ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	7.62762496
2	ribosomal small subunit assembly (GO:0000028)	7.27822233
3	negative regulation of telomere maintenance (GO:0032205)	7.12685309
4	ATP synthesis coupled proton transport (GO:0015986)	6.87565895
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.87565895
6	protein-cofactor linkage (GO:0018065)	6.66593624
7	regulation of cellular respiration (GO:0043457)	6.48169629
8	respiratory electron transport chain (GO:0022904)	6.31152672
9	electron transport chain (GO:0022900)	6.20126527
10	synaptic vesicle endocytosis (GO:0048488)	5.79911828
11	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.71195810
12	regulation of double-strand break repair via homologous recombination (GO:0010569)	5.61334935
13	retinal cone cell development (GO:0046549)	5.42560389
14	positive regulation of guanylate cyclase activity (GO:0031284)	5.13376961
15	protein neddylation (GO:0045116)	5.08441750
16	negative regulation of DNA recombination (GO:0045910)	5.07231155
17	monoubiquitinated protein deubiquitination (GO:0035520)	4.75729588
18	telomere maintenance via telomerase (GO:0007004)	4.74749887
19	regulation of guanylate cyclase activity (GO:0031282)	4.65275562
20	negative regulation of heart rate (GO:0010459)	4.64203210
21	positive regulation of fibroblast migration (GO:0010763)	4.52073727
22	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	4.45331812
23	detection of light stimulus involved in sensory perception (GO:0050962)	4.41893102
24	detection of light stimulus involved in visual perception (GO:0050908)	4.41893102
25	receptor guanylyl cyclase signaling pathway (GO:0007168)	4.23401052
26	regulation of telomere maintenance (GO:0032204)	3.99807832
27	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.94616931
28	NADH dehydrogenase complex assembly (GO:0010257)	3.94616931
29	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.94616931
30	ribosomal large subunit biogenesis (GO:0042273)	3.88492316
31	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.85857558
32	hydrogen ion transmembrane transport (GO:1902600)	3.78126004
33	L-methionine salvage (GO:0071267)	3.65689108
34	L-methionine biosynthetic process (GO:0071265)	3.65689108
35	amino acid salvage (GO:0043102)	3.65689108
36	ATP biosynthetic process (GO:0006754)	3.64035822
37	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	3.63323995
38	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)	3.61680842
39	mitochondrial calcium ion homeostasis (GO:0051560)	3.60940606
40	organelle disassembly (GO:1903008)	3.58573339
41	protein complex biogenesis (GO:0070271)	3.57102490
42	neuronal action potential (GO:0019228)	3.44087784
43	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.43438967
44	cotranslational protein targeting to membrane (GO:0006613)	3.40151496
45	protein targeting to ER (GO:0045047)	3.39932013
46	RNA-dependent DNA replication (GO:0006278)	3.39053062
47	ribonucleoprotein complex disassembly (GO:0032988)	3.36040721
48	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.35473072
49	translational termination (GO:0006415)	3.33868269
50	viral transcription (GO:0019083)	3.33438505
51	phosphorelay signal transduction system (GO:0000160)	3.31459736
52	proton transport (GO:0015992)	3.27362168
53	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.23056513
54	water-soluble vitamin biosynthetic process (GO:0042364)	3.21681754
55	protein localization to endoplasmic reticulum (GO:0070972)	3.20856469
56	poly(A)+ mRNA export from nucleus (GO:0016973)	3.17787112
57	hydrogen transport (GO:0006818)	3.17132846
58	regulation of mitochondrial translation (GO:0070129)	3.16391645
59	one-carbon compound transport (GO:0019755)	3.14031914
60	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.12009787
61	positive regulation of protein homodimerization activity (GO:0090073)	3.04499937
62	positive regulation of cGMP biosynthetic process (GO:0030828)	3.01938051
63	chromatin remodeling at centromere (GO:0031055)	3.01165413
64	inner mitochondrial membrane organization (GO:0007007)	3.00903794
65	peptidyl-histidine modification (GO:0018202)	3.00836261
66	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.00667943
