CCL20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene displays chemotactic activity for lymphocytes and can repress proliferation of myeloid progenitors. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)8.45464835
2xenobiotic catabolic process (GO:0042178)7.69216183
3regulation of branching involved in prostate gland morphogenesis (GO:0060687)7.58467040
4response to nitrosative stress (GO:0051409)7.27958869
5regulation of regulatory T cell differentiation (GO:0045589)7.16780325
6positive regulation of endothelial cell apoptotic process (GO:2000353)7.13545240
7regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)7.09918683
8positive regulation of interleukin-17 production (GO:0032740)7.00963530
9positive regulation of isotype switching (GO:0045830)6.91955355
10regulation of isotype switching to IgG isotypes (GO:0048302)6.75387753
11positive regulation of actin filament depolymerization (GO:0030836)6.68004485
12surfactant homeostasis (GO:0043129)6.60495001
13positive regulation of DNA recombination (GO:0045911)5.95301516
14bundle of His cell to Purkinje myocyte communication (GO:0086069)5.86553320
15negative regulation of fatty acid transport (GO:2000192)5.84189342
16positive regulation of icosanoid secretion (GO:0032305)5.50793771
17purine ribonucleotide transport (GO:0015868)5.47798533
18positive regulation of catenin import into nucleus (GO:0035413)5.42442573
19regulation of vitamin D biosynthetic process (GO:0060556)5.41586143
20negative regulation of bone remodeling (GO:0046851)5.41015408
21adenine nucleotide transport (GO:0051503)5.33694333
22negative regulation of B cell apoptotic process (GO:0002903)5.31848645
23hemidesmosome assembly (GO:0031581)5.25257315
24negative regulation of chondrocyte differentiation (GO:0032331)5.25255813
25regulation of immunoglobulin production (GO:0002637)5.21318672
26chemical homeostasis within a tissue (GO:0048875)5.20985497
27positive regulation of immunoglobulin mediated immune response (GO:0002891)5.16701374
28positive regulation of B cell mediated immunity (GO:0002714)5.16701374
29regulation of podosome assembly (GO:0071801)5.12265444
30fat-soluble vitamin biosynthetic process (GO:0042362)5.09197356
31positive regulation of heterotypic cell-cell adhesion (GO:0034116)5.05792367
32positive regulation of interleukin-12 production (GO:0032735)4.98015830
33mesenchyme morphogenesis (GO:0072132)4.96171840
34regulation of isotype switching (GO:0045191)4.88728073
35regulation of chronic inflammatory response (GO:0002676)4.85105723
36purine nucleotide transport (GO:0015865)4.76995009
37regulation of odontogenesis of dentin-containing tooth (GO:0042487)4.74832175
38somatic diversification of immunoglobulins involved in immune response (GO:0002208)4.70603094
39isotype switching (GO:0045190)4.70603094
40somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)4.70603094
41regulation of endothelial cell chemotaxis (GO:2001026)4.69511450
42regulation of icosanoid secretion (GO:0032303)4.63709723
43negative regulation of tissue remodeling (GO:0034104)4.51940224
44regulation of vitamin metabolic process (GO:0030656)4.49717127
45regulation of interleukin-17 production (GO:0032660)4.48807456
46positive regulation of fatty acid transport (GO:2000193)4.43198056
47regulation of interleukin-12 production (GO:0032655)4.25150359
48regulation of phospholipase A2 activity (GO:0032429)4.24851598
49negative regulation of fibroblast apoptotic process (GO:2000270)4.24493399
50positive regulation of immunoglobulin production (GO:0002639)4.21961667
51positive regulation of activated T cell proliferation (GO:0042104)4.17031479
52myeloid dendritic cell differentiation (GO:0043011)4.11511757
53negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.04399324
54positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.04002163
55prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.98842928
56cell proliferation involved in kidney development (GO:0072111)3.96461518
57positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)3.95570395
58nucleotide transmembrane transport (GO:1901679)3.95178701
59regulation of heat generation (GO:0031650)3.94823373
60regulation of cell proliferation involved in kidney development (GO:1901722)3.93706130
61regulation of B cell apoptotic process (GO:0002902)3.93099109
62renal absorption (GO:0070293)3.91082274
63endocardial cushion morphogenesis (GO:0003203)3.88303087
64B cell proliferation (GO:0042100)3.83201028
65negative regulation of bone resorption (GO:0045779)3.80635290
66negative regulation of axon extension involved in axon guidance (GO:0048843)3.79808404
67positive regulation of p38MAPK cascade (GO:1900745)3.77517672
68mesenchymal cell proliferation (GO:0010463)3.75156058
69positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.71641178
70regulation of immunoglobulin mediated immune response (GO:0002889)3.70560231
71response to magnesium ion (GO:0032026)3.67642131
72sodium-independent organic anion transport (GO:0043252)3.66369193
73regulation of cytokine secretion involved in immune response (GO:0002739)3.65589641
74regulation of prostaglandin secretion (GO:0032306)3.64468032
75L-serine transport (GO:0015825)3.63698985
76glutathione derivative biosynthetic process (GO:1901687)3.60138820
77glutathione derivative metabolic process (GO:1901685)3.60138820
78regulation of B cell mediated immunity (GO:0002712)3.59701214
79negative regulation of cartilage development (GO:0061037)3.59450224
80desmosome organization (GO:0002934)3.58664850
81positive regulation of chemokine biosynthetic process (GO:0045080)3.56215629
82regulation of cardioblast proliferation (GO:0003264)3.52435291
83regulation of secondary heart field cardioblast proliferation (GO:0003266)3.52435291
84cellular response to vitamin D (GO:0071305)3.50225736
85signal complex assembly (GO:0007172)3.47270026
86positive regulation of defense response to virus by host (GO:0002230)3.46807234
87serine transport (GO:0032329)3.46547572
88positive regulation of tissue remodeling (GO:0034105)3.46481742
89regulation of transforming growth factor beta1 production (GO:0032908)3.45785593
90GTP biosynthetic process (GO:0006183)3.44069980
91positive regulation of interferon-gamma production (GO:0032729)3.42613032
92induction of positive chemotaxis (GO:0050930)3.42469675
93regulation of tyrosine phosphorylation of STAT protein (GO:0042509)3.42375228
94regulation of catenin import into nucleus (GO:0035412)3.42059759
95positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.40195758
96negative regulation of keratinocyte proliferation (GO:0010839)3.35026553
