CCL22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of T-helper 1 cell differentiation (GO:0045625)7.66042541
2regulation of activation of Janus kinase activity (GO:0010533)7.36695742
3growth hormone receptor signaling pathway (GO:0060396)7.08133708
4positive regulation of T-helper cell differentiation (GO:0045624)6.66308159
5regulation of T-helper 2 cell differentiation (GO:0045628)6.22443504
6cellular response to growth hormone stimulus (GO:0071378)6.09953930
7T-helper 1 type immune response (GO:0042088)6.08818729
8regulation of memory T cell differentiation (GO:0043380)6.01881109
9CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)5.86890317
10positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)5.62860083
11positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)5.59595045
12positive regulation of alpha-beta T cell proliferation (GO:0046641)5.47988734
13positive regulation of interleukin-12 production (GO:0032735)5.45707672
14positive regulation of natural killer cell differentiation (GO:0032825)5.45147770
15positive regulation of type 2 immune response (GO:0002830)5.41328155
16regulation of dendritic cell antigen processing and presentation (GO:0002604)5.38245513
17regulation of T-helper cell differentiation (GO:0045622)5.28801141
18immunoglobulin mediated immune response (GO:0016064)5.07698029
19positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.06280245
20regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)5.00252369
21negative regulation of inflammatory response to antigenic stimulus (GO:0002862)4.98935391
22regulation of alpha-beta T cell proliferation (GO:0046640)4.93627952
23antigen processing and presentation of endogenous antigen (GO:0019883)4.90106288
24regulation of immunoglobulin secretion (GO:0051023)4.88383112
25regulation of B cell receptor signaling pathway (GO:0050855)4.83449701
26positive regulation of gamma-delta T cell activation (GO:0046645)4.82980737
27regulation of hypersensitivity (GO:0002883)4.82691761
28negative regulation of interleukin-17 production (GO:0032700)4.79356927
29NIK/NF-kappaB signaling (GO:0038061)4.77162651
30positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)4.73357242
31B cell receptor signaling pathway (GO:0050853)4.60368589
32myeloid dendritic cell differentiation (GO:0043011)4.56332454
33regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)4.52410690
34modulation by symbiont of host immune response (GO:0052553)4.49102285
35positive regulation by symbiont of host defense response (GO:0052509)4.49102285
36modulation by symbiont of host defense response (GO:0052031)4.49102285
37modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.49102285
38modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.49102285
39positive regulation by organism of defense response of other organism involved in symbiotic interact4.49102285
40neutrophil activation involved in immune response (GO:0002283)4.44835446
41negative thymic T cell selection (GO:0045060)4.44458006
42antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.44185010
43antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.44185010
44positive regulation of activated T cell proliferation (GO:0042104)4.43454510
45positive regulation of antigen processing and presentation (GO:0002579)4.40694991
46regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.38149769
47regulation of T-helper 1 type immune response (GO:0002825)4.34877492
48B cell homeostasis (GO:0001782)4.32515380
49regulation of response to tumor cell (GO:0002834)4.28559955
50positive regulation of immune response to tumor cell (GO:0002839)4.28559955
51natural killer cell mediated immunity (GO:0002228)4.24373710
52natural killer cell mediated cytotoxicity (GO:0042267)4.24373710
53positive regulation of macrophage cytokine production (GO:0060907)4.24243415
54B cell mediated immunity (GO:0019724)4.24029186
55neutrophil activation (GO:0042119)4.23042161
56T cell lineage commitment (GO:0002360)4.16752641
57type I interferon signaling pathway (GO:0060337)4.14691204
58cellular response to type I interferon (GO:0071357)4.14691204
59response to protozoan (GO:0001562)4.13144567
60granulocyte activation (GO:0036230)4.13133426
61positive regulation of T cell cytokine production (GO:0002726)4.12905886
62positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.11490939
63negative T cell selection (GO:0043383)4.10490756
64positive regulation of interleukin-2 production (GO:0032743)4.10256608
65cellular response to zinc ion (GO:0071294)4.08896295
66positive regulation of interleukin-17 production (GO:0032740)4.08741058
67response to type I interferon (GO:0034340)4.06211307
68regulation of interleukin-12 production (GO:0032655)4.06059268
69regulation of T cell tolerance induction (GO:0002664)4.03421770
70positive regulation of inflammatory response to antigenic stimulus (GO:0002863)4.03373184
71myeloid dendritic cell activation (GO:0001773)4.02824969
72regulation of RIG-I signaling pathway (GO:0039535)4.01658981
73T cell migration (GO:0072678)3.98460482
74regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.97013477
