CCL3L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility. This record represents one of two copies that are present on the ALT_REF_LOCI_2 alternate haplotype of the GRCh38 human reference genome assembly. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vitamin D biosynthetic process (GO:0060556)6.85886662
2regulation of chronic inflammatory response (GO:0002676)6.78178490
3positive regulation of heat generation (GO:0031652)6.14598191
4regulation of fever generation (GO:0031620)6.11506061
5regulation of vitamin metabolic process (GO:0030656)5.45582192
6regulation of mononuclear cell migration (GO:0071675)5.34391817
7positive regulation of chemokine biosynthetic process (GO:0045080)5.30261513
8regulation of cytokine secretion involved in immune response (GO:0002739)5.29512888
9lipopolysaccharide-mediated signaling pathway (GO:0031663)4.86379360
10regulation of chemokine biosynthetic process (GO:0045073)4.84495483
11regulation of T-helper 1 cell differentiation (GO:0045625)4.83974490
12regulation of heat generation (GO:0031650)4.75856972
13negative regulation of interleukin-12 production (GO:0032695)4.63217360
14regulation of podosome assembly (GO:0071801)4.63055234
15positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.55503892
16monocyte chemotaxis (GO:0002548)4.51043886
17eosinophil chemotaxis (GO:0048245)4.49164247
18negative regulation of cytokine production involved in immune response (GO:0002719)4.31531625
19cellular response to type I interferon (GO:0071357)4.02315116
20type I interferon signaling pathway (GO:0060337)4.02315116
21regulation of interferon-alpha production (GO:0032647)4.02200616
22negative regulation of viral genome replication (GO:0045071)3.99654476
23eosinophil migration (GO:0072677)3.99055322
24response to type I interferon (GO:0034340)3.95599678
25regulation of immunoglobulin secretion (GO:0051023)3.95041119
26regulation of lymphocyte chemotaxis (GO:1901623)3.91342301
27cellular response to nicotine (GO:0071316)3.89873199
28response to peptidoglycan (GO:0032494)3.89649229
29branching involved in labyrinthine layer morphogenesis (GO:0060670)3.88395058
30positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.86005100
31positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.84872540
32positive regulation of NF-kappaB import into nucleus (GO:0042346)3.83766830
33regulation of membrane protein ectodomain proteolysis (GO:0051043)3.81594170
34positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.78115619
35activation of MAPKKK activity (GO:0000185)3.73596786
36negative regulation of nitric oxide biosynthetic process (GO:0045019)3.72617255
37regulation of nitric oxide biosynthetic process (GO:0045428)3.63961900
38positive regulation of acute inflammatory response (GO:0002675)3.63172559
39negative regulation of amino acid transport (GO:0051956)3.62500525
40positive regulation of nitric oxide biosynthetic process (GO:0045429)3.62468342
41myeloid dendritic cell differentiation (GO:0043011)3.55192686
42negative regulation of production of molecular mediator of immune response (GO:0002701)3.53901867
43T cell migration (GO:0072678)3.53432371
44positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.46881336
45regulation of interleukin-12 biosynthetic process (GO:0045075)3.44899790
46positive regulation of gamma-delta T cell activation (GO:0046645)3.37657479
47regulation of interleukin-8 biosynthetic process (GO:0045414)3.35756702
48response to protozoan (GO:0001562)3.34323889
49modulation of growth of symbiont involved in interaction with host (GO:0044144)3.34158226
50regulation of growth of symbiont in host (GO:0044126)3.34158226
51negative regulation of growth of symbiont in host (GO:0044130)3.34158226
52negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.34158226