97regulation of memory T cell differentiation (GO:0043380)3.33409049
98positive regulation of prostaglandin secretion (GO:0032308)3.32680863
99positive regulation of heat generation (GO:0031652)3.32360893
100regulation of fever generation (GO:0031620)3.31156281
101negative regulation of hormone metabolic process (GO:0032351)3.30885285
102negative regulation of hormone biosynthetic process (GO:0032353)3.30885285
103negative regulation of interleukin-12 production (GO:0032695)3.30231350
104positive regulation of T-helper cell differentiation (GO:0045624)3.27597415
105myeloid dendritic cell activation (GO:0001773)3.27585311
106regulation of glomerulus development (GO:0090192)3.27161943
107regulation of glucocorticoid metabolic process (GO:0031943)3.25641448
108regulation of production of molecular mediator of immune response (GO:0002700)3.24926188
109B cell activation involved in immune response (GO:0002312)3.24769005
110cell surface receptor signaling pathway involved in heart development (GO:0061311)3.23041546
111benzene-containing compound metabolic process (GO:0042537)3.21829556
112positive regulation of astrocyte differentiation (GO:0048711)3.19965990
113cellular glucuronidation (GO:0052695)3.17654488
114positive regulation of monocyte chemotaxis (GO:0090026)3.17542762
115regulation of T-helper 1 cell differentiation (GO:0045625)3.17044956
116regulation of chemokine secretion (GO:0090196)3.16235566
117phenylpropanoid metabolic process (GO:0009698)3.16180469
118positive regulation of JAK-STAT cascade (GO:0046427)3.15983354
119regulation of chemokine biosynthetic process (GO:0045073)3.13012320
120aorta morphogenesis (GO:0035909)3.12800744
121positive regulation of NF-kappaB import into nucleus (GO:0042346)3.12604000
122proteasome assembly (GO:0043248)3.10244211
123positive regulation of protein depolymerization (GO:1901881)3.10145227
124negative regulation of osteoblast proliferation (GO:0033689)3.09921555
125regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.09310214
126regulation of NF-kappaB import into nucleus (GO:0042345)3.07259210
127positive regulation of cell cycle checkpoint (GO:1901978)3.06641941
128atrioventricular valve morphogenesis (GO:0003181)3.06076223
129response to peptidoglycan (GO:0032494)3.04997426
130regulation of activated T cell proliferation (GO:0046006)3.03726687
131regulation of p38MAPK cascade (GO:1900744)3.02977995
132somatic recombination of immunoglobulin gene segments (GO:0016447)3.02350860
133regulation of T cell tolerance induction (GO:0002664)3.02327948
134positive regulation of adaptive immune response based on somatic recombination of immune receptors b3.00959035
135lipopolysaccharide-mediated signaling pathway (GO:0031663)3.00587667
136cellular protein catabolic process (GO:0044257)3.00197111
137positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.00134124
138regulation of heterotypic cell-cell adhesion (GO:0034114)2.99757097
139cell proliferation involved in metanephros development (GO:0072203)2.99644752
140regulation of endothelial cell apoptotic process (GO:2000351)2.98851139
141neutrophil activation involved in immune response (GO:0002283)2.98226233
142positive regulation of T-helper 1 type immune response (GO:0002827)2.97165189
143planar cell polarity pathway involved in neural tube closure (GO:0090179)2.96854773
144positive regulation of tolerance induction (GO:0002645)2.96349193
145cellular response to vitamin (GO:0071295)2.96341164
146cardiac epithelial to mesenchymal transition (GO:0060317)2.94603245
147regulation of mesenchymal cell apoptotic process (GO:2001053)2.94462540
148positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.93584224
149axonal fasciculation (GO:0007413)2.93102687
150UTP biosynthetic process (GO:0006228)2.93032913
151positive regulation of B cell proliferation (GO:0030890)2.92847076
152glucuronate metabolic process (GO:0019585)2.92729927
153uronic acid metabolic process (GO:0006063)2.92729927
154regulation of T-helper cell differentiation (GO:0045622)2.91865039
155regulation of fibroblast apoptotic process (GO:2000269)2.90164110
156positive regulation of lymphocyte mediated immunity (GO:0002708)2.90090986
157negative regulation of axon guidance (GO:1902668)2.89176381
158positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.88979144
159natural killer cell activation (GO:0030101)2.88563815
160regulation of interleukin-12 biosynthetic process (GO:0045075)2.88016562
161negative regulation of NF-kappaB import into nucleus (GO:0042347)2.87791463
162branching involved in salivary gland morphogenesis (GO:0060445)2.87135779
163regulation of membrane protein ectodomain proteolysis (GO:0051043)2.86966533
164regulation of osteoblast proliferation (GO:0033688)2.84916005
165positive regulation of adaptive immune response (GO:0002821)2.84795728
166negative regulation of lipid storage (GO:0010888)2.84093716
167negative regulation of myeloid cell apoptotic process (GO:0033033)2.83677963
168positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)2.82510807
169one-carbon compound transport (GO:0019755)2.82205571
170response to vitamin D (GO:0033280)2.80966209
171negative regulation of cytokine production involved in immune response (GO:0002719)2.80818545
172regulation of ruffle assembly (GO:1900027)2.80352948
173cellular response to prostaglandin stimulus (GO:0071379)2.80243944
174mesodermal cell differentiation (GO:0048333)2.79484071
175positive regulation of cartilage development (GO:0061036)2.79454829
176negative regulation of lipase activity (GO:0060192)2.79242265
177modulation of growth of symbiont involved in interaction with host (GO:0044144)2.77852813
178regulation of growth of symbiont in host (GO:0044126)2.77852813
179negative regulation of growth of symbiont in host (GO:0044130)2.77852813
180negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.77852813
181regulation of natural killer cell differentiation (GO:0032823)2.76917049
182positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.76397945
183tolerance induction (GO:0002507)2.75953666
184positive regulation of positive chemotaxis (GO:0050927)2.75890914
185positive regulation of production of molecular mediator of immune response (GO:0002702)2.75177507
186regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.74975847
187dendritic cell differentiation (GO:0097028)2.72840932
188hormone catabolic process (GO:0042447)2.72633547
189negative regulation of protein acetylation (GO:1901984)2.72023659
190regulation of interleukin-2 biosynthetic process (GO:0045076)2.70644179
191regulation of inflammatory response to antigenic stimulus (GO:0002861)2.70185882
192regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.69719622
193leukocyte aggregation (GO:0070486)2.69355484
194leukocyte cell-cell adhesion (GO:0007159)2.69044444
195somatic diversification of immunoglobulins (GO:0016445)2.68934926
196regulation of immunoglobulin secretion (GO:0051023)12.5447968

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.65253657
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.71686063
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.69470887
4STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse4.66286872
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.36512025
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.71238654
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.57412244
8TRIM28_21343339_ChIP-Seq_HEK293_Human3.55906398
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.55077261
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.48792396
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.43273918
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.29218136
13STAT4_19710469_ChIP-ChIP_TH1__Mouse3.26854855
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.13576698
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.12730215
16CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.06189949
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.85288566
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.54746961
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.49113903
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.48999105
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.42097081
22TAF15_26573619_Chip-Seq_HEK293_Human2.30894339
23CLOCK_20551151_ChIP-Seq_293T_Human2.21031183
24IGF1R_20145208_ChIP-Seq_DFB_Human2.17664921
25PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.08375382
26* SOX2_20726797_ChIP-Seq_SW620_Human2.03101687
27MYB_21317192_ChIP-Seq_ERMYB_Mouse2.02349162
28Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.02309917
29ESR2_21235772_ChIP-Seq_MCF-7_Human2.00965826
30CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.94264916
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82328480
32* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.81804785
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.79056181
34SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.77879865
35SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.77879865
36TP53_18474530_ChIP-ChIP_U2OS_Human1.77660310
37* CJUN_26792858_Chip-Seq_BT549_Human1.76039961
38CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.75642108
39SOX9_24532713_ChIP-Seq_HFSC_Mouse1.75545735
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.75002509
41CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.74929578
42CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.71349739
43CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.71032089
44FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.69584577
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67765084
46GATA3_26560356_Chip-Seq_TH2_Human1.66402761
47ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.64730045
48ZNF217_24962896_ChIP-Seq_MCF-7_Human1.61363746
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.59921817
50FOXO3_23340844_ChIP-Seq_DLD1_Human1.58271100
51CDX2_20551321_ChIP-Seq_CACO-2_Human1.57357966
52PPAR_26484153_Chip-Seq_NCI-H1993_Human1.57120615
53NRF2_20460467_ChIP-Seq_MEFs_Mouse1.56500927
54NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.56500927
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.56448747
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.53574909
57GATA1_22025678_ChIP-Seq_K562_Human1.46478330
58MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.45604195
59P63_26484246_Chip-Seq_KERATINOCYTES_Human1.43883131
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43350474
61* EP300_21415370_ChIP-Seq_HL-1_Mouse1.42140120
62EGR1_23403033_ChIP-Seq_LIVER_Mouse1.41365106
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39765143
64CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.39609085
65PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.39051994
66GATA3_27048872_Chip-Seq_THYMUS_Human1.38259646
67KLF5_25053715_ChIP-Seq_YYC3_Human1.38139415
68KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.37214645
69NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.36743134
70STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.36363511
71MYB_26560356_Chip-Seq_TH2_Human1.35557362
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35045010
73VDR_24787735_ChIP-Seq_THP-1_Human1.31636682
74SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.29669668
75SPI1_23547873_ChIP-Seq_NB4_Human1.25904227
76STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21841984
77SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.21416926
78NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20612824
79PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19144524
80STAT1_20625510_ChIP-Seq_HELA_Human1.19062230
81TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18947821
82BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18106958
83EED_16625203_ChIP-ChIP_MESCs_Mouse1.17808995
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.16663033
85EZH2_18974828_ChIP-Seq_MESCs_Mouse1.16563660
86RNF2_18974828_ChIP-Seq_MESCs_Mouse1.16563660
87RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.16228601
88GABP_17652178_ChIP-ChIP_JURKAT_Human1.15973582
89MAF_26560356_Chip-Seq_TH1_Human1.15907477
90* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.15891684
91PU_27001747_Chip-Seq_BMDM_Mouse1.12909385
92ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.12301468
93PPARA_22158963_ChIP-Seq_LIVER_Mouse1.11927421
94HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11822338
95ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.11719318
96HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10275163
97SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.09745431
98SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.09651807
99FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09437037
100TP53_16413492_ChIP-PET_HCT116_Human1.09417615
101SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.09183445
102GATA2_21666600_ChIP-Seq_HMVEC_Human1.09015711
103* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08532521
104TP63_23658742_ChIP-Seq_EP156T_Human1.07894762
105TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07610053
106SMRT_27268052_Chip-Seq_Bcells_Human1.07142614
107CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06256746
108UBF1/2_26484160_Chip-Seq_HMECs_Human1.06030083
109* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05313785
110JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05077518
111TCF4_22108803_ChIP-Seq_LS180_Human1.04472299
112SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03358966
113BCAT_22108803_ChIP-Seq_LS180_Human1.03186820
114TP53_20018659_ChIP-ChIP_R1E_Mouse1.02570114
115NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.01371233
116SMAD3_21741376_ChIP-Seq_HESCs_Human1.01017337
117DCP1A_22483619_ChIP-Seq_HELA_Human0.99204628
118E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98545015
119PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98452100
120FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.98238508
121NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97135184
122RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96946270
123* GATA4_25053715_ChIP-Seq_YYC3_Human0.95746373
124TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95115907
125LXR_22158963_ChIP-Seq_LIVER_Mouse0.93946801
126CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.92643292
127NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91631372
128SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90986038
129SMAD_19615063_ChIP-ChIP_OVARY_Human0.90171841
130KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90028772
131RUNX_20019798_ChIP-Seq_JUKART_Human0.89998924
132RXR_22158963_ChIP-Seq_LIVER_Mouse0.89802757
133* VDR_24763502_ChIP-Seq_THP-1_Human0.88915419
134HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.88749057
135DROSHA_22980978_ChIP-Seq_HELA_Human0.87959684
136JARID2_20075857_ChIP-Seq_MESCs_Mouse0.87957848
137GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87887816
138ZNF263_19887448_ChIP-Seq_K562_Human0.87861189
139EGR1_19032775_ChIP-ChIP_M12_Human0.87298381
140MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.86492349
141BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86302932
142PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85873528
143GATA6_25053715_ChIP-Seq_YYC3_Human0.85552698
144SMAD3_21741376_ChIP-Seq_EPCs_Human0.84963740
145SUZ12_27294783_Chip-Seq_ESCs_Mouse0.84916195
146AR_21572438_ChIP-Seq_LNCaP_Human0.83843774
147SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.83608848
148SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.83298977
149RING1B_27294783_Chip-Seq_NPCs_Mouse0.82470090
150AHR_22903824_ChIP-Seq_MCF-7_Human0.81809513
151BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.81643210
152MTF2_20144788_ChIP-Seq_MESCs_Mouse0.81414754
153MYB_26560356_Chip-Seq_TH1_Human0.80721587
154PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80664832
155SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.80209598
156ESR1_15608294_ChIP-ChIP_MCF-7_Human0.80180655
157GATA1_19941826_ChIP-Seq_K562_Human0.79321540
158LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.79286533
159JARID2_20064375_ChIP-Seq_MESCs_Mouse0.79125305
160GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.78064782
161EGR1_19374776_ChIP-ChIP_THP-1_Human0.77852591
162FLI1_27457419_Chip-Seq_LIVER_Mouse0.77572328
163SMAD4_21741376_ChIP-Seq_HESCs_Human0.77570567
164PU.1_20513432_ChIP-Seq_Bcells_Mouse0.77158759
165* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.77118387
166LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.75958131
167EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.75565597
168TP53_22573176_ChIP-Seq_HFKS_Human0.75200076
169* PCGF2_27294783_Chip-Seq_NPCs_Mouse0.75146680
170MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.75127559
171MYC_18555785_ChIP-Seq_MESCs_Mouse0.75022809
172SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74827309
173SRY_22984422_ChIP-ChIP_TESTIS_Rat0.74795248
174CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.74353012

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.57983774
2MP0010030_abnormal_orbit_morphology4.91938720
3MP0004782_abnormal_surfactant_physiolog4.87335197
4MP0002254_reproductive_system_inflammat4.77732593
5MP0000678_abnormal_parathyroid_gland4.17001267
6MP0009379_abnormal_foot_pigmentation4.04943260
7MP0002877_abnormal_melanocyte_morpholog3.90662192
8MP0008789_abnormal_olfactory_epithelium3.38376760
9MP0003303_peritoneal_inflammation3.33286418
10MP0000685_abnormal_immune_system2.87178627
11MP0003436_decreased_susceptibility_to2.82069871
12MP0005671_abnormal_response_to2.78672546
13MP0002277_abnormal_respiratory_mucosa2.68465193
14MP0001346_abnormal_lacrimal_gland2.63886942
15MP0005000_abnormal_immune_tolerance2.50248032
16MP0002139_abnormal_hepatobiliary_system2.48655117
17MP0008875_abnormal_xenobiotic_pharmacok2.47431326
18MP0000762_abnormal_tongue_morphology2.43788566
19MP0003195_calcinosis2.38476153
20MP0006082_CNS_inflammation2.38323059
21MP0001299_abnormal_eye_distance/2.35124511
22MP0005394_taste/olfaction_phenotype2.33965973
23MP0005499_abnormal_olfactory_system2.33965973
24MP0000465_gastrointestinal_hemorrhage2.31980056
25MP0000579_abnormal_nail_morphology2.31857275
26MP0005025_abnormal_response_to2.23614776
27MP0009384_cardiac_valve_regurgitation2.15365961
28MP0009250_abnormal_appendicular_skeleto1.99038326
29MP0009333_abnormal_splenocyte_physiolog1.95547128
30MP0000049_abnormal_middle_ear1.91724085
31MP0009053_abnormal_anal_canal1.91178616
32MP0009785_altered_susceptibility_to1.90616886
33MP0001800_abnormal_humoral_immune1.88384740
34MP0004510_myositis1.85430284
35MP0009840_abnormal_foam_cell1.76976447
36MP0002723_abnormal_immune_serum1.75046429
37MP0002098_abnormal_vibrissa_morphology1.73914623
38MP0002796_impaired_skin_barrier1.73681663
39MP0004264_abnormal_extraembryonic_tissu1.72700056
40MP0002419_abnormal_innate_immunity1.71245335
41MP0003453_abnormal_keratinocyte_physiol1.65078202
42MP0010368_abnormal_lymphatic_system1.64361831
43MP0002249_abnormal_larynx_morphology1.63563474
44MP0004019_abnormal_vitamin_homeostasis1.62338017
45MP0002452_abnormal_antigen_presenting1.60113069
46MP0002233_abnormal_nose_morphology1.54495562
47MP0005167_abnormal_blood-brain_barrier1.52384869
48MP0001542_abnormal_bone_strength1.50618196
49MP0002060_abnormal_skin_morphology1.50275055
50MP0001845_abnormal_inflammatory_respons1.49102857
51MP0000566_synostosis1.47065499
52MP0000537_abnormal_urethra_morphology1.42467980
53MP0003300_gastrointestinal_ulcer1.39688170
54MP0010678_abnormal_skin_adnexa1.39142983
55MP0010234_abnormal_vibrissa_follicle1.38740198
56MP0000467_abnormal_esophagus_morphology1.34349086
57MP0002234_abnormal_pharynx_morphology1.32911904
58MP0008469_abnormal_protein_level1.32036756
59MP0004134_abnormal_chest_morphology1.31939109
60MP0001849_ear_inflammation1.30733072
61MP0002420_abnormal_adaptive_immunity1.30570213
