CCL21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)7.74544286
2complement activation, classical pathway (GO:0006958)6.68754831
3regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.89290258
4complement activation (GO:0006956)5.44713944
5antigen processing and presentation of endogenous antigen (GO:0019883)5.19214379
6antimicrobial humoral response (GO:0019730)5.14682573
7response to nitric oxide (GO:0071731)5.14374064
8antibacterial humoral response (GO:0019731)5.13495199
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.08458988
10regulation of guanylate cyclase activity (GO:0031282)5.07445860
11positive regulation of Cdc42 GTPase activity (GO:0043089)5.06087011
12* regulation of dendritic cell antigen processing and presentation (GO:0002604)5.03805246
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.02691349
14positive regulation of respiratory burst (GO:0060267)5.02029677
15* regulation of cellular extravasation (GO:0002691)4.94457609
16NADH metabolic process (GO:0006734)4.83505197
17virion attachment to host cell (GO:0019062)4.52461578
18adhesion of symbiont to host cell (GO:0044650)4.52461578
19epoxygenase P450 pathway (GO:0019373)4.48375384
20glomerular filtration (GO:0003094)4.29841551
21intestinal absorption (GO:0050892)4.28849699
22fat-soluble vitamin biosynthetic process (GO:0042362)4.25111418
23peptide catabolic process (GO:0043171)4.23006100
24protein activation cascade (GO:0072376)4.22644436
25fructose metabolic process (GO:0006000)3.99948442
26* positive regulation of antigen processing and presentation (GO:0002579)3.95032642
27regulation of T-helper 1 cell differentiation (GO:0045625)3.90196414
28renal filtration (GO:0097205)3.87761106
29* regulation of antigen processing and presentation (GO:0002577)3.83400930
30adhesion of symbiont to host (GO:0044406)3.83282346
31regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.80291478
32endocrine process (GO:0050886)3.80291478
33regulation of systemic arterial blood pressure by hormone (GO:0001990)3.80291478
34hormone catabolic process (GO:0042447)3.70105430
35regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.63229365
36positive regulation of guanylate cyclase activity (GO:0031284)3.62796725
37regulation of respiratory burst (GO:0060263)3.59887986
38humoral immune response (GO:0006959)3.59837647
39low-density lipoprotein particle remodeling (GO:0034374)3.53079269
40diacylglycerol metabolic process (GO:0046339)3.50328022
41ethanol oxidation (GO:0006069)3.48733372
42regulation of systemic arterial blood pressure (GO:0003073)3.48137358
43immunoglobulin mediated immune response (GO:0016064)3.38188273
44phosphatidylserine acyl-chain remodeling (GO:0036150)3.37850877
45phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.34987192
46renal system process involved in regulation of blood volume (GO:0001977)3.34580037
47receptor guanylyl cyclase signaling pathway (GO:0007168)3.31940311
48lipoprotein transport (GO:0042953)3.27693458
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.27459756
50germinal center formation (GO:0002467)3.26350956
51drug metabolic process (GO:0017144)3.25685115
52positive regulation of lipoprotein lipase activity (GO:0051006)3.24656102
53positive regulation of triglyceride lipase activity (GO:0061365)3.24656102
54regulation of cGMP biosynthetic process (GO:0030826)3.23659500
55urea cycle (GO:0000050)3.21838755
56cellular response to nitric oxide (GO:0071732)3.18503542
57* positive regulation of glycoprotein biosynthetic process (GO:0010560)3.18129501
58cellular response to reactive nitrogen species (GO:1902170)3.16546519
59urea metabolic process (GO:0019627)3.10623875
60peptide hormone processing (GO:0016486)3.10557947
61endothelial cell chemotaxis (GO:0035767)3.07851804
62nitrogen cycle metabolic process (GO:0071941)3.06696312
63regulation of bile acid biosynthetic process (GO:0070857)3.06029725
64detection of bacterium (GO:0016045)3.04215155
65interferon-gamma-mediated signaling pathway (GO:0060333)3.02715445
66very-low-density lipoprotein particle assembly (GO:0034379)2.99926398
67* positive regulation of glycoprotein metabolic process (GO:1903020)2.97206128
