CCNB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* mitotic metaphase plate congression (GO:0007080)5.78906305
2protein localization to kinetochore (GO:0034501)5.58058506
3attachment of spindle microtubules to kinetochore (GO:0008608)5.23467329
4mitotic sister chromatid segregation (GO:0000070)5.03333161
5protein localization to chromosome, centromeric region (GO:0071459)4.96583380
6* metaphase plate congression (GO:0051310)4.95618024
7CENP-A containing nucleosome assembly (GO:0034080)4.89488474
8kinetochore organization (GO:0051383)4.79889573
9chromatin remodeling at centromere (GO:0031055)4.75087826
10mitotic chromosome condensation (GO:0007076)4.68358671
11* regulation of spindle organization (GO:0090224)4.63599114
12kinetochore assembly (GO:0051382)4.56297333
13sister chromatid segregation (GO:0000819)4.54118242
14establishment of integrated proviral latency (GO:0075713)4.54105800
15* establishment of chromosome localization (GO:0051303)4.48185202
16DNA replication checkpoint (GO:0000076)4.43981247
17DNA ligation (GO:0006266)4.42129928
18purine nucleobase biosynthetic process (GO:0009113)4.40838205
19DNA replication-independent nucleosome organization (GO:0034724)4.39731419
20DNA replication-independent nucleosome assembly (GO:0006336)4.39731419
21nucleobase biosynthetic process (GO:0046112)4.31538400
22* mitotic nuclear envelope disassembly (GO:0007077)4.24348139
23negative regulation of chromosome segregation (GO:0051985)4.23315197
24* spindle checkpoint (GO:0031577)4.23095656
25histone exchange (GO:0043486)4.22827636
26negative regulation of mitotic metaphase/anaphase transition (GO:0045841)4.20411103
27negative regulation of sister chromatid segregation (GO:0033046)4.20411103
28negative regulation of mitotic sister chromatid separation (GO:2000816)4.20411103
29negative regulation of mitotic sister chromatid segregation (GO:0033048)4.20411103
30* regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.18632913
31spindle assembly checkpoint (GO:0071173)4.17677962
32negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)4.17315005
33mitotic spindle assembly checkpoint (GO:0007094)4.14305441
34DNA replication initiation (GO:0006270)4.13081247
35regulation of mitotic metaphase/anaphase transition (GO:0030071)4.08880790
36* regulation of chromosome segregation (GO:0051983)4.07552597
37regulation of metaphase/anaphase transition of cell cycle (GO:1902099)4.06750403
38ribosome assembly (GO:0042255)3.99784236
39DNA topological change (GO:0006265)3.98149832
40protein localization to chromosome (GO:0034502)3.95021939
41nuclear pore organization (GO:0006999)3.95005457
42regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.93477481
43* nuclear envelope disassembly (GO:0051081)3.93015841
44* membrane disassembly (GO:0030397)3.93015841
45DNA replication-dependent nucleosome assembly (GO:0006335)3.91423464
46DNA replication-dependent nucleosome organization (GO:0034723)3.91423464
47* mitotic spindle checkpoint (GO:0071174)3.89292285
48regulation of mitotic sister chromatid separation (GO:0010965)3.88647827
49regulation of mitotic sister chromatid segregation (GO:0033047)3.88647827
50regulation of sister chromatid segregation (GO:0033045)3.88647827
51DNA strand elongation involved in DNA replication (GO:0006271)3.88487427
52meiotic chromosome segregation (GO:0045132)3.85497460
53chromosome segregation (GO:0007059)3.80598443
54proteasome assembly (GO:0043248)3.77910132
55positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.75743618
56positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.75743618
57positive regulation of mitotic sister chromatid separation (GO:1901970)3.75743618
58DNA strand elongation (GO:0022616)3.68960533
59ribosome biogenesis (GO:0042254)3.67994163
60DNA unwinding involved in DNA replication (GO:0006268)3.62093233
61nuclear pore complex assembly (GO:0051292)3.60202440
62regulation of centrosome cycle (GO:0046605)3.59577846
63* positive regulation of chromosome segregation (GO:0051984)3.56000924
64microtubule depolymerization (GO:0007019)3.55352048
65telomere maintenance via semi-conservative replication (GO:0032201)3.53531012
66protein K6-linked ubiquitination (GO:0085020)3.53396541
67maturation of 5.8S rRNA (GO:0000460)3.50574994
68establishment of viral latency (GO:0019043)3.47749737
69regulation of exit from mitosis (GO:0007096)3.46931867
70negative regulation of ligase activity (GO:0051352)3.45112954
71negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.45112954
72formation of translation preinitiation complex (GO:0001731)3.44313924
73* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.43921238
74mitotic recombination (GO:0006312)3.41702454
