CCL7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* eosinophil chemotaxis (GO:0048245)7.54094480
2* eosinophil migration (GO:0072677)6.48281619
3neutrophil activation involved in immune response (GO:0002283)6.43440473
4cellular response to zinc ion (GO:0071294)6.28998542
5phagocytosis, engulfment (GO:0006911)6.19544306
6regulation of mononuclear cell migration (GO:0071675)6.05529838
7regulation of macrophage chemotaxis (GO:0010758)5.74655830
8negative regulation of interleukin-12 production (GO:0032695)5.63406828
9negative regulation of leukocyte chemotaxis (GO:0002689)5.62628590
10positive regulation of monocyte chemotaxis (GO:0090026)5.43624728
11pinocytosis (GO:0006907)5.32384828
12cellular response to cadmium ion (GO:0071276)4.97128154
13cellular extravasation (GO:0045123)4.89716359
14negative regulation of myeloid cell apoptotic process (GO:0033033)4.86780974
15microglial cell activation (GO:0001774)4.74398904
16regulation of monocyte chemotaxis (GO:0090025)4.73264957
17regulation of vitamin D biosynthetic process (GO:0060556)4.68357117
18cellular response to thyroid hormone stimulus (GO:0097067)4.45719235
19positive regulation of macrophage differentiation (GO:0045651)4.30025377
20immunoglobulin mediated immune response (GO:0016064)4.16391494
21macrophage activation (GO:0042116)4.12893031
22macrophage activation involved in immune response (GO:0002281)4.05463958
23* monocyte chemotaxis (GO:0002548)4.05417412
24positive regulation of osteoblast proliferation (GO:0033690)4.03843782
25positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.02326605
26glycosphingolipid catabolic process (GO:0046479)3.98438963
27membrane invagination (GO:0010324)3.95791040
28lymphocyte chemotaxis (GO:0048247)3.92790841
29positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.91664163
30positive regulation by symbiont of host defense response (GO:0052509)3.84263660
31modulation by symbiont of host defense response (GO:0052031)3.84263660
32modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.84263660
33modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.84263660
34positive regulation by organism of defense response of other organism involved in symbiotic interact3.84263660
35modulation by symbiont of host immune response (GO:0052553)3.84263660
36regulation of integrin-mediated signaling pathway (GO:2001044)3.73946835
37regulation of vitamin metabolic process (GO:0030656)3.65473998
38response to peptidoglycan (GO:0032494)3.61791677
39positive regulation of gamma-delta T cell activation (GO:0046645)3.61602498
40glycolipid catabolic process (GO:0019377)3.56920560
41regulation of apoptotic cell clearance (GO:2000425)3.50699892
42lipopolysaccharide-mediated signaling pathway (GO:0031663)3.49845606
43positive regulation of p38MAPK cascade (GO:1900745)3.49742926
44positive regulation of toll-like receptor signaling pathway (GO:0034123)3.48929861
45macrophage chemotaxis (GO:0048246)3.48714089
46cyclooxygenase pathway (GO:0019371)3.48213818
47positive regulation of type 2 immune response (GO:0002830)3.47093926
48positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.43922583
49barbed-end actin filament capping (GO:0051016)3.43017645
50response to thyroid hormone (GO:0097066)3.41694379
51oligosaccharide catabolic process (GO:0009313)3.41619572
52negative regulation of mast cell activation (GO:0033004)3.40140310
53neutrophil migration (GO:1990266)3.40069190
54regulation of dendritic cell antigen processing and presentation (GO:0002604)3.39423746
55* regulation of lymphocyte migration (GO:2000401)3.37689764
56regulation of podosome assembly (GO:0071801)3.34586198
57regulation of hypersensitivity (GO:0002883)3.33983101
58negative regulation of interleukin-17 production (GO:0032700)3.33014919
59positive regulation of heat generation (GO:0031652)3.28519876
60response to muramyl dipeptide (GO:0032495)3.26437788
61lipoxygenase pathway (GO:0019372)3.26233439
62positive regulation of smooth muscle cell migration (GO:0014911)3.26162334
63positive regulation of phagocytosis (GO:0050766)3.25186047
64positive regulation of acute inflammatory response (GO:0002675)3.23860331
65regulation of MHC class II biosynthetic process (GO:0045346)3.23303279
66regulation of cholesterol storage (GO:0010885)3.22147318
67positive regulation of chemokine biosynthetic process (GO:0045080)3.21348212
68cellular response to lipopolysaccharide (GO:0071222)3.21308900
69myeloid cell activation involved in immune response (GO:0002275)3.21039983
70negative regulation of granulocyte differentiation (GO:0030853)3.20730264
71extracellular fibril organization (GO:0043206)3.20655885
72interferon-gamma-mediated signaling pathway (GO:0060333)3.20601459
73neutrophil activation (GO:0042119)3.20557503
74respiratory burst (GO:0045730)3.19530758
75ceramide catabolic process (GO:0046514)3.19275873
76granulocyte activation (GO:0036230)3.19081372
77positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.18970615
78regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.17981875
79macrophage differentiation (GO:0030225)3.15850925
80cellular response to molecule of bacterial origin (GO:0071219)3.15375637
81positive regulation of mast cell activation (GO:0033005)3.13305076
82regulation of fever generation (GO:0031620)3.13258930
83regulation of vascular endothelial growth factor production (GO:0010574)3.11226080
