CCL3L3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vitamin D biosynthetic process (GO:0060556)6.36242195
2regulation of chronic inflammatory response (GO:0002676)5.86178353
3positive regulation of heat generation (GO:0031652)5.42907636
4regulation of fever generation (GO:0031620)5.34474395
5regulation of vitamin metabolic process (GO:0030656)5.04713854
6regulation of cytokine secretion involved in immune response (GO:0002739)4.98564123
7positive regulation of chemokine biosynthetic process (GO:0045080)4.93348322
8regulation of T-helper 1 cell differentiation (GO:0045625)4.89874797
9lipopolysaccharide-mediated signaling pathway (GO:0031663)4.76666911
10negative regulation of interleukin-12 production (GO:0032695)4.72760350
11regulation of mononuclear cell migration (GO:0071675)4.54789808
12regulation of chemokine biosynthetic process (GO:0045073)4.54349937
13response to peptidoglycan (GO:0032494)4.36056669
14regulation of podosome assembly (GO:0071801)4.35059075
15type I interferon signaling pathway (GO:0060337)4.24766140
16cellular response to type I interferon (GO:0071357)4.24766140
17monocyte chemotaxis (GO:0002548)4.23088178
18response to type I interferon (GO:0034340)4.18184608
19regulation of interferon-alpha production (GO:0032647)4.16397709
20regulation of heat generation (GO:0031650)4.16009976
21eosinophil chemotaxis (GO:0048245)4.13580035
22positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.07631893
23myeloid dendritic cell differentiation (GO:0043011)4.04751566
24activation of MAPKKK activity (GO:0000185)4.03801311
25negative regulation of cytokine production involved in immune response (GO:0002719)3.96594082
26positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.90872150
27regulation of immunoglobulin secretion (GO:0051023)3.78378660
28response to protozoan (GO:0001562)3.77201129
29positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.73989452
30negative regulation of viral genome replication (GO:0045071)3.69756619
31NIK/NF-kappaB signaling (GO:0038061)3.69741899
32branching involved in labyrinthine layer morphogenesis (GO:0060670)3.68710328
33regulation of membrane protein ectodomain proteolysis (GO:0051043)3.67821802
34eosinophil migration (GO:0072677)3.66940088
35positive regulation of NF-kappaB import into nucleus (GO:0042346)3.63921036
36immunoglobulin mediated immune response (GO:0016064)3.59178883
37defense response to protozoan (GO:0042832)3.57360919
38regulation of lymphocyte chemotaxis (GO:1901623)3.56649139
39negative regulation of nitric oxide biosynthetic process (GO:0045019)3.56530226
40positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.53451316
41myeloid dendritic cell activation (GO:0001773)3.51405652
42macrophage activation involved in immune response (GO:0002281)3.45967487
43T cell migration (GO:0072678)3.43328703
44regulation of nitric oxide biosynthetic process (GO:0045428)3.41680120
45interferon-gamma-mediated signaling pathway (GO:0060333)3.40719970
46positive regulation of gamma-delta T cell activation (GO:0046645)3.40345257
47T-helper 1 type immune response (GO:0042088)3.38753940
48positive regulation of nitric oxide biosynthetic process (GO:0045429)3.37786000
49cellular response to nicotine (GO:0071316)3.34793942
50positive regulation of interferon-alpha production (GO:0032727)3.34468932
51granulocyte activation (GO:0036230)3.33817599
52positive regulation of acute inflammatory response (GO:0002675)3.33127592
53negative regulation of amino acid transport (GO:0051956)3.31772805
54negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.30039846
55cellular response to lipopolysaccharide (GO:0071222)3.27539418
56germinal center formation (GO:0002467)3.25543987