62MP0001819_abnormal_immune_cell1.28820623
63MP0000383_abnormal_hair_follicle1.22541314
64MP0008004_abnormal_stomach_pH1.21461394
65MP0003890_abnormal_embryonic-extraembry1.20783796
66MP0003806_abnormal_nucleotide_metabolis1.19528283
67MP0005365_abnormal_bile_salt1.18505784
68MP0005360_urolithiasis1.18324168
69MP0002295_abnormal_pulmonary_circulatio1.15153794
70MP0002896_abnormal_bone_mineralization1.14831250
71MP0002876_abnormal_thyroid_physiology1.13913583
72MP0008260_abnormal_autophagy1.12646739
73MP0002396_abnormal_hematopoietic_system1.12387656
74MP0005076_abnormal_cell_differentiation1.10415668
75MP0009278_abnormal_bone_marrow1.09880037
76MP0003941_abnormal_skin_development1.09426787
77MP0005409_darkened_coat_color1.08732211
78MP0001501_abnormal_sleep_pattern1.07084906
79MP0001216_abnormal_epidermal_layer1.04819053
80MP0002751_abnormal_autonomic_nervous1.04703099
81MP0005166_decreased_susceptibility_to1.04081944
82MP0003385_abnormal_body_wall1.03698798
83MP0000163_abnormal_cartilage_morphology1.02789501
84MP0004947_skin_inflammation1.01573771
85MP0000716_abnormal_immune_system1.01512803
86MP0002148_abnormal_hypersensitivity_rea1.01266316
87MP0002006_tumorigenesis1.01158470
88MP0005408_hypopigmentation1.00710403
89MP0002332_abnormal_exercise_endurance0.99502719
90MP0000534_abnormal_ureter_morphology0.99397315
91MP0002138_abnormal_hepatobiliary_system0.99059349
92MP0003329_amyloid_beta_deposits0.98218544
93MP0001270_distended_abdomen0.97814065
94MP0003646_muscle_fatigue0.97175002
95MP0000689_abnormal_spleen_morphology0.95549376
96MP0000858_altered_metastatic_potential0.93148754
97MP0002398_abnormal_bone_marrow0.92552705
98MP0003448_altered_tumor_morphology0.92435301
99MP0010155_abnormal_intestine_physiology0.91598927
100MP0005023_abnormal_wound_healing0.90590654
101MP0000343_altered_response_to0.90523405
102MP0001873_stomach_inflammation0.90364776
103MP0000490_abnormal_crypts_of0.89179323
104MP0002102_abnormal_ear_morphology0.89124653
105MP0004147_increased_porphyrin_level0.89038326
106MP0008872_abnormal_physiological_respon0.88720090
107MP0001881_abnormal_mammary_gland0.88069826
108MP0005058_abnormal_lysosome_morphology0.87346323
109MP0006292_abnormal_olfactory_placode0.87258810
110MP0000604_amyloidosis0.86177273
111MP0003937_abnormal_limbs/digits/tail_de0.85636654
112MP0002722_abnormal_immune_system0.84920846
113MP0000249_abnormal_blood_vessel0.84745422
114MP0005275_abnormal_skin_tensile0.84489353
115MP0000609_abnormal_liver_physiology0.83284278
116MP0003656_abnormal_erythrocyte_physiolo0.83163889
117MP0008438_abnormal_cutaneous_collagen0.81419368
118MP0003075_altered_response_to0.81238514
119MP0001853_heart_inflammation0.81211809
120MP0004381_abnormal_hair_follicle0.80498500
121MP0002429_abnormal_blood_cell0.80187026
122MP0003705_abnormal_hypodermis_morpholog0.79013832
123MP0000681_abnormal_thyroid_gland0.78764106
124MP0002405_respiratory_system_inflammati0.78609623
125MP0002998_abnormal_bone_remodeling0.78550862
126MP0004808_abnormal_hematopoietic_stem0.77928706
127MP0002933_joint_inflammation0.77124335
128MP0001790_abnormal_immune_system0.76346036
129MP0005387_immune_system_phenotype0.76346036
130MP0009763_increased_sensitivity_to0.74769019
131MP0000627_abnormal_mammary_gland0.73546369
132MP0002932_abnormal_joint_morphology0.73395548
133MP0005164_abnormal_response_to0.73172649
134MP0002282_abnormal_trachea_morphology0.73093066
135MP0000613_abnormal_salivary_gland0.72946392
136MP0009764_decreased_sensitivity_to0.72838750
137MP0001177_atelectasis0.72528167
138MP0006054_spinal_hemorrhage0.71649074
139MP0003633_abnormal_nervous_system0.71625807
140MP0003632_abnormal_nervous_system0.70774841
141MP0003786_premature_aging0.70766701
142MP0010771_integument_phenotype0.69371645
143MP0001663_abnormal_digestive_system0.69027021
144MP0003183_abnormal_peptide_metabolism0.68613024
145MP0002090_abnormal_vision0.66849608
146MP0005501_abnormal_skin_physiology0.66236506
147MP0001533_abnormal_skeleton_physiology0.65941965
148MP0000428_abnormal_craniofacial_morphol0.65574098
149MP0005397_hematopoietic_system_phenotyp0.65138723
150MP0001545_abnormal_hematopoietic_system0.65138723
151MP0003724_increased_susceptibility_to0.64217676
152MP0003172_abnormal_lysosome_physiology0.63144366
153MP0003690_abnormal_glial_cell0.63010534
154MP0001188_hyperpigmentation0.62214254
155MP0005448_abnormal_energy_balance0.62152108
156MP0000538_abnormal_urinary_bladder0.61954357
157MP0010352_gastrointestinal_tract_polyps0.61554782
158MP0005197_abnormal_uvea_morphology0.60640183
159MP0010329_abnormal_lipoprotein_level0.60492890
160MP0004883_abnormal_blood_vessel0.59111905
161MP0009765_abnormal_xenobiotic_induced0.58629796
162MP0003763_abnormal_thymus_physiology0.57617740
163MP0005464_abnormal_platelet_physiology0.57460675
164MP0003795_abnormal_bone_structure0.56300437
165MP0005085_abnormal_gallbladder_physiolo0.56271449
166MP0002693_abnormal_pancreas_physiology0.51913285
167MP0005390_skeleton_phenotype0.51651660
168MP0003866_abnormal_defecation0.51416635
169MP0005310_abnormal_salivary_gland0.51359751
170MP0008007_abnormal_cellular_replicative0.51257461
171MP0005165_increased_susceptibility_to0.50897337
172MP0001958_emphysema0.47129259

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of proline metabolism (HP:0010907)9.08000800
2Hydroxyprolinuria (HP:0003080)9.08000800
3Right ventricular cardiomyopathy (HP:0011663)5.86296632
4IgG deficiency (HP:0004315)5.44708474
5Abnormality of glutamine family amino acid metabolism (HP:0010902)5.26945682
6Abnormality of the phalanges of the 2nd finger (HP:0009541)4.93672572
7Multiple enchondromatosis (HP:0005701)4.51218077
8Abnormality of T cell physiology (HP:0011840)4.49565724
9Abnormality of incisor morphology (HP:0011063)4.44464397
10Gingivitis (HP:0000230)4.31625934
11Hyperphosphatemia (HP:0002905)4.29651799
12Plantar hyperkeratosis (HP:0007556)4.17413997
13Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)4.11980877
14Hypergammaglobulinemia (HP:0010702)4.03874146
15Milia (HP:0001056)3.94071785
16Abnormality of the middle phalanges of the toes (HP:0010183)3.89031162
17Myositis (HP:0100614)3.87696926
18Optic neuritis (HP:0100653)3.85555458
19Retrobulbar optic neuritis (HP:0100654)3.85555458
20Fragile nails (HP:0001808)3.79584990
21Atrophic scars (HP:0001075)3.74913794
22Lip pit (HP:0100267)3.73145039
23Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.68418176
24Abnormality of the nasal septum (HP:0000419)3.65768663
25Abnormality of the 2nd finger (HP:0004100)3.63834126
26Onycholysis (HP:0001806)3.53478399
27Orchitis (HP:0100796)3.48201661
