CCL16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for lymphocytes and monocytes but not for neutrophils. This cytokine also shows a potent myelosuppressive activity and suppresses proliferation of myeloid progenitor cells. The expression of this gene is upregulated by IL-10. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug catabolic process (GO:0042737)7.93661249
2exogenous drug catabolic process (GO:0042738)7.60959155
3glyoxylate metabolic process (GO:0046487)7.38070676
4oxidative demethylation (GO:0070989)6.04972059
5regulation of fibrinolysis (GO:0051917)5.97220372
6negative regulation of fibrinolysis (GO:0051918)5.83912214
7serine family amino acid catabolic process (GO:0009071)5.59040317
8epoxygenase P450 pathway (GO:0019373)5.57735632
9L-phenylalanine catabolic process (GO:0006559)5.54455007
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.54455007
11phenylpropanoid metabolic process (GO:0009698)5.34892520
12cellular glucuronidation (GO:0052695)5.34452173
13bile acid biosynthetic process (GO:0006699)5.31739773
14aromatic amino acid family catabolic process (GO:0009074)5.31090308
15uronic acid metabolic process (GO:0006063)5.19546509
16glucuronate metabolic process (GO:0019585)5.19546509
17tryptophan catabolic process (GO:0006569)5.10321686
18indole-containing compound catabolic process (GO:0042436)5.10321686
19indolalkylamine catabolic process (GO:0046218)5.10321686
20regulation of triglyceride catabolic process (GO:0010896)5.06631212
21drug metabolic process (GO:0017144)5.03132192
22omega-hydroxylase P450 pathway (GO:0097267)4.90166129
23alkaloid metabolic process (GO:0009820)4.82598585
24L-phenylalanine metabolic process (GO:0006558)4.75866472
25erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.75866472
26regulation of protein activation cascade (GO:2000257)4.71792176
27bile acid metabolic process (GO:0008206)4.70641676
28tryptophan metabolic process (GO:0006568)4.68980510
29glycine metabolic process (GO:0006544)4.65295830
30cellular ketone body metabolic process (GO:0046950)4.57501439
31bile acid and bile salt transport (GO:0015721)4.53981552
32negative regulation of sterol transport (GO:0032372)4.51291432
33negative regulation of cholesterol transport (GO:0032375)4.51291432
34fibrinolysis (GO:0042730)4.50031283
35S-adenosylmethionine metabolic process (GO:0046500)4.47950455
36blood coagulation, intrinsic pathway (GO:0007597)4.41158479
37arginine metabolic process (GO:0006525)4.39145590
38protein carboxylation (GO:0018214)4.36149381
39peptidyl-glutamic acid carboxylation (GO:0017187)4.36149381
40amino-acid betaine metabolic process (GO:0006577)4.32858230
41complement activation, alternative pathway (GO:0006957)4.28732844
42regulation of complement activation (GO:0030449)4.27368324
43acylglycerol homeostasis (GO:0055090)4.22209582
44triglyceride homeostasis (GO:0070328)4.22209582
45urea metabolic process (GO:0019627)4.18187459
46indolalkylamine metabolic process (GO:0006586)4.10278692
47ethanol oxidation (GO:0006069)4.04631040
48ketone body metabolic process (GO:1902224)4.03012897
49kynurenine metabolic process (GO:0070189)4.01520175
50serine family amino acid metabolic process (GO:0009069)3.91620487
51heme transport (GO:0015886)3.90030376
52aromatic amino acid family metabolic process (GO:0009072)3.86370551
53tyrosine metabolic process (GO:0006570)3.80229870
54nitrogen cycle metabolic process (GO:0071941)3.75541931
55L-methionine salvage (GO:0071267)3.73050613
56L-methionine biosynthetic process (GO:0071265)3.73050613
57amino acid salvage (GO:0043102)3.73050613
58high-density lipoprotein particle remodeling (GO:0034375)3.63254301
