CCNB1IP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2)/M. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.36496642
2mitotic metaphase plate congression (GO:0007080)5.91541973
3viral transcription (GO:0019083)5.44258039
4translational termination (GO:0006415)5.35562148
5purine nucleobase biosynthetic process (GO:0009113)5.07938500
6DNA replication checkpoint (GO:0000076)5.01492972
7protein K6-linked ubiquitination (GO:0085020)4.83638913
8ribosome biogenesis (GO:0042254)4.81944081
9metaphase plate congression (GO:0051310)4.81501822
10ribosome assembly (GO:0042255)4.80955785
11nucleobase biosynthetic process (GO:0046112)4.76141938
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.66312054
13cotranslational protein targeting to membrane (GO:0006613)4.58879380
14protein targeting to ER (GO:0045047)4.50167385
15translational elongation (GO:0006414)4.48054013
16ribosomal small subunit biogenesis (GO:0042274)4.40361547
17establishment of protein localization to endoplasmic reticulum (GO:0072599)4.37149138
18regulation of spindle organization (GO:0090224)4.35404229
19ribosomal large subunit biogenesis (GO:0042273)4.32104035
20protein localization to kinetochore (GO:0034501)4.31522404
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.28745598
22DNA replication initiation (GO:0006270)4.28575209
23nuclear pore organization (GO:0006999)4.24164865
24protein localization to endoplasmic reticulum (GO:0070972)4.22268200
25chromatin remodeling at centromere (GO:0031055)4.14308220
26translational initiation (GO:0006413)4.13889388
27CENP-A containing nucleosome assembly (GO:0034080)4.09937746
28establishment of chromosome localization (GO:0051303)4.07293223
29cellular protein complex disassembly (GO:0043624)4.04574473
30protein localization to chromosome, centromeric region (GO:0071459)3.96660635
31mitotic nuclear envelope disassembly (GO:0007077)3.93468478
32viral life cycle (GO:0019058)3.92199477
33formation of translation preinitiation complex (GO:0001731)3.91873813
34nuclear pore complex assembly (GO:0051292)3.90218029
35regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.89849168
36regulation of nuclear cell cycle DNA replication (GO:0033262)3.89380947
37regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.89343925
38positive regulation of chromosome segregation (GO:0051984)3.87869421
39regulation of mitotic spindle organization (GO:0060236)3.87407851
40rRNA modification (GO:0000154)3.83628255
41histone exchange (GO:0043486)3.81947056
42regulation of double-strand break repair via homologous recombination (GO:0010569)3.79260319
43attachment of spindle microtubules to kinetochore (GO:0008608)3.78998486
44IMP biosynthetic process (GO:0006188)3.77590587
45kinetochore assembly (GO:0051382)3.74946467
46maturation of 5.8S rRNA (GO:0000460)3.71113330
47DNA replication-dependent nucleosome organization (GO:0034723)3.70923322
48DNA replication-dependent nucleosome assembly (GO:0006335)3.70923322
49synaptonemal complex assembly (GO:0007130)3.70416026
50mitotic sister chromatid segregation (GO:0000070)3.69420837
51kinetochore organization (GO:0051383)3.68809622
52ribonucleoprotein complex biogenesis (GO:0022613)3.68407772
53DNA replication-independent nucleosome organization (GO:0034724)3.67033743
54DNA replication-independent nucleosome assembly (GO:0006336)3.67033743
55nuclear envelope disassembly (GO:0051081)3.66894929
56membrane disassembly (GO:0030397)3.66894929
57protein complex disassembly (GO:0043241)3.65821617
58spindle checkpoint (GO:0031577)3.64844198
59transcription from RNA polymerase I promoter (GO:0006360)3.64268560
60termination of RNA polymerase I transcription (GO:0006363)3.63076869
61maturation of SSU-rRNA (GO:0030490)3.61804448
62regulation of posttranscriptional gene silencing (GO:0060147)3.61469422
63regulation of gene silencing by miRNA (GO:0060964)3.61469422
64regulation of gene silencing by RNA (GO:0060966)3.61469422
65transcription elongation from RNA polymerase I promoter (GO:0006362)3.59201491
66regulation of chromosome segregation (GO:0051983)3.54080035
67L-serine metabolic process (GO:0006563)3.53772211
68negative regulation of chromosome segregation (GO:0051985)3.52746901
69regulation of telomere maintenance via telomerase (GO:0032210)3.52120682
70macromolecular complex disassembly (GO:0032984)3.49776467
71transcription initiation from RNA polymerase I promoter (GO:0006361)3.48831565
72DNA strand elongation involved in DNA replication (GO:0006271)3.48026702
73negative regulation of mitotic sister chromatid separation (GO:2000816)3.46516771
74negative regulation of mitotic sister chromatid segregation (GO:0033048)3.46516771
75negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.46516771
76negative regulation of sister chromatid segregation (GO:0033046)3.46516771
77mitotic spindle checkpoint (GO:0071174)3.45762369
78regulation of mitotic metaphase/anaphase transition (GO:0030071)3.45052625
79spliceosomal snRNP assembly (GO:0000387)3.42552724
80regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.39616020
81negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.39438102
82nuclear-transcribed mRNA catabolic process (GO:0000956)3.38107691
83piRNA metabolic process (GO:0034587)3.37839826
84mitotic spindle assembly checkpoint (GO:0007094)3.34834051
85meiotic chromosome segregation (GO:0045132)3.34756128
86spindle assembly checkpoint (GO:0071173)3.32055613