68maintenance of gastrointestinal epithelium (GO:0030277)2.96864312
69sexual reproduction (GO:0019953)2.96578840
70phosphatidylinositol acyl-chain remodeling (GO:0036149)2.95433143
71regulation of integrin activation (GO:0033623)2.90667893
72protein-lipid complex remodeling (GO:0034368)2.89675421
73macromolecular complex remodeling (GO:0034367)2.89675421
74plasma lipoprotein particle remodeling (GO:0034369)2.89675421
75triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.88743791
76plasma lipoprotein particle assembly (GO:0034377)2.88092084
77* positive regulation of pseudopodium assembly (GO:0031274)2.86629010
78NIK/NF-kappaB signaling (GO:0038061)2.86031171
79regulation of vitamin metabolic process (GO:0030656)2.85955703
80phospholipid efflux (GO:0033700)2.84576973
81regulation of triglyceride catabolic process (GO:0010896)2.82438261
82* T cell costimulation (GO:0031295)2.78037962
83phospholipid scrambling (GO:0017121)2.77714020
84detection of other organism (GO:0098543)2.77345242
85actin filament depolymerization (GO:0030042)2.76722641
86lipoprotein metabolic process (GO:0042157)2.74691812
87* lymphocyte costimulation (GO:0031294)2.73693443
88cGMP-mediated signaling (GO:0019934)2.73654190
89lymph node development (GO:0048535)2.70163276
90regulation of cholesterol esterification (GO:0010872)2.69664348
91positive thymic T cell selection (GO:0045059)2.69254242
92protein-lipid complex assembly (GO:0065005)2.68696442
93plasma lipoprotein particle organization (GO:0071827)2.68469404
94leukotriene metabolic process (GO:0006691)2.65834393
95ethanol metabolic process (GO:0006067)2.62501953
96* dendritic cell chemotaxis (GO:0002407)2.61995292
97protein-lipid complex subunit organization (GO:0071825)2.59079216
98regulation of cGMP metabolic process (GO:0030823)2.58625693
99regulation of extracellular matrix disassembly (GO:0010715)2.58222039
100chronic inflammatory response (GO:0002544)2.58124586

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.61451904
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.40691749
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.93571528
4CDX2_20551321_ChIP-Seq_CACO-2_Human3.11201150
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.03056828
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.91573811
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.83129752
8RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.55290065
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.46034560
10LXR_22292898_ChIP-Seq_THP-1_Human2.30719589
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.24800840
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.09113045
13SOX2_27498859_Chip-Seq_STOMACH_Mouse2.04066498
14CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.03678035
15PPARA_22158963_ChIP-Seq_LIVER_Mouse2.03207316
16IRF8_21731497_ChIP-ChIP_J774_Mouse1.95718339
17TRIM28_21343339_ChIP-Seq_HEK293_Human1.90880445
18RARG_19884340_ChIP-ChIP_MEFs_Mouse1.81078714
19LXR_22158963_ChIP-Seq_LIVER_Mouse1.74480412
20GATA4_25053715_ChIP-Seq_YYC3_Human1.66752454
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.63345265
22CLOCK_20551151_ChIP-Seq_293T_Human1.63242069
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.61113554
24ELK3_25401928_ChIP-Seq_HUVEC_Human1.56949320
25VDR_24763502_ChIP-Seq_THP-1_Human1.55910763
26GATA6_25053715_ChIP-Seq_YYC3_Human1.55879617
27PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.52999752
28BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.52935491
29VDR_21846776_ChIP-Seq_THP-1_Human1.52578395
30RACK7_27058665_Chip-Seq_MCF-7_Human1.52219017
31NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.51037856
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47333179
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46943588
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44670305
35SOX2_20726797_ChIP-Seq_SW620_Human1.43718700
36TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41356065
37HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.40164046
38IRF8_27001747_Chip-Seq_BMDM_Mouse1.36488229
39BCL6_27268052_Chip-Seq_Bcells_Human1.36001453
40EGR1_23403033_ChIP-Seq_LIVER_Mouse1.34314416