75mitotic sister chromatid cohesion (GO:0007064)3.41533668
76regulation of centriole replication (GO:0046599)3.40702299
77DNA packaging (GO:0006323)3.39958579
78regulation of double-strand break repair via homologous recombination (GO:0010569)3.39752269
79protein complex localization (GO:0031503)3.39140703
80histone-serine phosphorylation (GO:0035404)3.38148747
81pore complex assembly (GO:0046931)3.37822572
82telomere maintenance via recombination (GO:0000722)3.37379913
83negative regulation of mitosis (GO:0045839)3.37367392
84rRNA modification (GO:0000154)3.36812516
85maturation of SSU-rRNA (GO:0030490)3.36326889
86chromatin assembly or disassembly (GO:0006333)3.29412555
87* regulation of mitotic spindle organization (GO:0060236)3.28133985
88ATP-dependent chromatin remodeling (GO:0043044)3.23745790
89regulation of sister chromatid cohesion (GO:0007063)3.22361084
90spliceosomal snRNP assembly (GO:0000387)3.20987264
91* nuclear envelope organization (GO:0006998)3.17217996
92* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.16031681
93telomere maintenance via telomere lengthening (GO:0010833)3.13782086
94negative regulation of cell division (GO:0051782)3.13445202
95* mitotic cell cycle (GO:0000278)3.12444882
96chromosome condensation (GO:0030261)3.12379142
97double-strand break repair via nonhomologous end joining (GO:0006303)3.10410739
98non-recombinational repair (GO:0000726)3.10410739
99nucleotide-excision repair, DNA gap filling (GO:0006297)3.10222177
100negative regulation of proteasomal protein catabolic process (GO:1901799)3.07770419
101ribonucleoprotein complex biogenesis (GO:0022613)3.07514427
102regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.06948324
103spindle assembly involved in mitosis (GO:0090307)3.06549465
104folic acid metabolic process (GO:0046655)3.06539092
105mitotic G2/M transition checkpoint (GO:0044818)3.06058721
106regulation of spindle checkpoint (GO:0090231)3.05611766
107rRNA processing (GO:0006364)3.05373215
108regulation of telomere maintenance via telomerase (GO:0032210)3.05307788
109mitotic spindle organization (GO:0007052)3.04434192
110IMP biosynthetic process (GO:0006188)3.03313388
111negative regulation of nuclear division (GO:0051784)3.03017443
112negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.02475539
113mitotic cytokinesis (GO:0000281)3.02287766
1147-methylguanosine mRNA capping (GO:0006370)3.01092532
115negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)3.00463921
116transcription-coupled nucleotide-excision repair (GO:0006283)3.00416797
117* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.99758465
118folic acid-containing compound biosynthetic process (GO:0009396)2.98110948
119rRNA metabolic process (GO:0016072)2.96764298
120termination of RNA polymerase I transcription (GO:0006363)2.95066525
121RNA capping (GO:0036260)2.94938032
1227-methylguanosine RNA capping (GO:0009452)2.94938032

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.18869597
2* FOXM1_23109430_ChIP-Seq_U2OS_Human6.34241821
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.24024399
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.11199002
5MYC_18555785_ChIP-Seq_MESCs_Mouse4.05936830
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.49162920
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.01536107
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.99536860
9* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.92801813
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.91641061
11AR_21909140_ChIP-Seq_LNCAP_Human2.88999422
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.84629546
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.80864060
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.79493335
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.77871040
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.76107336
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.74973297
18* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.65410929
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.44610101
20* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.24922503
21XRN2_22483619_ChIP-Seq_HELA_Human2.24479025
22* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.21408115
23* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.18573339
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.17369914
25VDR_23849224_ChIP-Seq_CD4+_Human2.15779431
26E2F1_21310950_ChIP-Seq_MCF-7_Human2.10562632
27NANOG_18555785_ChIP-Seq_MESCs_Mouse2.06016863
28* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.98630728
29E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96282996