87regulation of centrosome cycle (GO:0046605)3.31569194
88synaptonemal complex organization (GO:0070193)3.30303882
89folic acid metabolic process (GO:0046655)3.29672866
90rRNA processing (GO:0006364)3.29119127
91regulation of helicase activity (GO:0051095)3.28940994
92DNA strand elongation (GO:0022616)3.28669894
937-methylguanosine mRNA capping (GO:0006370)3.28478608
94regulation of sister chromatid segregation (GO:0033045)3.27036335
95regulation of mitotic sister chromatid separation (GO:0010965)3.27036335
96regulation of mitotic sister chromatid segregation (GO:0033047)3.27036335
97protein localization to chromosome (GO:0034502)3.26265997
98IMP metabolic process (GO:0046040)3.24182029
99translation (GO:0006412)3.23599710
100transcription elongation from RNA polymerase III promoter (GO:0006385)3.23377347
101termination of RNA polymerase III transcription (GO:0006386)3.23377347
1027-methylguanosine RNA capping (GO:0009452)3.22770671
103RNA capping (GO:0036260)3.22770671
104establishment of protein localization to mitochondrial membrane (GO:0090151)3.22716728
105mRNA catabolic process (GO:0006402)3.21852738
106rRNA metabolic process (GO:0016072)3.20628413
107somatic diversification of immune receptors via somatic mutation (GO:0002566)3.19619874
108somatic hypermutation of immunoglobulin genes (GO:0016446)3.19619874
109regulation of centriole replication (GO:0046599)3.18314500
110mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.15493784
111telomere maintenance via semi-conservative replication (GO:0032201)3.12956136
112heterochromatin organization (GO:0070828)3.12781955
113regulation of meiosis I (GO:0060631)3.12459219
114rRNA methylation (GO:0031167)3.11627920
115paraxial mesoderm development (GO:0048339)3.10898755
116sister chromatid segregation (GO:0000819)3.09746003
117chromosome segregation (GO:0007059)3.08851455
118histone H2A monoubiquitination (GO:0035518)3.08071169
119inner cell mass cell proliferation (GO:0001833)3.06734211
120protein targeting to membrane (GO:0006612)3.06694434
121positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.06458217
122positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.06458217
123positive regulation of mitotic sister chromatid separation (GO:1901970)3.06458217
124transcription-coupled nucleotide-excision repair (GO:0006283)3.05982220
125ATP synthesis coupled proton transport (GO:0015986)3.05763881
126energy coupled proton transport, down electrochemical gradient (GO:0015985)3.05763881
127establishment of integrated proviral latency (GO:0075713)3.04931235
128RNA catabolic process (GO:0006401)2.98994626
129exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.98690846
130synapsis (GO:0007129)2.97803486
131nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.96938945
132non-recombinational repair (GO:0000726)2.92515754
133double-strand break repair via nonhomologous end joining (GO:0006303)2.92515754
134replication fork processing (GO:0031297)2.90076329
135cellular component biogenesis (GO:0044085)2.78240992
136chaperone-mediated protein transport (GO:0072321)2.71852161
137serine family amino acid biosynthetic process (GO:0009070)2.65913842
138peptidyl-arginine omega-N-methylation (GO:0035247)2.65005959
139histone arginine methylation (GO:0034969)2.63798873
140DNA strand renaturation (GO:0000733)2.62845908
141telomere maintenance via recombination (GO:0000722)2.60725239
142nucleotide-excision repair, DNA gap filling (GO:0006297)2.59233863
143mitotic recombination (GO:0006312)2.58998489
144regulation of mitochondrial translation (GO:0070129)2.57734496
145DNA damage response, detection of DNA damage (GO:0042769)2.57598054
146DNA ligation (GO:0006266)2.56614111
147regulation of mitotic spindle checkpoint (GO:1903504)2.54173653
148regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.54173653
149lysine metabolic process (GO:0006553)2.53946976
150lysine catabolic process (GO:0006554)2.53946976
151resolution of meiotic recombination intermediates (GO:0000712)2.52728413
152DNA unwinding involved in DNA replication (GO:0006268)2.50269342
153negative regulation of DNA-dependent DNA replication (GO:2000104)2.49166553
154glycine metabolic process (GO:0006544)2.48120310
155homocysteine metabolic process (GO:0050667)2.43052039
156peptidyl-arginine N-methylation (GO:0035246)2.42034856
157peptidyl-arginine methylation (GO:0018216)2.42034856
158maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.37865676
159oxidative phosphorylation (GO:0006119)2.37179622
160pre-miRNA processing (GO:0031054)2.36054853

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.56734878
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.46585544
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.11090902
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.01221171
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.55231923
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.25376388
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.18441619
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.04743164
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.95677467
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.80825293
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.79481076
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.77445850
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.71754029
