CCL25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The product of this gene binds to chemokine receptor CCR9. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal cholesterol absorption (GO:0030299)9.94135424
2adhesion of symbiont to host cell (GO:0044650)9.16040386
3virion attachment to host cell (GO:0019062)9.16040386
4angiotensin maturation (GO:0002003)8.54735880
5regulation of guanylate cyclase activity (GO:0031282)7.41498158
6bundle of His cell to Purkinje myocyte communication (GO:0086069)7.29547816
7adhesion of symbiont to host (GO:0044406)7.12745082
8regulation of bile acid biosynthetic process (GO:0070857)6.29108548
9vitamin A metabolic process (GO:0006776)6.21844625
10epoxygenase P450 pathway (GO:0019373)6.03493571
11fat-soluble vitamin biosynthetic process (GO:0042362)5.96791593
12positive regulation of guanylate cyclase activity (GO:0031284)5.84863315
13fructose metabolic process (GO:0006000)5.62774598
14regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.38937977
15regulation of systemic arterial blood pressure by hormone (GO:0001990)5.22322685
16regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)5.22322685
17endocrine process (GO:0050886)5.22322685
18hormone catabolic process (GO:0042447)5.21322981
19digestive system process (GO:0022600)5.13096800
20positive regulation of pseudopodium assembly (GO:0031274)4.96955830
21flavonoid metabolic process (GO:0009812)4.90648446
22regulation of systemic arterial blood pressure (GO:0003073)4.75106957
23antigen processing and presentation of endogenous antigen (GO:0019883)4.73850413
24positive regulation of glycoprotein biosynthetic process (GO:0010560)4.55542802
25negative regulation of keratinocyte proliferation (GO:0010839)4.52612236
26regulation of cGMP biosynthetic process (GO:0030826)4.50995160
27regulation of pseudopodium assembly (GO:0031272)4.46187134
28peptide hormone processing (GO:0016486)4.43218773
29antibacterial humoral response (GO:0019731)4.42492453
30drug metabolic process (GO:0017144)4.39479620
31actin filament depolymerization (GO:0030042)4.38166225
32disruption of cells of other organism (GO:0044364)4.36386898
33killing of cells of other organism (GO:0031640)4.36386898
34antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.31212885
35antimicrobial humoral response (GO:0019730)4.30659306
36receptor guanylyl cyclase signaling pathway (GO:0007168)4.25315905
37NADH metabolic process (GO:0006734)4.20272953
38drug catabolic process (GO:0042737)4.19657718
39innate immune response in mucosa (GO:0002227)4.19494864
40plasma lipoprotein particle assembly (GO:0034377)4.16841226
41very-low-density lipoprotein particle assembly (GO:0034379)4.14185303
42antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.13082955
43regulation of triglyceride catabolic process (GO:0010896)4.08415563
44positive regulation of glycoprotein metabolic process (GO:1903020)4.06736828
45glycolipid catabolic process (GO:0019377)4.06382251
46membrane repolarization during cardiac muscle cell action potential (GO:0086013)4.04508483
47glycosphingolipid catabolic process (GO:0046479)4.03505319
48regulation of vitamin metabolic process (GO:0030656)4.02527603
49urea metabolic process (GO:0019627)4.02160018
50urea cycle (GO:0000050)4.02160018
51mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.00764537
52glucuronate metabolic process (GO:0019585)3.97383610
53uronic acid metabolic process (GO:0006063)3.97383610
54cellular glucuronidation (GO:0052695)3.95107841
55positive regulation of respiratory burst (GO:0060267)3.93264798
56bile acid and bile salt transport (GO:0015721)3.91901971
57desmosome organization (GO:0002934)3.89338307
58defense response to fungus (GO:0050832)3.87830479
59ventricular cardiac muscle cell action potential (GO:0086005)3.87258068
60bicarbonate transport (GO:0015701)3.85783933
61regulation of dendritic cell antigen processing and presentation (GO:0002604)3.85651412
62UDP-N-acetylglucosamine metabolic process (GO:0006047)3.85540837
63phospholipid efflux (GO:0033700)3.82582312
64purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.82496919
653-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.82496919
66cytidine deamination (GO:0009972)3.81194534
67cytidine metabolic process (GO:0046087)3.81194534
68cytidine catabolic process (GO:0006216)3.81194534
69triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.81144689
70hemidesmosome assembly (GO:0031581)3.79829048
71regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.78044394
72protein-lipid complex assembly (GO:0065005)3.77768344
73digestion (GO:0007586)3.76840434
74transepithelial transport (GO:0070633)3.75631173
75response to nitric oxide (GO:0071731)3.74754904
76glucose 6-phosphate metabolic process (GO:0051156)3.74490933
77regulation of cGMP metabolic process (GO:0030823)3.72745449
78intestinal epithelial cell development (GO:0060576)3.71166431
79renal system process involved in regulation of blood volume (GO:0001977)3.68972909
80proline biosynthetic process (GO:0006561)3.68222735
81regulation of heart rate by cardiac conduction (GO:0086091)3.63712342
82cholesterol efflux (GO:0033344)3.62679050
83cellular response to nitric oxide (GO:0071732)3.61497298
84calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.59193371
85arginine metabolic process (GO:0006525)3.57875712
86mucosal immune response (GO:0002385)3.57460637
87positive regulation of lipoprotein lipase activity (GO:0051006)3.57353452
88positive regulation of triglyceride lipase activity (GO:0061365)3.57353452
89nitrogen cycle metabolic process (GO:0071941)3.53742672
90regulation of Golgi to plasma membrane protein transport (GO:0042996)3.53111264