84positive regulation of chemokine secretion (GO:0090197)3.10210841
85myeloid dendritic cell differentiation (GO:0043011)3.09775886
86positive regulation of macrophage cytokine production (GO:0060907)3.09107516
87* granulocyte chemotaxis (GO:0071621)3.08960868
88regulation of macrophage derived foam cell differentiation (GO:0010743)3.08357996
89B cell mediated immunity (GO:0019724)3.08032020
90regulation of T-helper 2 cell differentiation (GO:0045628)3.06742384
91fibril organization (GO:0097435)3.06379334
92positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.05498658
93antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.04392343
94regulation of mast cell degranulation (GO:0043304)3.04333435
95negative regulation of systemic arterial blood pressure (GO:0003085)3.03946316
96sexual reproduction (GO:0019953)3.03254413
97positive regulation of calcium ion import (GO:0090280)3.03150003
98production of molecular mediator involved in inflammatory response (GO:0002532)3.02955370
99apoptotic cell clearance (GO:0043277)3.02356504
100* regulation of lymphocyte chemotaxis (GO:1901623)3.02052732
101positive regulation of cellular amide metabolic process (GO:0034250)3.01349728
102regulation of macrophage differentiation (GO:0045649)2.99786206
103regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.99278889
104positive regulation of NF-kappaB import into nucleus (GO:0042346)2.99218938
105positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.99135926
106osteoclast differentiation (GO:0030316)2.99092782
107detection of molecule of bacterial origin (GO:0032490)2.98900463
108NIK/NF-kappaB signaling (GO:0038061)2.97968806
109intracellular pH reduction (GO:0051452)2.96744114
110decidualization (GO:0046697)2.96174056
111membrane lipid catabolic process (GO:0046466)2.95450134
112positive regulation of mast cell activation involved in immune response (GO:0033008)2.95293179
113positive regulation of mast cell degranulation (GO:0043306)2.95293179
114positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.95257547
115positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.93466730
116* granulocyte migration (GO:0097530)2.93204524
117T-helper 1 type immune response (GO:0042088)2.92871931
118cellular response to ATP (GO:0071318)2.91350379
119positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.90859250
120detection of external biotic stimulus (GO:0098581)2.90162011
121cell adhesion mediated by integrin (GO:0033627)2.89850253
122response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.89391648
123response to host immune response (GO:0052572)2.89391648
124phagosome maturation (GO:0090382)2.88525167
125response to interferon-gamma (GO:0034341)2.86871060
126cellular response to interferon-gamma (GO:0071346)2.86344321
127regulation of granulocyte chemotaxis (GO:0071622)2.85072798
128negative regulation of leukocyte migration (GO:0002686)2.84933492
129glial cell migration (GO:0008347)2.84578574
130* positive regulation of leukocyte migration (GO:0002687)2.84414267
131regulation of antigen processing and presentation (GO:0002577)2.83799883
132sphingolipid catabolic process (GO:0030149)2.82143565
133regulation of myeloid cell apoptotic process (GO:0033032)2.82070940
134regulation of mast cell activation involved in immune response (GO:0033006)2.81880469
135regulation of interferon-alpha production (GO:0032647)2.80793332
136dermatan sulfate biosynthetic process (GO:0030208)2.79903836
137regulation of T cell migration (GO:2000404)2.77450590
138positive regulation of interferon-alpha production (GO:0032727)2.77421798
139response to laminar fluid shear stress (GO:0034616)2.77342583
140positive regulation of antigen processing and presentation (GO:0002579)2.76956574
141negative regulation of chemotaxis (GO:0050922)2.76772068
142negative regulation of biomineral tissue development (GO:0070168)2.74392744
143* positive regulation of leukocyte chemotaxis (GO:0002690)2.73320758
144T cell migration (GO:0072678)2.72017992
145positive regulation of SMAD protein import into nucleus (GO:0060391)2.70920327
146regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.70858705
147vagina development (GO:0060068)2.70826295
148regulation of phagocytosis (GO:0050764)2.69750892
149production of molecular mediator of immune response (GO:0002440)2.68878374
150positive regulation of cAMP-mediated signaling (GO:0043950)2.67515820
151substrate-dependent cell migration (GO:0006929)2.67198012
152* regulation of leukocyte chemotaxis (GO:0002688)2.66698414
153negative regulation of alcohol biosynthetic process (GO:1902931)2.62956698
154response to fluid shear stress (GO:0034405)2.62572867
155positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.62029793
156* regulation of leukocyte migration (GO:0002685)2.60113488
157neutrophil chemotaxis (GO:0030593)2.58967304
158positive regulation of astrocyte differentiation (GO:0048711)2.57200592
159negative regulation of smooth muscle cell migration (GO:0014912)2.56029654

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.77922671
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.57616424
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.84005710
4* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.73710441
5* IRF8_27001747_Chip-Seq_BMDM_Mouse3.70262136