75T cell costimulation (GO:0031295)3.90616979
76response to prostaglandin E (GO:0034695)3.87984547
77natural killer cell differentiation (GO:0001779)3.87540540
78positive regulation of T-helper 1 type immune response (GO:0002827)3.86016014
79regulation of antigen processing and presentation (GO:0002577)3.86013986
80lymphocyte costimulation (GO:0031294)3.85018412
81regulation of interleukin-17 production (GO:0032660)3.81514038
82cellular response to interferon-gamma (GO:0071346)3.74800706
83positive regulation of interferon-alpha production (GO:0032727)3.71950807
84positive regulation of humoral immune response (GO:0002922)3.71590414
85antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.70904604
86dendritic cell differentiation (GO:0097028)3.70268429
87JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.68869392
88detection of bacterium (GO:0016045)3.63555068
89regulation of interleukin-12 biosynthetic process (GO:0045075)3.62636010
90regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.60260365
91positive regulation of B cell differentiation (GO:0045579)3.60048931
92regulation of interferon-beta biosynthetic process (GO:0045357)3.59577801
93positive regulation of cytokine biosynthetic process (GO:0042108)3.58656547
94B cell proliferation (GO:0042100)3.57517209
95positive regulation of immunoglobulin mediated immune response (GO:0002891)3.56105336
96positive regulation of B cell mediated immunity (GO:0002714)3.56105336
97natural killer cell activation (GO:0030101)3.51201104
98regulation of inflammatory response to antigenic stimulus (GO:0002861)3.50995113
99cytidine metabolic process (GO:0046087)3.49944139
100cytidine catabolic process (GO:0006216)3.49944139
101cytidine deamination (GO:0009972)3.49944139
102interferon-gamma-mediated signaling pathway (GO:0060333)3.48520285
103positive regulation of alpha-beta T cell differentiation (GO:0046638)3.47634672
104positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.47182357
105regulation of interferon-alpha production (GO:0032647)3.47011911
106monocyte chemotaxis (GO:0002548)3.46667078
107eosinophil chemotaxis (GO:0048245)3.45896314
108regulation of gamma-delta T cell activation (GO:0046643)3.44847942
109positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.44844217
110regulation of natural killer cell differentiation (GO:0032823)3.44696801
111thymic T cell selection (GO:0045061)3.41196425
112response to muramyl dipeptide (GO:0032495)3.40921099
113negative regulation of viral genome replication (GO:0045071)3.37648894
114regulation of interleukin-2 biosynthetic process (GO:0045076)3.36878417
115dendritic cell chemotaxis (GO:0002407)3.36323861
116T-helper cell differentiation (GO:0042093)3.34149678
117CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.34149678
118positive regulation of defense response to virus by host (GO:0002230)3.33313961
119regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.32876000
120regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.32177234
121detection of other organism (GO:0098543)3.30472887
122cellular extravasation (GO:0045123)3.30190135
123positive regulation of protein homooligomerization (GO:0032464)3.30016620
124regulation of interferon-gamma biosynthetic process (GO:0045072)3.29999667
125positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.29091743
126positive regulation of natural killer cell activation (GO:0032816)3.29073737
127regulation of tolerance induction (GO:0002643)3.28427209
128response to interferon-gamma (GO:0034341)3.27130936
129positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.25012454
130positive regulation of T cell proliferation (GO:0042102)3.24673661
131regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.23947651
132adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli3.21425526
133positive regulation of interleukin-10 production (GO:0032733)3.21118935
134regulation of activated T cell proliferation (GO:0046006)3.19845466
135regulation of B cell proliferation (GO:0030888)3.19685409
136defense response to protozoan (GO:0042832)3.18532948
137negative regulation of T-helper cell differentiation (GO:0045623)3.17805327
138negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.17805327
139positive regulation of monocyte chemotaxis (GO:0090026)3.17677103
140positive regulation of pseudopodium assembly (GO:0031274)3.17593137
141response to peptidoglycan (GO:0032494)3.17245011
142regulation of interleukin-10 production (GO:0032653)3.16882362
143response to growth hormone (GO:0060416)3.16664797
144regulation of alpha-beta T cell differentiation (GO:0046637)3.13238209
145positive regulation of interferon-gamma production (GO:0032729)3.12451615
146positive regulation of isotype switching (GO:0045830)3.12265359
147regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.11669619
148leukocyte mediated cytotoxicity (GO:0001909)3.10741588
149positive regulation of B cell proliferation (GO:0030890)3.10347442
150regulation of immune response to tumor cell (GO:0002837)3.08866233
151positive regulation of response to tumor cell (GO:0002836)3.08866233

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human8.17592083