91alkaloid metabolic process (GO:0009820)3.52317196
92ATP synthesis coupled proton transport (GO:0015986)3.51732925
93energy coupled proton transport, down electrochemical gradient (GO:0015985)3.51732925
94modified amino acid transport (GO:0072337)3.51412447
95membrane repolarization during action potential (GO:0086011)3.47479616
96regulation of respiratory burst (GO:0060263)3.44449324
97hepatocyte apoptotic process (GO:0097284)3.43323033
98sperm capacitation (GO:0048240)3.41719944
99drinking behavior (GO:0042756)3.41397009
100fat-soluble vitamin metabolic process (GO:0006775)3.40754855
101positive regulation of cGMP biosynthetic process (GO:0030828)3.39134811
102sulfate transmembrane transport (GO:1902358)3.37526254
103mRNA modification (GO:0016556)3.37474591
104vitamin transport (GO:0051180)3.35949454
105midgut development (GO:0007494)3.35483965
106regulation of keratinocyte proliferation (GO:0010837)3.33146936
107lipoprotein metabolic process (GO:0042157)3.31964607
108glutamine family amino acid biosynthetic process (GO:0009084)3.31374548
109vitamin transmembrane transport (GO:0035461)3.29970255
110organ or tissue specific immune response (GO:0002251)3.29363843
111positive regulation of Cdc42 GTPase activity (GO:0043089)3.28689196
112phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.27359112
113cardiac conduction (GO:0061337)3.27304335
114homocysteine metabolic process (GO:0050667)3.25902840
115ceramide catabolic process (GO:0046514)3.23541739
116cholesterol transport (GO:0030301)3.23003241
117sterol transport (GO:0015918)3.23003241
118regulation of cholesterol esterification (GO:0010872)3.21684426
119diacylglycerol metabolic process (GO:0046339)3.21611105
120filopodium assembly (GO:0046847)3.21159694
121response to hepatocyte growth factor (GO:0035728)3.17794248
122cellular response to hepatocyte growth factor stimulus (GO:0035729)3.17794248
123maintenance of gastrointestinal epithelium (GO:0030277)3.17739428
124nucleoside diphosphate biosynthetic process (GO:0009133)3.16470372
125neurotransmitter catabolic process (GO:0042135)3.16389442
126cellular response to reactive nitrogen species (GO:1902170)3.14356369
127keratinocyte proliferation (GO:0043616)3.13934249
128tight junction assembly (GO:0070830)3.13879556
129glomerular filtration (GO:0003094)3.13534384
130negative regulation of B cell apoptotic process (GO:0002903)3.11654113
131thyroid hormone metabolic process (GO:0042403)3.11585812
132NIK/NF-kappaB signaling (GO:0038061)3.09510116
133eosinophil chemotaxis (GO:0048245)3.08561714
134negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.06942446
135sexual reproduction (GO:0019953)3.06925935
136regulation of cholesterol homeostasis (GO:2000188)3.06919024
137auditory receptor cell differentiation (GO:0042491)3.06678124
138glycosylceramide metabolic process (GO:0006677)3.05646777
139exogenous drug catabolic process (GO:0042738)3.05361931
140respiratory electron transport chain (GO:0022904)3.03678685
141* regulation of cellular extravasation (GO:0002691)3.01618319
142bile acid metabolic process (GO:0008206)3.00884981
143cholesterol homeostasis (GO:0042632)2.99596734
144transcytosis (GO:0045056)2.99528810
145sphingolipid catabolic process (GO:0030149)2.98601779
146sterol homeostasis (GO:0055092)2.98497703
147cGMP-mediated signaling (GO:0019934)2.98337989
148regulation of digestive system process (GO:0044058)2.98284154
149fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.97726597
150pyrimidine ribonucleoside catabolic process (GO:0046133)2.97238366
151complement activation, classical pathway (GO:0006958)2.96118196
152positive regulation of digestive system process (GO:0060456)2.93808047
153peptide catabolic process (GO:0043171)2.92436430
154electron transport chain (GO:0022900)2.92404108
155activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.90409755
156mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.87870232
157sulfate transport (GO:0008272)2.87823969
158lipoprotein transport (GO:0042953)2.87547786
159positive regulation of antigen processing and presentation (GO:0002579)2.87483597
160cellular response to vitamin (GO:0071295)2.86453291
161branching involved in labyrinthine layer morphogenesis (GO:0060670)2.84196957
162intestinal absorption (GO:0050892)11.3365862

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDX2_20551321_ChIP-Seq_CACO-2_Human5.52744982
2HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.84616979
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.69181550
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.39787585
5SOX2_27498859_Chip-Seq_STOMACH_Mouse3.38250084
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.38045891
7GATA4_25053715_ChIP-Seq_YYC3_Human3.28001367
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.93942080
9GATA6_25053715_ChIP-Seq_YYC3_Human2.92295442
10SOX2_20726797_ChIP-Seq_SW620_Human2.80634006
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.64318736
12TCF4_18268006_ChIP-ChIP_LS174T_Human2.48965403
13FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.47311140
14AR_21909140_ChIP-Seq_LNCAP_Human2.17536549
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.06112119
16TP63_17297297_ChIP-ChIP_HaCaT_Human11.7611034
17CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.89230045
18ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.85958068
19LXR_22292898_ChIP-Seq_THP-1_Human1.85189244
20GATA1_22025678_ChIP-Seq_K562_Human1.81909239
21* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.81278606
22IRF8_21731497_ChIP-ChIP_J774_Mouse1.80370014
23EGR1_23403033_ChIP-Seq_LIVER_Mouse1.79639120
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.76387564