67	positive regulation of skeletal muscle tissue development (GO:0048643)	2.97253018
68	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.95892705
69	fatty acid homeostasis (GO:0055089)	2.95530192
70	membrane depolarization during action potential (GO:0086010)	2.94184426
71	mitochondrial respiratory chain complex assembly (GO:0033108)	2.93677114
72	peptidyl-threonine dephosphorylation (GO:0035970)	2.89409790
73	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.86918790
74	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.86390256
75	histone mRNA metabolic process (GO:0008334)	2.85525455
76	membrane tubulation (GO:0097320)	2.84074520
77	maturation of 5.8S rRNA (GO:0000460)	2.83443355
78	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.83014612
79	regulation of cGMP biosynthetic process (GO:0030826)	2.82686584
80	centriole replication (GO:0007099)	2.79527927
81	glycerophospholipid catabolic process (GO:0046475)	2.77878223
82	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.77378922
83	regulation of protein heterodimerization activity (GO:0043497)	2.76537241
84	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.75163605
85	positive regulation of heart rate (GO:0010460)	2.73672944
86	regulation of glomerular filtration (GO:0003093)	2.72604836
87	CENP-A containing nucleosome assembly (GO:0034080)	2.71990196
88	DNA strand renaturation (GO:0000733)	2.71710316
89	protein localization to synapse (GO:0035418)	2.69939619
90	respiratory chain complex IV assembly (GO:0008535)	2.69056071
91	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.66193858
92	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.66107808
93	positive regulation of RNA splicing (GO:0033120)	2.65830596
94	positive regulation of cGMP metabolic process (GO:0030825)	2.64436342
95	artery smooth muscle contraction (GO:0014824)	2.60408492
96	kinetochore assembly (GO:0051382)	2.59726042
97	regulation of energy homeostasis (GO:2000505)	2.57501625
98	platelet dense granule organization (GO:0060155)	2.57325365
99	histone exchange (GO:0043486)	2.55969436
100	GPI anchor biosynthetic process (GO:0006506)	2.52807761

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.45058392
2	FLI1_27457419_Chip-Seq_LIVER_Mouse	3.26377525
3	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.24450823
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.24255796
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.24007701
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.09268259
7	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	3.04759185
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.03181410
9	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.82389225
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.71637861
11	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.70913455
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.35807863
13	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.28986826
14	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.28654937
15	PCGF2_27294783_Chip-Seq_NPCs_Mouse	2.25200786
16	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.21142233
17	EWS_26573619_Chip-Seq_HEK293_Human	2.18975736
18	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.14811919
19	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.09496530
20	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.03089593
21	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.95114535
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.91549393
23	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.91265134
24	FUS_26573619_Chip-Seq_HEK293_Human	1.90808444
25	TP53_22573176_ChIP-Seq_HFKS_Human	1.85324479
26	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.81954003
27	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.80776542
28	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.72565845
29	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.72555620
30	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.67487706
31	P300_19829295_ChIP-Seq_ESCs_Human	1.66011856
32	BCAT_22108803_ChIP-Seq_LS180_Human	1.57525421
33	ER_23166858_ChIP-Seq_MCF-7_Human	1.53135139
34	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.50729027