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.37440591
7Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.32816167
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.15793483
9TP63_17297297_ChIP-ChIP_HaCaT_Human3.05253580
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.89778154
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.62668500
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.53328313
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.51690363
14GATA1_22025678_ChIP-Seq_K562_Human2.50593785
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.32436601
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.29637873
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.27648861
18WT1_19549856_ChIP-ChIP_CCG9911_Human2.25837670
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.21413144
20CJUN_26792858_Chip-Seq_BT549_Human2.05920244
21PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.97727801
22EGR1_19032775_ChIP-ChIP_M12_Human1.94905114
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.87925466
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.86632768
25CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.86228287
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.83730316
27MYB_21317192_ChIP-Seq_ERMYB_Mouse1.80237487
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.80036949
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.76403611
30VDR_24787735_ChIP-Seq_THP-1_Human1.71410632
31VDR_21846776_ChIP-Seq_THP-1_Human1.71073997
32NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.68818925
33CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.68081579
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.63708599
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.63347239
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62161538
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.60978686
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59923838
39* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.59907341
40ESR1_20079471_ChIP-ChIP_T-47D_Human1.55470551
41* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.52437945
42MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.51189487
43TP53_18474530_ChIP-ChIP_U2OS_Human1.49894319
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.49534500
45IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.48984239
46KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.48943400
47KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.48943400
48KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.48943400
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.47274120
50* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.44940212
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.44855352
52NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40882494
53NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40882494
54TP53_16413492_ChIP-PET_HCT116_Human1.39600396
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39172780
56* PU_27001747_Chip-Seq_BMDM_Mouse1.37667236
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37587136
58CLOCK_20551151_ChIP-Seq_293T_Human1.36346162
59TFEB_21752829_ChIP-Seq_HELA_Human1.36159263
60RUNX_20019798_ChIP-Seq_JUKART_Human1.35411165
61PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32084881
62* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30857132
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25066650
64CDX2_20551321_ChIP-Seq_CACO-2_Human1.23301386
65STAT4_19710469_ChIP-ChIP_TH1__Mouse1.23240640
66BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22701750
67E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22405872
68CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22333504
69IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.21284369
70VDR_24763502_ChIP-Seq_THP-1_Human1.20764261
71MAF_26560356_Chip-Seq_TH1_Human1.20447952
72* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20415278
73MYB_26560356_Chip-Seq_TH2_Human1.19452070
74SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.18754093
75* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18283631
76* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17510639
77ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.17233106
78* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16585686
79SPI1_23127762_ChIP-Seq_K562_Human1.16537263
80SCL_19346495_ChIP-Seq_HPC-7_Human1.14916370
81SOX2_20726797_ChIP-Seq_SW620_Human1.14088743
82HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10858097
83LXR_22292898_ChIP-Seq_THP-1_Human1.10742320
84SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10079413
85STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09856336
86TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09855538
87GATA1_19941827_ChIP-Seq_MEL_Mouse1.09595766
88STAT1_20625510_ChIP-Seq_HELA_Human1.08775760
89ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.08189550
90ELK3_25401928_ChIP-Seq_HUVEC_Human1.05249649
91PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04813977
92* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03526028
93FOXO3_23340844_ChIP-Seq_DLD1_Human1.02862790
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02163913
95GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02065383
96* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01557253
97SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01312959
98SPI1_23547873_ChIP-Seq_NB4_Human1.01200805
99FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.00304380
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97577984
101UTX_26944678_Chip-Seq_JUKART_Human0.97477433
102KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97052622
103SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96610310
104FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96221217
105* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95313890
106* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94998519
107SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.94174886
108GATA3_26560356_Chip-Seq_TH2_Human0.92497101
109CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.92422531
110AR_21572438_ChIP-Seq_LNCaP_Human0.90969442
111SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90947218
112GATA3_27048872_Chip-Seq_THYMUS_Human0.89846212
113* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88937789
114SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88759477
115EGR1_19374776_ChIP-ChIP_THP-1_Human0.88577240
116NR3C1_23031785_ChIP-Seq_PC12_Mouse0.87196114
117TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.86480506
118* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.85174049
119MYB_26560356_Chip-Seq_TH1_Human0.84945730
120BCL6_27268052_Chip-Seq_Bcells_Human0.84688299
121BCOR_27268052_Chip-Seq_Bcells_Human0.83016733
122ESR2_21235772_ChIP-Seq_MCF-7_Human0.82944264
123SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.81724792
124* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.81652253
125SALL4_18804426_ChIP-ChIP_XEN_Mouse0.81254308
126SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.79524126
127SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.79524126
128CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.79499699
129SMAD3_21741376_ChIP-Seq_HESCs_Human0.79365575
130ZNF217_24962896_ChIP-Seq_MCF-7_Human0.78930859
131PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.78235339
132TCF7_22412390_ChIP-Seq_EML_Mouse0.77926442
133SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77850896
134ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.77577349
135MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.76509401
136P63_26484246_Chip-Seq_KERATINOCYTES_Human0.76440831
137TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.76344262
138GATA2_19941826_ChIP-Seq_K562_Human0.75922784
139SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.75678673
140GATA1_19941826_ChIP-Seq_K562_Human0.75347977
141GATA1_22383799_ChIP-Seq_G1ME_Mouse0.74985570
142MAF_26560356_Chip-Seq_TH2_Human0.73701034
143VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.69307417
144KDM2B_26808549_Chip-Seq_DND41_Human0.69212396
145RXR_22158963_ChIP-Seq_LIVER_Mouse0.68197495
146ELF1_20517297_ChIP-Seq_JURKAT_Human0.67672548
147CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.67370464

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.45337138
2MP0003279_aneurysm3.78086389
3MP0009840_abnormal_foam_cell3.65718795
4MP0002148_abnormal_hypersensitivity_rea3.56798744
5MP0003436_decreased_susceptibility_to3.47380435
6MP0005275_abnormal_skin_tensile3.25005985
7MP0003705_abnormal_hypodermis_morpholog3.19756861
8MP0005167_abnormal_blood-brain_barrier3.06455046
9MP0005503_abnormal_tendon_morphology3.05046582
10MP0000343_altered_response_to2.94882609
11MP0003303_peritoneal_inflammation2.91128309
12MP0002254_reproductive_system_inflammat2.91088277
13MP0005058_abnormal_lysosome_morphology2.86321759
14MP0009278_abnormal_bone_marrow2.77179035
15MP0002139_abnormal_hepatobiliary_system2.41355207
16MP0010368_abnormal_lymphatic_system2.40798046
17MP0001533_abnormal_skeleton_physiology2.40564279
18MP0002419_abnormal_innate_immunity2.29711164
19MP0009384_cardiac_valve_regurgitation2.27325212
20MP0003950_abnormal_plasma_membrane2.25735107
21MP0005000_abnormal_immune_tolerance2.23131605
22MP0002295_abnormal_pulmonary_circulatio2.20910425
23MP0003806_abnormal_nucleotide_metabolis2.16020786
24MP0001835_abnormal_antigen_presentation2.13997520
25MP0006054_spinal_hemorrhage2.13097672
26MP0003724_increased_susceptibility_to2.11778286
27MP0006082_CNS_inflammation2.06295777
28MP0003191_abnormal_cellular_cholesterol2.00371607
29MP0002837_dystrophic_cardiac_calcinosis1.90955246
30MP0005164_abnormal_response_to1.89036805
31MP0009785_altered_susceptibility_to1.85155547
32MP0003690_abnormal_glial_cell1.83888318
33MP0001958_emphysema1.82044067
34MP0005023_abnormal_wound_healing1.78656638
35MP0009764_decreased_sensitivity_to1.74492208
36MP0000604_amyloidosis1.72777411
37MP0005390_skeleton_phenotype1.72326878
38MP0010352_gastrointestinal_tract_polyps1.66887963
39MP0005171_absent_coat_pigmentation1.66021950
40MP0003195_calcinosis1.65904426
41MP0003075_altered_response_to1.65891466
42MP0000685_abnormal_immune_system1.65846142
43MP0001790_abnormal_immune_system1.63738392
44MP0005387_immune_system_phenotype1.63738392
45MP0002452_abnormal_antigen_presenting1.60628938
46MP0005397_hematopoietic_system_phenotyp1.60307080
47MP0001545_abnormal_hematopoietic_system1.60307080
48MP0002405_respiratory_system_inflammati1.58203594
49MP0005025_abnormal_response_to1.54072984
50MP0005310_abnormal_salivary_gland1.52653854