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.75294970
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.75165269
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71478338
28PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.65983912
29PPARA_22158963_ChIP-Seq_LIVER_Mouse1.64821077
30TP53_16413492_ChIP-PET_HCT116_Human1.63907131
31EZH2_22144423_ChIP-Seq_EOC_Human1.56714575
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.56611540
33FOXM1_26456572_ChIP-Seq_MCF-7_Human1.56195044
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.45921016
35EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.42056653
36BCAT_22108803_ChIP-Seq_LS180_Human1.41345128
37KLF5_25053715_ChIP-Seq_YYC3_Human1.40723175
38CLOCK_20551151_ChIP-Seq_293T_Human1.40622858
39BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.40096838
40AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.39918716
41FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.35085871
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.31631717
43SA1_27219007_Chip-Seq_Bcells_Human1.30760611
44EGR1_19032775_ChIP-ChIP_M12_Human1.30252108
45STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.29961373
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29000784
47IRF8_22096565_ChIP-ChIP_GC-B_Human1.28951710
48PPAR_26484153_Chip-Seq_NCI-H1993_Human1.28903357
49RACK7_27058665_Chip-Seq_MCF-7_Human1.28894457
50FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.28642169
51KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28239123
52BCL6_27268052_Chip-Seq_Bcells_Human1.27504116
53HNF4A_19822575_ChIP-Seq_HepG2_Human1.26493900
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.25984172
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25325590
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25325590
57LXR_22158963_ChIP-Seq_LIVER_Mouse1.24836193
58FUS_26573619_Chip-Seq_HEK293_Human1.24021529
59CTNNB1_20460455_ChIP-Seq_HCT116_Human1.23830260
60BCOR_27268052_Chip-Seq_Bcells_Human1.23295732
61TET1_21451524_ChIP-Seq_MESCs_Mouse1.22571655
62ELF5_23300383_ChIP-Seq_T47D_Human1.21926475
63RUNX1_27514584_Chip-Seq_MCF-7_Human1.21611501
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19600847
65CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17871884
66STAT1_17558387_ChIP-Seq_HELA_Human1.16684583
67PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15302950
68CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.15181304
69TCF4_22108803_ChIP-Seq_LS180_Human1.12552432
70TDRD3_21172665_ChIP-Seq_MCF-7_Human1.12009791
71NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.11607787
72FOXO3_23340844_ChIP-Seq_DLD1_Human1.11587690
73SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11464355
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10076014
75CTCF_27219007_Chip-Seq_Bcells_Human1.09303238
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09214087
77FOXA1_25552417_ChIP-Seq_VCAP_Human1.08638539
78CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08156005
79CDX2_22108803_ChIP-Seq_LS180_Human1.07940508
80VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07390109
81TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07094488
82* GATA2_19941826_ChIP-Seq_K562_Human1.06620725
83NANOG_20526341_ChIP-Seq_ESCs_Human1.05904909
84SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05834192
85GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05467776
86TAL1_26923725_Chip-Seq_HPCs_Mouse1.05434685
87VDR_24763502_ChIP-Seq_THP-1_Human1.05204561
88SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05164513
89P53_22387025_ChIP-Seq_ESCs_Mouse1.02626092
90JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.02194030
91SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00456707
92TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00231622
93PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00207042
94NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.99994830
95PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99932209
96SMAD3_21741376_ChIP-Seq_EPCs_Human0.99252479
97NFE2_27457419_Chip-Seq_LIVER_Mouse0.99069136
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98742723
99GATA1_26923725_Chip-Seq_HPCs_Mouse0.97966049
100SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97541320
101DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97488757
102OCT4_18555785_Chip-Seq_ESCs_Mouse0.97072954
103FOXA2_19822575_ChIP-Seq_HepG2_Human0.97017479
104P63_26484246_Chip-Seq_KERATINOCYTES_Human0.96844681
105TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96474882
106GATA1_19941826_ChIP-Seq_K562_Human0.96300870
107RXR_22108803_ChIP-Seq_LS180_Human0.95689703
108* MYC_19829295_ChIP-Seq_ESCs_Human0.94299581
109CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93566014
110TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93445293
111ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93165596
112IRF8_27001747_Chip-Seq_BMDM_Mouse0.91860759
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91468320
114FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.90559758
115ZFX_18555785_Chip-Seq_ESCs_Mouse0.90347964
116CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90246133
117GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89098427
118SMAD3_21741376_ChIP-Seq_HESCs_Human0.88319971
119RAD21_21589869_ChIP-Seq_MESCs_Mouse0.88105217
120TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87618012
121P300_18555785_Chip-Seq_ESCs_Mouse0.87605060
122VDR_21846776_ChIP-Seq_THP-1_Human0.87069600
123GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86873177
124E2F1_18555785_Chip-Seq_ESCs_Mouse0.86845258
125SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.86704757
126RARG_19884340_ChIP-ChIP_MEFs_Mouse0.86567537
127STAT6_21828071_ChIP-Seq_BEAS2B_Human0.86551409
128NANOG_18555785_Chip-Seq_ESCs_Mouse0.85712947
129VDR_24787735_ChIP-Seq_THP-1_Human0.85622497
130GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.85449232
131PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85047267
132PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.84955988
133CEBPB_22108803_ChIP-Seq_LS180_Human0.84943074
134* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.84690953
135RXR_22158963_ChIP-Seq_LIVER_Mouse0.83638623
136CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.83482034
137ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.83129807
138TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.83092965
139ISL1_27105846_Chip-Seq_CPCs_Mouse0.82977223
140PRDM14_20953172_ChIP-Seq_ESCs_Human0.82830822
141NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.82698071
142* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.82684930
143ESR1_20079471_ChIP-ChIP_T-47D_Human0.81820282
144P53_22127205_ChIP-Seq_FIBROBLAST_Human0.81678313
145CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.81560002
146FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81044924
147CMYC_18555785_Chip-Seq_ESCs_Mouse0.81017700
148SOX2_18555785_Chip-Seq_ESCs_Mouse0.80638219
149MYC_18940864_ChIP-ChIP_HL60_Human0.79809286
150JARID2_20075857_ChIP-Seq_MESCs_Mouse0.79382702
151EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.79310269
152KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.79024175
153E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.78956436
154FLI1_27457419_Chip-Seq_LIVER_Mouse0.78401940
155E2F7_22180533_ChIP-Seq_HELA_Human0.77493295
156IKZF1_21737484_ChIP-ChIP_HCT116_Human0.77481002
157VDR_22108803_ChIP-Seq_LS180_Human0.76652259
158ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.74087408
159STAT1_20625510_ChIP-Seq_HELA_Human0.73622509
160NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.73194625
161SUZ12_27294783_Chip-Seq_NPCs_Mouse0.73093229
162FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.71332891

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat7.95998010
2MP0005360_urolithiasis6.99369231
3MP0001666_abnormal_nutrient_absorption4.00005155
4MP0001873_stomach_inflammation3.81409691
5MP0000462_abnormal_digestive_system3.63063581
6MP0009379_abnormal_foot_pigmentation3.61081675
7MP0001346_abnormal_lacrimal_gland3.55069985
8MP0002876_abnormal_thyroid_physiology3.15932575
9MP0004264_abnormal_extraembryonic_tissu2.93217617
10MP0005367_renal/urinary_system_phenotyp2.86876071
11MP0000516_abnormal_urinary_system2.86876071
12MP0010234_abnormal_vibrissa_follicle2.62067605
13MP0003183_abnormal_peptide_metabolism2.60713001
14MP0005310_abnormal_salivary_gland2.43629915
15MP0005409_darkened_coat_color2.28202368
16MP0000538_abnormal_urinary_bladder2.22926445
17MP0001348_abnormal_lacrimal_gland2.21523902
18MP0001663_abnormal_digestive_system2.16446051
19MP0008004_abnormal_stomach_pH2.12143113
20MP0005085_abnormal_gallbladder_physiolo2.08917738
21MP0005381_digestive/alimentary_phenotyp2.06563481
22MP0002139_abnormal_hepatobiliary_system2.01085923
23MP0002277_abnormal_respiratory_mucosa1.97177393
24MP0003252_abnormal_bile_duct1.94573994
25MP0003866_abnormal_defecation1.84296885
26MP0000613_abnormal_salivary_gland1.80090365
27* MP0010155_abnormal_intestine_physiology1.78873887
28MP0003453_abnormal_keratinocyte_physiol1.76628111
29MP0005166_decreased_susceptibility_to1.76147505
30MP0003300_gastrointestinal_ulcer1.75407857
31MP0000537_abnormal_urethra_morphology1.75250468
32MP0000383_abnormal_hair_follicle1.75212518
33MP0010678_abnormal_skin_adnexa1.72204620
34MP0004858_abnormal_nervous_system1.62737073
35MP0001664_abnormal_digestion1.53620402
36MP0003868_abnormal_feces_composition1.51426797
37MP0001485_abnormal_pinna_reflex1.50606167
38MP0000566_synostosis1.48200651
39MP0003693_abnormal_embryo_hatching1.44244228
40MP0004019_abnormal_vitamin_homeostasis1.37893554
41MP0005645_abnormal_hypothalamus_physiol1.37187048
42MP0002098_abnormal_vibrissa_morphology1.33717671
43MP0008875_abnormal_xenobiotic_pharmacok1.32841016
44MP0000477_abnormal_intestine_morphology1.32590370
45MP0001188_hyperpigmentation1.32075387
46MP0004782_abnormal_surfactant_physiolog1.29469596
47MP0003879_abnormal_hair_cell1.29340269
48MP0001765_abnormal_ion_homeostasis1.28363774
49MP0000490_abnormal_crypts_of1.27920243
50MP0010329_abnormal_lipoprotein_level1.24775338
51MP0000470_abnormal_stomach_morphology1.23045501
52MP0002136_abnormal_kidney_physiology1.22282108
53MP0010352_gastrointestinal_tract_polyps1.22075555
54MP0008872_abnormal_physiological_respon1.21602211
55MP0005636_abnormal_mineral_homeostasis1.18334661
56MP0005365_abnormal_bile_salt1.17296190
57MP0000685_abnormal_immune_system1.15978202
58MP0002118_abnormal_lipid_homeostasis1.09571376
59MP0005670_abnormal_white_adipose1.05814830
60MP0001849_ear_inflammation1.05087904
61MP0009840_abnormal_foam_cell1.04148788
62MP0003724_increased_susceptibility_to1.04129284
63MP0001790_abnormal_immune_system1.02883700
64MP0005387_immune_system_phenotype1.02883700
65* MP0001845_abnormal_inflammatory_respons1.02822229
66MP0009697_abnormal_copulation1.02699342
67MP0000427_abnormal_hair_cycle1.02140326
68MP0009785_altered_susceptibility_to1.01215036
69MP0000465_gastrointestinal_hemorrhage0.99834547
70MP0005448_abnormal_energy_balance0.99579595
71MP0005584_abnormal_enzyme/coenzyme_acti0.98042370
72MP0000467_abnormal_esophagus_morphology0.97888976
73MP0004270_analgesia0.97786924
74MP0003787_abnormal_imprinting0.96927977
75MP0005535_abnormal_body_temperature0.95573512
