CCNA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm-egg recognition (GO:0035036)9.33879758
2acrosome assembly (GO:0001675)9.21490783
3acrosome reaction (GO:0007340)9.04040070
4binding of sperm to zona pellucida (GO:0007339)8.77792839
5multicellular organism reproduction (GO:0032504)8.50394579
6spermatid development (GO:0007286)8.49775122
7piRNA metabolic process (GO:0034587)8.42610259
8cell-cell recognition (GO:0009988)8.30153823
9cell wall macromolecule metabolic process (GO:0044036)8.01580121
10cell wall macromolecule catabolic process (GO:0016998)8.01580121
11plasma membrane fusion (GO:0045026)7.92632585
12regulation of cilium movement (GO:0003352)7.82936294
13male meiosis (GO:0007140)7.58868732
14centriole assembly (GO:0098534)7.30635522
15reproduction (GO:0000003)7.01232605
16axoneme assembly (GO:0035082)6.98671481
17synaptonemal complex organization (GO:0070193)6.88016564
18hemidesmosome assembly (GO:0031581)6.49072268
19synaptonemal complex assembly (GO:0007130)6.35533350
20single fertilization (GO:0007338)6.32181528
21ventricular system development (GO:0021591)5.96811269
22negative regulation of inclusion body assembly (GO:0090084)5.89283380
23sperm capacitation (GO:0048240)5.75941683
24* spermatogenesis (GO:0007283)5.61117451
25fertilization (GO:0009566)5.60528523
26* male gamete generation (GO:0048232)5.59099114
27intraciliary transport (GO:0042073)5.35876944
28DNA methylation involved in gamete generation (GO:0043046)5.24144774
29* gamete generation (GO:0007276)5.16006161
30nucleoside diphosphate phosphorylation (GO:0006165)5.03461479
31* male meiosis I (GO:0007141)4.87477564
32seminiferous tubule development (GO:0072520)4.80786346
33regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.79833071
34meiotic cell cycle (GO:0051321)4.78702000
35regulation of inclusion body assembly (GO:0090083)4.78370088
36organic cation transport (GO:0015695)4.75795955
37germ cell development (GO:0007281)4.75731068
38left/right pattern formation (GO:0060972)4.72462926
39centriole replication (GO:0007099)4.70848797
40cilium organization (GO:0044782)4.70778328
41GTP biosynthetic process (GO:0006183)4.70247152
42regulation of microtubule-based movement (GO:0060632)4.69758313
43cellular process involved in reproduction in multicellular organism (GO:0022412)4.59991726
44chromosome organization involved in meiosis (GO:0070192)4.59970904
45cilium assembly (GO:0042384)4.46901692
46regulation of vitamin D biosynthetic process (GO:0060556)4.46594025
47microtubule severing (GO:0051013)4.46275201
48microtubule depolymerization (GO:0007019)4.43654681
49protein refolding (GO:0042026)4.38970259
50protein localization to cilium (GO:0061512)4.36023533
51microtubule-based movement (GO:0007018)4.21513201
52UTP biosynthetic process (GO:0006228)4.21101713
53* meiotic nuclear division (GO:0007126)4.11785242
54cell recognition (GO:0008037)4.10022928
55natural killer cell mediated cytotoxicity (GO:0042267)4.08009469
56natural killer cell mediated immunity (GO:0002228)4.08009469
57* multicellular organismal reproductive process (GO:0048609)4.02499691
58protein polyglutamylation (GO:0018095)4.01096124
59cellular component assembly involved in morphogenesis (GO:0010927)4.00006988
60calcium ion-dependent exocytosis (GO:0017156)3.98401454
61leukocyte aggregation (GO:0070486)3.98330358
62* meiosis I (GO:0007127)3.97621368
63UTP metabolic process (GO:0046051)3.83163708
64cilium morphogenesis (GO:0060271)3.75798172
65regulation of collateral sprouting (GO:0048670)3.61241645
66spermatid nucleus differentiation (GO:0007289)3.57416004
67neuroblast proliferation (GO:0007405)3.54087619
68chaperone-mediated protein complex assembly (GO:0051131)3.51068377
69regulation of centriole replication (GO:0046599)3.49054671
70DNA strand renaturation (GO:0000733)3.47394645
71chromosome condensation (GO:0030261)3.37059471
72microtubule bundle formation (GO:0001578)3.36706554
73left/right axis specification (GO:0070986)3.35822620
74intermediate filament organization (GO:0045109)3.32821018
75glycerol ether metabolic process (GO:0006662)3.32717053
76mitotic nuclear envelope reassembly (GO:0007084)3.32652889
77nuclear envelope reassembly (GO:0031468)3.32652889
78genitalia morphogenesis (GO:0035112)3.31814971
79CTP biosynthetic process (GO:0006241)3.31319685
80CTP metabolic process (GO:0046036)3.31319685
81guanosine-containing compound biosynthetic process (GO:1901070)3.26364202
82DNA packaging (GO:0006323)3.26182726
83regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.20237816
84mitochondrion degradation (GO:0000422)3.19732389
85negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.17503911
86regulation of vitamin metabolic process (GO:0030656)3.15716342
87regulation of monocyte differentiation (GO:0045655)3.14516548
88multicellular organismal development (GO:0007275)3.12399636
89mitotic metaphase plate congression (GO:0007080)3.07009057
90gene silencing by RNA (GO:0031047)3.06541606
91ether metabolic process (GO:0018904)3.05935592
92negative regulation of granulocyte differentiation (GO:0030853)3.04965115
93pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.04541527
94axon extension involved in axon guidance (GO:0048846)3.03304654
95neuron projection extension involved in neuron projection guidance (GO:1902284)3.03304654
96regulation of histone phosphorylation (GO:0033127)3.02719521
97negative regulation of DNA-templated transcription, elongation (GO:0032785)3.01000297
98polyamine biosynthetic process (GO:0006596)2.99692086
99negative regulation of organelle assembly (GO:1902116)2.96372724
100synapsis (GO:0007129)2.93819395
101cell projection assembly (GO:0030031)2.92688225
102determination of left/right symmetry (GO:0007368)2.91312660
103regulation of spindle organization (GO:0090224)2.86578209
104pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.83373035
105determination of bilateral symmetry (GO:0009855)2.82693562
106regulation of hair follicle development (GO:0051797)2.81892870
107* meiotic cell cycle process (GO:1903046)2.80669570
108negative regulation of catenin import into nucleus (GO:0035414)2.79839514