35	ELK1_19687146_ChIP-ChIP_HELA_Human	1.49462089
36	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.48217532
37	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.47921838
38	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.42711955
39	VDR_23849224_ChIP-Seq_CD4+_Human	1.42529367
40	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.42297242
41	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.40299587
42	FOXP3_21729870_ChIP-Seq_TREG_Human	1.37301943
43	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.35673971
44	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.33894017
45	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.33855898
46	TCF4_22108803_ChIP-Seq_LS180_Human	1.32859179
47	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.32552394
48	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.28636893
49	IGF1R_20145208_ChIP-Seq_DFB_Human	1.27141467
50	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.27078177
51	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.26634844
52	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.26615881
53	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.26219116
54	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.25790649
55	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.24954835
56	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.23465140
57	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.23388520
58	MYC_18940864_ChIP-ChIP_HL60_Human	1.23319537
59	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.23319322
60	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.23024964
61	JUN_21703547_ChIP-Seq_K562_Human	1.21566086
62	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.21416018
63	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.21353538
64	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.19608611
65	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.17305450
66	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17275420
67	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.16885348
68	P53_22387025_ChIP-Seq_ESCs_Mouse	1.14937356
69	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.13725674
70	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.11082949
71	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.09252110
72	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.08184731
73	REST_19997604_ChIP-ChIP_NEURONS_Mouse	1.06065082
74	REST_21632747_ChIP-Seq_MESCs_Mouse	1.04526492
75	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.03336428
76	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.02559049
77	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.01285486
78	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.00726503
79	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.00333748
80	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.99876162
81	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.98429539
82	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.97686485
83	TTF2_22483619_ChIP-Seq_HELA_Human	0.97352751
84	EGR1_19032775_ChIP-ChIP_M12_Human	0.97343565
85	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.96983336
86	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.96914065
87	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.96556196
88	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.96342798
89	AR_20517297_ChIP-Seq_VCAP_Human	0.96158379
90	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.95484631
91	RUNX2_22187159_ChIP-Seq_PCA_Human	0.95448650
92	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.95263667
93	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.94849475
94	CBP_20019798_ChIP-Seq_JUKART_Human	0.94800936
95	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.94800936
96	AR_25329375_ChIP-Seq_VCAP_Human	0.94745928
97	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.94325812
98	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.93938126
99	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.93864356
100	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.93704261

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001188_hyperpigmentation	4.35736844
