CCM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.27291522
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.93303271
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.93303271
4antigen processing and presentation of endogenous antigen (GO:0019883)5.59808254
5regulation of gamma-delta T cell differentiation (GO:0045586)5.21410233
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.17674798
7negative thymic T cell selection (GO:0045060)5.12532606
8negative T cell selection (GO:0043383)5.10545994
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.76109042
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.76109042
11modulation by symbiont of host immune response (GO:0052553)4.76109042
12positive regulation by symbiont of host defense response (GO:0052509)4.76109042
13modulation by symbiont of host defense response (GO:0052031)4.76109042
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.76109042
15regulation of gamma-delta T cell activation (GO:0046643)4.69833764
16regulation of B cell receptor signaling pathway (GO:0050855)4.41214849
17positive thymic T cell selection (GO:0045059)4.40133053
18positive regulation of B cell differentiation (GO:0045579)4.30617654
19Arp2/3 complex-mediated actin nucleation (GO:0034314)4.28242082
20macrophage activation involved in immune response (GO:0002281)4.22029861
21B cell receptor signaling pathway (GO:0050853)4.21844865
22neutrophil activation involved in immune response (GO:0002283)4.20161315
23detection of other organism (GO:0098543)4.17263747
24thymic T cell selection (GO:0045061)4.16323451
25detection of bacterium (GO:0016045)4.14581952
26regulation of B cell differentiation (GO:0045577)4.13399914
27leukocyte aggregation (GO:0070486)4.05018447
28antigen processing and presentation via MHC class Ib (GO:0002475)4.02796502
29T cell selection (GO:0045058)3.98685021
30ribosomal small subunit assembly (GO:0000028)3.90324612
31negative regulation of phagocytosis (GO:0050765)3.89994244
32negative regulation of interleukin-12 production (GO:0032695)3.88964009
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.88056821
34response to peptidoglycan (GO:0032494)3.80782723
35positive T cell selection (GO:0043368)3.74477645
36negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.73445523
37negative regulation of cell killing (GO:0031342)3.73445523
38regulation of interferon-beta biosynthetic process (GO:0045357)3.73440913
39negative regulation of lymphocyte mediated immunity (GO:0002707)3.65322195
40response to interleukin-15 (GO:0070672)3.59257335
41negative regulation of erythrocyte differentiation (GO:0045647)3.47777236
42detection of external biotic stimulus (GO:0098581)3.46913793
43negative regulation of leukocyte mediated immunity (GO:0002704)3.46284885
44regulation of interleukin-12 biosynthetic process (GO:0045075)3.46190668
45antigen receptor-mediated signaling pathway (GO:0050851)3.43410514
46negative regulation of T cell mediated immunity (GO:0002710)3.41707420
47positive regulation of lamellipodium assembly (GO:0010592)3.36417744
48myeloid cell activation involved in immune response (GO:0002275)3.32059741
49response to muramyl dipeptide (GO:0032495)3.31207546
50sequestering of actin monomers (GO:0042989)3.30960264
51T cell receptor signaling pathway (GO:0050852)3.30160632
52regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.29409915
53cellular response to zinc ion (GO:0071294)3.29020454
54response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.26045185
55response to host immune response (GO:0052572)3.26045185
56barbed-end actin filament capping (GO:0051016)3.25461184
57germinal center formation (GO:0002467)3.25049721
58regulation of dendritic cell antigen processing and presentation (GO:0002604)3.25038379
59positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.21213760
60T cell costimulation (GO:0031295)3.19626109
61DNA deamination (GO:0045006)3.18793538
62natural killer cell differentiation (GO:0001779)3.16349338
63T cell migration (GO:0072678)3.16174200
64T cell apoptotic process (GO:0070231)3.15091625
65regulation of mast cell degranulation (GO:0043304)3.14956451
66cellular response to interleukin-15 (GO:0071350)3.14641336
67lymphocyte costimulation (GO:0031294)3.14389942
68respiratory burst (GO:0045730)3.12306336
69neutrophil activation (GO:0042119)3.12126605
70cellular response to virus (GO:0098586)3.10738997
71regulation of antigen processing and presentation (GO:0002577)3.09708168
72modulation by virus of host process (GO:0019054)3.08415068
73negative regulation of innate immune response (GO:0045824)3.08140228
74viral transcription (GO:0019083)3.07866412
75hepatocyte apoptotic process (GO:0097284)3.06381398
76cellular extravasation (GO:0045123)3.06222765
77positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.04229767
78response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.03987384
79response to host (GO:0075136)3.03987384
80response to host defenses (GO:0052200)3.03987384
81NIK/NF-kappaB signaling (GO:0038061)3.03046443
82granulocyte activation (GO:0036230)3.02999433
83interferon-gamma production (GO:0032609)3.02868244