109negative regulation of microtubule depolymerization (GO:0007026)2.78617023
110autophagic vacuole assembly (GO:0000045)2.77822149
111specification of symmetry (GO:0009799)2.77509359
112deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.75517532
113regulation of G0 to G1 transition (GO:0070316)2.74816108
114regulation of microtubule depolymerization (GO:0031114)2.74674582
115nucleotide phosphorylation (GO:0046939)2.71213733
116organelle assembly (GO:0070925)2.70058998
117microtubule polymerization or depolymerization (GO:0031109)2.68445243
118leukocyte mediated cytotoxicity (GO:0001909)2.67692856
119mitotic sister chromatid cohesion (GO:0007064)2.67420899
120protein kinase C signaling (GO:0070528)2.66262277
121pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.65690358
122peptidyl-glutamic acid modification (GO:0018200)2.63800356
123microtubule-based process (GO:0007017)2.62390644
124regulation of mitotic spindle organization (GO:0060236)2.60835041
125protein K11-linked deubiquitination (GO:0035871)2.59567214
126cellular biogenic amine biosynthetic process (GO:0042401)2.59253219
127thalamus development (GO:0021794)2.59027063
128establishment of protein localization to mitochondrial membrane (GO:0090151)2.56940014
129metaphase plate congression (GO:0051310)2.55965698
130sequestering of actin monomers (GO:0042989)2.55087588
131proteasome assembly (GO:0043248)2.54464176
132regulation of female gonad development (GO:2000194)2.53822655
133amino-acid betaine transport (GO:0015838)2.53476915
134carnitine transport (GO:0015879)2.53476915
135positive regulation of chemokine biosynthetic process (GO:0045080)2.51917931
136positive regulation of antigen processing and presentation (GO:0002579)2.51860678
137dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.51759637
138regulation of mononuclear cell migration (GO:0071675)2.51210241
139renal system development (GO:0072001)2.50160486
140DNA topological change (GO:0006265)2.49751609
141regulation of podosome assembly (GO:0071801)2.47884536
142negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.46943025
143sodium ion export (GO:0071436)2.41073311
144negative regulation of epidermis development (GO:0045683)2.37959505
145positive regulation of hair follicle development (GO:0051798)2.37519129
146positive regulation of hair cycle (GO:0042635)2.37519129
147regulation of alkaline phosphatase activity (GO:0010692)2.36885131
148regulation of protein heterodimerization activity (GO:0043497)2.33965918
149artery development (GO:0060840)2.33677142
150branching involved in labyrinthine layer morphogenesis (GO:0060670)2.33643463
151response to acidic pH (GO:0010447)2.33347758
152response to vitamin D (GO:0033280)2.32839752
153regulation of chemokine biosynthetic process (GO:0045073)2.32603919
154amine biosynthetic process (GO:0009309)2.31927448
155cellular response to nicotine (GO:0071316)2.30449487
156membrane protein intracellular domain proteolysis (GO:0031293)2.29414625
157regulation of hypersensitivity (GO:0002883)2.28427771
158semaphorin-plexin signaling pathway (GO:0071526)2.26739043
159midbrain development (GO:0030901)2.25416307
160negative regulation of retinoic acid receptor signaling pathway (GO:0048387)19.9453624
161regulation of retinoic acid receptor signaling pathway (GO:0048385)16.4942473
162axonemal dynein complex assembly (GO:0070286)15.4146404
163cilium or flagellum-dependent cell motility (GO:0001539)14.7455048
164motile cilium assembly (GO:0044458)13.4389723
165cilium movement (GO:0003341)12.4135626
166epithelial cilium movement (GO:0003351)12.3899319
167epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)11.4583342
168sperm motility (GO:0030317)10.9491350
169fusion of sperm to egg plasma membrane (GO:0007342)10.4431250

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.13681445
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.04364160
3EZH2_22144423_ChIP-Seq_EOC_Human4.98429883
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.32152701
5GATA1_26923725_Chip-Seq_HPCs_Mouse2.97073828
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.68708571
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.54942980
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.54942980
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.54942980
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.50756751
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.46810254
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.43426000
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.43293530
14ZNF274_21170338_ChIP-Seq_K562_Hela2.21196590
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.12490148
16EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.11370319
17* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.06963321
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.3632814
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.99799570
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.97422719
21ELK4_26923725_Chip-Seq_MESODERM_Mouse1.95824405
22STAT6_21828071_ChIP-Seq_BEAS2B_Human1.95324190
23GABP_17652178_ChIP-ChIP_JURKAT_Human1.89189280
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.87747069
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.87461387
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77853654
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76981365
28KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.74602838
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71430640
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.69231033
31TP53_20018659_ChIP-ChIP_R1E_Mouse1.69210207
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67544672
33VDR_22108803_ChIP-Seq_LS180_Human1.63832996
34SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.63405610
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63147839
36TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.61709364
37ETV1_20927104_ChIP-Seq_GIST48_Human1.61302721
38BP1_19119308_ChIP-ChIP_Hs578T_Human1.61131500
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57205125
40CBP_20019798_ChIP-Seq_JUKART_Human1.54122270