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.68363187
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.64475520
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.58116404
17KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.51248937
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.51248937
19KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.51248937
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.47809102
21AR_21909140_ChIP-Seq_LNCAP_Human2.46667096
22KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.40255108
23NANOG_18555785_ChIP-Seq_MESCs_Mouse2.39374762
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35184318
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.32720650
26POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.23279379
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.17865574
28SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.17110911
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.12022451
30SALL1_21062744_ChIP-ChIP_HESCs_Human2.07776483
31ZNF274_21170338_ChIP-Seq_K562_Hela2.04918807
32XRN2_22483619_ChIP-Seq_HELA_Human2.04844979
33MYCN_18555785_ChIP-Seq_MESCs_Mouse2.04414732
34VDR_23849224_ChIP-Seq_CD4+_Human2.01183948
35MYC_18940864_ChIP-ChIP_HL60_Human1.99064823
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.98722026
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.96586384
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.90877888
39NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.87489860
40NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.86023691
41* E2F1_21310950_ChIP-Seq_MCF-7_Human1.80410099
42POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.78216343
43DCP1A_22483619_ChIP-Seq_HELA_Human1.77189101
44STAT3_1855785_ChIP-Seq_MESCs_Mouse1.76560448
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.75737458
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.72087581
47SOX2_16153702_ChIP-ChIP_HESCs_Human1.71362979
48GABP_19822575_ChIP-Seq_HepG2_Human1.69550884
49FUS_26573619_Chip-Seq_HEK293_Human1.64273741
50* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61927684
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.61768194
52FOXP3_21729870_ChIP-Seq_TREG_Human1.60740790
53NANOG_16153702_ChIP-ChIP_HESCs_Human1.60683300
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.58257004
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.57943319
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56443571
57THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55723286
58SOX2_18555785_ChIP-Seq_MESCs_Mouse1.55021191
59EWS_26573619_Chip-Seq_HEK293_Human1.53671539
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52901937
61TTF2_22483619_ChIP-Seq_HELA_Human1.52308111
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.50838861
63IRF1_19129219_ChIP-ChIP_H3396_Human1.49231482
64TCF3_18692474_ChIP-Seq_MEFs_Mouse1.48801118
65KDM5A_27292631_Chip-Seq_BREAST_Human1.41566835
66VDR_22108803_ChIP-Seq_LS180_Human1.40621991
67NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.38830945
68EZH2_22144423_ChIP-Seq_EOC_Human1.36793966
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35422697
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34668348
71TCF3_18692474_ChIP-Seq_MESCs_Mouse1.32563660
72FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30985550
73ELK1_19687146_ChIP-ChIP_HELA_Human1.30875634
74NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.30424235
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.28802649
76SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.24647916
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23893716
78ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.23074416
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.22163500
80KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19220325
81ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17940265
82KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14181176
83NANOG_21062744_ChIP-ChIP_HESCs_Human1.13837295
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12477869
85SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.11879876
86SRF_21415370_ChIP-Seq_HL-1_Mouse1.11305244
87SOX2_18692474_ChIP-Seq_MEFs_Mouse1.09840978
88NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06701516
89NANOG_18692474_ChIP-Seq_MEFs_Mouse1.03794797
90DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02780324
91NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01512401
92CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00881410
93SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00209064
94SOX2_18692474_ChIP-Seq_MESCs_Mouse0.99916130
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99863551
96NOTCH1_21737748_ChIP-Seq_TLL_Human0.99724593
97KAP1_22055183_ChIP-Seq_ESCs_Mouse0.99658160
98ZNF263_19887448_ChIP-Seq_K562_Human0.99421931
99POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.98605351
100TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98525046
101CIITA_25753668_ChIP-Seq_RAJI_Human0.98287148
102SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97188141
103TFEB_21752829_ChIP-Seq_HELA_Human0.96202060
104NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.94970649
105OCT4_18692474_ChIP-Seq_MEFs_Mouse0.93553201
106ELF1_17652178_ChIP-ChIP_JURKAT_Human0.93438651
107NANOG_18692474_ChIP-Seq_MESCs_Mouse0.93266959
108BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92869136
109KAP1_27257070_Chip-Seq_ESCs_Mouse0.92025212
110ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.91821494
111RBPJ_22232070_ChIP-Seq_NCS_Mouse0.91637295
112E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91604682
113HOXB4_20404135_ChIP-ChIP_EML_Mouse0.90843948
114CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90506286
115DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89782260
116GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.87181237
117IGF1R_20145208_ChIP-Seq_DFB_Human0.86424696
118FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.85270484
119P300_19829295_ChIP-Seq_ESCs_Human0.81584324
120FLI1_27457419_Chip-Seq_LIVER_Mouse0.80102101
121RNF2_27304074_Chip-Seq_NSC_Mouse0.79880957
122HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.79747184
123CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.78869675
124EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.76857798
125CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.76700706
126GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.74230417
127SOX17_20123909_ChIP-Seq_XEN_Mouse0.74172552
128TP53_22573176_ChIP-Seq_HFKS_Human0.73526960
129MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.72044706

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.27157299
2MP0003111_abnormal_nucleus_morphology4.86396211
3MP0004957_abnormal_blastocyst_morpholog4.69575883
4MP0010094_abnormal_chromosome_stability4.54394318
5MP0008057_abnormal_DNA_replication4.24489793
6MP0003077_abnormal_cell_cycle4.04889880
7MP0008058_abnormal_DNA_repair3.67733292
8MP0003718_maternal_effect3.45653229
9MP0009379_abnormal_foot_pigmentation3.28258718
10MP0008877_abnormal_DNA_methylation2.91512121
11MP0003941_abnormal_skin_development2.74699606
12MP0008007_abnormal_cellular_replicative2.74240902
13MP0003786_premature_aging2.73453653
14MP0001730_embryonic_growth_arrest2.63565080
15MP0008932_abnormal_embryonic_tissue2.62841186
16MP0002938_white_spotting2.41213401
17MP0003123_paternal_imprinting2.38912628
18MP0000350_abnormal_cell_proliferation2.31230544
19MP0010030_abnormal_orbit_morphology2.27254467
20MP0003122_maternal_imprinting2.21141129
21MP0006292_abnormal_olfactory_placode2.15263833
22MP0005380_embryogenesis_phenotype1.97965739
23MP0001672_abnormal_embryogenesis/_devel1.97965739
24* MP0002210_abnormal_sex_determination1.92169454
25MP0010307_abnormal_tumor_latency1.88618707
26MP0002085_abnormal_embryonic_tissue1.74145282
27MP0003806_abnormal_nucleotide_metabolis1.73965391
28MP0001697_abnormal_embryo_size1.68131207
29MP0002234_abnormal_pharynx_morphology1.66778345
30MP0010352_gastrointestinal_tract_polyps1.64422613
31* MP0001145_abnormal_male_reproductive1.63952219
32* MP0001929_abnormal_gametogenesis1.62715001
33MP0002084_abnormal_developmental_patter1.62316008
34MP0003984_embryonic_growth_retardation1.61627541
35MP0002653_abnormal_ependyma_morphology1.59205489
36MP0002088_abnormal_embryonic_growth/wei1.58308738
37MP0008789_abnormal_olfactory_epithelium1.58302380
38MP0001529_abnormal_vocalization1.56365314
39MP0003315_abnormal_perineum_morphology1.55323675
40MP0002080_prenatal_lethality1.55284420
41MP0002233_abnormal_nose_morphology1.54966904
42MP0005394_taste/olfaction_phenotype1.52733014
43MP0005499_abnormal_olfactory_system1.52733014
44MP0002086_abnormal_extraembryonic_tissu1.49899298
45MP0001293_anophthalmia1.48742741
46* MP0000653_abnormal_sex_gland1.48407165
47MP0002697_abnormal_eye_size1.46354512
48MP0004197_abnormal_fetal_growth/weight/1.46070077
49MP0002102_abnormal_ear_morphology1.43882926
50MP0003646_muscle_fatigue1.36033840
51MP0009697_abnormal_copulation1.35478592
52MP0000049_abnormal_middle_ear1.35151784
53MP0000631_abnormal_neuroendocrine_gland1.29703041
54MP0000313_abnormal_cell_death1.29604103
55MP0008995_early_reproductive_senescence1.28262828
56MP0005395_other_phenotype1.25548730
57MP0003283_abnormal_digestive_organ1.20238897
58MP0006072_abnormal_retinal_apoptosis1.20231003
59MP0000566_synostosis1.18471970
60MP0002396_abnormal_hematopoietic_system1.18055887
61MP0003136_yellow_coat_color1.17334116
62MP0003890_abnormal_embryonic-extraembry1.17226359
63MP0002751_abnormal_autonomic_nervous1.16906458
64MP0002837_dystrophic_cardiac_calcinosis1.15333701
65MP0000537_abnormal_urethra_morphology1.14309107
66MP0003121_genomic_imprinting1.12619535
67MP0003119_abnormal_digestive_system1.12151539
68MP0004264_abnormal_extraembryonic_tissu1.11000068
69* MP0001119_abnormal_female_reproductive1.09326359
70MP0003937_abnormal_limbs/digits/tail_de1.08624819
71MP0003942_abnormal_urinary_system1.08130540
72MP0002019_abnormal_tumor_incidence1.08030758
73MP0002163_abnormal_gland_morphology1.06611176
74MP0003698_abnormal_male_reproductive1.06245421
75MP0008260_abnormal_autophagy1.05356265
76MP0003567_abnormal_fetal_cardiomyocyte1.02822317
77MP0003755_abnormal_palate_morphology1.01308886
78MP0006035_abnormal_mitochondrial_morpho1.01094769
79MP0003699_abnormal_female_reproductive0.99607595
80MP0003705_abnormal_hypodermis_morpholog0.98407445
81MP0000778_abnormal_nervous_system0.98223659
82MP0003186_abnormal_redox_activity0.95299341
83MP0001984_abnormal_olfaction0.95080124
84MP0004133_heterotaxia0.94922523
85MP0005076_abnormal_cell_differentiation0.93268292
86MP0005389_reproductive_system_phenotype0.91827677
87MP0000372_irregular_coat_pigmentation0.91608369
