CCL17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adhesion of symbiont to host cell (GO:0044650)8.95126986
2virion attachment to host cell (GO:0019062)8.95126986
3cellular extravasation (GO:0045123)8.16585474
4adhesion of symbiont to host (GO:0044406)7.84844313
5regulation of activation of Janus kinase activity (GO:0010533)7.08317177
6long-chain fatty acid biosynthetic process (GO:0042759)6.11476504
7wound healing, spreading of epidermal cells (GO:0035313)6.00876384
8negative regulation of inflammatory response to antigenic stimulus (GO:0002862)5.81622926
9activated T cell proliferation (GO:0050798)5.72244083
10T-helper 1 type immune response (GO:0042088)5.64988279
11lipoxygenase pathway (GO:0019372)5.50733650
12regulation of T-helper 1 cell differentiation (GO:0045625)5.49116202
13positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)5.31593387
14regulation of apoptotic cell clearance (GO:2000425)5.31169925
15neutrophil activation involved in immune response (GO:0002283)5.27020118
16negative thymic T cell selection (GO:0045060)5.20617861
17positive regulation of T-helper cell differentiation (GO:0045624)5.14710840
18regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)5.09551138
19pinocytosis (GO:0006907)4.84493018
20positive regulation of alpha-beta T cell proliferation (GO:0046641)4.79472458
21positive regulation of gamma-delta T cell activation (GO:0046645)4.79407967
22negative T cell selection (GO:0043383)4.79247751
23regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.75898834
24regulation of memory T cell differentiation (GO:0043380)4.75581201
25mannose metabolic process (GO:0006013)4.73510662
26positive regulation of interleukin-12 production (GO:0032735)4.65349496
27positive regulation of type 2 immune response (GO:0002830)4.58666065
28negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.58092694
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.57735999
30negative regulation of interleukin-17 production (GO:0032700)4.55907592
31eosinophil chemotaxis (GO:0048245)4.50764315
32positive regulation of natural killer cell differentiation (GO:0032825)4.47727789
33positive regulation of B cell differentiation (GO:0045579)4.45806694
34glycosphingolipid catabolic process (GO:0046479)4.45299023
35positive regulation of mast cell activation (GO:0033005)4.44747488
36apoptotic cell clearance (GO:0043277)4.43686059
37leukocyte migration involved in inflammatory response (GO:0002523)4.40249299
38positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.39924288
39regulation of T-helper 2 cell differentiation (GO:0045628)4.38245252
40positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.35149026
41wound healing, spreading of cells (GO:0044319)4.33772077
42granulocyte activation (GO:0036230)4.33348154
43positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.29040507
44regulation of T-helper cell differentiation (GO:0045622)4.27453642
45positive regulation of monocyte chemotaxis (GO:0090026)4.23166143
46regulation of alpha-beta T cell proliferation (GO:0046640)4.20609683
47natural killer cell mediated cytotoxicity (GO:0042267)4.19915496
48natural killer cell mediated immunity (GO:0002228)4.19915496
49positive regulation of interferon-alpha production (GO:0032727)4.16475013
50neutrophil activation (GO:0042119)4.16403306
51defense response to protozoan (GO:0042832)4.10792339
52response to peptidoglycan (GO:0032494)4.04416775
53hydrogen peroxide biosynthetic process (GO:0050665)4.04017813
54regulation of immunoglobulin secretion (GO:0051023)4.00642329
55glycolipid catabolic process (GO:0019377)3.99748416
56myeloid dendritic cell differentiation (GO:0043011)3.99268907
57eosinophil migration (GO:0072677)3.97804023
58respiratory burst (GO:0045730)3.89235615
59regulation of interferon-gamma biosynthetic process (GO:0045072)3.88636102
60negative regulation of adaptive immune response (GO:0002820)3.88363111
61positive regulation of interleukin-17 production (GO:0032740)3.88191569
62regulation of interferon-alpha production (GO:0032647)3.88028157
63immunoglobulin mediated immune response (GO:0016064)3.85272009
64homeostasis of number of cells within a tissue (GO:0048873)3.85255062
65positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.83296263
66lipopolysaccharide-mediated signaling pathway (GO:0031663)3.79808474
67regulation of interleukin-2 biosynthetic process (GO:0045076)3.79292333
68positive regulation of activated T cell proliferation (GO:0042104)3.79044894
69natural killer cell differentiation (GO:0001779)3.76420321
70regulation of T-helper 1 type immune response (GO:0002825)3.74768576
71monocyte chemotaxis (GO:0002548)3.72231766
72phosphatidylethanolamine biosynthetic process (GO:0006646)3.71303971
73regulation of transforming growth factor beta1 production (GO:0032908)3.70522967
74positive regulation of cellular amide metabolic process (GO:0034250)3.69554664
75chaperone mediated protein folding requiring cofactor (GO:0051085)3.68428816
76regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.68153477
77regulation of mononuclear cell migration (GO:0071675)3.66686817
78modulation by virus of host morphology or physiology (GO:0019048)3.65219986
79type I interferon signaling pathway (GO:0060337)3.65065002
80cellular response to type I interferon (GO:0071357)3.65065002
81regulation of RIG-I signaling pathway (GO:0039535)3.64103126
82myeloid dendritic cell activation (GO:0001773)3.63329870
83regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.61436471
84regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.61033843
85positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.59450448
86response to type I interferon (GO:0034340)3.58639878
87superoxide anion generation (GO:0042554)3.58150294
88positive regulation of T-helper 1 type immune response (GO:0002827)3.56590762
89reactive oxygen species biosynthetic process (GO:1903409)3.56505648
90ceramide catabolic process (GO:0046514)3.56104032
91positive regulation of mast cell activation involved in immune response (GO:0033008)3.53419880
92positive regulation of mast cell degranulation (GO:0043306)3.53419880
93antigen processing and presentation of endogenous antigen (GO:0019883)3.52820889
94regulation of interleukin-12 production (GO:0032655)3.51404653
95cellular response to interferon-beta (GO:0035458)3.50743332
96positive regulation of interleukin-2 production (GO:0032743)3.50527262
97cellular response to zinc ion (GO:0071294)3.50079000
98regulation of mast cell activation (GO:0033003)3.49011757
99positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.45844112
100positive thymic T cell selection (GO:0045059)3.43775543
101positive regulation of interleukin-10 production (GO:0032733)3.43457631
102phosphatidylethanolamine metabolic process (GO:0046337)3.40374642
103B cell mediated immunity (GO:0019724)3.38895784
104thymic T cell selection (GO:0045061)3.38450313
105response to protozoan (GO:0001562)3.37930126
106positive regulation of macrophage cytokine production (GO:0060907)3.37699871
107regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.36111637
108positive regulation of immune response to tumor cell (GO:0002839)3.35881256
109regulation of immune response to tumor cell (GO:0002837)3.35881256
110regulation of response to tumor cell (GO:0002834)3.35881256
111positive regulation of response to tumor cell (GO:0002836)3.35881256
112regulation of interleukin-17 production (GO:0032660)3.35392729
113regulation of hypersensitivity (GO:0002883)3.30800379
114regulation of interleukin-12 biosynthetic process (GO:0045075)3.30651727
115positive regulation of response to biotic stimulus (GO:0002833)3.27530897
116natural killer cell activation (GO:0030101)3.26328486
117response to muramyl dipeptide (GO:0032495)3.25603300
118regulation of gamma-delta T cell differentiation (GO:0045586)3.25369829
119interferon-gamma-mediated signaling pathway (GO:0060333)3.24667033
120receptor guanylyl cyclase signaling pathway (GO:0007168)3.24454643
121regulation of dendritic cell antigen processing and presentation (GO:0002604)3.24320989
122nerve growth factor signaling pathway (GO:0038180)3.23740288
123negative regulation of type 2 immune response (GO:0002829)3.23491566
124regulation of chronic inflammatory response (GO:0002676)3.22995942
125negative regulation of viral genome replication (GO:0045071)3.21609996
126T-helper cell differentiation (GO:0042093)3.21411994
127CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.21411994
128regulation of gamma-delta T cell activation (GO:0046643)3.20413796
129regulation of type 2 immune response (GO:0002828)3.18141604
130leukocyte cell-cell adhesion (GO:0007159)3.17733466
131signal peptide processing (GO:0006465)3.16563142
132regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.14482131
133positive regulation of antigen processing and presentation (GO:0002579)3.12550804
134T cell selection (GO:0045058)3.12393961
135positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.12333200
136positive regulation of chemokine secretion (GO:0090197)3.12328539
137T cell costimulation (GO:0031295)3.11486887
138positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.11036185
139leukocyte mediated cytotoxicity (GO:0001909)3.10979566
140positive regulation of T cell cytokine production (GO:0002726)3.09184325
141regulation of monocyte chemotaxis (GO:0090025)3.08643956
142regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.08197036
143negative regulation of growth of symbiont in host (GO:0044130)3.07425666
144negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.07425666
145modulation of growth of symbiont involved in interaction with host (GO:0044144)3.07425666
146regulation of growth of symbiont in host (GO:0044126)3.07425666
147positive regulation of chemokine biosynthetic process (GO:0045080)3.06701423
148lymphocyte costimulation (GO:0031294)3.06645426
149dendritic cell differentiation (GO:0097028)3.05916648
150cellular response to interferon-alpha (GO:0035457)3.05607783
151positive regulation of tissue remodeling (GO:0034105)3.04395337
152positive regulation of T cell proliferation (GO:0042102)3.03725420
153germinal center formation (GO:0002467)3.03464934
154regulation of mast cell degranulation (GO:0043304)3.03109314
155regulation of inflammatory response to antigenic stimulus (GO:0002861)3.02999628
156negative regulation of T cell mediated immunity (GO:0002710)3.01571123
157regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.99393729
158cellular response to exogenous dsRNA (GO:0071360)2.99290983
159positive regulation of isotype switching (GO:0045830)2.98716289
160production of molecular mediator involved in inflammatory response (GO:0002532)2.98419191
161intracellular pH reduction (GO:0051452)2.98401325
162macrophage differentiation (GO:0030225)2.96232152
163positive regulation of neutrophil chemotaxis (GO:0090023)2.92525391