57regulation of interleukin-8 biosynthetic process (GO:0045414)3.25443255
58negative regulation of production of molecular mediator of immune response (GO:0002701)3.21983508
59cellular response to molecule of bacterial origin (GO:0071219)3.14598771
60regulation of heterotypic cell-cell adhesion (GO:0034114)3.14444989
61negative regulation of myeloid cell apoptotic process (GO:0033033)3.12455270
62regulation of interleukin-12 production (GO:0032655)3.12362691
63regulation of NF-kappaB import into nucleus (GO:0042345)3.11905324
64lymphocyte chemotaxis (GO:0048247)3.10401868
65positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.10320878
66positive regulation of type 2 immune response (GO:0002830)3.08545882
67positive regulation of lymphocyte apoptotic process (GO:0070230)3.07665183
68positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.06769624
69positive regulation of lymphocyte migration (GO:2000403)3.06109747
70negative regulation of growth of symbiont in host (GO:0044130)3.05450810
71negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.05450810
72modulation of growth of symbiont involved in interaction with host (GO:0044144)3.05450810
73regulation of growth of symbiont in host (GO:0044126)3.05450810
74positive regulation of interleukin-6 production (GO:0032755)3.04572691
75negative regulation of lipid storage (GO:0010888)3.03183296
76regulation of interleukin-2 biosynthetic process (GO:0045076)3.02184577
77regulation of T-helper cell differentiation (GO:0045622)2.97846063
78dendritic cell differentiation (GO:0097028)2.97186559
79cellular response to interferon-gamma (GO:0071346)2.95306200
80macrophage chemotaxis (GO:0048246)2.94523332
81CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.93126408
82regulation of inflammatory response to antigenic stimulus (GO:0002861)2.91460036
83positive regulation of interleukin-1 beta secretion (GO:0050718)2.90870923
84sarcoplasmic reticulum calcium ion transport (GO:0070296)2.89783692
85positive regulation of defense response to virus by host (GO:0002230)2.88794448
86regulation of interleukin-12 biosynthetic process (GO:0045075)2.88444156
87response to muramyl dipeptide (GO:0032495)2.86052306
88regulation of T-helper 2 cell differentiation (GO:0045628)2.86048808
89regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.85950088
90neutrophil activation involved in immune response (GO:0002283)2.85714569
91oligosaccharide catabolic process (GO:0009313)2.82937349
92regulation of lymphocyte migration (GO:2000401)2.81204899
93regulation of interleukin-1 beta secretion (GO:0050706)2.80733815
94regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.80309321
95regulation of type 2 immune response (GO:0002828)2.79709795
96positive regulation of interferon-beta production (GO:0032728)2.79526824
97virion attachment to host cell (GO:0019062)2.78668061
98adhesion of symbiont to host cell (GO:0044650)2.78668061
99regulation of type I interferon-mediated signaling pathway (GO:0060338)2.78303349
100negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.77542229

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.97486274
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.95791726
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.39146830
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.42712906
5RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human4.32748902
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.72278211
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.69908238
8* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.41033882
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.34935374
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.34701660
11STAT4_19710469_ChIP-ChIP_TH1__Mouse3.14782439