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54122270
42MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.52065140
43WDR5_24793694_ChIP-Seq_LNCAP_Human1.50894018
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50876623
45TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45405075
46POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45405075
47TAL1_26923725_Chip-Seq_HPCs_Mouse1.45178590
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44864376
49RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.44611857
50RBPJ_21746931_ChIP-Seq_IB4_Human1.43139429
51* REST_21632747_ChIP-Seq_MESCs_Mouse1.41671501
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.41062200
53GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.40037843
54STAT1_17558387_ChIP-Seq_HELA_Human1.38443977
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.37840054
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34136776
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.33548995
58SOX2_22085726_ChIP-Seq_NPCs_Mouse1.32811789
59KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.32442018
60KAP1_22055183_ChIP-Seq_ESCs_Mouse1.31436579
61FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31401927
62FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31144412
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.28820091
64TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28051291
65ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.27868947
66E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.27849188
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27685893
68GATA3_21867929_ChIP-Seq_CD8_Mouse1.26943571
69* PHF8_20622853_ChIP-Seq_HELA_Human1.26910715
70* RNF2_27304074_Chip-Seq_NSC_Mouse1.26442775
71EED_16625203_ChIP-ChIP_MESCs_Mouse1.26086381
72EZH2_27304074_Chip-Seq_ESCs_Mouse1.25786974
73FLI1_21867929_ChIP-Seq_TH2_Mouse1.23912328
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23310092
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.22844030
76LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.21957483
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.21579305
78CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.21106383
79SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.21005908
80CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18156831
81SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.16369193
82ERG_20517297_ChIP-Seq_VCAP_Human1.15262756
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15236391
84GATA6_21074721_ChIP-Seq_CACO-2_Human1.15177573
85CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15152502
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14891164
87SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.14808058
88RUNX1_26923725_Chip-Seq_HPCs_Mouse1.14167631
89ETS1_20019798_ChIP-Seq_JURKAT_Human1.13470082
90GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.13367104
91CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12319681
92REST_18959480_ChIP-ChIP_MESCs_Mouse1.11435241
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10165328
94FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09649629
95GF1_26923725_Chip-Seq_HPCs_Mouse1.09430468
96SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09200204
97PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08618182
98KDM2B_26808549_Chip-Seq_REH_Human1.08483314
99NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08295937
100* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07820260
101SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.06524442
102ZNF263_19887448_ChIP-Seq_K562_Human1.04741128
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.04551024
104P53_21459846_ChIP-Seq_SAOS-2_Human1.03868672
105PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02192401
106* SMAD4_21799915_ChIP-Seq_A2780_Human1.01867670
107RAD21_21589869_ChIP-Seq_MESCs_Mouse1.01513343
108PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01381764
109CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.01261143
110RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00182966
111CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99471991
112EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99267017
113GF1B_26923725_Chip-Seq_HPCs_Mouse0.99008633
114TAF15_26573619_Chip-Seq_HEK293_Human0.98115331
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97801293
116ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97224985
117CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95935350
118SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95417755
119BCAT_22108803_ChIP-Seq_LS180_Human0.94876458
120EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.94870732
121SCL_19346495_ChIP-Seq_HPC-7_Human0.94568382
122XRN2_22483619_ChIP-Seq_HELA_Human0.93153145
123NOTCH1_21737748_ChIP-Seq_TLL_Human0.93088811
124NFYB_21822215_ChIP-Seq_K562_Human0.93032340
125VDR_21846776_ChIP-Seq_THP-1_Human0.92617032
126SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.92264658
127* TCF4_23295773_ChIP-Seq_U87_Human0.92085720
128SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92032143
129JARID2_20075857_ChIP-Seq_MESCs_Mouse0.91925186
130P53_22387025_ChIP-Seq_ESCs_Mouse0.91923911
131GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91819413
132ELF1_20517297_ChIP-Seq_JURKAT_Human0.91258521
133CRX_20693478_ChIP-Seq_RETINA_Mouse0.90405035
134OCT4_18555785_Chip-Seq_ESCs_Mouse0.90374513
135GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.89780601
136SOX2_16153702_ChIP-ChIP_HESCs_Human0.89601791
137SMAD3_21741376_ChIP-Seq_ESCs_Human0.89228594
138POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89195305
139CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88865863
140ELK1_22589737_ChIP-Seq_MCF10A_Human0.88839226
141HNFA_21074721_ChIP-Seq_CACO-2_Human0.88093053
142GATA3_21867929_ChIP-Seq_TH1_Mouse0.88084992
143CTCF_20526341_ChIP-Seq_ESCs_Human0.87944635
144UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.87807958
145EZH2_27294783_Chip-Seq_ESCs_Mouse0.87587815
146TBL1_22424771_ChIP-Seq_293T_Human0.87146709