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.47676307
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human6.34234081
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.25181723
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.00826531
6MYC_22102868_ChIP-Seq_BL_Human4.29460252
7* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.83757557
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.78844337
9TP63_17297297_ChIP-ChIP_HaCaT_Human3.65250286
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.60821143
11NOTCH1_21737748_ChIP-Seq_TLL_Human3.29275007
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.18086059
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.17450684
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.04236912
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.97643938
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.88538893
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.70983491
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.60445791
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.51848801
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.43209862
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.39793483
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.36559165
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.31599328
24CIITA_25753668_ChIP-Seq_RAJI_Human2.26222579
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.98338744
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.90826152
27* VDR_24787735_ChIP-Seq_THP-1_Human1.88201462
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.85633194
29MAF_26560356_Chip-Seq_TH1_Human1.85381283
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.83325391
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.81483884
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.79689534
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.75745798
34SCL_19346495_ChIP-Seq_HPC-7_Human1.73827230
35MYB_26560356_Chip-Seq_TH2_Human1.71902986
36RUNX_20019798_ChIP-Seq_JUKART_Human1.70916488
37BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.67335690
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56456929
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54055392
40SPI1_23547873_ChIP-Seq_NB4_Human1.53210856
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.50813910
42MYB_26560356_Chip-Seq_TH1_Human1.47686438
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.43995016
44PU_27001747_Chip-Seq_BMDM_Mouse1.38058985
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36338549
46FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.34067309
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31195148
48PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28887535
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28195568
50LXR_22292898_ChIP-Seq_THP-1_Human1.27371419
51GATA3_26560356_Chip-Seq_TH2_Human1.26964697
52PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26292760
53ZNF263_19887448_ChIP-Seq_K562_Human1.24715582
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20263246
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19713245
56* GATA3_27048872_Chip-Seq_THYMUS_Human1.19245543
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18948658
58* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18447636
59VDR_24763502_ChIP-Seq_THP-1_Human1.17900858
60EGR1_19032775_ChIP-ChIP_M12_Human1.15527010
61PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14987671
62SPI1_23127762_ChIP-Seq_K562_Human1.12900401
63CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08463886
64ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07947635
65E2F4_17652178_ChIP-ChIP_JURKAT_Human1.06935107
66TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06429647
67GATA1_22025678_ChIP-Seq_K562_Human1.05128412
68TFEB_21752829_ChIP-Seq_HELA_Human1.04556863
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03258053
70CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01848639
71PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01041579
72MAF_26560356_Chip-Seq_TH2_Human1.00246149
73SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99049479
74ELF1_20517297_ChIP-Seq_JURKAT_Human0.97420543
75VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95165744
76IRF1_19129219_ChIP-ChIP_H3396_Human0.95054226
77GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94878349
78SMRT_27268052_Chip-Seq_Bcells_Human0.92789604
79VDR_21846776_ChIP-Seq_THP-1_Human0.92760009
80CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92658366
81RUNX1_22412390_ChIP-Seq_EML_Mouse0.92473068
82BCL6_27268052_Chip-Seq_Bcells_Human0.91530542
83HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90804891
84VDR_23849224_ChIP-Seq_CD4+_Human0.87304039
85HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87052713
86NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86719335
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86719335
88GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.86289040
89NCOR1_26117541_ChIP-Seq_K562_Human0.83716102
90ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.83328794
91LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.80335515
92LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.80324908
93SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79965030
94GATA2_21666600_ChIP-Seq_HMVEC_Human0.79577410
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79158521
96SOX2_20726797_ChIP-Seq_SW620_Human0.78995814
97CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.77907440
98SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.77294977
99SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.77294977
100CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.76712554
101NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.75438892
102ELK3_25401928_ChIP-Seq_HUVEC_Human0.75393736
103FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74488011
104EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.73626741
105GATA1_19941827_ChIP-Seq_MEL_Mouse0.71893532
106TCF7_22412390_ChIP-Seq_EML_Mouse0.70292289
107PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.68713684
108RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.68607491
109CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.67791662
110EGR1_23403033_ChIP-Seq_LIVER_Mouse0.65979373
111FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.65946318
112E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.65063311
113IKZF1_21737484_ChIP-ChIP_HCT116_Human0.64021117
114KDM2B_26808549_Chip-Seq_DND41_Human0.63278563
115* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.63180855
116TP53_18474530_ChIP-ChIP_U2OS_Human0.62632376
117FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.61055238
118ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.60569119
119PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.60367376
120UTX_26944678_Chip-Seq_JUKART_Human0.59760030
121GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.59486085
122JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.58682924
123IGF1R_20145208_ChIP-Seq_DFB_Human0.58284179
124RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.57182184
125MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.56587673
126GATA2_22383799_ChIP-Seq_G1ME_Mouse0.56021342
127JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.55991810
128SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.54311679
129KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.53051918
130SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.53035925
131TP63_23658742_ChIP-Seq_EP156T_Human0.52329371
132PU1_27457419_Chip-Seq_LIVER_Mouse0.52172598
133CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.51645188
134STAT1_20625510_ChIP-Seq_HELA_Human0.51416861
135NMYC_18555785_Chip-Seq_ESCs_Mouse0.50538606

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system6.41655332
2MP0001348_abnormal_lacrimal_gland5.25250043
3MP0001835_abnormal_antigen_presentation5.03336473
4MP0002163_abnormal_gland_morphology4.88475494
5MP0000685_abnormal_immune_system4.67108204
6MP0002148_abnormal_hypersensitivity_rea4.15390664
7MP0001346_abnormal_lacrimal_gland3.81733948
8MP0005671_abnormal_response_to3.63199690
9MP0009785_altered_susceptibility_to3.47095930
10MP0001790_abnormal_immune_system3.36300156
11MP0005387_immune_system_phenotype3.36300156
12MP0003436_decreased_susceptibility_to2.81101186
13MP0005379_endocrine/exocrine_gland_phen2.80267500
14MP0005000_abnormal_immune_tolerance2.75582377
15MP0002166_altered_tumor_susceptibility2.74089837
16MP0002006_tumorigenesis2.55422910
17MP0005645_abnormal_hypothalamus_physiol2.55170666
18MP0004510_myositis2.50355042
19MP0005025_abnormal_response_to2.41230473
20MP0005310_abnormal_salivary_gland2.33489914
21MP0001800_abnormal_humoral_immune2.27196380
22MP0002723_abnormal_immune_serum2.23887229
23MP0002452_abnormal_antigen_presenting2.22424843
24MP0002419_abnormal_innate_immunity2.11068969
25MP0006082_CNS_inflammation2.10518424
26MP0002009_preneoplasia2.06851973
27MP0003303_peritoneal_inflammation2.05974673
28MP0001819_abnormal_immune_cell2.02188756
29MP0002420_abnormal_adaptive_immunity1.95276688
30MP0003724_increased_susceptibility_to1.72051688
31MP0002254_reproductive_system_inflammat1.59343303
32MP0001853_heart_inflammation1.54325257
33MP0000716_abnormal_immune_system1.52336899
34MP0005451_abnormal_body_composition1.46613706
35MP0009764_decreased_sensitivity_to1.45984613
36MP0005076_abnormal_cell_differentiation1.43458902
37MP0002398_abnormal_bone_marrow1.41932073
38MP0005623_abnormal_meninges_morphology1.37381443
39MP0002405_respiratory_system_inflammati1.33784094
40MP0001845_abnormal_inflammatory_respons1.32998684
41MP0002139_abnormal_hepatobiliary_system1.31841579
42MP0001727_abnormal_embryo_implantation1.31332084
43MP0000613_abnormal_salivary_gland1.30079575
44MP0008469_abnormal_protein_level1.26521592
45MP0010155_abnormal_intestine_physiology1.24699733
46MP0003172_abnormal_lysosome_physiology1.24076886
47MP0001533_abnormal_skeleton_physiology1.20010496
48MP0004947_skin_inflammation1.18894196
49MP0002277_abnormal_respiratory_mucosa1.17953311
50MP0002876_abnormal_thyroid_physiology1.16678877
