CCL5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)8.55826403
2cytidine metabolic process (GO:0046087)8.55826403
3cytidine catabolic process (GO:0006216)8.55826403
4pyrimidine ribonucleoside catabolic process (GO:0046133)7.62206577
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.84245300
6DNA deamination (GO:0045006)6.25197920
7regulation of T-helper 1 cell differentiation (GO:0045625)5.63847881
8positive regulation of alpha-beta T cell proliferation (GO:0046641)5.50068096
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.30395070
10regulation of regulatory T cell differentiation (GO:0045589)5.13596772
11positive regulation of type 2 immune response (GO:0002830)5.09523467
12regulation of natural killer cell mediated immunity (GO:0002715)5.09236819
13regulation of natural killer cell mediated cytotoxicity (GO:0042269)5.09236819
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.07809727
15T-helper 1 type immune response (GO:0042088)5.06313121
16cellular response to interleukin-15 (GO:0071350)5.06110888
17type I interferon signaling pathway (GO:0060337)4.95102188
18cellular response to type I interferon (GO:0071357)4.95102188
19regulation of alpha-beta T cell proliferation (GO:0046640)4.94650528
20positive regulation of T-helper cell differentiation (GO:0045624)4.91187631
21positive regulation of natural killer cell differentiation (GO:0032825)4.90759950
22neutrophil activation involved in immune response (GO:0002283)4.89856290
23positive regulation of T cell cytokine production (GO:0002726)4.88786699
24response to type I interferon (GO:0034340)4.87942391
25positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.75244086
26regulation of T-helper 2 cell differentiation (GO:0045628)4.74952442
27regulation of memory T cell differentiation (GO:0043380)4.72215375
28negative thymic T cell selection (GO:0045060)4.71186668
29positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.68218061
30negative T cell selection (GO:0043383)4.62660113
31T cell migration (GO:0072678)4.51661418
32positive regulation of interleukin-12 production (GO:0032735)4.49563085
33regulation of B cell receptor signaling pathway (GO:0050855)4.44692198
34negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.44604248
35negative regulation of cell killing (GO:0031342)4.44604248
36positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.40422254
37response to interleukin-15 (GO:0070672)4.39479644
38positive regulation of interferon-alpha production (GO:0032727)4.36566346
39positive regulation of gamma-delta T cell activation (GO:0046645)4.34520100
40regulation of T cell tolerance induction (GO:0002664)4.33581542
41regulation of leukocyte mediated cytotoxicity (GO:0001910)4.28648675
42myeloid dendritic cell differentiation (GO:0043011)4.26229424
43Arp2/3 complex-mediated actin nucleation (GO:0034314)4.23972041
44positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.23836833
45pyrimidine nucleoside catabolic process (GO:0046135)4.22162334
46antigen processing and presentation of endogenous antigen (GO:0019883)4.21695726
47cellular response to zinc ion (GO:0071294)4.17159042
48regulation of dendritic cell antigen processing and presentation (GO:0002604)4.16797373
49positive regulation of isotype switching (GO:0045830)4.15873275
50positive regulation of defense response to virus by host (GO:0002230)4.13475702
51regulation of T-helper cell differentiation (GO:0045622)4.12044329
52positive regulation of calcium-mediated signaling (GO:0050850)4.10094508
53regulation of interferon-alpha production (GO:0032647)4.09191321
54positive regulation of interleukin-8 secretion (GO:2000484)4.07168297
55positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)4.06902050
56regulation of hypersensitivity (GO:0002883)4.06610590
57positive regulation of tolerance induction (GO:0002645)4.02959492
58regulation of RIG-I signaling pathway (GO:0039535)4.01057557
59natural killer cell mediated cytotoxicity (GO:0042267)3.99171394
60natural killer cell mediated immunity (GO:0002228)3.99171394
61positive regulation of interleukin-17 production (GO:0032740)3.98197194
62regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.98043195
63cellular response to interferon-beta (GO:0035458)3.97894293
64positive regulation of humoral immune response (GO:0002922)3.97757689
65natural killer cell activation (GO:0030101)3.96308081
66regulation of immunoglobulin secretion (GO:0051023)3.95923467
67positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.94910495
68myeloid dendritic cell activation (GO:0001773)3.94081841
69positive regulation of cell killing (GO:0031343)3.93559084
70regulation of cell killing (GO:0031341)3.92424127
71negative regulation of interleukin-17 production (GO:0032700)3.88688967
72antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.88578217
73antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.88578217
74positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.84236580
75positive regulation of interleukin-2 production (GO:0032743)3.83503795
76regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.82844677
77positive regulation of antigen processing and presentation (GO:0002579)3.81867393
78positive T cell selection (GO:0043368)3.80991061