59flavonoid metabolic process (GO:0009812)3.62893384
60triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.61254042
61alpha-amino acid catabolic process (GO:1901606)3.59607349
62cellular biogenic amine catabolic process (GO:0042402)3.58882904
63amine catabolic process (GO:0009310)3.58882904
64behavioral response to nicotine (GO:0035095)3.51744039
65negative regulation of blood coagulation (GO:0030195)3.50198711
66negative regulation of hemostasis (GO:1900047)3.50198711
67intestinal cholesterol absorption (GO:0030299)3.48585894
68cysteine metabolic process (GO:0006534)3.47237090
69plasma lipoprotein particle remodeling (GO:0034369)3.40851785
70protein-lipid complex remodeling (GO:0034368)3.40851785
71macromolecular complex remodeling (GO:0034367)3.40851785
72steroid catabolic process (GO:0006706)3.39935027
73ethanol metabolic process (GO:0006067)3.36493767
74negative regulation of lipase activity (GO:0060192)3.36037409
75urea cycle (GO:0000050)3.34988588
76xenobiotic metabolic process (GO:0006805)3.32090308
77reverse cholesterol transport (GO:0043691)3.28442296
78phospholipid efflux (GO:0033700)3.25031330
79arginine catabolic process (GO:0006527)3.24724086
80water-soluble vitamin biosynthetic process (GO:0042364)3.23460129
81drug transmembrane transport (GO:0006855)3.23114216
82regulation of lipoprotein particle clearance (GO:0010984)3.20723275
83negative regulation of coagulation (GO:0050819)3.19223420
84pyrimidine nucleobase catabolic process (GO:0006208)3.18330268
85regulation of plasminogen activation (GO:0010755)3.17815440
86cellular amino acid catabolic process (GO:0009063)3.16711939
87vitamin biosynthetic process (GO:0009110)3.15180608
88aldehyde catabolic process (GO:0046185)3.13088604
89polyketide metabolic process (GO:0030638)3.12602753
90doxorubicin metabolic process (GO:0044598)3.12602753
91daunorubicin metabolic process (GO:0044597)3.12602753
92indole-containing compound metabolic process (GO:0042430)3.12573244
93negative regulation of wound healing (GO:0061045)3.10941359
94protein activation cascade (GO:0072376)3.07010363
95fat-soluble vitamin biosynthetic process (GO:0042362)3.06901088
96cholesterol efflux (GO:0033344)3.06482791
97negative regulation of protein activation cascade (GO:2000258)3.01540337
98benzene-containing compound metabolic process (GO:0042537)3.00736825
99hormone catabolic process (GO:0042447)2.99126176
100dopamine transport (GO:0015872)2.94461606

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_23403033_ChIP-Seq_LIVER_Mouse4.30803668
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.75452713
3ZNF274_21170338_ChIP-Seq_K562_Hela3.31670843
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.82431617
5RXR_22158963_ChIP-Seq_LIVER_Mouse2.70970418
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.61445296
7VDR_22108803_ChIP-Seq_LS180_Human2.54684797
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.49392032
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.38962553
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.38649326
11GBX2_23144817_ChIP-Seq_PC3_Human2.37146914
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.35616673
13IGF1R_20145208_ChIP-Seq_DFB_Human2.22060806
14EZH2_22144423_ChIP-Seq_EOC_Human2.16379421
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.07438112
16POU3F2_20337985_ChIP-ChIP_501MEL_Human1.99613911
17ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96348165
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88455271
19IRF1_19129219_ChIP-ChIP_H3396_Human1.86919902
20ER_23166858_ChIP-Seq_MCF-7_Human1.86118890
21NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.84369539