51MP0003763_abnormal_thymus_physiology1.16586998
52MP0003448_altered_tumor_morphology1.13352421
53MP0003045_fibrosis1.12313987
54MP0003091_abnormal_cell_migration1.11938196
55MP0002429_abnormal_blood_cell1.10743683
56MP0005647_abnormal_sex_gland1.04575711
57MP0000371_diluted_coat_color1.03583369
58MP0005464_abnormal_platelet_physiology1.01607394
59MP0010094_abnormal_chromosome_stability0.94591262
60MP0008874_decreased_physiological_sensi0.91510784
61MP0008057_abnormal_DNA_replication0.91493966
62MP0002722_abnormal_immune_system0.89538078
63MP0003191_abnormal_cellular_cholesterol0.88334398
64MP0000689_abnormal_spleen_morphology0.86801697
65MP0001881_abnormal_mammary_gland0.86057662
66MP0000858_altered_metastatic_potential0.85898053
67MP0000343_altered_response_to0.85081972
68MP0005397_hematopoietic_system_phenotyp0.83252175
69MP0001545_abnormal_hematopoietic_system0.83252175
70MP0002877_abnormal_melanocyte_morpholog0.82644539
71MP0005166_decreased_susceptibility_to0.80960478
72MP0009840_abnormal_foam_cell0.80376590
73MP0009333_abnormal_splenocyte_physiolog0.78426833
74MP0002396_abnormal_hematopoietic_system0.74166439
75MP0000372_irregular_coat_pigmentation0.73224796
76MP0002998_abnormal_bone_remodeling0.71273582
77MP0009763_increased_sensitivity_to0.71046251
78MP0009115_abnormal_fat_cell0.69432190
79MP0000015_abnormal_ear_pigmentation0.69257134
80MP0000627_abnormal_mammary_gland0.67876978
81MP0003075_altered_response_to0.67322792
82MP0003300_gastrointestinal_ulcer0.67069419
83MP0003453_abnormal_keratinocyte_physiol0.67017715
84MP0000604_amyloidosis0.65306883
85MP0008872_abnormal_physiological_respon0.65158295
86MP0009046_muscle_twitch0.64273139
87MP0000249_abnormal_blood_vessel0.62988840
88MP0000490_abnormal_crypts_of0.60307390
89MP0002693_abnormal_pancreas_physiology0.59041236
90MP0003566_abnormal_cell_adhesion0.58207755
91MP0003183_abnormal_peptide_metabolism0.57313388
92MP0002136_abnormal_kidney_physiology0.56076493
93MP0000609_abnormal_liver_physiology0.55753815
94MP0005084_abnormal_gallbladder_morpholo0.55741798
95MP0004782_abnormal_surfactant_physiolog0.55486366
96MP0003186_abnormal_redox_activity0.55272843
97MP0000569_abnormal_digit_pigmentation0.55174540
98MP0000313_abnormal_cell_death0.55163113
99MP0005058_abnormal_lysosome_morphology0.54031696
100MP0001879_abnormal_lymphatic_vessel0.52755158
101MP0003866_abnormal_defecation0.52673252
102MP0009765_abnormal_xenobiotic_induced0.52016777
103MP0003943_abnormal_hepatobiliary_system0.51406962
104MP0000703_abnormal_thymus_morphology0.50878991
105MP0003656_abnormal_erythrocyte_physiolo0.49870427
106MP0003111_abnormal_nucleus_morphology0.48087445
107MP0003077_abnormal_cell_cycle0.47057978
108MP0005584_abnormal_enzyme/coenzyme_acti0.45783756
109MP0004381_abnormal_hair_follicle0.45770601
110MP0010386_abnormal_urinary_bladder0.45447716
111MP0005075_abnormal_melanosome_morpholog0.45197149
112MP0004742_abnormal_vestibular_system0.44726873
113MP0003941_abnormal_skin_development0.44530195
114MP0008004_abnormal_stomach_pH0.44295365
115MP0001873_stomach_inflammation0.42501270
116MP0005167_abnormal_blood-brain_barrier0.42279339
117MP0010307_abnormal_tumor_latency0.41513200
118MP0005390_skeleton_phenotype0.41465736
119MP0001243_abnormal_dermal_layer0.40434244
120MP0001915_intracranial_hemorrhage0.40336276
121MP0004185_abnormal_adipocyte_glucose0.39789387
122MP0003252_abnormal_bile_duct0.39774143
123MP0002933_joint_inflammation0.39654691
124MP0003828_pulmonary_edema0.38967232
125MP0002019_abnormal_tumor_incidence0.37642151
126MP0005423_abnormal_somatic_nervous0.35804699
127MP0009379_abnormal_foot_pigmentation0.35739216
128MP0010352_gastrointestinal_tract_polyps0.35280070
129MP0002928_abnormal_bile_duct0.34785681
130MP0004808_abnormal_hematopoietic_stem0.33956809

Predicted human phenotypes

RankGene SetZ-score
1Increased IgM level (HP:0003496)8.85750394
2Gastrointestinal stroma tumor (HP:0100723)7.62760767
3Autoimmune thrombocytopenia (HP:0001973)7.23693213
4Recurrent sinusitis (HP:0011108)6.01589365
5Eczematoid dermatitis (HP:0000976)5.76809321
6Gastrointestinal infarctions (HP:0005244)5.44923958
7Recurrent bacterial skin infections (HP:0005406)5.28140167
8Recurrent abscess formation (HP:0002722)4.91320365
9Optic neuritis (HP:0100653)4.90747776
10Retrobulbar optic neuritis (HP:0100654)4.90747776
11Chronic otitis media (HP:0000389)4.72160706
12Vasculitis (HP:0002633)4.69428244
13Vacuolated lymphocytes (HP:0001922)4.67682936
14Hypergammaglobulinemia (HP:0010702)4.62349130
15Lymphopenia (HP:0001888)4.52415577
16Orchitis (HP:0100796)4.46722887
17Recurrent gram-negative bacterial infections (HP:0005420)4.37904758
18Abnormal delayed hypersensitivity skin test (HP:0002963)4.35130980
19Elevated erythrocyte sedimentation rate (HP:0003565)4.31104114
20Recurrent fungal infections (HP:0002841)4.17115334
21Myositis (HP:0100614)4.16541206
22IgM deficiency (HP:0002850)4.11557388
23Abnormality of macrophages (HP:0004311)4.10362175
24Panhypogammaglobulinemia (HP:0003139)4.07403962
25Autoimmune hemolytic anemia (HP:0001890)4.05775999
26Tetraparesis (HP:0002273)4.05467334
27Emphysema (HP:0002097)4.03683244