41BCOR_27268052_Chip-Seq_Bcells_Human1.31129590
42TET1_21451524_ChIP-Seq_MESCs_Mouse1.29239865
43FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.28737340
44STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.28013778
45EGR1_19032775_ChIP-ChIP_M12_Human1.27720978
46DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26772641
47BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.25868804
48GATA1_22025678_ChIP-Seq_K562_Human1.23584617
49SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22914166
50SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22856265
51NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22619324
52SA1_27219007_Chip-Seq_Bcells_Human1.21529673
53KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20250301
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.20184721
55STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18860679
56RUNX_20019798_ChIP-Seq_JUKART_Human1.18513522
57CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17581989
58MYC_22102868_ChIP-Seq_BL_Human1.15733709
59TCF7_22412390_ChIP-Seq_EML_Mouse1.15127492
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14432790
61UTX_26944678_Chip-Seq_JUKART_Human1.14267601
62SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14116009
63CTCF_27219007_Chip-Seq_Bcells_Human1.12585555
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10458017
65SA1_27219007_Chip-Seq_ERYTHROID_Human1.09343300
66NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07660483
67P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07649085
68IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.07483338
69MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.07012087
70FOXO3_23340844_ChIP-Seq_DLD1_Human1.06847499
71ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06712308
72FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.05447903
73CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04356110
74SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03670075
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03193426
76MAF_26560356_Chip-Seq_TH1_Human1.00720200
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00550090
78CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00425543
79STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.99715750
80RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.99162851
81FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98724503
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98549643
83GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97845305
84RUNX1_22412390_ChIP-Seq_EML_Mouse0.97619851
85GATA1_19941826_ChIP-Seq_K562_Human0.96995377
86CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96450699
87GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95698632
88KDM2B_26808549_Chip-Seq_DND41_Human0.95208090
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95156878
90IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95118044
91ESR2_21235772_ChIP-Seq_MCF-7_Human0.95036718
92STAT1_20625510_ChIP-Seq_HELA_Human0.93134476
93RUNX1_27514584_Chip-Seq_MCF-7_Human0.92731087
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92669614
95FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.92661113
96MYB_26560356_Chip-Seq_TH1_Human0.92366523
97RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89139880
98JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.88971459
99CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.88622247
100CTCF_20526341_ChIP-Seq_ESCs_Human0.88372360

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.79702648
2MP0009379_abnormal_foot_pigmentation3.71428660
3MP0002139_abnormal_hepatobiliary_system3.48169925
4MP0010155_abnormal_intestine_physiology3.26490869
5MP0001666_abnormal_nutrient_absorption3.14779660
6MP0010234_abnormal_vibrissa_follicle2.96196842
7MP0009840_abnormal_foam_cell2.86633863
8MP0000685_abnormal_immune_system2.83875874
9MP0005085_abnormal_gallbladder_physiolo2.68705487
10MP0003183_abnormal_peptide_metabolism2.48670395
11MP0003724_increased_susceptibility_to2.46103930
12MP0005365_abnormal_bile_salt2.40943104
13MP0001873_stomach_inflammation2.40663684