164positive regulation of neutrophil migration (GO:1902624)2.92525391
165membrane lipid catabolic process (GO:0046466)2.91333303
166positive regulation of bone remodeling (GO:0046852)2.90611084
167positive regulation of bone resorption (GO:0045780)2.90611084
168detection of bacterium (GO:0016045)2.89646577
169protein localization to endosome (GO:0036010)2.85261996
170pH reduction (GO:0045851)2.82593687
171modification by symbiont of host morphology or physiology (GO:0044003)2.82300864

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human8.09957581
2IRF8_21731497_ChIP-ChIP_J774_Mouse7.82591333
3BP1_19119308_ChIP-ChIP_Hs578T_Human6.10095608
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.32383455
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.31847399
6IRF8_27001747_Chip-Seq_BMDM_Mouse4.22024050
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.79619242
8* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.72247951
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.57742667
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.45265379
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.31112269
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.05965014
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.97701726
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.94007355
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.90031434
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.82439464
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.55410443
18GATA1_22025678_ChIP-Seq_K562_Human2.25622887
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.19580798
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.00339493
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.97428278
22VDR_21846776_ChIP-Seq_THP-1_Human1.96773287
23VDR_24787735_ChIP-Seq_THP-1_Human1.84141451
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.83105162
25MYC_22102868_ChIP-Seq_BL_Human1.75762693
26SPI1_23547873_ChIP-Seq_NB4_Human1.74535721
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.66103277
28CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.64772337
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.62071722
30PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.59284546
31TP63_17297297_ChIP-ChIP_HaCaT_Human1.58450854
32GATA1_19941826_ChIP-Seq_K562_Human1.56659245
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.55485794
34CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.54077043
35RUNX_20019798_ChIP-Seq_JUKART_Human1.53540481
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.50311376
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.49452917
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47196925
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.46791816
40PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46407121
41MYB_26560356_Chip-Seq_TH2_Human1.46318064
42PU_27001747_Chip-Seq_BMDM_Mouse1.43601142
43LXR_22292898_ChIP-Seq_THP-1_Human1.42565258
44* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.42134022
45* GATA1_19941827_ChIP-Seq_MEL_Mouse1.40822990
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.40802792
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38690713
48UTX_26944678_Chip-Seq_JUKART_Human1.35547968
49SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34817498
50TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32951137
51CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30659627
52GATA3_26560356_Chip-Seq_TH2_Human1.30062757
53PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29066546
54NRF2_20460467_ChIP-Seq_MEFs_Mouse1.29043197
55NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.29043197
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28391452
57MAF_26560356_Chip-Seq_TH1_Human1.25426913
58ELF1_20517297_ChIP-Seq_JURKAT_Human1.21665275
59VDR_24763502_ChIP-Seq_THP-1_Human1.20683339
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20162093
61FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.19577513
62* GATA3_27048872_Chip-Seq_THYMUS_Human1.19393285
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.18168271
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17687832
65RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.12455810
66TFEB_21752829_ChIP-Seq_HELA_Human1.11431765
67MYB_26560356_Chip-Seq_TH1_Human1.07977631
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.07104846
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04055005
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03836004
71SPI1_23127762_ChIP-Seq_K562_Human1.02568429
72GATA2_19941826_ChIP-Seq_K562_Human1.02483157
73SPI1_20517297_ChIP-Seq_HL60_Human1.01406049
74RUNX1_22412390_ChIP-Seq_EML_Mouse1.01027709
75SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00786995
76RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98900299
77ELK3_25401928_ChIP-Seq_HUVEC_Human0.98824797
78KDM2B_26808549_Chip-Seq_DND41_Human0.97442348
79KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97178863
80EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94817223
81CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94773507
82TCF7_22412390_ChIP-Seq_EML_Mouse0.94556336
83EGR1_19032775_ChIP-ChIP_M12_Human0.94299185
84GATA2_21666600_ChIP-Seq_HMVEC_Human0.93851935
85PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93403280
86TRIM28_21343339_ChIP-Seq_HEK293_Human0.93016695
87GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92517953
88TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90815702
89NCOR1_26117541_ChIP-Seq_K562_Human0.89737409
90* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.89292846
91CIITA_25753668_ChIP-Seq_RAJI_Human0.87563017
92GATA1_19941827_ChIP-Seq_MEL86_Mouse0.86668338
93PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.86225600
94* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.86212364
95ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.85873626
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.85615791
97SOX2_20726797_ChIP-Seq_SW620_Human0.85035588
98CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.84312128
99CTCF_27219007_Chip-Seq_ERYTHROID_Human0.83444439
100GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82859257
101SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81254973
102KDM2B_26808549_Chip-Seq_K562_Human0.80476768
103MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.80150023
104BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80134363
105FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79792997
106SMRT_27268052_Chip-Seq_Bcells_Human0.79405035
107SCL_19346495_ChIP-Seq_HPC-7_Human0.78841511
108GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.78771044
109LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.78523120
110RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.78415859
111GATA2_22383799_ChIP-Seq_G1ME_Mouse0.76700570
112SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.76623178
113SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.76623178
114VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.74183698
115TP53_18474530_ChIP-ChIP_U2OS_Human0.70058497
116NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.69962512
117JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.67934138
118CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.67488777
119SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.67345049
120JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.64770361
121SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.63898684
122CJUN_26792858_Chip-Seq_BT549_Human0.63520722
123* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.63453369
124ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.61603894
125PU.1_20513432_ChIP-Seq_Bcells_Mouse0.59188093
126MAF_26560356_Chip-Seq_TH2_Human0.56889130
127P63_26484246_Chip-Seq_KERATINOCYTES_Human0.55634148
128CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.52607836
129PU1_27457419_Chip-Seq_LIVER_Mouse0.52551852
130RARG_19884340_ChIP-ChIP_MEFs_Mouse0.52546982
131ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.50383579
132GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.49529782
133CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.49349868
134GATA3_21867929_ChIP-Seq_TH1_Mouse0.48835104
135CMYC_18555785_Chip-Seq_ESCs_Mouse0.47347434
136PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.47300657
137TP63_23658742_ChIP-Seq_EP156T_Human0.46814629

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.82460134
2MP0009785_altered_susceptibility_to4.92013257
3* MP0002148_abnormal_hypersensitivity_rea4.68930342
4MP0003436_decreased_susceptibility_to4.07375464
5MP0001958_emphysema4.03152314
6MP0000685_abnormal_immune_system3.98604301
7MP0008004_abnormal_stomach_pH3.77621445
8MP0005000_abnormal_immune_tolerance3.52147546
9* MP0005671_abnormal_response_to3.42565924
10MP0003279_aneurysm3.42216646
11MP0005025_abnormal_response_to3.40096486
12MP0001790_abnormal_immune_system3.21666922
13MP0005387_immune_system_phenotype3.21666922
14MP0002419_abnormal_innate_immunity3.11284839
15MP0006082_CNS_inflammation2.89786718
16MP0003303_peritoneal_inflammation2.84375306
17MP0002452_abnormal_antigen_presenting2.70767940
18MP0002723_abnormal_immune_serum2.68373361
19MP0004510_myositis2.66922251
20MP0003724_increased_susceptibility_to2.55775204
21MP0001800_abnormal_humoral_immune2.46344615
22MP0009764_decreased_sensitivity_to2.41384189
23MP0002006_tumorigenesis2.36744923
24MP0001819_abnormal_immune_cell2.34625788
25MP0001853_heart_inflammation2.34623329
26MP0002420_abnormal_adaptive_immunity2.25871108
27MP0005647_abnormal_sex_gland2.19801446
28MP0001727_abnormal_embryo_implantation2.18437032
29MP0000015_abnormal_ear_pigmentation2.07550821
30MP0003705_abnormal_hypodermis_morpholog2.07158804
31MP0005451_abnormal_body_composition2.04383655
32MP0003448_altered_tumor_morphology1.97312499
33MP0001845_abnormal_inflammatory_respons1.90005717
34MP0002405_respiratory_system_inflammati1.84397050
35MP0001533_abnormal_skeleton_physiology1.77424095
36MP0003300_gastrointestinal_ulcer1.77316371
37MP0010155_abnormal_intestine_physiology1.73605571
38MP0005174_abnormal_tail_pigmentation1.69712914
39MP0008469_abnormal_protein_level1.69272243
40MP0004084_abnormal_cardiac_muscle1.69202683
41MP0002166_altered_tumor_susceptibility1.66388939
42MP0002138_abnormal_hepatobiliary_system1.66052256
43MP0000716_abnormal_immune_system1.64995800
44MP0004947_skin_inflammation1.64862826
45MP0005310_abnormal_salivary_gland1.62287177
46MP0002971_abnormal_brown_adipose1.62133807
47MP0009115_abnormal_fat_cell1.62118480
48MP0003186_abnormal_redox_activity1.54989832
49MP0005464_abnormal_platelet_physiology1.54277133
50MP0001348_abnormal_lacrimal_gland1.54098971
51MP0009333_abnormal_splenocyte_physiolog1.51413364
52MP0002398_abnormal_bone_marrow1.50148117
53MP0002163_abnormal_gland_morphology1.49336397
54MP0003075_altered_response_to1.49054619