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91623308
31DCP1A_22483619_ChIP-Seq_HELA_Human1.89525524
32FOXP3_21729870_ChIP-Seq_TREG_Human1.87057980
33GABP_19822575_ChIP-Seq_HepG2_Human1.83260884
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81443933
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.81361341
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.77930599
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76222433
38TTF2_22483619_ChIP-Seq_HELA_Human1.73418051
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.66398701
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64745368
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63791259
42KDM5A_27292631_Chip-Seq_BREAST_Human1.52661160
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.52421810
44ELK1_19687146_ChIP-ChIP_HELA_Human1.50291644
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49881642
46CIITA_25753668_ChIP-Seq_RAJI_Human1.45018827
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.43391649
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41621982
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.39958997
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.37994070
51POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37681574
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.36896047
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33503887
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31389114
55SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.31045117
56PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.30966987
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30419409
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29394070
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29109377
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25726817
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23946503
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.20344871
63E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20176154
64STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18875572
65ELF1_17652178_ChIP-ChIP_JURKAT_Human1.18671205
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17922139
67RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17281412
68SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17122630
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16125263
70NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09922759
71CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.09776369
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08212907
73NANOG_16153702_ChIP-ChIP_HESCs_Human1.07283487
74NANOG_21062744_ChIP-ChIP_HESCs_Human1.06162408
75DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03142336
76MYC_18940864_ChIP-ChIP_HL60_Human1.01272393
77SOX2_16153702_ChIP-ChIP_HESCs_Human1.00005754
78MYC_22102868_ChIP-Seq_BL_Human0.98867540
79CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98495744
80PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98358543
81TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97971044
82* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97715330
83SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97031387
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95998412
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93630447
86ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93052195
87TCF3_18692474_ChIP-Seq_MEFs_Mouse0.91533249
88CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90587438
89SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89962681
90TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.89781487
91* TFEB_21752829_ChIP-Seq_HELA_Human0.88081826
92ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88058191
93NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.86675634
94CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86286145
95DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86178603
96NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.84685971
97POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83433900
98BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83423810
99ESR1_15608294_ChIP-ChIP_MCF-7_Human0.82933396
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.81468984
101KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.80685475
102KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.80685475
103KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.80685475
104CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.80339853
105ELK1_22589737_ChIP-Seq_MCF10A_Human0.80019037
106* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.79219475