84positive regulation of antigen processing and presentation (GO:0002579)3.01430627
85tolerance induction (GO:0002507)3.00937224
86detection of molecule of bacterial origin (GO:0032490)3.00592584
87lipopolysaccharide-mediated signaling pathway (GO:0031663)3.00421139
88actin nucleation (GO:0045010)3.00287797
89negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.99176997
90regulation of T cell tolerance induction (GO:0002664)2.99049023
91detection of biotic stimulus (GO:0009595)2.98452421
92regulation of myeloid leukocyte mediated immunity (GO:0002886)2.97510363
93regulation of T-helper 2 cell differentiation (GO:0045628)2.96941783
94T cell homeostasis (GO:0043029)2.96513812
95regulation of T cell mediated cytotoxicity (GO:0001914)2.94885923
96regulation of tolerance induction (GO:0002643)2.94730873
97regulation of leukocyte degranulation (GO:0043300)2.93165472
98positive regulation of lamellipodium organization (GO:1902745)2.92464931
99regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.91996190
100regulation of T cell receptor signaling pathway (GO:0050856)2.91137353
101immunoglobulin mediated immune response (GO:0016064)2.90947877
102regulation of alpha-beta T cell proliferation (GO:0046640)2.90087477
103regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.88468020
104regulation of natural killer cell mediated immunity (GO:0002715)2.88468020
105DNA unwinding involved in DNA replication (GO:0006268)2.87828622
106translational termination (GO:0006415)2.86857316
107regulation of type I interferon-mediated signaling pathway (GO:0060338)2.86767766
108regulation of response to interferon-gamma (GO:0060330)2.86654804
109microglial cell activation (GO:0001774)2.86137092
110regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.84418849
111negative regulation of cytokine production involved in immune response (GO:0002719)2.84395507
112regulation of mast cell activation involved in immune response (GO:0033006)2.83441103
113leukocyte degranulation (GO:0043299)2.82320893
114immune response-activating cell surface receptor signaling pathway (GO:0002429)2.81738517
115macrophage activation (GO:0042116)2.81305790
116regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.80852344
117mature B cell differentiation involved in immune response (GO:0002313)2.80089564
118mucosal-associated lymphoid tissue development (GO:0048537)2.79612670
119Peyers patch development (GO:0048541)2.79612670
120lymphocyte apoptotic process (GO:0070227)2.79068674
121negative regulation of type 2 immune response (GO:0002829)2.78960584
122positive regulation of T cell mediated cytotoxicity (GO:0001916)2.76810862
123modulation by symbiont of host cellular process (GO:0044068)2.74295591
124B cell mediated immunity (GO:0019724)2.73487724
125regulation of defense response to virus by virus (GO:0050690)2.73425675
126negative regulation of interleukin-6 production (GO:0032715)2.73141910
127positive regulation of interferon-alpha production (GO:0032727)2.71532985
128positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.70866722
129translational elongation (GO:0006414)2.70721632
130positive regulation of mast cell activation (GO:0033005)2.70406632
131mast cell activation (GO:0045576)2.70000955
132positive regulation of interleukin-2 production (GO:0032743)2.69637964
133regulation of isotype switching to IgG isotypes (GO:0048302)2.68793198
134mature B cell differentiation (GO:0002335)2.67326476
135positive regulation of isotype switching (GO:0045830)2.67192676
136lymphocyte homeostasis (GO:0002260)2.67098455
137positive regulation of alpha-beta T cell proliferation (GO:0046641)2.62236118
138leukocyte cell-cell adhesion (GO:0007159)2.61388863
139DNA strand elongation involved in DNA replication (GO:0006271)2.60320424
140angiogenesis involved in wound healing (GO:0060055)2.59893804
141telomere maintenance via semi-conservative replication (GO:0032201)2.59650400
142JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.57263983
143lymph node development (GO:0048535)2.57168038
144response to type I interferon (GO:0034340)2.55920218
145activation of MAPKKK activity (GO:0000185)2.54239909
146interferon-gamma-mediated signaling pathway (GO:0060333)2.52792164
147defense response to protozoan (GO:0042832)2.52729936
148myeloid dendritic cell activation (GO:0001773)2.52392287
149natural killer cell activation (GO:0030101)2.52079317
150cellular response to type I interferon (GO:0071357)2.51354446
151type I interferon signaling pathway (GO:0060337)2.51354446
152response to protozoan (GO:0001562)2.51249880
153DNA strand elongation (GO:0022616)2.49028839
154negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.47272322
155nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.45130581
156positive regulation of T cell differentiation (GO:0045582)2.41842113
157negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.41668766
158leukocyte homeostasis (GO:0001776)2.41421819

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.96699368
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.71630731
3* MYC_22102868_ChIP-Seq_BL_Human3.69403387
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.43358414