12EGR1_19374776_ChIP-ChIP_THP-1_Human3.03915151
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.02656035
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.81388491
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.81008049
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.66641343
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.52051431
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.40213549
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.19853154
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.17283238
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.03658058
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.01193626
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.00285210
24VDR_24787735_ChIP-Seq_THP-1_Human1.97672389
25BRD4_27068464_Chip-Seq_AML-cells_Mouse1.89320017
26VDR_24763502_ChIP-Seq_THP-1_Human1.77915519
27PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.75133713
28VDR_21846776_ChIP-Seq_THP-1_Human1.68854454
29SPI1_23547873_ChIP-Seq_NB4_Human1.65977660
30RUNX_20019798_ChIP-Seq_JUKART_Human1.64473609
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.61086658
32MYB_26560356_Chip-Seq_TH2_Human1.60070965
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.57820784
34SPI1_23127762_ChIP-Seq_K562_Human1.56933011
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.55202291
36MAF_26560356_Chip-Seq_TH1_Human1.54425973
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.50026285
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.47549159
39SCL_19346495_ChIP-Seq_HPC-7_Human1.46081684
40NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.45991594
41TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45449186
42CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44831838
43LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.41855105
44GATA1_22025678_ChIP-Seq_K562_Human1.35862406
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.32561385
46TP63_17297297_ChIP-ChIP_HaCaT_Human1.32296545
47GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.29994879
48PU_27001747_Chip-Seq_BMDM_Mouse1.28789229
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28732880
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.27619559
51CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23922760
52PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23117013
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20281988
54SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20216480
55PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20034836
56CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19194632
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.19045090
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17457935
59CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16844414
60MYB_26560356_Chip-Seq_TH1_Human1.15735223
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.15015977
62MAF_26560356_Chip-Seq_TH2_Human1.14863900
63UTX_26944678_Chip-Seq_JUKART_Human1.14399615
64CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11237915
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06441818
66FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.06299666
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06277288
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06070188
69LXR_22292898_ChIP-Seq_THP-1_Human1.04671258
70GATA3_27048872_Chip-Seq_THYMUS_Human1.04156422
71VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03492773
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02888424
73KDM2B_26808549_Chip-Seq_DND41_Human1.02176893
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02097399
75STAT1_20625510_ChIP-Seq_HELA_Human1.01081431