76MP0002166_altered_tumor_susceptibility0.95057417
77MP0002163_abnormal_gland_morphology0.94231692
78MP0005025_abnormal_response_to0.92122370
79MP0001756_abnormal_urination0.91292785
80MP0005084_abnormal_gallbladder_morpholo0.88765771
81MP0002938_white_spotting0.88459503
82MP0002138_abnormal_hepatobiliary_system0.87605359
83MP0004147_increased_porphyrin_level0.87528425
84MP0002089_abnormal_postnatal_growth/wei0.86145616
85MP0002971_abnormal_brown_adipose0.84566523
86MP0003436_decreased_susceptibility_to0.84325622
87MP0000579_abnormal_nail_morphology0.84033317
88MP0008469_abnormal_protein_level0.83428222
89MP0009115_abnormal_fat_cell0.80781345
90MP0005451_abnormal_body_composition0.79692897
91MP0000604_amyloidosis0.78561773
92MP0003303_peritoneal_inflammation0.78114829
93MP0003329_amyloid_beta_deposits0.77542234
94MP0009764_decreased_sensitivity_to0.75756586
95MP0001764_abnormal_homeostasis0.75435540
96MP0000230_abnormal_systemic_arterial0.73197296
97MP0005319_abnormal_enzyme/_coenzyme0.73190279
98MP0009384_cardiac_valve_regurgitation0.71812860
99MP0002396_abnormal_hematopoietic_system0.71719896
100MP0004947_skin_inflammation0.70230626
101MP0003191_abnormal_cellular_cholesterol0.69790737
102MP0006082_CNS_inflammation0.69771929
103MP0009642_abnormal_blood_homeostasis0.67154290
104MP0003123_paternal_imprinting0.66633306
105MP0001800_abnormal_humoral_immune0.65078802
106MP0000249_abnormal_blood_vessel0.64042349
107MP0000678_abnormal_parathyroid_gland0.63397345
108MP0002148_abnormal_hypersensitivity_rea0.62720091
109MP0001835_abnormal_antigen_presentation0.61361235
110MP0004510_myositis0.59508159
111MP0003718_maternal_effect0.59383782
112MP0002796_impaired_skin_barrier0.58059375
113MP0002006_tumorigenesis0.56605110
114MP0010386_abnormal_urinary_bladder0.56515736
115MP0002896_abnormal_bone_mineralization0.56400653
116MP0001533_abnormal_skeleton_physiology0.55439604
117MP0001216_abnormal_epidermal_layer0.55194161
118MP0005000_abnormal_immune_tolerance0.54380287
119MP0009643_abnormal_urine_homeostasis0.53018207
120MP0001881_abnormal_mammary_gland0.52937282
121MP0005174_abnormal_tail_pigmentation0.52884574
122MP0003763_abnormal_thymus_physiology0.52718665
123MP0002822_catalepsy0.51965552
124MP0005334_abnormal_fat_pad0.50067639
125MP0001270_distended_abdomen0.48919661
126MP0005165_increased_susceptibility_to0.47598353
127MP0003638_abnormal_response/metabolism_0.47535054
128MP0003941_abnormal_skin_development0.47364456
129MP0000627_abnormal_mammary_gland0.47342574
130MP0005332_abnormal_amino_acid0.46103383
131MP0009333_abnormal_splenocyte_physiolog0.41765557
132MP0003878_abnormal_ear_physiology0.41727824
133MP0005377_hearing/vestibular/ear_phenot0.41727824
134MP0002132_abnormal_respiratory_system0.40473809
135MP0001501_abnormal_sleep_pattern0.40323963
136MP0000609_abnormal_liver_physiology0.39587043
137MP0005671_abnormal_response_to0.39436200
138MP0001529_abnormal_vocalization0.38893446
139MP0000377_abnormal_hair_follicle0.37910099
140MP0003806_abnormal_nucleotide_metabolis0.34438485
141MP0003119_abnormal_digestive_system0.33856189
142MP0002095_abnormal_skin_pigmentation0.33731994
143MP0000703_abnormal_thymus_morphology0.33255436
144MP0009053_abnormal_anal_canal0.31752049
145MP0004484_altered_response_of0.31246923
146MP0004043_abnormal_pH_regulation0.31238381
147MP0010771_integument_phenotype0.29988093

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)7.29701746
2Right ventricular cardiomyopathy (HP:0011663)5.69864175
3Acanthocytosis (HP:0001927)5.16422208
4Hypobetalipoproteinemia (HP:0003563)5.11791969
5Abnormality of glutamine family amino acid metabolism (HP:0010902)5.10593601
6Systemic lupus erythematosus (HP:0002725)5.10411742
7Conjugated hyperbilirubinemia (HP:0002908)4.47182474
8Ventricular fibrillation (HP:0001663)4.47075331
9Pustule (HP:0200039)4.33247350
10Microretrognathia (HP:0000308)4.19461951
11Abnormality of proline metabolism (HP:0010907)3.97811941
12Hydroxyprolinuria (HP:0003080)3.97811941
13Nausea (HP:0002018)3.87710965
14Cheilitis (HP:0100825)3.86967919
15Abnormality of the gastric mucosa (HP:0004295)3.79908660
16Congenital sensorineural hearing impairment (HP:0008527)3.73129068
17Rectal prolapse (HP:0002035)3.67586193
18Chronic mucocutaneous candidiasis (HP:0002728)3.64204467
19Recurrent cutaneous fungal infections (HP:0011370)3.64204467
20Malnutrition (HP:0004395)3.61294413
21Proximal tubulopathy (HP:0000114)3.50077441
22Premature loss of primary teeth (HP:0006323)3.41070973
23Hyperglycinuria (HP:0003108)3.40052479
24Thin bony cortex (HP:0002753)3.37164879
25Autoimmune thrombocytopenia (HP:0001973)3.34306034
26Wide cranial sutures (HP:0010537)3.32664074
27Autoimmune hemolytic anemia (HP:0001890)3.25273821
28Nephrolithiasis (HP:0000787)3.20963708
29Amniotic constriction ring (HP:0009775)3.19825504
30Abnormality of placental membranes (HP:0011409)3.19825504
31Onycholysis (HP:0001806)3.16493836
32Plantar hyperkeratosis (HP:0007556)3.15950398
33Xanthomatosis (HP:0000991)3.15748957
34Poikilocytosis (HP:0004447)3.14794130
35Increased purine levels (HP:0004368)3.08526790
36Hyperuricemia (HP:0002149)3.08526790
37Eczematoid dermatitis (HP:0000976)3.05455864
38Nasolacrimal duct obstruction (HP:0000579)3.04121850
39Decreased circulating renin level (HP:0003351)3.03887689
40Hypophosphatemia (HP:0002148)3.00325699
41Abnormality of the vitamin B12 metabolism (HP:0004341)2.97590537
42Abnormality of serine family amino acid metabolism (HP:0010894)2.93274953
43Abnormality of glycine metabolism (HP:0010895)2.93274953
44Abnormality of the lacrimal duct (HP:0011481)2.92013176
45Abnormality of small intestinal villus morphology (HP:0011472)2.89939631