51MP0003172_abnormal_lysosome_physiology1.52208243
52MP0002998_abnormal_bone_remodeling1.50222380
53MP0004947_skin_inflammation1.49655862
54MP0002723_abnormal_immune_serum1.44263652
55MP0002933_joint_inflammation1.37746897
56MP0005464_abnormal_platelet_physiology1.36740436
57MP0003453_abnormal_keratinocyte_physiol1.35408105
58MP0003656_abnormal_erythrocyte_physiolo1.34757304
59MP0005623_abnormal_meninges_morphology1.34132682
60MP0001800_abnormal_humoral_immune1.31488997
61MP0008260_abnormal_autophagy1.29907122
62MP0001727_abnormal_embryo_implantation1.28536891
63MP0008004_abnormal_stomach_pH1.27153039
64MP0000767_abnormal_smooth_muscle1.21251451
65MP0005671_abnormal_response_to1.19506329
66MP0005257_abnormal_intraocular_pressure1.18871139
67MP0002420_abnormal_adaptive_immunity1.16963566
68MP0003828_pulmonary_edema1.16613409
69MP0005197_abnormal_uvea_morphology1.16058130
70MP0000569_abnormal_digit_pigmentation1.15159486
71MP0005451_abnormal_body_composition1.14582831
72MP0000750_abnormal_muscle_regeneration1.14573025
73MP0003329_amyloid_beta_deposits1.14258728
74MP0001819_abnormal_immune_cell1.13790953
75MP0001845_abnormal_inflammatory_respons1.12364605
76MP0003183_abnormal_peptide_metabolism1.10417238
77MP0003448_altered_tumor_morphology1.10078206
78MP0005508_abnormal_skeleton_morphology1.09655700
79MP0001542_abnormal_bone_strength1.08039113
80MP0000371_diluted_coat_color1.07590207
81MP0002060_abnormal_skin_morphology1.06175145
82MP0000249_abnormal_blood_vessel1.06151806
83MP0004510_myositis1.05104163
84MP0001851_eye_inflammation1.04297783
85MP0005595_abnormal_vascular_smooth1.02648382
86MP0003091_abnormal_cell_migration1.01419703
87MP0002277_abnormal_respiratory_mucosa1.01124336
88MP0003795_abnormal_bone_structure1.00901449
89MP0005166_decreased_susceptibility_to0.98588069
90MP0008469_abnormal_protein_level0.98163585
91MP0009765_abnormal_xenobiotic_induced0.98096725
92MP0005076_abnormal_cell_differentiation0.97752904
93MP0000920_abnormal_myelination0.95351919
94MP0004883_abnormal_blood_vessel0.93566858
95MP0002877_abnormal_melanocyte_morpholog0.93262561
96MP0001879_abnormal_lymphatic_vessel0.90057174
97MP0000858_altered_metastatic_potential0.88816934
98MP0001243_abnormal_dermal_layer0.86548277
99MP0001915_intracranial_hemorrhage0.85076553
100MP0004233_abnormal_muscle_weight0.83728718
101MP0002332_abnormal_exercise_endurance0.82098146
102MP0005165_increased_susceptibility_to0.79122390
103MP0010155_abnormal_intestine_physiology0.77930400
104MP0005388_respiratory_system_phenotype0.77925335
105MP0002133_abnormal_respiratory_system0.77925335
106MP0000516_abnormal_urinary_system0.77361775
107MP0005367_renal/urinary_system_phenotyp0.77361775
108* MP0002429_abnormal_blood_cell0.76012234
109MP0005365_abnormal_bile_salt0.75811687
110MP0002398_abnormal_bone_marrow0.70535814
111MP0001853_heart_inflammation0.69095140
112MP0010307_abnormal_tumor_latency0.68536135
113MP0000465_gastrointestinal_hemorrhage0.66045926
114MP0000015_abnormal_ear_pigmentation0.65815027
115MP0004272_abnormal_basement_membrane0.65501100
116MP0005647_abnormal_sex_gland0.65399903
117MP0000689_abnormal_spleen_morphology0.64200347
118MP0009763_increased_sensitivity_to0.61828904
119MP0002090_abnormal_vision0.61433371
120MP0003634_abnormal_glial_cell0.60329228
121MP0009333_abnormal_splenocyte_physiolog0.60321373
122MP0005319_abnormal_enzyme/_coenzyme0.59144545
123MP0003300_gastrointestinal_ulcer0.58139158
124MP0008874_decreased_physiological_sensi0.58082594
125MP0002896_abnormal_bone_mineralization0.57845989
126MP0001663_abnormal_digestive_system0.57668581
127MP0000609_abnormal_liver_physiology0.57208539
128MP0003633_abnormal_nervous_system0.56808444
129* MP0000716_abnormal_immune_system0.56678971
130MP0001175_abnormal_lung_morphology0.56343768
131MP0001849_ear_inflammation0.55122273
132MP0002396_abnormal_hematopoietic_system0.54953156
133MP0003186_abnormal_redox_activity0.53868652
134MP0002136_abnormal_kidney_physiology0.53282903

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)7.35114684
2Abnormality of liposaccharide metabolism (HP:0010968)7.35114684
3Abnormality of glycosphingolipid metabolism (HP:0004343)7.35114684
4Systemic lupus erythematosus (HP:0002725)5.80583442
5Spontaneous hematomas (HP:0007420)5.39831095
6Protrusio acetabuli (HP:0003179)5.09316416
7Axonal loss (HP:0003447)4.99672044
8Recurrent abscess formation (HP:0002722)4.52236987
9Vertebral compression fractures (HP:0002953)4.49277067
10Glomerulonephritis (HP:0000099)4.29572684
11Premature rupture of membranes (HP:0001788)4.22552137
12Disinhibition (HP:0000734)4.05202361
13Loss of speech (HP:0002371)3.95138282
14Vascular tortuosity (HP:0004948)3.82132176
15Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.81384544
16Vacuolated lymphocytes (HP:0001922)3.81241094
17Arterial tortuosity (HP:0005116)3.78467671
18Prostate neoplasm (HP:0100787)3.77518237
19Osteolytic defects of the hand bones (HP:0009699)3.72512666
20Osteolytic defects of the phalanges of the hand (HP:0009771)3.72512666
21Abnormality of complement system (HP:0005339)3.68038139
22Metaphyseal irregularity (HP:0003025)3.58985000
23Mutism (HP:0002300)3.54305984
24Complement deficiency (HP:0004431)3.52116655
25Atrophic scars (HP:0001075)3.41498385
26Myocardial infarction (HP:0001658)3.40820284
27Increased neuronal autofluorescent lipopigment (HP:0002074)3.25518064