76GATA3_26560356_Chip-Seq_TH2_Human0.98866981
77GATA2_21666600_ChIP-Seq_HMVEC_Human0.98186581
78JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96505534
79TCF7_22412390_ChIP-Seq_EML_Mouse0.96475369
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96383010
81KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.95599996
82KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.95599996
83KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.95599996
84GATA1_19941827_ChIP-Seq_MEL_Mouse0.93266103
85JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92402658
86GATA2_22383799_ChIP-Seq_G1ME_Mouse0.91816867
87NOTCH1_21737748_ChIP-Seq_TLL_Human0.90580667
88KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90579813
89GATA1_19941826_ChIP-Seq_K562_Human0.89574777
90TFEB_21752829_ChIP-Seq_HELA_Human0.89196658
91SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88652267
92MYC_22102868_ChIP-Seq_BL_Human0.83661646
93EGR1_19032775_ChIP-ChIP_M12_Human0.81351274
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80051398
95PU.1_20513432_ChIP-Seq_Bcells_Mouse0.78706659
96PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.77119557
97CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.76959468
98BCL6_27268052_Chip-Seq_Bcells_Human0.75472334
99ESR1_21235772_ChIP-Seq_MCF-7_Human0.72429983
100ELF1_20517297_ChIP-Seq_JURKAT_Human0.72378080

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation5.71777648
2MP0006082_CNS_inflammation4.34353210
3MP0002148_abnormal_hypersensitivity_rea3.78131599
4MP0009785_altered_susceptibility_to3.62984016
5MP0003436_decreased_susceptibility_to3.52593682
6MP0004510_myositis3.44157745
7MP0005671_abnormal_response_to3.19038458
8MP0003724_increased_susceptibility_to3.15295479
9MP0005058_abnormal_lysosome_morphology2.97266959
10MP0001835_abnormal_antigen_presentation2.95126824
11MP0005000_abnormal_immune_tolerance2.93332435
12MP0001790_abnormal_immune_system2.72119825
13MP0005387_immune_system_phenotype2.72119825
14MP0002139_abnormal_hepatobiliary_system2.60600158
15MP0009764_decreased_sensitivity_to2.57688139
16MP0005025_abnormal_response_to2.53016760
17MP0002419_abnormal_innate_immunity2.41324161
18MP0003300_gastrointestinal_ulcer2.34566382
19MP0002723_abnormal_immune_serum2.24299371
20MP0001800_abnormal_humoral_immune2.20458024
21MP0003075_altered_response_to2.20180929
22MP0002452_abnormal_antigen_presenting2.15661050
23MP0008004_abnormal_stomach_pH2.15354215
24MP0004947_skin_inflammation2.14260188
25MP0009840_abnormal_foam_cell2.10978252
26MP0001853_heart_inflammation2.02549906
27MP0001533_abnormal_skeleton_physiology1.98467051
28MP0005167_abnormal_blood-brain_barrier1.93675380
29MP0010155_abnormal_intestine_physiology1.89571953
30MP0000343_altered_response_to1.87216398
31MP0006054_spinal_hemorrhage1.85593919
32MP0002420_abnormal_adaptive_immunity1.81106697
33MP0001845_abnormal_inflammatory_respons1.80554454
34MP0001819_abnormal_immune_cell1.80462614
35MP0002332_abnormal_exercise_endurance1.78400849
36MP0005451_abnormal_body_composition1.75618669
37MP0009333_abnormal_splenocyte_physiolog1.74083916
38MP0002254_reproductive_system_inflammat1.73068587
39MP0009278_abnormal_bone_marrow1.70001205
40MP0003448_altered_tumor_morphology1.68258677
41MP0008469_abnormal_protein_level1.64810403
42MP0003453_abnormal_keratinocyte_physiol1.64132881
43MP0003172_abnormal_lysosome_physiology1.63198342
44MP0003806_abnormal_nucleotide_metabolis1.62799544
45MP0002405_respiratory_system_inflammati1.58528319
46MP0005310_abnormal_salivary_gland1.53081504
47MP0000604_amyloidosis1.51972048
48MP0000685_abnormal_immune_system1.46969424
49MP0003195_calcinosis1.44038853
50MP0002998_abnormal_bone_remodeling1.41302697
51MP0005166_decreased_susceptibility_to1.40821413