28Short nail (HP:0001799)3.33847481
29Long toe (HP:0010511)3.32196638
30Abnormality of T cells (HP:0002843)3.30326440
31Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)3.30318034
32Ridged nail (HP:0001807)3.28417948
33Vacuolated lymphocytes (HP:0001922)3.25361916
34Systemic lupus erythematosus (HP:0002725)3.24672331
35Abnormality of glycolipid metabolism (HP:0010969)3.14090188
36Abnormality of liposaccharide metabolism (HP:0010968)3.14090188
37Abnormality of glycosphingolipid metabolism (HP:0004343)3.14090188
38Fragile skin (HP:0001030)3.09662988
39Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.02813740
40Short hallux (HP:0010109)3.01647391
41Upper motor neuron abnormality (HP:0002127)3.00934221
42Bowed forearm bones (HP:0003956)2.97833529
43Bowing of the arm (HP:0006488)2.97833529
44Down-sloping shoulders (HP:0200021)2.92116590
45Hyperuricemia (HP:0002149)2.88607202
46Increased purine levels (HP:0004368)2.88607202
47Palmoplantar hyperkeratosis (HP:0000972)2.88468913
48Ankyloglossia (HP:0010296)2.88459947
49Palmar hyperkeratosis (HP:0010765)2.87868375
50Mediastinal lymphadenopathy (HP:0100721)2.86354475
51Eczematoid dermatitis (HP:0000976)2.86268082
52Broad hallux (HP:0010055)2.78855086
53Deep venous thrombosis (HP:0002625)2.77729243
54Abnormality of the phalanges of the 5th finger (HP:0004213)2.74842506
55Hepatitis (HP:0012115)2.73105910
56Tetraparesis (HP:0002273)2.72129236
57Radial bowing (HP:0002986)2.65435665
58Aplasia/Hypoplasia of the hallux (HP:0008362)2.64898482
59Bifid scrotum (HP:0000048)2.64322165
60Complement deficiency (HP:0004431)2.62523553
61Myocardial infarction (HP:0001658)2.62386204
62Abnormal trabecular bone morphology (HP:0100671)2.60668910
63Nail dystrophy (HP:0008404)2.59107646
64Stridor (HP:0010307)2.58463258
65Autoimmune thrombocytopenia (HP:0001973)2.56887903
66Keratoconjunctivitis sicca (HP:0001097)2.54657010
67Thick nail (HP:0001805)2.52907681
68Trismus (HP:0000211)2.52232587
69Abnormal sex determination (HP:0012244)2.46944743
70Sex reversal (HP:0012245)2.46944743
71Broad toe (HP:0001837)2.45512444
72Neutropenia (HP:0001875)2.44307825
73Humeroradial synostosis (HP:0003041)2.42040606
74Synostosis involving the elbow (HP:0003938)2.42040606
75Fibular aplasia (HP:0002990)2.41127598
76Mesomelia (HP:0003027)2.38633190
77Gangrene (HP:0100758)2.38237757
78Pulmonary infiltrates (HP:0002113)2.38021388
79Stomach cancer (HP:0012126)2.33625003
80Hydroureter (HP:0000072)2.30893651
81Glomerulonephritis (HP:0000099)2.30440641
82Keratoconjunctivitis (HP:0001096)2.30337429
83Natal tooth (HP:0000695)2.29679017
84Abnormality of purine metabolism (HP:0004352)2.27898315
85Abnormality of macrophages (HP:0004311)2.27363992
86Oligodontia (HP:0000677)2.27352269
87Vertebral compression fractures (HP:0002953)2.26784398
88Recurrent bacterial skin infections (HP:0005406)2.25079734
89Stenosis of the external auditory canal (HP:0000402)2.22170789
90Cheilitis (HP:0100825)2.21986966
91Abnormality of oral frenula (HP:0000190)2.21698095
92Abnormality of the gastric mucosa (HP:0004295)2.20183599
93Sensorimotor neuropathy (HP:0007141)2.18662758
94Urethral obstruction (HP:0000796)2.15628348
95Episodic fever (HP:0001954)2.15461065
96Abnormality of the lower motor neuron (HP:0002366)2.14253597
97Prolonged partial thromboplastin time (HP:0003645)2.13454693
98Rough bone trabeculation (HP:0100670)2.12321963
99Bronchomalacia (HP:0002780)2.11097253
100Ventricular tachycardia (HP:0004756)2.11054712
101Esophageal atresia (HP:0002032)2.06996285
102Palpitations (HP:0001962)2.06002585
103Abnormality of the thoracic spine (HP:0100711)2.05076051
104Dysostosis multiplex (HP:0000943)2.04042016
105Ulnar bowing (HP:0003031)2.02516713
106Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.02248352
107Short 1st metacarpal (HP:0010034)2.02248352
108Abnormal cartilage morphology (HP:0002763)2.01514322
109Deformed tarsal bones (HP:0008119)2.00149037
110Stomatitis (HP:0010280)16.2598874
111Increased IgM level (HP:0003496)10.6493536
112Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.99153291
113Abnormality of the proximal phalanges of the hand (HP:0009834)1.98578981
114Thickened calvaria (HP:0002684)1.98187187
115Abnormality of the common coagulation pathway (HP:0010990)1.97811164
116Low anterior hairline (HP:0000294)1.96958724
117Disinhibition (HP:0000734)1.96559846
118Vasculitis (HP:0002633)1.96543096
119Nausea (HP:0002018)1.96210677
120Increased serum ferritin (HP:0003281)1.95768386
121Dry hair (HP:0011359)1.94658350
122Abnormality of aromatic amino acid family metabolism (HP:0004338)1.94504377
123Arterial thrombosis (HP:0004420)1.93240073
124Gastrointestinal infarctions (HP:0005244)1.93083516
125Abnormality of T cell number (HP:0011839)1.92330770
126Abnormal hemoglobin (HP:0011902)1.91786028
127Abnormality of the incisor (HP:0000676)1.91172812
128Chronic diarrhea (HP:0002028)1.90876108
129Morphological abnormality of the middle ear (HP:0008609)1.90779205
130Pterygium (HP:0001059)1.90022598
131Cubitus valgus (HP:0002967)1.89581703
132Woolly hair (HP:0002224)1.89327874
133Amyloidosis (HP:0011034)1.88425473
134IgA deficiency (HP:0002720)1.87355590
135Abnormality of the distal phalanges of the toes (HP:0010182)1.86882717
136Short metatarsal (HP:0010743)1.86606335
137Selective tooth agenesis (HP:0001592)1.85589085
138Elevated erythrocyte sedimentation rate (HP:0003565)1.85367609
139Abnormality of dentin (HP:0010299)1.85298665
140Type 2 muscle fiber atrophy (HP:0003554)1.84929575
141Pulmonary artery stenosis (HP:0004415)1.84893453
142True hermaphroditism (HP:0010459)1.84770104
143Pustule (HP:0200039)1.84018209
144T lymphocytopenia (HP:0005403)1.82377261
1453-Methylglutaconic aciduria (HP:0003535)1.82212957
146Purpura (HP:0000979)1.82013748
147Malnutrition (HP:0004395)1.81262163
148Abnormality of complement system (HP:0005339)1.80845187
149Flared iliac wings (HP:0002869)1.80215662
150Spastic diplegia (HP:0001264)1.78776712
151Aseptic necrosis (HP:0010885)1.78532554
152Alopecia of scalp (HP:0002293)1.77642534
153Anorexia (HP:0002039)1.77494855
154Inflammation of the large intestine (HP:0002037)1.77144685
155Fair hair (HP:0002286)1.76272909
156Malignant hyperthermia (HP:0002047)1.75486571
157Xerostomia (HP:0000217)1.74992636
158Abnormality of the 1st metacarpal (HP:0010009)1.74222192
159Postural tremor (HP:0002174)1.74145856
160Enlarged kidneys (HP:0000105)1.73860886
161Redundant skin (HP:0001582)1.73181555
162Joint swelling (HP:0001386)1.72950669
163Rectal prolapse (HP:0002035)1.72730059
164Epidermoid cyst (HP:0200040)1.71388669
165Femoral bowing (HP:0002980)1.70727127
166Abnormal biliary tract physiology (HP:0012439)1.70294269