79positive thymic T cell selection (GO:0045059)3.80805412
80cellular response to interferon-alpha (GO:0035457)3.79356890
81positive regulation of DNA recombination (GO:0045911)3.78349360
82regulation of interleukin-2 biosynthetic process (GO:0045076)3.76404383
83regulation of gamma-delta T cell activation (GO:0046643)3.71320927
84T cell costimulation (GO:0031295)3.71166641
85* regulation of activation of Janus kinase activity (GO:0010533)3.71044483
86regulation of gamma-delta T cell differentiation (GO:0045586)3.68849298
87regulation of T-helper 1 type immune response (GO:0002825)3.66949324
88actin nucleation (GO:0045010)3.66684824
89lymphocyte costimulation (GO:0031294)3.66088345
90response to interferon-alpha (GO:0035455)3.64609942
91regulation of isotype switching to IgG isotypes (GO:0048302)3.63323662
92natural killer cell differentiation (GO:0001779)3.61733044
93* negative regulation of viral genome replication (GO:0045071)3.60550493
94positive regulation of B cell differentiation (GO:0045579)3.59150107
95defense response to protozoan (GO:0042832)3.56714885
96interferon-gamma-mediated signaling pathway (GO:0060333)3.54933941
97regulation of T cell cytokine production (GO:0002724)3.54629742
98positive regulation of B cell mediated immunity (GO:0002714)3.53706192
99positive regulation of immunoglobulin mediated immune response (GO:0002891)3.53706192
100lymphocyte migration (GO:0072676)3.53680801
101regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.53367723
102positive regulation of interleukin-10 production (GO:0032733)3.52692694
103positive regulation of T cell mediated cytotoxicity (GO:0001916)3.52292808
104regulation of T cell mediated cytotoxicity (GO:0001914)3.51923032
105cellular defense response (GO:0006968)3.51181460
106response to peptidoglycan (GO:0032494)3.49901462
107positive regulation of activated T cell proliferation (GO:0042104)3.49869523
108regulation of interleukin-12 production (GO:0032655)3.49774601
109regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.49503047
110regulation of tolerance induction (GO:0002643)3.49459184
111cellular response to exogenous dsRNA (GO:0071360)3.48593058
112interferon-gamma production (GO:0032609)3.48174341
113* granulocyte activation (GO:0036230)3.47549638
114lymphocyte chemotaxis (GO:0048247)3.45504773
115regulation of interleukin-17 production (GO:0032660)3.45070546
116regulation of T cell receptor signaling pathway (GO:0050856)3.41026097
117negative regulation of B cell proliferation (GO:0030889)3.39704323
118regulation of interleukin-12 biosynthetic process (GO:0045075)3.38266405
119regulation of interferon-gamma biosynthetic process (GO:0045072)3.37048674
120positive regulation of response to tumor cell (GO:0002836)3.36703876
121positive regulation of immune response to tumor cell (GO:0002839)3.36703876
122regulation of immune response to tumor cell (GO:0002837)3.36703876
123regulation of response to tumor cell (GO:0002834)3.36703876
124regulation of B cell differentiation (GO:0045577)3.35110238
125cytolysis (GO:0019835)3.34333235
126immunoglobulin mediated immune response (GO:0016064)3.33647342
127positive regulation of natural killer cell mediated immunity (GO:0002717)3.33518234
128positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.33518234
129* neutrophil activation (GO:0042119)3.33397372
130positive regulation of interferon-gamma production (GO:0032729)3.32926231
131positive regulation of alpha-beta T cell differentiation (GO:0046638)3.31653976
132positive regulation of response to biotic stimulus (GO:0002833)3.30700396
133T-helper cell differentiation (GO:0042093)3.30676948
134CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.30676948
135regulation of antigen processing and presentation (GO:0002577)3.30503796
136regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.30304649
137response to interferon-beta (GO:0035456)3.29505495
138activated T cell proliferation (GO:0050798)3.28905480
139NIK/NF-kappaB signaling (GO:0038061)3.27651630
140T cell receptor signaling pathway (GO:0050852)3.26938451
141thymic T cell selection (GO:0045061)3.24103759
142dendritic cell differentiation (GO:0097028)3.22695520
143cellular response to virus (GO:0098586)3.22486737
144regulation of calcium-mediated signaling (GO:0050848)3.17005899
145positive regulation of lymphocyte mediated immunity (GO:0002708)3.15882763
146T cell selection (GO:0045058)3.15512199
147negative regulation of interleukin-12 production (GO:0032695)3.13402297
148regulation of interleukin-8 secretion (GO:2000482)3.04107063
149* negative regulation of viral process (GO:0048525)3.02868519
150negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.02329331
151B cell mediated immunity (GO:0019724)3.01697273
152* negative regulation of T cell apoptotic process (GO:0070233)3.00829976
153antigen receptor-mediated signaling pathway (GO:0050851)3.00577120
154regulation of vitamin D biosynthetic process (GO:0060556)2.95490138
155regulation of defense response to virus by host (GO:0050691)2.95475365
156* regulation of viral genome replication (GO:0045069)2.95354439
157positive regulation of macrophage differentiation (GO:0045651)2.90779576
158regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.88870539
159negative regulation of T cell receptor signaling pathway (GO:0050860)2.88766303
160positive regulation of interleukin-1 beta secretion (GO:0050718)2.87328016
161negative regulation of T cell activation (GO:0050868)2.87104405
162regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.84381687
163negative regulation of B cell activation (GO:0050869)2.84333757
164positive regulation of leukocyte mediated immunity (GO:0002705)2.79405924
165regulation of lymphocyte mediated immunity (GO:0002706)2.78712095
166antigen processing and presentation via MHC class Ib (GO:0002475)2.78304549
167leukocyte degranulation (GO:0043299)2.77729835

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human8.43641499
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.93530542
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human6.37685516
4* IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.72764102
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.63904720
6BP1_19119308_ChIP-ChIP_Hs578T_Human5.63434258
7* IRF8_27001747_Chip-Seq_BMDM_Mouse3.92501159
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.92482546
9STAT4_19710469_ChIP-ChIP_TH1__Mouse3.50352114
10* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.39838348
11* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.32897909
12* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.12373787
13* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.00298670
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.93018423
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.87384006
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.54102027
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.10642235
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.06748991
19* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.06613134
20MYB_26560356_Chip-Seq_TH2_Human2.04272064
21RUNX_20019798_ChIP-Seq_JUKART_Human2.03089060
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.98056422
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90871314
24* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.79567128
25SPI1_23547873_ChIP-Seq_NB4_Human1.76596729
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.75608320
27MAF_26560356_Chip-Seq_TH1_Human1.70326662
28MYB_26560356_Chip-Seq_TH1_Human1.66154407
29TP63_17297297_ChIP-ChIP_HaCaT_Human1.55312768
30VDR_24787735_ChIP-Seq_THP-1_Human1.52523367
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.52112684
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.47192276
33* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47175166
34CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.46384116
35CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46243530
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.42945708
37PU_27001747_Chip-Seq_BMDM_Mouse1.39401694
38GATA3_26560356_Chip-Seq_TH2_Human1.38204570
39PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37632431
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37569684
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.35448711
42VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.30870702
43PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29129394
44CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26879759
45GATA1_22025678_ChIP-Seq_K562_Human1.25469935
46* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.25439406
47EGR1_19032775_ChIP-ChIP_M12_Human1.24470156
48* GATA3_27048872_Chip-Seq_THYMUS_Human1.22077946
49CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22061861
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.21484508
51PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15793654
52CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.15712323
53BCL6_27268052_Chip-Seq_Bcells_Human1.13131986
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12764494
55RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10927769
56SPI1_23127762_ChIP-Seq_K562_Human1.09543903
57* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08114812
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07297951
59TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.06726598
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.04563770
61HTT_18923047_ChIP-ChIP_STHdh_Human1.03900500
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99449400
63VDR_24763502_ChIP-Seq_THP-1_Human0.99193982
64MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.98375481
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98274968
66PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97777753
67* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96171539
68ELF1_20517297_ChIP-Seq_JURKAT_Human0.95890197
69TAF2_19829295_ChIP-Seq_ESCs_Human0.95071942
70SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90822984
71STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90422462
72STAT6_21828071_ChIP-Seq_BEAS2B_Human0.89871523
73EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.89609430
74GATA3_26560356_Chip-Seq_TH1_Human0.89526428
75EGR1_23403033_ChIP-Seq_LIVER_Mouse0.88519452
76GATA1_19941826_ChIP-Seq_K562_Human0.87845593
77LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87799300
78RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.87302031
79* NANOG_20526341_ChIP-Seq_ESCs_Human0.86922130
80SA1_27219007_Chip-Seq_Bcells_Human0.86049866
81STAT1_20625510_ChIP-Seq_HELA_Human0.85226287
82MAF_26560356_Chip-Seq_TH2_Human0.85213813
83* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.84393855
84GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.83403176
85* BCOR_27268052_Chip-Seq_Bcells_Human0.83389754
86RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.82581801
87YY1_22570637_ChIP-Seq_MALME-3M_Human0.82408914
88SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.81417922
89UTX_26944678_Chip-Seq_JUKART_Human0.80914547
90PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80890141
91GATA2_22383799_ChIP-Seq_G1ME_Mouse0.80317667
92FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.79450295
93SRY_22984422_ChIP-ChIP_TESTIS_Rat0.78968380
94GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.77770954
95SMRT_27268052_Chip-Seq_Bcells_Human0.76992122
96* P300_27268052_Chip-Seq_Bcells_Human0.76107062
97GATA2_21666600_ChIP-Seq_HMVEC_Human0.75687627
98FLI1_27457419_Chip-Seq_LIVER_Mouse0.75656375
99TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.74981156
100RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.74225171
101CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.73704244
102SCL_19346495_ChIP-Seq_HPC-7_Human0.73266274
103CTCF_20526341_ChIP-Seq_ESCs_Human0.73027221
104GATA6_21074721_ChIP-Seq_CACO-2_Human0.72696819
105CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.72614935
106NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.72348882
107NRF2_20460467_ChIP-Seq_MEFs_Mouse0.72348882
108PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.71877571
109CDX2_19796622_ChIP-Seq_MESCs_Mouse0.71284358
110GATA3_21878914_ChIP-Seq_MCF-7_Human0.69647426
111GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69623351
112NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.69028841
113* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68652527
114PCGF2_27294783_Chip-Seq_ESCs_Mouse0.67785682
115BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.67548445
116PRDM14_20953172_ChIP-Seq_ESCs_Human0.67175509
117SOX2_20726797_ChIP-Seq_SW620_Human0.66398334
118P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.66343808
119E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.64802835
120TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.64326857
121KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.63877845
122PU.1_20513432_ChIP-Seq_Bcells_Mouse0.62215526
123IKZF1_21737484_ChIP-ChIP_HCT116_Human0.61245111
124NMYC_18555785_Chip-Seq_ESCs_Mouse0.60271181
125GATA1_19941827_ChIP-Seq_MEL_Mouse0.59988468
126CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.59040327
127PU1_27457419_Chip-Seq_LIVER_Mouse0.58386878
128CMYC_18555785_Chip-Seq_ESCs_Mouse0.56418212
129SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.56294399
130SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.56294399
131STAT3_18555785_Chip-Seq_ESCs_Mouse0.56181502
132JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.55243793
133JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.54759552
134SUZ12_18555785_Chip-Seq_ESCs_Mouse0.52654046
135SMAD1_18555785_Chip-Seq_ESCs_Mouse0.52594489
136BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.52395042
137KAP1_22055183_ChIP-Seq_ESCs_Mouse0.50775408
138RUNX1_27457419_Chip-Seq_LIVER_Mouse0.50399139
139VDR_21846776_ChIP-Seq_THP-1_Human0.50292214
140CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.49817516

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.37120085
2MP0009785_altered_susceptibility_to4.65817955
3MP0005671_abnormal_response_to4.57304637
4* MP0002148_abnormal_hypersensitivity_rea4.22366988
5MP0000685_abnormal_immune_system4.20829811
6MP0006082_CNS_inflammation3.80131366
7MP0003436_decreased_susceptibility_to3.54251520
8MP0001790_abnormal_immune_system3.53663766
9MP0005387_immune_system_phenotype3.53663766
10MP0005000_abnormal_immune_tolerance3.46509585
11MP0005025_abnormal_response_to3.23753365
12MP0003724_increased_susceptibility_to2.89662168
13MP0001800_abnormal_humoral_immune2.82473831
14* MP0002723_abnormal_immune_serum2.77686769
15MP0002419_abnormal_innate_immunity2.70022665
16MP0002452_abnormal_antigen_presenting2.70005061
17MP0002006_tumorigenesis2.62785458
18MP0001348_abnormal_lacrimal_gland2.61047758
19MP0004510_myositis2.59672931
20MP0002163_abnormal_gland_morphology2.57984869
21* MP0001819_abnormal_immune_cell2.50632346
22* MP0002420_abnormal_adaptive_immunity2.44321938
23MP0005310_abnormal_salivary_gland2.18286495
24MP0002166_altered_tumor_susceptibility2.17791733
25MP0003763_abnormal_thymus_physiology1.95173140
26MP0002138_abnormal_hepatobiliary_system1.91034324
27MP0002405_respiratory_system_inflammati1.89677080
28MP0001346_abnormal_lacrimal_gland1.87751540
29MP0009764_decreased_sensitivity_to1.87671270
30* MP0000716_abnormal_immune_system1.87154095
31MP0001845_abnormal_inflammatory_respons1.83338770
32* MP0002398_abnormal_bone_marrow1.83245317
33MP0004947_skin_inflammation1.78787538
34MP0001853_heart_inflammation1.78382667
35MP0001533_abnormal_skeleton_physiology1.76522424
36MP0003448_altered_tumor_morphology1.75796250