52MP0003690_abnormal_glial_cell1.35774820
53MP0005397_hematopoietic_system_phenotyp1.33013093
54MP0001545_abnormal_hematopoietic_system1.33013093
55MP0000716_abnormal_immune_system1.30785431
56MP0000858_altered_metastatic_potential1.27229753
57MP0001501_abnormal_sleep_pattern1.14588189
58MP0005464_abnormal_platelet_physiology1.12938265
59MP0002398_abnormal_bone_marrow1.11989859
60MP0003763_abnormal_thymus_physiology1.11760563
61MP0002138_abnormal_hepatobiliary_system1.10756221
62MP0003656_abnormal_erythrocyte_physiolo1.06462491
63MP0009763_increased_sensitivity_to1.05782010
64MP0005165_increased_susceptibility_to0.99589406
65MP0002429_abnormal_blood_cell0.97595652
66MP0001542_abnormal_bone_strength0.95480937
67MP0009765_abnormal_xenobiotic_induced0.94419419
68MP0005164_abnormal_response_to0.93535394
69MP0000689_abnormal_spleen_morphology0.92550778
70MP0000920_abnormal_myelination0.91495347
71MP0002722_abnormal_immune_system0.87645692
72MP0005390_skeleton_phenotype0.86477866
73MP0003646_muscle_fatigue0.84093585
74MP0001873_stomach_inflammation0.83549188
75MP0005647_abnormal_sex_gland0.81410222
76MP0001663_abnormal_digestive_system0.81213829
77MP0010307_abnormal_tumor_latency0.80400835
78MP0002933_joint_inflammation0.76259668
79MP0003091_abnormal_cell_migration0.73931912
80MP0003191_abnormal_cellular_cholesterol0.73147897
81MP0008874_decreased_physiological_sensi0.69867058
82MP0005535_abnormal_body_temperature0.69840384
83MP0005266_abnormal_metabolism0.63092827
84MP0004808_abnormal_hematopoietic_stem0.62337644
85MP0005666_abnormal_adipose_tissue0.59410824
86MP0003183_abnormal_peptide_metabolism0.58990158
87MP0000249_abnormal_blood_vessel0.57674523
88MP0005023_abnormal_wound_healing0.57561015
89MP0003329_amyloid_beta_deposits0.56950256
90MP0003795_abnormal_bone_structure0.55941787
91MP0002837_dystrophic_cardiac_calcinosis0.54891939
92MP0002277_abnormal_respiratory_mucosa0.54788009
93MP0001727_abnormal_embryo_implantation0.54373368
94MP0002693_abnormal_pancreas_physiology0.53581334
95MP0005076_abnormal_cell_differentiation0.52801756
96MP0002877_abnormal_melanocyte_morpholog0.52419796
97MP0004883_abnormal_blood_vessel0.52412623
98MP0001764_abnormal_homeostasis0.50067564
99MP0000609_abnormal_liver_physiology0.49709104
100MP0005595_abnormal_vascular_smooth0.45986432

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)6.98192796
2Abnormality of glycosphingolipid metabolism (HP:0004343)6.98192796
3Abnormality of glycolipid metabolism (HP:0010969)6.98192796
4Optic neuritis (HP:0100653)5.38959842
5Retrobulbar optic neuritis (HP:0100654)5.38959842
6Orchitis (HP:0100796)5.11606650
7Abnormality of macrophages (HP:0004311)4.88655871
8Stomatitis (HP:0010280)4.77770533
9Vacuolated lymphocytes (HP:0001922)4.51951016
10Systemic lupus erythematosus (HP:0002725)4.51857300
11Disinhibition (HP:0000734)4.48038487
12Myositis (HP:0100614)4.47812916
13Recurrent bacterial skin infections (HP:0005406)4.38540999
14Autoimmune thrombocytopenia (HP:0001973)4.31070267
15Loss of speech (HP:0002371)4.27346090
16Increased cerebral lipofuscin (HP:0011813)4.24081361
17Dysostosis multiplex (HP:0000943)4.21593470
18Mediastinal lymphadenopathy (HP:0100721)3.88448287
19Nuclear cataract (HP:0100018)3.87032053
20Recurrent abscess formation (HP:0002722)3.81578626
21Keratoconjunctivitis sicca (HP:0001097)3.69700012
22Mutism (HP:0002300)3.68650791
23Increased neuronal autofluorescent lipopigment (HP:0002074)3.44437441
24Eczematoid dermatitis (HP:0000976)3.40405507
25Keratoconjunctivitis (HP:0001096)3.37714399
26Gangrene (HP:0100758)3.35975555
27Neurofibrillary tangles (HP:0002185)3.32568700
28Pulmonary infiltrates (HP:0002113)3.25815980
29Vasculitis (HP:0002633)3.21412679