46Villous atrophy (HP:0011473)2.89939631
47Pili torti (HP:0003777)2.89216541
48Abnormality of urine glucose concentration (HP:0011016)2.88164274
49Glycosuria (HP:0003076)2.88164274
50Alkalosis (HP:0001948)2.86179151
51Palpitations (HP:0001962)2.85876412
52Abnormality of monocarboxylic acid metabolism (HP:0010996)2.85621575
53Abdominal distention (HP:0003270)2.85588630
54Milia (HP:0001056)2.80928063
55Steatorrhea (HP:0002570)2.80888298
56Facial shape deformation (HP:0011334)2.80486464
57Potter facies (HP:0002009)2.80486464
58Ankyloglossia (HP:0010296)2.80284535
59Hyperparathyroidism (HP:0000843)2.79216217
60Poikiloderma (HP:0001029)2.76967635
61Fragile skin (HP:0001030)2.74076259
62Syncope (HP:0001279)2.72252917
63Glomerulonephritis (HP:0000099)2.70647532
64Metabolic alkalosis (HP:0200114)2.69962890
65Confusion (HP:0001289)2.69841398
66Woolly hair (HP:0002224)2.68791169
67Fat malabsorption (HP:0002630)2.67923228
68Mitochondrial inheritance (HP:0001427)2.67805517
69Abnormality of vitamin B metabolism (HP:0004340)2.67690837
70Periodontitis (HP:0000704)2.66382125
71Abnormality of purine metabolism (HP:0004352)2.65846715
72Chronic diarrhea (HP:0002028)2.64636665
73Hyperammonemia (HP:0001987)2.64078801
74Megaloblastic anemia (HP:0001889)2.62207909
75Hepatocellular necrosis (HP:0001404)2.59980170
76Abnormality of complement system (HP:0005339)2.56473744
77Xerostomia (HP:0000217)2.53285314
78Hyperactive renin-angiotensin system (HP:0000841)2.52878328
79Abnormality of aspartate family amino acid metabolism (HP:0010899)2.52264212
80Alacrima (HP:0000522)2.51096142
81Complement deficiency (HP:0004431)2.47985766
82Ridged nail (HP:0001807)2.45886914
83Abnormal biliary tract morphology (HP:0012440)2.45826180
84Enlarged epiphyses (HP:0010580)2.41230218
85Palmoplantar hyperkeratosis (HP:0000972)2.40741539
86Acute encephalopathy (HP:0006846)2.38745422
87Hypoplasia of dental enamel (HP:0006297)2.38083547
88Abnormality of nucleobase metabolism (HP:0010932)2.37747751
89Focal segmental glomerulosclerosis (HP:0000097)2.37666801
90Lipid accumulation in hepatocytes (HP:0006561)2.36008873
91Widely patent fontanelles and sutures (HP:0004492)2.35930921
92Recurrent fungal infections (HP:0002841)2.35441211
93Increased hepatocellular lipid droplets (HP:0006565)2.35028894
94Abnormality of the nasolacrimal system (HP:0000614)2.35013034
95Nephritis (HP:0000123)2.33385800
96Inflammation of the large intestine (HP:0002037)2.32744021
97Decreased lacrimation (HP:0000633)2.32589526
98Hypotension (HP:0002615)2.30324924
99Abnormal hemoglobin (HP:0011902)2.30262859
100Abnormality of renin-angiotensin system (HP:0000847)2.26621649
101Delayed epiphyseal ossification (HP:0002663)2.26549260
102Hypolipoproteinemia (HP:0010981)2.26466908
103Hemorrhage of the eye (HP:0011885)2.26059873
104Preauricular pit (HP:0004467)2.24491822
105Periauricular skin pits (HP:0100277)2.24491822
106Aplasia cutis congenita (HP:0001057)2.23636824
107Hyperphosphatemia (HP:0002905)2.23192802
108Cerebral palsy (HP:0100021)2.22562643
109Trismus (HP:0000211)2.22010604
110Pancreatitis (HP:0001733)2.21725285
111Hepatic necrosis (HP:0002605)2.21527122
112Palmar hyperkeratosis (HP:0010765)2.21291533
113Colon cancer (HP:0003003)2.20808459
114Abnormal glucose tolerance (HP:0001952)2.19927838
115Metabolic acidosis (HP:0001942)2.19438447
116Epidermoid cyst (HP:0200040)2.19292353
117Ventricular arrhythmia (HP:0004308)2.18366211
118Hyperphosphaturia (HP:0003109)2.17876879
119Dehydration (HP:0001944)2.17633884
120Increased CSF lactate (HP:0002490)2.17567240
121Protuberant abdomen (HP:0001538)2.16040614
122Acute necrotizing encephalopathy (HP:0006965)2.15524105
123Abnormality of the costochondral junction (HP:0000919)2.15450994
124Pigmentary retinal degeneration (HP:0001146)2.15039688
125Dicarboxylic aciduria (HP:0003215)2.14041701
126Abnormality of dicarboxylic acid metabolism (HP:0010995)2.14041701
127Gout (HP:0001997)2.13459292
128B lymphocytopenia (HP:0010976)2.10006667
129Abnormality of B cell number (HP:0010975)2.10006667
130Abnormal mitochondria in muscle tissue (HP:0008316)2.09680175
131Mixed hearing impairment (HP:0000410)2.07630539
132Abnormality of magnesium homeostasis (HP:0004921)2.07432405
133Gingivitis (HP:0000230)2.02461913
134Increased mean platelet volume (HP:0011877)2.01102717
135Growth hormone excess (HP:0000845)2.00835049
136Abnormality of the preputium (HP:0100587)2.00511158
137Gastrointestinal dysmotility (HP:0002579)1.99459996
138Subcapsular cataract (HP:0000523)1.98485840
139Abnormality of vitamin metabolism (HP:0100508)1.97519585
140Intrahepatic cholestasis (HP:0001406)1.97458013
141Renal tubular acidosis (HP:0001947)1.97286756
142Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.97012622
143Atrophic scars (HP:0001075)1.96996581
144Irritability (HP:0000737)1.95615122
145Gastrointestinal inflammation (HP:0004386)1.95270708
146Posterior subcapsular cataract (HP:0007787)1.95107625
147Fragile nails (HP:0001808)1.95098772
148Gastrointestinal stroma tumor (HP:0100723)1.93198528
149Severe combined immunodeficiency (HP:0004430)1.92258399
150Reduced antithrombin III activity (HP:0001976)1.90262521
151Biliary tract neoplasm (HP:0100574)1.89593982
152Micronodular cirrhosis (HP:0001413)1.86804015
153CNS demyelination (HP:0007305)1.86789613
154Progressive macrocephaly (HP:0004481)1.86550528
155Abnormal urine phosphate concentration (HP:0012599)1.86323129
156Hypercortisolism (HP:0001578)1.85198409
157Prolonged QT interval (HP:0001657)1.82662440
158Abnormality of sulfur amino acid metabolism (HP:0004339)1.82046873
159Multiple lipomas (HP:0001012)1.80377068
160Emphysema (HP:0002097)1.79625734
161Glomerulosclerosis (HP:0000096)1.78995806