37MP0010155_abnormal_intestine_physiology1.65120550
38MP0008469_abnormal_protein_level1.61483506
39MP0000858_altered_metastatic_potential1.54611259
40MP0003300_gastrointestinal_ulcer1.51496253
41MP0005464_abnormal_platelet_physiology1.50792020
42MP0003303_peritoneal_inflammation1.47531427
43MP0009333_abnormal_splenocyte_physiolog1.46600305
44* MP0002429_abnormal_blood_cell1.41403375
45MP0008004_abnormal_stomach_pH1.40438138
46MP0000569_abnormal_digit_pigmentation1.38660708
47MP0002722_abnormal_immune_system1.31075001
48MP0005379_endocrine/exocrine_gland_phen1.29283633
49MP0002277_abnormal_respiratory_mucosa1.27856986
50MP0000689_abnormal_spleen_morphology1.25585715
51MP0002009_preneoplasia1.16841780
52MP0002998_abnormal_bone_remodeling1.16269862
53MP0004782_abnormal_surfactant_physiolog1.06830628
54MP0001919_abnormal_reproductive_system1.05551545
55MP0005058_abnormal_lysosome_morphology1.05466723
56MP0009763_increased_sensitivity_to0.97903561
57MP0003806_abnormal_nucleotide_metabolis0.97845761
58MP0003186_abnormal_redox_activity0.95522334
59MP0000703_abnormal_thymus_morphology0.92958805
60MP0003195_calcinosis0.92162133
61MP0002254_reproductive_system_inflammat0.91905459
62MP0005397_hematopoietic_system_phenotyp0.89185412
63MP0001545_abnormal_hematopoietic_system0.89185412
64MP0005166_decreased_susceptibility_to0.88314358
65MP0003075_altered_response_to0.87140721
66MP0002933_joint_inflammation0.84656535
67MP0003183_abnormal_peptide_metabolism0.84070157
68MP0001501_abnormal_sleep_pattern0.83583362
69MP0000465_gastrointestinal_hemorrhage0.82550708
70MP0000343_altered_response_to0.81632944
71MP0003091_abnormal_cell_migration0.80610231
72MP0003191_abnormal_cellular_cholesterol0.78459941
73MP0001663_abnormal_digestive_system0.77517238
74MP0001873_stomach_inflammation0.76326087
75MP0005390_skeleton_phenotype0.74394895
76MP0003045_fibrosis0.73577084
77MP0001542_abnormal_bone_strength0.71896822
78MP0010386_abnormal_urinary_bladder0.70281550
79MP0008057_abnormal_DNA_replication0.69665080
80MP0005451_abnormal_body_composition0.66918341
81MP0005076_abnormal_cell_differentiation0.66663824
82MP0008873_increased_physiological_sensi0.66263290
83MP0000604_amyloidosis0.65664571
84MP0004130_abnormal_muscle_cell0.65495093
85MP0005410_abnormal_fertilization0.65203443
86MP0002876_abnormal_thyroid_physiology0.65139158
87MP0001881_abnormal_mammary_gland0.64827784
88MP0002136_abnormal_kidney_physiology0.64713791
89MP0003866_abnormal_defecation0.64186579
90MP0009278_abnormal_bone_marrow0.63315356
91MP0009840_abnormal_foam_cell0.62840991
92MP0003172_abnormal_lysosome_physiology0.62837791
93MP0003453_abnormal_keratinocyte_physiol0.62695402
94MP0002132_abnormal_respiratory_system0.62551268
95MP0005165_increased_susceptibility_to0.61639014
96MP0005164_abnormal_response_to0.61137266
97MP0008874_decreased_physiological_sensi0.60243506
98MP0009643_abnormal_urine_homeostasis0.59402560
99MP0002332_abnormal_exercise_endurance0.58897704
100MP0004381_abnormal_hair_follicle0.58882878
101MP0000371_diluted_coat_color0.58560536
102MP0004883_abnormal_blood_vessel0.58201036
103MP0002019_abnormal_tumor_incidence0.57582731
104MP0002693_abnormal_pancreas_physiology0.57512022
105MP0000249_abnormal_blood_vessel0.57387385
106MP0005174_abnormal_tail_pigmentation0.56698079
107MP0003646_muscle_fatigue0.56185010
108MP0000627_abnormal_mammary_gland0.54470238
109MP0003566_abnormal_cell_adhesion0.54019358
110MP0001905_abnormal_dopamine_level0.51657005
111MP0001765_abnormal_ion_homeostasis0.50143250
112MP0000372_irregular_coat_pigmentation0.49730437
113MP0000613_abnormal_salivary_gland0.49683058
114MP0010307_abnormal_tumor_latency0.48890381
115MP0009765_abnormal_xenobiotic_induced0.48481923
116MP0005389_reproductive_system_phenotype0.47938514
117MP0002139_abnormal_hepatobiliary_system0.46567524
118MP0000230_abnormal_systemic_arterial0.46512703
119MP0001191_abnormal_skin_condition0.45749557
120MP0000920_abnormal_myelination0.45371944
121MP0004808_abnormal_hematopoietic_stem0.45369380
122MP0005167_abnormal_blood-brain_barrier0.43508718
123MP0005584_abnormal_enzyme/coenzyme_acti0.41287769
124MP0003690_abnormal_glial_cell0.39953326
125MP0002877_abnormal_melanocyte_morpholog0.39759023
126MP0000490_abnormal_crypts_of0.38881086
127MP0001851_eye_inflammation0.38627042
128MP0005535_abnormal_body_temperature0.35685659

Predicted human phenotypes

RankGene SetZ-score
1Increased IgM level (HP:0003496)7.29361406
2Autoimmune thrombocytopenia (HP:0001973)6.04893294
3Eczematoid dermatitis (HP:0000976)6.01898365
4Recurrent abscess formation (HP:0002722)5.79257320
5Recurrent bacterial skin infections (HP:0005406)5.58567319
6Elevated erythrocyte sedimentation rate (HP:0003565)5.42250647
7Optic neuritis (HP:0100653)5.36378334
8Retrobulbar optic neuritis (HP:0100654)5.36378334
9Orchitis (HP:0100796)5.00361659
10Abnormality of T cell number (HP:0011839)4.95119646
11Gastrointestinal infarctions (HP:0005244)4.84501116
12Myositis (HP:0100614)4.80323290
13Recurrent gram-negative bacterial infections (HP:0005420)4.70044458
14Vasculitis (HP:0002633)4.64340896
15Mediastinal lymphadenopathy (HP:0100721)4.57681287
16Abnormality of macrophages (HP:0004311)4.32276298