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.77729352
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.76068263
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70369886
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59589678
26BCAT_22108803_ChIP-Seq_LS180_Human1.58579051
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57992632
28TAF15_26573619_Chip-Seq_HEK293_Human1.52971163
29P300_19829295_ChIP-Seq_ESCs_Human1.50692352
30PIAS1_25552417_ChIP-Seq_VCAP_Human1.50243678
31FUS_26573619_Chip-Seq_HEK293_Human1.48705908
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45731477
33NFE2_27457419_Chip-Seq_LIVER_Mouse1.42663531
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42437572
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42153821
36FOXA1_27270436_Chip-Seq_PROSTATE_Human1.37535797
37FOXA1_25329375_ChIP-Seq_VCAP_Human1.37535797
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37458280
39* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.37122989
40NANOG_19829295_ChIP-Seq_ESCs_Human1.35953587
41SOX2_19829295_ChIP-Seq_ESCs_Human1.35953587
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.33873448
43AR_20517297_ChIP-Seq_VCAP_Human1.33798908
44STAT3_23295773_ChIP-Seq_U87_Human1.33746903
45ETV2_25802403_ChIP-Seq_MESCs_Mouse1.33038736
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32641734
47CBP_20019798_ChIP-Seq_JUKART_Human1.32641734
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28567601
49HTT_18923047_ChIP-ChIP_STHdh_Human1.28134891
50* GATA3_21878914_ChIP-Seq_MCF-7_Human1.27400334
51BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.26820707
52NCOR_22424771_ChIP-Seq_293T_Human1.26561518
53GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26154500
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25974492
55KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21375218
56AR_25329375_ChIP-Seq_VCAP_Human1.21245967
57EWS_26573619_Chip-Seq_HEK293_Human1.19953030
58CRX_20693478_ChIP-Seq_RETINA_Mouse1.19863519
59FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19616836
60TCF4_22108803_ChIP-Seq_LS180_Human1.19216745
61TCF4_23295773_ChIP-Seq_U87_Human1.18499700
62CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18456088
63EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17395749
64IRF8_22096565_ChIP-ChIP_GC-B_Human1.16818097
65* HNF4A_19822575_ChIP-Seq_HepG2_Human1.14280950
66TP53_22573176_ChIP-Seq_HFKS_Human1.13839980
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10400593
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.09325203
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09216915
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09160381
71SMAD4_21799915_ChIP-Seq_A2780_Human1.08754915
72REST_21632747_ChIP-Seq_MESCs_Mouse1.07983967
73SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07200492
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05960705
75SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05405128
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04651657
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04651657
78P53_21459846_ChIP-Seq_SAOS-2_Human1.03763042
79SMAD4_21741376_ChIP-Seq_EPCs_Human1.03340098
80AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01387743
81ERA_21632823_ChIP-Seq_H3396_Human1.00749194
82EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00556718
83RUNX2_22187159_ChIP-Seq_PCA_Human1.00171330
84STAT3_18555785_Chip-Seq_ESCs_Mouse0.99208566
85* FOXH1_21741376_ChIP-Seq_EPCs_Human0.99161851
86SMAD3_21741376_ChIP-Seq_EPCs_Human0.98395290
87CDX2_22108803_ChIP-Seq_LS180_Human0.98300117
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97530678
