CCL19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)7.94589021
2negative regulation of interleukin-10 production (GO:0032693)5.87889034
3peptide catabolic process (GO:0043171)5.78505603
4regulation of T cell tolerance induction (GO:0002664)5.62147115
5positive regulation of receptor biosynthetic process (GO:0010870)5.59557623
6cellular protein complex localization (GO:0034629)5.56813646
7T-helper 1 type immune response (GO:0042088)5.46829869
8oxygen transport (GO:0015671)5.42832884
9* positive regulation of antigen processing and presentation (GO:0002579)5.38687274
10positive regulation of pseudopodium assembly (GO:0031274)5.38184653
11leukocyte tethering or rolling (GO:0050901)5.37354962
12myeloid dendritic cell differentiation (GO:0043011)5.35512694
13positive regulation of type 2 immune response (GO:0002830)5.34360968
14regulation of chronic inflammatory response (GO:0002676)5.17815710
15regulation of lipoprotein particle clearance (GO:0010984)5.13213638
16positive regulation of tolerance induction (GO:0002645)5.10594872
17striated muscle atrophy (GO:0014891)5.05751034
18* regulation of antigen processing and presentation (GO:0002577)5.02319895
19antigen processing and presentation of endogenous antigen (GO:0019883)5.01207842
20regulation of cellular extravasation (GO:0002691)4.98719679
21NIK/NF-kappaB signaling (GO:0038061)4.94782814
22* regulation of T-helper 1 cell differentiation (GO:0045625)4.92905711
23muscle atrophy (GO:0014889)4.90640899
24skeletal muscle adaptation (GO:0043501)4.85084729
25regulation of pseudopodium assembly (GO:0031272)4.82978971
26regulation of activation of Janus kinase activity (GO:0010533)4.79306850
27production of molecular mediator involved in inflammatory response (GO:0002532)4.78713027
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.76103827
29synaptic vesicle maturation (GO:0016188)4.76004300
30substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.72678683
31substrate-independent telencephalic tangential migration (GO:0021826)4.72678683
32regulation of tolerance induction (GO:0002643)4.68339185
33antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.64603530
34trivalent inorganic anion homeostasis (GO:0072506)4.63762491
35phosphate ion homeostasis (GO:0055062)4.63762491
36kynurenine metabolic process (GO:0070189)4.59641409
37skeletal muscle tissue regeneration (GO:0043403)4.53883052
38cellular anion homeostasis (GO:0030002)4.50010869
39tryptophan catabolic process (GO:0006569)4.47396500
40indole-containing compound catabolic process (GO:0042436)4.47396500
41indolalkylamine catabolic process (GO:0046218)4.47396500
42synapsis (GO:0007129)4.47210008
43myeloid dendritic cell activation (GO:0001773)4.35946778
44positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.31015549
45sympathetic nervous system development (GO:0048485)4.28880589
46negative regulation of muscle hypertrophy (GO:0014741)4.28283489
47heterotypic cell-cell adhesion (GO:0034113)4.27772515
48regulation of natural killer cell differentiation (GO:0032823)4.26948355
49amine biosynthetic process (GO:0009309)4.26473140
50cellular biogenic amine biosynthetic process (GO:0042401)4.26473140
51interferon-gamma-mediated signaling pathway (GO:0060333)4.23983126
52detection of bacterium (GO:0016045)4.19734676
53superoxide anion generation (GO:0042554)4.18682975
54collecting duct development (GO:0072044)4.17284094
55* positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.14112613
56hydrogen peroxide catabolic process (GO:0042744)4.14011471
57negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 4.09454848
58detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.08814962
59response to gravity (GO:0009629)4.07528088
60single strand break repair (GO:0000012)4.05395526
61regulation of bile acid biosynthetic process (GO:0070857)4.01332904
62cellular response to ATP (GO:0071318)4.00800125
63immunoglobulin mediated immune response (GO:0016064)3.91682114
64renal absorption (GO:0070293)3.90520464
65cellular response to type I interferon (GO:0071357)3.90303058
66type I interferon signaling pathway (GO:0060337)3.90303058
67ovulation from ovarian follicle (GO:0001542)3.89646244
68response to type I interferon (GO:0034340)3.89329600
69regulation of memory T cell differentiation (GO:0043380)3.87366062
70positive regulation of urine volume (GO:0035810)3.83675818
71detection of other organism (GO:0098543)3.80946217
72angiotensin maturation (GO:0002003)3.78835287
73catecholamine biosynthetic process (GO:0042423)3.75263774
74catechol-containing compound biosynthetic process (GO:0009713)3.75263774
75positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.74645878
76* positive regulation of granulocyte chemotaxis (GO:0071624)3.74645406
77regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3.73190002
78regulation of interleukin-10 production (GO:0032653)3.70024473
79complement activation, classical pathway (GO:0006958)3.67472961
80regulation of MHC class II biosynthetic process (GO:0045346)3.66993989
81* dendritic cell chemotaxis (GO:0002407)3.65335387
82negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.65133288
83nitric oxide biosynthetic process (GO:0006809)3.62728649
84glutathione biosynthetic process (GO:0006750)3.59063391
85negative regulation of skeletal muscle tissue development (GO:0048642)3.56221551
86cellular response to interferon-gamma (GO:0071346)3.53470954
87defense response to protozoan (GO:0042832)3.52395946
88* positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.52097031
89aorta morphogenesis (GO:0035909)3.50905922
90eosinophil migration (GO:0072677)3.50208826
91response to interferon-gamma (GO:0034341)3.49956554
92positive regulation of cholesterol efflux (GO:0010875)3.49498153
93* positive regulation of T-helper cell differentiation (GO:0045624)3.49487590
94* positive regulation of interleukin-12 production (GO:0032735)3.49436597
95* regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.48523599
96regulation of vitamin metabolic process (GO:0030656)3.48308266
97negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.47385437
98regulation of type 2 immune response (GO:0002828)3.46809237
99positive regulation of T cell mediated cytotoxicity (GO:0001916)3.46808291