107SOX2_18692474_ChIP-Seq_MEFs_Mouse0.78808102
108KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77502592
109HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.75315550
110FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.74574671
111TCF3_18692474_ChIP-Seq_MESCs_Mouse0.74049430
112SOX17_20123909_ChIP-Seq_XEN_Mouse0.73773347
113NOTCH1_21737748_ChIP-Seq_TLL_Human0.72712055
114EWS_26573619_Chip-Seq_HEK293_Human0.70557219
115TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.70468621

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.52294630
2MP0003111_abnormal_nucleus_morphology5.41442231
3MP0010094_abnormal_chromosome_stability5.09099418
4MP0004957_abnormal_blastocyst_morpholog4.66568204
5MP0003077_abnormal_cell_cycle4.56093694
6MP0008057_abnormal_DNA_replication3.73248237
7MP0008058_abnormal_DNA_repair3.29831366
8MP0003718_maternal_effect3.25529633
9MP0003123_paternal_imprinting2.99415038
10MP0008007_abnormal_cellular_replicative2.94962572
11MP0008932_abnormal_embryonic_tissue2.88385244
12MP0001730_embryonic_growth_arrest2.55796234
13MP0008877_abnormal_DNA_methylation2.54654839
14MP0000350_abnormal_cell_proliferation2.34904616
15MP0003786_premature_aging2.17938243
16MP0009697_abnormal_copulation2.14074566
17MP0010307_abnormal_tumor_latency2.06549086
18MP0005380_embryogenesis_phenotype1.95752295
19MP0001672_abnormal_embryogenesis/_devel1.95752295
20MP0001697_abnormal_embryo_size1.87082630
21MP0002085_abnormal_embryonic_tissue1.69903277
22MP0003984_embryonic_growth_retardation1.66433885
23* MP0002080_prenatal_lethality1.63191742
24MP0002210_abnormal_sex_determination1.62499724
25MP0002088_abnormal_embryonic_growth/wei1.62334329
26MP0002396_abnormal_hematopoietic_system1.59222169
27MP0002084_abnormal_developmental_patter1.48496455
28MP0003315_abnormal_perineum_morphology1.41875013
29MP0001929_abnormal_gametogenesis1.40340838
30MP0002086_abnormal_extraembryonic_tissu1.40261838
31MP0003121_genomic_imprinting1.39200248
32MP0003567_abnormal_fetal_cardiomyocyte1.38913132
33MP0001145_abnormal_male_reproductive1.38767643
34MP0010352_gastrointestinal_tract_polyps1.34890437
35MP0010030_abnormal_orbit_morphology1.33664819
36MP0000313_abnormal_cell_death1.33507665
37MP0000653_abnormal_sex_gland1.32605161
38MP0002102_abnormal_ear_morphology1.32482510
39MP0006292_abnormal_olfactory_placode1.27885478
40MP0003937_abnormal_limbs/digits/tail_de1.26624876
41MP0002019_abnormal_tumor_incidence1.24098233
42MP0006035_abnormal_mitochondrial_morpho1.23820482
43MP0000490_abnormal_crypts_of1.20905259
44MP0008789_abnormal_olfactory_epithelium1.20880162
45MP0004197_abnormal_fetal_growth/weight/1.20544235
46MP0003941_abnormal_skin_development1.18747462
47MP0001119_abnormal_female_reproductive1.16532788
48MP0002697_abnormal_eye_size1.13601609
49MP0008260_abnormal_autophagy1.12147557
50MP0001293_anophthalmia1.11521730
51MP0002653_abnormal_ependyma_morphology1.10085124
52MP0005395_other_phenotype1.06661364
53MP0005076_abnormal_cell_differentiation1.03546752
54MP0001346_abnormal_lacrimal_gland1.03444321
55MP0003136_yellow_coat_color0.99161764
56MP0009672_abnormal_birth_weight0.98480663
57MP0006036_abnormal_mitochondrial_physio0.97269964
58MP0009333_abnormal_splenocyte_physiolog0.97256867
59MP0003890_abnormal_embryonic-extraembry0.96600300
60MP0004808_abnormal_hematopoietic_stem0.96541074
61MP0002233_abnormal_nose_morphology0.96210881
62MP0003699_abnormal_female_reproductive0.94578358
63MP0002160_abnormal_reproductive_system0.93527857
64MP0003950_abnormal_plasma_membrane0.91027293
65MP0001529_abnormal_vocalization0.90496856
66MP0005389_reproductive_system_phenotype0.89875201
67MP0003221_abnormal_cardiomyocyte_apopto0.88856799
68MP0002877_abnormal_melanocyte_morpholog0.88080235
69MP0003119_abnormal_digestive_system0.86998234
70MP0005394_taste/olfaction_phenotype0.85999295
71MP0005499_abnormal_olfactory_system0.85999295
72MP0009053_abnormal_anal_canal0.83846223
73MP0002111_abnormal_tail_morphology0.83363012
74MP0005621_abnormal_cell_physiology0.82492709
75MP0005451_abnormal_body_composition0.82067466
76MP0005501_abnormal_skin_physiology0.81943779
77MP0000579_abnormal_nail_morphology0.80867559
78MP0005384_cellular_phenotype0.80632757
79MP0000372_irregular_coat_pigmentation0.79965864
80MP0010234_abnormal_vibrissa_follicle0.79215315
81MP0003878_abnormal_ear_physiology0.77948005
82MP0005377_hearing/vestibular/ear_phenot0.77948005
83MP0002161_abnormal_fertility/fecundity0.77516743
84MP0003938_abnormal_ear_development0.76923146
85MP0002796_impaired_skin_barrier0.76273531
86MP0001545_abnormal_hematopoietic_system0.76153971
87MP0005397_hematopoietic_system_phenotyp0.76153971
88MP0000647_abnormal_sebaceous_gland0.74470002