89MYC_19829295_ChIP-Seq_ESCs_Human0.97437573
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97125211
91OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96843908
92HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96384650
93TP53_16413492_ChIP-PET_HCT116_Human0.96325565
94P53_22387025_ChIP-Seq_ESCs_Mouse0.96180554
95AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.95713758
96TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94852219
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94790876
98* TAF2_19829295_ChIP-Seq_ESCs_Human0.94252521
99PHF8_20622853_ChIP-Seq_HELA_Human0.93361103
100HOXB7_26014856_ChIP-Seq_BT474_Human0.93343208

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.40316953
2MP0005085_abnormal_gallbladder_physiolo5.34385316
3MP0005360_urolithiasis5.28484811
4MP0003195_calcinosis5.21844717
5MP0005365_abnormal_bile_salt4.96032228
6MP0008875_abnormal_xenobiotic_pharmacok4.56033011
7MP0002138_abnormal_hepatobiliary_system4.53236973
8MP0002876_abnormal_thyroid_physiology3.29356841
9MP0003252_abnormal_bile_duct3.26936369
10MP0003868_abnormal_feces_composition2.83338538
11MP0009697_abnormal_copulation2.79132158
12MP0001666_abnormal_nutrient_absorption2.50296938
13MP0010329_abnormal_lipoprotein_level2.41411521
14MP0005332_abnormal_amino_acid2.18535462
15MP0001764_abnormal_homeostasis1.94448289
16MP0003806_abnormal_nucleotide_metabolis1.86306690
17MP0008872_abnormal_physiological_respon1.63059873
18MP0005551_abnormal_eye_electrophysiolog1.55202413
19MP0003011_delayed_dark_adaptation1.54582357
20MP0004019_abnormal_vitamin_homeostasis1.44678240
21MP0002118_abnormal_lipid_homeostasis1.43173918
22MP0009840_abnormal_foam_cell1.42837958
23MP0005645_abnormal_hypothalamus_physiol1.26215756
24MP0001986_abnormal_taste_sensitivity1.26152369
25MP0006292_abnormal_olfactory_placode1.25403983
26MP0005084_abnormal_gallbladder_morpholo1.23768709
27MP0000569_abnormal_digit_pigmentation1.22986607
28MP0000609_abnormal_liver_physiology1.18257044
29MP0003646_muscle_fatigue1.15978910
30MP0004142_abnormal_muscle_tone1.12947782
31MP0002638_abnormal_pupillary_reflex1.11751530
32MP0005646_abnormal_pituitary_gland1.08265487
33MP0001968_abnormal_touch/_nociception1.04116611
34MP0009745_abnormal_behavioral_response1.00790792
35MP0005187_abnormal_penis_morphology0.99626363
36MP0002102_abnormal_ear_morphology0.97710085
37MP0010386_abnormal_urinary_bladder0.96067842
38MP0003718_maternal_effect0.94428007
39MP0009643_abnormal_urine_homeostasis0.91497832
40MP0003638_abnormal_response/metabolism_0.91222164
41MP0002837_dystrophic_cardiac_calcinosis0.90896794
42MP0008877_abnormal_DNA_methylation0.89582206
43MP0004043_abnormal_pH_regulation0.88723255
44MP0000372_irregular_coat_pigmentation0.88594118
45MP0009764_decreased_sensitivity_to0.87655580
46MP0002928_abnormal_bile_duct0.87178612
47MP0005319_abnormal_enzyme/_coenzyme0.86098206
48MP0001501_abnormal_sleep_pattern0.85853601
49MP0005636_abnormal_mineral_homeostasis0.85387934
50MP0009046_muscle_twitch0.84597425
51MP0005083_abnormal_biliary_tract0.83693668
52MP0005408_hypopigmentation0.82820976
53MP0005253_abnormal_eye_physiology0.77577414
54MP0002272_abnormal_nervous_system0.76972749
55MP0003186_abnormal_redox_activity0.76315320
56MP0004133_heterotaxia0.75858016
57MP0002653_abnormal_ependyma_morphology0.73742071
58MP0009642_abnormal_blood_homeostasis0.73693295
59MP0005410_abnormal_fertilization0.73487609
60MP0003136_yellow_coat_color0.72280179
61MP0002064_seizures0.72222945
62MP0003880_abnormal_central_pattern0.71362387
63MP0002736_abnormal_nociception_after0.70932829
64MP0002938_white_spotting0.70506751