28Mediastinal lymphadenopathy (HP:0100721)3.91879027
29Abnormality of T cell number (HP:0011839)3.78549004
30Restrictive lung disease (HP:0002091)3.77846934
31Recurrent viral infections (HP:0004429)3.75884309
32Eosinophilia (HP:0001880)3.64144342
33Chronic diarrhea (HP:0002028)3.62986751
34Hypochromic anemia (HP:0001931)3.54483391
35Basal ganglia calcification (HP:0002135)3.52751119
36Recurrent skin infections (HP:0001581)3.34969136
37Arterial thrombosis (HP:0004420)3.19705445
38Stomatitis (HP:0010280)3.17169589
39Granulocytopenia (HP:0001913)3.11985174
40Porencephaly (HP:0002132)3.11653470
41Leukocytosis (HP:0001974)3.10928569
42Nasal polyposis (HP:0100582)3.10102376
43Abnormality of eosinophils (HP:0001879)3.04359817
44Gastrointestinal inflammation (HP:0004386)2.94107000
45Fatigue (HP:0012378)2.93531522
46Urticaria (HP:0001025)2.92391603
47Thrombocytosis (HP:0001894)2.92289826
48Joint swelling (HP:0001386)2.91683685
49Pulmonary infiltrates (HP:0002113)2.91451640
50Viral hepatitis (HP:0006562)2.91018930
51Xerostomia (HP:0000217)2.90106578
52Abnormality of the prostate (HP:0008775)2.88207681
53Abnormality of T cell physiology (HP:0011840)2.85196582
54Leukopenia (HP:0001882)2.83875615
55Abnormality of proline metabolism (HP:0010907)2.81993609
56Hydroxyprolinuria (HP:0003080)2.81993609
57IgA deficiency (HP:0002720)2.79952166
58Keratoconjunctivitis sicca (HP:0001097)2.77301258
59Hemoptysis (HP:0002105)2.75530228
60Chronic sinusitis (HP:0011109)2.74276331
61Amaurosis fugax (HP:0100576)2.73096815
62Myocardial infarction (HP:0001658)2.72636939
63Gingival bleeding (HP:0000225)2.72127977
64Gingivitis (HP:0000230)2.70721335
65Verrucae (HP:0200043)2.70616340
66Papilloma (HP:0012740)2.70616340
67Chest pain (HP:0100749)2.69632065
68Peritonitis (HP:0002586)2.68206259
69Cellulitis (HP:0100658)2.66752207
70Vertebral compression fractures (HP:0002953)2.66746522
71Recurrent bronchitis (HP:0002837)2.66005353
72Chronic obstructive pulmonary disease (HP:0006510)2.65037302
73Obstructive lung disease (HP:0006536)2.65037302
74Agammaglobulinemia (HP:0004432)2.64939006
75Abnormality of liposaccharide metabolism (HP:0010968)2.62212051
76Abnormality of glycosphingolipid metabolism (HP:0004343)2.62212051
77Abnormality of glycolipid metabolism (HP:0010969)2.62212051
78Exertional dyspnea (HP:0002875)2.59878474
79Periodontitis (HP:0000704)2.59510939
80Meningitis (HP:0001287)2.59462270
81Abnormality of the nasal mucosa (HP:0000433)2.57455773
82Abnormality of T cells (HP:0002843)2.56905596
83Lymphoma (HP:0002665)2.54843004
84Keratoconjunctivitis (HP:0001096)2.53916699
85B lymphocytopenia (HP:0010976)2.52724953
86Chronic mucocutaneous candidiasis (HP:0002728)2.52469407
87Recurrent cutaneous fungal infections (HP:0011370)2.52469407
88Cerebral hemorrhage (HP:0001342)2.51971152
89Increased IgE level (HP:0003212)2.45644011
90Gangrene (HP:0100758)2.45538325
91Anorexia (HP:0002039)2.44053438
92Interstitial pulmonary disease (HP:0006530)2.43757798
93Polycythemia (HP:0001901)2.42033672
94Basal cell carcinoma (HP:0002671)2.41592845
95Encephalitis (HP:0002383)2.41521652
96Systemic lupus erythematosus (HP:0002725)2.41311446
97Abnormality of cells of the lymphoid lineage (HP:0012140)2.39290285
98Hypertensive crisis (HP:0100735)2.38833388
99Amyloidosis (HP:0011034)2.38000036
100Cerebral ischemia (HP:0002637)2.36851752
101Squamous cell carcinoma (HP:0002860)2.35693250
102Skin rash (HP:0000988)2.34767586
103Hepatitis (HP:0012115)2.34238182
104Pulmonary fibrosis (HP:0002206)2.32056281
105IgG deficiency (HP:0004315)2.31897792
106Bronchitis (HP:0012387)2.30278219
107Esophageal varix (HP:0002040)2.25771098
108Recurrent pneumonia (HP:0006532)2.22933783
109Acrocyanosis (HP:0001063)2.22665095
110Prolonged neonatal jaundice (HP:0006579)2.21966829
111Abnormality of B cell number (HP:0010975)2.20132490
112Osteolytic defects of the hand bones (HP:0009699)2.18870171
113Osteolytic defects of the phalanges of the hand (HP:0009771)2.18870171
114Anhidrosis (HP:0000970)2.17244112
115Neutropenia (HP:0001875)2.14619583
116Arthralgia (HP:0002829)2.14348095
117Abnormality of male internal genitalia (HP:0000022)2.11327750
118Recurrent lower respiratory tract infections (HP:0002783)2.10565098
119T lymphocytopenia (HP:0005403)2.10263728
120Recurrent otitis media (HP:0000403)2.10219577
121Cleft eyelid (HP:0000625)2.06886779
122Abnormality of the pleura (HP:0002103)2.06797364
123Premature loss of primary teeth (HP:0006323)2.04806875
124Skin ulcer (HP:0200042)2.04754733
125Spontaneous hematomas (HP:0007420)2.03288167
126Protuberant abdomen (HP:0001538)2.01270462
127Hematochezia (HP:0002573)2.00174589
128Hepatosplenomegaly (HP:0001433)1.99047342
129Tinnitus (HP:0000360)1.97655428
130Colitis (HP:0002583)1.97018871
131Sepsis (HP:0100806)1.95877110
132Osteomyelitis (HP:0002754)1.95866539
133Thyroiditis (HP:0100646)1.95596672
134Inflammation of the large intestine (HP:0002037)1.94802524
135Mucosal telangiectasiae (HP:0100579)1.94745120
136Impaired proprioception (HP:0010831)1.94453974
137Abnormality of the pericardium (HP:0001697)1.93707804
138Thick nail (HP:0001805)1.92657205
139Dry hair (HP:0011359)1.91970918
140Prostate neoplasm (HP:0100787)1.82243448
141Thoracic kyphosis (HP:0002942)1.78592859
142Hyperacusis (HP:0010780)1.77209649
143Abnormality of the endocardium (HP:0004306)1.74617279
144Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.74181228
145Albinism (HP:0001022)1.70976108
146Abnormality of the peritoneum (HP:0002585)1.69707312

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K146.29499256
2PRPF4B4.31902295
3TYK24.04210018
4TBK13.84891370
5JAK33.82045175
6IKBKB3.67389282
7MAP3K133.58713724
8BCR3.27594533
9IRAK43.15377832
10SMG12.78784137
11RIPK42.72849883
12PIM22.72472380
13IKBKE2.68460381
14CHUK2.65066764
15JAK12.52222670
16EIF2AK32.35416803
17EPHB11.91776076
18BLK1.89474675
19NEK91.84923065
20TESK11.79343981
21ARAF1.72970805
22TAF11.62363632
23BMPR21.56489957
24VRK11.48017140
25BMX1.37973805
26SYK1.37868100
27CDC42BPA1.35349718
28MATK1.32162083
29MST41.31490191
30JAK21.30360553
31FGFR41.28243161
32PKN11.24730797
33CDK121.22743025
34EPHA31.20202677
35SIK31.19169372
36PIM11.18067736
37MAP4K11.18044006
38PBK1.15203332
39NME21.14901639
40PASK1.14466209
41IRAK11.06829079
42ABL21.05656627
43PTK61.04918892
44EEF2K1.04676258
45PRKCH1.02477124
46TLK10.99537963
47IRAK30.98353762
48FGFR30.97130623
49KIT0.94679978
50SIK20.93916979
51DDR20.91418104
52MAPKAPK50.90582362
53MAP3K90.88230082
54CSF1R0.87396991
55EIF2AK20.85620707
56MAPKAPK20.84963470
57CSK0.84578610
58PRKCQ0.83341004
59STK40.83146613
60TAOK30.82882351
61MAPK110.79112970
62BCKDK0.79042623
63BTK0.76557302
64VRK20.76279570
65LCK0.75688354
66IRAK20.75497736
67WNK10.74913654
68FLT30.74866767
69ERN10.73129775
70MAP3K100.72731030
71ZAP700.72652831
72HCK0.71415594
73LIMK10.70621308
74KSR20.68778095
75YES10.67906194
76TAOK20.67449768
77PRKCD0.66820231
78TRIB30.66450605
79MAP3K80.66173501
80MELK0.65999671
81NEK10.65189951
82MAPK70.64534185
83CDK40.64396025
84MOS0.60488657
85PTK2B0.59572525
86RET0.58799681
87PDK10.58543020
88CCNB10.57491974
89ABL10.56600647
90ALK0.55429526
91CDK190.54537077
92LYN0.52410548
93SIK10.51966187
94MAPK40.51721069
95TXK0.51526007
96TRPM70.49352787
97RAF10.49271413
98ITK0.49035002
99PRKCI0.48401003
100MAPK120.47904841
101ZAK0.47091031
102MAPKAPK30.46872718
103MAP3K10.46794691
104MAP3K50.46637222
105STK390.46421356
106FGR0.46159467
107DAPK30.45779027
108RPS6KA10.45603771
109WNK40.44182510
110LRRK20.43415697
111PRKCE0.43377290
112DYRK1B0.43358284
113NLK0.43202097
114CDK90.43014342
115BRD40.42544963
116NME10.41002015
117FES0.39629479
118STK100.38835363
119TEC0.38088434
120RPS6KA40.37901775
121STK240.37816451
122MAP3K110.36938546
123ERBB30.34986571
124CDK60.34242902
125PDPK10.33795933
126PAK30.33722439
127EGFR0.33480432
128HIPK20.32125486
129DMPK0.31524283
130ACVR1B0.31442526
131INSR0.30309355
132RPS6KA20.29390151
133STK30.27728889
134MARK30.26597533
135CAMKK10.25044268
136CDC70.24025636
137DAPK10.23486398
138NUAK10.23333440
139RPS6KA50.22152619
140MAP2K60.21778851
141PIK3CA0.21288355
142DAPK20.20890683
143MAP3K20.20657909
144ROCK20.19258739
145SRC0.18409687
146BRAF0.17934428
147AKT10.17455364
148PIK3CG0.14609385
149PRKCZ0.13971883
150PRKACG0.13805099

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053305.94150387
2Graft-versus-host disease_Homo sapiens_hsa053324.68122176
3Autoimmune thyroid disease_Homo sapiens_hsa053203.72366311
4Type I diabetes mellitus_Homo sapiens_hsa049403.72119997
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.20661504
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.15921783
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.60753966
8Leishmaniasis_Homo sapiens_hsa051402.55549187
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.41413572
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.29267957
11Measles_Homo sapiens_hsa051622.27767958
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.12358962
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.11383111
14Viral myocarditis_Homo sapiens_hsa054162.04314841
15TNF signaling pathway_Homo sapiens_hsa046681.92504307
16African trypanosomiasis_Homo sapiens_hsa051431.83058893
17Influenza A_Homo sapiens_hsa051641.81328667
18Toxoplasmosis_Homo sapiens_hsa051451.78814379
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.71989708
20Pertussis_Homo sapiens_hsa051331.63766060
21Rheumatoid arthritis_Homo sapiens_hsa053231.63422699
22Herpes simplex infection_Homo sapiens_hsa051681.60082852
23Osteoclast differentiation_Homo sapiens_hsa043801.56896126
24Legionellosis_Homo sapiens_hsa051341.54191464
25Primary immunodeficiency_Homo sapiens_hsa053401.49115652
26Asthma_Homo sapiens_hsa053101.46017437
27* Chemokine signaling pathway_Homo sapiens_hsa040621.44241064
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.42054372
29* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.41135007
30Shigellosis_Homo sapiens_hsa051311.28521957
31Malaria_Homo sapiens_hsa051441.27729085
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27211304
33Apoptosis_Homo sapiens_hsa042101.27161160
34Prolactin signaling pathway_Homo sapiens_hsa049171.25081948
35Tuberculosis_Homo sapiens_hsa051521.23490120
36B cell receptor signaling pathway_Homo sapiens_hsa046621.12112043
