CCL18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of mononuclear cell migration (GO:0071675)5.84858384
2surfactant homeostasis (GO:0043129)5.59391650
3immunoglobulin mediated immune response (GO:0016064)5.52247341
4regulation of macrophage chemotaxis (GO:0010758)5.35662626
5complement activation, classical pathway (GO:0006958)5.23538067
6eosinophil chemotaxis (GO:0048245)4.68685494
7glycosphingolipid catabolic process (GO:0046479)4.68650086
8regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.64440143
9complement activation (GO:0006956)4.63442427
10regulation of cholesterol storage (GO:0010885)4.34465761
11interferon-gamma-mediated signaling pathway (GO:0060333)4.27860941
12glycolipid catabolic process (GO:0019377)4.24932790
13eosinophil migration (GO:0072677)4.21452084
14cellular response to thyroid hormone stimulus (GO:0097067)4.14504123
15chemical homeostasis within a tissue (GO:0048875)4.13052225
16regulation of hypersensitivity (GO:0002883)4.06797765
17B cell mediated immunity (GO:0019724)4.04366842
18regulation of antigen processing and presentation (GO:0002577)3.97551071
19peptide catabolic process (GO:0043171)3.91467341
20oligosaccharide catabolic process (GO:0009313)3.89434419
21positive regulation of antigen processing and presentation (GO:0002579)3.86473393
22ceramide catabolic process (GO:0046514)3.75136481
23regulation of dendritic cell antigen processing and presentation (GO:0002604)3.70760223
24negative regulation of complement activation (GO:0045916)3.69005982
25apoptotic cell clearance (GO:0043277)3.64418585
26cellular response to interferon-gamma (GO:0071346)3.59992542
27T-helper 1 type immune response (GO:0042088)3.57417491
28positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.52146014
29neutrophil activation involved in immune response (GO:0002283)3.50139225
30response to interferon-gamma (GO:0034341)3.42800841
31phagocytosis, recognition (GO:0006910)3.42566715
32protein activation cascade (GO:0072376)3.41448916
33negative regulation of interleukin-12 production (GO:0032695)3.40515945
34detection of other organism (GO:0098543)3.39666132
35detection of bacterium (GO:0016045)3.38106406
36cellular extravasation (GO:0045123)3.37851278
37negative regulation of humoral immune response (GO:0002921)3.34704582
38positive regulation of type 2 immune response (GO:0002830)3.32303665
39positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.31075562
40keratan sulfate catabolic process (GO:0042340)3.30599474
41amino sugar catabolic process (GO:0046348)3.26972964
42phagocytosis, engulfment (GO:0006911)3.24705608
43negative regulation of protein activation cascade (GO:2000258)3.23315243
44regulation of T-helper 2 cell differentiation (GO:0045628)3.23176174
45response to thyroid hormone (GO:0097066)3.22607059
46positive regulation of monocyte chemotaxis (GO:0090026)3.19016150
47detection of external biotic stimulus (GO:0098581)3.17645080
48barbed-end actin filament capping (GO:0051016)3.09198864
49negative regulation of interleukin-2 production (GO:0032703)3.07318614
50positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.04458150
51regulation of inflammatory response to antigenic stimulus (GO:0002861)2.99622797
52sphingolipid catabolic process (GO:0030149)2.97671734
53humoral immune response (GO:0006959)2.95559614
54myeloid dendritic cell differentiation (GO:0043011)2.94675373
55regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.93508803
56positive thymic T cell selection (GO:0045059)2.92432593
57positive regulation of neutrophil migration (GO:1902624)2.92173496
58positive regulation of neutrophil chemotaxis (GO:0090023)2.92173496
59cellular response to type I interferon (GO:0071357)2.91309343
60type I interferon signaling pathway (GO:0060337)2.91309343
61positive regulation of toll-like receptor signaling pathway (GO:0034123)2.90821716
62lipopolysaccharide-mediated signaling pathway (GO:0031663)2.90232056
63adhesion of symbiont to host cell (GO:0044650)2.89301715
64virion attachment to host cell (GO:0019062)2.89301715
65positive regulation of granulocyte chemotaxis (GO:0071624)2.86756838
66response to type I interferon (GO:0034340)2.86505912
67positive regulation of cholesterol efflux (GO:0010875)2.85702946
68antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.85634768
69membrane lipid catabolic process (GO:0046466)2.84652355
70regulation of granulocyte chemotaxis (GO:0071622)2.84477887
71negative regulation of innate immune response (GO:0045824)2.83727748
72detection of molecule of bacterial origin (GO:0032490)2.81499300
73angiogenesis involved in wound healing (GO:0060055)2.81321711
74antigen processing and presentation of endogenous antigen (GO:0019883)2.77398997
75lipoxygenase pathway (GO:0019372)2.76923896
76lymphocyte chemotaxis (GO:0048247)2.75662971
77regulation of monocyte chemotaxis (GO:0090025)2.75568184
78regulation of macrophage derived foam cell differentiation (GO:0010743)2.75428490
79macrophage chemotaxis (GO:0048246)2.74639779
80T cell costimulation (GO:0031295)2.73002560
81regulation of interleukin-2 biosynthetic process (GO:0045076)2.72444784
82regulation of cholesterol esterification (GO:0010872)2.71771099
83monocyte chemotaxis (GO:0002548)2.71053642
84negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.71029374
85detection of biotic stimulus (GO:0009595)2.69946213
86phospholipid efflux (GO:0033700)2.69911593
87regulation of T cell tolerance induction (GO:0002664)2.68759457
88lymphocyte costimulation (GO:0031294)2.68640349
89membrane invagination (GO:0010324)2.68519819
90regulation of tolerance induction (GO:0002643)2.66933778
91response to peptidoglycan (GO:0032494)2.65408190
92regulation of T-helper 1 cell differentiation (GO:0045625)2.64952620
93regulation of type 2 immune response (GO:0002828)2.64308394
94adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.62926523
95granulocyte activation (GO:0036230)2.62764246
96positive regulation of leukocyte chemotaxis (GO:0002690)2.62365393
97positive regulation of cellular amide metabolic process (GO:0034250)2.62154265
98positive regulation of T-helper cell differentiation (GO:0045624)2.61742863
99positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.61330101
100antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.59533757

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.64206524
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.21071997
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.55753798
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.70786950
5NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.56586995
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.54100992
7RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.90097889
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.86660740
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.70640005
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.64922170
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.60448248
12VDR_24787735_ChIP-Seq_THP-1_Human2.49883784
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.29030853
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.24221588
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.14089060
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.03585302
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.02777487
18STAT4_19710469_ChIP-ChIP_TH1__Mouse1.99511836
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.90113143
20STAT6_21828071_ChIP-Seq_BEAS2B_Human1.82170363
21VDR_24763502_ChIP-Seq_THP-1_Human1.79954662
22TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.69445401
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.66046569
24ESR1_21235772_ChIP-Seq_MCF-7_Human1.59863502
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.59689471
26SPI1_23127762_ChIP-Seq_K562_Human1.55965484
27EGR1_19032775_ChIP-ChIP_M12_Human1.53348819
28CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.51915768
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.51603766
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.48164694
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.46812537
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.42853355
33GATA1_22025678_ChIP-Seq_K562_Human1.41954847
34GATA2_21666600_ChIP-Seq_HMVEC_Human1.39748706
35BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.39268496
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.38479838
37PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35293246
38CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33158749
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.32952785
40LXR_22158963_ChIP-Seq_LIVER_Mouse1.32811954
41LXR_22292898_ChIP-Seq_THP-1_Human1.30513199
42PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30045861
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30013511
44ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.27420340
45SOX2_20726797_ChIP-Seq_SW620_Human1.24808460
46CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23660868
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.23084007
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.22322455
49RUNX_20019798_ChIP-Seq_JUKART_Human1.22157192
50GATA1_19941826_ChIP-Seq_K562_Human1.22018079
51SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21488063
52SPI1_23547873_ChIP-Seq_NB4_Human1.20028026
53LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19773654
54RXR_22158963_ChIP-Seq_LIVER_Mouse1.19483178
55PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15502774
56ELK3_25401928_ChIP-Seq_HUVEC_Human1.13626550
57LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12726864
58PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.09492231
59P63_26484246_Chip-Seq_KERATINOCYTES_Human1.09340272
60PU_27001747_Chip-Seq_BMDM_Mouse1.08324725
61CLOCK_20551151_ChIP-Seq_293T_Human1.08197785
62PPARA_22158963_ChIP-Seq_LIVER_Mouse1.06837296
63SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06027042
64TRIM28_21343339_ChIP-Seq_HEK293_Human1.05522218
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05511980
66GATA1_19941827_ChIP-Seq_MEL_Mouse1.04839613
67CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.04420638
68RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.04351410
69GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03170177
70CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02382164
71SCL_19346495_ChIP-Seq_HPC-7_Human1.02151954
72STAT1_20625510_ChIP-Seq_HELA_Human0.98698595
73PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95238476
74VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94859918
75SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94731281
76PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94536606
77FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.94066070
78VDR_21846776_ChIP-Seq_THP-1_Human0.92835460
79SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92480803
80E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92407756
81KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91837504
82FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.90615924
83CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89193967
84FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88907336
85ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87625219
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85340128
87SOX2_27498859_Chip-Seq_STOMACH_Mouse0.84392622
88MYB_26560356_Chip-Seq_TH2_Human0.83898917
89MAF_26560356_Chip-Seq_TH1_Human0.81462370
90GATA2_19941826_ChIP-Seq_K562_Human0.80376476
91CDX2_20551321_ChIP-Seq_CACO-2_Human0.80206415
92SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79792976
93NFIB_24661679_ChIP-Seq_LUNG_Mouse0.76409599
94BCL6_27268052_Chip-Seq_Bcells_Human0.75903270
95BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.75833506
96GATA3_27048872_Chip-Seq_THYMUS_Human0.75528798
97GATA2_22383799_ChIP-Seq_G1ME_Mouse0.74772442
98RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.74103140
99JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73587551
100NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.73147870

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009840_abnormal_foam_cell5.62541044
2MP0005058_abnormal_lysosome_morphology3.44561397
3MP0003191_abnormal_cellular_cholesterol3.42562622
4MP0001835_abnormal_antigen_presentation3.30329869
5MP0003724_increased_susceptibility_to3.13877190
6MP0000604_amyloidosis2.96872251
7MP0004782_abnormal_surfactant_physiolog2.92576481
8MP0002148_abnormal_hypersensitivity_rea2.90344051
9MP0003303_peritoneal_inflammation2.90169817