55MP0005670_abnormal_white_adipose1.48826009
56MP0000858_altered_metastatic_potential1.44431795
57MP0005397_hematopoietic_system_phenotyp1.31787113
58MP0001545_abnormal_hematopoietic_system1.31787113
59MP0001849_ear_inflammation1.30127209
60MP0000343_altered_response_to1.29287369
61MP0001986_abnormal_taste_sensitivity1.26685677
62MP0010386_abnormal_urinary_bladder1.23528832
63MP0002429_abnormal_blood_cell1.22732704
64MP0002998_abnormal_bone_remodeling1.20512878
65MP0010234_abnormal_vibrissa_follicle1.15265872
66MP0008874_decreased_physiological_sensi1.13524534
67MP0005166_decreased_susceptibility_to1.13060651
68MP0005076_abnormal_cell_differentiation1.09899387
69MP0009763_increased_sensitivity_to1.08594340
70MP0001346_abnormal_lacrimal_gland1.05702424
71MP0005058_abnormal_lysosome_morphology1.04839831
72MP0002722_abnormal_immune_system1.00185674
73MP0000689_abnormal_spleen_morphology0.99531810
74MP0002254_reproductive_system_inflammat0.96126435
75MP0005167_abnormal_blood-brain_barrier0.96020009
76MP0001881_abnormal_mammary_gland0.91357157
77MP0002295_abnormal_pulmonary_circulatio0.90310736
78MP0000639_abnormal_adrenal_gland0.88780416
79MP0004264_abnormal_extraembryonic_tissu0.87683313
80MP0003091_abnormal_cell_migration0.87525820
81MP0004782_abnormal_surfactant_physiolog0.86933896
82MP0005164_abnormal_response_to0.84971892
83MP0004742_abnormal_vestibular_system0.82993427
84MP0003453_abnormal_keratinocyte_physiol0.80720826
85MP0005390_skeleton_phenotype0.79524575
86MP0000569_abnormal_digit_pigmentation0.79065698
87MP0010329_abnormal_lipoprotein_level0.78129916
88MP0004036_abnormal_muscle_relaxation0.78018669
89MP0005334_abnormal_fat_pad0.77901622
90MP0003763_abnormal_thymus_physiology0.76922142
91MP0002133_abnormal_respiratory_system0.76573765
92MP0005388_respiratory_system_phenotype0.76573765
93MP0008057_abnormal_DNA_replication0.75505449
94MP0003183_abnormal_peptide_metabolism0.74889299
95MP0003806_abnormal_nucleotide_metabolis0.74711395
96MP0006138_congestive_heart_failure0.74456541
97MP0000627_abnormal_mammary_gland0.73239121
98MP0005408_hypopigmentation0.72278878
99MP0002876_abnormal_thyroid_physiology0.71894727
100MP0003690_abnormal_glial_cell0.70104204
101MP0003828_pulmonary_edema0.69331577
102MP0002075_abnormal_coat/hair_pigmentati0.69261661
103MP0005379_endocrine/exocrine_gland_phen0.69120504
104MP0000249_abnormal_blood_vessel0.67439567
105MP0008260_abnormal_autophagy0.66982048
106MP0009765_abnormal_xenobiotic_induced0.66432695
107MP0003566_abnormal_cell_adhesion0.64668888
108MP0002933_joint_inflammation0.63734581
109MP0010307_abnormal_tumor_latency0.63132064
110MP0000371_diluted_coat_color0.62442689
111MP0000372_irregular_coat_pigmentation0.61760955
112MP0002693_abnormal_pancreas_physiology0.61281115
113MP0008875_abnormal_xenobiotic_pharmacok0.60909466
114MP0002277_abnormal_respiratory_mucosa0.60317197
115MP0002136_abnormal_kidney_physiology0.60097191
116MP0003172_abnormal_lysosome_physiology0.59690436
117MP0002970_abnormal_white_adipose0.58490168
118MP0004185_abnormal_adipocyte_glucose0.58378558
119MP0005319_abnormal_enzyme/_coenzyme0.57619445
120MP0005584_abnormal_enzyme/coenzyme_acti0.57254803
121MP0003634_abnormal_glial_cell0.57243050
122MP0000604_amyloidosis0.56156503
123MP0005171_absent_coat_pigmentation0.55230570
124MP0003866_abnormal_defecation0.55103934
125MP0003646_muscle_fatigue0.53793102
126MP0003195_calcinosis0.52226872
127MP0002877_abnormal_melanocyte_morpholog0.52030778
128MP0005535_abnormal_body_temperature0.51803156
129MP0003656_abnormal_erythrocyte_physiolo0.51477742
130MP0004883_abnormal_blood_vessel0.50650255
131MP0001851_eye_inflammation0.49498285
132MP0002332_abnormal_exercise_endurance0.49205411
133MP0004808_abnormal_hematopoietic_stem0.48747537
134MP0003191_abnormal_cellular_cholesterol0.47904646
135MP0009278_abnormal_bone_marrow0.47441572
136MP0000920_abnormal_myelination0.46651372
137MP0003941_abnormal_skin_development0.46239257

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)7.34432048
2Recurrent abscess formation (HP:0002722)6.66696642
3Increased IgM level (HP:0003496)6.62716888
4Recurrent bacterial skin infections (HP:0005406)6.53474858
5Gastrointestinal infarctions (HP:0005244)6.40831593
6Recurrent gram-negative bacterial infections (HP:0005420)6.38294695
7Mediastinal lymphadenopathy (HP:0100721)5.85254289
8Protuberant abdomen (HP:0001538)5.62677670
9Autoimmune thrombocytopenia (HP:0001973)4.89351761
10Elevated erythrocyte sedimentation rate (HP:0003565)4.89262432
11Abnormality of macrophages (HP:0004311)4.85131089
12Vasculitis (HP:0002633)4.55849467
13Basal ganglia calcification (HP:0002135)4.52992188
14Steatorrhea (HP:0002570)4.39285147
15Stomatitis (HP:0010280)4.19133096
16Recurrent skin infections (HP:0001581)4.06769042
17Hypercholesterolemia (HP:0003124)4.06689428
18Recurrent fungal infections (HP:0002841)3.98455302
19Increased cerebral lipofuscin (HP:0011813)3.95159530
20Systemic lupus erythematosus (HP:0002725)3.94735400
21Gingivitis (HP:0000230)3.87508379
22Hypergammaglobulinemia (HP:0010702)3.79809995
23Increased neuronal autofluorescent lipopigment (HP:0002074)3.74382935
24Upper motor neuron abnormality (HP:0002127)3.58804080
25Obstructive lung disease (HP:0006536)3.55437559
26Chronic obstructive pulmonary disease (HP:0006510)3.55437559
27Polygenic inheritance (HP:0010982)3.50262657
28Dysostosis multiplex (HP:0000943)3.40790461
29Myositis (HP:0100614)3.40760527
30Optic neuritis (HP:0100653)3.39361546