88MP0002111_abnormal_tail_morphology0.88103092
89MP0005391_vision/eye_phenotype0.87928101
90* MP0002161_abnormal_fertility/fecundity0.87062551
91MP0005377_hearing/vestibular/ear_phenot0.86736357
92MP0003878_abnormal_ear_physiology0.86736357
93MP0006276_abnormal_autonomic_nervous0.86682659
94MP0002254_reproductive_system_inflammat0.86672052
95MP0000490_abnormal_crypts_of0.86653732
96MP0005367_renal/urinary_system_phenotyp0.86339707
97MP0000516_abnormal_urinary_system0.86339707
98MP0001286_abnormal_eye_development0.85108061
99MP0009672_abnormal_birth_weight0.84632315
100MP0001299_abnormal_eye_distance/0.84304742
101MP0002160_abnormal_reproductive_system0.82508556
102MP0005451_abnormal_body_composition0.82425328
103MP0005551_abnormal_eye_electrophysiolog0.81071450
104MP0003936_abnormal_reproductive_system0.79693998
105MP0003385_abnormal_body_wall0.78944346
106MP0005621_abnormal_cell_physiology0.78344580
107MP0009703_decreased_birth_body0.78158540
108MP0005253_abnormal_eye_physiology0.75602702
109MP0005384_cellular_phenotype0.75337864
110MP0005187_abnormal_penis_morphology0.74734883
111MP0000647_abnormal_sebaceous_gland0.74691957
112MP0003950_abnormal_plasma_membrane0.72726099
113MP0000627_abnormal_mammary_gland0.72503771
114MP0003938_abnormal_ear_development0.72179378
115MP0004147_increased_porphyrin_level0.71879918
116MP0003880_abnormal_central_pattern0.71810546
117MP0003566_abnormal_cell_adhesion0.70952231
118MP0003221_abnormal_cardiomyocyte_apopto0.68921401
119MP0002092_abnormal_eye_morphology0.68799661
120MP0005195_abnormal_posterior_eye0.67375669
121MP0001919_abnormal_reproductive_system0.66892210
122MP0001188_hyperpigmentation0.66420299
123MP0003935_abnormal_craniofacial_develop0.66170395
124MP0002116_abnormal_craniofacial_bone0.65963181
125MP0005266_abnormal_metabolism0.65872464
126MP0000432_abnormal_head_morphology0.61464039
127MP0003861_abnormal_nervous_system0.61072599
128MP0000428_abnormal_craniofacial_morphol0.58506740
129MP0000750_abnormal_muscle_regeneration0.58162012
130MP0000358_abnormal_cell_content/0.57868239
131MP0003448_altered_tumor_morphology0.56789489
132MP0009053_abnormal_anal_canal0.55859738
133MP0001346_abnormal_lacrimal_gland0.55021431
134MP0003787_abnormal_imprinting0.53639926
135MP0002269_muscular_atrophy0.53090315
136MP0009333_abnormal_splenocyte_physiolog0.52999301
137MP0005501_abnormal_skin_physiology0.52999176
138MP0001661_extended_life_span0.52430974
139MP0000427_abnormal_hair_cycle0.51195610
140MP0001485_abnormal_pinna_reflex0.50652346
141MP0002132_abnormal_respiratory_system0.50026218
142MP0001849_ear_inflammation0.49604026
143MP0002277_abnormal_respiratory_mucosa0.49370828

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.87050351
2Breast hypoplasia (HP:0003187)5.95568988
3Abnormality of the labia minora (HP:0012880)5.12855623
4Impulsivity (HP:0100710)4.44200106
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.40290058
6Carpal bone hypoplasia (HP:0001498)4.37827146
7Chromsome breakage (HP:0040012)4.34751222
8Patellar aplasia (HP:0006443)4.25895300
9Aplasia/Hypoplasia of the patella (HP:0006498)4.07857519
10Abnormality of cells of the erythroid lineage (HP:0012130)3.95123058
11Absent radius (HP:0003974)3.70628837
12Abnormal number of erythroid precursors (HP:0012131)3.56579820
13Degeneration of anterior horn cells (HP:0002398)3.48734406
14Abnormality of the anterior horn cell (HP:0006802)3.48734406
15Aplasia involving forearm bones (HP:0009822)3.48684720
16Absent forearm bone (HP:0003953)3.48684720
17Cerebral hypomyelination (HP:0006808)3.36239217
18Rough bone trabeculation (HP:0100670)3.34535563
19Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.33554291
20Abnormal spermatogenesis (HP:0008669)3.27775351
21Meckel diverticulum (HP:0002245)3.27165164
22Hyperglycinemia (HP:0002154)3.20098196
23Supernumerary spleens (HP:0009799)3.17899846
24Ependymoma (HP:0002888)3.17232499
25Abnormality of the preputium (HP:0100587)3.15526752
26Azoospermia (HP:0000027)3.13249669
27Septo-optic dysplasia (HP:0100842)3.09230117
28Abnormality of the ileum (HP:0001549)3.06401432
29Macrocytic anemia (HP:0001972)3.05102477
30Abnormality of chromosome stability (HP:0003220)3.03836241
31Aplasia/Hypoplasia involving the musculature (HP:0001460)2.93548437
32Oral leukoplakia (HP:0002745)2.91737631
33Hyperglycinuria (HP:0003108)2.86131669
34Medulloblastoma (HP:0002885)2.85927205
35Selective tooth agenesis (HP:0001592)2.81819239
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.76603264
37Rhabdomyosarcoma (HP:0002859)2.72362907
38Horseshoe kidney (HP:0000085)2.67614776
39Absent thumb (HP:0009777)2.67384479
40Breast aplasia (HP:0100783)2.62844079
41Abnormal trabecular bone morphology (HP:0100671)2.61003107
42Ureteral duplication (HP:0000073)2.58091693
43Agnosia (HP:0010524)2.54844453
44Aplasia/hypoplasia of the humerus (HP:0006507)2.51642329
45Facial hemangioma (HP:0000329)2.51219257
46Pancreatic cysts (HP:0001737)2.50295303
47Rib fusion (HP:0000902)2.46626835
48Aplasia/Hypoplasia of the breasts (HP:0010311)2.45959567
49Pancreatic fibrosis (HP:0100732)2.44917228
50Bone marrow hypocellularity (HP:0005528)2.43428057
51Premature graying of hair (HP:0002216)2.42699456
52Neoplasm of the oral cavity (HP:0100649)2.41945665
53Squamous cell carcinoma (HP:0002860)2.41174054
54Rectovaginal fistula (HP:0000143)2.39433928
55Rectal fistula (HP:0100590)2.39433928