162Abnormality of pyrimidine metabolism (HP:0004353)1.76440920
163Skin rash (HP:0000988)1.75455478
164Hypocalcemia (HP:0002901)1.72617392
165Paresthesia (HP:0003401)1.71963465
166Segmental peripheral demyelination/remyelination (HP:0003481)1.71722201
167Renal tubular dysfunction (HP:0000124)1.70079795
168Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.69333564
169Hypoalbuminemia (HP:0003073)1.69323004
170Abnormal albumin level (HP:0012116)1.69323004
171Symptomatic seizures (HP:0011145)1.69046160
172Abnormal enzyme/coenzyme activity (HP:0012379)1.67811015

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B7.74982181
2LMTK26.33127662
3NME15.96439628
4FRK5.24876485
5ERN14.76146311
6MST44.57512124
7NUAK13.17199692
8RIPK13.12073111
9PRKG22.71238498
10MST1R2.40287833
11CASK2.01880537
12TESK21.97751432
13TTK1.97457618
14MAPK151.88206694
15AKT31.82017000
16PBK1.81384915
17MAP4K11.81120656
18EPHB21.78326582
19GRK61.76539475
20MAP3K141.74295517
21PDK21.69681365
22MAP2K21.69428275
23MAP3K101.54956335
24ERBB21.46245006
25MAP2K61.39710412
26TNIK1.32864912
27MET1.29762541
28EPHA21.20716700
29PRPF4B1.20644567
30FGFR31.17326798
31MYLK1.16970999
32MAP3K131.16305018
33MAP3K11.15360317
34TSSK61.13852968
35BCR1.12546051
36PTK61.11466362
37MAPK111.11449359
38CDK81.10867091
39EPHA41.04860419
40STK391.04135772
41MAP3K111.02951982
42CDC42BPA1.01817445
43CDK121.00015777
44TYK20.96421964
45PASK0.94827327
46TESK10.93034212
47IRAK10.92228948
48TAOK30.92146317
49LATS10.91591298
50CCNB10.88009461
51FGFR40.87146804
52PDPK10.87007849
53RPS6KB20.86264093
54VRK10.86185555
55MAP3K20.86112923
56IRAK30.85872102
57BMPR1B0.85618713
58MAP3K120.82400746
59PIK3CA0.81916353
60CDK190.80550744
61YES10.79618960
62AURKB0.78662939
63ERBB40.73942767
64DDR20.73737091
65BRD40.71850423
66PRKACG0.69332840
67NLK0.68008685
68MELK0.67896592
69CAMK2B0.67521791
70PRKCI0.67159109
71PTK20.66702697
72DAPK20.65053318
73DYRK1B0.64894490
74KIT0.64604117
75CDK90.64442024
76CAMK2G0.63936037
77PRKCZ0.62338301
78PDK10.62336620
79TLK10.61979023
80TAOK10.61485399
81PRKAA20.61115240
82MATK0.60833468
83FER0.60553295
84SCYL20.58769646
85PIM10.56638801
86CSK0.56497353
87ZAP700.55100558
88CHUK0.54691068
89SYK0.54112287
90RIPK40.54004452
91BMPR20.53550383
92JAK30.53486570
93EIF2AK20.51449313
94IKBKE0.50448635
95BTK0.50062842
96CDK30.49829843
97RET0.49482820
98EPHB10.49122166
99EPHA30.48696035
100CSF1R0.46572848
101MAP3K70.46425269
102TRIM280.45919373
103KSR10.45707075
104DYRK30.43397854
105CDK70.43116619
106PLK30.42933485
107INSRR0.42593553
108FYN0.42148842
109ITK0.42045386
110KSR20.41941979
111TRIB30.41606386
112PRKCD0.41000407
113BMX0.39161488
114FGR0.38196621
115CAMK2D0.37855582
116OXSR10.36792128
117STK38L0.36780166
118ABL20.36745425
119IRAK40.35649530
120GRK10.35575138
121PLK10.35259641
122SIK30.35216975
123LYN0.35041034
124STK30.34956349
125STK100.34935230
126MAP2K10.34581456
127MAP3K80.34307679
128SMG10.33072545
129ICK0.32044442
130MAPKAPK20.31381966
131STK110.30887830
132TBK10.30446823
133NEK60.30138071
134TEC0.29947379
135LCK0.29834037
136PRKDC0.29107504
137PRKCQ0.28359580
138GRK50.27563245
139JAK10.27040545
140CDK60.26850900
141PAK40.26667773
142LRRK20.26151310
143SRPK10.25446883
144CSNK1A10.25423177
145SRC0.25225974
146ATM0.24876184
147PDGFRA0.24365094
148STK240.24293281
149JAK20.23674097
150KDR0.23644488
151PRKCA0.23529751
152NEK20.23506452

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049755.65384122
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.26885881
3Renin-angiotensin system_Homo sapiens_hsa046144.06666450
4Vitamin digestion and absorption_Homo sapiens_hsa049773.90284725
5Mineral absorption_Homo sapiens_hsa049783.45539280
6Cyanoamino acid metabolism_Homo sapiens_hsa004603.13475923
7Caffeine metabolism_Homo sapiens_hsa002323.07901230
8Histidine metabolism_Homo sapiens_hsa003402.63715295
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.38783394
10Carbohydrate digestion and absorption_Homo sapiens_hsa049732.38670364
11Folate biosynthesis_Homo sapiens_hsa007902.24951681
12Protein digestion and absorption_Homo sapiens_hsa049742.17069587
13Galactose metabolism_Homo sapiens_hsa000522.12020873
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.08168045
15Oxidative phosphorylation_Homo sapiens_hsa001902.04241210
16Starch and sucrose metabolism_Homo sapiens_hsa005002.01663184
17Asthma_Homo sapiens_hsa053101.95925703
18Fructose and mannose metabolism_Homo sapiens_hsa000511.88442284
19Parkinsons disease_Homo sapiens_hsa050121.65391893
20Bile secretion_Homo sapiens_hsa049761.63502973
21Sulfur metabolism_Homo sapiens_hsa009201.58820414
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.54587038
23Alzheimers disease_Homo sapiens_hsa050101.51448787
24Allograft rejection_Homo sapiens_hsa053301.45537157
25Glutathione metabolism_Homo sapiens_hsa004801.43183373
26Autoimmune thyroid disease_Homo sapiens_hsa053201.37145997
27Tryptophan metabolism_Homo sapiens_hsa003801.30726458
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.30344756
29Graft-versus-host disease_Homo sapiens_hsa053321.29298310
30Arginine and proline metabolism_Homo sapiens_hsa003301.24431897
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.22020147
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.19581250
33Glycerolipid metabolism_Homo sapiens_hsa005611.19251843
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.18489099
35Staphylococcus aureus infection_Homo sapiens_hsa051501.18416100
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16181665
37Pyruvate metabolism_Homo sapiens_hsa006201.15839058
38Sphingolipid metabolism_Homo sapiens_hsa006001.15675963
39Huntingtons disease_Homo sapiens_hsa050161.11604583