65MP0005376_homeostasis/metabolism_phenot0.70051352
66MP0006072_abnormal_retinal_apoptosis0.69960012
67MP0005584_abnormal_enzyme/coenzyme_acti0.69093433
68MP0005395_other_phenotype0.68505628
69MP0005535_abnormal_body_temperature0.68423094
70MP0001485_abnormal_pinna_reflex0.66532818
71MP0005448_abnormal_energy_balance0.66071218
72MP0003879_abnormal_hair_cell0.65348825
73MP0006276_abnormal_autonomic_nervous0.65268170
74MP0005379_endocrine/exocrine_gland_phen0.64476024
75MP0004130_abnormal_muscle_cell0.63183070
76MP0001324_abnormal_eye_pigmentation0.61473594
77MP0002078_abnormal_glucose_homeostasis0.60510416
78MP0005266_abnormal_metabolism0.60171924
79MP0003959_abnormal_lean_body0.59928597
80MP0006036_abnormal_mitochondrial_physio0.59798066
81MP0005195_abnormal_posterior_eye0.59041507
82MP0002735_abnormal_chemical_nociception0.57689130
83MP0002282_abnormal_trachea_morphology0.57175827
84MP0004147_increased_porphyrin_level0.56768545
85MP0000598_abnormal_liver_morphology0.55889310
86MP0004145_abnormal_muscle_electrophysio0.55887557
87MP0000230_abnormal_systemic_arterial0.55845673
88MP0003953_abnormal_hormone_level0.55678982
89MP0001661_extended_life_span0.54609158
90MP0000427_abnormal_hair_cycle0.54396839
91MP0005171_absent_coat_pigmentation0.54011436
92MP0001502_abnormal_circadian_rhythm0.51649412
93MP0005167_abnormal_blood-brain_barrier0.51075066
94MP0002733_abnormal_thermal_nociception0.50981991
95MP0002572_abnormal_emotion/affect_behav0.50746975
96MP0005386_behavior/neurological_phenoty0.50619584
97MP0004924_abnormal_behavior0.50619584
98MP0004885_abnormal_endolymph0.50394923
99MP0002090_abnormal_vision0.49688745
100MP0001905_abnormal_dopamine_level0.49338365

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.16776524
2Abnormality of monocarboxylic acid metabolism (HP:0010996)6.04311489
3Prolonged partial thromboplastin time (HP:0003645)6.00644661
4Hypobetalipoproteinemia (HP:0003563)5.24453877
5Abnormality of aromatic amino acid family metabolism (HP:0004338)4.58943012
6Complement deficiency (HP:0004431)4.04205390
7Hyperglycinemia (HP:0002154)3.92803590
8Hyperlipoproteinemia (HP:0010980)3.88409032
9Abnormality of glutamine family amino acid metabolism (HP:0010902)3.66972437
10Hyperglycinuria (HP:0003108)3.61252122
11Joint hemorrhage (HP:0005261)3.49158143
12Congenital stationary night blindness (HP:0007642)3.47781901
13Abnormality of serine family amino acid metabolism (HP:0010894)3.46060146
14Abnormality of glycine metabolism (HP:0010895)3.46060146
15Conjugated hyperbilirubinemia (HP:0002908)3.36938528
16Xanthomatosis (HP:0000991)3.33338223
17Abnormality of serum amino acid levels (HP:0003112)3.26163065
18Abnormal biliary tract physiology (HP:0012439)3.23485629
19Bile duct proliferation (HP:0001408)3.23485629
20Abnormality of pyrimidine metabolism (HP:0004353)3.20261051
21Intrahepatic cholestasis (HP:0001406)3.19058330
22Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.16523372
23Abnormality of alanine metabolism (HP:0010916)3.16523372
24Hyperalaninemia (HP:0003348)3.16523372
25Fair hair (HP:0002286)3.15107274
26Generalized aminoaciduria (HP:0002909)3.11479312
27Pancreatic cysts (HP:0001737)3.06345293
28Delayed CNS myelination (HP:0002188)2.99381384
29Hyperventilation (HP:0002883)2.91980850
30Ketosis (HP:0001946)2.81263705
31Abnormality of midbrain morphology (HP:0002418)2.80685939
32Molar tooth sign on MRI (HP:0002419)2.80685939
33Glycosuria (HP:0003076)2.79173426
34Abnormality of urine glucose concentration (HP:0011016)2.79173426
35Abnormality of complement system (HP:0005339)2.78490879
36Type II lissencephaly (HP:0007260)2.77125526