89MP0000537_abnormal_urethra_morphology0.74238591
90MP0000762_abnormal_tongue_morphology0.74104809
91MP0000049_abnormal_middle_ear0.73527341
92MP0002132_abnormal_respiratory_system0.73180022
93MP0003806_abnormal_nucleotide_metabolis0.72848820
94MP0000566_synostosis0.72231452
95MP0004264_abnormal_extraembryonic_tissu0.72105843
96MP0009703_decreased_birth_body0.71628853
97MP0003698_abnormal_male_reproductive0.70702364
98MP0000358_abnormal_cell_content/0.70464593
99MP0000428_abnormal_craniofacial_morphol0.70013336
100MP0002234_abnormal_pharynx_morphology0.69393184
101MP0001286_abnormal_eye_development0.66524837
102MP0001727_abnormal_embryo_implantation0.65716993
103MP0002092_abnormal_eye_morphology0.63914349
104MP0001919_abnormal_reproductive_system0.63198013
105MP0000703_abnormal_thymus_morphology0.62992515
106MP0000432_abnormal_head_morphology0.61697361
107MP0003755_abnormal_palate_morphology0.59274840
108MP0001881_abnormal_mammary_gland0.57595861
109MP0009379_abnormal_foot_pigmentation0.57465886
110MP0004233_abnormal_muscle_weight0.56943366
111MP0001915_intracranial_hemorrhage0.56767715
112MP0003385_abnormal_body_wall0.56679019
113MP0000750_abnormal_muscle_regeneration0.56046422
114MP0005171_absent_coat_pigmentation0.55765237
115MP0005623_abnormal_meninges_morphology0.55675525
116MP0002722_abnormal_immune_system0.54296535
117MP0003936_abnormal_reproductive_system0.54066770
118MP0001849_ear_inflammation0.54028952
119MP0003935_abnormal_craniofacial_develop0.52610479
120MP0005408_hypopigmentation0.52272144
121MP0000627_abnormal_mammary_gland0.52018357
122MP0003186_abnormal_redox_activity0.51920321
123MP0003861_abnormal_nervous_system0.50583714
124MP0000383_abnormal_hair_follicle0.49942715
125MP0000689_abnormal_spleen_morphology0.49727251
126MP0002127_abnormal_cardiovascular_syste0.49287854
127MP0002938_white_spotting0.48571380
128MP0008995_early_reproductive_senescence0.48033228
129MP0002114_abnormal_axial_skeleton0.47154905
130MP0005023_abnormal_wound_healing0.46362852

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.65298478
2Breast hypoplasia (HP:0003187)5.06952276
3Chromsome breakage (HP:0040012)4.34356590
4Patellar aplasia (HP:0006443)4.32994739
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.21911425
6Impulsivity (HP:0100710)4.19898132
7Carpal bone hypoplasia (HP:0001498)4.14957966
8Aplasia/Hypoplasia of the patella (HP:0006498)4.13138807
9Abnormality of the labia minora (HP:0012880)3.79304629
10Meckel diverticulum (HP:0002245)3.47702163
11Absent radius (HP:0003974)3.39374624
12Abnormality of chromosome stability (HP:0003220)3.39281871
13Abnormality of the preputium (HP:0100587)3.34076272
14Cerebral hypomyelination (HP:0006808)3.29849079
15Abnormality of the ileum (HP:0001549)3.27513410
16Oral leukoplakia (HP:0002745)3.23236231
17Duodenal stenosis (HP:0100867)3.22398676
18Small intestinal stenosis (HP:0012848)3.22398676
19Rough bone trabeculation (HP:0100670)3.22177450
20Aplasia involving forearm bones (HP:0009822)3.18319889
21Absent forearm bone (HP:0003953)3.18319889
22Degeneration of anterior horn cells (HP:0002398)3.18012911
23Abnormality of the anterior horn cell (HP:0006802)3.18012911
24Aplasia/Hypoplasia of the uvula (HP:0010293)3.06538581
25Cortical dysplasia (HP:0002539)2.99629433
26Supernumerary spleens (HP:0009799)2.98726927
27Aplasia/Hypoplasia of the sacrum (HP:0008517)2.98379561
28Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.98310818
29Abnormal lung lobation (HP:0002101)2.94418594
30Selective tooth agenesis (HP:0001592)2.86015585
31Facial hemangioma (HP:0000329)2.82645752
32Reticulocytopenia (HP:0001896)2.82415563
33Premature ovarian failure (HP:0008209)2.73579974
34Medulloblastoma (HP:0002885)2.68762742
35Colon cancer (HP:0003003)2.67509747
36Sloping forehead (HP:0000340)2.66705810
37Myelodysplasia (HP:0002863)2.63585347
38Abnormality of the duodenum (HP:0002246)2.61537344
39Hypoplasia of the capital femoral epiphysis (HP:0003090)2.60160479
40Horseshoe kidney (HP:0000085)2.58601413
41Secondary amenorrhea (HP:0000869)2.57087929
42Abnormality of glycolysis (HP:0004366)2.52970878
43Ependymoma (HP:0002888)2.52456623
44Volvulus (HP:0002580)2.52366604
45Ureteral duplication (HP:0000073)2.51151143
46Increased serum pyruvate (HP:0003542)2.48104550
47Absent thumb (HP:0009777)2.47824774
48Bone marrow hypocellularity (HP:0005528)2.47744496
49Microvesicular hepatic steatosis (HP:0001414)2.45933089
50Ectopic kidney (HP:0000086)2.40308969
51Abnormal trabecular bone morphology (HP:0100671)2.39588603
52Aplasia/Hypoplasia of the sternum (HP:0006714)2.37766549
53Duplicated collecting system (HP:0000081)2.34394745
54Oligodactyly (HP:0012165)2.30777209