53granulocyte activation (GO:0036230)3.33986835
54lymphocyte chemotaxis (GO:0048247)3.33632920
55positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.28990415
56cellular response to lipopolysaccharide (GO:0071222)3.26771398
57regulation of heterotypic cell-cell adhesion (GO:0034114)3.26400720
58macrophage chemotaxis (GO:0048246)3.21541979
59interferon-gamma-mediated signaling pathway (GO:0060333)3.18722633
60defense response to protozoan (GO:0042832)3.18472568
61immunoglobulin mediated immune response (GO:0016064)3.16198441
62regulation of interleukin-12 production (GO:0032655)3.15688733
63positive regulation of lymphocyte migration (GO:2000403)3.15266229
64positive regulation of interferon-alpha production (GO:0032727)3.13457935
65cellular response to molecule of bacterial origin (GO:0071219)3.13268643
66regulation of NF-kappaB import into nucleus (GO:0042345)3.12798138
67negative regulation of lipid storage (GO:0010888)3.09490060
68myeloid dendritic cell activation (GO:0001773)3.09240776
69macrophage activation involved in immune response (GO:0002281)3.08857284
70positive regulation of defense response to virus by host (GO:0002230)3.08822868
71regulation of interleukin-2 biosynthetic process (GO:0045076)3.08251667
72negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.06561593
73positive regulation of lymphocyte apoptotic process (GO:0070230)3.06245148
74positive regulation of humoral immune response (GO:0002922)3.05169016
75positive regulation of type 2 immune response (GO:0002830)3.03633720
76regulation of inflammatory response to antigenic stimulus (GO:0002861)3.02879138
77regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.01698259
78regulation of T-helper cell differentiation (GO:0045622)3.00977285
79T-helper 1 type immune response (GO:0042088)2.99764865
80positive regulation of interleukin-6 production (GO:0032755)2.98648264
81sarcoplasmic reticulum calcium ion transport (GO:0070296)2.98565818
82NIK/NF-kappaB signaling (GO:0038061)2.95167957
83positive regulation of interleukin-1 beta secretion (GO:0050718)2.94043327
84regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.93581602
85regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.91412519
86positive regulation of hair follicle development (GO:0051798)2.89510414
87positive regulation of hair cycle (GO:0042635)2.89510414
88regulation of lymphocyte migration (GO:2000401)2.88975933
89negative regulation of viral process (GO:0048525)2.87944812
90germinal center formation (GO:0002467)2.87539636
91regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.86019758
92positive regulation of B cell mediated immunity (GO:0002714)2.82502823
93positive regulation of immunoglobulin mediated immune response (GO:0002891)2.82502823
94cellular response to interferon-gamma (GO:0071346)2.82237170
95positive regulation of interleukin-12 production (GO:0032735)2.82179513
96negative regulation by host of viral transcription (GO:0043922)2.81441609
97regulation of type 2 immune response (GO:0002828)2.81193189
98regulation of interleukin-1 beta secretion (GO:0050706)2.80926415
99positive regulation of transcription factor import into nucleus (GO:0042993)2.80856050
100regulation of viral genome replication (GO:0045069)2.80504688

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.85235894
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.02375326
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.47883053
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.84988726
5RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human4.34650681
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.74832785
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.70317132
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.53416384
9* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.38041239
10STAT4_19710469_ChIP-ChIP_TH1__Mouse3.34350466
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.20724609
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.16148296
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.88985917
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.85590219
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.79810855
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.59998212
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.55293962
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.37569568
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.33179105
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.20966295
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.11767399
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.85694581
23VDR_24787735_ChIP-Seq_THP-1_Human1.83542392
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.79035638
25BRD4_27068464_Chip-Seq_AML-cells_Mouse1.75943282
26RUNX_20019798_ChIP-Seq_JUKART_Human1.75839893
27PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.69288165
28MYB_26560356_Chip-Seq_TH2_Human1.66922984
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.66579548
30SPI1_23547873_ChIP-Seq_NB4_Human1.57191354
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.52249067
32MAF_26560356_Chip-Seq_TH1_Human1.48110390
33SPI1_23127762_ChIP-Seq_K562_Human1.47738020
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46850589
35VDR_24763502_ChIP-Seq_THP-1_Human1.44921376
36NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.43915304
37LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.41200135
38GATA1_22025678_ChIP-Seq_K562_Human1.40410701
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39784376
40CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39313431
41STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36210054
42SCL_19346495_ChIP-Seq_HPC-7_Human1.35679039
43FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.34834793
44GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.34507418
45TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32212765
46TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.29859168
47PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24091064
48GATA3_27048872_Chip-Seq_THYMUS_Human1.23033633
49CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.22979078
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22564850
51PU_27001747_Chip-Seq_BMDM_Mouse1.20432689
52VDR_21846776_ChIP-Seq_THP-1_Human1.19330661
53CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18840352
54MYB_26560356_Chip-Seq_TH1_Human1.18661570
55CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16622159
56GATA3_26560356_Chip-Seq_TH2_Human1.13865869
57SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12461406
58UTX_26944678_Chip-Seq_JUKART_Human1.11755962
59PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10212661
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.08989775
61KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08705208
62KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08705208
63KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08705208
64MAF_26560356_Chip-Seq_TH2_Human1.08660083
65CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06495539
66RUNX1_22412390_ChIP-Seq_EML_Mouse1.06233411
67STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04918617
68STAT1_20625510_ChIP-Seq_HELA_Human1.01970921
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.01489899
70JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00671742
71SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99999905
72TP63_17297297_ChIP-ChIP_HaCaT_Human0.99407976