28Fragile skin (HP:0001030)3.23523770
29Soft skin (HP:0000977)3.22243389
30Chronic obstructive pulmonary disease (HP:0006510)3.22023716
31Obstructive lung disease (HP:0006536)3.22023716
32Abnormality of polysaccharide metabolism (HP:0011012)3.20345600
33Abnormality of glycosaminoglycan metabolism (HP:0004371)3.20345600
34Abnormality of mucopolysaccharide metabolism (HP:0011020)3.20345600
35Aortic dissection (HP:0002647)3.16870550
36Agnosia (HP:0010524)3.16464011
37Stomatitis (HP:0010280)3.15120327
38Premature loss of primary teeth (HP:0006323)3.13881910
39Aortic aneurysm (HP:0004942)3.11605416
40Increased cerebral lipofuscin (HP:0011813)3.10296399
41Recurrent bacterial skin infections (HP:0005406)3.08912760
42Dysostosis multiplex (HP:0000943)3.05340875
43Hematochezia (HP:0002573)3.04893062
44Autoimmune thrombocytopenia (HP:0001973)3.04825054
45Increased serum ferritin (HP:0003281)3.03952164
46Peritonitis (HP:0002586)3.02138013
47Eczematoid dermatitis (HP:0000976)2.96516476
48Wormian bones (HP:0002645)2.91853571
49Upper motor neuron abnormality (HP:0002127)2.76869432
50Dilatation of the ascending aorta (HP:0005111)2.75673523
51Cerebral aneurysm (HP:0004944)2.72413874
52Recurrent fungal infections (HP:0002841)2.71542364
53Malnutrition (HP:0004395)2.70081007
54Basal ganglia calcification (HP:0002135)2.69816589
55Pathologic fracture (HP:0002756)2.68886626
56Hemoptysis (HP:0002105)2.68328488
57Neurofibrillary tangles (HP:0002185)2.68281961
58Recurrent cutaneous fungal infections (HP:0011370)2.66447208
59Chronic mucocutaneous candidiasis (HP:0002728)2.66447208
60Peripheral demyelination (HP:0011096)2.65732690
61Bone pain (HP:0002653)2.60077311
62Diminished motivation (HP:0000745)2.59170900
63Joint hemorrhage (HP:0005261)2.56828510
64Retinal atrophy (HP:0001105)2.55087392
65Nephritis (HP:0000123)2.53182660
66Thick nail (HP:0001805)2.52589003
67Segmental peripheral demyelination/remyelination (HP:0003481)2.51993721
68Progressive visual loss (HP:0000529)2.50144010
69Bladder diverticulum (HP:0000015)2.49568081
70Apathy (HP:0000741)2.49043330
71Blue sclerae (HP:0000592)2.48469999
72Abnormality of macrophages (HP:0004311)2.46583271
73Neuronal loss in central nervous system (HP:0002529)2.46477600
74Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.45753082
75Myositis (HP:0100614)2.45540951
76Nausea (HP:0002018)2.44410192
77Abnormality of the vasculature of the conjunctiva (HP:0008054)2.42686951
78Petechiae (HP:0000967)2.42396805
79Abnormality of iron homeostasis (HP:0011031)2.34891678
80Abnormality of the common coagulation pathway (HP:0010990)2.34305288
81Pulmonary infiltrates (HP:0002113)2.33150095
82Conjunctival telangiectasia (HP:0000524)2.28576180
83Albinism (HP:0001022)2.27961895
84Nuclear cataract (HP:0100018)2.27260673
85Urticaria (HP:0001025)2.27228527
86Recurrent gram-negative bacterial infections (HP:0005420)2.26205072
87Orchitis (HP:0100796)2.24167802
88Pustule (HP:0200039)2.22791793
89Facial diplegia (HP:0001349)2.22637054
90Mitral stenosis (HP:0001718)2.18102298
91Supranuclear gaze palsy (HP:0000605)2.14242982
92Abnormality of the phalanges of the 2nd finger (HP:0009541)2.14227733
93Alopecia of scalp (HP:0002293)2.14051821
94Biconcave vertebral bodies (HP:0004586)2.13938909
95Broad ribs (HP:0000885)2.09982366
96Cheilitis (HP:0100825)2.08785232
97Tetraparesis (HP:0002273)2.07043113
98Purpura (HP:0000979)2.06642745
99Recurrent viral infections (HP:0004429)2.05132375
100Mitral valve prolapse (HP:0001634)2.03946205
101Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.02864972
102Spondylolisthesis (HP:0003302)2.02224607
103Hypoalphalipoproteinemia (HP:0003233)1.99552780
104Abnormality of the periventricular white matter (HP:0002518)1.97348458
105Esophageal neoplasm (HP:0100751)1.96847209
106Neoplasm of head and neck (HP:0012288)1.96847209
107Recurrent skin infections (HP:0001581)1.96599159
108Vasculitis (HP:0002633)1.95730763
109Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.94831311
110Bruising susceptibility (HP:0000978)1.94736630
111Abnormality of transition element cation homeostasis (HP:0011030)1.94634987
112Inappropriate behavior (HP:0000719)1.94573610
113Progressive neurologic deterioration (HP:0002344)1.94268177
114Elevated erythrocyte sedimentation rate (HP:0003565)1.92698018
115Dementia (HP:0000726)1.92626984
116Abnormality of the middle phalanges of the toes (HP:0010183)1.90931638
117Thin bony cortex (HP:0002753)1.88423415
118Cerebral inclusion bodies (HP:0100314)1.87946808
119Meningitis (HP:0001287)1.87142399
120Hepatosplenomegaly (HP:0001433)1.86660460
121Protuberant abdomen (HP:0001538)1.86302732
122Short hallux (HP:0010109)1.85972199
123Prolonged neonatal jaundice (HP:0006579)1.85851662
124Gingivitis (HP:0000230)1.85258040
125Colitis (HP:0002583)1.85026394
126Flat occiput (HP:0005469)1.84038743
127Polyneuropathy (HP:0001271)1.82124427
128Genu recurvatum (HP:0002816)1.81228452
129Personality changes (HP:0000751)1.80828441
130Xanthomatosis (HP:0000991)1.78879031
131Keratoconjunctivitis sicca (HP:0001097)1.77096360
132Bone cyst (HP:0012062)1.76693018
133Hyperextensible skin (HP:0000974)1.76414728
134Mucopolysacchariduria (HP:0008155)1.74603448
135Urinary glycosaminoglycan excretion (HP:0003541)1.74603448
136Pulmonary artery stenosis (HP:0004415)1.74589823