37Systemic lupus erythematosus (HP:0002725)2.76248359
38Hyperammonemia (HP:0001987)2.76094056
39Hypolipoproteinemia (HP:0010981)2.68058927
40Pancreatic fibrosis (HP:0100732)2.63121257
41True hermaphroditism (HP:0010459)2.60952817
42Abnormality of the renal cortex (HP:0011035)2.59661448
43Epidermoid cyst (HP:0200040)2.53285190
44Abolished electroretinogram (ERG) (HP:0000550)2.53094568
45Chronic hepatic failure (HP:0100626)2.50813412
46Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.49356648
47Metabolic acidosis (HP:0001942)2.47825477
48Spontaneous abortion (HP:0005268)2.47261864
49Glomerulonephritis (HP:0000099)2.45867282
50Nephronophthisis (HP:0000090)2.39899803
51Hypothermia (HP:0002045)2.35933658
52Renal cortical cysts (HP:0000803)2.35598224
53Attenuation of retinal blood vessels (HP:0007843)2.34295059
54Abnormality of proline metabolism (HP:0010907)2.32077752
55Hydroxyprolinuria (HP:0003080)2.32077752
56Arthropathy (HP:0003040)2.31319478
57Generalized hypopigmentation of hair (HP:0011358)2.30586518
58Pendular nystagmus (HP:0012043)2.29865592
59Lethargy (HP:0001254)2.28323877
60Abnormality of aspartate family amino acid metabolism (HP:0010899)2.28267852
61Alkalosis (HP:0001948)2.25066587
62Reduced antithrombin III activity (HP:0001976)2.21713668
63Ketoacidosis (HP:0001993)2.20468056
64Decreased central vision (HP:0007663)2.19347437
65Hyperphosphaturia (HP:0003109)2.12596613
66Osteomalacia (HP:0002749)2.12354542
67Inability to walk (HP:0002540)2.10650761
68Chorioretinal atrophy (HP:0000533)2.09088712
69Decreased electroretinogram (ERG) amplitude (HP:0000654)2.07897795
70Abnormality of vitamin metabolism (HP:0100508)2.06463309
71Fat malabsorption (HP:0002630)2.05984489
72Abnormality of the renal medulla (HP:0100957)2.02846122
73Abnormality of the common coagulation pathway (HP:0010990)2.00626576
74Increased corneal curvature (HP:0100692)1.95273743
75Keratoconus (HP:0000563)1.95273743
76Abnormality of methionine metabolism (HP:0010901)1.94396563
77Tubular atrophy (HP:0000092)1.94114247
78Nephritis (HP:0000123)1.93882509
79Proximal tubulopathy (HP:0000114)1.89296585
80Acute encephalopathy (HP:0006846)1.88997750
81Cerebral edema (HP:0002181)1.88762771
82Rickets (HP:0002748)1.88175883
83Cystic liver disease (HP:0006706)1.80259089
84Abnormality of nucleobase metabolism (HP:0010932)1.79177777
85Large for gestational age (HP:0001520)1.78747283
86Cerebellar dysplasia (HP:0007033)1.77027533
87Steatorrhea (HP:0002570)1.75922472
88Male pseudohermaphroditism (HP:0000037)1.75164389
89Abnormality of transition element cation homeostasis (HP:0011030)1.74247706
90Abnormality of sulfur amino acid metabolism (HP:0004339)1.73545589
91Abnormal drinking behavior (HP:0030082)1.73134781
92Polydipsia (HP:0001959)1.73134781
93Abnormal rod and cone electroretinograms (HP:0008323)1.72041083
943-Methylglutaconic aciduria (HP:0003535)1.69471360
95Azoospermia (HP:0000027)1.69363861
96Progressive inability to walk (HP:0002505)1.69277849
97Pigmentary retinal degeneration (HP:0001146)1.68832421
98Gaze-evoked nystagmus (HP:0000640)1.68452569
99Medial flaring of the eyebrow (HP:0010747)1.67252848
100Irritability (HP:0000737)1.65811914

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.11383493
2ADRBK23.77519659
3BMPR1B3.30746416
4ZAK3.04991590
5ACVR1B3.00120657
6PINK12.89924046
7MAP4K22.89053163
8TLK12.80570681
9TAOK32.72918769
10GRK12.54129872
11INSRR2.38878528
12WNK32.37367058
13WNK42.33629548
14CASK1.93155559
15MAP3K41.68834706
16MAPK131.66861882
17CAMKK21.66014251
18DAPK21.65079798
19MAPKAPK31.56082309
20NUAK11.55297052
21BCKDK1.45412949
22PRKCG1.43360680
23EPHA31.34672123
24PIK3CG1.31518753
25PIK3CA1.29183949