73ESR2_21235772_ChIP-Seq_MCF-7_Human0.99198028
74KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97030618
75ELK3_25401928_ChIP-Seq_HUVEC_Human0.96467797
76FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.96117814
77VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95980061
78VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95144528
79JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94798205
80PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92893867
81SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.91600292
82TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89069824
83GATA1_19941826_ChIP-Seq_K562_Human0.88043499
84TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86385741
85GATA1_19941827_ChIP-Seq_MEL_Mouse0.84689850
86GATA2_22383799_ChIP-Seq_G1ME_Mouse0.84475883
87TFEB_21752829_ChIP-Seq_HELA_Human0.83710017
88EGR1_19032775_ChIP-ChIP_M12_Human0.81547514
89ESR1_21235772_ChIP-Seq_MCF-7_Human0.79722151
90PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.79681949
91LXR_22292898_ChIP-Seq_THP-1_Human0.78358486
92KDM2B_26808549_Chip-Seq_DND41_Human0.75925655
93STAT3_1855785_ChIP-Seq_MESCs_Mouse0.74403892
94CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.72913643
95ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.69645257
96THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.68911958
97PU.1_20513432_ChIP-Seq_Bcells_Mouse0.68897969
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68795530
99BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.68041677
100GATA1_19941827_ChIP-Seq_MEL86_Mouse0.67699964

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation6.07472510
2MP0006082_CNS_inflammation4.46330169
3MP0009785_altered_susceptibility_to3.91748068
4MP0002148_abnormal_hypersensitivity_rea3.69323341
5MP0005671_abnormal_response_to3.63852543
6MP0003436_decreased_susceptibility_to3.54205877
7MP0003724_increased_susceptibility_to3.01312927
8MP0005000_abnormal_immune_tolerance2.96334667
9MP0004510_myositis2.92017940
10MP0001835_abnormal_antigen_presentation2.88750338
11MP0009764_decreased_sensitivity_to2.73896345
12MP0001790_abnormal_immune_system2.61278838
13MP0005387_immune_system_phenotype2.61278838
14MP0005025_abnormal_response_to2.52922848
15MP0005058_abnormal_lysosome_morphology2.52455277
16MP0002139_abnormal_hepatobiliary_system2.39322397
17MP0002419_abnormal_innate_immunity2.38446652
18MP0008004_abnormal_stomach_pH2.37077879
19MP0003300_gastrointestinal_ulcer2.29852952
20MP0002723_abnormal_immune_serum2.23900480
21MP0003075_altered_response_to2.22263181
22MP0001800_abnormal_humoral_immune2.21193347
23MP0004947_skin_inflammation2.16200436
24MP0002452_abnormal_antigen_presenting2.14167045
25MP0009840_abnormal_foam_cell2.08166224
26MP0010155_abnormal_intestine_physiology2.06184344
27MP0005167_abnormal_blood-brain_barrier2.04108178
28MP0001533_abnormal_skeleton_physiology2.01275470
29MP0002332_abnormal_exercise_endurance1.99247305
30MP0000343_altered_response_to1.98601358
31MP0003448_altered_tumor_morphology1.87722901
32MP0001853_heart_inflammation1.87304189
33MP0009333_abnormal_splenocyte_physiolog1.86787590
34MP0001845_abnormal_inflammatory_respons1.84296271
35MP0002420_abnormal_adaptive_immunity1.80967450
36MP0001819_abnormal_immune_cell1.80428473
37MP0005451_abnormal_body_composition1.79029169
38MP0003195_calcinosis1.72740715
39MP0008469_abnormal_protein_level1.66861512
40MP0002405_respiratory_system_inflammati1.58324227
41MP0003453_abnormal_keratinocyte_physiol1.53193016
42MP0006054_spinal_hemorrhage1.52799894
43MP0003172_abnormal_lysosome_physiology1.43670087
44MP0005166_decreased_susceptibility_to1.42745198
45MP0005310_abnormal_salivary_gland1.40145386
46MP0002998_abnormal_bone_remodeling1.39961495
47MP0003690_abnormal_glial_cell1.38600204
