CCL26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for normal peripheral blood eosinophils and basophils. The product of this gene is one of three related chemokines that specifically activate chemokine receptor CCR3. This chemokine may contribute to the eosinophil accumulation in atopic diseases. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of chemokine secretion (GO:0090197)9.52663608
2eosinophil migration (GO:0072677)9.06199423
3regulation of chemokine secretion (GO:0090196)8.46155743
4positive regulation of macrophage activation (GO:0043032)7.70249166
5negative regulation of macrophage differentiation (GO:0045650)6.83595395
6proteasome assembly (GO:0043248)4.81435424
7regulation of gonadotropin secretion (GO:0032276)4.62504982
8adhesion of symbiont to host (GO:0044406)4.52569669
9protein maturation by protein folding (GO:0022417)4.38875942
10regulation of integrin-mediated signaling pathway (GO:2001044)4.37187499
11adhesion of symbiont to host cell (GO:0044650)4.29672933
12virion attachment to host cell (GO:0019062)4.29672933
13endocrine hormone secretion (GO:0060986)4.24236246
14cellular response to follicle-stimulating hormone stimulus (GO:0071372)4.04268705
15positive regulation of SMAD protein import into nucleus (GO:0060391)4.00254637
16positive regulation of mitotic sister chromatid separation (GO:1901970)3.95642202
17positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.95642202
18positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.95642202
19negative regulation of interferon-gamma production (GO:0032689)3.78983685
20regulation of macrophage differentiation (GO:0045649)3.78648986
21histamine secretion (GO:0001821)3.75250337
22pinocytosis (GO:0006907)3.71201920
23positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.69718398
24mesodermal cell differentiation (GO:0048333)3.66682221
25chaperone-mediated protein transport (GO:0072321)3.65317091
26regulation of interleukin-5 production (GO:0032674)3.64261786
27regulation of macrophage activation (GO:0043030)3.59099665
28establishment of integrated proviral latency (GO:0075713)3.57250012
29positive regulation of chromosome segregation (GO:0051984)3.56967317
30mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.55354412
31ribosome assembly (GO:0042255)3.54433925
32negative regulation of axon extension involved in axon guidance (GO:0048843)3.52792600
33negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.52726146
34positive regulation of mast cell activation involved in immune response (GO:0033008)3.48063569
35positive regulation of mast cell degranulation (GO:0043306)3.48063569
36response to follicle-stimulating hormone (GO:0032354)3.43308374
37establishment of protein localization to mitochondrial membrane (GO:0090151)3.40927130
38negative regulation of androgen receptor signaling pathway (GO:0060766)3.37810309
39positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)3.35940861
40negative regulation of ligase activity (GO:0051352)3.29962862
41negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.29962862
42regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.29159732
43polyamine biosynthetic process (GO:0006596)3.25350570
44rRNA modification (GO:0000154)3.19189535
45peptidyl-histidine modification (GO:0018202)3.16163161
46attachment of spindle microtubules to kinetochore (GO:0008608)3.15778762
47positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.13285867
48response to histamine (GO:0034776)3.08082336
49lipopolysaccharide biosynthetic process (GO:0009103)3.07878302
50adenosine receptor signaling pathway (GO:0001973)3.05645168
51IMP biosynthetic process (GO:0006188)3.03429579
52positive regulation of receptor recycling (GO:0001921)3.01267692
53establishment of viral latency (GO:0019043)3.00621128
54protein neddylation (GO:0045116)2.99254716
55regulation of fever generation (GO:0031620)2.99124970
56regulation of SMAD protein import into nucleus (GO:0060390)2.98919909
57positive regulation of prostaglandin secretion (GO:0032308)2.96032541
58regulation of endothelial cell differentiation (GO:0045601)2.95408245
59substrate-dependent cell migration (GO:0006929)2.94365853
60histamine transport (GO:0051608)2.94029851
61anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.93197336
62negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.91447419
63regulation of early endosome to late endosome transport (GO:2000641)2.90828694
64ATP synthesis coupled proton transport (GO:0015986)2.87781775
65energy coupled proton transport, down electrochemical gradient (GO:0015985)2.87781775
66cellular response to zinc ion (GO:0071294)2.87536482
67nucleotide-sugar biosynthetic process (GO:0009226)2.87234193
68UDP-N-acetylglucosamine metabolic process (GO:0006047)2.85665501
69positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517)2.85143998
70hemoglobin metabolic process (GO:0020027)2.83026634
71regulation of cellular amino acid metabolic process (GO:0006521)2.78688812
72nucleobase biosynthetic process (GO:0046112)2.78069627
73negative regulation of axon guidance (GO:1902668)2.77403819
74IMP metabolic process (GO:0046040)2.76827872
75eyelid development in camera-type eye (GO:0061029)2.75787818
76purine nucleobase biosynthetic process (GO:0009113)2.73989098
77positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.73943891
78regulation of clathrin-mediated endocytosis (GO:2000369)2.72403978
79regulation of prostaglandin secretion (GO:0032306)2.71568387
80protein targeting to mitochondrion (GO:0006626)2.69876445
81DNA replication checkpoint (GO:0000076)2.68679610
82positive regulation of actin filament depolymerization (GO:0030836)2.68035520
83platelet dense granule organization (GO:0060155)2.66048656
84regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.65576598
85regulation of ubiquitin-protein transferase activity (GO:0051438)2.63219827
86positive regulation of ligase activity (GO:0051351)2.62977956
87regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.62044696
88regulation of mitotic spindle checkpoint (GO:1903504)2.62044696
89regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.60587093
90regulation of mitotic metaphase/anaphase transition (GO:0030071)2.60587093
91regulation of helicase activity (GO:0051095)2.59587775
92protein localization to chromosome, centromeric region (GO:0071459)2.59492115
93barbed-end actin filament capping (GO:0051016)2.56560379
94AMP metabolic process (GO:0046033)2.56555597
95cell cycle G1/S phase transition (GO:0044843)2.56098327
96G1/S transition of mitotic cell cycle (GO:0000082)2.56098327
97rRNA methylation (GO:0031167)2.55863303
98vitamin A metabolic process (GO:0006776)2.55260362
99DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.55171942
100eosinophil chemotaxis (GO:0048245)10.1379135

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.25607643
2E2F7_22180533_ChIP-Seq_HELA_Human4.58084057
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.45556641
4CREB1_15753290_ChIP-ChIP_HEK293T_Human3.73393979
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.58220380
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.10429686
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.08383473
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.07557081
9ELK1_19687146_ChIP-ChIP_HELA_Human2.96388969
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.82722871
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.74803004
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.52540970
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.35929071
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.34532904
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.31979914
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.27592361
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.27548705
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.24566460
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.23967457
20E2F1_18555785_ChIP-Seq_MESCs_Mouse2.23380908
21VDR_22108803_ChIP-Seq_LS180_Human2.21986892
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.17006971
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.11180329
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.00680537
25NELFA_20434984_ChIP-Seq_ESCs_Mouse1.99266886
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.94639576
27AR_21909140_ChIP-Seq_LNCAP_Human1.93455982
28HOXB4_20404135_ChIP-ChIP_EML_Mouse1.92629959
29VDR_23849224_ChIP-Seq_CD4+_Human1.92308410
30DCP1A_22483619_ChIP-Seq_HELA_Human1.92288399
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.90801626
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.88194120
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86491180
34FOXP3_21729870_ChIP-Seq_TREG_Human1.80393380
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77149079
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.70847396
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.70247584
38ELK1_22589737_ChIP-Seq_MCF10A_Human1.64366153
39HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.63714262
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.62268258
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61139402
42KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.60126410
43KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.60126410
44KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.60126410
45* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.60047709
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.59667855
47SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.57011720
48GABP_19822575_ChIP-Seq_HepG2_Human1.53615873
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.52355926
50TFEB_21752829_ChIP-Seq_HELA_Human1.50883658
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.49079397
52HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.45740052
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45722407
54HIF1A_21447827_ChIP-Seq_MCF-7_Human1.41698186
55TTF2_22483619_ChIP-Seq_HELA_Human1.37453026
56MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.37205541
57FOXM1_23109430_ChIP-Seq_U2OS_Human1.36316385
58NANOG_16153702_ChIP-ChIP_HESCs_Human1.30758836
59ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.29629930
60CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.28897770
61XRN2_22483619_ChIP-Seq_HELA_Human1.28533332
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27315366
63CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.25591958
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25583680
65IRF8_22096565_ChIP-ChIP_GC-B_Human1.25053280
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24655126
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.23365004
68BRD4_25478319_ChIP-Seq_HGPS_Human1.22081849
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19495643
70YY1_21170310_ChIP-Seq_MESCs_Mouse1.18564330
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16318419
72NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14978747
73PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13494718
74FLI1_27457419_Chip-Seq_LIVER_Mouse1.11454995
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08324661
76YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07024362
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06943632
78TRIM28_21343339_ChIP-Seq_HEK293_Human1.02844403
79BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01870176
80CLOCK_20551151_ChIP-Seq_293T_Human1.01791797
81SOX17_20123909_ChIP-Seq_XEN_Mouse1.01644285
82RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99896485
83NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.99266442
84CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98407338
85KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98395376
86NANOG_18692474_ChIP-Seq_MEFs_Mouse0.98330520
87CJUN_26792858_Chip-Seq_BT549_Human0.97073845
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.95737771
89PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95175283
90CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94977768
91TCF3_18692474_ChIP-Seq_MEFs_Mouse0.94492511
92STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92682810
93TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92621202
94FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92606574
95SOX2_16153702_ChIP-ChIP_HESCs_Human0.89053895
96RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.88390644
97MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.85353372
98KLF4_18555785_ChIP-Seq_MESCs_Mouse0.84941160
99SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84374684
100SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.84165476

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose5.00070459
2MP0008438_abnormal_cutaneous_collagen4.31738390
3MP0000343_altered_response_to3.99752774
4MP0005187_abnormal_penis_morphology3.37531027
5MP0003315_abnormal_perineum_morphology3.22065231
6MP0003950_abnormal_plasma_membrane3.18182537
7MP0003011_delayed_dark_adaptation3.04574580
8MP0002295_abnormal_pulmonary_circulatio2.81637423
9MP0004957_abnormal_blastocyst_morpholog2.75703958
10MP0008877_abnormal_DNA_methylation2.70610577
11MP0001299_abnormal_eye_distance/2.68251550
12MP0002254_reproductive_system_inflammat2.36950862
13MP0008932_abnormal_embryonic_tissue2.28092454
14MP0003279_aneurysm2.12966724
15MP0008058_abnormal_DNA_repair2.12738122
16MP0005275_abnormal_skin_tensile2.08097892
17MP0003941_abnormal_skin_development2.07894597
18MP0002277_abnormal_respiratory_mucosa2.05407185
19MP0001986_abnormal_taste_sensitivity1.99875596
20MP0000749_muscle_degeneration1.83359785
21MP0003806_abnormal_nucleotide_metabolis1.82467397
22MP0003718_maternal_effect1.79340434
23MP0003448_altered_tumor_morphology1.78478335
24MP0010368_abnormal_lymphatic_system1.77761623
25MP0003111_abnormal_nucleus_morphology1.76580892
26MP0001542_abnormal_bone_strength1.68159392
27MP0003186_abnormal_redox_activity1.63706883
28MP0001853_heart_inflammation1.62539581
29MP0003693_abnormal_embryo_hatching1.59313926
30MP0008057_abnormal_DNA_replication1.57216688
31MP0006054_spinal_hemorrhage1.55116934
32MP0010352_gastrointestinal_tract_polyps1.50531083
33MP0008007_abnormal_cellular_replicative1.49352773
34MP0005503_abnormal_tendon_morphology1.44583870
35MP0002006_tumorigenesis1.44567645
36MP0003077_abnormal_cell_cycle1.44113196
37MP0010094_abnormal_chromosome_stability1.44023325
38MP0004272_abnormal_basement_membrane1.44001661
39MP0005058_abnormal_lysosome_morphology1.39456456
40MP0003566_abnormal_cell_adhesion1.34795975
41MP0009384_cardiac_valve_regurgitation1.31561216
42MP0010307_abnormal_tumor_latency1.27359393
43MP0001881_abnormal_mammary_gland1.26963468
44MP0006036_abnormal_mitochondrial_physio1.26752252
45MP0002796_impaired_skin_barrier1.24491510
46MP0002877_abnormal_melanocyte_morpholog1.23663771
47MP0001727_abnormal_embryo_implantation1.23658981
48MP0003136_yellow_coat_color1.21049565
49MP0002396_abnormal_hematopoietic_system1.19817394
50MP0002009_preneoplasia1.12535679
51MP0008775_abnormal_heart_ventricle1.11924861
52MP0001915_intracranial_hemorrhage1.11818111
53MP0001879_abnormal_lymphatic_vessel1.10219863
54MP0010030_abnormal_orbit_morphology1.09619001
55MP0004215_abnormal_myocardial_fiber1.09343913
56MP0008004_abnormal_stomach_pH1.08065989
57MP0002060_abnormal_skin_morphology1.00759357
58MP0005666_abnormal_adipose_tissue0.99746860
59MP0003786_premature_aging0.96590167
60MP0005257_abnormal_intraocular_pressure0.93474555
61MP0005508_abnormal_skeleton_morphology0.91944557
62MP0002085_abnormal_embryonic_tissue0.91811876
63MP0005171_absent_coat_pigmentation0.89769131
64MP0003567_abnormal_fetal_cardiomyocyte0.89647385
65MP0002148_abnormal_hypersensitivity_rea0.88913369
66MP0002751_abnormal_autonomic_nervous0.88276361
67MP0000350_abnormal_cell_proliferation0.87878728
68MP0004019_abnormal_vitamin_homeostasis0.86284454
69MP0009672_abnormal_birth_weight0.86277421
70MP0000432_abnormal_head_morphology0.85812409
71MP0003890_abnormal_embryonic-extraembry0.85623287
72MP0000627_abnormal_mammary_gland0.80356450
73MP0009053_abnormal_anal_canal0.80069923
74MP0003705_abnormal_hypodermis_morpholog0.79922406
75MP0001730_embryonic_growth_arrest0.77622918
76MP0000858_altered_metastatic_potential0.76188059
77MP0000358_abnormal_cell_content/0.72337334
78MP0003936_abnormal_reproductive_system0.71919846
79MP0002084_abnormal_developmental_patter0.71276259
80MP0005165_increased_susceptibility_to0.70793535
81MP0002998_abnormal_bone_remodeling0.69205757
82MP0005174_abnormal_tail_pigmentation0.68620914
83MP0009250_abnormal_appendicular_skeleto0.68450641
84MP0002090_abnormal_vision0.67616500
85MP0001697_abnormal_embryo_size0.66698480
86MP0009333_abnormal_splenocyte_physiolog0.66448148
87MP0002080_prenatal_lethality0.64891152
88MP0005193_abnormal_anterior_eye0.64881052
89MP0005395_other_phenotype0.64360626
90MP0001545_abnormal_hematopoietic_system0.64202999
91MP0005397_hematopoietic_system_phenotyp0.64202999
92MP0005380_embryogenesis_phenotype0.63719792
93MP0001672_abnormal_embryogenesis/_devel0.63719792
94MP0005584_abnormal_enzyme/coenzyme_acti0.63718409
95MP0002086_abnormal_extraembryonic_tissu0.63641572
96MP0009697_abnormal_copulation0.63240834
97MP0003300_gastrointestinal_ulcer0.62812098
98MP0006072_abnormal_retinal_apoptosis0.61961652
99MP0009703_decreased_birth_body0.61943358
100MP0003699_abnormal_female_reproductive0.57767884

Predicted human phenotypes

RankGene SetZ-score
1Spontaneous hematomas (HP:0007420)7.14923889
2Osteolytic defects of the phalanges of the hand (HP:0009771)5.58606290
3Osteolytic defects of the hand bones (HP:0009699)5.58606290
4Follicular hyperkeratosis (HP:0007502)4.92875542
5Thick nail (HP:0001805)4.88055892
6Joint hemorrhage (HP:0005261)4.61791334
7Pustule (HP:0200039)4.03177238
8Tetraparesis (HP:0002273)3.94351164
9Acute necrotizing encephalopathy (HP:0006965)3.80724767
10Nuclear cataract (HP:0100018)3.77109469
11Axonal loss (HP:0003447)3.71049404
12Vertebral compression fractures (HP:0002953)3.64380023
13Recurrent bacterial skin infections (HP:0005406)3.60475967
14Systemic lupus erythematosus (HP:0002725)3.49277593
15Abnormality of the common coagulation pathway (HP:0010990)3.45325358
16Premature loss of primary teeth (HP:0006323)3.33544996
17Abnormal mitochondria in muscle tissue (HP:0008316)3.31118720
18Progressive macrocephaly (HP:0004481)3.22453651
19Premature rupture of membranes (HP:0001788)3.20236684
20Vacuolated lymphocytes (HP:0001922)3.15015181
21Periodontitis (HP:0000704)3.13610807
22Type I transferrin isoform profile (HP:0003642)3.13481902
23Agnosia (HP:0010524)3.08999455
24Abnormal protein glycosylation (HP:0012346)3.06568203
25Abnormal glycosylation (HP:0012345)3.06568203
26Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.06568203
27Abnormal protein N-linked glycosylation (HP:0012347)3.06568203
28Reduced antithrombin III activity (HP:0001976)3.04796320
29Hydroxyprolinuria (HP:0003080)2.96456268
30Abnormality of proline metabolism (HP:0010907)2.96456268
31Acute encephalopathy (HP:0006846)2.96419776
32Abnormal trabecular bone morphology (HP:0100671)2.93422535
33Zonular cataract (HP:0010920)2.93097181
34Alopecia of scalp (HP:0002293)2.85861647
35Abnormality of methionine metabolism (HP:0010901)2.81738314
36Upper motor neuron abnormality (HP:0002127)2.79745605
37Recurrent abscess formation (HP:0002722)2.78446664
38Mutism (HP:0002300)2.71747267
39Abnormality of the alveolar ridges (HP:0006477)2.71129278
40Cerebral edema (HP:0002181)2.59418545
41Renal Fanconi syndrome (HP:0001994)2.54542672
42Sparse eyelashes (HP:0000653)2.53429956
43Birth length less than 3rd percentile (HP:0003561)2.51428071
44Abnormality of the umbilical cord (HP:0010881)2.49023883
45Abnormality of the fetal cardiovascular system (HP:0010948)2.46629808
46Abnormal umbilical cord blood vessels (HP:0011403)2.46629808
47Single umbilical artery (HP:0001195)2.46629808
48Increased CSF lactate (HP:0002490)2.46089921
49Sensory axonal neuropathy (HP:0003390)2.39900980
50Abnormal gallbladder physiology (HP:0012438)2.34184130
51Cholecystitis (HP:0001082)2.34184130
52Redundant skin (HP:0001582)2.31819240
53Mitochondrial inheritance (HP:0001427)2.29740638
54Aplastic anemia (HP:0001915)2.29302134
55Corneal dystrophy (HP:0001131)2.22897889
56Rough bone trabeculation (HP:0100670)2.20737425
57Glomerulonephritis (HP:0000099)2.20198998
58Gingival overgrowth (HP:0000212)2.19700147
59Abnormality of aspartate family amino acid metabolism (HP:0010899)2.19377553
60Melanoma (HP:0002861)2.18464491
61Dysostosis multiplex (HP:0000943)2.17897004
62Abnormality of sulfur amino acid metabolism (HP:0004339)2.15964651
63Leukodystrophy (HP:0002415)2.10765070
64Gingivitis (HP:0000230)2.03715107
65Decreased electroretinogram (ERG) amplitude (HP:0000654)1.95234896
66Increased serum pyruvate (HP:0003542)1.94316656
67Short middle phalanx of the 5th finger (HP:0004220)1.92380433
68Increased hepatocellular lipid droplets (HP:0006565)1.91118781
69Abnormality of glycolysis (HP:0004366)1.91050888
70Hypoalphalipoproteinemia (HP:0003233)1.89436257
71Exertional dyspnea (HP:0002875)1.88123606
72Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.87005918
73Decreased activity of mitochondrial respiratory chain (HP:0008972)1.87005918
74Abnormality of the intrinsic pathway (HP:0010989)1.86896782
75Spastic paraparesis (HP:0002313)1.84890371
76Palmoplantar hyperkeratosis (HP:0000972)1.83382227
77Palmar hyperkeratosis (HP:0010765)1.82705338
78Protrusio acetabuli (HP:0003179)1.82044934
79Basal ganglia calcification (HP:0002135)1.80072956
80Paraparesis (HP:0002385)1.78169939
81Bone cyst (HP:0012062)1.76421019
82Colon cancer (HP:0003003)1.72430058
83Testicular atrophy (HP:0000029)1.72000335
84Patchy hypopigmentation of hair (HP:0011365)1.71948363
85Bifid tongue (HP:0010297)1.71224743
86Breech presentation (HP:0001623)1.71009823
87Exercise intolerance (HP:0003546)1.68877454
88Nausea (HP:0002018)1.68556268
89Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.67154655
90Abnormality of the labia minora (HP:0012880)1.66950906
91Neoplasm of the adrenal gland (HP:0100631)1.63720242
92Disinhibition (HP:0000734)1.63262704
93Delayed gross motor development (HP:0002194)1.63126750
94Megaloblastic anemia (HP:0001889)1.61680932
95Hypokinesia (HP:0002375)1.61669179
96Abnormality of mucopolysaccharide metabolism (HP:0011020)1.61561355
97Abnormality of polysaccharide metabolism (HP:0011012)1.61561355
98Abnormality of glycosaminoglycan metabolism (HP:0004371)1.61561355
99Hypolipoproteinemia (HP:0010981)1.60773527
100Cerebral hemorrhage (HP:0001342)1.59957297

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CLK14.67585679
2BUB14.30915441
3PBK3.70853931
4INSRR3.25377205
5VRK22.83869004
6NME22.81146741
7STK162.66936235
8TSSK62.51252317
9TTK2.27032521
10PLK32.09133910
11PAK42.06936319
12MST42.02454923
13CDK191.99838611
14MAP3K121.94971035
15EIF2AK11.94397882
16SRPK11.82567099
17MYLK1.78841357
18EIF2AK31.72615521
19BMPR21.65402713
20CDK91.65352937
21BCKDK1.63602827
22CDK61.58204274
23MUSK1.55928798
24TGFBR21.50908224
25NEK11.37260594
26MKNK21.32562179
27LATS21.29335182
28CDC71.29116009
29BRAF1.26325295
30ABL21.26129004
31TNIK1.21152470
32STK31.14603222
33STK41.12347042
34ARAF1.10331604
35LIMK11.09024701
36MAP4K21.05312812
37PLK11.04161738
38PLK21.02955316
39MKNK10.99896521
40MAP3K80.97929865
41CDK30.97381336
42ADRBK10.97112149
43PDK20.96585867
44CHEK20.93101079
45STK38L0.90986344
46VRK10.88942294
47TRIM280.88474265
48MAP3K30.85071233
49TESK10.84816131
50TAOK20.84524970
51PLK40.82989628
52ILK0.81403781
53ERN10.80331927
54PAK20.78696201
55CAMK1D0.73958151
56DAPK10.73349992
57MST1R0.72313742
58TESK20.72147955
59OXSR10.71816600
60BMPR1B0.69239698
61NME10.68993767
62AURKB0.66897914
63NUAK10.66382917
64SCYL20.65147645
65TAF10.63561648
66BRSK20.62841252
67MAPKAPK50.62355336
68DYRK20.62257991
69PAK10.60583732
70ERBB40.59922330
71STK100.55578621
72CSNK2A10.55316762
73TYK20.53879121
74GRK10.53606121
75CSNK2A20.53597929
76RAF10.49086277
77PRPF4B0.48841563
78CAMK1G0.47580370
79TEC0.47430914
80TGFBR10.47299906
81ALK0.46205961
82PRKCG0.45093411
83KSR20.44906061
84MOS0.44312285
85CDK180.44060823
86BRSK10.43881386
87CDK150.41429303
88DDR20.41025980
89CHEK10.40983465
90NEK60.40975888
91SIK30.40826986
92PRKCE0.39346363
93MAP3K90.38275175
94CDK11A0.36623134
95AURKA0.35445694
96PRKCI0.35225030
97SMG10.33512861
98AKT30.33494884
99DAPK30.33154222
100ZAK0.33092354

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.82390310
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.43689367
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.07173469
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.95247365
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.87091072
6Oxidative phosphorylation_Homo sapiens_hsa001902.79711240
7RNA polymerase_Homo sapiens_hsa030202.76714491
8DNA replication_Homo sapiens_hsa030302.60990097
9Mismatch repair_Homo sapiens_hsa034302.54501581
10Protein export_Homo sapiens_hsa030602.30733648
11Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.26902314
12Parkinsons disease_Homo sapiens_hsa050122.22418612
13Ribosome_Homo sapiens_hsa030102.21626696
14Basal transcription factors_Homo sapiens_hsa030222.07080138
15Cysteine and methionine metabolism_Homo sapiens_hsa002702.06240521
16Non-homologous end-joining_Homo sapiens_hsa034502.05229500
17Huntingtons disease_Homo sapiens_hsa050161.99393637
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.95335216
19Galactose metabolism_Homo sapiens_hsa000521.74588881
20Base excision repair_Homo sapiens_hsa034101.71921156
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.69494569
22Nucleotide excision repair_Homo sapiens_hsa034201.68483828
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.63863448
24One carbon pool by folate_Homo sapiens_hsa006701.61330757
25Lysosome_Homo sapiens_hsa041421.59225887
26Homologous recombination_Homo sapiens_hsa034401.56493202
27Pyrimidine metabolism_Homo sapiens_hsa002401.53949863
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.52359877
29Alzheimers disease_Homo sapiens_hsa050101.49607219
30Glutathione metabolism_Homo sapiens_hsa004801.48232712
31N-Glycan biosynthesis_Homo sapiens_hsa005101.45758570
32RNA transport_Homo sapiens_hsa030131.42159999
33Complement and coagulation cascades_Homo sapiens_hsa046101.32139355
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26010514
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.25220921
36Vitamin B6 metabolism_Homo sapiens_hsa007501.24224391
37Pyruvate metabolism_Homo sapiens_hsa006201.18844989
38Cell cycle_Homo sapiens_hsa041101.11427783
39Biosynthesis of amino acids_Homo sapiens_hsa012301.10775711
40Purine metabolism_Homo sapiens_hsa002301.09968516
41Carbon metabolism_Homo sapiens_hsa012001.06854417
42Sulfur metabolism_Homo sapiens_hsa009201.05430844
43Spliceosome_Homo sapiens_hsa030401.03049958
44Mineral absorption_Homo sapiens_hsa049780.99476626
45Arginine and proline metabolism_Homo sapiens_hsa003300.96139353
46Collecting duct acid secretion_Homo sapiens_hsa049660.93628022
47RNA degradation_Homo sapiens_hsa030180.89582015
48Selenocompound metabolism_Homo sapiens_hsa004500.85802284
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83664276
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80199043
51Pentose phosphate pathway_Homo sapiens_hsa000300.79520364
52Vibrio cholerae infection_Homo sapiens_hsa051100.79146617
53p53 signaling pathway_Homo sapiens_hsa041150.77347045
54Metabolic pathways_Homo sapiens_hsa011000.76771128
55Folate biosynthesis_Homo sapiens_hsa007900.72951744
56TGF-beta signaling pathway_Homo sapiens_hsa043500.72229555
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71671256
58Other glycan degradation_Homo sapiens_hsa005110.70357425
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70070063
60Vitamin digestion and absorption_Homo sapiens_hsa049770.67838381
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66705371
62Fatty acid elongation_Homo sapiens_hsa000620.66207799
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65977652
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63680101
65* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57281844
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56116827
67Propanoate metabolism_Homo sapiens_hsa006400.53575161
68Fat digestion and absorption_Homo sapiens_hsa049750.47882280
69Melanoma_Homo sapiens_hsa052180.44598866
70HIF-1 signaling pathway_Homo sapiens_hsa040660.44044333
71Phagosome_Homo sapiens_hsa041450.42621328
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42208244
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.40478180
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39066270
75Steroid biosynthesis_Homo sapiens_hsa001000.38145429
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37498330
77Sulfur relay system_Homo sapiens_hsa041220.35943371
78Legionellosis_Homo sapiens_hsa051340.35204499
79Rheumatoid arthritis_Homo sapiens_hsa053230.33086709
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31556659
81Oocyte meiosis_Homo sapiens_hsa041140.31462335
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31191525
83Thyroid cancer_Homo sapiens_hsa052160.31026559
84Synaptic vesicle cycle_Homo sapiens_hsa047210.30431800
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28603819
86Fructose and mannose metabolism_Homo sapiens_hsa000510.27012504
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.24345153
88Wnt signaling pathway_Homo sapiens_hsa043100.23125054
89Cardiac muscle contraction_Homo sapiens_hsa042600.22766650
90Sphingolipid metabolism_Homo sapiens_hsa006000.22494445
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.21530316
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19488167
93Prion diseases_Homo sapiens_hsa050200.18782264
94Apoptosis_Homo sapiens_hsa042100.18473202
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.18445334
96Starch and sucrose metabolism_Homo sapiens_hsa005000.18403457
97Fanconi anemia pathway_Homo sapiens_hsa034600.18108297
98Epstein-Barr virus infection_Homo sapiens_hsa051690.17113282
99Proteoglycans in cancer_Homo sapiens_hsa052050.16979199
100Pertussis_Homo sapiens_hsa051330.16872617

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