100bundle of His cell to Purkinje myocyte communication (GO:0086069)3.46795482
101positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.46150352
102tryptophan metabolic process (GO:0006568)3.45997265
103* dendritic cell differentiation (GO:0097028)3.45800378
104* regulation of interleukin-12 production (GO:0032655)3.45475266
105sexual reproduction (GO:0019953)3.42207580
106regulation of interferon-gamma biosynthetic process (GO:0045072)3.41139930
107neurotransmitter catabolic process (GO:0042135)3.40421474
108leukotriene biosynthetic process (GO:0019370)3.38806674
109negative regulation of interleukin-12 production (GO:0032695)3.37870276
110regulation of alpha-beta T cell proliferation (GO:0046640)3.36570867
111positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)3.32421353
112positive regulation of gamma-delta T cell activation (GO:0046645)3.28600030
113nonribosomal peptide biosynthetic process (GO:0019184)3.26895544
114positive regulation of interleukin-10 production (GO:0032733)3.25090714
115negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.24286035
116negative regulation of cell killing (GO:0031342)3.24286035
117regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.22575178
118regulation of vitamin D biosynthetic process (GO:0060556)3.21802945
119antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.21599848
120positive regulation of alpha-beta T cell proliferation (GO:0046641)3.21143143
121regulation of mononuclear cell migration (GO:0071675)3.21043932
122pyrimidine dimer repair (GO:0006290)3.20928248
123positive regulation of sterol transport (GO:0032373)3.20424939
124positive regulation of cholesterol transport (GO:0032376)3.20424939
125* regulation of dendritic cell antigen processing and presentation (GO:0002604)3.20385582
126positive regulation of natural killer cell differentiation (GO:0032825)3.19670149
127biotin metabolic process (GO:0006768)3.19536736
128regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.19153769
129potassium ion homeostasis (GO:0055075)3.17747001
130lymphocyte chemotaxis (GO:0048247)3.15531699
131negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.15351649
132renal tubule development (GO:0061326)3.14163636
133vocalization behavior (GO:0071625)3.14075113
134* positive regulation of neutrophil chemotaxis (GO:0090023)3.11168856
135* positive regulation of neutrophil migration (GO:1902624)3.11168856
136regulation of integrin activation (GO:0033623)3.10951954
137positive regulation of T cell migration (GO:2000406)3.10548446
138protein complex localization (GO:0031503)3.08101416
139* regulation of T-helper cell differentiation (GO:0045622)3.07843039
140response to protozoan (GO:0001562)3.07477618
141T-helper cell differentiation (GO:0042093)3.07171126
142CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.07171126
143skin development (GO:0043588)3.06919460
144germinal center formation (GO:0002467)3.06648854
145regulation of receptor biosynthetic process (GO:0010869)3.05942115
146gas transport (GO:0015669)3.04030160
147response to muscle activity (GO:0014850)3.03123404
148lipoxygenase pathway (GO:0019372)3.02765129
149amine catabolic process (GO:0009310)3.02281469
150cellular biogenic amine catabolic process (GO:0042402)3.02281469
151* positive regulation of glycoprotein biosynthetic process (GO:0010560)3.01993393
152complement activation (GO:0006956)3.01907785
153hydrogen peroxide metabolic process (GO:0042743)3.01781991
154positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.00802311
155regulation of inflammatory response to antigenic stimulus (GO:0002861)3.00476033
156* regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.00278085
157regulation of cAMP-dependent protein kinase activity (GO:2000479)2.99589848
158fatty acid homeostasis (GO:0055089)2.99079905
159leukotriene metabolic process (GO:0006691)2.98628098
160regulation of T cell migration (GO:2000404)2.96964116
161axonal fasciculation (GO:0007413)2.96796160
162positive regulation of defense response to virus by host (GO:0002230)2.94772395
163B cell mediated immunity (GO:0019724)2.93004034
164interferon-gamma secretion (GO:0072643)2.92645157
165adhesion of symbiont to host cell (GO:0044650)2.92451498
166virion attachment to host cell (GO:0019062)2.92451498
167positive regulation of lymphocyte migration (GO:2000403)2.91998455
168regulation of cytokine secretion involved in immune response (GO:0002739)2.91994549
169positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.86794817
170* T cell costimulation (GO:0031295)2.86335702
171* regulation of T-helper 1 type immune response (GO:0002825)2.85134639
172positive regulation of DNA-templated transcription, initiation (GO:2000144)2.81808711
173* lymphocyte costimulation (GO:0031294)2.81633213
174regulation of regulatory T cell differentiation (GO:0045589)2.81193287
175regulation of interleukin-8 biosynthetic process (GO:0045414)2.79587159
176neuron recognition (GO:0008038)2.77836551
177regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.76783925
178regulation of natural killer cell activation (GO:0032814)2.76709695
179regulation of urine volume (GO:0035809)2.76429506
180positive regulation of cAMP-mediated signaling (GO:0043950)2.76324467
181urea cycle (GO:0000050)2.76199850
182urea metabolic process (GO:0019627)2.76199850
183positive regulation of interleukin-17 production (GO:0032740)2.73414627
184regulation of RIG-I signaling pathway (GO:0039535)2.72269742
185* positive regulation of glycoprotein metabolic process (GO:1903020)2.72264569
186imidazole-containing compound metabolic process (GO:0052803)11.9372473

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.89208933
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.63989517
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.94770084
4VDR_22108803_ChIP-Seq_LS180_Human3.14688202
5STAT4_19710469_ChIP-ChIP_TH1__Mouse2.46720770
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.42312636
7NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.40366887
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.34872393
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.32926147
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.31161923
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.29367452