30Increased IgM level (HP:0003496)3.15532691
31Abnormality of polysaccharide metabolism (HP:0011012)3.12824386
32Abnormality of glycosaminoglycan metabolism (HP:0004371)3.12824386
33Abnormality of mucopolysaccharide metabolism (HP:0011020)3.12824386
34Autoimmune hemolytic anemia (HP:0001890)3.12758634
35Nausea (HP:0002018)3.05654980
36Parakeratosis (HP:0001036)3.03766210
37T lymphocytopenia (HP:0005403)2.96563120
38Elevated erythrocyte sedimentation rate (HP:0003565)2.95245389
39Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.89074667
40Increased serum ferritin (HP:0003281)2.88276464
41Abnormality of T cell number (HP:0011839)2.82825232
42Urinary glycosaminoglycan excretion (HP:0003541)2.82549680
43Mucopolysacchariduria (HP:0008155)2.82549680
44Glomerulonephritis (HP:0000099)2.80838692
45Apathy (HP:0000741)2.78721260
46Recurrent gram-negative bacterial infections (HP:0005420)2.78074238
47Hemoptysis (HP:0002105)2.69677920
48Recurrent viral infections (HP:0004429)2.69159061
49Axonal loss (HP:0003447)2.67829410
50Diminished motivation (HP:0000745)2.66321841
51Polyneuropathy (HP:0001271)2.65311574
52Agnosia (HP:0010524)2.63450470
53Hematochezia (HP:0002573)2.60378301
54Obstructive lung disease (HP:0006536)2.60166267
55Chronic obstructive pulmonary disease (HP:0006510)2.60166267
56Inappropriate behavior (HP:0000719)2.48870059
57Interstitial pulmonary disease (HP:0006530)2.48253375
58Progressive neurologic deterioration (HP:0002344)2.47897049
59Meningitis (HP:0001287)2.44717037
60Abnormality of the pleura (HP:0002103)2.44621331
61Amyloidosis (HP:0011034)2.44491150
62Arterial thrombosis (HP:0004420)2.42352596
63Encephalitis (HP:0002383)2.42036534
64Joint swelling (HP:0001386)2.39772062
65Purpura (HP:0000979)2.38093179
66Basal ganglia calcification (HP:0002135)2.37072765
67Recurrent skin infections (HP:0001581)2.35275090
68Cerebral inclusion bodies (HP:0100314)2.29390458
69Recurrent fungal infections (HP:0002841)2.27529668
70Hepatosplenomegaly (HP:0001433)2.26943615
71Abnormality of the pericardium (HP:0001697)2.25167667
72Abnormality of iron homeostasis (HP:0011031)2.22075901
73Neuronal loss in central nervous system (HP:0002529)2.21885328
74Anorexia (HP:0002039)2.21792247
75Complement deficiency (HP:0004431)2.20738073
76Hypergammaglobulinemia (HP:0010702)2.20555711
77Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.16671828
78Prolonged neonatal jaundice (HP:0006579)2.16439675
79Abnormality of the vasculature of the conjunctiva (HP:0008054)2.15851874
80IgA deficiency (HP:0002720)2.14679418
81Leukocytosis (HP:0001974)2.13665404
82Metaphyseal irregularity (HP:0003025)2.13222107
83Memory impairment (HP:0002354)2.12421759
84Abnormality of B cell number (HP:0010975)2.11937824
85Personality changes (HP:0000751)2.10850490
86Vertigo (HP:0002321)2.10278435
87Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.05541529
88Petechiae (HP:0000967)2.05392757
89Pulmonary embolism (HP:0002204)2.05358755
90Gastrointestinal stroma tumor (HP:0100723)2.01338599
91Glomerulopathy (HP:0100820)2.00485662
92B lymphocytopenia (HP:0010976)2.00007111
93Arthralgia (HP:0002829)1.99907952
94Myocardial infarction (HP:0001658)1.97445093
95Acne (HP:0001061)1.97020136
96Zonular cataract (HP:0010920)1.96018597
97Gastrointestinal infarctions (HP:0005244)1.93276519
98Combined immunodeficiency (HP:0005387)1.92246180
99Urticaria (HP:0001025)1.91147015
100Restrictive lung disease (HP:0002091)1.89787214

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK35.94170743
2GRK73.81690976
3NME23.62305893
4MAP3K143.52960886
5TAOK23.46339229
6TBK13.10721049
7TXK3.05514373
8DDR22.78558804
9RIPK12.56812470
10MAP4K12.49344519
11IKBKE2.46474492
12IKBKB2.43706263
13MATK2.41571122
14IRAK42.40906019