147NELFA_20434984_ChIP-Seq_ESCs_Mouse0.86890751
148MYC_27129775_Chip-Seq_CORNEA_Mouse0.86317271
149MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.86138158
150ER_23166858_ChIP-Seq_MCF-7_Human0.85882755
151JARID2_20064375_ChIP-Seq_MESCs_Mouse0.85716429
152UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85495699
153BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.84676611
154ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.84546405
155KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.83442029
156OCT4_21477851_ChIP-Seq_ESCs_Mouse0.83314796
157EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.82071019
158YY1_21170310_ChIP-Seq_MESCs_Mouse0.81726174
159P300_18555785_Chip-Seq_ESCs_Mouse0.81561676
160OCT1_27270436_Chip-Seq_PROSTATE_Human0.81483839
161SOX9_26525672_Chip-Seq_HEART_Mouse0.81341546
162TCF4_22108803_ChIP-Seq_LS180_Human0.80899906
163EZH2_27294783_Chip-Seq_NPCs_Mouse0.80470070
164PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.79665432
165FOXA1_25329375_ChIP-Seq_VCAP_Human0.79498381
166FOXA1_27270436_Chip-Seq_PROSTATE_Human0.79498381
167LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78869033
168THAP11_20581084_ChIP-Seq_MESCs_Mouse0.78747339
169TP63_22573176_ChIP-Seq_HFKS_Human0.77462658
170EST1_17652178_ChIP-ChIP_JURKAT_Human0.76792326
171NFYA_21822215_ChIP-Seq_K562_Human0.76419631
172GABP_19822575_ChIP-Seq_HepG2_Human0.74768736
173IRF8_21731497_ChIP-ChIP_J774_Mouse0.74409312
174RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.74152718
175HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.73679466
176CBX2_22325352_ChIP-Seq_293T-Rex_Human0.73254909

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive5.74524978
2* MP0001929_abnormal_gametogenesis5.32178367
3MP0000579_abnormal_nail_morphology4.98688557
4MP0008877_abnormal_DNA_methylation4.39989777
5MP0002653_abnormal_ependyma_morphology4.04742933
6MP0008260_abnormal_autophagy3.80799534
7MP0002102_abnormal_ear_morphology3.51741529
8* MP0002210_abnormal_sex_determination3.36365436
9* MP0002161_abnormal_fertility/fecundity3.08948515
10MP0009379_abnormal_foot_pigmentation2.85089857
11MP0005451_abnormal_body_composition2.79999848
12* MP0001145_abnormal_male_reproductive2.79997046
13MP0005423_abnormal_somatic_nervous2.62696504
14MP0003136_yellow_coat_color2.60748811
15MP0005623_abnormal_meninges_morphology2.54876136
16MP0005499_abnormal_olfactory_system2.50835195
17MP0005394_taste/olfaction_phenotype2.50835195
18MP0002160_abnormal_reproductive_system2.50669674
19* MP0000653_abnormal_sex_gland2.43998533
20MP0002234_abnormal_pharynx_morphology2.33508693
21MP0006276_abnormal_autonomic_nervous2.31125068
22MP0008789_abnormal_olfactory_epithelium2.29296221
23MP0008057_abnormal_DNA_replication2.27289828
24MP0003303_peritoneal_inflammation2.17841502
25MP0000383_abnormal_hair_follicle2.14357511
26MP0006292_abnormal_olfactory_placode2.14280231
27MP0003718_maternal_effect2.05923236
28MP0005410_abnormal_fertilization14.2494463
29MP0004742_abnormal_vestibular_system1.86101701
30MP0005670_abnormal_white_adipose1.84008172
31MP0001984_abnormal_olfaction1.81101333
32MP0000566_synostosis1.79943791
33MP0002282_abnormal_trachea_morphology1.76456346
34MP0003283_abnormal_digestive_organ1.76004889
35MP0003646_muscle_fatigue1.73734802
36MP0005058_abnormal_lysosome_morphology1.70262156
37MP0003453_abnormal_keratinocyte_physiol1.66618878
38MP0003878_abnormal_ear_physiology1.61657330
39MP0005377_hearing/vestibular/ear_phenot1.61657330
40MP0010678_abnormal_skin_adnexa1.61404507
41MP0003693_abnormal_embryo_hatching1.61180315
42MP0000678_abnormal_parathyroid_gland1.52939295
43MP0004019_abnormal_vitamin_homeostasis1.50763494
44MP0002332_abnormal_exercise_endurance1.45667097
45MP0001486_abnormal_startle_reflex1.45199474
46MP0005389_reproductive_system_phenotype1.43056819
47MP0009053_abnormal_anal_canal1.41161166
48MP0003329_amyloid_beta_deposits1.40859154
49MP0001440_abnormal_grooming_behavior1.37661048
50MP0000762_abnormal_tongue_morphology1.36330425
51MP0009840_abnormal_foam_cell1.34515677
52MP0009046_muscle_twitch1.28202958
53MP0002098_abnormal_vibrissa_morphology1.27045961
54MP0003115_abnormal_respiratory_system1.22535826
55MP0003941_abnormal_skin_development1.20376473
56MP0009764_decreased_sensitivity_to1.20077597
57MP0001765_abnormal_ion_homeostasis1.18873494
58MP0000604_amyloidosis1.16364068
59MP0002796_impaired_skin_barrier1.11040364
60MP0001216_abnormal_epidermal_layer1.07330584
61MP0001501_abnormal_sleep_pattern1.06391244
62MP0001727_abnormal_embryo_implantation1.05609740
63MP0004233_abnormal_muscle_weight1.05225719
64MP0003315_abnormal_perineum_morphology1.03710251
65MP0001835_abnormal_antigen_presentation1.03324961
66MP0004782_abnormal_surfactant_physiolog1.03059782
67MP0002277_abnormal_respiratory_mucosa1.01911667
68MP0008058_abnormal_DNA_repair1.01095025
69MP0001177_atelectasis1.00406116
70MP0004510_myositis0.99931367
71MP0005360_urolithiasis0.99795061
72MP0001986_abnormal_taste_sensitivity0.99734807
73MP0002735_abnormal_chemical_nociception0.99164086
74MP0004133_heterotaxia0.98650011
75MP0000750_abnormal_muscle_regeneration0.97444322
76MP0001529_abnormal_vocalization0.97083309
77MP0002148_abnormal_hypersensitivity_rea0.94868039
78MP0001293_anophthalmia0.93807650
79MP0002928_abnormal_bile_duct0.92652320
80MP0000026_abnormal_inner_ear0.92247047
81MP0006082_CNS_inflammation0.90698755
82MP0010030_abnormal_orbit_morphology0.89883342
83MP0000343_altered_response_to0.85618004
84MP0009765_abnormal_xenobiotic_induced0.80724820
85MP0004270_analgesia0.80630355
86MP0001485_abnormal_pinna_reflex0.79347509
87MP0010094_abnormal_chromosome_stability0.78065706
88MP0002067_abnormal_sensory_capabilities0.76956824
89MP0004859_abnormal_synaptic_plasticity0.76832758
90MP0005197_abnormal_uvea_morphology0.76421851
91MP0002882_abnormal_neuron_morphology0.75685241
92MP0003075_altered_response_to0.74873415
93MP0009745_abnormal_behavioral_response0.74199457
94MP0001905_abnormal_dopamine_level0.73582166
95MP0009785_altered_susceptibility_to0.73362892
96MP0003121_genomic_imprinting0.72954813
97MP0008932_abnormal_embryonic_tissue0.72520906