10MP0000569_abnormal_digit_pigmentation2.73093810
11MP0005387_immune_system_phenotype2.69740238
12MP0001790_abnormal_immune_system2.69740238
13MP0005671_abnormal_response_to2.69660918
14MP0006082_CNS_inflammation2.52274896
15MP0002419_abnormal_innate_immunity2.41116887
16MP0003436_decreased_susceptibility_to2.40960790
17MP0003172_abnormal_lysosome_physiology2.37860400
18MP0005025_abnormal_response_to2.35994007
19MP0009785_altered_susceptibility_to2.28970842
20MP0003300_gastrointestinal_ulcer2.14086092
21MP0002139_abnormal_hepatobiliary_system2.13508267
22MP0005000_abnormal_immune_tolerance2.12395463
23MP0002452_abnormal_antigen_presenting1.98090235
24MP0000343_altered_response_to1.90954408
25MP0001800_abnormal_humoral_immune1.83243699
26MP0002877_abnormal_melanocyte_morpholog1.81384587
27MP0005360_urolithiasis1.78358573
28MP0000685_abnormal_immune_system1.77376740
29MP0002723_abnormal_immune_serum1.76573305
30MP0005167_abnormal_blood-brain_barrier1.70936681
31MP0003329_amyloid_beta_deposits1.66544314
32MP0005257_abnormal_intraocular_pressure1.65514466
33MP0001845_abnormal_inflammatory_respons1.65161709
34MP0001533_abnormal_skeleton_physiology1.64512179
35MP0009764_decreased_sensitivity_to1.63780496
36MP0005365_abnormal_bile_salt1.63648222
37MP0003075_altered_response_to1.58137792
38MP0003448_altered_tumor_morphology1.57282583
39MP0001958_emphysema1.55308932
40MP0002405_respiratory_system_inflammati1.54595971
41MP0002420_abnormal_adaptive_immunity1.52944790
42MP0002998_abnormal_bone_remodeling1.52914811
43MP0001819_abnormal_immune_cell1.52158649
44MP0008004_abnormal_stomach_pH1.44987074
45MP0004947_skin_inflammation1.39046691
46MP0008469_abnormal_protein_level1.32898564
47MP0002166_altered_tumor_susceptibility1.30277879
48MP0010155_abnormal_intestine_physiology1.28961889
49MP0001853_heart_inflammation1.28395818
50MP0005464_abnormal_platelet_physiology1.26910321
51MP0005166_decreased_susceptibility_to1.26894783
52MP0005310_abnormal_salivary_gland1.26841156
53MP0000249_abnormal_blood_vessel1.23098087
54MP0002933_joint_inflammation1.22377703
55MP0003690_abnormal_glial_cell1.21463977
56MP0005275_abnormal_skin_tensile1.19348320
57MP0000920_abnormal_myelination1.18363419
58MP0000015_abnormal_ear_pigmentation1.15345452
59MP0003828_pulmonary_edema1.10604606
60MP0005164_abnormal_response_to1.05640085
61MP0004264_abnormal_extraembryonic_tissu1.04608991
62MP0005174_abnormal_tail_pigmentation1.03584039
63MP0000465_gastrointestinal_hemorrhage1.02922948
64MP0001542_abnormal_bone_strength1.01274159
65MP0000858_altered_metastatic_potential1.00563111
66MP0000716_abnormal_immune_system1.00289521
67MP0003806_abnormal_nucleotide_metabolis0.99807787
68MP0002277_abnormal_respiratory_mucosa0.97600920
69MP0002009_preneoplasia0.93248193
70MP0002133_abnormal_respiratory_system0.92762011
71MP0005388_respiratory_system_phenotype0.92762011
72MP0010234_abnormal_vibrissa_follicle0.92661566
73MP0003453_abnormal_keratinocyte_physiol0.92201318
74MP0000371_diluted_coat_color0.91245304
75MP0009333_abnormal_splenocyte_physiolog0.87975173
76MP0002006_tumorigenesis0.87863356
77MP0004510_myositis0.87469121
78MP0002254_reproductive_system_inflammat0.87140095
79MP0005165_increased_susceptibility_to0.83573045
80MP0005023_abnormal_wound_healing0.81444628
81MP0001851_eye_inflammation0.80863456
82MP0002090_abnormal_vision0.80537034
83MP0001756_abnormal_urination0.80004487
84MP0009763_increased_sensitivity_to0.78233046
85MP0004883_abnormal_blood_vessel0.76494078
86MP0005390_skeleton_phenotype0.74992583
87MP0002429_abnormal_blood_cell0.74297063
88MP0003091_abnormal_cell_migration0.74246252
89MP0003279_aneurysm0.74124489
90MP0004019_abnormal_vitamin_homeostasis0.74074973
91MP0002136_abnormal_kidney_physiology0.73261975
92MP0003795_abnormal_bone_structure0.71814166
93MP0005408_hypopigmentation0.71216706
94MP0000681_abnormal_thyroid_gland0.69188880
95MP0002796_impaired_skin_barrier0.67570729
96MP0002295_abnormal_pulmonary_circulatio0.65884465
97MP0009278_abnormal_bone_marrow0.63840337
98MP0008260_abnormal_autophagy0.63604947
99MP0002398_abnormal_bone_marrow0.63437015
100MP0010386_abnormal_urinary_bladder0.61961568

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)7.45396966