15TAOK12.39876109
16MAP3K112.38109462
17PIM22.23743137
18BLK2.16393949
19RIPK42.09811403
20MAP3K31.99794455
21BMPR21.98672296
22MOS1.86540257
23ADRBK21.74949906
24TYK21.74280721
25PRPF4B1.72109197
26CSK1.69439958
27FGR1.68043527
28CHUK1.57673876
29JAK31.47204301
30MAP2K31.41239263
31TGFBR21.34074129
32IRAK21.31256061
33IRAK11.20148781
34CDC42BPA1.18216084
35TYRO31.10457155
36MAP3K51.07644334
37ABL21.06069475
38SYK1.04522995
39LYN1.03656348
40MAP3K10.99970312
41ZAP700.98831091
42ACVR1B0.96684895
43JAK10.92413016
44ERN10.87004652
45LATS20.80638772
46LCK0.80010376
47JAK20.78052507
48STK100.77805033
49MAP2K60.75513508
50MARK30.75353305
51PIM10.74715372
52CSF1R0.72355970
53MAP3K130.70353597
54PKN10.67738889
55TESK20.64410487
56CLK10.63709246
57TAOK30.60646681
58BTK0.56122422
59ITK0.54341287
60DYRK30.52935799
61HCK0.47359644
62MAPK40.47151014
63FES0.45795923
64KDR0.41840454
65DAPK30.41428506
66PDGFRA0.41223910
67HIPK20.39755820
68SIK30.39449997
69BMX0.38278682
70ARAF0.37696536
71DAPK20.37352360
72CDK60.35156862
73KIT0.34723885
74TESK10.34467025
75INSR0.33059033
76EIF2AK20.28145063
77PRKCQ0.27027505
78CAMKK20.26640289
79TNK20.26631343
80ABL10.26487537
81SIK20.26300957
82EGFR0.25979318
83MAPK70.25304505
84PDK10.22168015
85PDGFRB0.21964836
86FYN0.21923127
87EPHA30.20781117
88DYRK1B0.18381934
89GSK3A0.16838963
90MAPKAPK20.15951680
91PRKCD0.15894849
92RPS6KC10.15800147
93RPS6KL10.15800147
94CDK140.15399331
95STK240.15241325
96PAK40.13013276
97CDK150.12383161
98ICK0.11954157
99RPS6KA10.11762249
100MAPK30.11635055

Predicted pathways (KEGG)

RankGene SetZ-score
1* Toll-like receptor signaling pathway_Homo sapiens_hsa046203.24120116
2NF-kappa B signaling pathway_Homo sapiens_hsa040643.09130545
3* Rheumatoid arthritis_Homo sapiens_hsa053233.04127230
4Allograft rejection_Homo sapiens_hsa053303.02550718
5Graft-versus-host disease_Homo sapiens_hsa053322.90375825
6Asthma_Homo sapiens_hsa053102.75538309
7NOD-like receptor signaling pathway_Homo sapiens_hsa046212.61440317
8RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.58867976
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.51719388
10TNF signaling pathway_Homo sapiens_hsa046682.51153322
11Malaria_Homo sapiens_hsa051442.51095390
12Osteoclast differentiation_Homo sapiens_hsa043802.47271397
13Leishmaniasis_Homo sapiens_hsa051402.44303190
14Autoimmune thyroid disease_Homo sapiens_hsa053202.33778890
15Legionellosis_Homo sapiens_hsa051342.28887854
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.28017191
17Staphylococcus aureus infection_Homo sapiens_hsa051502.26106924
18Intestinal immune network for IgA production_Homo sapiens_hsa046722.23148374
19African trypanosomiasis_Homo sapiens_hsa051432.17502072
20Other glycan degradation_Homo sapiens_hsa005112.17454962
21Type I diabetes mellitus_Homo sapiens_hsa049402.17066971
22Pertussis_Homo sapiens_hsa051332.13959181
23* Salmonella infection_Homo sapiens_hsa051322.13832311
24* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.91406013
25Lysosome_Homo sapiens_hsa041421.90640091
26Tuberculosis_Homo sapiens_hsa051521.85155034
27Influenza A_Homo sapiens_hsa051641.76758472
28* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.73481872
29Hematopoietic cell lineage_Homo sapiens_hsa046401.66985817
30Antigen processing and presentation_Homo sapiens_hsa046121.61800139
31Measles_Homo sapiens_hsa051621.52133700
32Toxoplasmosis_Homo sapiens_hsa051451.48002256
33Prion diseases_Homo sapiens_hsa050201.43345498
34Primary immunodeficiency_Homo sapiens_hsa053401.42190748
35Herpes simplex infection_Homo sapiens_hsa051681.40307341
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.28524709
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.23975259