14MP0001835_abnormal_antigen_presentation2.35098498
15MP0004264_abnormal_extraembryonic_tissu2.17979868
16MP0004019_abnormal_vitamin_homeostasis2.16292472
17MP0005387_immune_system_phenotype2.14424499
18MP0001790_abnormal_immune_system2.14424499
19MP0003866_abnormal_defecation2.14258019
20MP0005166_decreased_susceptibility_to2.10240836
21MP0002138_abnormal_hepatobiliary_system2.07677121
22MP0003436_decreased_susceptibility_to2.05529872
23MP0005409_darkened_coat_color1.89978620
24MP0003303_peritoneal_inflammation1.89722258
25MP0010352_gastrointestinal_tract_polyps1.77162599
26MP0004782_abnormal_surfactant_physiolog1.72543697
27MP0001800_abnormal_humoral_immune1.71942404
28MP0005025_abnormal_response_to1.69788833
29MP0005671_abnormal_response_to1.69527898
30MP0003191_abnormal_cellular_cholesterol1.68174454
31MP0004858_abnormal_nervous_system1.62966616
32MP0009785_altered_susceptibility_to1.62609160
33MP0000490_abnormal_crypts_of1.58163626
34MP0001663_abnormal_digestive_system1.55694632
35MP0001664_abnormal_digestion1.52252159
36MP0000465_gastrointestinal_hemorrhage1.47964880
37MP0005000_abnormal_immune_tolerance1.47362358
38MP0003300_gastrointestinal_ulcer1.46594948
39MP0002166_altered_tumor_susceptibility1.44098592
40MP0009643_abnormal_urine_homeostasis1.42632852
41MP0010329_abnormal_lipoprotein_level1.42410265
42MP0001845_abnormal_inflammatory_respons1.40348837
43MP0000477_abnormal_intestine_morphology1.36093503
44MP0002876_abnormal_thyroid_physiology1.35380369
45MP0000678_abnormal_parathyroid_gland1.34240276
46MP0001533_abnormal_skeleton_physiology1.28384656
47MP0005381_digestive/alimentary_phenotyp1.26808085
48MP0002452_abnormal_antigen_presenting1.23755266
49MP0002148_abnormal_hypersensitivity_rea1.23193572
50MP0005332_abnormal_amino_acid1.21461550
51MP0002796_impaired_skin_barrier1.18557079
52MP0002723_abnormal_immune_serum1.16557614
53MP0003868_abnormal_feces_composition1.16131098
54MP0004947_skin_inflammation1.16063769
55MP0008004_abnormal_stomach_pH1.15719383
56MP0003763_abnormal_thymus_physiology1.13795705
57MP0002136_abnormal_kidney_physiology1.12962233
58MP0002420_abnormal_adaptive_immunity1.12326377
59MP0001819_abnormal_immune_cell1.11324654
60MP0005275_abnormal_skin_tensile1.08295427
61MP0000604_amyloidosis1.08045068
62MP0004147_increased_porphyrin_level1.06747746
63MP0005058_abnormal_lysosome_morphology1.05395640
64MP0006082_CNS_inflammation1.04849597
65MP0002419_abnormal_innate_immunity1.04549500
66MP0009333_abnormal_splenocyte_physiolog1.03967460
67MP0004043_abnormal_pH_regulation1.02695773
68MP0000249_abnormal_blood_vessel1.01654437
69MP0000462_abnormal_digestive_system1.01294395
70MP0008469_abnormal_protein_level0.95932205
71MP0000681_abnormal_thyroid_gland0.95616608
72MP0001756_abnormal_urination0.95231080
73MP0003329_amyloid_beta_deposits0.95204022
74MP0000538_abnormal_urinary_bladder0.93067904
75MP0002998_abnormal_bone_remodeling0.92259617
76MP0001765_abnormal_ion_homeostasis0.90646231
77MP0001764_abnormal_homeostasis0.89332263
78MP0002254_reproductive_system_inflammat0.89272631
79MP0003252_abnormal_bile_duct0.87434605
80MP0000716_abnormal_immune_system0.86300755
81MP0002933_joint_inflammation0.85130151
82MP0002971_abnormal_brown_adipose0.84775744
83MP0005584_abnormal_enzyme/coenzyme_acti0.84656115
84MP0005451_abnormal_body_composition0.84602005
85MP0002118_abnormal_lipid_homeostasis0.83787920
86MP0005310_abnormal_salivary_gland0.83516047
87MP0003879_abnormal_hair_cell0.82750165
88MP0009764_decreased_sensitivity_to0.81515779
89MP0000609_abnormal_liver_physiology0.80379547
90MP0003075_altered_response_to0.79973897
91MP0002006_tumorigenesis0.78693143
92MP0004510_myositis0.77175978
93MP0001958_emphysema0.75612763
94MP0009115_abnormal_fat_cell0.72605840
95MP0005670_abnormal_white_adipose0.72444821
96MP0001501_abnormal_sleep_pattern0.72377493
97MP0005023_abnormal_wound_healing0.71737311
98MP0003448_altered_tumor_morphology0.71294727
99MP0005448_abnormal_energy_balance0.69712440
100MP0005535_abnormal_body_temperature0.69422346

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)7.85087831
2Abnormality of glutamine family amino acid metabolism (HP:0010902)6.79930955