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.27304500
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.22404268
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.98623517
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.98135768
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.80024212
10VDR_21846776_ChIP-Seq_THP-1_Human2.74061322
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.68333343
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.50392868
13MAF_26560356_Chip-Seq_TH1_Human2.34669138
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.31062092
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.26151888
16* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.25648602
17* UTX_26944678_Chip-Seq_JUKART_Human2.18905384
18MYB_26560356_Chip-Seq_TH2_Human2.14226905
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.07547910
20SCL_19346495_ChIP-Seq_HPC-7_Human2.07499591
21* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.03798559
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.02404998
23FOXM1_23109430_ChIP-Seq_U2OS_Human1.98851749
24MYB_21317192_ChIP-Seq_ERMYB_Mouse1.96943435
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.94700672
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.94403787
27ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.93831741
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.93766685
29MYB_26560356_Chip-Seq_TH1_Human1.92510851
30* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.89974014
31TCF7_22412390_ChIP-Seq_EML_Mouse1.87674839
32* SPI1_23547873_ChIP-Seq_NB4_Human1.85458907
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.82704584
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.80475118
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.79690159
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.75518603
37CIITA_25753668_ChIP-Seq_RAJI_Human1.74852928
38VDR_24763502_ChIP-Seq_THP-1_Human1.73475729
39* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.71232829
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.70774392
41* RUNX_20019798_ChIP-Seq_JUKART_Human1.68447619
42MAF_26560356_Chip-Seq_TH2_Human1.67514717
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.66085573
44KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.65767239
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.64979358
46KDM2B_26808549_Chip-Seq_DND41_Human1.64481617
47NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62587694
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.62118844
49* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.61236607
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.60853669
51STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.57228932
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56478421
53SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.50879560
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48776331
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.45481992
56E2F4_17652178_ChIP-ChIP_JURKAT_Human1.44707830
57BCOR_27268052_Chip-Seq_Bcells_Human1.43491943
58IRF8_27001747_Chip-Seq_BMDM_Mouse1.42770694
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.42235117
60* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.40204390
61CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39448560
62GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.38419324
63VDR_23849224_ChIP-Seq_CD4+_Human1.37395569
64XRN2_22483619_ChIP-Seq_HELA_Human1.37089481
65SPI1_23127762_ChIP-Seq_K562_Human1.36970640
66* KDM2B_26808549_Chip-Seq_JURKAT_Human1.36919154
67FOXP3_21729870_ChIP-Seq_TREG_Human1.36341846
68FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.35469784
69P68_20966046_ChIP-Seq_HELA_Human1.35316417
70* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34466785
71* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34226685
72CTCF_27219007_Chip-Seq_ERYTHROID_Human1.33388983
73* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32856967
74MYC_19079543_ChIP-ChIP_MESCs_Mouse1.30875434
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.30867530
76SA1_27219007_Chip-Seq_ERYTHROID_Human1.30764100
77MYC_18358816_ChIP-ChIP_MESCs_Mouse1.28151130
78GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25133473
79* GATA3_27048872_Chip-Seq_THYMUS_Human1.24590535
80STAT6_21828071_ChIP-Seq_BEAS2B_Human1.24467566
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.23518450
82* E2F1_21310950_ChIP-Seq_MCF-7_Human1.21457865
83* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19209444
84RACK7_27058665_Chip-Seq_MCF-7_Human1.18310987
85MYC_19030024_ChIP-ChIP_MESCs_Mouse1.18039469
86HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17272845
87TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15646331
88CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15053341
89RARG_19884340_ChIP-ChIP_MEFs_Mouse1.14928874
90SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14652746
91GABP_19822575_ChIP-Seq_HepG2_Human1.14167686
92KDM2B_26808549_Chip-Seq_K562_Human1.13866007
93LXR_22292898_ChIP-Seq_THP-1_Human1.13518494
94* GATA1_19941826_ChIP-Seq_K562_Human1.13164851
95SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12019051
96ETS1_20019798_ChIP-Seq_JURKAT_Human1.11934519
97HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.11900191
98* TET1_21451524_ChIP-Seq_MESCs_Mouse1.10393132
99LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.09628397
100GABP_17652178_ChIP-ChIP_JURKAT_Human1.09350399
101THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09040761
102VDR_24787735_ChIP-Seq_THP-1_Human1.08868355
103SMC4_20622854_ChIP-Seq_HELA_Human1.07204502
104ELF1_20517297_ChIP-Seq_JURKAT_Human1.07117672
105DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06834673
106PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06771477
107JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.06387396
108TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05930132
109Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.05906636
110* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.05835693
111EST1_17652178_ChIP-ChIP_JURKAT_Human1.04254150
112CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03950037
113* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03162796
114GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02351729
115PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02270172
116CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01121109
117SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01044546
118DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00896130
119* BCL6_27268052_Chip-Seq_Bcells_Human0.99868442
120CTCF_26484167_Chip-Seq_Bcells_Mouse0.98911855
121SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98076345
122TFEB_21752829_ChIP-Seq_HELA_Human0.97905626
123NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.97678095
124CTCF_21964334_ChIP-Seq_BJAB-B_Human0.97573720
125RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96808698
126SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96598978
127SPI1_20517297_ChIP-Seq_HL60_Human0.96185554
128KDM5A_27292631_Chip-Seq_BREAST_Human0.94829587
129CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93516337
130* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.93393954
131RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92981733
132FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.92215895
133GATA1_19941827_ChIP-Seq_MEL_Mouse0.92008558
134FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91886497
135* NCOR1_26117541_ChIP-Seq_K562_Human0.90866415
136* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89979388
137DCP1A_22483619_ChIP-Seq_HELA_Human0.89680553

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology3.87440532
2MP0001835_abnormal_antigen_presentation3.78137936
3MP0000685_abnormal_immune_system3.63943101
4MP0005671_abnormal_response_to3.18282527
5MP0001800_abnormal_humoral_immune3.11775190
6MP0002396_abnormal_hematopoietic_system2.94993901
7MP0002398_abnormal_bone_marrow2.78944403
8MP0005387_immune_system_phenotype2.78450289
9MP0001790_abnormal_immune_system2.78450289
10MP0002452_abnormal_antigen_presenting2.68587269
11MP0009785_altered_susceptibility_to2.64883771
12MP0002420_abnormal_adaptive_immunity2.64878792
13MP0001819_abnormal_immune_cell2.61280554
14MP0005000_abnormal_immune_tolerance2.54166919
15MP0002723_abnormal_immune_serum2.52422490
16MP0009333_abnormal_splenocyte_physiolog2.47855684
17MP0002166_altered_tumor_susceptibility2.44775377
18MP0003436_decreased_susceptibility_to2.44280709
19MP0000716_abnormal_immune_system2.37052298
20MP0000689_abnormal_spleen_morphology2.31523762
21MP0004808_abnormal_hematopoietic_stem2.29026376
22MP0005025_abnormal_response_to2.27040309
23MP0002722_abnormal_immune_system2.25196357
24MP0010352_gastrointestinal_tract_polyps2.24061217
25MP0000703_abnormal_thymus_morphology2.23452151
26MP0002429_abnormal_blood_cell2.09337290
27MP0002405_respiratory_system_inflammati2.07924817
28MP0005464_abnormal_platelet_physiology2.02787590
29MP0003303_peritoneal_inflammation1.99519600
30MP0005397_hematopoietic_system_phenotyp1.95713490
31MP0001545_abnormal_hematopoietic_system1.95713490
32MP0003693_abnormal_embryo_hatching1.93858790
33MP0002419_abnormal_innate_immunity1.89723412
34MP0008260_abnormal_autophagy1.89423736
35MP0010155_abnormal_intestine_physiology1.85912196
36MP0002148_abnormal_hypersensitivity_rea1.85395467
37MP0005451_abnormal_body_composition1.82495679
38MP0002006_tumorigenesis1.81109083
39MP0003300_gastrointestinal_ulcer1.78640974
40MP0001853_heart_inflammation1.65292881
41MP0009278_abnormal_bone_marrow1.64108433
42MP0003075_altered_response_to1.62790803
43MP0004947_skin_inflammation1.61139364
44MP0003866_abnormal_defecation1.59224857
45MP0001873_stomach_inflammation1.55020655
46MP0001845_abnormal_inflammatory_respons1.53772311
47MP0000858_altered_metastatic_potential1.52675025
48MP0002933_joint_inflammation1.52021160
49MP0006054_spinal_hemorrhage1.46585526
50MP0002019_abnormal_tumor_incidence1.45092993
51MP0000490_abnormal_crypts_of1.44560925
52MP0003077_abnormal_cell_cycle1.40634979
53MP0003279_aneurysm1.39356642
54MP0000465_gastrointestinal_hemorrhage1.38066913
55MP0003724_increased_susceptibility_to1.37062619
56MP0010094_abnormal_chromosome_stability1.33792271