167Bile duct proliferation (HP:0001408)1.70294269
168Sparse scalp hair (HP:0002209)1.69985840
169Coarse hair (HP:0002208)1.69958018
170Loss of speech (HP:0002371)1.69816259
171Autoimmune hemolytic anemia (HP:0001890)1.69730712
172Narrow palate (HP:0000189)1.69702122
173Congenital, generalized hypertrichosis (HP:0004540)1.69147563
174Recurrent gram-negative bacterial infections (HP:0005420)1.69071769
175Advanced eruption of teeth (HP:0006288)1.68899845
176Spastic paraparesis (HP:0002313)1.68706672
177Dysmetric saccades (HP:0000641)1.67730328
178Pulmonary embolism (HP:0002204)1.67202870
179Abnormality of the prostate (HP:0008775)1.66979795
180Oral leukoplakia (HP:0002745)1.65119373
181Muscle fiber atrophy (HP:0100295)1.64895448
182Abnormal pupillary function (HP:0007686)1.63606920
183Polyneuropathy (HP:0001271)1.62049055
184Recurrent abscess formation (HP:0002722)1.61567537
185Hemoptysis (HP:0002105)1.60952820
186Pathologic fracture (HP:0002756)1.59276872
187Acne (HP:0001061)1.58894486
188Abnormality of polysaccharide metabolism (HP:0011012)1.58499867
189Abnormality of glycosaminoglycan metabolism (HP:0004371)1.58499867
190Abnormality of mucopolysaccharide metabolism (HP:0011020)1.58499867
191Recurrent viral infections (HP:0004429)1.57052983
192Poor head control (HP:0002421)1.56905538
193Urinary glycosaminoglycan excretion (HP:0003541)1.55085323
194Mucopolysacchariduria (HP:0008155)1.55085323
195Preauricular skin tag (HP:0000384)1.55083600

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.79786140
2IRAK34.72635930
3RIPK14.51494945
4NME24.37550279
5TAOK24.36389559
6PRPF4B3.34697618
7EPHA23.26415497
8IKBKE3.14948286
9EPHB23.11081679
10BMPR1B2.97726238
11ADRBK22.79387547
12ICK2.56517637
13MAP3K22.51331082
14BMPR22.47088519
15MST42.27470317
16NME12.16478693
17MAP3K142.14809201
18ERBB32.13112258
19STK38L2.06061986
20TXK2.01566748
21INSRR2.00754872
22TBK11.80880374
23TSSK61.80530217
24FGFR31.75759101
25DAPK21.75494404
26PTK61.72737695
27PDK21.67103009
28MATK1.65467196
29TGFBR11.65276578
30FGFR21.64056468
31MAP3K31.59142009
32MAPKAPK51.42365952
33STK101.41526088
34MAP3K101.37420737
35MST1R1.33306085
36MAPKAPK31.31915388
37TYRO31.31283786
38PIM21.28937399
39PTK21.25282023
40MAP2K11.24643792
41MAP2K61.23516995
42WNK11.21646945
43MAP2K21.19511477
44MAP3K121.18331312
45BLK1.18238849
46EPHB11.14719364
47TTN1.12163826
48ALK1.08667527
49MOS1.02853675
50JAK10.97624971
51TEC0.96503062
52SIK30.96162007
53RPS6KB20.95312346
54ERBB20.94761363
55ZAP700.94596619
56TAOK10.93156000
57PAK30.91148166
58LYN0.90604454
59LATS10.90270704
60LCK0.87835587
61IRAK40.83835530
62SIK10.83451650
63RPS6KA60.82920946
64JAK20.80552010
65IRAK10.76100993
66ERN10.75118508
67LRRK20.74643683
68SIK20.73858886
69GRK10.71512567
70STK240.70009112
71RPS6KA50.69820015
72EIF2AK20.69500262
73MAP4K10.69410558
74MYLK0.66966543
75TAOK30.66878080
76LMTK20.66406897
77CDK80.65995738
78CDC42BPA0.65853435
79TYK20.63446686
80PAK40.62315596
81EPHA30.60008919
82BTK0.60002403
83FGR0.59581042
84TGFBR20.59318360
85NLK0.59134812
86IKBKB0.58354519
87DDR20.58197633
88GSK3A0.58178675
89PDGFRB0.57572916
90RPS6KC10.56008012
91RPS6KL10.56008012
92FER0.55178674
93ACVR1B0.54685074
94HIPK20.54204196
95CSK0.53018726
96MAPKAPK20.52533997
97ZAK0.52511000
98TRPM70.51671049
99JAK30.51345410
100DAPK10.50893976
101STK380.50798293
102MAP3K130.50369625
103SYK0.49813668
104SGK20.49680225
105MARK30.49577300
106FGFR10.49329602
107MAPK110.49237030
108EIF2AK30.48637303
109CHUK0.48476311
110ABL20.48180943
111INSR0.46335597
112EIF2AK10.43711384
113TTK0.42519448
114BMX0.41491145
115CAMK40.41041716
116GRK60.40418142
117EGFR0.39714587
118SGK30.39714282
119MAP3K50.38448893
120IGF1R0.38257148
121PDK10.38064092
122NEK60.37207384
123TESK10.36794684
124RPS6KA10.36600712
125PRKCH0.36543374
126CAMK2G0.36481949
127GRK70.35722271
128PIK3CA0.35602365
129PRKG20.35441501
130LATS20.34978548
131CDK60.33874457
132ROCK20.32891131
133GRK50.31919918
134PDGFRA0.31772488
135HCK0.31608038
136CSNK1D0.30359569
137WNK30.30182780
138BCR0.29963510
139ITK0.29367471
140CSNK1E0.28689495
141CSNK1A1L0.28589741
142MET0.28378153
143PIM10.27296981
144MAP3K80.26909624
145SGK2230.26859617
146SGK4940.26859617
147MAP3K110.26381018
148ERBB40.25765392
149IRAK20.25697152
150CSNK1A10.24123989
151EPHA40.23996480
152MAP3K10.23727524
153CAMK2B0.23473216
154PRKCA0.23472934
155PRKAA20.23208757
156RIPK40.22936438
157ROCK10.22313759
158CSF1R0.22180691
159PIK3CG0.22123702
160CAMK2A0.22064362
161MAPK70.21391630
162FGFR40.21306165
163RPS6KA40.21043087
164PRKACG0.20614348
165SRC0.20055510
166DYRK1B0.19939333

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.84939140
2Vitamin B6 metabolism_Homo sapiens_hsa007504.67993886
3Allograft rejection_Homo sapiens_hsa053304.65170842
4Autoimmune thyroid disease_Homo sapiens_hsa053203.90771997
5Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.89784267
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.50540764
7Intestinal immune network for IgA production_Homo sapiens_hsa046723.43210909
8Chemical carcinogenesis_Homo sapiens_hsa052043.39372817
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.13682677
10Graft-versus-host disease_Homo sapiens_hsa053322.97137575
11Glutathione metabolism_Homo sapiens_hsa004802.87776705
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.82706928
13Type I diabetes mellitus_Homo sapiens_hsa049402.72247577
14Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.62895056
15Primary immunodeficiency_Homo sapiens_hsa053402.57132026
16Glycosaminoglycan degradation_Homo sapiens_hsa005312.24983253
17Steroid hormone biosynthesis_Homo sapiens_hsa001402.19316702
18Sulfur metabolism_Homo sapiens_hsa009201.85614880
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.84387859
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.80703624
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.73006466
22Hippo signaling pathway_Homo sapiens_hsa043901.71341156
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.65624053
24* TNF signaling pathway_Homo sapiens_hsa046681.58140586
25Bladder cancer_Homo sapiens_hsa052191.55845775
26* Rheumatoid arthritis_Homo sapiens_hsa053231.52541474
27Retinol metabolism_Homo sapiens_hsa008301.50531218
28Staphylococcus aureus infection_Homo sapiens_hsa051501.48133032
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.44064625
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.34737257
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.33899229
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.33449462
33Measles_Homo sapiens_hsa051621.31683672
34* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.30390272