48MP0009278_abnormal_bone_marrow1.38438498
49MP0000604_amyloidosis1.37650978
50MP0000716_abnormal_immune_system1.32791343
51MP0001501_abnormal_sleep_pattern1.31568696
52MP0000685_abnormal_immune_system1.30420430
53MP0003806_abnormal_nucleotide_metabolis1.28536322
54MP0002254_reproductive_system_inflammat1.28346616
55MP0000858_altered_metastatic_potential1.18801696
56MP0005464_abnormal_platelet_physiology1.14562123
57MP0002398_abnormal_bone_marrow1.13989065
58MP0009763_increased_sensitivity_to1.13603427
59MP0005397_hematopoietic_system_phenotyp1.12844822
60MP0001545_abnormal_hematopoietic_system1.12844822
61MP0003763_abnormal_thymus_physiology1.11067372
62MP0003646_muscle_fatigue1.09352575
63MP0009765_abnormal_xenobiotic_induced1.08850286
64MP0003656_abnormal_erythrocyte_physiolo1.03158317
65MP0005165_increased_susceptibility_to1.00286652
66MP0001542_abnormal_bone_strength0.98911588
67MP0002429_abnormal_blood_cell0.98768851
68MP0005164_abnormal_response_to0.98022411
69MP0000920_abnormal_myelination0.94887478
70MP0000689_abnormal_spleen_morphology0.93325445
71MP0002138_abnormal_hepatobiliary_system0.90854641
72MP0005647_abnormal_sex_gland0.89954826
73MP0002722_abnormal_immune_system0.89700040
74MP0005390_skeleton_phenotype0.89237541
75MP0010307_abnormal_tumor_latency0.81020466
76MP0001663_abnormal_digestive_system0.77211200
77MP0002933_joint_inflammation0.74239593
78MP0008874_decreased_physiological_sensi0.73410178
79MP0004808_abnormal_hematopoietic_stem0.68766275
80MP0005666_abnormal_adipose_tissue0.68418156
81MP0001727_abnormal_embryo_implantation0.68152993
82MP0001873_stomach_inflammation0.67715395
83MP0003091_abnormal_cell_migration0.66518108
84MP0005023_abnormal_wound_healing0.65956106
85MP0005535_abnormal_body_temperature0.65817617
86MP0002877_abnormal_melanocyte_morpholog0.63815050
87MP0005266_abnormal_metabolism0.62105971
88MP0010352_gastrointestinal_tract_polyps0.59854368
89MP0003045_fibrosis0.59648595
90MP0000249_abnormal_blood_vessel0.58294410
91MP0003795_abnormal_bone_structure0.55800933
92MP0003866_abnormal_defecation0.52137162
93MP0002693_abnormal_pancreas_physiology0.51904194
94MP0008873_increased_physiological_sensi0.50729257
95MP0003191_abnormal_cellular_cholesterol0.49409760
96MP0003183_abnormal_peptide_metabolism0.47914012
97MP0000609_abnormal_liver_physiology0.47836841
98MP0005319_abnormal_enzyme/_coenzyme0.47692467
99MP0002277_abnormal_respiratory_mucosa0.47668276
100MP0001764_abnormal_homeostasis0.47640874

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)6.70244765
2Abnormality of glycosphingolipid metabolism (HP:0004343)6.70244765
3Abnormality of glycolipid metabolism (HP:0010969)6.70244765
4Optic neuritis (HP:0100653)5.90437369
5Retrobulbar optic neuritis (HP:0100654)5.90437369
6Orchitis (HP:0100796)5.53546503
7Abnormality of macrophages (HP:0004311)4.98479243
8Myositis (HP:0100614)4.79234198
9Vacuolated lymphocytes (HP:0001922)4.70400770
10Stomatitis (HP:0010280)4.41101816
11Recurrent bacterial skin infections (HP:0005406)4.32200726
12Systemic lupus erythematosus (HP:0002725)4.16667895
13Autoimmune thrombocytopenia (HP:0001973)4.07503309
14Keratoconjunctivitis sicca (HP:0001097)4.06270578
15Dysostosis multiplex (HP:0000943)4.03050291
16Increased cerebral lipofuscin (HP:0011813)3.85255006
17Loss of speech (HP:0002371)3.84052421
18Disinhibition (HP:0000734)3.80013679
19Nausea (HP:0002018)3.74895393
20Recurrent abscess formation (HP:0002722)3.73150576
21Keratoconjunctivitis (HP:0001096)3.71769671
22Mediastinal lymphadenopathy (HP:0100721)3.70153004
23T lymphocytopenia (HP:0005403)3.66428212
24Mutism (HP:0002300)3.59363719
25Gangrene (HP:0100758)3.55915980
26Nuclear cataract (HP:0100018)3.54466776
27Autoimmune hemolytic anemia (HP:0001890)3.45353614