57MP0006082_CNS_inflammation1.33512912
58MP0000604_amyloidosis1.32673651
59MP0004957_abnormal_blastocyst_morpholog1.28169346
60MP0008007_abnormal_cellular_replicative1.25838385
61MP0005023_abnormal_wound_healing1.24163706
62MP0004510_myositis1.22015322
63MP0003183_abnormal_peptide_metabolism1.20405807
64MP0003111_abnormal_nucleus_morphology1.20101530
65MP0001533_abnormal_skeleton_physiology1.19641151
66MP0003566_abnormal_cell_adhesion1.18833717
67MP0003828_pulmonary_edema1.17629241
68MP0003806_abnormal_nucleotide_metabolis1.10870844
69MP0004381_abnormal_hair_follicle1.09614084
70MP0003690_abnormal_glial_cell1.09338663
71MP0008469_abnormal_protein_level1.05248991
72MP0003705_abnormal_hypodermis_morpholog0.99493934
73MP0001348_abnormal_lacrimal_gland0.99198003
74MP0001663_abnormal_digestive_system0.99089743
75MP0003329_amyloid_beta_deposits0.98002063
76MP0005076_abnormal_cell_differentiation0.95825670
77MP0000313_abnormal_cell_death0.93837545
78MP0008874_decreased_physiological_sensi0.91150866
79MP0009840_abnormal_foam_cell0.90285394
80MP0004883_abnormal_blood_vessel0.89299940
81MP0000350_abnormal_cell_proliferation0.87622455
82MP0005174_abnormal_tail_pigmentation0.87191741
83MP0003448_altered_tumor_morphology0.85023305
84MP0008058_abnormal_DNA_repair0.82931585
85MP0000343_altered_response_to0.82909435
86MP0005310_abnormal_salivary_gland0.82203960
87MP0003191_abnormal_cellular_cholesterol0.82166457
88MP0004130_abnormal_muscle_cell0.79075194
89MP0000015_abnormal_ear_pigmentation0.78966962
90MP0010307_abnormal_tumor_latency0.77626517
91MP0003045_fibrosis0.75663519
92MP0002132_abnormal_respiratory_system0.73416310
93MP0003172_abnormal_lysosome_physiology0.72907276
94MP0005164_abnormal_response_to0.72852699
95MP0008004_abnormal_stomach_pH0.72550943
96MP0000477_abnormal_intestine_morphology0.70725397
97* MP0001730_embryonic_growth_arrest0.69035793
98MP0002095_abnormal_skin_pigmentation0.69027965
99MP0005058_abnormal_lysosome_morphology0.68608053
100MP0002277_abnormal_respiratory_mucosa0.68497016
101MP0003091_abnormal_cell_migration0.67135551
102MP0009764_decreased_sensitivity_to0.66898232
103MP0004858_abnormal_nervous_system0.66751161
104MP0005075_abnormal_melanosome_morpholog0.64467739
105MP0003656_abnormal_erythrocyte_physiolo0.64303342
106MP0009765_abnormal_xenobiotic_induced0.63489742
107MP0009763_increased_sensitivity_to0.62667406
108MP0000920_abnormal_myelination0.62597730
109MP0000598_abnormal_liver_morphology0.62099424
110MP0004185_abnormal_adipocyte_glucose0.61554297
111MP0003943_abnormal_hepatobiliary_system0.60912225
112MP0005381_digestive/alimentary_phenotyp0.59916315
113* MP0005621_abnormal_cell_physiology0.59671559
114MP0002138_abnormal_hepatobiliary_system0.59361976
115MP0003453_abnormal_keratinocyte_physiol0.59265318
116MP0002332_abnormal_exercise_endurance0.59108922
117* MP0002080_prenatal_lethality0.58919124
118MP0000249_abnormal_blood_vessel0.57766293
119MP0002998_abnormal_bone_remodeling0.56492800
120MP0003879_abnormal_hair_cell0.54962780
121MP0005166_decreased_susceptibility_to0.53323676
122MP0008961_abnormal_basal_metabolism0.53300596
123MP0003795_abnormal_bone_structure0.53088660
124MP0005167_abnormal_blood-brain_barrier0.52445410
125MP0005390_skeleton_phenotype0.51444741
126MP0001542_abnormal_bone_strength0.50238554
127MP0010234_abnormal_vibrissa_follicle0.50051626
128MP0001851_eye_inflammation0.49816680

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bronchitis (HP:0002837)4.81367472
2Abnormality of macrophages (HP:0004311)4.61422352
3Orchitis (HP:0100796)4.33302503
4T lymphocytopenia (HP:0005403)4.20998585
5Elevated erythrocyte sedimentation rate (HP:0003565)4.19662570
6Chronic otitis media (HP:0000389)4.17814496
7Panhypogammaglobulinemia (HP:0003139)4.17299222
8Agammaglobulinemia (HP:0004432)4.14979350
9Abnormality of T cell number (HP:0011839)4.10594249
10IgM deficiency (HP:0002850)3.99463606
11Recurrent viral infections (HP:0004429)3.97397398
12Retrobulbar optic neuritis (HP:0100654)3.96076693
13Optic neuritis (HP:0100653)3.96076693
14Recurrent gram-negative bacterial infections (HP:0005420)3.93063179
15Cellulitis (HP:0100658)3.78865816
16Abnormality of T cells (HP:0002843)3.74422151
17Recurrent fungal infections (HP:0002841)3.58012994
18Abnormality of B cell number (HP:0010975)3.51685993
19B lymphocytopenia (HP:0010976)3.51685993
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.46768982
21Thrombocytosis (HP:0001894)3.46702327
22Gastrointestinal infarctions (HP:0005244)3.44829231
23Papilloma (HP:0012740)3.35531636
24Verrucae (HP:0200043)3.35531636
25Autoimmune thrombocytopenia (HP:0001973)3.21499904
26Abnormality of glycosphingolipid metabolism (HP:0004343)3.20078352
27Abnormality of glycolipid metabolism (HP:0010969)3.20078352
28Abnormality of liposaccharide metabolism (HP:0010968)3.20078352
29Lymphopenia (HP:0001888)3.19330558
30Nasal polyposis (HP:0100582)3.18596606
31Recurrent abscess formation (HP:0002722)3.18341380
32Eczematoid dermatitis (HP:0000976)3.18245461
33Severe combined immunodeficiency (HP:0004430)3.15438806
34Meningitis (HP:0001287)3.14708128
35Abnormality of cells of the lymphoid lineage (HP:0012140)3.14379641