2	MP0000516_abnormal_urinary_system	3.79536602
3	MP0005367_renal/urinary_system_phenotyp	3.79536602
4	MP0001486_abnormal_startle_reflex	3.43274966
5	MP0001485_abnormal_pinna_reflex	3.31967734
6	MP0009046_muscle_twitch	3.09985453
7	MP0002653_abnormal_ependyma_morphology	3.09540854
8	MP0003122_maternal_imprinting	3.06449701
9	MP0000751_myopathy	3.05226235
10	MP0008877_abnormal_DNA_methylation	2.96149826
11	MP0005551_abnormal_eye_electrophysiolog	2.61485689
12	MP0003646_muscle_fatigue	2.52361913
13	MP0003121_genomic_imprinting	2.42444081
14	MP0003787_abnormal_imprinting	2.40539541
15	MP0003693_abnormal_embryo_hatching	2.37877165
16	MP0003718_maternal_effect	2.27547889
17	MP0004142_abnormal_muscle_tone	2.15877209
18	MP0000749_muscle_degeneration	2.12168172
19	MP0003315_abnormal_perineum_morphology	2.08722397
20	MP0008007_abnormal_cellular_replicative	2.06411878
21	MP0009745_abnormal_behavioral_response	1.93458261
22	MP0004233_abnormal_muscle_weight	1.92805534
23	MP0002090_abnormal_vision	1.84662114
24	MP0002751_abnormal_autonomic_nervous	1.73853503
25	MP0006036_abnormal_mitochondrial_physio	1.68753966
26	MP0001501_abnormal_sleep_pattern	1.67590563
27	MP0002064_seizures	1.66223977
28	MP0002272_abnormal_nervous_system	1.61286725
29	MP0002572_abnormal_emotion/affect_behav	1.58964613
30	MP0008789_abnormal_olfactory_epithelium	1.58776353
31	MP0002102_abnormal_ear_morphology	1.53476415
32	MP0005394_taste/olfaction_phenotype	1.38822218
33	MP0005499_abnormal_olfactory_system	1.38822218
34	MP0006292_abnormal_olfactory_placode	1.38607479
35	MP0002735_abnormal_chemical_nociception	1.36793298
36	MP0006072_abnormal_retinal_apoptosis	1.36301230
37	MP0004270_analgesia	1.35703679
38	MP0000747_muscle_weakness	1.33646335
39	MP0010386_abnormal_urinary_bladder	1.33138764
40	MP0002733_abnormal_thermal_nociception	1.29298849
41	MP0005408_hypopigmentation	1.29044880
42	MP0001970_abnormal_pain_threshold	1.26705333
43	MP0010094_abnormal_chromosome_stability	1.24645936
44	MP0001529_abnormal_vocalization	1.22732773
45	MP0002184_abnormal_innervation	1.22646114
46	MP0003786_premature_aging	1.20049754
47	MP0006276_abnormal_autonomic_nervous	1.18892792
48	MP0003123_paternal_imprinting	1.18671847
49	MP0008058_abnormal_DNA_repair	1.15187843
50	MP0005386_behavior/neurological_phenoty	1.13199005
51	MP0004924_abnormal_behavior	1.13199005
52	MP0003195_calcinosis	1.13152541
53	MP0002557_abnormal_social/conspecific_i	1.10503145
54	MP0003635_abnormal_synaptic_transmissio	1.10079716
55	MP0002063_abnormal_learning/memory/cond	1.09517164
56	MP0001440_abnormal_grooming_behavior	1.09259232
57	MP0001919_abnormal_reproductive_system	1.08243394
58	MP0005253_abnormal_eye_physiology	1.07773986
59	MP0005646_abnormal_pituitary_gland	1.05155548
60	MP0002877_abnormal_melanocyte_morpholog	1.01923224
61	MP0002734_abnormal_mechanical_nocicepti	1.00356711
62	MP0005395_other_phenotype	0.95023385
63	MP0004742_abnormal_vestibular_system	0.94503898
64	MP0005195_abnormal_posterior_eye	0.93351595
65	MP0005266_abnormal_metabolism	0.93324633
66	MP0005448_abnormal_energy_balance	0.90492873
67	MP0003959_abnormal_lean_body	0.90030544
68	MP0001324_abnormal_eye_pigmentation	0.89684105
69	MP0001929_abnormal_gametogenesis	0.89344016
70	MP0002277_abnormal_respiratory_mucosa	0.87595268
71	MP0000537_abnormal_urethra_morphology	0.84158161
72	MP0003880_abnormal_central_pattern	0.82213688
73	MP0005389_reproductive_system_phenotype	0.81848852
74	MP0005197_abnormal_uvea_morphology	0.81137240
75	MP0002837_dystrophic_cardiac_calcinosis	0.80851767
76	MP0009764_decreased_sensitivity_to	0.80181891
77	MP0004147_increased_porphyrin_level	0.79292173
78	MP0004145_abnormal_muscle_electrophysio	0.79104857
79	MP0004043_abnormal_pH_regulation	0.79081561
80	MP0002876_abnormal_thyroid_physiology	0.78941021
81	MP0003950_abnormal_plasma_membrane	0.77617616
82	MP0004019_abnormal_vitamin_homeostasis	0.77025008
83	MP0000538_abnormal_urinary_bladder	0.76955543
84	MP0002752_abnormal_somatic_nervous	0.76087176
85	MP0001984_abnormal_olfaction	0.74104885
86	MP0002938_white_spotting	0.71942227
87	MP0005084_abnormal_gallbladder_morpholo	0.71867789
88	MP0001764_abnormal_homeostasis	0.71253377