17T lymphocytopenia (HP:0005403)4.18162355
18Hypergammaglobulinemia (HP:0010702)4.13650381
19Hypoproteinemia (HP:0003075)4.06162610
20Recurrent fungal infections (HP:0002841)4.03603051
21Basal ganglia calcification (HP:0002135)3.97424444
22Aplastic anemia (HP:0001915)3.90017737
23Recurrent viral infections (HP:0004429)3.80981883
24Autoimmune hemolytic anemia (HP:0001890)3.79318798
25Stomatitis (HP:0010280)3.68320357
26Chronic otitis media (HP:0000389)3.66151934
27Recurrent skin infections (HP:0001581)3.65747499
28Nasal polyposis (HP:0100582)3.38192953
29Pulmonary infiltrates (HP:0002113)3.35915940
30Abnormality of T cells (HP:0002843)3.34554396
31Gingivitis (HP:0000230)3.33277898
32Systemic lupus erythematosus (HP:0002725)3.26562614
33Joint swelling (HP:0001386)3.21914673
34Keratoconjunctivitis sicca (HP:0001097)3.20555659
35Abnormal delayed hypersensitivity skin test (HP:0002963)3.16782053
36Hemoptysis (HP:0002105)3.14361919
37Chronic obstructive pulmonary disease (HP:0006510)3.13058351
38Obstructive lung disease (HP:0006536)3.13058351
39Chronic mucocutaneous candidiasis (HP:0002728)3.05350971
40Recurrent cutaneous fungal infections (HP:0011370)3.05350971
41Pustule (HP:0200039)3.04398967
42Porencephaly (HP:0002132)3.04156170
43Arterial thrombosis (HP:0004420)3.02084622
44Periodontitis (HP:0000704)2.99771310
45Hemiplegia (HP:0002301)2.97530952
46Tetraparesis (HP:0002273)2.96320443
47Keratoconjunctivitis (HP:0001096)2.93757435
48Meningitis (HP:0001287)2.91853892
49Abnormality of the prostate (HP:0008775)2.87662592
50Eosinophilia (HP:0001880)2.85781626
51Leukocytosis (HP:0001974)2.85658450
52Abnormality of glycolipid metabolism (HP:0010969)2.84736659
53Abnormality of liposaccharide metabolism (HP:0010968)2.84736659
54Abnormality of glycosphingolipid metabolism (HP:0004343)2.84736659
55IgG deficiency (HP:0004315)2.82191766
56Gangrene (HP:0100758)2.80698951
57Interstitial pulmonary disease (HP:0006530)2.80102943
58Anorexia (HP:0002039)2.79168064
59Abnormality of the nasal mucosa (HP:0000433)2.79050430
60Increased serum ferritin (HP:0003281)2.74373317
61Recurrent bronchitis (HP:0002837)2.71077890
62Encephalitis (HP:0002383)2.66056987
63Prolonged bleeding time (HP:0003010)2.65974027
64Abnormality of eosinophils (HP:0001879)2.65649867
65Abnormality of T cell physiology (HP:0011840)2.63693643
66Epistaxis (HP:0000421)2.62457252
67Combined immunodeficiency (HP:0005387)2.56760891
68IgA deficiency (HP:0002720)2.53976275
69Abnormality of the pericardium (HP:0001697)2.53762204
70Prolonged neonatal jaundice (HP:0006579)2.53044829
71Purpura (HP:0000979)2.51910850
72Abnormality of B cell number (HP:0010975)2.50531762
73Urticaria (HP:0001025)2.47265171
74Cleft eyelid (HP:0000625)2.44588951
75Thick nail (HP:0001805)2.42203022
76Gingival bleeding (HP:0000225)2.38352648
77Recurrent pneumonia (HP:0006532)2.37837035
78Severe combined immunodeficiency (HP:0004430)2.36781349
79Abnormality of iron homeostasis (HP:0011031)2.36203173
80Poor head control (HP:0002421)2.33325107
81Petechiae (HP:0000967)2.33058451
82Granulocytopenia (HP:0001913)2.31958061
83Cellulitis (HP:0100658)2.31071412
84Amaurosis fugax (HP:0100576)2.29116839
85Keratitis (HP:0000491)2.26735907
86Abnormality of the pleura (HP:0002103)2.25453903
87Abnormality of cells of the lymphoid lineage (HP:0012140)2.24975052
88Chest pain (HP:0100749)2.24024530
89Recurrent lower respiratory tract infections (HP:0002783)2.23782804
90Chronic sinusitis (HP:0011109)2.22153569
91Arthralgia (HP:0002829)2.22144067
92Hypoalbuminemia (HP:0003073)2.21849378
93Abnormal albumin level (HP:0012116)2.21849378
94Agammaglobulinemia (HP:0004432)2.21527427
95Prostate neoplasm (HP:0100787)2.21430408
96Abnormality of transition element cation homeostasis (HP:0011030)2.21241728
97Polyneuropathy (HP:0001271)2.20148161
983-Methylglutaconic aciduria (HP:0003535)2.18546604
99Increased cerebral lipofuscin (HP:0011813)2.17910779
100Increased neuronal autofluorescent lipopigment (HP:0002074)2.17896237
101Lymphoma (HP:0002665)2.17678692
102Vacuolated lymphocytes (HP:0001922)2.17551857
103Thyroiditis (HP:0100646)2.16537338
104Lower limb hyperreflexia (HP:0002395)2.16178708
105Hypochromic anemia (HP:0001931)2.11068613
106Cerebral ischemia (HP:0002637)2.10712201
107Hypoplasia of the thymus (HP:0000778)2.06084010
108Chronic diarrhea (HP:0002028)2.05425337
109Premature loss of primary teeth (HP:0006323)2.04433093
110Episodic fever (HP:0001954)2.02993804
111Hepatosplenomegaly (HP:0001433)2.02910424
112Ureteral stenosis (HP:0000071)2.02791901
113Osteolytic defects of the phalanges of the hand (HP:0009771)2.02154642
114Osteolytic defects of the hand bones (HP:0009699)2.02154642
115Abnormality of the endocardium (HP:0004306)2.01669267
116Tetraplegia (HP:0002445)2.01150786
117Glomerulopathy (HP:0100820)1.99054023
118Vertebral compression fractures (HP:0002953)1.98380054
119Acute hepatic failure (HP:0006554)1.97606528
120Lymphopenia (HP:0001888)1.96601416
121Hemorrhage of the eye (HP:0011885)1.96390957
122Neutropenia (HP:0001875)1.95733429
123IgM deficiency (HP:0002850)1.94793720
124Skin ulcer (HP:0200042)1.91745822
125B lymphocytopenia (HP:0010976)1.90572088
126Ureteral obstruction (HP:0006000)1.88370287
127Pulmonary fibrosis (HP:0002206)1.87743202