55Rhabdomyosarcoma (HP:0002859)2.30278100
56Neoplasm of the pancreas (HP:0002894)2.29043638
57Abnormality of the fetal cardiovascular system (HP:0010948)2.28586702
58Abnormal umbilical cord blood vessels (HP:0011403)2.28586702
59Single umbilical artery (HP:0001195)2.28586702
60Short thumb (HP:0009778)2.25926419
61Nephroblastoma (Wilms tumor) (HP:0002667)2.24760589
62Hypoplastic pelvis (HP:0008839)2.21245028
63Microretrognathia (HP:0000308)2.19491719
64Oligodactyly (hands) (HP:0001180)2.16618854
65Cafe-au-lait spot (HP:0000957)2.16422479
66Premature graying of hair (HP:0002216)2.14927464
67Atresia of the external auditory canal (HP:0000413)2.13180140
68Breast aplasia (HP:0100783)2.13035708
69Facial cleft (HP:0002006)2.12653860
70Irregular epiphyses (HP:0010582)2.12403142
71Abnormal spermatogenesis (HP:0008669)2.12030275
72Triphalangeal thumb (HP:0001199)2.11639982
73Tracheoesophageal fistula (HP:0002575)2.11417147
74Choanal atresia (HP:0000453)2.10700946
75Aplasia/Hypoplasia of the breasts (HP:0010311)2.10418279
76Embryonal neoplasm (HP:0002898)2.10280704
77Agnosia (HP:0010524)2.10046751
78Capillary hemangiomas (HP:0005306)2.08564709
79Embryonal renal neoplasm (HP:0011794)2.08030249
80Cleft eyelid (HP:0000625)2.07030178
81Increased nuchal translucency (HP:0010880)2.06163972
82Abnormality of the proximal phalanges of the hand (HP:0009834)2.05817950
83Abnormality of the septum pellucidum (HP:0007375)2.04887933
84Aplastic anemia (HP:0001915)2.04010804
85Multiple enchondromatosis (HP:0005701)2.03750098
86Abnormality of the umbilical cord (HP:0010881)2.03063027
87CNS hypomyelination (HP:0003429)1.99940005
88Abnormality of the renal collecting system (HP:0004742)1.99703037
89Clubbing of toes (HP:0100760)1.99316150
90Entropion (HP:0000621)1.99185466
91Absent septum pellucidum (HP:0001331)1.97120715
92Aplasia/Hypoplasia of the earlobes (HP:0009906)1.96947402
93Acute encephalopathy (HP:0006846)1.96151959
94Male infertility (HP:0003251)1.96017593
95Abnormal number of incisors (HP:0011064)1.96006522
96Shawl scrotum (HP:0000049)1.95979750
97Squamous cell carcinoma (HP:0002860)1.94718355
98Abnormality of the carotid arteries (HP:0005344)1.94232334
99Abnormality of methionine metabolism (HP:0010901)1.94122779
100Acute necrotizing encephalopathy (HP:0006965)1.94091610
101Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.93344857
102Absent epiphyses (HP:0010577)1.93344857
103Trismus (HP:0000211)1.93148242
104Cellular immunodeficiency (HP:0005374)1.93081580
105Abnormality of cells of the erythroid lineage (HP:0012130)1.92360857
106Hyperglycinemia (HP:0002154)1.90920916
107Spinal muscular atrophy (HP:0007269)1.90070862
108Atrophy/Degeneration involving motor neurons (HP:0007373)1.88536068
109Aplasia/Hypoplasia involving the musculature (HP:0001460)1.87919510
110Increased hepatocellular lipid droplets (HP:0006565)1.87894716
111Prominent nose (HP:0000448)1.87744884
112Proximal placement of thumb (HP:0009623)1.84850326
113Abnormal number of erythroid precursors (HP:0012131)1.83828856
114Flat capital femoral epiphysis (HP:0003370)1.83509240
115Progressive external ophthalmoplegia (HP:0000590)1.83106791
116Overlapping toe (HP:0001845)1.82880057
117Aplasia/hypoplasia of the humerus (HP:0006507)1.82389637
118Short middle phalanx of the 5th finger (HP:0004220)1.82125826
11911 pairs of ribs (HP:0000878)1.81627999
120Abnormal mitochondria in muscle tissue (HP:0008316)1.81461854
121Deviation of the thumb (HP:0009603)1.80181085
122Neoplasm of the colon (HP:0100273)1.79484657
123Reduced antithrombin III activity (HP:0001976)1.78154856
124Glioma (HP:0009733)1.76579606
125Pancytopenia (HP:0001876)1.75939402
126Sparse eyelashes (HP:0000653)1.75555180
127Abnormalities of placenta or umbilical cord (HP:0001194)1.75000100
128Type I transferrin isoform profile (HP:0003642)1.73437380
129Septo-optic dysplasia (HP:0100842)1.71459648
130Arteriovenous malformation (HP:0100026)1.70394147
131Macrocytic anemia (HP:0001972)1.69737396
132Progressive muscle weakness (HP:0003323)1.69348998
133Increased CSF lactate (HP:0002490)1.68212903
134Duplication of thumb phalanx (HP:0009942)1.67319340
135Sensory axonal neuropathy (HP:0003390)1.64649109
136Shoulder girdle muscle weakness (HP:0003547)1.64507000
137Ovarian neoplasm (HP:0100615)1.64213582
138Increased serum lactate (HP:0002151)1.63602645
139Cholecystitis (HP:0001082)1.61185033
140Abnormal gallbladder physiology (HP:0012438)1.61185033
141Megaloblastic anemia (HP:0001889)1.58588392
142Median cleft lip (HP:0000161)1.58561500

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.86235835
2WEE14.87786703
3CDC73.49856695
4NEK23.29926571
5EIF2AK13.23724161
6TTK3.18751185