35African trypanosomiasis_Homo sapiens_hsa051431.26293193
36Phagosome_Homo sapiens_hsa041451.25809409
37Hedgehog signaling pathway_Homo sapiens_hsa043401.25348313
38ECM-receptor interaction_Homo sapiens_hsa045121.24826033
39Adherens junction_Homo sapiens_hsa045201.22579854
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.22100243
41Phenylalanine metabolism_Homo sapiens_hsa003601.22096073
42Small cell lung cancer_Homo sapiens_hsa052221.21988669
43Caffeine metabolism_Homo sapiens_hsa002321.20461141
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.19615725
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.16603184
46Other glycan degradation_Homo sapiens_hsa005111.14753844
47TGF-beta signaling pathway_Homo sapiens_hsa043501.14472231
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.14457261
49ABC transporters_Homo sapiens_hsa020101.11996344
50Apoptosis_Homo sapiens_hsa042101.10232222
51Basal cell carcinoma_Homo sapiens_hsa052171.09536533
52Osteoclast differentiation_Homo sapiens_hsa043801.08887034
53Proteasome_Homo sapiens_hsa030501.08231324
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04860038
55Axon guidance_Homo sapiens_hsa043601.01478794
56Pertussis_Homo sapiens_hsa051331.00951062
57Prostate cancer_Homo sapiens_hsa052150.97231055
58Prion diseases_Homo sapiens_hsa050200.96843915
59Tight junction_Homo sapiens_hsa045300.96599118
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.96558299
61Influenza A_Homo sapiens_hsa051640.96022173
62Amoebiasis_Homo sapiens_hsa051460.95540043
63Toxoplasmosis_Homo sapiens_hsa051450.94627404
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90836349
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89484865
66Prolactin signaling pathway_Homo sapiens_hsa049170.87624945
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.86413395
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86108316
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86020293
70Leishmaniasis_Homo sapiens_hsa051400.85710399
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84919690
72Proteoglycans in cancer_Homo sapiens_hsa052050.79852028
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.78462585
74PPAR signaling pathway_Homo sapiens_hsa033200.78113542
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78070886
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.77954183
77Complement and coagulation cascades_Homo sapiens_hsa046100.76343434
78Protein export_Homo sapiens_hsa030600.75301060
79Shigellosis_Homo sapiens_hsa051310.75106015
80Mineral absorption_Homo sapiens_hsa049780.72548810
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70437850
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69004063
83Nitrogen metabolism_Homo sapiens_hsa009100.68872415
84Focal adhesion_Homo sapiens_hsa045100.68540332
85Legionellosis_Homo sapiens_hsa051340.67346096
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66424340
87Fatty acid biosynthesis_Homo sapiens_hsa000610.65646824
88Salmonella infection_Homo sapiens_hsa051320.65223376
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64604347
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.64103486
91Herpes simplex infection_Homo sapiens_hsa051680.63627865
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62680340
93Circadian rhythm_Homo sapiens_hsa047100.62325534
94Gap junction_Homo sapiens_hsa045400.61623480
95Antigen processing and presentation_Homo sapiens_hsa046120.61500668
96Starch and sucrose metabolism_Homo sapiens_hsa005000.59312203
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58213735
98Vibrio cholerae infection_Homo sapiens_hsa051100.58051998
99Fatty acid metabolism_Homo sapiens_hsa012120.57660542
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56400488
101Basal transcription factors_Homo sapiens_hsa030220.53278821
102Sphingolipid metabolism_Homo sapiens_hsa006000.52307301
103Lysosome_Homo sapiens_hsa041420.51738156
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50964890
105Epstein-Barr virus infection_Homo sapiens_hsa051690.50233157
106Fatty acid degradation_Homo sapiens_hsa000710.50224227
107Steroid biosynthesis_Homo sapiens_hsa001000.49306835
108Tuberculosis_Homo sapiens_hsa051520.48768463
109Thyroid hormone synthesis_Homo sapiens_hsa049180.48245081
110Dilated cardiomyopathy_Homo sapiens_hsa054140.48151883
111FoxO signaling pathway_Homo sapiens_hsa040680.47879923
112Arachidonic acid metabolism_Homo sapiens_hsa005900.47429952
113Systemic lupus erythematosus_Homo sapiens_hsa053220.45218953
114Insulin resistance_Homo sapiens_hsa049310.45191495
115Butanoate metabolism_Homo sapiens_hsa006500.44954960
116Hematopoietic cell lineage_Homo sapiens_hsa046400.44568785
117Hepatitis C_Homo sapiens_hsa051600.43626779
118Pathways in cancer_Homo sapiens_hsa052000.43623938
119Malaria_Homo sapiens_hsa051440.42467413
120Ribosome_Homo sapiens_hsa030100.42238642
121Bile secretion_Homo sapiens_hsa049760.41862971
122B cell receptor signaling pathway_Homo sapiens_hsa046620.41488144
123Primary bile acid biosynthesis_Homo sapiens_hsa001200.41271296
124T cell receptor signaling pathway_Homo sapiens_hsa046600.39862055
125Tryptophan metabolism_Homo sapiens_hsa003800.39842157
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39501733
127Notch signaling pathway_Homo sapiens_hsa043300.36620763
128Hepatitis B_Homo sapiens_hsa051610.36325560
129HTLV-I infection_Homo sapiens_hsa051660.36198764
130Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35606418
131* Chemokine signaling pathway_Homo sapiens_hsa040620.33496640
132Pancreatic secretion_Homo sapiens_hsa049720.32972171
133Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.32387430
134RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31409307
135Chronic myeloid leukemia_Homo sapiens_hsa052200.30535764
136RNA polymerase_Homo sapiens_hsa030200.29008135
137Viral myocarditis_Homo sapiens_hsa054160.28191996
138VEGF signaling pathway_Homo sapiens_hsa043700.27502883
139Melanogenesis_Homo sapiens_hsa049160.26440156
140Fructose and mannose metabolism_Homo sapiens_hsa000510.25996469
141Vitamin digestion and absorption_Homo sapiens_hsa049770.25535136
142Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.25390323
143Type II diabetes mellitus_Homo sapiens_hsa049300.22242951
144Collecting duct acid secretion_Homo sapiens_hsa049660.19387648
145HIF-1 signaling pathway_Homo sapiens_hsa040660.15691668
146Linoleic acid metabolism_Homo sapiens_hsa005910.15471613
147Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.14331535
148Fat digestion and absorption_Homo sapiens_hsa049750.10873847

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »