CCL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of chemokine biosynthetic process (GO:0045080)6.67615690
2response to peptidoglycan (GO:0032494)6.09793062
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.92630275
4positive regulation by organism of defense response of other organism involved in symbiotic interact5.92630275
5modulation by symbiont of host immune response (GO:0052553)5.92630275
6positive regulation by symbiont of host defense response (GO:0052509)5.92630275
7modulation by symbiont of host defense response (GO:0052031)5.92630275
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.92630275
9positive regulation of heat generation (GO:0031652)5.68498782
10regulation of fever generation (GO:0031620)5.65555027
11regulation of chemokine biosynthetic process (GO:0045073)5.51808619
12regulation of T-helper 1 cell differentiation (GO:0045625)5.31027955
13neutrophil activation involved in immune response (GO:0002283)5.17684243
14positive regulation of heterotypic cell-cell adhesion (GO:0034116)5.16515774
15positive regulation of interleukin-8 biosynthetic process (GO:0045416)5.15715685
16regulation of podosome assembly (GO:0071801)4.95659437
17* lipopolysaccharide-mediated signaling pathway (GO:0031663)4.79390650
18positive regulation of inflammatory response to antigenic stimulus (GO:0002863)4.76534577
19regulation of cytokine secretion involved in immune response (GO:0002739)4.66767954
20positive regulation of interferon-alpha production (GO:0032727)4.59105187
21regulation of vitamin D biosynthetic process (GO:0060556)4.58666836
22regulation of interferon-alpha production (GO:0032647)4.47302665
23macrophage activation involved in immune response (GO:0002281)4.47008689
24regulation of heat generation (GO:0031650)4.35705731
25regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.32090223
26respiratory burst (GO:0045730)4.31350308
27regulation of mononuclear cell migration (GO:0071675)4.29540604
28hydrogen peroxide biosynthetic process (GO:0050665)4.24305065
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.21232296
30regulation of chronic inflammatory response (GO:0002676)4.18697854
31cytidine metabolic process (GO:0046087)4.16175729
32cytidine catabolic process (GO:0006216)4.16175729
33cytidine deamination (GO:0009972)4.16175729
34regulation of vitamin metabolic process (GO:0030656)4.06564911
35negative regulation of cytokine production involved in immune response (GO:0002719)3.99076604
36NIK/NF-kappaB signaling (GO:0038061)3.98845614
37response to type I interferon (GO:0034340)3.98282999
38response to muramyl dipeptide (GO:0032495)3.95110288
39superoxide anion generation (GO:0042554)3.94243588
40regulation of heterotypic cell-cell adhesion (GO:0034114)3.87466318
41response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.85683800
42response to host immune response (GO:0052572)3.85683800
43regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.84978301
44positive regulation of NF-kappaB import into nucleus (GO:0042346)3.84362893
45immunoglobulin mediated immune response (GO:0016064)3.79984283
46positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.79121031
47positive regulation of gamma-delta T cell activation (GO:0046645)3.78345135
48reactive oxygen species biosynthetic process (GO:1903409)3.75596791
49activation of MAPKKK activity (GO:0000185)3.75095497
50negative regulation of amino acid transport (GO:0051956)3.73941263
51pyrimidine ribonucleoside catabolic process (GO:0046133)3.72722087
52regulation of immunoglobulin secretion (GO:0051023)3.72645944
53regulation of interleukin-8 biosynthetic process (GO:0045414)3.72462647
54positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.72246736
55positive regulation of immunoglobulin mediated immune response (GO:0002891)3.69651119
56positive regulation of B cell mediated immunity (GO:0002714)3.69651119
57positive regulation of humoral immune response (GO:0002922)3.67515677
58cellular response to interferon-beta (GO:0035458)3.62241269
59regulation of membrane protein ectodomain proteolysis (GO:0051043)3.58717287
60regulation of interferon-beta biosynthetic process (GO:0045357)3.58086028
61microglial cell activation (GO:0001774)3.57284923
62negative regulation of interleukin-17 production (GO:0032700)3.56284892
63positive regulation of chemokine production (GO:0032722)3.56201763
64negative regulation of growth of symbiont in host (GO:0044130)3.51697969
65negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.51697969
66modulation of growth of symbiont involved in interaction with host (GO:0044144)3.51697969
67regulation of growth of symbiont in host (GO:0044126)3.51697969
68negative regulation of viral genome replication (GO:0045071)3.49502371
69positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.49331464
70macrophage activation (GO:0042116)3.47919899
71cellular response to nicotine (GO:0071316)3.47720613
72positive regulation of nitric oxide biosynthetic process (GO:0045429)3.46034943
73negative regulation of nitric oxide biosynthetic process (GO:0045019)3.45300651
74positive regulation of mast cell degranulation (GO:0043306)3.44430429
75positive regulation of mast cell activation involved in immune response (GO:0033008)3.44430429
76defense response to protozoan (GO:0042832)3.44261638
77myeloid dendritic cell activation (GO:0001773)3.43416257
78regulation of interleukin-17 production (GO:0032660)3.42273090
79branching involved in labyrinthine layer morphogenesis (GO:0060670)3.41647066
80regulation of interleukin-2 biosynthetic process (GO:0045076)3.40870775
81response to host (GO:0075136)3.40309600
82response to host defenses (GO:0052200)3.40309600
83response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.40309600
84positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.39815847
85positive regulation of defense response to virus by host (GO:0002230)3.39584251
86positive regulation of alpha-beta T cell proliferation (GO:0046641)3.38720975
87interferon-gamma-mediated signaling pathway (GO:0060333)3.37781025
88positive regulation of interferon-beta production (GO:0032728)3.36191614
89regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.35284912
90myeloid dendritic cell differentiation (GO:0043011)3.32915601
91leukocyte aggregation (GO:0070486)3.32256658
92response to interferon-beta (GO:0035456)3.28733657
93cellular response to exogenous dsRNA (GO:0071360)3.27941003
94regulation of T-helper 1 type immune response (GO:0002825)3.27214997
95positive regulation of lymphocyte apoptotic process (GO:0070230)3.26377285
96T-helper 1 type immune response (GO:0042088)3.25600126
97* granulocyte activation (GO:0036230)3.25190795
98regulation of interleukin-12 production (GO:0032655)3.23107395
99neutrophil activation (GO:0042119)3.22498139
100* monocyte chemotaxis (GO:0002548)3.21602966
101negative regulation of production of molecular mediator of immune response (GO:0002701)3.21558606
102positive regulation of interleukin-12 production (GO:0032735)3.21314855
103positive regulation of interleukin-6 production (GO:0032755)3.20856626
104negative regulation of myeloid cell apoptotic process (GO:0033033)3.19836451
105positive regulation of cytokine biosynthetic process (GO:0042108)3.19469048
106positive regulation of interleukin-17 production (GO:0032740)3.18839194
107negative regulation of interleukin-12 production (GO:0032695)3.18493305
108regulation of nitric oxide biosynthetic process (GO:0045428)3.17100924
109germinal center formation (GO:0002467)3.15196402
110positive regulation of T cell cytokine production (GO:0002726)3.14028492
111detection of molecule of bacterial origin (GO:0032490)3.13667596
112positive regulation of T-helper 1 type immune response (GO:0002827)3.11168248
113* myeloid cell activation involved in immune response (GO:0002275)3.11160984
114positive regulation of interleukin-10 production (GO:0032733)3.10765336
115positive regulation of type 2 immune response (GO:0002830)3.10295152
116regulation of interleukin-12 biosynthetic process (GO:0045075)3.09581460
117type I interferon signaling pathway (GO:0060337)3.09466586
118cellular response to type I interferon (GO:0071357)3.09466586
119* positive regulation of lymphocyte migration (GO:2000403)3.09384321
120positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.08957823
121response to protozoan (GO:0001562)3.08423031
122positive regulation of acute inflammatory response (GO:0002675)3.07044994
123* regulation of lymphocyte chemotaxis (GO:1901623)3.01399862
124* cellular response to lipopolysaccharide (GO:0071222)2.99108777
125regulation of T cell tolerance induction (GO:0002664)2.99100221
126regulation of NF-kappaB import into nucleus (GO:0042345)2.96126302
127positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.95747716
128regulation of inflammatory response to antigenic stimulus (GO:0002861)2.94632335
129regulation of viral genome replication (GO:0045069)2.91584936
130CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.90870302
131B cell mediated immunity (GO:0019724)2.89197722
132positive regulation of monocyte chemotaxis (GO:0090026)2.87381189
133* cellular response to molecule of bacterial origin (GO:0071219)2.87000638
134regulation of T-helper cell differentiation (GO:0045622)2.84852000
135dendritic cell differentiation (GO:0097028)2.84725461
136DNA deamination (GO:0045006)2.81340711
137negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.81125390
138negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.80237764
139regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.79692489
140negative regulation of lipid storage (GO:0010888)2.78889223
141* negative regulation of viral process (GO:0048525)2.77929342
142positive regulation of leukocyte apoptotic process (GO:2000108)2.77820411
143positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.76367829
144* cellular response to interferon-gamma (GO:0071346)2.76347772
145oligosaccharide catabolic process (GO:0009313)2.69617973
146positive regulation of interferon-gamma production (GO:0032729)2.68437216

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse7.14755972
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.77464093
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.29749958
4* IRF8_27001747_Chip-Seq_BMDM_Mouse4.27931155
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.96530868
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.95343357
7RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.62654053
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.59131435
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.57953077
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.50272532
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.21159065
12* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.00107184
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.80387861
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.70662969
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.63820285
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.56448154
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.55097127
18* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.06074650
19BP1_19119308_ChIP-ChIP_Hs578T_Human10.6739388
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.90761058
21SPI1_23547873_ChIP-Seq_NB4_Human1.87780148
22* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.81240932
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.76224340
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.65754754
25CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.64509640
26* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.64431233
27* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.63195558
28* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.59834733
29VDR_24763502_ChIP-Seq_THP-1_Human1.59357547
30* VDR_24787735_ChIP-Seq_THP-1_Human1.58310281
31PU_27001747_Chip-Seq_BMDM_Mouse1.58300468
32* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.53001091
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.48108599
34* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.40684377
35MYB_26560356_Chip-Seq_TH2_Human1.39711008
36SCL_19346495_ChIP-Seq_HPC-7_Human1.36551507
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.34689484
38CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34220810
39RUNX_20019798_ChIP-Seq_JUKART_Human1.30854593
40TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.27310504
41SPI1_23127762_ChIP-Seq_K562_Human1.27222574
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26126264
43* MAF_26560356_Chip-Seq_TH2_Human1.24794864
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.23617139
45PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22830901
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20758372
47* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18510541
48MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15826990
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13193997
50* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10252237
51GATA3_27048872_Chip-Seq_THYMUS_Human1.09945715
52SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09483992
53MAF_26560356_Chip-Seq_TH1_Human1.09460041
54GATA3_26560356_Chip-Seq_TH2_Human1.08633055
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07241922
56* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06956984
57* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.04717000
58EGR1_19032775_ChIP-ChIP_M12_Human1.04189038
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03443203
60MYB_26560356_Chip-Seq_TH1_Human1.01651207
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00914534
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00738203
63NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00738203
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99699439
65STAT1_20625510_ChIP-Seq_HELA_Human0.99484852
66GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98866685
67GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96984117
68* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96567343
69CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94754860
70NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.93283467
71LXR_22292898_ChIP-Seq_THP-1_Human0.92379628
72VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92045589
73NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91532460
74GATA2_21666600_ChIP-Seq_HMVEC_Human0.91251151
75SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.90967900
76KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90805222
77KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.90805222
78KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90805222
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.89839229
80KDM2B_26808549_Chip-Seq_DND41_Human0.89450058
81TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88451195
82MYC_22102868_ChIP-Seq_BL_Human0.87518846
83GATA1_19941827_ChIP-Seq_MEL_Mouse0.85433543
84ESR2_21235772_ChIP-Seq_MCF-7_Human0.84809313
85TFEB_21752829_ChIP-Seq_HELA_Human0.84499694
86E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.83839868
87PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.83720137
88BCL6_27268052_Chip-Seq_Bcells_Human0.83701796
89CDX2_19796622_ChIP-Seq_MESCs_Mouse0.80543891
90BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78518348
91UTX_26944678_Chip-Seq_JUKART_Human0.78041974
92GATA1_19941826_ChIP-Seq_K562_Human0.77773194
93BCOR_27268052_Chip-Seq_Bcells_Human0.76173939
94EGR1_23403033_ChIP-Seq_LIVER_Mouse0.76116185
95ELF1_20517297_ChIP-Seq_JURKAT_Human0.76001515
96SOX2_20726797_ChIP-Seq_SW620_Human0.75256213
97KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.74998928
98TCF7_22412390_ChIP-Seq_EML_Mouse0.74344214
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73518074
100VDR_21846776_ChIP-Seq_THP-1_Human0.72706133
101CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.72499270
102SPI1_20517297_ChIP-Seq_HL60_Human0.70952770
103JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.70937557
104CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.69870828
105SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64346021
106* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.64237633
107JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.63903639
108CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.63797213
109CJUN_26792858_Chip-Seq_BT549_Human0.63661351
110FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.62095838
111TP63_17297297_ChIP-ChIP_HaCaT_Human0.60333502
112ELK3_25401928_ChIP-Seq_HUVEC_Human0.59474179
113GATA1_22025678_ChIP-Seq_K562_Human0.57512562
114NOTCH1_21737748_ChIP-Seq_TLL_Human0.57484139
115P63_26484246_Chip-Seq_KERATINOCYTES_Human0.56003064
116GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.55622965
117CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.54998196
118* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.54714593
119SRY_22984422_ChIP-ChIP_TESTIS_Rat0.54692896
120GATA2_19941826_ChIP-Seq_K562_Human0.53809580
121TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.53412185
122SALL4_18804426_ChIP-ChIP_XEN_Mouse0.53389573
123SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.53115470
124SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.53115470

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009785_altered_susceptibility_to4.81455442
2MP0003436_decreased_susceptibility_to4.57359051
3MP0001835_abnormal_antigen_presentation4.25639906
4* MP0002148_abnormal_hypersensitivity_rea3.99147152
5* MP0006082_CNS_inflammation3.94115858
6MP0003303_peritoneal_inflammation3.87814866
7MP0003724_increased_susceptibility_to3.65159026
8MP0005000_abnormal_immune_tolerance3.61231123
9MP0002419_abnormal_innate_immunity3.45207654
10* MP0005025_abnormal_response_to3.21307029
11MP0005671_abnormal_response_to2.90359895
12MP0009764_decreased_sensitivity_to2.65484402
13MP0002452_abnormal_antigen_presenting2.60986923
14* MP0002723_abnormal_immune_serum2.57914669
15MP0001533_abnormal_skeleton_physiology2.56936816
16MP0001800_abnormal_humoral_immune2.49171830
17MP0001853_heart_inflammation2.41856376
18MP0001790_abnormal_immune_system2.41259378
19MP0005387_immune_system_phenotype2.41259378
20MP0002139_abnormal_hepatobiliary_system2.40885839
21MP0004510_myositis2.34195011
22MP0004947_skin_inflammation2.22301115
23MP0000685_abnormal_immune_system2.17543276
24MP0001819_abnormal_immune_cell2.17473898
25MP0002420_abnormal_adaptive_immunity2.14872967
26MP0005058_abnormal_lysosome_morphology2.12800071
27MP0005464_abnormal_platelet_physiology2.11038552
28MP0002405_respiratory_system_inflammati2.03109557
29MP0001845_abnormal_inflammatory_respons1.98407803
30MP0002006_tumorigenesis1.96175786
31MP0003075_altered_response_to1.95049861
32MP0000343_altered_response_to1.91359308
33* MP0008469_abnormal_protein_level1.86419833
34MP0009333_abnormal_splenocyte_physiolog1.81057697
35MP0003806_abnormal_nucleotide_metabolis1.79277687
36MP0003448_altered_tumor_morphology1.76413845
37MP0006054_spinal_hemorrhage1.71635713
38MP0010155_abnormal_intestine_physiology1.66955184
39MP0005166_decreased_susceptibility_to1.59064437
40MP0002998_abnormal_bone_remodeling1.57726303
41MP0009278_abnormal_bone_marrow1.56972482
42MP0001501_abnormal_sleep_pattern1.45138330
43MP0005164_abnormal_response_to1.44820961
44* MP0000716_abnormal_immune_system1.40805320
45MP0003690_abnormal_glial_cell1.39991251
46MP0003195_calcinosis1.34454320
47MP0000858_altered_metastatic_potential1.34447194
48MP0003172_abnormal_lysosome_physiology1.34375024
49MP0003186_abnormal_redox_activity1.31799738
50MP0005167_abnormal_blood-brain_barrier1.30941884
51MP0002398_abnormal_bone_marrow1.30796815
52MP0003828_pulmonary_edema1.29137112
53MP0001851_eye_inflammation1.26289624
54MP0002138_abnormal_hepatobiliary_system1.25110572
55MP0000604_amyloidosis1.24913006
56MP0009840_abnormal_foam_cell1.24811280
57MP0005390_skeleton_phenotype1.21398678
58MP0005310_abnormal_salivary_gland1.16354619
59MP0000689_abnormal_spleen_morphology1.13178897
60MP0003300_gastrointestinal_ulcer1.12286931
61MP0008004_abnormal_stomach_pH1.11996316
62* MP0002429_abnormal_blood_cell1.10862290
63MP0003453_abnormal_keratinocyte_physiol1.08005454
64MP0001873_stomach_inflammation1.05100288
65MP0002933_joint_inflammation1.01849611
66MP0002332_abnormal_exercise_endurance1.00924183
67MP0002722_abnormal_immune_system1.00695051
68MP0009763_increased_sensitivity_to1.00517643
69MP0001545_abnormal_hematopoietic_system0.99272672
70MP0005397_hematopoietic_system_phenotyp0.99272672
71MP0002877_abnormal_melanocyte_morpholog0.99249682
72MP0004782_abnormal_surfactant_physiolog0.95522256
73MP0003646_muscle_fatigue0.92002428
74MP0003191_abnormal_cellular_cholesterol0.91550252
75MP0001542_abnormal_bone_strength0.91166989
76MP0002277_abnormal_respiratory_mucosa0.88706568
77MP0005165_increased_susceptibility_to0.80840431
78MP0000920_abnormal_myelination0.80792465
79MP0002254_reproductive_system_inflammat0.80159077
80MP0000249_abnormal_blood_vessel0.79328716
81MP0004858_abnormal_nervous_system0.74524967
82MP0005647_abnormal_sex_gland0.74204990
83MP0004883_abnormal_blood_vessel0.73740145
84MP0003329_amyloid_beta_deposits0.73526997
85MP0010352_gastrointestinal_tract_polyps0.71407714
86MP0005535_abnormal_body_temperature0.69932383
87MP0001727_abnormal_embryo_implantation0.69484253
88MP0001958_emphysema0.67229374
89MP0008874_decreased_physiological_sensi0.66642906
90MP0003795_abnormal_bone_structure0.66615971
91MP0003045_fibrosis0.64523925
92MP0003656_abnormal_erythrocyte_physiolo0.64000187
93MP0002166_altered_tumor_susceptibility0.62628596
94MP0003183_abnormal_peptide_metabolism0.60453386
95MP0002136_abnormal_kidney_physiology0.60381730
96MP0005266_abnormal_metabolism0.59160618
97MP0003091_abnormal_cell_migration0.58821254
98MP0008873_increased_physiological_sensi0.58350328
99MP0002837_dystrophic_cardiac_calcinosis0.56814535
100MP0001663_abnormal_digestive_system0.56215467
101MP0000371_diluted_coat_color0.55863880
102MP0000703_abnormal_thymus_morphology0.55128005
103MP0010307_abnormal_tumor_latency0.54738437
104MP0009765_abnormal_xenobiotic_induced0.53490777
105MP0003763_abnormal_thymus_physiology0.52872215
106MP0002693_abnormal_pancreas_physiology0.52844613
107MP0005023_abnormal_wound_healing0.51305974
108MP0004808_abnormal_hematopoietic_stem0.48832985
109MP0008260_abnormal_autophagy0.48494164
110MP0005076_abnormal_cell_differentiation0.47439919
111MP0002090_abnormal_vision0.46941062
112MP0004147_increased_porphyrin_level0.44892991
113MP0005584_abnormal_enzyme/coenzyme_acti0.44870766
114MP0003866_abnormal_defecation0.44738000
115MP0005319_abnormal_enzyme/_coenzyme0.43166495
116MP0000465_gastrointestinal_hemorrhage0.42777042
117MP0000609_abnormal_liver_physiology0.42695484
118MP0005451_abnormal_body_composition0.41875309

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)7.41700963
2Recurrent abscess formation (HP:0002722)7.35399079
3Recurrent bacterial skin infections (HP:0005406)6.91993851
4Recurrent gram-negative bacterial infections (HP:0005420)6.64330080
5Elevated erythrocyte sedimentation rate (HP:0003565)5.73567161
6Mediastinal lymphadenopathy (HP:0100721)5.72953113
7Stomatitis (HP:0010280)5.72783111
8Systemic lupus erythematosus (HP:0002725)5.55675401
9Abnormality of macrophages (HP:0004311)5.34490425
10Orchitis (HP:0100796)4.51459645
11Autoimmune thrombocytopenia (HP:0001973)4.48186155
12Myositis (HP:0100614)4.35206597
13Optic neuritis (HP:0100653)4.22952163
14Retrobulbar optic neuritis (HP:0100654)4.22952163
15T lymphocytopenia (HP:0005403)4.22141753
16Increased neuronal autofluorescent lipopigment (HP:0002074)4.20321037
17Axonal loss (HP:0003447)4.12320898
18Vacuolated lymphocytes (HP:0001922)4.11445596
19Increased cerebral lipofuscin (HP:0011813)4.10973125
20Recurrent skin infections (HP:0001581)4.08925068
21Gingivitis (HP:0000230)4.06875967
22Obstructive lung disease (HP:0006536)3.98679755
23Chronic obstructive pulmonary disease (HP:0006510)3.98679755
24Loss of speech (HP:0002371)3.78801983
25Nausea (HP:0002018)3.77452955
26Interstitial pulmonary disease (HP:0006530)3.69115259
27Vasculitis (HP:0002633)3.66324111
28Autoimmune hemolytic anemia (HP:0001890)3.64704508
29Basal ganglia calcification (HP:0002135)3.62517360
30Recurrent fungal infections (HP:0002841)3.60894102
31Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.60727472
32Nuclear cataract (HP:0100018)3.56271946
33Disinhibition (HP:0000734)3.53073578
34Mutism (HP:0002300)3.43765256
35Glomerulonephritis (HP:0000099)3.38029145
36Gangrene (HP:0100758)3.26577632
37Agnosia (HP:0010524)3.22224965
38Poor head control (HP:0002421)3.21844178
39Recurrent viral infections (HP:0004429)3.16344372
40Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.11166504
41Urticaria (HP:0001025)3.10160101
42Tetraparesis (HP:0002273)3.07807259
43Petechiae (HP:0000967)3.04528627
44Pulmonary infiltrates (HP:0002113)3.02880724
45Neurofibrillary tangles (HP:0002185)3.02098768
46Abnormality of polysaccharide metabolism (HP:0011012)2.97281530
47Abnormality of glycosaminoglycan metabolism (HP:0004371)2.97281530
48Abnormality of mucopolysaccharide metabolism (HP:0011020)2.97281530
49Increased IgM level (HP:0003496)2.94270060
50Cellulitis (HP:0100658)2.86606739
51Abnormality of glycolipid metabolism (HP:0010969)2.74275716
52Abnormality of liposaccharide metabolism (HP:0010968)2.74275716
53Abnormality of glycosphingolipid metabolism (HP:0004343)2.74275716
54Hepatosplenomegaly (HP:0001433)2.67557303
55Thick nail (HP:0001805)2.65974853
56Purpura (HP:0000979)2.65135575
57Urinary glycosaminoglycan excretion (HP:0003541)2.64812804
58Mucopolysacchariduria (HP:0008155)2.64812804
59Polyneuropathy (HP:0001271)2.64161023
60Periodontitis (HP:0000704)2.61935039
61Nephritis (HP:0000123)2.59847109
62Meningitis (HP:0001287)2.59179202
63IgA deficiency (HP:0002720)2.58865506
64Pustule (HP:0200039)2.56525400
65Recurrent pneumonia (HP:0006532)2.54513862
66Encephalitis (HP:0002383)2.54425439
67Chronic mucocutaneous candidiasis (HP:0002728)2.52715769
68Recurrent cutaneous fungal infections (HP:0011370)2.52715769
69Abnormality of T cells (HP:0002843)2.46231268
70Apathy (HP:0000741)2.43732527
71Prostate neoplasm (HP:0100787)2.41783980
72Progressive neurologic deterioration (HP:0002344)2.40715961
73Keratoconjunctivitis sicca (HP:0001097)2.39778032
74Leukocytosis (HP:0001974)2.38812557
75Abnormality of the pericardium (HP:0001697)2.38331310
76Abnormality of the pleura (HP:0002103)2.37162885
77Diminished motivation (HP:0000745)2.36816712
78Dysostosis multiplex (HP:0000943)2.33456808
79Upper motor neuron abnormality (HP:0002127)2.32291923
80Arterial thrombosis (HP:0004420)2.30787570
81Joint swelling (HP:0001386)2.29364594
82Recurrent lower respiratory tract infections (HP:0002783)2.25674957
83Progressive visual loss (HP:0000529)2.24807768
84Osteomyelitis (HP:0002754)2.24428726
85Chronic diarrhea (HP:0002028)2.24321514
86Combined immunodeficiency (HP:0005387)2.22444186
87Hemoptysis (HP:0002105)2.20870527
88Zonular cataract (HP:0010920)2.20658005
89Gingival bleeding (HP:0000225)2.20055843
90Keratoconjunctivitis (HP:0001096)2.18489937
91Bone pain (HP:0002653)2.15444883
92Hypergammaglobulinemia (HP:0010702)2.15442057
93Porencephaly (HP:0002132)2.14747727
94Abnormal delayed hypersensitivity skin test (HP:0002963)2.14480014
95IgG deficiency (HP:0004315)2.14143372
96Premature loss of primary teeth (HP:0006323)2.12554085
97Joint hemorrhage (HP:0005261)2.10595569
98Episodic fever (HP:0001954)2.09837355
99Hemorrhage of the eye (HP:0011885)2.09256376
100Arthralgia (HP:0002829)2.08820231
101Pulmonary embolism (HP:0002204)2.07363936
102Fused cervical vertebrae (HP:0002949)2.06366171
103Abnormality of B cell number (HP:0010975)2.05880763
104Parakeratosis (HP:0001036)2.05007491
105Metaphyseal irregularity (HP:0003025)2.04179052
106Complement deficiency (HP:0004431)2.03699971
107Pathologic fracture (HP:0002756)2.03033619
108Increased serum ferritin (HP:0003281)2.02961803
109Anorexia (HP:0002039)2.02257567
110Personality changes (HP:0000751)2.01583952
111Cerebral inclusion bodies (HP:0100314)2.00942216
112Abnormality of eosinophils (HP:0001879)1.99490371
113Recurrent bronchitis (HP:0002837)1.98299961
114Amaurosis fugax (HP:0100576)1.97648045
115Glomerulopathy (HP:0100820)1.97410752
116Esophageal neoplasm (HP:0100751)1.96377339
117Neoplasm of head and neck (HP:0012288)1.96377339
118Vertigo (HP:0002321)1.94244504
119Myocardial infarction (HP:0001658)1.93508388
120Gastrointestinal stroma tumor (HP:0100723)1.91566344
121Spontaneous hematomas (HP:0007420)1.91406184
122Prolonged neonatal jaundice (HP:0006579)1.90873990
123Gastrointestinal infarctions (HP:0005244)1.90272716
124Abnormality of T cell number (HP:0011839)1.86313659
125Chronic otitis media (HP:0000389)1.85542167
126Inappropriate behavior (HP:0000719)1.81894122
127Sepsis (HP:0100806)1.80515654
128Abnormality of iron homeostasis (HP:0011031)1.78099080
129Abnormality of complement system (HP:0005339)1.75855743
130Hematochezia (HP:0002573)1.75752092
131Peritonitis (HP:0002586)1.75551773
132Eosinophilia (HP:0001880)1.75077803
133Memory impairment (HP:0002354)1.74991164
134Vertebral compression fractures (HP:0002953)1.74986864
135Amyloidosis (HP:0011034)1.73475511
136Lower limb hyperreflexia (HP:0002395)1.72350542

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.78006491
2RIPK44.40288707
3PBK4.17772202
4MAP3K143.94974998
5TBK13.81610811
6TXK3.75557050
7ERN13.27003665
8IRAK32.98692343
9IRAK42.92640532
10MAP4K12.76412560
11DDR22.67597945
12IKBKB2.56541473
13IKBKE2.46228953
14TYK22.35686211
15JAK31.98916134
16NME21.93415691
17PIM21.88122781
18CSK1.72601832
19KIT1.70167419
20BMPR21.56287703
21FGR1.54291684
22BMX1.54162415
23GRK71.47515938
24ABL21.45591341
25ZAP701.45011286
26MUSK1.44372169
27MAP3K131.39958402
28CHUK1.39534914
29LYN1.39412814
30SYK1.33976705
31SIK31.30360468
32KDR1.29082030
33JAK11.27870414
34TYRO31.25918545
35MST1R1.25646425
36PRPF4B1.20981372
37HCK1.20200618
38TGFBR21.17339682
39TESK21.16002833
40ACVR1B1.15893995
41BTK1.14163847
42MATK1.11645538
43CSF1R1.11521903
44LCK1.11384374
45ADRBK21.10642800
46CDC42BPA1.04772085
47EIF2AK21.04466253
48MARK31.03717819
49RPS6KA41.00889179
50SIK20.94722925
51MAP3K30.93989833
52STK100.91467664
53MAP3K50.91343956
54FES0.89343885
55PIM10.88845768
56MAP2K30.86955776
57JAK20.84086121
58MAP2K60.83047892
59MAP3K120.77578892
60TEC0.77191372
61YES10.76622430
62PRKCD0.72120582
63IRAK20.69637287
64ERBB40.67423674
65MAP3K110.61515904
66NEK90.59884510
67ABL10.59529725
68ITK0.59170289
69STK40.56158927
70EGFR0.55596416
71MOS0.54754521
72MST40.53303084
73TAOK30.52225621
74DAPK30.51684511
75EPHB10.47897602
76CLK10.47126493
77ARAF0.45184840
78IRAK10.43930752
79SIK10.42397479
80CAMKK20.42231562
81DAPK20.39572405
82FYN0.38498641
83PDGFRA0.36752526
84BCKDK0.36187467
85LRRK20.35552319
86PRKG20.35354705
87PKN10.34825401
88IGF1R0.34789016
89LATS20.34392890
90ADRBK10.33223044
91DYRK30.29796557
92TRPM70.29762177
93TAOK20.28882855
94INSR0.28440548
95MAP3K10.28366913
96PRKCQ0.26297651
97MAPK40.25577659
98HIPK20.25540695
99MAPKAPK20.22931184
100ERBB30.22901666
101TNK20.22753296
102PIK3CA0.22663719
103RIPK10.21241864
104RPS6KA60.19383940
105CDK60.19286581
106STK30.18183172
107EPHA30.18165659
108PDK10.18057858
109RPS6KA10.17845004
110BMPR1B0.17340506
111PDPK10.17059724
112EIF2AK10.16911154
113KSR20.15975839
114EIF2AK30.14355611
115PIK3CG0.13928899
116GSK3A0.13818785
117MAPK30.13182766
118CDK140.12548780
119DYRK1B0.12317397
120PAK10.11433793
121SRC0.11404218
122TESK10.11222740
123CDK150.10127292
124RPS6KL10.09684207
125RPS6KC10.09684207
126TAOK10.08560423
127PDGFRB0.07686976

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053325.06620689
2Type I diabetes mellitus_Homo sapiens_hsa049403.52475704
3Allograft rejection_Homo sapiens_hsa053303.50027855
4Leishmaniasis_Homo sapiens_hsa051403.45888766
5Asthma_Homo sapiens_hsa053103.28091597
6Legionellosis_Homo sapiens_hsa051342.97026250
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.88650633
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.84583076
9Staphylococcus aureus infection_Homo sapiens_hsa051502.77794179
10* Toll-like receptor signaling pathway_Homo sapiens_hsa046202.67886479
11* Rheumatoid arthritis_Homo sapiens_hsa053232.64442269
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.55083379
13Malaria_Homo sapiens_hsa051442.53791149
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.50671939
15Pertussis_Homo sapiens_hsa051332.49067777
16African trypanosomiasis_Homo sapiens_hsa051432.26453254
17Tuberculosis_Homo sapiens_hsa051522.21063789
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.16781313
19Osteoclast differentiation_Homo sapiens_hsa043802.14211615
20TNF signaling pathway_Homo sapiens_hsa046682.05100419
21* Salmonella infection_Homo sapiens_hsa051321.97091747
22Hematopoietic cell lineage_Homo sapiens_hsa046401.85691446
23Measles_Homo sapiens_hsa051621.81315270
24Influenza A_Homo sapiens_hsa051641.66466995
25* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.64172249
26* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.51485347
27Phagosome_Homo sapiens_hsa041451.40093802
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.34156262
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.33351992
30Herpes simplex infection_Homo sapiens_hsa051681.32083481
31Lysosome_Homo sapiens_hsa041421.27792169
32Toxoplasmosis_Homo sapiens_hsa051451.21164252
33* Chemokine signaling pathway_Homo sapiens_hsa040621.19427095
34Autoimmune thyroid disease_Homo sapiens_hsa053201.18590193
35Prion diseases_Homo sapiens_hsa050201.14836038
36Antigen processing and presentation_Homo sapiens_hsa046121.12899848
37Amoebiasis_Homo sapiens_hsa051461.12557968
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.07492523
39B cell receptor signaling pathway_Homo sapiens_hsa046621.02971061
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98226646
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97450263
42Shigellosis_Homo sapiens_hsa051310.96536769
43Apoptosis_Homo sapiens_hsa042100.90196984
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88253926
45Other glycan degradation_Homo sapiens_hsa005110.84125247
46Hepatitis B_Homo sapiens_hsa051610.82418883
47Hepatitis C_Homo sapiens_hsa051600.80837476
48T cell receptor signaling pathway_Homo sapiens_hsa046600.79978464
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78047886
50Bladder cancer_Homo sapiens_hsa052190.76883245
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74160156
52Collecting duct acid secretion_Homo sapiens_hsa049660.73647963
53Complement and coagulation cascades_Homo sapiens_hsa046100.63028292
54Sulfur metabolism_Homo sapiens_hsa009200.59940230
55Adipocytokine signaling pathway_Homo sapiens_hsa049200.57254740
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57080920
57Mineral absorption_Homo sapiens_hsa049780.55255022
58Viral myocarditis_Homo sapiens_hsa054160.53643368
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53593855
60Glycosaminoglycan degradation_Homo sapiens_hsa005310.53328008
61Type II diabetes mellitus_Homo sapiens_hsa049300.53281587
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50317926
63Primary immunodeficiency_Homo sapiens_hsa053400.50286670
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50082844
65Leukocyte transendothelial migration_Homo sapiens_hsa046700.45311554
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.38389898
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35788214
68Epstein-Barr virus infection_Homo sapiens_hsa051690.35733494
69Platelet activation_Homo sapiens_hsa046110.33076815
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32809472
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32730084
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.32198460
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31689800
74Acute myeloid leukemia_Homo sapiens_hsa052210.30574955
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28337589
76HIF-1 signaling pathway_Homo sapiens_hsa040660.26529769
77Systemic lupus erythematosus_Homo sapiens_hsa053220.22096381
78Proteasome_Homo sapiens_hsa030500.20768375
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.20750874
80Prolactin signaling pathway_Homo sapiens_hsa049170.20518566
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19303726
82Galactose metabolism_Homo sapiens_hsa000520.19034428
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.18300159
84VEGF signaling pathway_Homo sapiens_hsa043700.16469985
85Vibrio cholerae infection_Homo sapiens_hsa051100.16027507
86Tryptophan metabolism_Homo sapiens_hsa003800.15702267
87Chronic myeloid leukemia_Homo sapiens_hsa052200.15021485
88Insulin resistance_Homo sapiens_hsa049310.14667470
89Pancreatic cancer_Homo sapiens_hsa052120.14562115
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.13571259
91HTLV-I infection_Homo sapiens_hsa051660.11468541
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.10652018
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.09252239
94MAPK signaling pathway_Homo sapiens_hsa040100.08888385
95Viral carcinogenesis_Homo sapiens_hsa052030.08684705
96Caffeine metabolism_Homo sapiens_hsa002320.07257692
97Proteoglycans in cancer_Homo sapiens_hsa052050.06457408
98PPAR signaling pathway_Homo sapiens_hsa033200.04918964
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.04781181
100Small cell lung cancer_Homo sapiens_hsa052220.03831575
101Regulation of autophagy_Homo sapiens_hsa041400.03281385
102Endocytosis_Homo sapiens_hsa041440.01912312
103Sphingolipid metabolism_Homo sapiens_hsa006000.01442764
104mTOR signaling pathway_Homo sapiens_hsa041500.01142372
105Renin-angiotensin system_Homo sapiens_hsa046140.01031025
106Dorso-ventral axis formation_Homo sapiens_hsa043200.00967577
107Steroid biosynthesis_Homo sapiens_hsa001000.00786539
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.00579646
109Arachidonic acid metabolism_Homo sapiens_hsa005900.00545307
110Primary bile acid biosynthesis_Homo sapiens_hsa00120-0.0334740
111Fatty acid biosynthesis_Homo sapiens_hsa00061-0.0229992
112Notch signaling pathway_Homo sapiens_hsa04330-0.0220899
113FoxO signaling pathway_Homo sapiens_hsa04068-0.0099199
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514-0.0031045

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