2Abnormality of glycosphingolipid metabolism (HP:0004343)7.45396966
3Abnormality of glycolipid metabolism (HP:0010969)7.45396966
4Glomerulonephritis (HP:0000099)5.79838580
5Complement deficiency (HP:0004431)5.21310963
6Interstitial pulmonary disease (HP:0006530)4.58777828
7Abnormality of macrophages (HP:0004311)4.41599170
8Abnormality of complement system (HP:0005339)4.37133600
9Recurrent bacterial skin infections (HP:0005406)4.03912794
10Increased cerebral lipofuscin (HP:0011813)3.91446720
11Eczematoid dermatitis (HP:0000976)3.82565188
12Prostate neoplasm (HP:0100787)3.73667051
13Recurrent abscess formation (HP:0002722)3.58404094
14Disinhibition (HP:0000734)3.55948823
15Premature loss of primary teeth (HP:0006323)3.47127103
16Nephritis (HP:0000123)3.40617988
17Axonal loss (HP:0003447)3.35301679
18Dysostosis multiplex (HP:0000943)3.32936226
19Increased neuronal autofluorescent lipopigment (HP:0002074)3.21126869
20Vacuolated lymphocytes (HP:0001922)3.18888747
21Osteolytic defects of the phalanges of the hand (HP:0009771)3.17759101
22Osteolytic defects of the hand bones (HP:0009699)3.17759101
23Loss of speech (HP:0002371)3.16778547
24Thick nail (HP:0001805)3.12795019
25Malnutrition (HP:0004395)2.93746644
26Abnormality of the prostate (HP:0008775)2.89217712
27Neurofibrillary tangles (HP:0002185)2.78824787
28Pustule (HP:0200039)2.67885538
29Recurrent gram-negative bacterial infections (HP:0005420)2.66916829
30Autoimmune thrombocytopenia (HP:0001973)2.66619202
31Nuclear cataract (HP:0100018)2.65848928
32Abnormality of mucopolysaccharide metabolism (HP:0011020)2.64648694
33Abnormality of polysaccharide metabolism (HP:0011012)2.64648694
34Abnormality of glycosaminoglycan metabolism (HP:0004371)2.64648694
35Gingivitis (HP:0000230)2.62295900
36Mutism (HP:0002300)2.61406879
37Purpura (HP:0000979)2.58548138
38Esophageal neoplasm (HP:0100751)2.53855851
39Neoplasm of head and neck (HP:0012288)2.53855851
40Mediastinal lymphadenopathy (HP:0100721)2.53694156
41Mucopolysacchariduria (HP:0008155)2.48183073
42Urinary glycosaminoglycan excretion (HP:0003541)2.48183073
43Albinism (HP:0001022)2.43324931
44Myocardial infarction (HP:0001658)2.43301366
45Apathy (HP:0000741)2.41917945
46Abnormality of the nasal mucosa (HP:0000433)2.39074988
47Pulmonary infiltrates (HP:0002113)2.38866064
48Hypergammaglobulinemia (HP:0010702)2.38719318
49Recurrent skin infections (HP:0001581)2.38244512
50Diminished motivation (HP:0000745)2.35287811
51Hemoptysis (HP:0002105)2.34806423
52Periodontitis (HP:0000704)2.17513428
53Segmental peripheral demyelination/remyelination (HP:0003481)2.16156913
54Increased serum ferritin (HP:0003281)2.11297684
55Pulmonary fibrosis (HP:0002206)2.09627564
56Obstructive lung disease (HP:0006536)2.08831626
57Chronic obstructive pulmonary disease (HP:0006510)2.08831626
58Metaphyseal irregularity (HP:0003025)2.06810104
59Spontaneous hematomas (HP:0007420)2.05063640
60Increased IgE level (HP:0003212)2.04414326
61Abnormality of the vasculature of the conjunctiva (HP:0008054)2.04409788
62Neuronal loss in central nervous system (HP:0002529)2.01523910
63Systemic lupus erythematosus (HP:0002725)10.0465184
64Cerebral inclusion bodies (HP:0100314)1.98020180
65Retinal atrophy (HP:0001105)1.97530656
66Restrictive lung disease (HP:0002091)1.94859774
67Mucosal telangiectasiae (HP:0100579)1.94329249
68Bone cyst (HP:0012062)1.90967516
69Pulmonary hypertension (HP:0002092)1.90754912
70Abnormality of iron homeostasis (HP:0011031)1.90512475
71Erythema (HP:0010783)1.89786769
72Urticaria (HP:0001025)1.85962874
73Increased CSF protein (HP:0002922)1.85687043
74Inappropriate behavior (HP:0000719)1.85186091
75Palmoplantar hyperkeratosis (HP:0000972)1.84930613
76Hematochezia (HP:0002573)1.83201192
77Peripheral demyelination (HP:0011096)1.83110552
78Dementia (HP:0000726)1.79100873
79Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.76072934
80J-shaped sella turcica (HP:0002680)1.75988546
81Vasculitis (HP:0002633)1.75784014
82Abnormality of the periventricular white matter (HP:0002518)1.75699959
83Bone pain (HP:0002653)1.74480262
84Amyloidosis (HP:0011034)1.73068751
85Conjunctival telangiectasia (HP:0000524)1.72882936
86Gangrene (HP:0100758)1.72446629