31Retrobulbar optic neuritis (HP:0100654)3.39361546
32Recurrent viral infections (HP:0004429)3.38925672
33Porencephaly (HP:0002132)3.28507253
34Orchitis (HP:0100796)3.25492367
35Multiple lipomas (HP:0001012)3.25346603
36Interstitial pulmonary disease (HP:0006530)3.23979620
37Tetraparesis (HP:0002273)3.22164885
38Vacuolated lymphocytes (HP:0001922)3.17661208
39Loss of speech (HP:0002371)3.17427018
40Spontaneous hematomas (HP:0007420)3.14884236
41Poor head control (HP:0002421)3.14827801
42Fat malabsorption (HP:0002630)3.13644555
43Amaurosis fugax (HP:0100576)3.07731079
44Hemoptysis (HP:0002105)3.04912584
45Cellulitis (HP:0100658)3.02339655
46Pulmonary infiltrates (HP:0002113)2.97648931
47Abdominal distention (HP:0003270)2.91120434
48Chronic mucocutaneous candidiasis (HP:0002728)2.90888443
49Recurrent cutaneous fungal infections (HP:0011370)2.90888443
50Axonal loss (HP:0003447)2.90403064
51Segmental peripheral demyelination/remyelination (HP:0003481)2.88800809
52Mutism (HP:0002300)2.88147785
53Recurrent pneumonia (HP:0006532)2.86510365
54Urticaria (HP:0001025)2.83717451
55Flat cornea (HP:0007720)2.82916166
56Chest pain (HP:0100749)2.82543978
57Gingival bleeding (HP:0000225)2.73801675
58Thoracic kyphosis (HP:0002942)2.73763340
59Gangrene (HP:0100758)2.70713881
60Colitis (HP:0002583)2.70687488
61Cortical dysplasia (HP:0002539)2.69090817
62Arterial thrombosis (HP:0004420)2.69043554
63IgA deficiency (HP:0002720)2.67769754
64Cheilitis (HP:0100825)2.67250622
65Autoimmune hemolytic anemia (HP:0001890)2.64403750
66Peritonitis (HP:0002586)2.64171146
67Scanning speech (HP:0002168)2.63384740
68Hypertensive crisis (HP:0100735)2.59482849
69Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.58214138
70Thick nail (HP:0001805)2.58004911
71Periodontitis (HP:0000704)2.57788587
72Leukocytosis (HP:0001974)2.57113608
73Meningitis (HP:0001287)2.56373383
74Recurrent lower respiratory tract infections (HP:0002783)2.55019491
75Abnormality of T cell number (HP:0011839)2.52534137
76Myocardial infarction (HP:0001658)2.48461430
77Anorexia (HP:0002039)2.47118615
78Chronic otitis media (HP:0000389)2.45696456
79Abnormality of glycolipid metabolism (HP:0010969)2.45602976
80Abnormality of liposaccharide metabolism (HP:0010968)2.45602976
81Abnormality of glycosphingolipid metabolism (HP:0004343)2.45602976
82Distal lower limb muscle weakness (HP:0009053)2.44898731
83Pustule (HP:0200039)2.38044296
84Inflammation of the large intestine (HP:0002037)2.37987701
85Petechiae (HP:0000967)2.37513318
86Joint swelling (HP:0001386)2.36643375
87Arthralgia (HP:0002829)2.35660012
88Thin bony cortex (HP:0002753)2.33531845
89Purpura (HP:0000979)2.31733689
90Gastrointestinal inflammation (HP:0004386)2.30447249
91Esophageal varix (HP:0002040)2.30004483
92Abnormality of the lumbar spine (HP:0100712)2.29385865
93Pulmonary hypertension (HP:0002092)2.28321501
94Panhypogammaglobulinemia (HP:0003139)2.27517653
95Albinism (HP:0001022)2.25681171
96Glomerulonephritis (HP:0000099)2.20773142
97Peripheral hypomyelination (HP:0007182)2.20259800
98Adactyly (HP:0009776)2.18903021
99Spondylolisthesis (HP:0003302)2.16868651
100Cleft eyelid (HP:0000625)2.14906637
101Agnosia (HP:0010524)2.14710239
102Abnormality of the pericardium (HP:0001697)2.14516695
103Cerebral ischemia (HP:0002637)2.13471483
104Thrombocytosis (HP:0001894)2.13220875
105Abnormality of the basal ganglia (HP:0002134)2.12064685
106Abnormal delayed hypersensitivity skin test (HP:0002963)2.11844948
107Gastrointestinal stroma tumor (HP:0100723)2.10569106
108Osteomyelitis (HP:0002754)2.10353026
109Parakeratosis (HP:0001036)2.09270391
110Apathy (HP:0000741)2.09224026
111Mucosal telangiectasiae (HP:0100579)2.09158421
112Eosinophilia (HP:0001880)2.09134015
113Diminished motivation (HP:0000745)2.09019036
114Premature loss of primary teeth (HP:0006323)2.08908192
115Nephritis (HP:0000123)2.08600651
116Viral hepatitis (HP:0006562)2.08020077
117Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.07958747
118Progressive visual loss (HP:0000529)2.07878577
119IgG deficiency (HP:0004315)2.07580697
120Prostate neoplasm (HP:0100787)2.05959517
121Abnormality of polysaccharide metabolism (HP:0011012)2.04989354
122Abnormality of glycosaminoglycan metabolism (HP:0004371)2.04989354
123Abnormality of mucopolysaccharide metabolism (HP:0011020)2.04989354
124Flat occiput (HP:0005469)2.03400431
125Abnormality of cells of the lymphoid lineage (HP:0012140)2.01443708
126Disinhibition (HP:0000734)2.00995354
127Mucopolysacchariduria (HP:0008155)2.00461210
128Urinary glycosaminoglycan excretion (HP:0003541)2.00461210
129Vertebral compression fractures (HP:0002953)2.00398429
130Abnormality of the periventricular white matter (HP:0002518)1.99281716
131Xerostomia (HP:0000217)1.99262323
132Agammaglobulinemia (HP:0004432)1.98531917
133Sepsis (HP:0100806)1.98313996
134Prolonged neonatal jaundice (HP:0006579)1.97014014
135Recurrent bronchitis (HP:0002837)1.95613764
136Ventricular fibrillation (HP:0001663)1.95579659
137Hematochezia (HP:0002573)1.95310017
138Skin ulcer (HP:0200042)1.94970102
139Lower limb hyperreflexia (HP:0002395)1.94246213
140T lymphocytopenia (HP:0005403)1.93659704
141Abnormality of T cells (HP:0002843)1.93047905
142Amyloidosis (HP:0011034)1.91058174
143Asymmetric septal hypertrophy (HP:0001670)1.90902733
144Hepatosplenomegaly (HP:0001433)1.90640986
145Bone pain (HP:0002653)1.90389917
146Abnormality of T cell physiology (HP:0011840)1.89150014
147Exertional dyspnea (HP:0002875)1.88887362