37Antigen processing and presentation_Homo sapiens_hsa046121.06202078
38Salmonella infection_Homo sapiens_hsa051321.02613875
39Hepatitis B_Homo sapiens_hsa051610.96524475
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94496618
41Staphylococcus aureus infection_Homo sapiens_hsa051500.92840269
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.88754010
43Hepatitis C_Homo sapiens_hsa051600.83641995
44Acute myeloid leukemia_Homo sapiens_hsa052210.83131019
45Type II diabetes mellitus_Homo sapiens_hsa049300.79422806
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75528999
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74536508
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71947013
49T cell receptor signaling pathway_Homo sapiens_hsa046600.71471257
50Alcoholism_Homo sapiens_hsa050340.71331948
51Epstein-Barr virus infection_Homo sapiens_hsa051690.66207014
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63811634
53Prion diseases_Homo sapiens_hsa050200.63561574
54Chronic myeloid leukemia_Homo sapiens_hsa052200.61019535
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60565698
56Proteasome_Homo sapiens_hsa030500.59745504
57Amoebiasis_Homo sapiens_hsa051460.57332198
58Other glycan degradation_Homo sapiens_hsa005110.56700478
59Steroid biosynthesis_Homo sapiens_hsa001000.51581054
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51161972
61Phenylalanine metabolism_Homo sapiens_hsa003600.50117846
62Small cell lung cancer_Homo sapiens_hsa052220.50047422
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.49750338
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.49620515
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47849614
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47058267
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.45561154
68Viral carcinogenesis_Homo sapiens_hsa052030.43141963
69Phagosome_Homo sapiens_hsa041450.42414137
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42266379
71Pentose phosphate pathway_Homo sapiens_hsa000300.41619197
72Platelet activation_Homo sapiens_hsa046110.39346685
73p53 signaling pathway_Homo sapiens_hsa041150.39139402
74Hematopoietic cell lineage_Homo sapiens_hsa046400.37335479
75Pancreatic cancer_Homo sapiens_hsa052120.36933976
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36875238
77VEGF signaling pathway_Homo sapiens_hsa043700.35543313
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30053059
79HTLV-I infection_Homo sapiens_hsa051660.27708462
80ErbB signaling pathway_Homo sapiens_hsa040120.22712316
81HIF-1 signaling pathway_Homo sapiens_hsa040660.22091314
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.20356530
83Proteoglycans in cancer_Homo sapiens_hsa052050.19618533
84MAPK signaling pathway_Homo sapiens_hsa040100.19068849
85Fructose and mannose metabolism_Homo sapiens_hsa000510.18691551
86Lysosome_Homo sapiens_hsa041420.17911180
87Tryptophan metabolism_Homo sapiens_hsa003800.17274897
88MicroRNAs in cancer_Homo sapiens_hsa052060.17209456
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.17072092
90Dorso-ventral axis formation_Homo sapiens_hsa043200.16813302
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.16156744
92Renal cell carcinoma_Homo sapiens_hsa052110.13065765
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.12929051
94Non-small cell lung cancer_Homo sapiens_hsa052230.12640391
95Systemic lupus erythematosus_Homo sapiens_hsa053220.10744505
96Glioma_Homo sapiens_hsa052140.10689407
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.10645376
98FoxO signaling pathway_Homo sapiens_hsa040680.09596672
99Inositol phosphate metabolism_Homo sapiens_hsa005620.08391218
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.08076517
101Ras signaling pathway_Homo sapiens_hsa040140.07273356
102Pathways in cancer_Homo sapiens_hsa052000.05784153
103Renin secretion_Homo sapiens_hsa049240.05573997
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.05402296
105Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.05386293
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.04724912
107Endocytosis_Homo sapiens_hsa041440.04536353
108Base excision repair_Homo sapiens_hsa034100.04476372
109Prostate cancer_Homo sapiens_hsa052150.04341691
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.03316355
111Insulin resistance_Homo sapiens_hsa049310.02878774
112One carbon pool by folate_Homo sapiens_hsa006700.02562368
113Colorectal cancer_Homo sapiens_hsa052100.01008125
114RNA degradation_Homo sapiens_hsa030180.00914383
115Carbon metabolism_Homo sapiens_hsa012000.00750286
116Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.00466733
117Bladder cancer_Homo sapiens_hsa05219-0.0478095
118Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.0302814
119Homologous recombination_Homo sapiens_hsa03440-0.0203657
120GnRH signaling pathway_Homo sapiens_hsa04912-0.0129143
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010-0.0121567
122DNA replication_Homo sapiens_hsa03030-0.0087123
123Galactose metabolism_Homo sapiens_hsa00052-0.0022387

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