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.26589223
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.24742233
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.22891083
15DROSHA_22980978_ChIP-Seq_HELA_Human2.22807913
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.16593642
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.09525154
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.09525154
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.08029217
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.07884306
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.99631732
22EED_16625203_ChIP-ChIP_MESCs_Mouse1.97918374
23* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.96882982
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.93741110
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.91667307
26LXR_22292898_ChIP-Seq_THP-1_Human1.89817193
27TRIM28_21343339_ChIP-Seq_HEK293_Human1.88032150
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.87746229
29ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.83670847
30GBX2_23144817_ChIP-Seq_PC3_Human1.83118188
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.76510677
32MTF2_20144788_ChIP-Seq_MESCs_Mouse1.75958302
33SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.73049282
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.67233279
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66948796
36EZH2_22144423_ChIP-Seq_EOC_Human1.65858439
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.64143453
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63450334
39VDR_24763502_ChIP-Seq_THP-1_Human1.62976462
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.62423154
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.62160627
42VDR_21846776_ChIP-Seq_THP-1_Human1.61109215
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.59387060
44EGR1_19032775_ChIP-ChIP_M12_Human1.59241645
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.57783860
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53600330
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.52939979
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.51799786
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.51374596
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.47634211
51Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.46526949
52TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.46452608
53IRF8_22096565_ChIP-ChIP_GC-B_Human1.46441376
54TP53_18474530_ChIP-ChIP_U2OS_Human1.45894549
55RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45282998
56RUNX_20019798_ChIP-Seq_JUKART_Human1.45116474
57MAF_26560356_Chip-Seq_TH1_Human1.42700084
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.42379016
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.42003603
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39598615
61RXR_22158963_ChIP-Seq_LIVER_Mouse1.39373859
62CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.38289987
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.37181111
64CDX2_20551321_ChIP-Seq_CACO-2_Human1.37162634
65BCAT_22108803_ChIP-Seq_LS180_Human1.36295967
66CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34313170
67PPARA_22158963_ChIP-Seq_LIVER_Mouse1.31428003
68TAF15_26573619_Chip-Seq_HEK293_Human1.30820079
69EGR1_19374776_ChIP-ChIP_THP-1_Human1.30281080
70ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29195452
71ERG_21242973_ChIP-ChIP_JURKAT_Human1.28999078
72IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.28724735
73CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28605768
74CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27201940
75ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26355256
76BRD4_27068464_Chip-Seq_AML-cells_Mouse1.25520289
77STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.24912704
78VDR_24787735_ChIP-Seq_THP-1_Human1.24157563
79RUNX1_22412390_ChIP-Seq_EML_Mouse1.22655269
80GATA1_22025678_ChIP-Seq_K562_Human1.22156802
81MYB_26560356_Chip-Seq_TH2_Human1.22151384
82SPI1_23127762_ChIP-Seq_K562_Human1.21258406
83P300_19829295_ChIP-Seq_ESCs_Human1.21131581
84CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20056603
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19848791
86RACK7_27058665_Chip-Seq_MCF-7_Human1.18159385
87GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18145221
88CBP_20019798_ChIP-Seq_JUKART_Human1.17686475
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17686475
90ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17675350
91TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.17620809
92MYC_22102868_ChIP-Seq_BL_Human1.16058418
93MYB_26560356_Chip-Seq_TH1_Human1.15331127
94PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.15076926
95STAT1_20625510_ChIP-Seq_HELA_Human1.15020427
96SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14949885
97UTX_26944678_Chip-Seq_JUKART_Human1.14179560
98FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.13736755
99PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12671729
100IGF1R_20145208_ChIP-Seq_DFB_Human1.12367412
101TCF7_22412390_ChIP-Seq_EML_Mouse1.11803816
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11540812
103BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11533494
104PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10757322
105* BCL6_27268052_Chip-Seq_Bcells_Human1.10722711
106SPI1_23547873_ChIP-Seq_NB4_Human1.10532425
107ESR1_21235772_ChIP-Seq_MCF-7_Human1.09911660
108SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09842084
109TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08939594
110NANOG_18555785_Chip-Seq_ESCs_Mouse1.08801820
111KDM2B_26808549_Chip-Seq_DND41_Human1.08654735
112AR_25329375_ChIP-Seq_VCAP_Human1.08524055
113FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.08332443
114* BCOR_27268052_Chip-Seq_Bcells_Human1.07995361
115PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07739327
116LXR_22158963_ChIP-Seq_LIVER_Mouse1.07625369
117FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07590662
118SOX2_20726797_ChIP-Seq_SW620_Human1.06651944
119SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06196164
120TCF4_18268006_ChIP-ChIP_LS174T_Human1.06182926
121CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05920311
122MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05493226
123ESR2_21235772_ChIP-Seq_MCF-7_Human1.05284303
124BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.04889410
125TP53_20018659_ChIP-ChIP_R1E_Mouse1.04809769
126ER_23166858_ChIP-Seq_MCF-7_Human1.04609492
127EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03766632
128DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03019056
129NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02982736
130RING1B_27294783_Chip-Seq_NPCs_Mouse1.02624616
131P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02440750
132NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01562282
133RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01524584
134PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.01458242
135STAT1_17558387_ChIP-Seq_HELA_Human1.01090600
136NFE2_27457419_Chip-Seq_LIVER_Mouse1.00931962
137KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00922493
138CMYC_18555785_Chip-Seq_ESCs_Mouse1.00829523
139SA1_27219007_Chip-Seq_Bcells_Human1.00539054
140GATA1_19941827_ChIP-Seq_MEL_Mouse1.00339016
141MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00111182
142SMAD3_21741376_ChIP-Seq_EPCs_Human1.00035149
143EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99904910
144ARNT_22903824_ChIP-Seq_MCF-7_Human0.99480212
145CDX2_22108803_ChIP-Seq_LS180_Human0.98486453
146SCL_19346495_ChIP-Seq_HPC-7_Human0.98186994
147GATA1_19941826_ChIP-Seq_K562_Human0.97582148
148SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97512347
149E2F1_18555785_Chip-Seq_ESCs_Mouse0.97039120
150CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96964042
151STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96942252
152EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96786501
153CLOCK_20551151_ChIP-Seq_293T_Human0.96690335
154NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96486499
155NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96486499
156RUNX1_27457419_Chip-Seq_LIVER_Mouse0.96417934
157NMYC_18555785_Chip-Seq_ESCs_Mouse0.95732164
158STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.95045377
159SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94431254
160AHR_22903824_ChIP-Seq_MCF-7_Human0.94022187
161GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93932696
162OCT4_18555785_Chip-Seq_ESCs_Mouse0.93127713
163CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93049446
164FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92670359
165NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92237248
166PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.91521438
167P53_22387025_ChIP-Seq_ESCs_Mouse0.91413246
168MAF_26560356_Chip-Seq_TH2_Human0.91255558
169SOX2_18555785_Chip-Seq_ESCs_Mouse0.90677461
170KDM2B_26808549_Chip-Seq_REH_Human0.90555448
171LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90357536
172FOXO3_23340844_ChIP-Seq_DLD1_Human0.90310321
173CBX2_27304074_Chip-Seq_ESCs_Mouse0.90121267
174TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90030360
175EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.89837690
176SA1_27219007_Chip-Seq_ERYTHROID_Human0.89378370
177REST_21632747_ChIP-Seq_MESCs_Mouse0.89034948
178IRF8_27001747_Chip-Seq_BMDM_Mouse0.88806333
179KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88488885
180GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88365524
181CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88055938
182SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87748585
183GATA4_25053715_ChIP-Seq_YYC3_Human0.87295370
184MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.86426629
185PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86323085

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat7.86674685
2MP0002876_abnormal_thyroid_physiology7.13525252
3MP0005645_abnormal_hypothalamus_physiol5.15225967
4MP0004510_myositis4.59155377
5MP0003303_peritoneal_inflammation4.32482767
6MP0001348_abnormal_lacrimal_gland3.86875607
7MP0003724_increased_susceptibility_to3.66029555
8MP0001346_abnormal_lacrimal_gland3.63225837
9* MP0000685_abnormal_immune_system3.50764936
10MP0001835_abnormal_antigen_presentation3.49018379
11MP0005647_abnormal_sex_gland3.44474999
12MP0002735_abnormal_chemical_nociception3.20272126
13MP0003436_decreased_susceptibility_to2.89577262
14MP0001873_stomach_inflammation2.87586866
15MP0005310_abnormal_salivary_gland2.82430344
16MP0002138_abnormal_hepatobiliary_system2.75078637
17MP0002139_abnormal_hepatobiliary_system2.61266804
18MP0002877_abnormal_melanocyte_morpholog2.43030641
19MP0002160_abnormal_reproductive_system2.37712377
20MP0009840_abnormal_foam_cell2.28959903
21MP0005451_abnormal_body_composition2.21910181
22MP0003879_abnormal_hair_cell2.17643056
23MP0005671_abnormal_response_to2.08962148
24MP0004947_skin_inflammation2.00663696
25MP0003959_abnormal_lean_body1.91753883
26MP0005360_urolithiasis1.86471826
27MP0001533_abnormal_skeleton_physiology1.81294385
28MP0010234_abnormal_vibrissa_follicle1.81190685
29MP0006082_CNS_inflammation1.77425234
30MP0005058_abnormal_lysosome_morphology1.75297144
31MP0005503_abnormal_tendon_morphology1.71236089
32MP0005166_decreased_susceptibility_to1.70138438
33MP0001501_abnormal_sleep_pattern1.65229918
34MP0003075_altered_response_to1.53116710
35MP0003191_abnormal_cellular_cholesterol1.52664520
36MP0003638_abnormal_response/metabolism_1.46710373
37MP0003866_abnormal_defecation1.46505525
38MP0009333_abnormal_splenocyte_physiolog1.46231839
39MP0000003_abnormal_adipose_tissue1.36146894
40MP0002971_abnormal_brown_adipose1.34777957
41MP0001790_abnormal_immune_system1.31453965
42MP0005387_immune_system_phenotype1.31453965
43MP0008057_abnormal_DNA_replication1.29713784
44MP0002734_abnormal_mechanical_nocicepti1.27009909
45MP0003448_altered_tumor_morphology1.25553024
46MP0002733_abnormal_thermal_nociception1.24790634
47MP0000604_amyloidosis1.23290014
48MP0002148_abnormal_hypersensitivity_rea1.22311606
49MP0005389_reproductive_system_phenotype1.21463165
50MP0000343_altered_response_to1.20458405
51MP0003806_abnormal_nucleotide_metabolis1.19782762
52MP0000470_abnormal_stomach_morphology1.14828039
53MP0010352_gastrointestinal_tract_polyps1.12792412