98MP0003890_abnormal_embryonic-extraembry0.66582262
99MP0003950_abnormal_plasma_membrane0.66377909
100MP0004142_abnormal_muscle_tone0.66130742
101MP0000955_abnormal_spinal_cord0.65792340
102MP0000534_abnormal_ureter_morphology0.64358380
103MP0005647_abnormal_sex_gland0.64097214
104MP0010307_abnormal_tumor_latency0.62186174
105MP0002557_abnormal_social/conspecific_i0.61214837
106MP0001324_abnormal_eye_pigmentation0.59229875
107MP0003861_abnormal_nervous_system0.58228057
108MP0002133_abnormal_respiratory_system0.57222467
109MP0005388_respiratory_system_phenotype0.57222467
110MP0005253_abnormal_eye_physiology0.56928929
111MP0000358_abnormal_cell_content/0.56669134
112MP0005501_abnormal_skin_physiology0.54418829
113MP0003011_delayed_dark_adaptation0.53897203
114MP0005391_vision/eye_phenotype0.53613632
115MP0003880_abnormal_central_pattern0.52974979
116MP0005636_abnormal_mineral_homeostasis0.51909965
117MP0005551_abnormal_eye_electrophysiolog0.51564969
118MP0008007_abnormal_cellular_replicative0.50668122
119MP0003942_abnormal_urinary_system0.50149746
120MP0002938_white_spotting0.47890010
121MP0002152_abnormal_brain_morphology0.47521842
122MP0004134_abnormal_chest_morphology0.47022605
123MP0008995_early_reproductive_senescence0.46363304
124MP0005666_abnormal_adipose_tissue0.44757434
125MP0003787_abnormal_imprinting0.43755262
126MP0000537_abnormal_urethra_morphology0.43005576
127MP0003699_abnormal_female_reproductive0.41998392
128MP0002092_abnormal_eye_morphology0.41377220
129MP0004197_abnormal_fetal_growth/weight/0.41154414
130MP0005195_abnormal_posterior_eye0.40311372
131MP0000778_abnormal_nervous_system0.38520775
132MP0008569_lethality_at_weaning0.38406479
133MP0000427_abnormal_hair_cycle0.38140048
134MP0003879_abnormal_hair_cell0.38001094
135MP0004264_abnormal_extraembryonic_tissu0.37958328
136MP0006138_congestive_heart_failure0.37734787
137MP0001849_ear_inflammation0.37334014
138MP0001340_abnormal_eyelid_morphology0.35798637
139MP0000467_abnormal_esophagus_morphology0.35692398
140MP0002909_abnormal_adrenal_gland0.35589469
141MP0002697_abnormal_eye_size0.35061084
142MP0005075_abnormal_melanosome_morpholog0.34180284
143MP0002736_abnormal_nociception_after0.32989479
144MP0004811_abnormal_neuron_physiology0.32045339
145MP0006072_abnormal_retinal_apoptosis0.31572247
146MP0004272_abnormal_basement_membrane0.31492387
147MP0005167_abnormal_blood-brain_barrier0.31185732
148MP0002084_abnormal_developmental_patter0.30857741
149MP0002249_abnormal_larynx_morphology0.29574530
150MP0003634_abnormal_glial_cell0.28834642
151MP0003786_premature_aging0.28218713
152MP0003943_abnormal_hepatobiliary_system0.28110933
153MP0006036_abnormal_mitochondrial_physio0.27828761
154MP0005266_abnormal_metabolism0.27623138
155MP0001919_abnormal_reproductive_system0.27491852
156MP0002572_abnormal_emotion/affect_behav0.27398239
157MP0003635_abnormal_synaptic_transmissio0.25711424
158MP0000432_abnormal_head_morphology0.25622448
159MP0000313_abnormal_cell_death0.25618549
160MP0006035_abnormal_mitochondrial_morpho0.25049762
161MP0009250_abnormal_appendicular_skeleto0.24860087
162MP0004381_abnormal_hair_follicle0.24593632
163MP0002116_abnormal_craniofacial_bone0.22772916
164MP0003633_abnormal_nervous_system0.22161570
165MP0009278_abnormal_bone_marrow0.21968628
166MP0004130_abnormal_muscle_cell0.21875242
167MP0002063_abnormal_learning/memory/cond0.21835032
168MP0001175_abnormal_lung_morphology0.21510880
169MP0002272_abnormal_nervous_system0.20940889
170MP0001968_abnormal_touch/_nociception0.20368213

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.52950557
2Abnormal respiratory epithelium morphology (HP:0012253)9.52950557
3Rhinitis (HP:0012384)9.05202155
4Chronic bronchitis (HP:0004469)7.32580881
5Infertility (HP:0000789)6.40766191
6Nasal polyposis (HP:0100582)6.30947338
7Bronchiectasis (HP:0002110)5.96125357
8Chronic otitis media (HP:0000389)5.26741441
9Abnormality of the nasal mucosa (HP:0000433)5.15650872
10Fragile nails (HP:0001808)4.97523706
11Milia (HP:0001056)4.85634803
12Onycholysis (HP:0001806)4.51978830
13Nephronophthisis (HP:0000090)4.24550308
14Bronchitis (HP:0012387)4.10632904
15Esophageal atresia (HP:0002032)4.07919033
16Abnormality of nail color (HP:0100643)3.79035659
17Plantar hyperkeratosis (HP:0007556)3.42303026
18Myokymia (HP:0002411)3.32113606
19Abnormality of the renal medulla (HP:0100957)3.29690655
20Thick nail (HP:0001805)3.20105254
21Recurrent sinusitis (HP:0011108)3.17861142
22Recurrent otitis media (HP:0000403)3.04612391
23Tubulointerstitial nephritis (HP:0001970)3.03684199
24Neurofibrillary tangles (HP:0002185)3.02573374
25Chronic sinusitis (HP:0011109)2.96358988
26Ridged nail (HP:0001807)2.83360102
27Atrophic scars (HP:0001075)2.83184596
28Supernumerary spleens (HP:0009799)2.81522881
29Abnormality of midbrain morphology (HP:0002418)2.72001855
30Molar tooth sign on MRI (HP:0002419)2.72001855
31Nail dystrophy (HP:0008404)2.69972170
32Vacuolated lymphocytes (HP:0001922)2.68230902
33True hermaphroditism (HP:0010459)2.66342791
34Pancreatic fibrosis (HP:0100732)2.64820789
35Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.63615874
36Medial flaring of the eyebrow (HP:0010747)2.58578864
37Large eyes (HP:0001090)2.56683184
38Fibular hypoplasia (HP:0003038)2.56011979
39Hypoplasia of dental enamel (HP:0006297)2.48438692
40Occipital encephalocele (HP:0002085)2.47956561
41Male infertility (HP:0003251)2.40848441
42Limb dystonia (HP:0002451)2.39227398
43Cerebral inclusion bodies (HP:0100314)2.38129240
44Tubular atrophy (HP:0000092)2.33240611
45Postaxial foot polydactyly (HP:0001830)2.30025603
46Congenital hepatic fibrosis (HP:0002612)2.28260383
47Oligodactyly (hands) (HP:0001180)2.26938331
48Cystic liver disease (HP:0006706)2.25583460
49Supranuclear gaze palsy (HP:0000605)2.24350525
50Achilles tendon contracture (HP:0001771)2.23265554
51Muscle fiber atrophy (HP:0100295)2.21690427
52Abnormal spermatogenesis (HP:0008669)2.13391803
53Tubulointerstitial abnormality (HP:0001969)2.11719512
54Flat capital femoral epiphysis (HP:0003370)2.06225708
55Aplasia/Hypoplasia of the tongue (HP:0010295)2.04493964