3Malnutrition (HP:0004395)6.18878507
4Abnormality of complement system (HP:0005339)5.35631264
5Complement deficiency (HP:0004431)5.27369327
6Chronic diarrhea (HP:0002028)5.12644722
7Gastrointestinal stroma tumor (HP:0100723)4.95457012
8Glomerulonephritis (HP:0000099)4.77231372
9Abnormality of proline metabolism (HP:0010907)4.47972315
10Hydroxyprolinuria (HP:0003080)4.47972315
11Eczematoid dermatitis (HP:0000976)4.10953087
12Emphysema (HP:0002097)4.03355310
13Nephritis (HP:0000123)3.87217500
14Ileus (HP:0002595)3.28075989
15Vasculitis (HP:0002633)3.18807284
16Abnormality of monocarboxylic acid metabolism (HP:0010996)3.07881545
17Agammaglobulinemia (HP:0004432)2.99117320
18Recurrent bronchitis (HP:0002837)2.93779673
19Abnormality of the vitamin B12 metabolism (HP:0004341)2.85650149
20Abnormality of small intestinal villus morphology (HP:0011472)2.81678657
21Villous atrophy (HP:0011473)2.81678657
22Restrictive lung disease (HP:0002091)2.81546410
23Xanthomatosis (HP:0000991)2.79408250
24Decreased circulating renin level (HP:0003351)2.79217324
25Hypobetalipoproteinemia (HP:0003563)2.78327496
26Fat malabsorption (HP:0002630)2.77750599
27Hemorrhage of the eye (HP:0011885)2.63532675
28Abnormality of vitamin B metabolism (HP:0004340)2.63526159
29Widely patent fontanelles and sutures (HP:0004492)2.63449732
30Congenital sensorineural hearing impairment (HP:0008527)2.61784588
31Lymphopenia (HP:0001888)2.55425338
32Abnormality of the nasal mucosa (HP:0000433)2.54995638
33Abnormality of cells of the lymphoid lineage (HP:0012140)2.53381014
34Pustule (HP:0200039)2.50945932
35Cerebral palsy (HP:0100021)2.46481380
36Increased IgE level (HP:0003212)2.45905443
37Gingivitis (HP:0000230)2.45046246
38Meningitis (HP:0001287)2.41990384
39Colitis (HP:0002583)2.40964181
40Alkalosis (HP:0001948)2.36708825
41Spontaneous hematomas (HP:0007420)2.36545469
42Metabolic alkalosis (HP:0200114)2.32638494
43Thin bony cortex (HP:0002753)2.31624339
44Abnormal delayed hypersensitivity skin test (HP:0002963)2.31037098
45Hypophosphatemia (HP:0002148)2.30703775
46IgA deficiency (HP:0002720)2.29993613
47Nausea (HP:0002018)2.28866896
48Purpura (HP:0000979)2.23458383
49Skin rash (HP:0000988)2.23312050
50Confusion (HP:0001289)2.22093164
51Growth hormone excess (HP:0000845)2.21232893
52Cellulitis (HP:0100658)2.21104467
53Wide cranial sutures (HP:0010537)2.19883404
54Abnormality of vitamin metabolism (HP:0100508)2.18378356
55Chronic otitis media (HP:0000389)2.17320584
56Hyperparathyroidism (HP:0000843)2.16916043
57Premature loss of primary teeth (HP:0006323)2.16519671
58Abdominal distention (HP:0003270)2.14789903
59Potter facies (HP:0002009)2.12833199
60Facial shape deformation (HP:0011334)2.12833199
61Recurrent gram-negative bacterial infections (HP:0005420)2.11353249
62Chronic obstructive pulmonary disease (HP:0006510)2.10887210
63Obstructive lung disease (HP:0006536)2.10887210
64Inflammation of the large intestine (HP:0002037)2.09853075
65Posterior subcapsular cataract (HP:0007787)2.06928783
66Segmental peripheral demyelination/remyelination (HP:0003481)2.05545916
67Hemoptysis (HP:0002105)2.05363920
68Gastrointestinal inflammation (HP:0004386)2.03833055
69Osteomyelitis (HP:0002754)2.03062699
70Nephrolithiasis (HP:0000787)2.02569171
71Pulmonary infiltrates (HP:0002113)2.01449788
72Pigmentary retinal degeneration (HP:0001146)2.01271224
73Steatorrhea (HP:0002570)2.00304673
74Gastrointestinal dysmotility (HP:0002579)1.99639482
75Hyperactive renin-angiotensin system (HP:0000841)1.97209086
76Nasal polyposis (HP:0100582)1.97122774
77Panhypogammaglobulinemia (HP:0003139)1.95256000
78Abnormality of macrophages (HP:0004311)1.92607028
79Abnormality of renin-angiotensin system (HP:0000847)1.92048681
80Recurrent sinusitis (HP:0011108)1.90679358
81Pancreatitis (HP:0001733)1.88525843
82Hyperglycinuria (HP:0003108)1.86780573
83Abnormality of urine glucose concentration (HP:0011016)1.85148408
84Glycosuria (HP:0003076)1.85148408
85Hypotension (HP:0002615)1.84857640
86Acanthocytosis (HP:0001927)1.81621282
87Right ventricular cardiomyopathy (HP:0011663)1.81173345
88Rectal prolapse (HP:0002035)1.79077197