28Abnormality of T cell number (HP:0011839)3.44339755
29Neurofibrillary tangles (HP:0002185)3.36847002
30Pulmonary infiltrates (HP:0002113)3.28313386
31Vasculitis (HP:0002633)3.19846046
32Increased neuronal autofluorescent lipopigment (HP:0002074)3.17127712
33Hematochezia (HP:0002573)3.07091411
34Increased IgM level (HP:0003496)3.06611360
35Hemoptysis (HP:0002105)3.03691888
36Eczematoid dermatitis (HP:0000976)3.03200879
37Abnormality of polysaccharide metabolism (HP:0011012)2.99608617
38Abnormality of glycosaminoglycan metabolism (HP:0004371)2.99608617
39Abnormality of mucopolysaccharide metabolism (HP:0011020)2.99608617
40Parakeratosis (HP:0001036)2.95846936
41Increased serum ferritin (HP:0003281)2.89584605
42Recurrent viral infections (HP:0004429)2.75423837
43Mucopolysacchariduria (HP:0008155)2.73029019
44Urinary glycosaminoglycan excretion (HP:0003541)2.73029019
45Polyneuropathy (HP:0001271)2.71225024
46Apathy (HP:0000741)2.62961629
47Abnormality of the pleura (HP:0002103)2.61682574
48Joint swelling (HP:0001386)2.61002237
49Arterial thrombosis (HP:0004420)2.59750641
50Zonular cataract (HP:0010920)2.58575213
51Recurrent gram-negative bacterial infections (HP:0005420)2.58436485
52Encephalitis (HP:0002383)2.58283326
53Glomerulonephritis (HP:0000099)2.56669802
54Obstructive lung disease (HP:0006536)2.53230101
55Chronic obstructive pulmonary disease (HP:0006510)2.53230101
56Meningitis (HP:0001287)2.51732683
57Diminished motivation (HP:0000745)2.48826529
58Elevated erythrocyte sedimentation rate (HP:0003565)2.48712865
59Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.48584029
60Anorexia (HP:0002039)2.47629468
61Abnormality of the pericardium (HP:0001697)2.42804067
62Progressive neurologic deterioration (HP:0002344)2.34575357
63Interstitial pulmonary disease (HP:0006530)2.32307375
64Recurrent skin infections (HP:0001581)2.30509682
65Hepatosplenomegaly (HP:0001433)2.30496076
66Cerebral inclusion bodies (HP:0100314)2.28973774
67Basal ganglia calcification (HP:0002135)2.26326212
68Recurrent fungal infections (HP:0002841)2.23786033
69Vertigo (HP:0002321)2.22619042
70Agnosia (HP:0010524)2.21280604
71Leukocytosis (HP:0001974)2.19551470
72Abnormality of iron homeostasis (HP:0011031)2.18728668
73Pulmonary embolism (HP:0002204)2.14861061
74Abnormality of B cell number (HP:0010975)2.14730339
75Axonal loss (HP:0003447)2.13344560
76Hypergammaglobulinemia (HP:0010702)2.12529043
77Neuronal loss in central nervous system (HP:0002529)2.12322888
78IgA deficiency (HP:0002720)2.11954310
79Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.11776723
80Glomerulopathy (HP:0100820)2.11751987
81Memory impairment (HP:0002354)2.11492215
82Gastrointestinal infarctions (HP:0005244)2.11224560
83Abnormality of the vasculature of the conjunctiva (HP:0008054)2.10000945
84Acne (HP:0001061)2.09783291
85Metaphyseal irregularity (HP:0003025)2.04790200
86Thoracolumbar scoliosis (HP:0002944)2.03891919
87Amyloidosis (HP:0011034)2.03440226
88B lymphocytopenia (HP:0010976)2.02565528
89Purpura (HP:0000979)2.00886523
90Abnormality of T cells (HP:0002843)2.00480657
91Inappropriate behavior (HP:0000719)1.99454962
92Prolonged neonatal jaundice (HP:0006579)1.98508963
93Complement deficiency (HP:0004431)1.97729865
94Personality changes (HP:0000751)1.96718029
95Keratitis (HP:0000491)1.96366222
96Myocardial infarction (HP:0001658)1.94979893
97Arthralgia (HP:0002829)1.93723242
98Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.92134741
99Recurrent bronchitis (HP:0002837)1.91436102
100Abnormality of the endocardium (HP:0004306)1.90079109

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK36.57708735
2GRK74.35717527
3TXK3.93501912
4TAOK23.21171293
5MAP3K143.04668987
6NME22.99892125
7DDR22.83759151
8TBK12.82384906
9MATK2.50719630