7BRSK23.13983240
8PLK42.98904088
9NEK12.48053313
10VRK22.42252988
11* PLK12.41266265
12SRPK12.36296938
13BRSK12.24555985
14TSSK62.07180788
15AURKB1.90010598
16ACVR1B1.89135226
17MKNK11.80636698
18MKNK21.73065288
19CCNB11.70570833
20CHEK21.70216901
21* PLK31.63382995
22MST41.61523908
23EIF2AK31.57664382
24AURKA1.54469092
25VRK11.48795003
26CDK71.44862230
27MAP3K81.42377015
28TRIM281.40212132
29STK161.38580283
30EPHA21.37019771
31DYRK31.36889389
32STK101.35448713
33BRAF1.34299239
34ATR1.33456984
35STK38L1.23881270
36TAF11.21187170
37CHEK11.21072609
38ZAK1.20611903
39TESK21.17404401
40MELK1.12193958
41RPS6KA41.12099060
42STK41.11353795
43LATS21.10781358
44STK31.08323240
45CDK41.08285690
46RPS6KB21.05164956
47NME11.04630777
48NME21.04227941
49TLK11.03410740
50AKT30.96924520
51PNCK0.91876129
52CDK120.90489320
53EIF2AK20.87716334
54EEF2K0.86603347
55MST1R0.86316667
56SCYL20.82154047
57PASK0.81193057
58ATM0.80990897
59CDK20.78662732
60LATS10.77994262
61PAK10.72370592
62SMG10.72004105
63PBK0.70047579
64* CDK10.68185733
65CDK80.62964365
66PRKCI0.62917697
67PAK40.59841302
68MET0.58982953
69PDK40.58959721
70PDK30.58959721
71ALK0.58127141
72CSNK2A10.52880683
73MARK30.52161100
74PIM10.52154623
75CDK60.49368341
76TNIK0.49152751
77MAP3K100.48446903
78CSNK2A20.47113198
79DYRK20.44404642
80RAF10.42362949
81PLK20.42261095
82CSNK1G30.41187311
83CDK180.39368917
84TGFBR10.38656582
85ERBB30.37959565
86NUAK10.36707979
87WNK30.36570111
88PDK20.36394349
89MAP3K60.35293261
90ARAF0.33402660
91MAP3K90.32706223
92MOS0.32419883
93CDK140.32383766
94CDK90.31818887
95CSNK1E0.31674716
96FGFR10.30156377
97NEK60.30077575
98NEK90.29953580
99BRD40.29939061
100CSNK1G10.29671670
101RPS6KA50.27587249
102MAPKAPK30.26674267
103AKT20.24917573
104BCR0.24625931
105CSNK1A1L0.24574972
106PRKDC0.23160071
107ERBB40.20259467
108CLK10.20196322
109STK240.19137583
110MTOR0.18963524
111DMPK0.18425213
112ILK0.17719769
113MAPK140.17006546
114PAK20.15515955
115ABL20.13120630
116GSK3B0.12684629
117PRKAA10.11543491
118CDK30.11447183
119CSNK1D0.11400106
120KSR10.10629372
121MAP3K50.09131483
122AKT10.09121269
123CDK11A0.08893063
124CDK150.08367762

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.31679635
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.23449864
3Mismatch repair_Homo sapiens_hsa034303.87271410
4RNA polymerase_Homo sapiens_hsa030203.83685223
5RNA transport_Homo sapiens_hsa030133.57439737
6* Cell cycle_Homo sapiens_hsa041103.48894514
7Vitamin B6 metabolism_Homo sapiens_hsa007503.24334853
8Spliceosome_Homo sapiens_hsa030403.20845271
9Homologous recombination_Homo sapiens_hsa034403.15217149
10Proteasome_Homo sapiens_hsa030503.04095203
11Base excision repair_Homo sapiens_hsa034102.95838252
12Nucleotide excision repair_Homo sapiens_hsa034202.83581537
13Basal transcription factors_Homo sapiens_hsa030222.54555025
14Fanconi anemia pathway_Homo sapiens_hsa034602.51955396
15Pyrimidine metabolism_Homo sapiens_hsa002402.45834109
16Ribosome_Homo sapiens_hsa030102.24368324
17One carbon pool by folate_Homo sapiens_hsa006702.18925903
18RNA degradation_Homo sapiens_hsa030182.11519014
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.11069274
20Non-homologous end-joining_Homo sapiens_hsa034501.95357465
21mRNA surveillance pathway_Homo sapiens_hsa030151.85166091
22* p53 signaling pathway_Homo sapiens_hsa041151.83637245
23* Oocyte meiosis_Homo sapiens_hsa041141.66344687
24Purine metabolism_Homo sapiens_hsa002301.46018531
25* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.45085153
26Pyruvate metabolism_Homo sapiens_hsa006201.36572121
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.33445160
28Epstein-Barr virus infection_Homo sapiens_hsa051691.27436540
29Parkinsons disease_Homo sapiens_hsa050121.25109757
30Folate biosynthesis_Homo sapiens_hsa007901.16113900
31Oxidative phosphorylation_Homo sapiens_hsa001901.12841318
32Fatty acid elongation_Homo sapiens_hsa000621.09188496
33Steroid biosynthesis_Homo sapiens_hsa001001.07728931
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.03508095
35Systemic lupus erythematosus_Homo sapiens_hsa053220.97326342
36Propanoate metabolism_Homo sapiens_hsa006400.93992361
37Biosynthesis of amino acids_Homo sapiens_hsa012300.90534469
38Viral carcinogenesis_Homo sapiens_hsa052030.90038290
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89839906
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88872317
41Pentose phosphate pathway_Homo sapiens_hsa000300.87589265
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84898691
43Herpes simplex infection_Homo sapiens_hsa051680.75514073
44Drug metabolism - other enzymes_Homo sapiens_hsa009830.74698801
45MicroRNAs in cancer_Homo sapiens_hsa052060.73476984