56Premature ovarian failure (HP:0008209)2.38841676
57Ectopic kidney (HP:0000086)2.37358361
58Duodenal stenosis (HP:0100867)2.37092633
59Small intestinal stenosis (HP:0012848)2.37092633
60Neoplasm of the pancreas (HP:0002894)2.36379452
61Duplicated collecting system (HP:0000081)2.36044955
62Acute encephalopathy (HP:0006846)2.35045057
63Methylmalonic aciduria (HP:0012120)2.34688450
64Acute necrotizing encephalopathy (HP:0006965)2.31555944
65Intestinal atresia (HP:0011100)2.31146069
66Secondary amenorrhea (HP:0000869)2.30376951
67CNS hypomyelination (HP:0003429)2.29570236
68Stenosis of the external auditory canal (HP:0000402)2.28513505
69Optic nerve hypoplasia (HP:0000609)2.27640131
70Anophthalmia (HP:0000528)2.24593396
71Aplasia/Hypoplasia of the sternum (HP:0006714)2.24200870
72Colon cancer (HP:0003003)2.24175431
73Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.24049092
74Bilateral microphthalmos (HP:0007633)2.23936977
75Microretrognathia (HP:0000308)2.23111345
76Progressive muscle weakness (HP:0003323)2.22443465
77Increased hepatocellular lipid droplets (HP:0006565)2.19660004
78Absent septum pellucidum (HP:0001331)2.17980482
79Multiple enchondromatosis (HP:0005701)2.16612429
80Shawl scrotum (HP:0000049)2.16424123
81Abnormal biliary tract physiology (HP:0012439)2.15667081
82Bile duct proliferation (HP:0001408)2.15667081
83Pallor (HP:0000980)2.15469387
84Basal cell carcinoma (HP:0002671)2.15147113
85Reticulocytopenia (HP:0001896)2.12372709
86Lipid accumulation in hepatocytes (HP:0006561)2.11603963
87Short thumb (HP:0009778)2.11363845
88Sloping forehead (HP:0000340)2.10791834
89Abnormality of serine family amino acid metabolism (HP:0010894)2.10778766
90Abnormality of glycine metabolism (HP:0010895)2.10778766
91Tracheoesophageal fistula (HP:0002575)2.09109120
92Atresia of the external auditory canal (HP:0000413)2.07686888
93Atrophy/Degeneration involving motor neurons (HP:0007373)2.06597262
94Glioma (HP:0009733)2.06197424
95Astrocytoma (HP:0009592)2.03880230
96Abnormality of the astrocytes (HP:0100707)2.03880230
97True hermaphroditism (HP:0010459)2.03383023
98Abnormal number of incisors (HP:0011064)2.02893448
99Myelodysplasia (HP:0002863)2.02616971
100Triphalangeal thumb (HP:0001199)2.00941438
101Fused cervical vertebrae (HP:0002949)2.00725993
102Adrenal hypoplasia (HP:0000835)2.00589496
103Abnormality of pyrimidine metabolism (HP:0004353)1.99958261
104Abnormality of the duodenum (HP:0002246)1.97975873
105Intestinal fistula (HP:0100819)1.97489281
106Bifid tongue (HP:0010297)1.96732472
107Sclerocornea (HP:0000647)1.95122791
108Abnormal mitochondria in muscle tissue (HP:0008316)1.93814456
109Abnormality of the renal collecting system (HP:0004742)1.93738715
110Abnormality of serum amino acid levels (HP:0003112)1.93552610
111Trismus (HP:0000211)1.93423317
112Short humerus (HP:0005792)1.92729078
113Hepatoblastoma (HP:0002884)1.92644442
114Megaloblastic anemia (HP:0001889)1.92521162
115Nephroblastoma (Wilms tumor) (HP:0002667)1.92054787
116Molar tooth sign on MRI (HP:0002419)1.92053468
117Abnormality of midbrain morphology (HP:0002418)1.92053468
118Increased CSF lactate (HP:0002490)1.91494094
119Aplasia/Hypoplasia of the sacrum (HP:0008517)1.91450228
120Vaginal fistula (HP:0004320)1.91333929
121Hyperventilation (HP:0002883)1.89356635
122Esophageal atresia (HP:0002032)1.89185719
123Neoplasm of striated muscle (HP:0009728)1.88633341
124Pendular nystagmus (HP:0012043)1.87949479
125Oligodactyly (HP:0012165)1.87690447
126Depressed nasal ridge (HP:0000457)1.86587727
127Medial flaring of the eyebrow (HP:0010747)1.85981266
128Abnormality of cochlea (HP:0000375)1.85751394
129Facial cleft (HP:0002006)1.83668059
130Nephronophthisis (HP:0000090)1.82897466
131Maternal diabetes (HP:0009800)1.81858409
132Oligodactyly (hands) (HP:0001180)1.81733163
133Breech presentation (HP:0001623)1.81567340
134Slender long bone (HP:0003100)1.81342120
135Cellular immunodeficiency (HP:0005374)1.81002126
136Gastrointestinal atresia (HP:0002589)1.80994421
137Abnormality of the septum pellucidum (HP:0007375)1.80319307
138Morphological abnormality of the inner ear (HP:0011390)1.78494986
139Abnormal lung lobation (HP:0002101)1.78026448
140Biliary tract neoplasm (HP:0100574)1.77825182
141Embryonal renal neoplasm (HP:0011794)1.76619527
142Clubbing of toes (HP:0100760)1.76429686
143Vaginal atresia (HP:0000148)1.75949474
144Dandy-Walker malformation (HP:0001305)1.75045960
145Mitochondrial inheritance (HP:0001427)1.75030998
146Progressive macrocephaly (HP:0004481)1.71970923
147Genital tract atresia (HP:0001827)1.70752024
148Congenital primary aphakia (HP:0007707)1.70564167
149Anencephaly (HP:0002323)1.70463937
150Neoplasm of the adrenal cortex (HP:0100641)1.68738923
151Abnormality of the carotid arteries (HP:0005344)1.68575525
152Cerebral edema (HP:0002181)1.67823057
153Cerebellar dysplasia (HP:0007033)1.66676669
154High anterior hairline (HP:0009890)1.66338090
155Hyperalaninemia (HP:0003348)1.66066121
156Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.66066121
157Abnormality of alanine metabolism (HP:0010916)1.66066121
158Preaxial hand polydactyly (HP:0001177)1.65831730
159Cystic liver disease (HP:0006706)1.63761557
160Aplasia/Hypoplasia of the spleen (HP:0010451)1.60874694
161Abnormality of the renal medulla (HP:0100957)1.60240066
162Pancreatic islet-cell hyperplasia (HP:0004510)1.59269654