36Combined immunodeficiency (HP:0005387)3.13268737
37Abnormality of the nasal mucosa (HP:0000433)3.10571298
38Spontaneous hematomas (HP:0007420)3.10345700
39Myositis (HP:0100614)3.09372205
40IgG deficiency (HP:0004315)3.06554984
41Gastrointestinal inflammation (HP:0004386)3.06505612
42Thyroiditis (HP:0100646)3.05654298
43Abnormality of T cell physiology (HP:0011840)2.99570462
44Gingivitis (HP:0000230)2.98357674
45Urticaria (HP:0001025)2.94784863
46Keratoconjunctivitis sicca (HP:0001097)2.94176451
47Inflammation of the large intestine (HP:0002037)2.92433504
48Chronic sinusitis (HP:0011109)2.82761585
49Dysostosis multiplex (HP:0000943)2.74712812
50Recurrent cutaneous fungal infections (HP:0011370)2.74534771
51Chronic mucocutaneous candidiasis (HP:0002728)2.74534771
52Recurrent bacterial skin infections (HP:0005406)2.71577322
53Colitis (HP:0002583)2.67195668
54Increased cerebral lipofuscin (HP:0011813)2.67029359
55Gastrointestinal stroma tumor (HP:0100723)2.66898476
56Keratoconjunctivitis (HP:0001096)2.65971249
57Increased density of long bones (HP:0006392)2.62186726
58Pustule (HP:0200039)2.59385939
59Eosinophilia (HP:0001880)2.58653399
60Purpura (HP:0000979)2.58492224
61Emphysema (HP:0002097)2.57522494
62Bronchitis (HP:0012387)2.54275565
63Recurrent sinusitis (HP:0011108)2.51534304
64Vasculitis (HP:0002633)2.51285829
65Gingival bleeding (HP:0000225)2.47895023
66Mediastinal lymphadenopathy (HP:0100721)2.46528222
67Basal cell carcinoma (HP:0002671)2.43671946
68Granulocytopenia (HP:0001913)2.43348810
69Lymphoma (HP:0002665)2.42572163
70Abnormality of the fingertips (HP:0001211)2.38800652
71Hypoplasia of the thymus (HP:0000778)2.38239063
72Recurrent skin infections (HP:0001581)2.38056932
73Leukocytosis (HP:0001974)2.38056886
74Episodic fever (HP:0001954)2.36218736
75Abnormality of eosinophils (HP:0001879)2.35750993
76Systemic lupus erythematosus (HP:0002725)2.35423423
77Hypochromic anemia (HP:0001931)2.32244352
78Loss of speech (HP:0002371)2.31717503
79Petechiae (HP:0000967)2.30215867
80Amyloidosis (HP:0011034)2.28074585
81Hypertensive crisis (HP:0100735)2.27824718
82Increased neuronal autofluorescent lipopigment (HP:0002074)2.27800328
83IgA deficiency (HP:0002720)2.27358358
84Hematochezia (HP:0002573)2.27255992
85Increased serum ferritin (HP:0003281)2.23608596
86Epistaxis (HP:0000421)2.20388104
87Osteomyelitis (HP:0002754)2.20128426
88Viral hepatitis (HP:0006562)2.18780588
89Pulmonary embolism (HP:0002204)2.17591356
90Prolonged bleeding time (HP:0003010)2.15299099
91Peritonitis (HP:0002586)2.13832652
92Slow saccadic eye movements (HP:0000514)2.11647504
93Aplastic anemia (HP:0001915)2.08544010
94Abnormality of polysaccharide metabolism (HP:0011012)2.06222859
95Abnormality of glycosaminoglycan metabolism (HP:0004371)2.06222859
96Abnormality of mucopolysaccharide metabolism (HP:0011020)2.06222859
97Stomatitis (HP:0010280)2.05703133
98Papilledema (HP:0001085)2.04482732
99Hepatosplenomegaly (HP:0001433)2.04363019
100Abnormality of the peritoneum (HP:0002585)2.04070882
101Aortic aneurysm (HP:0004942)2.03483230
102Multiple enchondromatosis (HP:0005701)2.02789002
103Cerebral aneurysm (HP:0004944)2.02731699
104Hypochromic microcytic anemia (HP:0004840)2.01971727
105Protrusio acetabuli (HP:0003179)2.01862560
106Sepsis (HP:0100806)1.99620548
107Vertebral arch anomaly (HP:0008438)1.98846870
108Abnormality of the pleura (HP:0002103)1.97858376
109Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.97399233
110Anorexia (HP:0002039)1.96276508
111Hypergammaglobulinemia (HP:0010702)1.96261318
112Interstitial pulmonary disease (HP:0006530)1.94735700
113Supranuclear gaze palsy (HP:0000605)1.93449524
114Chest pain (HP:0100749)1.91817814
115Acne (HP:0001061)1.91639841
116Polygenic inheritance (HP:0010982)1.91627317
117Abnormality of cells of the erythroid lineage (HP:0012130)1.91403902
118Skin ulcer (HP:0200042)1.91088655
119Mucopolysacchariduria (HP:0008155)1.90688069
120Urinary glycosaminoglycan excretion (HP:0003541)1.90688069
121Autoimmune hemolytic anemia (HP:0001890)1.90637395
122Abnormality of iron homeostasis (HP:0011031)1.90293911
123Recurrent lower respiratory tract infections (HP:0002783)1.89471545
124Increased IgE level (HP:0003212)1.87543803
125Hyperacusis (HP:0010780)1.86337607
126Poikiloderma (HP:0001029)1.85442405
127Restrictive lung disease (HP:0002091)1.84201881
128Encephalitis (HP:0002383)1.83462848
129Recurrent otitis media (HP:0000403)1.82151178
130Abnormal number of erythroid precursors (HP:0012131)1.81005693
131Bicuspid aortic valve (HP:0001647)1.80390337
132Vertebral compression fractures (HP:0002953)1.79000952
133Cutaneous melanoma (HP:0012056)1.78685864
134Dilatation of the ascending aorta (HP:0005111)1.76569940
135Chronic obstructive pulmonary disease (HP:0006510)1.76382069
136Obstructive lung disease (HP:0006536)1.76382069
137Pulmonary infiltrates (HP:0002113)1.75167560
138Arterial thrombosis (HP:0004420)1.75042837
139Subacute progressive viral hepatitis (HP:0006572)1.75002336
140Hemoptysis (HP:0002105)1.74494848
141Increased IgM level (HP:0003496)1.73094774
142Chronic diarrhea (HP:0002028)1.72364308
143Periodontitis (HP:0000704)1.71664802