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72748507
47Regulation of autophagy_Homo sapiens_hsa041400.72236162
48Selenocompound metabolism_Homo sapiens_hsa004500.71473555
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70566307
50HTLV-I infection_Homo sapiens_hsa051660.66949180
51N-Glycan biosynthesis_Homo sapiens_hsa005100.64010787
52Alzheimers disease_Homo sapiens_hsa050100.60887144
53Antigen processing and presentation_Homo sapiens_hsa046120.56965681
54Small cell lung cancer_Homo sapiens_hsa052220.56571195
55Hippo signaling pathway_Homo sapiens_hsa043900.53495244
56TGF-beta signaling pathway_Homo sapiens_hsa043500.52952493
57Thyroid cancer_Homo sapiens_hsa052160.51461842
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50758511
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49858802
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49312188
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45278911
62Glutathione metabolism_Homo sapiens_hsa004800.44272655
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.44188802
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43569457
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39483136
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38479391
67Sulfur relay system_Homo sapiens_hsa041220.38330422
68Carbon metabolism_Homo sapiens_hsa012000.37385681
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37383591
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.36327511
71Lysine degradation_Homo sapiens_hsa003100.36059393
72Vitamin digestion and absorption_Homo sapiens_hsa049770.33493859
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33444529
74Hedgehog signaling pathway_Homo sapiens_hsa043400.33202673
75Colorectal cancer_Homo sapiens_hsa052100.33070494
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.32530321
77Basal cell carcinoma_Homo sapiens_hsa052170.31354164
78Fructose and mannose metabolism_Homo sapiens_hsa000510.29483565
79Apoptosis_Homo sapiens_hsa042100.28996527
80Huntingtons disease_Homo sapiens_hsa050160.28833943
81Sulfur metabolism_Homo sapiens_hsa009200.27392336
82Fatty acid metabolism_Homo sapiens_hsa012120.25586488
83mTOR signaling pathway_Homo sapiens_hsa041500.25534052
84Circadian rhythm_Homo sapiens_hsa047100.25009033
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24868806
86Alcoholism_Homo sapiens_hsa050340.24305706
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.23256306
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22444502
89Galactose metabolism_Homo sapiens_hsa000520.21941236
90Metabolic pathways_Homo sapiens_hsa011000.21873671
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21008814
92Legionellosis_Homo sapiens_hsa051340.20227221
93Hepatitis B_Homo sapiens_hsa051610.19601841
94Protein export_Homo sapiens_hsa030600.19269375
95HIF-1 signaling pathway_Homo sapiens_hsa040660.18801190
96Notch signaling pathway_Homo sapiens_hsa043300.18619459
97* FoxO signaling pathway_Homo sapiens_hsa040680.18491565
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18323262
99Pathways in cancer_Homo sapiens_hsa052000.17738363
100Linoleic acid metabolism_Homo sapiens_hsa005910.17277044
101Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.17128692
102Arachidonic acid metabolism_Homo sapiens_hsa005900.16629535
103Prostate cancer_Homo sapiens_hsa052150.16362396
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.15494212
105Bladder cancer_Homo sapiens_hsa052190.13967571
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.12760347
107Adherens junction_Homo sapiens_hsa045200.12616841
108Tight junction_Homo sapiens_hsa045300.12147270
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.11141277
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.09761870
111Influenza A_Homo sapiens_hsa051640.09611164
112Arginine and proline metabolism_Homo sapiens_hsa003300.07729197
113Arginine biosynthesis_Homo sapiens_hsa002200.07535493
114Renin-angiotensin system_Homo sapiens_hsa046140.07352376
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.07036091
116Shigellosis_Homo sapiens_hsa051310.05796782
117beta-Alanine metabolism_Homo sapiens_hsa004100.05108320
118Cardiac muscle contraction_Homo sapiens_hsa042600.05098523
119Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.04950424
120Chronic myeloid leukemia_Homo sapiens_hsa052200.04717116
121Pancreatic cancer_Homo sapiens_hsa052120.03801333
122Wnt signaling pathway_Homo sapiens_hsa043100.03792356
123NF-kappa B signaling pathway_Homo sapiens_hsa040640.03767359
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.03642894

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