26OXSR11.28814563
27TNIK1.27193009
28STK391.24663774
29ADRBK11.24472063
30NTRK31.20531883
31PRKCE1.08274475
32DYRK21.06154089
33PAK31.01830134
34MAP2K71.01572843
35TGFBR11.00252896
36VRK10.92817827
37MAP2K60.91139317
38TXK0.91105813
39TIE10.87957650
40MARK10.85482416
41STK38L0.82635225
42RPS6KA50.80119279
43PRKCQ0.78524851
44PHKG10.76976347
45PHKG20.76976347
46BRSK20.75942828
47IKBKB0.75760792
48MUSK0.75427762
49IRAK10.73784826
50PRKAA20.73650323
51PRKACG0.73076204
52OBSCN0.70537576
53MAP2K40.70503685
54PRKACA0.70118265
55PNCK0.68675238
56PRKAA10.67730571
57PTK2B0.67609892
58MAPK150.64344974
59EPHA40.62938620
60PRKCZ0.61907420
61ERBB20.59410781
62MAPKAPK50.59133045
63TEC0.54967321
64CDK80.54878764
65PRKCI0.54396952
66TNK20.53532613
67CHUK0.53412031
68CSNK1D0.53250595
69PRKCA0.51175843
70PRKG10.50840639
71CSNK1G10.50811464
72MAP2K20.50374713
73CSNK1G20.49933366
74PKN10.49600844
75MAP2K10.49318171
76CSNK1G30.48384464
77IGF1R0.47400007
78CAMK2A0.47329056
79CSNK1A10.47126854
80PLK20.45563160
81MKNK20.45270322
82MAPK110.44940794
83TRPM70.44085560
84KIT0.42570517
85CSNK1A1L0.38817109
86BCR0.38020381
87CAMK1D0.37920057
88NLK0.37573073
89NTRK20.34860691
90CAMKK10.34153295
91CAMK40.33389013
92PRKCB0.31858029
93ERBB30.31002537
94GRK70.30977856
95SIK20.27891054
96CAMK10.27666350
97PRKCH0.27525146
98ITK0.26512558
99PRKACB0.25658248
100RPS6KA30.24976404

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.06216676
2Caffeine metabolism_Homo sapiens_hsa002323.75981648
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.40684162
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.12565738
5Retinol metabolism_Homo sapiens_hsa008303.04749915
6Chemical carcinogenesis_Homo sapiens_hsa052042.81719946
7Steroid hormone biosynthesis_Homo sapiens_hsa001402.76303388
8Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.70844439
9Complement and coagulation cascades_Homo sapiens_hsa046102.70640586
10Linoleic acid metabolism_Homo sapiens_hsa005912.64311197
11Butanoate metabolism_Homo sapiens_hsa006502.59067381
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.55618566
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.51268471
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.38980046
15Tryptophan metabolism_Homo sapiens_hsa003802.22802862
16Drug metabolism - other enzymes_Homo sapiens_hsa009832.15751984
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.98856034
18Fatty acid degradation_Homo sapiens_hsa000711.91394611
19Arginine biosynthesis_Homo sapiens_hsa002201.87537821
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.82424395
21Peroxisome_Homo sapiens_hsa041461.80245966
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75838533
23Bile secretion_Homo sapiens_hsa049761.70978288
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70839262
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68974650
26Histidine metabolism_Homo sapiens_hsa003401.68372419
27Phenylalanine metabolism_Homo sapiens_hsa003601.64608916
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.63324489
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.59616172
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.55757502
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.45748117
32Arachidonic acid metabolism_Homo sapiens_hsa005901.42834811
33Tyrosine metabolism_Homo sapiens_hsa003501.42116608
34beta-Alanine metabolism_Homo sapiens_hsa004101.37004717
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.26769328
36Fat digestion and absorption_Homo sapiens_hsa049751.26076777
37Sulfur metabolism_Homo sapiens_hsa009201.23666182
38Starch and sucrose metabolism_Homo sapiens_hsa005001.22791796