137Craniofacial hyperostosis (HP:0004493)1.74445399
138Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.72569800
139Abnormality of the frontal sinuses (HP:0002687)1.71441571
140Corneal dystrophy (HP:0001131)1.71229311
141Mucosal telangiectasiae (HP:0100579)1.70876792
142Retrobulbar optic neuritis (HP:0100654)1.69188053
143Optic neuritis (HP:0100653)1.69188053
144Spinal rigidity (HP:0003306)1.68928871
145Amyloidosis (HP:0011034)1.68046302
146Vaginal fistula (HP:0004320)1.65690833
147Osteomyelitis (HP:0002754)1.64706817
148Mediastinal lymphadenopathy (HP:0100721)1.64382043
149Abnormality of the pericardium (HP:0001697)1.63123320
150Anhidrosis (HP:0000970)1.62708068
151Joint stiffness (HP:0001387)1.61938123

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK5.29917992
2MAP3K104.78984254
3TGFBR24.64593674
4MAP3K143.45742178
5MOS3.39303184
6GRK73.00673390
7EPHB12.52135926
8FGR2.07296178
9PIM22.06592098
10SCYL22.01910397
11TBK11.98176222
12EIF2AK21.96729547
13CAMKK21.92563820
14IKBKB1.87891675
15STK241.84455135
16STK101.80654406
17CAMK1D1.74373245
18FRK1.73914540
19MKNK11.68082648
20MAP2K21.67096172
21IRAK41.66546456
22ERBB31.65848788
23TAOK21.63868485
24MAPKAPK51.58310586
25MAP3K31.52566212
26ERN11.51783028
27TYK21.50012404
28MAP3K131.47733913
29IKBKE1.44370365
30GRK51.43238448
31KIT1.42433327
32PAK41.21768052
33TESK11.18572917
34NEK91.18401034
35IRAK31.18195176
36ACVR1B1.17429211
37CSK1.15842364
38CHUK1.13241792
39FES1.12597187
40TRPM71.11589701
41JAK31.11042537
42PIK3CG1.08429337
43CAMK1G1.08036098
44PRPF4B1.07728201
45BMPR21.07273338
46CDC42BPA1.06346992
47BMPR1B1.05697496
48ADRBK21.04110061
49CLK11.02095121
50TXK1.01978947
51PAK20.98939611
52LATS20.97534573
53MAP3K110.96278635
54TAOK10.96231544
55PTK2B0.94967496
56LYN0.90634274
57NTRK10.90043774
58NLK0.89762446
59DDR20.88606945
60MAPK120.85796687
61LCK0.84449876
62PRKD10.82324323
63MKNK20.81812813
64NME20.81753460
65ZAK0.80581414
66CDK60.80045157
67ABL20.78962851
68TESK20.76563651
69PIM10.76188699
70EPHA30.74447047
71ARAF0.74303119
72TTN0.71687013
73TAOK30.70820669
74EPHB20.70358278
75RPS6KA40.70031788
76KSR10.69932590
77MAP2K10.67700825
78ABL10.67496835
79INSR0.65661864
80ZAP700.65641495
81HCK0.64417726
82MAP3K10.62873691
83JAK10.61954775
84PTK20.61576905
85BMX0.60738282
86EGFR0.58791115
87PKN10.58178462
88SYK0.55983154
89PRKCD0.55594167
90MAP4K10.55220717
91RPS6KC10.55190293
92RPS6KL10.55190293
93MARK30.51580434
94GSK3A0.50787112
95PRKG20.50027820
96KSR20.49579166
97MAPKAPK20.49423783
98DAPK20.48191220
99RIPK40.47451548
100RPS6KA20.47294296
101MAPK40.47052850
102STK38L0.46824034
103IGF1R0.46722736
104PAK30.45747299
105TYRO30.45354514
106PDPK10.45285002
107RPS6KA60.45260993
108IRAK20.43478737
109PAK60.42877716
110DMPK0.42631776
111ADRBK10.41184683
112TEC0.40823519
113MAP2K30.40397589
114LIMK10.39687850
115TGFBR10.39102625
116MAP3K60.37878125
117PAK10.37355765
118PDK10.37275557
119MAP2K60.36972265
120RPS6KA50.36875504
121BTK0.36206279
122FYN0.35405428
123MAP3K50.34914764
124MELK0.34528271
125JAK20.34505898
126PDGFRB0.34300066
127CSF1R0.34170346
128MATK0.34127818
129PBK0.32942143
130DAPK30.32625026
131CAMKK10.30567547
132RIPK10.30508981
133MAPKAPK30.30480913
134ITK0.29794869
135MAP3K80.29611208
136CAMK40.29489763
137STK30.29465656
138PDGFRA0.29270272
139PDK20.29268038
140MAP3K20.27313298
141IRAK10.24443874
142PKN20.21696888
143MAPK110.20535003

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.40836358
2Legionellosis_Homo sapiens_hsa051343.02502306
3Rheumatoid arthritis_Homo sapiens_hsa053232.94637766
4Malaria_Homo sapiens_hsa051442.91135651
5Lysosome_Homo sapiens_hsa041422.64959298
6NOD-like receptor signaling pathway_Homo sapiens_hsa046212.34793548
7Leishmaniasis_Homo sapiens_hsa051402.28994761
8Salmonella infection_Homo sapiens_hsa051322.19621056
9Phagosome_Homo sapiens_hsa041452.15499472
10Complement and coagulation cascades_Homo sapiens_hsa046102.15221266
11Osteoclast differentiation_Homo sapiens_hsa043802.12304095
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.09859105
13Pertussis_Homo sapiens_hsa051332.05539892
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.02837963
15* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.99582296
16Tuberculosis_Homo sapiens_hsa051521.95616560
17* Chemokine signaling pathway_Homo sapiens_hsa040621.81875064
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.81433739
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.81271640
20TNF signaling pathway_Homo sapiens_hsa046681.75004893
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.74085486
22Other glycan degradation_Homo sapiens_hsa005111.54555214
23Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.52303787
24Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.51960640
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.45020953
26Collecting duct acid secretion_Homo sapiens_hsa049661.43561080
27Shigellosis_Homo sapiens_hsa051311.39270719
28Allograft rejection_Homo sapiens_hsa053301.39244345
29Apoptosis_Homo sapiens_hsa042101.36886829
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.35527988
31Graft-versus-host disease_Homo sapiens_hsa053321.35001923
32Arachidonic acid metabolism_Homo sapiens_hsa005901.34989613
33Mineral absorption_Homo sapiens_hsa049781.31868907
34Viral myocarditis_Homo sapiens_hsa054161.31823675
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.31445341
36Caffeine metabolism_Homo sapiens_hsa002321.26231546
37Prion diseases_Homo sapiens_hsa050201.23137455
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22226169
39Toxoplasmosis_Homo sapiens_hsa051451.22192381
40Asthma_Homo sapiens_hsa053101.20342796
41Bladder cancer_Homo sapiens_hsa052191.16862082
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.14369948
43Amoebiasis_Homo sapiens_hsa051461.12555135
44B cell receptor signaling pathway_Homo sapiens_hsa046621.10279223
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98242234
46Hematopoietic cell lineage_Homo sapiens_hsa046400.97782113
47ECM-receptor interaction_Homo sapiens_hsa045120.91648500
48Influenza A_Homo sapiens_hsa051640.91037915
49Measles_Homo sapiens_hsa051620.90961477
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87456232
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86881949
52Sulfur metabolism_Homo sapiens_hsa009200.85558837
53African trypanosomiasis_Homo sapiens_hsa051430.81994024
54Focal adhesion_Homo sapiens_hsa045100.81614260
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75415794
56Hepatitis B_Homo sapiens_hsa051610.73746026
57Autoimmune thyroid disease_Homo sapiens_hsa053200.73339745
58Chronic myeloid leukemia_Homo sapiens_hsa052200.71200491
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.69597621
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68839881
61Proteoglycans in cancer_Homo sapiens_hsa052050.67470190
62Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64130451
63Platelet activation_Homo sapiens_hsa046110.63807372
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.63753695
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63368032
66Antigen processing and presentation_Homo sapiens_hsa046120.63264417
67Small cell lung cancer_Homo sapiens_hsa052220.62766660
68TGF-beta signaling pathway_Homo sapiens_hsa043500.62425517
69Galactose metabolism_Homo sapiens_hsa000520.61641725
70PPAR signaling pathway_Homo sapiens_hsa033200.61445734
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61261424
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60930350
73Endocytosis_Homo sapiens_hsa041440.57662142
74Sphingolipid metabolism_Homo sapiens_hsa006000.56292074
75VEGF signaling pathway_Homo sapiens_hsa043700.56148967
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55153589
77Synaptic vesicle cycle_Homo sapiens_hsa047210.52046767
78Dilated cardiomyopathy_Homo sapiens_hsa054140.51664272
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50808892
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50562764
81Pancreatic cancer_Homo sapiens_hsa052120.50515746
82p53 signaling pathway_Homo sapiens_hsa041150.49467178
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48699534
84Systemic lupus erythematosus_Homo sapiens_hsa053220.48216732
85Type I diabetes mellitus_Homo sapiens_hsa049400.47052352
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.46954442
87Herpes simplex infection_Homo sapiens_hsa051680.45899542
88Melanoma_Homo sapiens_hsa052180.45627769
89Chemical carcinogenesis_Homo sapiens_hsa052040.44061812
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43566282
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42541183
92Acute myeloid leukemia_Homo sapiens_hsa052210.40534785
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.38809839
94Epstein-Barr virus infection_Homo sapiens_hsa051690.38045547
95Renin secretion_Homo sapiens_hsa049240.36770642
96Adherens junction_Homo sapiens_hsa045200.36426502
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36306281
98HIF-1 signaling pathway_Homo sapiens_hsa040660.36149227
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33866384
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.30914604
101Vibrio cholerae infection_Homo sapiens_hsa051100.30226470
102Hepatitis C_Homo sapiens_hsa051600.30110927
103MicroRNAs in cancer_Homo sapiens_hsa052060.30047120
104Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29150214
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.29109418
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.28184232
107Fructose and mannose metabolism_Homo sapiens_hsa000510.28065297
108Rap1 signaling pathway_Homo sapiens_hsa040150.27836880
109Pathways in cancer_Homo sapiens_hsa052000.25856593
110Renal cell carcinoma_Homo sapiens_hsa052110.25552452
111Protein digestion and absorption_Homo sapiens_hsa049740.22202764
112Primary immunodeficiency_Homo sapiens_hsa053400.21695270
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.21365543
114Type II diabetes mellitus_Homo sapiens_hsa049300.21315148
115GnRH signaling pathway_Homo sapiens_hsa049120.21112903
116T cell receptor signaling pathway_Homo sapiens_hsa046600.20731684
117Prolactin signaling pathway_Homo sapiens_hsa049170.16746855
118Notch signaling pathway_Homo sapiens_hsa043300.16566524
119Glutathione metabolism_Homo sapiens_hsa004800.15116398
120Tryptophan metabolism_Homo sapiens_hsa003800.12664107
121HTLV-I infection_Homo sapiens_hsa051660.12347429
122Pentose phosphate pathway_Homo sapiens_hsa000300.11591473
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.06874667
124Renin-angiotensin system_Homo sapiens_hsa046140.05759223
125Viral carcinogenesis_Homo sapiens_hsa052030.03021514

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