87Gastrointestinal infarctions (HP:0005244)1.70851151
88Nasal polyposis (HP:0100582)1.70843585
89Meningitis (HP:0001287)1.69463843
90Basal ganglia calcification (HP:0002135)1.68902946
91Palmar hyperkeratosis (HP:0010765)1.67552474
92Hepatosplenomegaly (HP:0001433)1.66173620
93Diaphragmatic weakness (HP:0009113)1.64751125
94Progressive neurologic deterioration (HP:0002344)1.64425575
95Osteomyelitis (HP:0002754)1.61383339
96Ocular albinism (HP:0001107)1.61349065
97Recurrent fungal infections (HP:0002841)1.61276534
98Distal lower limb muscle weakness (HP:0009053)1.61170563
99Abnormality of transition element cation homeostasis (HP:0011030)1.60636847
100Upper motor neuron abnormality (HP:0002127)1.60520225

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.93371295
2PDK23.11904678
3ERN13.07769242
4TYK23.07143121
5DMPK2.51283826
6MAP3K142.39764256
7IRAK32.33309459
8MAP4K12.31820079
9TGFBR22.30868721
10ZAP702.21430462
11TXK2.11272934
12TBK12.05335380
13BMPR21.85330317
14RIPK41.81163273
15CDC42BPA1.79035258
16JAK31.72184014
17DDR21.69244875
18GRK71.65805260
19RIPK11.59023395
20MAP3K31.57520198
21IKBKE1.57229735
22CSK1.55557297
23FGFR41.54676479
24MATK1.51362656
25KIT1.46057708
26EPHA31.45814377
27JAK11.42237038
28IKBKB1.37272742
29TRIM281.36262595
30FGR1.32015717
31PRPF4B1.29766835
32ACVR1B1.29504648
33LATS21.27937325
34CSF1R1.26678803
35MAP3K131.24167296
36CDK61.22865515
37RPS6KA21.22235529
38MAPK151.15532721
39LYN1.14616856
40MAP3K111.13400716
41SYK1.13163277
42ABL21.12977846
43JAK21.08153571
44EPHB11.06570728
45MAP3K121.04945957
46MAP3K61.01438776
47NME21.00578215
48MAP3K10.98853800
49FGFR30.97224865
50IRAK40.95838870
51FES0.95837219
52MYLK0.94826043
53RPS6KL10.92520673
54RPS6KC10.92520673
55TAOK20.87657447
56PDPK10.87444160
57MAPK70.85190375
58HCK0.82037296
59ADRBK20.80461619
60MST1R0.78869441
61MAPKAPK30.77180664
62LRRK20.76957935
63RPS6KA60.76743447
64PAK40.74949740
65ABL10.74526846
66MAP2K30.74151032
67TIE10.71992293
68LCK0.67855711
69IRAK10.66721300
70MAPK120.65335776
71CDK90.64336011
72MAPKAPK20.61296072
73FYN0.60639252
74HIPK20.58816598
75TGFBR10.58109574
76TAOK10.56100110
77FER0.52017905
78MOS0.51479012
79MAP2K60.51147590
80EPHB20.50442035
81IGF1R0.49771695
82EGFR0.49535636
83PRKD10.49217271
84PRKG20.49125282
85PDK10.48781134
86PDGFRB0.48152264
87MAP3K50.47221191
88PDGFRA0.46359945
89CHUK0.44794167
90TESK10.43851402
91MARK30.42550912
92NTRK20.41671845
93MAP2K20.40584799
94MARK20.39142611
95NEK90.38668560
96RPS6KA50.37574924
97CAMKK20.35999784
98NEK60.35907145
99PRKACG0.35491791
100INSR0.34084888

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051505.00471514
2Asthma_Homo sapiens_hsa053104.07803246
3Allograft rejection_Homo sapiens_hsa053303.77696781
4Autoimmune thyroid disease_Homo sapiens_hsa053203.44548386
5Graft-versus-host disease_Homo sapiens_hsa053323.44451374
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.11381858
7Type I diabetes mellitus_Homo sapiens_hsa049402.95876381
8Rheumatoid arthritis_Homo sapiens_hsa053232.88617725
9Leishmaniasis_Homo sapiens_hsa051402.75144360
10Lysosome_Homo sapiens_hsa041422.73288877
11Antigen processing and presentation_Homo sapiens_hsa046122.57605538
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.36123521
13Pertussis_Homo sapiens_hsa051332.35880993
14Phagosome_Homo sapiens_hsa041452.26744013
15Other glycan degradation_Homo sapiens_hsa005112.17009350
16Viral myocarditis_Homo sapiens_hsa054162.10821670
17Tuberculosis_Homo sapiens_hsa051521.93451837
18Complement and coagulation cascades_Homo sapiens_hsa046101.82806581
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.79201884
20Osteoclast differentiation_Homo sapiens_hsa043801.78540379
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.75093704
22Toxoplasmosis_Homo sapiens_hsa051451.49541070
23Hematopoietic cell lineage_Homo sapiens_hsa046401.41302833
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.35338541
25Prion diseases_Homo sapiens_hsa050201.29199549
26Malaria_Homo sapiens_hsa051441.19846748
27Influenza A_Homo sapiens_hsa051641.14082463
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08728506
29Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08483958
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.06219018
31Collecting duct acid secretion_Homo sapiens_hsa049661.02697097
32Mineral absorption_Homo sapiens_hsa049781.02551670
33Systemic lupus erythematosus_Homo sapiens_hsa053221.00550378
34* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90942401
35* Chemokine signaling pathway_Homo sapiens_hsa040620.88280597
36Legionellosis_Homo sapiens_hsa051340.85638489
37Herpes simplex infection_Homo sapiens_hsa051680.83601701
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.83462773
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82585568
40TNF signaling pathway_Homo sapiens_hsa046680.82087953
41Sulfur metabolism_Homo sapiens_hsa009200.81873991
42Primary bile acid biosynthesis_Homo sapiens_hsa001200.80713668
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78453321
44NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76183007
45Salmonella infection_Homo sapiens_hsa051320.75839296
46Arachidonic acid metabolism_Homo sapiens_hsa005900.74626391
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70502049
48Ether lipid metabolism_Homo sapiens_hsa005650.69265042
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68010458
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63051018
51Linoleic acid metabolism_Homo sapiens_hsa005910.62315455
52Histidine metabolism_Homo sapiens_hsa003400.61585427
53B cell receptor signaling pathway_Homo sapiens_hsa046620.59745635
54Fructose and mannose metabolism_Homo sapiens_hsa000510.59340400
55PPAR signaling pathway_Homo sapiens_hsa033200.56003763
56Vibrio cholerae infection_Homo sapiens_hsa051100.54722690
57Amoebiasis_Homo sapiens_hsa051460.49353704
58Renin-angiotensin system_Homo sapiens_hsa046140.48755291
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.48211653
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48128792
61Apoptosis_Homo sapiens_hsa042100.47998444
62Sphingolipid metabolism_Homo sapiens_hsa006000.47590278
63African trypanosomiasis_Homo sapiens_hsa051430.46997654
64Galactose metabolism_Homo sapiens_hsa000520.43815905
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43477293
66Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43050498
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42738303
68Hepatitis C_Homo sapiens_hsa051600.40768373
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39927937
70HTLV-I infection_Homo sapiens_hsa051660.37863695
71Measles_Homo sapiens_hsa051620.37752132
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.35624962
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33877868
74Shigellosis_Homo sapiens_hsa051310.30996168
75Fat digestion and absorption_Homo sapiens_hsa049750.28283039
76Platelet activation_Homo sapiens_hsa046110.26382423
77Ovarian steroidogenesis_Homo sapiens_hsa049130.26169449
78Glutathione metabolism_Homo sapiens_hsa004800.24073857
79Bladder cancer_Homo sapiens_hsa052190.22568636
80GnRH signaling pathway_Homo sapiens_hsa049120.22006091
81Primary immunodeficiency_Homo sapiens_hsa053400.21909547
82T cell receptor signaling pathway_Homo sapiens_hsa046600.21426491
83VEGF signaling pathway_Homo sapiens_hsa043700.21041073
84Endocytosis_Homo sapiens_hsa041440.19549346
85Epstein-Barr virus infection_Homo sapiens_hsa051690.17302423
86Vitamin digestion and absorption_Homo sapiens_hsa049770.17144583
87Tryptophan metabolism_Homo sapiens_hsa003800.15880347
88Hepatitis B_Homo sapiens_hsa051610.15366093
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.14591759
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.13951570
91Pancreatic secretion_Homo sapiens_hsa049720.13048004
92ABC transporters_Homo sapiens_hsa020100.13008750
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.12571246
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.11687138
95Pentose phosphate pathway_Homo sapiens_hsa000300.11320130
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.11089968
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.07870311
98Prolactin signaling pathway_Homo sapiens_hsa049170.07329311
99Protein digestion and absorption_Homo sapiens_hsa049740.07050536
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.06940558

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