144Aplasia/Hypoplasia of the thymus (HP:0010515)1.71340257

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.98752072
2PRPF4B3.36313221
3TRIB33.08777683
4MAP3K102.78792531
5PKN22.63735278
6ZAP702.53706425
7EEF2K2.44739622
8ERN12.27671558
9PIM22.22594623
10GRK62.16327718
11JAK32.15522956
12MAP2K32.10468268
13BTK2.05807792
14TXK2.03534770
15RIPK11.94890476
16STK101.91021432
17NME21.90427578
18TBK11.88636772
19TAOK31.80983760
20TYK21.76633277
21KDR1.74340209
22ITK1.72644145
23BLK1.68685803
24LRRK21.67207523
25SYK1.62875452
26FLT31.61553791
27TEC1.60919282
28TAOK11.56294629
29RPS6KA41.54991377
30MAP3K111.52343482
31IKBKE1.51946642
32TESK21.50596743
33ARAF1.49863647
34KIT1.49856777
35SIK31.44626087
36IRAK31.40104791
37CSF1R1.39454430
38EPHB11.34608717
39SCYL21.31178729
40HCK1.31029932
41PIM11.26588753
42MAP3K11.22239283
43LCK1.20564631
44MARK21.13831849
45SMG11.13483872
46SIK11.12771414
47FGFR41.11689226
48FGR1.10608820
49NLK1.07562127
50CSK1.04537650
51KSR21.03041214
52PRKD21.02830233
53IRAK41.00876843
54NEK20.99625253
55MAP3K140.97489897
56IKBKB0.97114668
57MARK30.92407043
58JAK10.91982817
59MAP3K130.91488043
60TGFBR20.86846389
61RAF10.86615362
62FES0.86193813
63LYN0.84726056
64CDC42BPA0.80940304
65MAPK120.80795807
66TAOK20.76569936
67FGFR30.76036626
68CDK40.76026644
69NEK90.75981261
70TESK10.75899840
71CLK10.74874014
72PDPK10.74564896
73PRKCH0.73328901
74MAP3K80.73113498
75EIF2AK10.72705268
76IRAK20.72171654
77DAPK20.71305484
78SIK20.69908808
79TNK20.68433144
80CDK190.65682661
81PAK60.65679789
82TGFBR10.65554641
83CDC70.64217802
84MAP3K30.63698480
85RPS6KB20.62325578
86PTK60.60548194
87TTN0.57685963
88GRK70.55890835
89ILK0.54827768
90FYN0.54566308
91PAK40.53489855
92MAP2K20.52087266
93MOS0.51922907
94BUB10.51891315
95MAPK70.51185097
96MAP3K120.50430882
97STK40.50219321
98DYRK1B0.49267999
99PRKCQ0.47884017
100CAMKK20.47536813
101STK380.47476109
102MAPK110.47401714
103RPS6KL10.47243011
104RPS6KC10.47243011
105ICK0.47031073
106JAK20.46932603
107CAMKK10.46155583
108CHUK0.45680822
109PASK0.45664386
110STK240.44281412
111RIPK40.43037525
112MAPK40.42454717
113BMPR20.42219763
114BMX0.42095323
115MAPKAPK30.41664976
116ALK0.41059842
117RPS6KA60.40596238
118EIF2AK30.40123411
119MAP2K60.38898949
120MATK0.37872268
121TLK10.37655940
122IRAK10.37634125
123MAPKAPK20.37482988
124WEE10.37478131
125DAPK10.36909148
126PIK3CG0.36705513
127BRAF0.35340914
128HIPK20.34287700
129BRSK10.33802787
130ATR0.33624190
131PDK10.33558719
132MAP3K50.32569620
133MAP3K70.32418889
134CDK120.32233295

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.41123218
2DNA replication_Homo sapiens_hsa030302.72540789
3B cell receptor signaling pathway_Homo sapiens_hsa046622.57556848
4Autoimmune thyroid disease_Homo sapiens_hsa053202.38556326
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.10336852
6Base excision repair_Homo sapiens_hsa034102.07420657
7T cell receptor signaling pathway_Homo sapiens_hsa046602.05038872
8Leishmaniasis_Homo sapiens_hsa051401.99479982
9Mismatch repair_Homo sapiens_hsa034301.95585780
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.94620673
11Measles_Homo sapiens_hsa051621.93473281
12Antigen processing and presentation_Homo sapiens_hsa046121.92346641
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.84321950
14Type I diabetes mellitus_Homo sapiens_hsa049401.78935820
15Ribosome_Homo sapiens_hsa030101.75276037
16Shigellosis_Homo sapiens_hsa051311.72326263
17Asthma_Homo sapiens_hsa053101.69732170
18Osteoclast differentiation_Homo sapiens_hsa043801.68022759
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.62660384
20Chronic myeloid leukemia_Homo sapiens_hsa052201.60085176
21Hematopoietic cell lineage_Homo sapiens_hsa046401.59907157
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.54925159
23Herpes simplex infection_Homo sapiens_hsa051681.53438823
24Acute myeloid leukemia_Homo sapiens_hsa052211.53142960
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.49192867
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.47590206
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42629039
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.39392885
29Viral myocarditis_Homo sapiens_hsa054161.37429968
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.36175525
31Apoptosis_Homo sapiens_hsa042101.35783595
32Hepatitis B_Homo sapiens_hsa051611.34480195
33Toxoplasmosis_Homo sapiens_hsa051451.32265409
34Spliceosome_Homo sapiens_hsa030401.29925089
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.27083953
36Pancreatic cancer_Homo sapiens_hsa052121.24453055
37Chemokine signaling pathway_Homo sapiens_hsa040621.22365443
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.21855728
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.21236644
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.20866023
41Epstein-Barr virus infection_Homo sapiens_hsa051691.19504285
42Rheumatoid arthritis_Homo sapiens_hsa053231.18588910
43Neurotrophin signaling pathway_Homo sapiens_hsa047221.17342476
44Phagosome_Homo sapiens_hsa041451.17046492
45HTLV-I infection_Homo sapiens_hsa051661.16561842
46Lysosome_Homo sapiens_hsa041421.16026027