148Abnormality of the thoracic spine (HP:0100711)1.87949460
149Tinnitus (HP:0000360)1.87891572
150Abnormality of the pleura (HP:0002103)1.87491062
151Lymphopenia (HP:0001888)1.86734955
152Personality changes (HP:0000751)1.85584612
153Congenital hepatic fibrosis (HP:0002612)1.85288137
154Femoral bowing (HP:0002980)1.84465135
155Keratoconjunctivitis sicca (HP:0001097)1.84090271
156Supernumerary nipples (HP:0002558)1.84072814
157Neuronal loss in central nervous system (HP:0002529)1.83930156
158Abnormality of eosinophils (HP:0001879)1.83446007
159Abnormality of the peritoneum (HP:0002585)1.81342171
160Onion bulb formation (HP:0003383)1.81284314
161Restrictive lung disease (HP:0002091)1.80338297
162Acrocyanosis (HP:0001063)1.78953169
163Cardiomegaly (HP:0001640)1.78950059
164Bulbar palsy (HP:0001283)1.76555023
165Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.76530823

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.67319120
2PBK5.46267247
3RIPK44.85726304
4JAK33.63584463
5TBK13.59524896
6BLK3.20975216
7IRAK43.00216653
8IKBKB2.97686134
9TTN2.97616484
10TYK22.95953861
11MAP3K132.93677012
12PIM22.84239965
13PRPF4B2.60045933
14IKBKE2.31782001
15CDC42BPA2.05186865
16BMPR21.99923618
17CHUK1.94678722
18NEK91.92362808
19CAMK1D1.88972492
20NME21.77076309
21CAMK1G1.77014240
22ITK1.73133778
23IRAK31.69546764
24ABL21.69035851
25ARAF1.66974677
26JAK11.66973800
27PIK3CG1.61212624
28MST41.58507363
29TXK1.49961612
30CAMKK21.44170320
31STK41.41477508
32RPS6KA21.40355831
33SIK31.38668901
34BMX1.31660424
35CAMKK11.31531635
36CDK61.30921000
37ERBB31.30882835
38SYK1.27719141
39MAP4K11.19643188
40JAK21.14693351
41PIM11.07967290
42DAPK21.04909351
43MAP3K81.01210179
44SMG10.99969661
45TESK10.98649670
46CSK0.98104340
47PDPK10.98094632
48TAOK30.97292380
49MARK30.96498276
50TRPM70.95693067
51BCR0.94991784
52PDK10.92685340
53ZAP700.92373697
54KIT0.91536679
55TESK20.91424418
56MST1R0.88839847
57EIF2AK20.88680566
58BTK0.86799747
59HCK0.83950796
60RPS6KC10.83753671
61RPS6KL10.83753671
62RPS6KA40.82244677
63LYN0.82081595
64STK240.81327955
65PRKCQ0.81320843
66EPHB10.79682350
67LCK0.79667079
68SGK30.79654345
69CDK120.79184654
70EEF2K0.77565911
71FGFR30.77050210
72YES10.75532833
73MAPKAPK30.75383702
74MAP3K120.68257667
75IRAK20.67969406
76IRAK10.67399684
77RPS6KA60.67235516
78MAP3K20.66712242
79MAP3K50.65210764
80PRKCD0.64999997
81BCKDK0.63227369
82MAPK120.60829230
83ERN10.60559318
84ABL10.59792430
85SGK20.58372879
86MAPK70.57999867
87ADRBK20.57990163
88ERBB40.53202720
89MAP3K110.51846215
90MAPKAPK50.51812156
91MATK0.50926485
92SCYL20.48172580
93FGR0.47800608
94MOS0.47455968
95MAP3K60.46669306
96GRK70.45367443
97RET0.45011948
98TGFBR20.44587033
99DAPK30.43771307
100EPHA30.43330421
101FGFR40.43279228
102MAPKAPK20.41099972
103CSF1R0.40731444
104PRKACB0.40010134
105SIK20.39878226
106EGFR0.39746451
107MAP2K40.39567923
108PKN20.39364236
109FYN0.38590070
110PAK10.36019866
111MAP3K90.35075755
112PKN10.34865437
113STK30.34498707
114BMPR1B0.33922015
115KSR10.33648091
116WNK40.33582271
117KSR20.33018048
118MAP3K10.32713673
119STK390.32602456
120DAPK10.31852068
121MAPK40.29584031
122TAOK20.29272253
123RIPK10.28435686
124LRRK20.27833841
125FES0.27725060
126RPS6KB10.25721833
127WNK10.25477860
128PRKCE0.25423407
129RPS6KA10.25390733
130ROCK10.23961313
131TRIB30.23267835
132NLK0.20789816
133TEC0.20291225
134MAPK30.20009510
135RAF10.17271936
136BRAF0.16952304
137SRC0.16382268
138PLK20.16155354
139DYRK1B0.15908250
140LIMK10.13105989
141SIK10.12426783
142INSR0.11868831
143IGF1R0.11681190
144PTK2B0.10894576
145GSK3A0.10398658
146PRKACG0.10348498

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053304.98519441
2Graft-versus-host disease_Homo sapiens_hsa053324.24078244
3Type I diabetes mellitus_Homo sapiens_hsa049403.53701559
4Steroid biosynthesis_Homo sapiens_hsa001003.38470520
5Leishmaniasis_Homo sapiens_hsa051402.99841888
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.90371753
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.89567910
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.56372200
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.55510350
10Legionellosis_Homo sapiens_hsa051342.52898911
11Autoimmune thyroid disease_Homo sapiens_hsa053202.46521920
12NOD-like receptor signaling pathway_Homo sapiens_hsa046212.43240129
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.39421121
14Asthma_Homo sapiens_hsa053102.35795018
15Rheumatoid arthritis_Homo sapiens_hsa053232.30390364
16African trypanosomiasis_Homo sapiens_hsa051432.24634251
17Pertussis_Homo sapiens_hsa051332.15842318
18Measles_Homo sapiens_hsa051622.07554126
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.05856495
20Malaria_Homo sapiens_hsa051441.99053664
21TNF signaling pathway_Homo sapiens_hsa046681.91469308
22Influenza A_Homo sapiens_hsa051641.84168975
23Tuberculosis_Homo sapiens_hsa051521.81260162
24Osteoclast differentiation_Homo sapiens_hsa043801.79474849
25Viral myocarditis_Homo sapiens_hsa054161.79078710
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.71677157
27Staphylococcus aureus infection_Homo sapiens_hsa051501.68054143
28Toxoplasmosis_Homo sapiens_hsa051451.56410482
29Salmonella infection_Homo sapiens_hsa051321.54541285
30* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.49937945
31Herpes simplex infection_Homo sapiens_hsa051681.49507208
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.36202419
33* Chemokine signaling pathway_Homo sapiens_hsa040621.34243734