56Split foot (HP:0001839)2.03442967
57Gastrointestinal atresia (HP:0002589)2.02221222
58Abnormality of glycolipid metabolism (HP:0010969)2.00241476
59Abnormality of liposaccharide metabolism (HP:0010968)2.00241476
60Abnormality of glycosphingolipid metabolism (HP:0004343)2.00241476
61Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.9421483
62Dynein arm defect of respiratory motile cilia (HP:0012255)12.0705125
63Absent/shortened dynein arms (HP:0200106)12.0705125
64Abnormal respiratory motile cilium physiology (HP:0012261)11.8491398
65Abnormal ciliary motility (HP:0012262)10.9682266
66Aplasia/hypoplasia of the uterus (HP:0008684)1.98360530
67Abnormal blistering of the skin (HP:0008066)1.98045656
68Recurrent bronchitis (HP:0002837)1.96000920
69Bell-shaped thorax (HP:0001591)1.95279950
70Fibular aplasia (HP:0002990)1.95034915
71Pancreatic cysts (HP:0001737)1.94310577
72Apathy (HP:0000741)1.92172457
73Abnormality of placental membranes (HP:0011409)1.91820735
74Amniotic constriction ring (HP:0009775)1.91820735
75Median cleft lip (HP:0000161)1.91817839
76Midline defect of the nose (HP:0004122)1.91408549
77Cortical dysplasia (HP:0002539)1.91193270
78Pili torti (HP:0003777)1.90176180
79Alopecia of scalp (HP:0002293)1.89150881
80Oculomotor apraxia (HP:0000657)1.89147603
81Concave nail (HP:0001598)1.86984622
82Diminished motivation (HP:0000745)1.85482145
83Abnormality of the corticospinal tract (HP:0002492)1.82046818
84Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.78103388
85Gonadotropin excess (HP:0000837)1.78097799
86Abnormality of the Achilles tendon (HP:0005109)1.77839384
87Upper motor neuron abnormality (HP:0002127)1.77596830
88Abnormal hair laboratory examination (HP:0003328)1.76125289
89Congenital primary aphakia (HP:0007707)1.75695792
90Parakeratosis (HP:0001036)1.75519492
91Abnormality of the lower motor neuron (HP:0002366)1.75329865
92Renal Fanconi syndrome (HP:0001994)1.75224029
93Elevated erythrocyte sedimentation rate (HP:0003565)1.75196734
94Erythema (HP:0010783)1.74873154
95Gait imbalance (HP:0002141)1.74767025
96Sparse eyelashes (HP:0000653)1.74726682
97Fused cervical vertebrae (HP:0002949)1.74479951
98Enlarged epiphyses (HP:0010580)1.74382501
99Disinhibition (HP:0000734)1.72595425
100Facial cleft (HP:0002006)1.71867496
101Stage 5 chronic kidney disease (HP:0003774)1.71598371
102Mutism (HP:0002300)1.70253597
103Impaired proprioception (HP:0010831)1.67813259
104Shawl scrotum (HP:0000049)1.67253585
105Palmoplantar hyperkeratosis (HP:0000972)1.66596077
106Pterygium (HP:0001059)1.65692010
107Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.64707467
108Postaxial hand polydactyly (HP:0001162)1.63709055
109Abnormality of dentin (HP:0010299)1.62904410
110Oligodactyly (HP:0012165)1.61226218
111Aplasia/Hypoplasia of the fibula (HP:0006492)1.60762987
112Renal dysplasia (HP:0000110)1.60305888
11311 pairs of ribs (HP:0000878)1.57877070
114Delayed epiphyseal ossification (HP:0002663)1.57736563
115Hypoplasia of the uterus (HP:0000013)1.56859675
116Overlapping toe (HP:0001845)1.56000938
117Aplasia of the musculature (HP:0100854)1.55869766
118Palmar hyperkeratosis (HP:0010765)1.54797620
119Progressive sensorineural hearing impairment (HP:0000408)1.54702179
120Stenosis of the external auditory canal (HP:0000402)1.53802340
121Tubulointerstitial fibrosis (HP:0005576)1.52245542
122Nephrogenic diabetes insipidus (HP:0009806)1.50071112
123Anonychia (HP:0001798)1.49786426
124Impulsivity (HP:0100710)1.49051544
125Anencephaly (HP:0002323)1.48615018
126Oral leukoplakia (HP:0002745)1.48568474
127Sclerocornea (HP:0000647)1.45364906
128Abnormality of the renal cortex (HP:0011035)1.44041351
129Abnormal biliary tract physiology (HP:0012439)1.44027403
130Bile duct proliferation (HP:0001408)1.44027403
131Amyotrophic lateral sclerosis (HP:0007354)1.41019181
132Short ribs (HP:0000773)1.40278814
133Abnormality of the dental root (HP:0006486)1.39993759
134Taurodontia (HP:0000679)1.39993759
135Abnormality of permanent molar morphology (HP:0011071)1.39993759
136Chronic hepatic failure (HP:0100626)1.39404552
137Absent frontal sinuses (HP:0002688)1.34643533
138Azoospermia (HP:0000027)1.31328424
139Genital tract atresia (HP:0001827)1.29817629
140Vaginal atresia (HP:0000148)1.28965594
141Abnormality of molar morphology (HP:0011070)1.28302342
142Abnormality of molar (HP:0011077)1.28302342
143Microglossia (HP:0000171)1.27852732
144Abnormality of the dental pulp (HP:0006479)1.27550600
145Aplasia/Hypoplasia of the lens (HP:0008063)1.26829889
146Poor coordination (HP:0002370)1.26507324
147Short nail (HP:0001799)1.25053559
148Abnormal drinking behavior (HP:0030082)1.23238919
149Polydipsia (HP:0001959)1.23238919
150Hypoplastic pelvis (HP:0008839)1.21669835
151Preaxial hand polydactyly (HP:0001177)1.19240887
152Male pseudohermaphroditism (HP:0000037)1.18733161
153Abnormality of abdominal situs (HP:0011620)1.15636206
154Abdominal situs inversus (HP:0003363)1.15636206
155Nephropathy (HP:0000112)1.15612547
156Hypoplasia of the capital femoral epiphysis (HP:0003090)1.13311362
157Abnormal gallbladder physiology (HP:0012438)1.12766620
158Cholecystitis (HP:0001082)1.12766620
159Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.10586919
160Bifid tongue (HP:0010297)1.09064394
161Abnormality of renal excretion (HP:0011036)1.08748967
162Heterotopia (HP:0002282)1.06886303
163Deformed sella turcica (HP:0002681)1.06631606
164Short thorax (HP:0010306)1.06594453
165Hypodontia (HP:0000668)1.05600994
166Atelectasis (HP:0100750)1.05209448
167Furrowed tongue (HP:0000221)1.04409973
168J-shaped sella turcica (HP:0002680)1.00740584
169Aplasia/Hypoplasia of the brainstem (HP:0007362)1.00071911

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.67086406
2PDK47.67086406
3TESK15.47853583
4PDK24.95983162
5PBK4.77727355
6PNCK4.68700748
7BUB14.46545891
8PRKD34.19494725
9ICK3.60023259
10EPHB23.52140606
11LATS22.78515481
12TESK22.69235333
13PIM22.50526515
14NEK22.38777089
15PTK2B2.25287088
16STK392.03755030
17WNK41.96818352
18ARAF1.90105598
19MAPK151.77089791
20STK381.71308358
21DYRK1B1.48297499
22TRIM281.46551240
23NME21.40704123