39PPAR signaling pathway_Homo sapiens_hsa033201.20613564
40Propanoate metabolism_Homo sapiens_hsa006401.15312237
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.14110378
42Selenocompound metabolism_Homo sapiens_hsa004501.12784710
43One carbon pool by folate_Homo sapiens_hsa006701.04668508
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02779573
45Nitrogen metabolism_Homo sapiens_hsa009101.01896447
46Sulfur relay system_Homo sapiens_hsa041221.00934298
47ABC transporters_Homo sapiens_hsa020101.00330602
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98529452
49Phototransduction_Homo sapiens_hsa047440.95915483
50Arginine and proline metabolism_Homo sapiens_hsa003300.95829077
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89383366
52Fatty acid metabolism_Homo sapiens_hsa012120.76075257
53Pyruvate metabolism_Homo sapiens_hsa006200.75660262
54Ether lipid metabolism_Homo sapiens_hsa005650.72762621
55Staphylococcus aureus infection_Homo sapiens_hsa051500.71009789
56Metabolic pathways_Homo sapiens_hsa011000.60792983
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56826578
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56379086
59Vitamin B6 metabolism_Homo sapiens_hsa007500.54334338
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53985582
61Glycerolipid metabolism_Homo sapiens_hsa005610.53771075
62Vitamin digestion and absorption_Homo sapiens_hsa049770.51159195
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47662034
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47308645
65Lysine degradation_Homo sapiens_hsa003100.42406407
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38813792
67Serotonergic synapse_Homo sapiens_hsa047260.38739736
68Oxidative phosphorylation_Homo sapiens_hsa001900.34379718
69Steroid biosynthesis_Homo sapiens_hsa001000.33948977
70Mineral absorption_Homo sapiens_hsa049780.33517337
71Nicotine addiction_Homo sapiens_hsa050330.33124465
72Systemic lupus erythematosus_Homo sapiens_hsa053220.32533469
73Biosynthesis of amino acids_Homo sapiens_hsa012300.29997047
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29375478
75Ovarian steroidogenesis_Homo sapiens_hsa049130.29004787
76Carbon metabolism_Homo sapiens_hsa012000.27837548
77Fatty acid elongation_Homo sapiens_hsa000620.27697983
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24174517
79Glutathione metabolism_Homo sapiens_hsa004800.23490219
80Protein export_Homo sapiens_hsa030600.22690645
81Fatty acid biosynthesis_Homo sapiens_hsa000610.22038563
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.20962326
83Olfactory transduction_Homo sapiens_hsa047400.20815232
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.19910652
85Parkinsons disease_Homo sapiens_hsa050120.15536764
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.14598421
87Taste transduction_Homo sapiens_hsa047420.13731818
88RNA polymerase_Homo sapiens_hsa030200.13184940
89Insulin secretion_Homo sapiens_hsa049110.12023486
90Morphine addiction_Homo sapiens_hsa050320.09534418
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.08707776
92GABAergic synapse_Homo sapiens_hsa047270.06307132
93Homologous recombination_Homo sapiens_hsa034400.05111461
94Regulation of autophagy_Homo sapiens_hsa041400.04546737
95Basal transcription factors_Homo sapiens_hsa030220.01466984
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.00640890
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.00243694
98Glutamatergic synapse_Homo sapiens_hsa04724-0.0054252
99Insulin resistance_Homo sapiens_hsa04931-0.0032914
100Asthma_Homo sapiens_hsa05310-0.0003204

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