163Increased serum lactate (HP:0002151)1.58978168
164Gait imbalance (HP:0002141)1.58834152
165Nephrogenic diabetes insipidus (HP:0009806)1.57372538
166Hypoplastic pelvis (HP:0008839)1.56174708

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.76381563
2BUB14.23066795
3EPHA23.51073537
4CDC73.40765624
5SRPK13.26081131
6CDK193.13474979
7EIF2AK13.01933891
8VRK22.92101870
9TTK2.85726231
10CDK122.78181529
11NEK22.77528374
12MKNK22.54710684
13PLK12.41302639
14ACVR1B2.34970370
15PLK42.34382139
16PLK32.22615244
17BRSK22.17250287
18TSSK62.15362461
19NEK12.12408469
20MKNK12.07446470
21EIF2AK31.96442858
22CHEK21.93306805
23TAF11.90819640
24STK38L1.88603775
25STK161.82604677
26WNK41.78698515
27BMPR1B1.75178687
28PNCK1.74950667
29CDK71.68338557
30DYRK31.64801275
31LATS21.59829866
32AKT31.53423741
33AURKB1.47034285
34NME21.47023957
35MAP3K41.45160086
36ALK1.44079396
37ATR1.42520389
38AURKA1.41257899
39CHEK11.39267553
40BRD41.29156881
41BRSK11.24662016
42CDK41.18536745
43ZAK1.18517260
44TNIK1.15807054
45LATS11.14286077
46BRAF1.12295988
47EIF2AK21.10080618
48STK391.10043651
49VRK11.08587821
50PDK31.08227791
51PDK41.08227791
52TGFBR11.07136194
53STK31.02750828
54MAP3K81.02179209
55MAP3K100.97839755
56ATM0.97550530
57STK40.97487213
58PDK20.94394535
59RPS6KB20.93484319
60PRKCI0.92263319
61CASK0.92138127
62CDK20.90004273
63FGFR20.88569876
64TESK20.86344527
65CSNK1G30.81000800
66CSNK1A1L0.75616939
67DYRK20.73460930
68MELK0.73031807
69CSNK1G20.72852673
70PBK0.71745244
71MAP4K20.71738302
72RPS6KA40.71695431
73GRK10.71471449
74CDK10.70369027
75EEF2K0.69279923
76CDK60.69027128
77EPHB20.69024416
78OXSR10.66957511
79TIE10.66877720
80PINK10.66087035
81CSNK2A20.65912160
82FLT30.64954884
83TRIM280.64355877
84FRK0.63762534
85CCNB10.63358653
86CSNK2A10.63094131
87EPHA40.63024523
88MST40.62302779
89BCR0.62042117
90PAK10.60409618
91FGFR10.60210531
92PIM10.58974161
93STK100.58802936
94CAMK1G0.58383659
95IRAK30.58038852
96CSNK1E0.55432437
97PASK0.55390688
98PLK20.54288037
99PRKCG0.52503599
100NEK60.49928921
101DYRK1B0.49263792
102PAK40.49051700
103MAPKAPK50.48473649
104CAMK1D0.44299785
105STK240.44122282
106INSRR0.42212472
107CAMK10.41360290
108CSNK1D0.41310988
109CDK30.40714100
110MARK30.38907222
111ARAF0.38353286
112OBSCN0.38298324
113PRKDC0.37942825
114ERBB40.36723543
115TLK10.36152851
116MTOR0.34380056
117WNK30.34249339
118DAPK30.33072406
119MAPK140.29366056
120SCYL20.28640006
121GSK3B0.26633233
122NME10.25752655
123RPS6KA50.23784458
124MAP3K90.22769871
125STK380.21743556
126MAPK100.21647522
127ABL20.20948824
128PRKAA10.19373140
129ADRBK20.18425835
130BCKDK0.16432467
131CDK80.16386960
132CSNK1G10.15612904
133MAPK10.15526658
134DYRK1A0.15440351
135MAPK80.14868187
136NUAK10.12871766
137AKT20.12848227

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030085.04370362
2RNA polymerase_Homo sapiens_hsa030204.35560808
3DNA replication_Homo sapiens_hsa030303.84040895
4RNA transport_Homo sapiens_hsa030133.74104727
5Mismatch repair_Homo sapiens_hsa034303.65694976
6Vitamin B6 metabolism_Homo sapiens_hsa007503.31874382
7Proteasome_Homo sapiens_hsa030503.28178731
8Spliceosome_Homo sapiens_hsa030403.11317464
9Basal transcription factors_Homo sapiens_hsa030223.02695023
10Homologous recombination_Homo sapiens_hsa034402.92415443
11Cell cycle_Homo sapiens_hsa041102.91837563
12Nucleotide excision repair_Homo sapiens_hsa034202.67243745
13Fanconi anemia pathway_Homo sapiens_hsa034602.59784137
14Pyrimidine metabolism_Homo sapiens_hsa002402.48295847
15One carbon pool by folate_Homo sapiens_hsa006702.35823694
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.31787997
17Base excision repair_Homo sapiens_hsa034102.24620332
18Oxidative phosphorylation_Homo sapiens_hsa001902.15336035
19Propanoate metabolism_Homo sapiens_hsa006402.15063006
20Ribosome_Homo sapiens_hsa030102.14262530
21mRNA surveillance pathway_Homo sapiens_hsa030152.14257131
22Non-homologous end-joining_Homo sapiens_hsa034502.05223031
23Parkinsons disease_Homo sapiens_hsa050122.00340522
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95076832
25Protein export_Homo sapiens_hsa030601.94741376
26RNA degradation_Homo sapiens_hsa030181.86746831
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.80782334
28p53 signaling pathway_Homo sapiens_hsa041151.77077815
29Purine metabolism_Homo sapiens_hsa002301.54184871
30Oocyte meiosis_Homo sapiens_hsa041141.43839841
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38933762
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.31866192
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.30509168
34Pyruvate metabolism_Homo sapiens_hsa006201.25298434
35Selenocompound metabolism_Homo sapiens_hsa004501.25281920
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.22652757
37Cardiac muscle contraction_Homo sapiens_hsa042601.20590914
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.16437222
39Alzheimers disease_Homo sapiens_hsa050101.14230389
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.12100509
41Epstein-Barr virus infection_Homo sapiens_hsa051691.11855142
42Butanoate metabolism_Homo sapiens_hsa006501.07847017
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.05993832
44Pentose phosphate pathway_Homo sapiens_hsa000301.00994517
45Biosynthesis of amino acids_Homo sapiens_hsa012301.00481173
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98081135
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91808653