24PLK41.34727547
25MAP3K41.31503691
26MAP2K71.27742657
27MATK1.27357170
28WEE11.20161266
29IRAK31.14403171
30PLK21.14100009
31CDK191.13593672
32MARK31.13303949
33UHMK11.12199874
34IRAK11.10389358
35WNK11.09100456
36STK31.04731825
37NTRK11.04423978
38DYRK31.00923429
39STK38L0.96544726
40TTK0.95857045
41LMTK20.94047098
42PDK10.93072592
43TYRO30.89146358
44KSR10.85239480
45CLK10.84109576
46TAOK20.83959869
47MAP3K60.79014014
48TGFBR10.77364641
49STK40.76440954
50DDR20.75851279
51CCNB10.75252169
52ABL20.74833920
53GRK70.72252022
54MAP3K120.70994762
55TBK10.69533742
56ZAK0.69314384
57EPHA30.67482339
58PKN10.64972511
59RPS6KA20.64124907
60PTK20.61660864
61PINK10.60616707
62STK100.59221583
63SIK10.58288021
64STK240.56711613
65PASK0.56482882
66CDC70.56288737
67TLK10.55102670
68TGFBR20.55040792
69CAMK1G0.54859723
70BMX0.53620328
71RPS6KA10.53476368
72GRK50.53010329
73MAP2K40.52915764
74NTRK20.52269902
75RAF10.49914276
76MAPK130.49869316
77CAMKK10.48640498
78DAPK20.48376440
79PRKCG0.47249199
80DYRK20.46459110
81INSRR0.46294990
82CHEK20.45754164
83AURKB0.45397005
84MAP3K100.45182515
85LRRK20.43959294
86AURKA0.42115986
87CHEK10.41680697
88PAK10.40736279
89IRAK20.40581234
90IKBKB0.39996910
91ATM0.36907408
92CHUK0.36871324
93MOS0.36166602
94MUSK0.35413987
95MAPK40.34523492
96BRD40.33820562
97CAMK2A0.32656285
98ROCK20.32227538
99EPHA20.30720875
100MST1R0.30163290
101MAP3K80.30076567
102ATR0.30056297
103PLK10.29748601
104NEK60.29268803
105PDPK10.29031116
106SRPK10.28783209
107RIPK40.28379981
108MINK10.20660729
109PAK20.20055878
110CDK60.19946071
111BCR0.19922978
112AKT30.19639736
113PRKAA10.18286720
114RPS6KA40.17466447
115BRSK20.16090034
116YES10.15373946
117EEF2K0.15264875
118PAK60.15251034
119RIPK10.14899107
120PRKCZ0.14737464
121FGFR20.13798804
122MAP2K60.13052007
123MTOR0.12535034
124MAP3K50.11619076
125PLK30.11592796
126CDK180.10553650
127ERBB30.10103718
128PRKACG0.10098257
129MARK20.09861120
130PRKG10.09613582
131CDK150.09512269
132BRAF0.08520269
133FRK0.08350704
134MAP3K110.08139124
135CDK120.08080099
136MARK10.07521186
137CSNK2A10.07252445
138PRKDC0.06828363
139MAPK100.06771747
140PAK40.06698738
141RPS6KB10.06676397
142CDK140.06490094
143PRKACB0.06277168
144CDK11A0.05702524
145STK160.04854224
146RPS6KA50.04848891
147LATS10.04804157
148STK110.04773416
149PRKCB0.04278934
150EIF2AK20.04182156
151FGR0.03806502
152BRSK10.03020738
153GSK3B0.01748007

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.47150227
2Pyruvate metabolism_Homo sapiens_hsa006204.41928424
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.50134041
4Steroid biosynthesis_Homo sapiens_hsa001003.45734768
5Dorso-ventral axis formation_Homo sapiens_hsa043203.22365010
6Fatty acid biosynthesis_Homo sapiens_hsa000613.06014791
7Regulation of autophagy_Homo sapiens_hsa041402.89886313
8Basal transcription factors_Homo sapiens_hsa030222.75499503
9Glucagon signaling pathway_Homo sapiens_hsa049222.64960302
10Sulfur metabolism_Homo sapiens_hsa009202.50177895
11Propanoate metabolism_Homo sapiens_hsa006402.47787511
12Huntingtons disease_Homo sapiens_hsa050162.32830179
13Ribosome_Homo sapiens_hsa030102.29952515
14Oxidative phosphorylation_Homo sapiens_hsa001902.24991004
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.20922647
16Linoleic acid metabolism_Homo sapiens_hsa005912.16403804
17Amphetamine addiction_Homo sapiens_hsa050312.08966317
18Parkinsons disease_Homo sapiens_hsa050122.01513676
19Glycerolipid metabolism_Homo sapiens_hsa005611.90053346
20Oocyte meiosis_Homo sapiens_hsa041141.88921422
21Fanconi anemia pathway_Homo sapiens_hsa034601.82545500
22Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.75773377
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.75481906
24Selenocompound metabolism_Homo sapiens_hsa004501.65947557
25Renin secretion_Homo sapiens_hsa049241.57072031
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.56601733
27Salmonella infection_Homo sapiens_hsa051321.56379130
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.52888261
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.51016662
30Glycerophospholipid metabolism_Homo sapiens_hsa005641.45104160
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.43677561
32Phagosome_Homo sapiens_hsa041451.39493775
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.37022603
34Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.35544679
35Long-term potentiation_Homo sapiens_hsa047201.34758815
36Carbohydrate digestion and absorption_Homo sapiens_hsa049731.32592412
37Hedgehog signaling pathway_Homo sapiens_hsa043401.32383007
38PPAR signaling pathway_Homo sapiens_hsa033201.30888005
39Cardiac muscle contraction_Homo sapiens_hsa042601.30528627
40Rheumatoid arthritis_Homo sapiens_hsa053231.29415448
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.27836212
42Spliceosome_Homo sapiens_hsa030401.23939607
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.23318365
44Arachidonic acid metabolism_Homo sapiens_hsa005901.21920627
45Axon guidance_Homo sapiens_hsa043601.21460533
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.20787848
47Glutathione metabolism_Homo sapiens_hsa004801.18525247
48p53 signaling pathway_Homo sapiens_hsa041151.18376992
49NOD-like receptor signaling pathway_Homo sapiens_hsa046211.17325819
50Legionellosis_Homo sapiens_hsa051341.17231975
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17152915
52Fructose and mannose metabolism_Homo sapiens_hsa000511.15917716
53Lysosome_Homo sapiens_hsa041421.15275900
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13777976
55TNF signaling pathway_Homo sapiens_hsa046681.11765973
56Pentose phosphate pathway_Homo sapiens_hsa000301.11683142
57mRNA surveillance pathway_Homo sapiens_hsa030151.09914990
58Ether lipid metabolism_Homo sapiens_hsa005651.07620324
59Shigellosis_Homo sapiens_hsa051311.07609540
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06219758
61* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.04286644
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.03449670
63Nicotine addiction_Homo sapiens_hsa050331.00666583
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97039651