89Gastrointestinal infarctions (HP:0005244)1.78254511
90Hyperuricemia (HP:0002149)1.78163158
91Increased purine levels (HP:0004368)1.78163158
92Focal segmental glomerulosclerosis (HP:0000097)1.75744347
93Elevated erythrocyte sedimentation rate (HP:0003565)1.75462411
94Hyperlipoproteinemia (HP:0010980)1.74769291
95Verrucae (HP:0200043)1.72830329
96Papilloma (HP:0012740)1.72830329
97Abnormal glucose tolerance (HP:0001952)1.72465523
98Amyloidosis (HP:0011034)1.72123848
99Hyperphosphatemia (HP:0002905)1.71970676
100Encephalitis (HP:0002383)1.71106869

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN16.07682408
2ACVR1B3.54738976
3MAP4K13.51921158
4RIPK13.22869228
5FGFR43.13440011
6MST1R3.09273034
7TYK22.81554567
8EPHA32.33140656
9PRKG22.28826595
10MAP3K102.21599693
11EPHA21.95609884
12PRPF4B1.91369869
13EPHB11.79661339
14RIPK41.77241751
15EPHB21.72318993
16CDC42BPA1.71125939
17TRIB31.68563104
18JAK31.66495953
19MYLK1.59265756
20FGFR31.55514140
21TBK11.48383481
22IKBKE1.47677093
23PTK61.43863573
24GRK61.40512191
25ZAP701.40019706
26JAK11.35617409
27MAP3K11.34534333
28MAP3K141.33652527
29DDR21.29785150
30MAP2K21.24342853
31TESK11.23115722
32TESK21.22758060
33KIT1.19366919
34DMPK1.18297624
35BLK1.17101908
36NLK1.15903094
37MAP3K111.08723484
38TGFBR21.08281709
39BTK1.06602942
40CSF1R1.05341332
41CSK0.98676035
42MET0.96431998
43SYK0.92754429
44SMG10.90381130
45KDR0.88912047
46MAP3K130.87446181
47MATK0.83897159
48LRRK20.83391059
49JAK20.80091690
50FER0.80005220
51LYN0.78617901
52PDGFRA0.77507858
53STK240.76745906
54HIPK20.76320157
55PDPK10.72133394
56LCK0.71295680
57ITK0.70913429
58TAOK10.69225371
59SIK30.66656800
60STK390.65425274
61MAP3K20.64648954
62ERBB20.63103317
63SIK10.62684623
64TXK0.62414087
65MAP3K120.61415282
66MAPK70.60210169
67CDK190.59620003
68RET0.59611533
69BMX0.58546093
70PIK3CA0.57883000
71IRAK10.56775023
72FYN0.55958063
73FES0.55941325
74OXSR10.53905667
75MAPK110.53022181
76TEC0.52911229
77DYRK1B0.52763747
78PRKD20.50391927
79IRAK40.49441472
80TNK20.49165213
81PDK10.48938615
82IKBKB0.48253749
83MAP3K30.46922767
84SRC0.46916792
85MAPKAPK20.44620071
86HCK0.43341287
87PRKACG0.41717981
88RPS6KA20.41328033
89PRKAA20.41103772
90RPS6KL10.37800363
91RPS6KC10.37800363
92MAP3K70.35890877
93PRKCQ0.35675116
94PKN20.33654172
95PRKCA0.32389561
96PRKCZ0.32211141
97MAP2K60.32148770
98MAPK40.32004260
99PAK40.31579229
100CDK60.31519818

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.02896746
2Fat digestion and absorption_Homo sapiens_hsa049753.55088518
3Asthma_Homo sapiens_hsa053103.43030738
4Renin-angiotensin system_Homo sapiens_hsa046143.00024359
5Staphylococcus aureus infection_Homo sapiens_hsa051502.99932341
6Autoimmune thyroid disease_Homo sapiens_hsa053202.92611131
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.89808770
8Allograft rejection_Homo sapiens_hsa053302.87206793
9Graft-versus-host disease_Homo sapiens_hsa053322.62689012
10Vitamin digestion and absorption_Homo sapiens_hsa049772.48391630
11Type I diabetes mellitus_Homo sapiens_hsa049402.17263189
12Histidine metabolism_Homo sapiens_hsa003402.03274541
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.98292700
14Linoleic acid metabolism_Homo sapiens_hsa005911.97030206
15Arginine biosynthesis_Homo sapiens_hsa002201.96900003
16Antigen processing and presentation_Homo sapiens_hsa046121.81361857
17Mineral absorption_Homo sapiens_hsa049781.77233345
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.77162633
19Protein digestion and absorption_Homo sapiens_hsa049741.72882012
20Fructose and mannose metabolism_Homo sapiens_hsa000511.66918036
21Leishmaniasis_Homo sapiens_hsa051401.61197386
22Arachidonic acid metabolism_Homo sapiens_hsa005901.61194687
23Viral myocarditis_Homo sapiens_hsa054161.55206337
24Primary immunodeficiency_Homo sapiens_hsa053401.37274328
25Complement and coagulation cascades_Homo sapiens_hsa046101.34215883
26Sulfur metabolism_Homo sapiens_hsa009201.23752696
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.23419142
28Caffeine metabolism_Homo sapiens_hsa002321.21776826
29Carbohydrate digestion and absorption_Homo sapiens_hsa049731.19327123
30PPAR signaling pathway_Homo sapiens_hsa033201.19137880