10RIPK12.48410633
11IRAK42.46467105
12MAP4K12.40757310
13IKBKE2.30235137
14IKBKB2.21483866
15ADRBK22.20744305
16BMPR22.17591415
17BLK2.09277030
18PIM22.01184310
19MOS1.94659686
20TAOK11.93365420
21MAP3K111.87418754
22RIPK41.87255929
23CSK1.72534990
24MAP3K31.68979317
25PRPF4B1.68836400
26FGR1.61421464
27TYK21.59356772
28JAK31.51054282
29TGFBR21.50053667
30IRAK21.43553266
31CHUK1.38767242
32TYRO31.31036931
33IRAK11.30304527
34CDC42BPA1.21260984
35ACVR1B1.14087873
36ZAP701.11241652
37MAP3K51.10651964
38LYN1.06492562
39SYK1.03278947
40JAK11.01902028
41ABL20.96661494
42MAP2K30.95471393
43ITK0.86049079
44MAP3K10.85696718
45CLK10.85424800
46LCK0.83815585
47STK100.83216845
48JAK20.82484685
49LATS20.81069040
50MAP2K60.80080130
51KDR0.73600904
52PIM10.71264824
53TAOK30.65270867
54CSF1R0.63869803
55PKN10.61001714
56MARK30.60473466
57ERN10.59902613
58TESK20.58470565
59MAP3K130.53675071
60EIF2AK20.45595720
61FES0.45445407
62PDGFRA0.43377807
63DAPK20.42718965
64MAPK40.42264447
65EIF2AK30.42127249
66BTK0.41621991
67HCK0.41452280
68DYRK30.39083214
69INSR0.36430322
70DAPK30.33811325
71PRKCQ0.33638120
72CDK60.32765144
73BCKDK0.31971984
74HIPK20.31862369
75PDGFRB0.30297608
76FYN0.30013022
77ARAF0.29509502
78BMX0.28830914
79PDK10.25753022
80GSK3A0.23961277
81ABL10.23885217
82CAMKK20.23242649
83MELK0.22284689
84KIT0.22236000
85EGFR0.20612894
86STK160.20403275
87SIK30.17880138
88TRIM280.17516141
89MAPKAPK20.16004454
90PAK40.15704262
91ZAK0.14996302
92EPHA30.14837269
93CDK140.14551357
94TESK10.14347831
95CDK150.13744530
96PRKCD0.13344107
97IGF1R0.12280153
98PIK3CA0.11049754
99CDK180.10382679
100MAPK30.08656928

Predicted pathways (KEGG)

RankGene SetZ-score
1* Toll-like receptor signaling pathway_Homo sapiens_hsa046203.26480389
2* Rheumatoid arthritis_Homo sapiens_hsa053233.24314074
3Allograft rejection_Homo sapiens_hsa053303.15117318
4NF-kappa B signaling pathway_Homo sapiens_hsa040643.10152694
5Graft-versus-host disease_Homo sapiens_hsa053323.04134453
6Malaria_Homo sapiens_hsa051442.69745388
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.69165836
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.67736183
9Asthma_Homo sapiens_hsa053102.63949475
10TNF signaling pathway_Homo sapiens_hsa046682.55565964
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.53866991
12Legionellosis_Homo sapiens_hsa051342.39928976
13Autoimmune thyroid disease_Homo sapiens_hsa053202.37688255
14Leishmaniasis_Homo sapiens_hsa051402.34004651
15African trypanosomiasis_Homo sapiens_hsa051432.32835654
16Osteoclast differentiation_Homo sapiens_hsa043802.29956696
17Type I diabetes mellitus_Homo sapiens_hsa049402.27793836
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.24462762
19* Salmonella infection_Homo sapiens_hsa051322.20030625
20Pertussis_Homo sapiens_hsa051332.14300905
21* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051422.10536331
22Staphylococcus aureus infection_Homo sapiens_hsa051502.05586976
23Intestinal immune network for IgA production_Homo sapiens_hsa046722.03832810
24* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.87818149
25Hematopoietic cell lineage_Homo sapiens_hsa046401.87409954
26Other glycan degradation_Homo sapiens_hsa005111.85669697
27Tuberculosis_Homo sapiens_hsa051521.76616876
28Influenza A_Homo sapiens_hsa051641.73945402
29Antigen processing and presentation_Homo sapiens_hsa046121.73747913
30Lysosome_Homo sapiens_hsa041421.72004712
31Primary immunodeficiency_Homo sapiens_hsa053401.58132402
32Measles_Homo sapiens_hsa051621.57663287
33Prion diseases_Homo sapiens_hsa050201.42656274
34Herpes simplex infection_Homo sapiens_hsa051681.35002447
35Toxoplasmosis_Homo sapiens_hsa051451.33929205
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.27568553
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.26034078