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18704278
39Viral myocarditis_Homo sapiens_hsa054161.17706234
40Hepatitis C_Homo sapiens_hsa051601.15615899
41T cell receptor signaling pathway_Homo sapiens_hsa046601.12947750
42* Chemokine signaling pathway_Homo sapiens_hsa040621.11230532
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09857799
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.09686365
45B cell receptor signaling pathway_Homo sapiens_hsa046621.00432629
46Shigellosis_Homo sapiens_hsa051311.00310307
47Hepatitis B_Homo sapiens_hsa051610.99922448
48Phagosome_Homo sapiens_hsa041450.98145127
49Apoptosis_Homo sapiens_hsa042100.93824819
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92775692
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.86214524
52Amoebiasis_Homo sapiens_hsa051460.86047624
53Adipocytokine signaling pathway_Homo sapiens_hsa049200.84478487
54Bladder cancer_Homo sapiens_hsa052190.83284375
55Epstein-Barr virus infection_Homo sapiens_hsa051690.82572532
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81547819
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.78556493
58Collecting duct acid secretion_Homo sapiens_hsa049660.67455960
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67063263
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61545746
61Type II diabetes mellitus_Homo sapiens_hsa049300.60930066
62Sphingolipid metabolism_Homo sapiens_hsa006000.60097816
63Prolactin signaling pathway_Homo sapiens_hsa049170.59022263
64Systemic lupus erythematosus_Homo sapiens_hsa053220.57942789
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57554581
66Complement and coagulation cascades_Homo sapiens_hsa046100.56342529
67Acute myeloid leukemia_Homo sapiens_hsa052210.52912670
68VEGF signaling pathway_Homo sapiens_hsa043700.52909727
69Sulfur metabolism_Homo sapiens_hsa009200.51847090
70HTLV-I infection_Homo sapiens_hsa051660.47373883
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42876946
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.38620291
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36052915
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33845640
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32213669
76Vibrio cholerae infection_Homo sapiens_hsa051100.30086341
77Viral carcinogenesis_Homo sapiens_hsa052030.30050477
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.25722604
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23937573
80MAPK signaling pathway_Homo sapiens_hsa040100.21813685
81Mineral absorption_Homo sapiens_hsa049780.20599660
82Tryptophan metabolism_Homo sapiens_hsa003800.20247669
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.19650606
84HIF-1 signaling pathway_Homo sapiens_hsa040660.19217954
85Insulin resistance_Homo sapiens_hsa049310.15828237
86Galactose metabolism_Homo sapiens_hsa000520.14324866
87Endocytosis_Homo sapiens_hsa041440.12686562
88Chronic myeloid leukemia_Homo sapiens_hsa052200.09854584
89FoxO signaling pathway_Homo sapiens_hsa040680.09087460
90Notch signaling pathway_Homo sapiens_hsa043300.09056561
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.08844858
92PPAR signaling pathway_Homo sapiens_hsa033200.08607005
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.07956863
94Fructose and mannose metabolism_Homo sapiens_hsa000510.05601811
95Renin-angiotensin system_Homo sapiens_hsa046140.04333568
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.00716852
97Dorso-ventral axis formation_Homo sapiens_hsa04320-0.0213987
98Small cell lung cancer_Homo sapiens_hsa05222-0.0083212
99Primary bile acid biosynthesis_Homo sapiens_hsa00120-0.0065140
100Pancreatic cancer_Homo sapiens_hsa05212-0.0022493

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