0.85838884
52	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.84442361
53	Glycerolipid metabolism_Homo sapiens_hsa00561	0.82902399
54	Glutathione metabolism_Homo sapiens_hsa00480	0.81327878
55	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.80908543
56	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.77610328
57	Graft-versus-host disease_Homo sapiens_hsa05332	0.77242465
58	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.72570320
59	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.71592880
60	beta-Alanine metabolism_Homo sapiens_hsa00410	0.67408089
61	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.63462972
62	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.62430628
63	Type I diabetes mellitus_Homo sapiens_hsa04940	0.61363937
64	Sulfur relay system_Homo sapiens_hsa04122	0.55101786
65	Fatty acid metabolism_Homo sapiens_hsa01212	0.54621755
66	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.53221943
67	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.47926831
68	Carbon metabolism_Homo sapiens_hsa01200	0.46222634
69	Leishmaniasis_Homo sapiens_hsa05140	0.45982863
70	ABC transporters_Homo sapiens_hsa02010	0.45336079
71	Sphingolipid metabolism_Homo sapiens_hsa00600	0.41310190
72	Pyruvate metabolism_Homo sapiens_hsa00620	0.39050361
73	Ether lipid metabolism_Homo sapiens_hsa00565	0.38402657
74	Antigen processing and presentation_Homo sapiens_hsa04612	0.37826878
75	African trypanosomiasis_Homo sapiens_hsa05143	0.36094338
76	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.34775919
77	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.31753809
78	Insulin resistance_Homo sapiens_hsa04931	0.31102248
79	Rheumatoid arthritis_Homo sapiens_hsa05323	0.29842663
80	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.29469910
81	Folate biosynthesis_Homo sapiens_hsa00790	0.29466680
82	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.28565421
83	Pentose phosphate pathway_Homo sapiens_hsa00030	0.27779236
84	Metabolic pathways_Homo sapiens_hsa01100	0.27653623
85	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.26382323
86	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.26072934
87	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.26057806
88	Hepatitis C_Homo sapiens_hsa05160	0.23662257
89	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.23270513
90	Pancreatic secretion_Homo sapiens_hsa04972	0.22950975
91	Amoebiasis_Homo sapiens_hsa05146	0.22658564
92	Lysosome_Homo sapiens_hsa04142	0.20711155
93	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.20273871
94	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.18445664
95	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.16514572
96	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.15961692
97	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.15224350
98	Tuberculosis_Homo sapiens_hsa05152	0.14562138
99	TNF signaling pathway_Homo sapiens_hsa04668	0.14231898
100	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.13643343

CCL15-CCL14

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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