38T cell receptor signaling pathway_Homo sapiens_hsa046601.24522325
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18279439
40* Chemokine signaling pathway_Homo sapiens_hsa040621.18142144
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.16797838
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.11207579
43Hepatitis C_Homo sapiens_hsa051601.10330164
44Viral myocarditis_Homo sapiens_hsa054161.05863572
45Hepatitis B_Homo sapiens_hsa051610.96985725
46Amoebiasis_Homo sapiens_hsa051460.95873565
47Shigellosis_Homo sapiens_hsa051310.95244190
48Phagosome_Homo sapiens_hsa041450.90546201
49Apoptosis_Homo sapiens_hsa042100.89641712
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86372052
51Adipocytokine signaling pathway_Homo sapiens_hsa049200.81759133
52Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80680730
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79780675
54B cell receptor signaling pathway_Homo sapiens_hsa046620.79744782
55Epstein-Barr virus infection_Homo sapiens_hsa051690.77617966
56Bladder cancer_Homo sapiens_hsa052190.77581904
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67448150
58Type II diabetes mellitus_Homo sapiens_hsa049300.66065645
59Collecting duct acid secretion_Homo sapiens_hsa049660.65277567
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63772042
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62034277
62Complement and coagulation cascades_Homo sapiens_hsa046100.57580404
63Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53775831
64Prolactin signaling pathway_Homo sapiens_hsa049170.53048104
65Systemic lupus erythematosus_Homo sapiens_hsa053220.52030798
66HTLV-I infection_Homo sapiens_hsa051660.49900154
67VEGF signaling pathway_Homo sapiens_hsa043700.48746038
68Sulfur metabolism_Homo sapiens_hsa009200.46495241
69Sphingolipid metabolism_Homo sapiens_hsa006000.45616820
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39200305
71Acute myeloid leukemia_Homo sapiens_hsa052210.38593372
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35955497
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35413832
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.34760457
75Vibrio cholerae infection_Homo sapiens_hsa051100.30417422
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27726844
77Viral carcinogenesis_Homo sapiens_hsa052030.25112464
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22742079
79Insulin resistance_Homo sapiens_hsa049310.18604547
80Tryptophan metabolism_Homo sapiens_hsa003800.18418428
81Mineral absorption_Homo sapiens_hsa049780.17832356
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.14530121
83HIF-1 signaling pathway_Homo sapiens_hsa040660.13248640
84MAPK signaling pathway_Homo sapiens_hsa040100.13063387
85Proteasome_Homo sapiens_hsa030500.12162310
86Galactose metabolism_Homo sapiens_hsa000520.12062077
87Endocytosis_Homo sapiens_hsa041440.11299816
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.10751211
89Fructose and mannose metabolism_Homo sapiens_hsa000510.08980303
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.06863432
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.02912734
92PPAR signaling pathway_Homo sapiens_hsa033200.02778397
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.02390171
94FoxO signaling pathway_Homo sapiens_hsa040680.01793134
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.01079727
96Fatty acid biosynthesis_Homo sapiens_hsa000610.00213730
97Chronic myeloid leukemia_Homo sapiens_hsa05220-0.0332416
98Small cell lung cancer_Homo sapiens_hsa05222-0.0210076
99Dorso-ventral axis formation_Homo sapiens_hsa04320-0.0202367
100Notch signaling pathway_Homo sapiens_hsa04330-0.0106443

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