54MP0003868_abnormal_feces_composition1.12345022
55MP0001666_abnormal_nutrient_absorption1.11538435
56MP0003172_abnormal_lysosome_physiology1.09812406
57MP0002398_abnormal_bone_marrow1.09520441
58MP0002108_abnormal_muscle_morphology1.08877964
59MP0003183_abnormal_peptide_metabolism1.06803077
60MP0002998_abnormal_bone_remodeling1.05757672
61MP0000858_altered_metastatic_potential1.05714975
62MP0001764_abnormal_homeostasis1.04565026
63MP0003195_calcinosis1.04511388
64MP0009764_decreased_sensitivity_to1.04285240
65MP0001853_heart_inflammation1.04191159
66MP0008004_abnormal_stomach_pH1.03667679
67MP0002277_abnormal_respiratory_mucosa1.03018369
68MP0003045_fibrosis1.02350961
69MP0005025_abnormal_response_to1.02102619
70MP0005365_abnormal_bile_salt1.01811741
71MP0009115_abnormal_fat_cell0.99447936
72MP0009785_altered_susceptibility_to0.98688177
73MP0004858_abnormal_nervous_system0.98560839
74* MP0002429_abnormal_blood_cell0.98459757
75MP0006054_spinal_hemorrhage0.97640344
76MP0009278_abnormal_bone_marrow0.96996228
77MP0000490_abnormal_crypts_of0.96813648
78MP0001800_abnormal_humoral_immune0.96411376
79MP0000465_gastrointestinal_hemorrhage0.94876630
80MP0009763_increased_sensitivity_to0.94801958
81MP0001485_abnormal_pinna_reflex0.94049326
82MP0009379_abnormal_foot_pigmentation0.92625083
83MP0008260_abnormal_autophagy0.91673848
84MP0002933_joint_inflammation0.91435777
85MP0008874_decreased_physiological_sensi0.86462732
86MP0005275_abnormal_skin_tensile0.86084558
87MP0003880_abnormal_central_pattern0.85165367
88MP0005334_abnormal_fat_pad0.84849864
89MP0002722_abnormal_immune_system0.84778264
90MP0004019_abnormal_vitamin_homeostasis0.83927502
91MP0003091_abnormal_cell_migration0.83658951
92MP0005381_digestive/alimentary_phenotyp0.83221284
93MP0003300_gastrointestinal_ulcer0.83109751
94MP0003763_abnormal_thymus_physiology0.82414286
95MP0000538_abnormal_urinary_bladder0.81253622
96MP0005397_hematopoietic_system_phenotyp0.80421137
97MP0001545_abnormal_hematopoietic_system0.80421137
98MP0000689_abnormal_spleen_morphology0.80129638
99MP0002405_respiratory_system_inflammati0.80051661
100MP0000681_abnormal_thyroid_gland0.78342683
101MP0001881_abnormal_mammary_gland0.77718549
102MP0010386_abnormal_urinary_bladder0.77660907
103MP0002089_abnormal_postnatal_growth/wei0.77219904
104MP0005167_abnormal_blood-brain_barrier0.77022834
105MP0000249_abnormal_blood_vessel0.76317427
106MP0001970_abnormal_pain_threshold0.76217200
107MP0005448_abnormal_energy_balance0.75204777
108MP0003453_abnormal_keratinocyte_physiol0.74467447
109MP0005000_abnormal_immune_tolerance0.74189418
110MP0002136_abnormal_kidney_physiology0.72616277
111MP0000467_abnormal_esophagus_morphology0.72190079
112MP0001845_abnormal_inflammatory_respons0.71722475
113MP0005390_skeleton_phenotype0.71602525
114MP0009765_abnormal_xenobiotic_induced0.71303140
115MP0002928_abnormal_bile_duct0.71176932
116MP0004270_analgesia0.70607707
117MP0001216_abnormal_epidermal_layer0.69782024
118MP0000678_abnormal_parathyroid_gland0.68849118
119MP0003828_pulmonary_edema0.68616552
120MP0001851_eye_inflammation0.67152070
121MP0005584_abnormal_enzyme/coenzyme_acti0.66758654
122MP0006276_abnormal_autonomic_nervous0.66157790
123MP0002166_altered_tumor_susceptibility0.64669522
124MP0000613_abnormal_salivary_gland0.64464328
125MP0004264_abnormal_extraembryonic_tissu0.63606749
126MP0005165_increased_susceptibility_to0.62104289
127MP0002796_impaired_skin_barrier0.61017248
128MP0005164_abnormal_response_to0.60789140
129MP0000383_abnormal_hair_follicle0.60149392
130MP0000609_abnormal_liver_physiology0.60116378
131MP0003329_amyloid_beta_deposits0.60104317
132MP0003690_abnormal_glial_cell0.60049095
133MP0000477_abnormal_intestine_morphology0.59746235
134MP0002970_abnormal_white_adipose0.59405118
135MP0002452_abnormal_antigen_presenting0.58997651
136MP0002723_abnormal_immune_serum0.58085723
137MP0002069_abnormal_eating/drinking_beha0.57299442
138MP0010155_abnormal_intestine_physiology0.55918028
139MP0004782_abnormal_surfactant_physiolog0.55893337
140MP0008872_abnormal_physiological_respon0.54087661
141MP0000579_abnormal_nail_morphology0.52419392
142MP0004134_abnormal_chest_morphology0.51445000
143MP0001819_abnormal_immune_cell0.50364491
144MP0002420_abnormal_adaptive_immunity0.49397769
145MP0002272_abnormal_nervous_system0.49220910
146MP0008469_abnormal_protein_level0.49085271
147MP0005464_abnormal_platelet_physiology0.47774602
148MP0001663_abnormal_digestive_system0.47506780
149MP0003890_abnormal_embryonic-extraembry0.47147694
150MP0002909_abnormal_adrenal_gland0.47054551
151MP0009643_abnormal_urine_homeostasis0.46915901
152MP0002693_abnormal_pancreas_physiology0.46126039
153MP0010678_abnormal_skin_adnexa0.46077830
154MP0002419_abnormal_innate_immunity0.44766901
155MP0002006_tumorigenesis0.44053071
156* MP0000716_abnormal_immune_system0.39631352
157MP0002896_abnormal_bone_mineralization0.39508939

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)6.44709420
2Increased IgE level (HP:0003212)6.05595107
3Chronic mucocutaneous candidiasis (HP:0002728)6.01707196
4Recurrent cutaneous fungal infections (HP:0011370)6.01707196
5Malnutrition (HP:0004395)5.24015999
6Aplasia/Hypoplasia of the spleen (HP:0010451)5.22258456
7Keratoconjunctivitis (HP:0001096)5.07760629
8Eczematoid dermatitis (HP:0000976)5.06066495
9Gastrointestinal infarctions (HP:0005244)4.84199283
10Type I diabetes mellitus (HP:0100651)4.79714997
11Prolonged neonatal jaundice (HP:0006579)4.62424398
12Confusion (HP:0001289)4.55189927
13Abnormality of the middle phalanx of the 5th finger (HP:0004219)4.08829373
14Asplenia (HP:0001746)3.97835687
15Vasculitis (HP:0002633)3.93112060
16Glomerulonephritis (HP:0000099)3.88900420
17Plantar hyperkeratosis (HP:0007556)3.82572403
18Recurrent skin infections (HP:0001581)3.79786965
19Optic neuritis (HP:0100653)3.76019730
20Retrobulbar optic neuritis (HP:0100654)3.76019730
21Abnormality of the phalanges of the 5th finger (HP:0004213)3.72996778
22Palmoplantar hyperkeratosis (HP:0000972)3.69642523
23Complement deficiency (HP:0004431)3.65771836
24Symphalangism affecting the phalanges of the hand (HP:0009773)3.63627450
25Abnormality of complement system (HP:0005339)3.61571283
26Abnormal pupillary function (HP:0007686)3.59383169