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.33155812
35Phagosome_Homo sapiens_hsa041451.31406869
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.25838855
37Apoptosis_Homo sapiens_hsa042101.20359894
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.19666573
39Shigellosis_Homo sapiens_hsa051311.18155664
40Linoleic acid metabolism_Homo sapiens_hsa005911.16610350
41Pentose phosphate pathway_Homo sapiens_hsa000301.15419469
42B cell receptor signaling pathway_Homo sapiens_hsa046621.14078283
43Primary immunodeficiency_Homo sapiens_hsa053401.13073392
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02875589
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01625372
46Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.96785405
47Prion diseases_Homo sapiens_hsa050200.94938316
48Antigen processing and presentation_Homo sapiens_hsa046120.93849663
49Hematopoietic cell lineage_Homo sapiens_hsa046400.92334432
50Amoebiasis_Homo sapiens_hsa051460.90230398
51Hepatitis B_Homo sapiens_hsa051610.86297015
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85497539
53Galactose metabolism_Homo sapiens_hsa000520.83695959
54Proteasome_Homo sapiens_hsa030500.80876789
55Prolactin signaling pathway_Homo sapiens_hsa049170.79873922
56Lysosome_Homo sapiens_hsa041420.76899610
57Collecting duct acid secretion_Homo sapiens_hsa049660.76072594
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75740694
59Hepatitis C_Homo sapiens_hsa051600.71736310
60Acute myeloid leukemia_Homo sapiens_hsa052210.65595131
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.64305972
62T cell receptor signaling pathway_Homo sapiens_hsa046600.59152365
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55173243
64Renal cell carcinoma_Homo sapiens_hsa052110.55006609
65Arachidonic acid metabolism_Homo sapiens_hsa005900.53177284
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.51418701
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50320951
68Epstein-Barr virus infection_Homo sapiens_hsa051690.48831130
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46740419
70Chronic myeloid leukemia_Homo sapiens_hsa052200.43631577
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39277647
72Phenylalanine metabolism_Homo sapiens_hsa003600.39191027
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38946511
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38833413
75Fructose and mannose metabolism_Homo sapiens_hsa000510.38742968
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38146557
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.36189220
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36182644
79Other glycan degradation_Homo sapiens_hsa005110.35500757
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34988139
81Renin secretion_Homo sapiens_hsa049240.33902130
82Platelet activation_Homo sapiens_hsa046110.33855186
83Vibrio cholerae infection_Homo sapiens_hsa051100.32473890
84Complement and coagulation cascades_Homo sapiens_hsa046100.31136549
85Non-small cell lung cancer_Homo sapiens_hsa052230.30453132
86Endocytosis_Homo sapiens_hsa041440.29992263
87Type II diabetes mellitus_Homo sapiens_hsa049300.29258948
88Vitamin B6 metabolism_Homo sapiens_hsa007500.28059373
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.27867123
90Pancreatic cancer_Homo sapiens_hsa052120.27247685
91Viral carcinogenesis_Homo sapiens_hsa052030.26526349
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26196476
93Rap1 signaling pathway_Homo sapiens_hsa040150.25503938
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.23536032
95HIF-1 signaling pathway_Homo sapiens_hsa040660.22978925
96Renin-angiotensin system_Homo sapiens_hsa046140.22372022
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.21039645
98Fatty acid elongation_Homo sapiens_hsa000620.20127795
99Caffeine metabolism_Homo sapiens_hsa002320.19519080
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.18652908
101HTLV-I infection_Homo sapiens_hsa051660.18497114
102Small cell lung cancer_Homo sapiens_hsa052220.17190567
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.16299498
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15565723
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.14990608
106Pentose and glucuronate interconversions_Homo sapiens_hsa000400.14512743
107VEGF signaling pathway_Homo sapiens_hsa043700.14304174
108Estrogen signaling pathway_Homo sapiens_hsa049150.13407639
109Oxytocin signaling pathway_Homo sapiens_hsa049210.13010693
110Insulin resistance_Homo sapiens_hsa049310.12885097
111GnRH signaling pathway_Homo sapiens_hsa049120.12884002
112Mineral absorption_Homo sapiens_hsa049780.12556021
113Inositol phosphate metabolism_Homo sapiens_hsa005620.12121263
114Proteoglycans in cancer_Homo sapiens_hsa052050.11734902
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.10444624
116Dorso-ventral axis formation_Homo sapiens_hsa043200.09040369
117FoxO signaling pathway_Homo sapiens_hsa040680.07913518
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.07490510
119Systemic lupus erythematosus_Homo sapiens_hsa053220.07080835
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.06785713
121ErbB signaling pathway_Homo sapiens_hsa040120.02757297
122p53 signaling pathway_Homo sapiens_hsa041150.02503557
123Adherens junction_Homo sapiens_hsa045200.02091849
124Oxidative phosphorylation_Homo sapiens_hsa001900.01496394

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