47Influenza A_Homo sapiens_hsa051641.15292875
48Nucleotide excision repair_Homo sapiens_hsa034201.14660070
49Allograft rejection_Homo sapiens_hsa053301.14486443
50Platelet activation_Homo sapiens_hsa046111.13190679
51Non-small cell lung cancer_Homo sapiens_hsa052231.12172297
52African trypanosomiasis_Homo sapiens_hsa051431.12017645
53Colorectal cancer_Homo sapiens_hsa052101.12011458
54p53 signaling pathway_Homo sapiens_hsa041151.07702777
55Viral carcinogenesis_Homo sapiens_hsa052031.05937245
56Cell cycle_Homo sapiens_hsa041101.05842010
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03911966
58VEGF signaling pathway_Homo sapiens_hsa043701.03629007
59Homologous recombination_Homo sapiens_hsa034401.03176043
60Glycosaminoglycan degradation_Homo sapiens_hsa005311.02456083
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00716754
62TNF signaling pathway_Homo sapiens_hsa046681.00476063
63Non-homologous end-joining_Homo sapiens_hsa034500.99680318
64Legionellosis_Homo sapiens_hsa051340.98594628
65Proteasome_Homo sapiens_hsa030500.95612323
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.94467154
67Tuberculosis_Homo sapiens_hsa051520.93397711
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91694879
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87878838
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85478814
71RNA transport_Homo sapiens_hsa030130.84785431
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83260771
73Salmonella infection_Homo sapiens_hsa051320.83200191
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.82752916
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.82580036
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82502585
77Pertussis_Homo sapiens_hsa051330.81938986
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81580194
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.80605046
80Thyroid cancer_Homo sapiens_hsa052160.80335704
81Hepatitis C_Homo sapiens_hsa051600.80155716
82Small cell lung cancer_Homo sapiens_hsa052220.79026862
83Pyrimidine metabolism_Homo sapiens_hsa002400.78271291
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.77644021
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76500353
86Endometrial cancer_Homo sapiens_hsa052130.71989419
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.70094512
88RNA degradation_Homo sapiens_hsa030180.69556493
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64224845
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63358890
91Prolactin signaling pathway_Homo sapiens_hsa049170.62425939
92GnRH signaling pathway_Homo sapiens_hsa049120.61587911
93RNA polymerase_Homo sapiens_hsa030200.60727379
94Renal cell carcinoma_Homo sapiens_hsa052110.58843172
95Prion diseases_Homo sapiens_hsa050200.57529240
96One carbon pool by folate_Homo sapiens_hsa006700.54762861
97Malaria_Homo sapiens_hsa051440.54171843
98N-Glycan biosynthesis_Homo sapiens_hsa005100.53508192
99Graft-versus-host disease_Homo sapiens_hsa053320.53406908
100mTOR signaling pathway_Homo sapiens_hsa041500.52772028
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52601206
102MAPK signaling pathway_Homo sapiens_hsa040100.52126699
103Endocytosis_Homo sapiens_hsa041440.51001466
104Pentose phosphate pathway_Homo sapiens_hsa000300.50842853
105Amoebiasis_Homo sapiens_hsa051460.50262902
106Inositol phosphate metabolism_Homo sapiens_hsa005620.50004579
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49330303
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49076791
109HIF-1 signaling pathway_Homo sapiens_hsa040660.48713405
110FoxO signaling pathway_Homo sapiens_hsa040680.48576395
111Systemic lupus erythematosus_Homo sapiens_hsa053220.48285684
112Choline metabolism in cancer_Homo sapiens_hsa052310.47975740
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46477464
114mRNA surveillance pathway_Homo sapiens_hsa030150.45464148
115Sulfur relay system_Homo sapiens_hsa041220.45204842
116Glioma_Homo sapiens_hsa052140.44709141
117ErbB signaling pathway_Homo sapiens_hsa040120.43467899
118Bladder cancer_Homo sapiens_hsa052190.42750589
119Pathways in cancer_Homo sapiens_hsa052000.42684532
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42629759
121Other glycan degradation_Homo sapiens_hsa005110.41708726
122Long-term potentiation_Homo sapiens_hsa047200.41348545
123MicroRNAs in cancer_Homo sapiens_hsa052060.40647639
124Insulin resistance_Homo sapiens_hsa049310.39336147
125Staphylococcus aureus infection_Homo sapiens_hsa051500.38851570
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38442414
127Notch signaling pathway_Homo sapiens_hsa043300.38429651
128Proteoglycans in cancer_Homo sapiens_hsa052050.38219435
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38098565
130Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37521091
131Rap1 signaling pathway_Homo sapiens_hsa040150.37025708
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36937287
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.33152081
134Synaptic vesicle cycle_Homo sapiens_hsa047210.30125516
135Type II diabetes mellitus_Homo sapiens_hsa049300.28981610

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