31Pertussis_Homo sapiens_hsa051331.18900798
32Chemical carcinogenesis_Homo sapiens_hsa052041.17448353
33Other glycan degradation_Homo sapiens_hsa005111.16901960
34Retinol metabolism_Homo sapiens_hsa008301.15498832
35Hematopoietic cell lineage_Homo sapiens_hsa046401.11581886
36Ether lipid metabolism_Homo sapiens_hsa005651.10124235
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08083617
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.06639230
39Fatty acid degradation_Homo sapiens_hsa000711.05913513
40Starch and sucrose metabolism_Homo sapiens_hsa005001.03766228
41Glycerolipid metabolism_Homo sapiens_hsa005611.03431981
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03392162
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.01295174
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01182910
45Arginine and proline metabolism_Homo sapiens_hsa003301.00343099
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.99822132
47Toxoplasmosis_Homo sapiens_hsa051450.98989533
48Galactose metabolism_Homo sapiens_hsa000520.92216436
49Bile secretion_Homo sapiens_hsa049760.87235782
50B cell receptor signaling pathway_Homo sapiens_hsa046620.86233197
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86121583
52Rheumatoid arthritis_Homo sapiens_hsa053230.85740642
53Tryptophan metabolism_Homo sapiens_hsa003800.85031635
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.83731153
55Pancreatic secretion_Homo sapiens_hsa049720.77380251
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73229521
57Influenza A_Homo sapiens_hsa051640.72695247
58Tuberculosis_Homo sapiens_hsa051520.72336103
59Phenylalanine metabolism_Homo sapiens_hsa003600.71922631
60* NF-kappa B signaling pathway_Homo sapiens_hsa040640.69012886
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.67096957
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.65307055
63Herpes simplex infection_Homo sapiens_hsa051680.64687892
64Glutathione metabolism_Homo sapiens_hsa004800.63772574
65Prion diseases_Homo sapiens_hsa050200.62643901
66* Chemokine signaling pathway_Homo sapiens_hsa040620.61562882
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.60619977
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55119932
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54275631
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.52692847
71Phagosome_Homo sapiens_hsa041450.52072071
72Hepatitis C_Homo sapiens_hsa051600.50966076
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.50154334
74Thyroid hormone synthesis_Homo sapiens_hsa049180.47016294
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.42836864
76Tyrosine metabolism_Homo sapiens_hsa003500.42745954
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41064390
78Osteoclast differentiation_Homo sapiens_hsa043800.40607865
79* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38729553
80Systemic lupus erythematosus_Homo sapiens_hsa053220.37969852
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.36154766
82TNF signaling pathway_Homo sapiens_hsa046680.34727557
83African trypanosomiasis_Homo sapiens_hsa051430.34232854
84Renin secretion_Homo sapiens_hsa049240.32692597
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31610605
86Insulin resistance_Homo sapiens_hsa049310.30589373
87Amoebiasis_Homo sapiens_hsa051460.28206692
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.25125594
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.23679689
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22935415
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.20192451
92Sphingolipid metabolism_Homo sapiens_hsa006000.17597004
93GnRH signaling pathway_Homo sapiens_hsa049120.13397117
94Pentose phosphate pathway_Homo sapiens_hsa000300.12317817
95Lysosome_Homo sapiens_hsa041420.12311475
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.12247712
97Salmonella infection_Homo sapiens_hsa051320.11640553
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.11108544
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.10020655
100Toll-like receptor signaling pathway_Homo sapiens_hsa046200.08466836

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