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10944467
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10268497
42Type I diabetes mellitus_Homo sapiens_hsa049401.04670317
43Antigen processing and presentation_Homo sapiens_hsa046121.01939916
44Arginine biosynthesis_Homo sapiens_hsa002200.99560748
45* Intestinal immune network for IgA production_Homo sapiens_hsa046720.97648288
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91716882
47Ribosome_Homo sapiens_hsa030100.90851707
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89272821
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88041875
50Primary immunodeficiency_Homo sapiens_hsa053400.85312778
51Fatty acid degradation_Homo sapiens_hsa000710.82814383
52African trypanosomiasis_Homo sapiens_hsa051430.82221699
53Arachidonic acid metabolism_Homo sapiens_hsa005900.79682616
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75779039
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74760213
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73501244
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.71520825
58Hepatitis C_Homo sapiens_hsa051600.69047332
59beta-Alanine metabolism_Homo sapiens_hsa004100.67691430
60Tight junction_Homo sapiens_hsa045300.62040532
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61213900
62PPAR signaling pathway_Homo sapiens_hsa033200.57777264
63Thyroid hormone synthesis_Homo sapiens_hsa049180.56868148
64Linoleic acid metabolism_Homo sapiens_hsa005910.56836285
65Pancreatic secretion_Homo sapiens_hsa049720.56830732
66Pentose phosphate pathway_Homo sapiens_hsa000300.56260344
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55277569
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55184550
69Carbon metabolism_Homo sapiens_hsa012000.53154251
70ABC transporters_Homo sapiens_hsa020100.52840417
71Homologous recombination_Homo sapiens_hsa034400.52726107
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52562891
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.50864403
74Viral myocarditis_Homo sapiens_hsa054160.50831499
75Influenza A_Homo sapiens_hsa051640.48219498
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47380467
77Peroxisome_Homo sapiens_hsa041460.47317279
78Cardiac muscle contraction_Homo sapiens_hsa042600.46888922
79Retinol metabolism_Homo sapiens_hsa008300.46458296
80Chemical carcinogenesis_Homo sapiens_hsa052040.45848944
81Metabolic pathways_Homo sapiens_hsa011000.44545181
82Nitrogen metabolism_Homo sapiens_hsa009100.42903435
83Fatty acid metabolism_Homo sapiens_hsa012120.42645993
84Gastric acid secretion_Homo sapiens_hsa049710.41180443
85Vibrio cholerae infection_Homo sapiens_hsa051100.41090773
86Lysine degradation_Homo sapiens_hsa003100.38737464
87Renin secretion_Homo sapiens_hsa049240.37712597
88Bladder cancer_Homo sapiens_hsa052190.37500441
89Other glycan degradation_Homo sapiens_hsa005110.37346372
90Pertussis_Homo sapiens_hsa051330.36913385
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34502473
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33801595
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32782382
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.32699186
95Fatty acid biosynthesis_Homo sapiens_hsa000610.30569359
96GnRH signaling pathway_Homo sapiens_hsa049120.29396052
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.29120228
98Tyrosine metabolism_Homo sapiens_hsa003500.28977342
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.28180807
100Ether lipid metabolism_Homo sapiens_hsa005650.27891401
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.27853921
102Insulin resistance_Homo sapiens_hsa049310.25194805
103Type II diabetes mellitus_Homo sapiens_hsa049300.24858585
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.23060296
105Toxoplasmosis_Homo sapiens_hsa051450.22013244
106TNF signaling pathway_Homo sapiens_hsa046680.20639961
107Biosynthesis of amino acids_Homo sapiens_hsa012300.20372259
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.19810668
109Leishmaniasis_Homo sapiens_hsa051400.19757527
110Purine metabolism_Homo sapiens_hsa002300.18918899
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.17010934
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.16816849
113Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.16661741
114Tuberculosis_Homo sapiens_hsa051520.16639109
115Salivary secretion_Homo sapiens_hsa049700.16426654
116Cocaine addiction_Homo sapiens_hsa050300.16282524
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.15059944
118Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.14717324
119Herpes simplex infection_Homo sapiens_hsa051680.13520712
120Legionellosis_Homo sapiens_hsa051340.11405581
121Sulfur relay system_Homo sapiens_hsa041220.11233454
122Apoptosis_Homo sapiens_hsa042100.11228105
123NF-kappa B signaling pathway_Homo sapiens_hsa040640.10979811
124Phenylalanine metabolism_Homo sapiens_hsa003600.09810984
125Glucagon signaling pathway_Homo sapiens_hsa049220.09721225
126Primary bile acid biosynthesis_Homo sapiens_hsa001200.09506202
127Rheumatoid arthritis_Homo sapiens_hsa053230.08730396
128Pyrimidine metabolism_Homo sapiens_hsa002400.08520570
129Hematopoietic cell lineage_Homo sapiens_hsa046400.06708524
130Small cell lung cancer_Homo sapiens_hsa052220.06318785
131Systemic lupus erythematosus_Homo sapiens_hsa053220.06059525
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.04804914
133Insulin secretion_Homo sapiens_hsa049110.04329080
134* Chemokine signaling pathway_Homo sapiens_hsa040620.04109362
135Amphetamine addiction_Homo sapiens_hsa050310.02846711

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