27Abnormality of macrophages (HP:0004311)3.57084265
28Hydroxyprolinuria (HP:0003080)3.55213431
29Abnormality of proline metabolism (HP:0010907)3.55213431
30Hemoptysis (HP:0002105)3.53121552
31Tongue fasciculations (HP:0001308)3.51991808
32Type 2 muscle fiber atrophy (HP:0003554)3.51290712
33Congenital malformation of the right heart (HP:0011723)3.51082943
34Double outlet right ventricle (HP:0001719)3.51082943
35Chronic diarrhea (HP:0002028)3.50801793
36Recurrent fungal infections (HP:0002841)3.50482696
37Right ventricular cardiomyopathy (HP:0011663)3.45982633
38Palmar hyperkeratosis (HP:0010765)3.41501991
39Abnormality of calcium-phosphate metabolism (HP:0100530)3.37725011
40Upper limb muscle weakness (HP:0003484)3.37255552
41Emphysema (HP:0002097)3.33686512
42Poikilocytosis (HP:0004447)3.30794115
43Muscle fibrillation (HP:0010546)3.29726687
44Hypercortisolism (HP:0001578)3.24538050
45Abnormality of the gastric mucosa (HP:0004295)3.21757402
46Colitis (HP:0002583)3.20575361
47Reticulocytosis (HP:0001923)3.14803314
48Muscle fiber atrophy (HP:0100295)3.12940866
49Chronic otitis media (HP:0000389)3.11345137
50Onycholysis (HP:0001806)3.10263418
51Hypergammaglobulinemia (HP:0010702)3.09533425
52Abnormality of the nasal mucosa (HP:0000433)3.08555906
53Recurrent bronchitis (HP:0002837)3.07381734
54Pulmonary infiltrates (HP:0002113)3.06789625
55Fatigable weakness (HP:0003473)2.94759450
56Abnormality of the neuromuscular junction (HP:0003398)2.94759450
57Abnormality of glycolipid metabolism (HP:0010969)2.91196277
58Abnormality of liposaccharide metabolism (HP:0010968)2.91196277
59Abnormality of glycosphingolipid metabolism (HP:0004343)2.91196277
60Nephritis (HP:0000123)2.90908337
61Recurrent gram-negative bacterial infections (HP:0005420)2.90572874
62Xerostomia (HP:0000217)2.89469880
63Recurrent viral infections (HP:0004429)2.85264228
64Keratoconjunctivitis sicca (HP:0001097)2.82146371
65IgA deficiency (HP:0002720)2.80978878
66Agammaglobulinemia (HP:0004432)2.79562565
67Gingivitis (HP:0000230)2.78124225
68Thin bony cortex (HP:0002753)2.76277116
69Recurrent bacterial skin infections (HP:0005406)2.75015873
70Supernumerary nipples (HP:0002558)2.74990982
71Chest pain (HP:0100749)2.74597183
72Respiratory distress (HP:0002098)2.74588807
73Tetraparesis (HP:0002273)2.74356211
74Milia (HP:0001056)2.72805983
75Nasal polyposis (HP:0100582)2.71361973
76Abnormal delayed hypersensitivity skin test (HP:0002963)2.70233786
77Hypertensive crisis (HP:0100735)2.69923703
78Hyperglycemia (HP:0003074)2.67610131
79Dysostosis multiplex (HP:0000943)2.66232665
80Recurrent abscess formation (HP:0002722)2.61864899
81Truncus arteriosus (HP:0001660)2.61704964
82Autoimmune thrombocytopenia (HP:0001973)2.61160986
83Absent speech (HP:0001344)2.59581347
84Recurrent pneumonia (HP:0006532)2.56534927
85Restrictive lung disease (HP:0002091)2.55029032
86Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.51274187
87Elevated erythrocyte sedimentation rate (HP:0003565)2.50731841
88Loss of speech (HP:0002371)2.43449624
89Enlarged kidneys (HP:0000105)2.43310117
90Increased IgM level (HP:0003496)2.43036991
91Amyloidosis (HP:0011034)2.40658493
92Chronic obstructive pulmonary disease (HP:0006510)2.40128559
93Obstructive lung disease (HP:0006536)2.40128559
94Premature loss of primary teeth (HP:0006323)2.39669991
95Weak cry (HP:0001612)2.36740410
96Encephalitis (HP:0002383)2.36712212
97Interstitial pulmonary disease (HP:0006530)2.36699030
98Urticaria (HP:0001025)2.36218430
99Abnormality of glutamine family amino acid metabolism (HP:0010902)2.33997628
100Purpura (HP:0000979)2.33758644
101Gastrointestinal stroma tumor (HP:0100723)2.33722494
102Hypoplasia of the uterus (HP:0000013)2.33403855
103Gastrointestinal inflammation (HP:0004386)2.33364602
104Amaurosis fugax (HP:0100576)2.33186041
105Abnormality of placental membranes (HP:0011409)2.32679662
106Amniotic constriction ring (HP:0009775)2.32679662
107Myositis (HP:0100614)2.31398394
108Joint swelling (HP:0001386)2.29428549
109Keratitis (HP:0000491)2.24358031
110Abnormality of cells of the lymphoid lineage (HP:0012140)2.23776938
111Recurrent lower respiratory tract infections (HP:0002783)2.22772067
112Abnormality of the pleura (HP:0002103)2.21887799
113Fragile skin (HP:0001030)2.18079346
114Periodontitis (HP:0000704)2.17636178
115Lymphopenia (HP:0001888)2.15603195
116Abnormality of small intestinal villus morphology (HP:0011472)2.14930624
117Villous atrophy (HP:0011473)2.14930624
118Autoimmune hemolytic anemia (HP:0001890)2.14645171
119Amelogenesis imperfecta (HP:0000705)2.14363617
120Abnormality of monocarboxylic acid metabolism (HP:0010996)2.14135467
121Arthralgia (HP:0002829)2.13953643
122Abnormality of T cell number (HP:0011839)2.11849028
123Annular pancreas (HP:0001734)2.11510777
124Hypophosphatemia (HP:0002148)2.10250650
125Cholelithiasis (HP:0001081)2.07141906
126Short 5th finger (HP:0009237)2.06811044
127Anorexia (HP:0002039)2.06067628
128Skin rash (HP:0000988)2.05822164
129Nausea (HP:0002018)2.05188940
130Hyperglycinuria (HP:0003108)2.04854375
131Hypoplasia of dental enamel (HP:0006297)2.04830748
132Orchitis (HP:0100796)2.04783413
133Hyperparathyroidism (HP:0000843)2.04004307
134Fibular aplasia (HP:0002990)2.03762979
135Abnormality of B cell number (HP:0010975)2.03189309
136Urinary glycosaminoglycan excretion (HP:0003541)2.03089488
137Mucopolysacchariduria (HP:0008155)2.03089488
138Pustule (HP:0200039)2.02746643
139Increased cerebral lipofuscin (HP:0011813)2.01270021
140T lymphocytopenia (HP:0005403)2.01106864
141Bone pain (HP:0002653)2.00915098
142Vacuolated lymphocytes (HP:0001922)2.00363597
143Tubulointerstitial fibrosis (HP:0005576)1.99512618
144Pulmonary embolism (HP:0002204)1.98350810
145Panhypogammaglobulinemia (HP:0003139)1.98259151
146Abnormality of mucopolysaccharide metabolism (HP:0011020)1.98180774
147Abnormality of polysaccharide metabolism (HP:0011012)1.98180774
148Abnormality of glycosaminoglycan metabolism (HP:0004371)1.98180774
149Ventricular tachycardia (HP:0004756)1.97829278
150Vertebral compression fractures (HP:0002953)1.97352845
151Spontaneous hematomas (HP:0007420)1.95747854
152Fragile nails (HP:0001808)1.94951748
153Synostosis involving bones of the hand (HP:0004278)1.93590947