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91270512
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.90917714
50Fatty acid elongation_Homo sapiens_hsa000620.88974058
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82660046
52Folate biosynthesis_Homo sapiens_hsa007900.81358995
53Arginine biosynthesis_Homo sapiens_hsa002200.81145140
54Regulation of autophagy_Homo sapiens_hsa041400.81076187
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78996371
56Lysine degradation_Homo sapiens_hsa003100.75837996
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.75241679
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.73534901
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71792483
60Fructose and mannose metabolism_Homo sapiens_hsa000510.71255404
61Peroxisome_Homo sapiens_hsa041460.69220141
62Phototransduction_Homo sapiens_hsa047440.67247710
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63507922
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61589508
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61071719
66Viral carcinogenesis_Homo sapiens_hsa052030.56294579
67Herpes simplex infection_Homo sapiens_hsa051680.55539281
68Glycerophospholipid metabolism_Homo sapiens_hsa005640.54855506
69Fat digestion and absorption_Homo sapiens_hsa049750.54379688
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.53144951
71Systemic lupus erythematosus_Homo sapiens_hsa053220.52882249
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52878791
73Fatty acid metabolism_Homo sapiens_hsa012120.52420436
74MicroRNAs in cancer_Homo sapiens_hsa052060.52265777
75Hippo signaling pathway_Homo sapiens_hsa043900.51022066
76Tryptophan metabolism_Homo sapiens_hsa003800.50666414
77Fatty acid degradation_Homo sapiens_hsa000710.49983620
78Retinol metabolism_Homo sapiens_hsa008300.47903922
79Glutathione metabolism_Homo sapiens_hsa004800.47126963
80Caffeine metabolism_Homo sapiens_hsa002320.44302012
81Carbon metabolism_Homo sapiens_hsa012000.43857919
82Antigen processing and presentation_Homo sapiens_hsa046120.43837176
83TGF-beta signaling pathway_Homo sapiens_hsa043500.43058048
84Linoleic acid metabolism_Homo sapiens_hsa005910.42747790
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42441592
86Arachidonic acid metabolism_Homo sapiens_hsa005900.42073169
87HTLV-I infection_Homo sapiens_hsa051660.40912673
88Arginine and proline metabolism_Homo sapiens_hsa003300.40381073
89Vitamin digestion and absorption_Homo sapiens_hsa049770.38357600
90Thyroid cancer_Homo sapiens_hsa052160.34854567
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34030045
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.33964474
93Tyrosine metabolism_Homo sapiens_hsa003500.32261925
94Hedgehog signaling pathway_Homo sapiens_hsa043400.31552929
95Metabolic pathways_Homo sapiens_hsa011000.31197182
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28985443
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28848709
98Huntingtons disease_Homo sapiens_hsa050160.28774518
99N-Glycan biosynthesis_Homo sapiens_hsa005100.27324127
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.26647568
101Steroid hormone biosynthesis_Homo sapiens_hsa001400.26211505
102Sulfur relay system_Homo sapiens_hsa041220.26136207
103Notch signaling pathway_Homo sapiens_hsa043300.25824192
104mTOR signaling pathway_Homo sapiens_hsa041500.25289090
105Tight junction_Homo sapiens_hsa045300.25273242
106Chemical carcinogenesis_Homo sapiens_hsa052040.24772910
107Nitrogen metabolism_Homo sapiens_hsa009100.24158869
108Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23412507
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23369247
110Basal cell carcinoma_Homo sapiens_hsa052170.21305430
111Small cell lung cancer_Homo sapiens_hsa052220.21044203
112Steroid biosynthesis_Homo sapiens_hsa001000.11801940
113FoxO signaling pathway_Homo sapiens_hsa040680.11238047
114Adherens junction_Homo sapiens_hsa045200.09745369
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.09401046
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.07926343
117Ether lipid metabolism_Homo sapiens_hsa005650.07375237
118Renin-angiotensin system_Homo sapiens_hsa046140.06561585
119Bladder cancer_Homo sapiens_hsa052190.05853606
120Pathways in cancer_Homo sapiens_hsa052000.04571426
121Wnt signaling pathway_Homo sapiens_hsa043100.04433882
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.02808652
123Galactose metabolism_Homo sapiens_hsa000520.02203768
124Mineral absorption_Homo sapiens_hsa049780.02068868
125HIF-1 signaling pathway_Homo sapiens_hsa040660.01473875
126Apoptosis_Homo sapiens_hsa042100.01421403
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.01289693
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.00816849
129Circadian rhythm_Homo sapiens_hsa04710-0.0412431
130beta-Alanine metabolism_Homo sapiens_hsa00410-0.0364987
131Prostate cancer_Homo sapiens_hsa05215-0.0342717
132Sphingolipid metabolism_Homo sapiens_hsa00600-0.0243270
133Colorectal cancer_Homo sapiens_hsa05210-0.0168057
134Alcoholism_Homo sapiens_hsa05034-0.0131671
135Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524-0.0129278
136Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0121969
137Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0101065
138Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0022481

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