65Carbon metabolism_Homo sapiens_hsa012000.94166809
66Mineral absorption_Homo sapiens_hsa049780.94048541
67Estrogen signaling pathway_Homo sapiens_hsa049150.93743812
68Type II diabetes mellitus_Homo sapiens_hsa049300.93584518
69Fat digestion and absorption_Homo sapiens_hsa049750.93255030
70RNA transport_Homo sapiens_hsa030130.91107993
71Malaria_Homo sapiens_hsa051440.90906312
72* Cell cycle_Homo sapiens_hsa041100.90854663
73Calcium signaling pathway_Homo sapiens_hsa040200.88717388
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88681068
75Chemical carcinogenesis_Homo sapiens_hsa052040.87703011
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86770774
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85662232
78Purine metabolism_Homo sapiens_hsa002300.84590933
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.83446392
80Amoebiasis_Homo sapiens_hsa051460.83410934
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83240895
82GABAergic synapse_Homo sapiens_hsa047270.79928895
83Antigen processing and presentation_Homo sapiens_hsa046120.79658762
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77778494
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77618517
86Toxoplasmosis_Homo sapiens_hsa051450.77360964
87Folate biosynthesis_Homo sapiens_hsa007900.76726832
88ECM-receptor interaction_Homo sapiens_hsa045120.76618578
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75585084
90Collecting duct acid secretion_Homo sapiens_hsa049660.75184349
91* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73408918
92Herpes simplex infection_Homo sapiens_hsa051680.73080134
93Pertussis_Homo sapiens_hsa051330.72650779
94Synaptic vesicle cycle_Homo sapiens_hsa047210.72119504
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71495017
96Influenza A_Homo sapiens_hsa051640.71449688
97Apoptosis_Homo sapiens_hsa042100.71179387
98Basal cell carcinoma_Homo sapiens_hsa052170.70910881
99Gap junction_Homo sapiens_hsa045400.70194256
100RNA polymerase_Homo sapiens_hsa030200.70098406
101African trypanosomiasis_Homo sapiens_hsa051430.68215342
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67907126
103Osteoclast differentiation_Homo sapiens_hsa043800.66516288
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66104775
105Salivary secretion_Homo sapiens_hsa049700.66068953
106Prion diseases_Homo sapiens_hsa050200.65020393
107Serotonergic synapse_Homo sapiens_hsa047260.63751114
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63311455
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62993995
110Wnt signaling pathway_Homo sapiens_hsa043100.62845985
111Glutamatergic synapse_Homo sapiens_hsa047240.61671507
112Tuberculosis_Homo sapiens_hsa051520.60840152
113Alcoholism_Homo sapiens_hsa050340.60350694
114Systemic lupus erythematosus_Homo sapiens_hsa053220.60171077
115Vibrio cholerae infection_Homo sapiens_hsa051100.59357061
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59233630
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58684123
118Cocaine addiction_Homo sapiens_hsa050300.58646787
119Circadian entrainment_Homo sapiens_hsa047130.58225653
120Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57314129
121Thyroid hormone synthesis_Homo sapiens_hsa049180.57024384
122Phototransduction_Homo sapiens_hsa047440.56063433
123Dilated cardiomyopathy_Homo sapiens_hsa054140.55584333
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55159891
125Biosynthesis of amino acids_Homo sapiens_hsa012300.54502517
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54423800
127Olfactory transduction_Homo sapiens_hsa047400.53312010
128Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53281804
129Insulin secretion_Homo sapiens_hsa049110.52810700
130Fatty acid metabolism_Homo sapiens_hsa012120.52612434
131Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50422968
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.49734091
133Small cell lung cancer_Homo sapiens_hsa052220.49484756
134Gastric acid secretion_Homo sapiens_hsa049710.48673459
135* Viral carcinogenesis_Homo sapiens_hsa052030.48487108
136cAMP signaling pathway_Homo sapiens_hsa040240.48001974
137Fatty acid degradation_Homo sapiens_hsa000710.46550403
138Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46493848
139Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45288778
140Taste transduction_Homo sapiens_hsa047420.45137745
141VEGF signaling pathway_Homo sapiens_hsa043700.44438181
142Dopaminergic synapse_Homo sapiens_hsa047280.44331244
143Inositol phosphate metabolism_Homo sapiens_hsa005620.42682172
144SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42612895
145Glycosaminoglycan degradation_Homo sapiens_hsa005310.41728928
146Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41007132
147Central carbon metabolism in cancer_Homo sapiens_hsa052300.40764365
148Tight junction_Homo sapiens_hsa045300.40718238
149Endocytosis_Homo sapiens_hsa041440.39984901
150* Epstein-Barr virus infection_Homo sapiens_hsa051690.39922741
151ABC transporters_Homo sapiens_hsa020100.39654116
152Morphine addiction_Homo sapiens_hsa050320.37540436
153Bile secretion_Homo sapiens_hsa049760.37065465
154Bladder cancer_Homo sapiens_hsa052190.36864727
155* Hepatitis B_Homo sapiens_hsa051610.35465535
156Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.33864815
157Vascular smooth muscle contraction_Homo sapiens_hsa042700.33031282
158Alzheimers disease_Homo sapiens_hsa050100.32552301
159Retinol metabolism_Homo sapiens_hsa008300.29828080
160Pancreatic secretion_Homo sapiens_hsa049720.28593226
161Metabolic pathways_Homo sapiens_hsa011000.27759258
162Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23247433
163Oxytocin signaling pathway_Homo sapiens_hsa049210.22681298
164Aldosterone synthesis and secretion_Homo sapiens_hsa049250.22259744
165Renin-angiotensin system_Homo sapiens_hsa046140.21804229
166Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21784638
167Pyrimidine metabolism_Homo sapiens_hsa002400.21087622

Most similar genes based on co-expression Upload to Enrichr

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