154Inflammation of the large intestine (HP:0002037)1.93447760
155Mediastinal lymphadenopathy (HP:0100721)1.93360290
156Abnormal gallbladder morphology (HP:0012437)1.91708703
157Hypoparathyroidism (HP:0000829)1.91158662
158Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.90811607
159Cellulitis (HP:0100658)1.88552348
160Aplasia/hypoplasia of the uterus (HP:0008684)1.87574700
161Meningitis (HP:0001287)1.86250998
162Hematochezia (HP:0002573)1.84972744
163Intellectual disability, mild (HP:0001256)1.82440946
164Sepsis (HP:0100806)1.81318155
165Hepatitis (HP:0012115)1.80682286
166Esophageal varix (HP:0002040)1.78003566
167Gangrene (HP:0100758)1.77959584
168Seborrheic dermatitis (HP:0001051)1.77091480
169Potter facies (HP:0002009)1.76750426

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.54179272
2DYRK34.67018039
3DYRK1B4.41291816
4BMPR23.80559109
5RIPK13.79683813
6MAP4K12.89046375
7GRK72.83032641
8ERBB32.82641030
9EPHA32.68985564
10IRAK42.68587855
11PRPF4B2.42403747
12MST1R2.38503799
13NME12.03414762
14EPHB11.88287870
15NTRK11.82953996
16IKBKE1.76966221
17FGFR41.74640901
18ERN11.72827667
19BCR1.69835793
20CSK1.68262821
21SYK1.65741711
22ACVR1B1.65100838
23NLK1.54076211
24PINK11.48588723
25TYK21.48322525
26DYRK1A1.44921809
27ZAP701.44773403
28JAK31.44225922
29CDC42BPA1.41640901
30NME21.40808819
31DAPK21.40599665
32TXK1.38948591
33ADRBK21.38216224
34IKBKB1.34404740
35PRKCQ1.29186210
36CHUK1.28126827
37MST41.27790884
38PTK61.26843537
39MAP3K111.25522330
40FGR1.24355634
41MAP3K11.17534684
42TAOK11.15701113
43IRAK11.12389861
44CDK31.12205773
45MAPK151.11627318
46FRK1.05768148
47TNK21.05468736
48TAOK21.02908500
49ITK1.02824214
50TBK11.02512081
51LYN0.99832763
52RIPK40.97882307
53JAK20.95180026
54PLK20.94712572
55SIK30.94702864
56BTK0.94076053
57HIPK20.94034585
58TGFBR20.93972585
59TNIK0.93738618
60MKNK10.92397734
61EPHA20.91583164
62NEK90.90919519
63TRIB30.90761487
64EPHB20.90760860
65GRK50.88947630
66SMG10.88514868
67MAP3K60.87989796
68PRKG20.85292368
69EPHA40.83322807
70FGFR30.82928284
71PRKCD0.82303932
72PTK20.80684031
73MYLK0.80366552
74LCK0.79109110
75TESK20.79043906
76PRKCI0.78695526
77IRAK30.78395337
78PRKAA20.77199049
79LRRK20.76546781
80RAF10.75913781
81CSF1R0.75434817
82FER0.75330191
83SCYL20.69977131
84TYRO30.66758808
85PKN10.65876021
86HCK0.65767081
87PRKCE0.64275496
88MUSK0.64177850
89NTRK30.63550364
90BMPR1B0.62336899
91TESK10.61945387
92MAP3K120.61500843
93MAP3K100.61084933
94JAK10.60793367
95MKNK20.60647515
96DMPK0.58368845
97STK100.58341282
98SIK10.57332447
99PAK60.55269781
100EIF2AK20.55258001
101MATK0.54499935
102MAP3K30.54207317
103PDGFRA0.50823801
104PDPK10.50789552
105TEC0.50270571
106CLK10.50198433
107PIK3CG0.49858258
108CASK0.48734949
109CDK80.47556546
110TGFBR10.47237956
111MAP3K130.47043705
112MAP2K70.46212081
113MAPKAPK50.45967066
114MAP3K70.45585904
115CAMK10.45152494
116MAP3K40.44183372
117TIE10.44020744
118NTRK20.43410690
119BMX0.43214559
120MAPK70.41653001
121MAP2K20.40230968
122PIM20.39647948
123SRC0.39569298
124CAMK2G0.39441557
125AKT30.38706892
126PDK10.38671318
127ROCK20.38428877
128FYN0.38208584
129GRK60.37839700
130CDK60.36582715
131DDR20.36032684
132DAPK30.35614594
133MAPKAPK20.35149884
134ERBB40.35067528
135SIK20.34849746
136PAK30.34723040
137TSSK60.33517514
138KDR0.33511397
139MAPK110.32864886
140CAMKK20.32749332
141ARAF0.32737372
142BLK0.32644341
143KIT0.32174618
144MET0.31568925
145MELK0.31021693
146FES0.30044618
147PRKACA0.30036116
148PIM10.29532751
149STK240.28881010
150EGFR0.28818726
151KSR10.28724738
152PRKD20.27359904
153MAPK40.26770188
154CDK190.26018005
155INSR0.24936139
156MOS0.24733732
157MAPK30.23612892
158RPS6KA20.23027839

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.61377020
2Histidine metabolism_Homo sapiens_hsa003404.58376175
3Intestinal immune network for IgA production_Homo sapiens_hsa046724.40266541
4Asthma_Homo sapiens_hsa053103.73092521
5Cyanoamino acid metabolism_Homo sapiens_hsa004603.67319918
6Graft-versus-host disease_Homo sapiens_hsa053323.27904895
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.84518976
8Primary immunodeficiency_Homo sapiens_hsa053402.64724505
9Linoleic acid metabolism_Homo sapiens_hsa005912.28372160
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.27886626
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.18862993
12Antigen processing and presentation_Homo sapiens_hsa046122.12329252
13Arginine biosynthesis_Homo sapiens_hsa002202.07959487
14Viral myocarditis_Homo sapiens_hsa054161.99666913
15Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.88972099
16Phenylalanine metabolism_Homo sapiens_hsa003601.86961519
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.80959554
18Influenza A_Homo sapiens_hsa051641.62483414
19Herpes simplex infection_Homo sapiens_hsa051681.47105731
20Other glycan degradation_Homo sapiens_hsa005111.46386358
21Ether lipid metabolism_Homo sapiens_hsa005651.41543756
22Renin-angiotensin system_Homo sapiens_hsa046141.38791993
23* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.35036952
24African trypanosomiasis_Homo sapiens_hsa051431.30403488
25Leishmaniasis_Homo sapiens_hsa051401.28497381
26Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.27056747
27* NF-kappa B signaling pathway_Homo sapiens_hsa040641.26303067
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.24709132
29Hematopoietic cell lineage_Homo sapiens_hsa046401.23105120
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.22621649
31Arachidonic acid metabolism_Homo sapiens_hsa005901.21795455
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19137189
33Sulfur metabolism_Homo sapiens_hsa009201.19129330
34Autoimmune thyroid disease_Homo sapiens_hsa053201.16400943
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14017503
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12693432
37Malaria_Homo sapiens_hsa051441.12513120
38Nicotine addiction_Homo sapiens_hsa050331.09874304
39Measles_Homo sapiens_hsa051621.09504049
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09274117
41Hepatitis C_Homo sapiens_hsa051601.09127921
42Mineral absorption_Homo sapiens_hsa049781.03610222
43Allograft rejection_Homo sapiens_hsa053301.03262468
44Lysosome_Homo sapiens_hsa041421.02875417
45Amphetamine addiction_Homo sapiens_hsa050311.02615987
46Osteoclast differentiation_Homo sapiens_hsa043801.02057086
47ABC transporters_Homo sapiens_hsa020100.99350692
48Rheumatoid arthritis_Homo sapiens_hsa053230.96348940
49NOD-like receptor signaling pathway_Homo sapiens_hsa046210.94192444
50Salivary secretion_Homo sapiens_hsa049700.89781845
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89680276
52Olfactory transduction_Homo sapiens_hsa047400.89009330
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83023147
54Vitamin digestion and absorption_Homo sapiens_hsa049770.80305442
55Fructose and mannose metabolism_Homo sapiens_hsa000510.75325974
56Glycerophospholipid metabolism_Homo sapiens_hsa005640.75076679
57Melanoma_Homo sapiens_hsa052180.74135754
58Jak-STAT signaling pathway_Homo sapiens_hsa046300.73101050
59Glutamatergic synapse_Homo sapiens_hsa047240.72275733
60Tyrosine metabolism_Homo sapiens_hsa003500.71266447
61Calcium signaling pathway_Homo sapiens_hsa040200.70557922
62Nitrogen metabolism_Homo sapiens_hsa009100.69343518
63Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68508775
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67865573
65Salmonella infection_Homo sapiens_hsa051320.67507778
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66992230
67Epstein-Barr virus infection_Homo sapiens_hsa051690.66928765
68Phototransduction_Homo sapiens_hsa047440.66819258
69Prion diseases_Homo sapiens_hsa050200.63631520
70Ras signaling pathway_Homo sapiens_hsa040140.63451252
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.61539734
72Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59931293
73Tuberculosis_Homo sapiens_hsa051520.59417911
74Serotonergic synapse_Homo sapiens_hsa047260.58549392
75Circadian entrainment_Homo sapiens_hsa047130.58483445
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.57621068
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57600617
78PPAR signaling pathway_Homo sapiens_hsa033200.57113190
79Hepatitis B_Homo sapiens_hsa051610.56922693
80Amoebiasis_Homo sapiens_hsa051460.56542362
81Prolactin signaling pathway_Homo sapiens_hsa049170.56146535
82* Chemokine signaling pathway_Homo sapiens_hsa040620.54954411
83Acute myeloid leukemia_Homo sapiens_hsa052210.54692375
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.54417901
85Collecting duct acid secretion_Homo sapiens_hsa049660.53556939
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52176394
87Protein digestion and absorption_Homo sapiens_hsa049740.50113930
88Systemic lupus erythematosus_Homo sapiens_hsa053220.50048464
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49880978
90Tryptophan metabolism_Homo sapiens_hsa003800.48802575
91Toxoplasmosis_Homo sapiens_hsa051450.48739084
92Shigellosis_Homo sapiens_hsa051310.48709712
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.47302867
94GABAergic synapse_Homo sapiens_hsa047270.46108675
95Dorso-ventral axis formation_Homo sapiens_hsa043200.45775156
96Arginine and proline metabolism_Homo sapiens_hsa003300.45232309
97Staphylococcus aureus infection_Homo sapiens_hsa051500.44935757
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44431242
99Choline metabolism in cancer_Homo sapiens_hsa052310.44394738
100T cell receptor signaling pathway_Homo sapiens_hsa046600.44157855
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44017682
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43776823
103MAPK signaling pathway_Homo sapiens_hsa040100.42830132
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41559635
105Dilated cardiomyopathy_Homo sapiens_hsa054140.41331200
106Fat digestion and absorption_Homo sapiens_hsa049750.39651435
107Synaptic vesicle cycle_Homo sapiens_hsa047210.39614797
108B cell receptor signaling pathway_Homo sapiens_hsa046620.39550830
109Phagosome_Homo sapiens_hsa041450.38477793
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38095274
111HTLV-I infection_Homo sapiens_hsa051660.37976911
112Inositol phosphate metabolism_Homo sapiens_hsa005620.37483039
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37459758
114Morphine addiction_Homo sapiens_hsa050320.37320697
115Pyruvate metabolism_Homo sapiens_hsa006200.36741884
116Taste transduction_Homo sapiens_hsa047420.36731199
117Vibrio cholerae infection_Homo sapiens_hsa051100.35983250
118Pertussis_Homo sapiens_hsa051330.34134638
119Glycerolipid metabolism_Homo sapiens_hsa005610.33468971
120Apoptosis_Homo sapiens_hsa042100.32906775
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32782826
122Galactose metabolism_Homo sapiens_hsa000520.32708791
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32186786
124Thyroid hormone synthesis_Homo sapiens_hsa049180.32036384
125Glutathione metabolism_Homo sapiens_hsa004800.31777682
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.31585476
127Steroid hormone biosynthesis_Homo sapiens_hsa001400.28635790
128TNF signaling pathway_Homo sapiens_hsa046680.28466931
129Type I diabetes mellitus_Homo sapiens_hsa049400.28126192
130Legionellosis_Homo sapiens_hsa051340.27468740
131Pancreatic secretion_Homo sapiens_hsa049720.27162676
132Bladder cancer_Homo sapiens_hsa052190.27091005
133Gastric acid secretion_Homo sapiens_hsa049710.26545501
134Complement and coagulation cascades_Homo sapiens_hsa046100.26269959
135ECM-receptor interaction_Homo sapiens_hsa045120.26161381
136Insulin resistance_Homo sapiens_hsa049310.25492247
137Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25103784
138Notch signaling pathway_Homo sapiens_hsa043300.25075071
139Rap1 signaling pathway_Homo sapiens_hsa040150.24930600
140p53 signaling pathway_Homo sapiens_hsa041150.23738659
141Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22380032
142Drug metabolism - other enzymes_Homo sapiens_hsa009830.21478971
143Fatty acid degradation_Homo sapiens_hsa000710.19649158
144Sphingolipid metabolism_Homo sapiens_hsa006000.18006070
145Caffeine metabolism_Homo sapiens_hsa002320.17752173
146VEGF signaling pathway_Homo sapiens_hsa043700.17014616
147Chemical carcinogenesis_Homo sapiens_hsa052040.16544286
148Vascular smooth muscle contraction_Homo sapiens_hsa042700.13896642
149Viral carcinogenesis_Homo sapiens_hsa052030.12072477
150Pancreatic cancer_Homo sapiens_hsa052120.10779933

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