128Dysostosis multiplex (HP:0000943)1.86683319
129Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.86392324
130Pulmonary embolism (HP:0002204)1.86034062
131J-shaped sella turcica (HP:0002680)1.85459932
132Spontaneous hematomas (HP:0007420)1.85417850
133Skin rash (HP:0000988)1.84854861
134Bronchitis (HP:0012387)1.84461243
135Osteomyelitis (HP:0002754)1.84000133
136Increased IgE level (HP:0003212)1.83852765
137Thrombocytosis (HP:0001894)1.83194173

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.42914460
2KDR3.93378183
3JAK33.92515828
4TBK13.81064865
5PBK3.72005875
6TYK23.58732273
7IKBKE3.15859073
8TESK23.11265506
9IKBKB3.09000515
10IRAK42.99543574
11TXK2.94069223
12RIPK42.92085558
13JAK12.65458174
14MAP3K132.60371582
15BLK2.50559180
16MST42.21805781
17CHUK2.15882994
18MAP4K12.09478726
19PIM22.08887338
20BMPR22.02182609
21CSK1.80596373
22NEK91.78412714
23SYK1.59608905
24TYRO31.50903139
25BCKDK1.49006318
26TLK11.47332914
27ZAP701.46755195
28BCR1.45267365
29IRAK31.44891989
30ARAF1.40201462
31SIK31.36843494
32FGFR41.36508831
33DAPK21.35961267
34PIM11.32466735
35STK41.27295482
36EPHB11.22234346
37KIT1.18156771
38EIF2AK21.18015776
39NUAK11.17576784
40MAPKAPK31.15925367
41LCK1.15715634
42MAP3K121.09506089
43PRKCQ1.04459724
44FGFR31.04305639
45HCK1.02372538
46ITK1.02192894
47BMX1.00358250
48ABL20.99952235
49TESK10.99658714
50BTK0.96222128
51JAK20.95365937
52TNK20.94280057
53CAMKK20.94109145
54RPS6KA40.90408302
55LYN0.87599471
56MARK30.87123705
57IRAK10.85056672
58CLK10.79908348
59NME20.78892809
60TAOK20.76744195
61EPHA30.75624532
62WNK40.75543372
63ZAK0.74699206
64SIK20.72348043
65PIK3CA0.71326587
66YES10.70101889
67ADRBK20.69420326
68PRKCD0.66513450
69IRAK20.65679448
70ERBB30.65578691
71GRK50.65467707
72LIMK10.65041396
73TEC0.64751006
74TGFBR20.61232921
75GRK10.60853133
76MYLK0.60435950
77NLK0.60154848
78TRPM70.59163148
79PIK3CG0.57667490
80TAOK30.57558632
81MAP3K50.54255740
82ABL10.54212841
83PDK10.54182552
84PDGFRB0.53641130
85ACVR1B0.53619141
86MST1R0.52834407
87STK240.51599280
88STK100.49592952
89GRK70.46889193
90STK30.46787975
91CSF1R0.46755738
92PKN10.45408926
93FRK0.44849655
94FES0.44562114
95RAF10.44450686
96DAPK10.42584799
97MAPKAPK20.41585460
98MOS0.38004114
99PRKCH0.34970809
100ADRBK10.34642482
101PAK10.34502659
102GRK60.33601036
103MAP3K30.33417065
104ERN10.33239095
105DAPK30.32748502
106MAP3K10.32707718
107PRKCA0.30835107
108EGFR0.30559326
109MAP4K20.28411186
110LRRK20.27561982
111CAMK2A0.25934403
112TAOK10.25757627
113RPS6KA10.25447258
114VRK10.24126228
115CDK40.23934899
116FLT30.23723577
117FGR0.23628891
118PTK60.23450245
119MATK0.22443219
120MAPK110.22215593
121IGF1R0.21513667
122ROCK10.20377905
123PRKCE0.20066428
124DMPK0.19489546
125ERBB20.17899272
126PRKACA0.17778501
127PTK2B0.17740638
128INSR0.17739347
129FYN0.17434244
130PRKACG0.17373869
131PRKCB0.16788353
132MAP3K110.16708463
133ILK0.16647098
134RPS6KA50.14130486
135BMPR1B0.13733041
136SRC0.13299547
137KSR20.12683208
138MAP2K60.11897643
139RIPK10.09546906

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053325.61599591
2Allograft rejection_Homo sapiens_hsa053304.99799690
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.29644469
4Type I diabetes mellitus_Homo sapiens_hsa049403.23452757
5Autoimmune thyroid disease_Homo sapiens_hsa053203.00172749
6* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.72254950
7Leishmaniasis_Homo sapiens_hsa051402.67928597
8* Toll-like receptor signaling pathway_Homo sapiens_hsa046202.56466407
9RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.49656969
10Measles_Homo sapiens_hsa051622.49477506
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.44249601
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.38213453
13Primary immunodeficiency_Homo sapiens_hsa053402.18080937
14Viral myocarditis_Homo sapiens_hsa054161.92794025
15Legionellosis_Homo sapiens_hsa051341.90213139
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.89935117
17Antigen processing and presentation_Homo sapiens_hsa046121.89254862
18Pertussis_Homo sapiens_hsa051331.85385678
19* NOD-like receptor signaling pathway_Homo sapiens_hsa046211.83880180
20* Influenza A_Homo sapiens_hsa051641.82340336
21* Rheumatoid arthritis_Homo sapiens_hsa053231.78214164
22Asthma_Homo sapiens_hsa053101.77752063
23Staphylococcus aureus infection_Homo sapiens_hsa051501.76015781
24Malaria_Homo sapiens_hsa051441.75484862
25* TNF signaling pathway_Homo sapiens_hsa046681.71653321
26African trypanosomiasis_Homo sapiens_hsa051431.70864495
27Osteoclast differentiation_Homo sapiens_hsa043801.69742676
28* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.68129590
29* Herpes simplex infection_Homo sapiens_hsa051681.61227519
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.48883707
31Tuberculosis_Homo sapiens_hsa051521.48831028
32Toxoplasmosis_Homo sapiens_hsa051451.48150533
33* Chemokine signaling pathway_Homo sapiens_hsa040621.45736866
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.31101143
35T cell receptor signaling pathway_Homo sapiens_hsa046601.25100251
36Salmonella infection_Homo sapiens_hsa051321.22681506
37Apoptosis_Homo sapiens_hsa042101.20480643
38* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12861464
39Shigellosis_Homo sapiens_hsa051311.11189012
40Hematopoietic cell lineage_Homo sapiens_hsa046401.09150028
41B cell receptor signaling pathway_Homo sapiens_hsa046621.04788592
42Hepatitis B_Homo sapiens_hsa051610.98156708
43Hepatitis C_Homo sapiens_hsa051600.89358969
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81167846
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80502979
46Proteasome_Homo sapiens_hsa030500.78572773
47Phagosome_Homo sapiens_hsa041450.72758229
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72315028
49Prolactin signaling pathway_Homo sapiens_hsa049170.70275831
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69503536
51Linoleic acid metabolism_Homo sapiens_hsa005910.68377447
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.64808804
53Lysosome_Homo sapiens_hsa041420.63322928
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61355613
55Oxidative phosphorylation_Homo sapiens_hsa001900.61217177
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59458269
57Amoebiasis_Homo sapiens_hsa051460.59164485
58* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59085794
59Acute myeloid leukemia_Homo sapiens_hsa052210.56455072
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55304104
61Epstein-Barr virus infection_Homo sapiens_hsa051690.54584579
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47755534
63Parkinsons disease_Homo sapiens_hsa050120.47108486
64Phototransduction_Homo sapiens_hsa047440.46381175
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44756255
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43319995
67Chronic myeloid leukemia_Homo sapiens_hsa052200.42512760
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.42076995
69Pancreatic cancer_Homo sapiens_hsa052120.41584325
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40869953
71Arachidonic acid metabolism_Homo sapiens_hsa005900.40311575
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40270575
73Nitrogen metabolism_Homo sapiens_hsa009100.40122537
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39807877
75Sulfur metabolism_Homo sapiens_hsa009200.38157472
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37040273
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36393987
78HTLV-I infection_Homo sapiens_hsa051660.36229249
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.31763557
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.31368131
81Platelet activation_Homo sapiens_hsa046110.29708472
82Viral carcinogenesis_Homo sapiens_hsa052030.29551919
83p53 signaling pathway_Homo sapiens_hsa041150.27189810
84Caffeine metabolism_Homo sapiens_hsa002320.26965882
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.24909439
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.24831487
87Olfactory transduction_Homo sapiens_hsa047400.24280586
88ABC transporters_Homo sapiens_hsa020100.24144620
89Small cell lung cancer_Homo sapiens_hsa052220.23432949
90Alzheimers disease_Homo sapiens_hsa050100.23338907
91Type II diabetes mellitus_Homo sapiens_hsa049300.23273346
92Collecting duct acid secretion_Homo sapiens_hsa049660.22280977
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20427117
94VEGF signaling pathway_Homo sapiens_hsa043700.20159965
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19047323
96HIF-1 signaling pathway_Homo sapiens_hsa040660.18991882
97Ether lipid metabolism_Homo sapiens_hsa005650.16874169
98Peroxisome_Homo sapiens_hsa041460.15950740
99Other glycan degradation_Homo sapiens_hsa005110.15777070
100Dorso-ventral axis formation_Homo sapiens_hsa043200.15426989
101Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.14674096
102* Prion diseases_Homo sapiens_hsa050200.14500820
103Regulation of autophagy_Homo sapiens_hsa041400.13734232
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.13708997
105FoxO signaling pathway_Homo sapiens_hsa040680.13477939
106Phenylalanine metabolism_Homo sapiens_hsa003600.08588088
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.06662332
108Complement and coagulation cascades_Homo sapiens_hsa046100.06511100
109Notch signaling pathway_Homo sapiens_hsa043300.06105702
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.05765371
111Mineral absorption_Homo sapiens_hsa049780.05434903
112MAPK signaling pathway_Homo sapiens_hsa040100.05084123
113ErbB signaling pathway_Homo sapiens_hsa040120.04530060
114Bladder cancer_Homo sapiens_hsa052190.04298187
115Proteoglycans in cancer_Homo sapiens_hsa052050.03478658
116Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.03339273
117Steroid hormone biosynthesis_Homo sapiens_hsa001400.03260355
118Chemical carcinogenesis_Homo sapiens_hsa052040.03026998
119Tryptophan metabolism_Homo sapiens_hsa003800.02644435
120Morphine addiction_Homo sapiens_hsa050320.02264532
121Insulin resistance_Homo sapiens_hsa049310.02125868
122Adherens junction_Homo sapiens_hsa045200.01019572
123Endocytosis_Homo sapiens_hsa041440.00885374
124Pathways in cancer_Homo sapiens_hsa05200-0.0321704
125Ras signaling pathway_Homo sapiens_hsa04014-0.0320363
126Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0180065
127Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0001983

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