89	MP0004215_abnormal_myocardial_fiber	0.70944730
90	MP0003011_delayed_dark_adaptation	0.70940192
91	MP0001293_anophthalmia	0.69623929
92	MP0002229_neurodegeneration	0.68614972
93	MP0002282_abnormal_trachea_morphology	0.65869461
94	MP0006035_abnormal_mitochondrial_morpho	0.65345308
95	MP0003119_abnormal_digestive_system	0.65309062
96	MP0001905_abnormal_dopamine_level	0.64136671
97	MP0002160_abnormal_reproductive_system	0.62876094
98	MP0002882_abnormal_neuron_morphology	0.62037928
99	MP0000955_abnormal_spinal_cord	0.61975087
100	MP0002736_abnormal_nociception_after	0.61666368

Predicted human phenotypes

Rank	Gene Set	Z-score
1	3-Methylglutaconic aciduria (HP:0003535)	5.78640945
2	Acute necrotizing encephalopathy (HP:0006965)	5.25149093
3	Hyperalaninemia (HP:0003348)	4.53670113
4	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	4.53670113
5	Abnormality of alanine metabolism (HP:0010916)	4.53670113
6	Abnormal mitochondria in muscle tissue (HP:0008316)	4.46898954
7	Amblyopia (HP:0000646)	4.32737940
8	Progressive macrocephaly (HP:0004481)	4.32320170
9	Supernumerary spleens (HP:0009799)	4.16193162
10	Congenital, generalized hypertrichosis (HP:0004540)	4.14296395
11	Abnormality of the labia minora (HP:0012880)	4.05479792
12	Acute encephalopathy (HP:0006846)	4.05029619
13	Gaze-evoked nystagmus (HP:0000640)	3.83288198
14	Mitochondrial inheritance (HP:0001427)	3.74222178
15	Hydroureter (HP:0000072)	3.71224062
16	Epileptic encephalopathy (HP:0200134)	3.55023540
17	Leukodystrophy (HP:0002415)	3.53139000
18	Increased CSF lactate (HP:0002490)	3.49583873
19	Hepatic necrosis (HP:0002605)	3.43241954
20	Hepatocellular necrosis (HP:0001404)	3.35043292
21	Ulnar claw (HP:0001178)	3.29269125
22	Abnormality of the proximal phalanges of the hand (HP:0009834)	3.21134460
23	Methylmalonic acidemia (HP:0002912)	3.15207952
24	Progressive inability to walk (HP:0002505)	3.09013199
25	Optic nerve hypoplasia (HP:0000609)	3.09006986
26	Cerebral edema (HP:0002181)	3.03621839
27	Focal motor seizures (HP:0011153)	3.03618318
28	Abnormality of cells of the erythroid lineage (HP:0012130)	2.93325186
29	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.88955651
30	Colon cancer (HP:0003003)	2.88860688
31	Abnormal number of erythroid precursors (HP:0012131)	2.79494367
32	Hyperglycinemia (HP:0002154)	2.72410394
33	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.67431223
34	Medial flaring of the eyebrow (HP:0010747)	2.62812311
35	Methylmalonic aciduria (HP:0012120)	2.59527744
36	Peripheral hypomyelination (HP:0007182)	2.59326797
37	Type II lissencephaly (HP:0007260)	2.58875828
38	Oral leukoplakia (HP:0002745)	2.58469129
39	Pancreatic cysts (HP:0001737)	2.53952875
40	Flared iliac wings (HP:0002869)	2.53391339
41	Optic disc pallor (HP:0000543)	2.51779773
42	Reticulocytopenia (HP:0001896)	2.50583005
43	Gait imbalance (HP:0002141)	2.47350527
44	Febrile seizures (HP:0002373)	2.39400954
45	Birth length less than 3rd percentile (HP:0003561)	2.37843064
46	Duplication of thumb phalanx (HP:0009942)	2.37725741
47	Abnormality of the middle phalanges of the toes (HP:0010183)	2.37190641
48	Increased serum lactate (HP:0002151)	2.35887516
49	Hypoplasia of the fovea (HP:0007750)	2.33032425
50	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.33032425
51	Myokymia (HP:0002411)	2.32794185
52	Congenital primary aphakia (HP:0007707)	2.32446825
53	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.31766183
54	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.29421548
55	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.29421548
56	Inability to walk (HP:0002540)	2.24789396
57	Coronal craniosynostosis (HP:0004440)	2.24789242
58	Pancreatic fibrosis (HP:0100732)	2.24485406
59	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.24100029
60	Short 1st metacarpal (HP:0010034)	2.24100029
61	Focal seizures (HP:0007359)	2.20188413
62	Lactic acidosis (HP:0003128)	2.18079466
63	Abnormality of macular pigmentation (HP:0008002)	2.16813035
64	Abnormality of serum amino acid levels (HP:0003112)	2.15864594
65	Absent thumb (HP:0009777)	2.14704404
66	Nephronophthisis (HP:0000090)	2.13612594
67	Retinal dysplasia (HP:0007973)	2.13120900
68	Emotional lability (HP:0000712)	2.12891189
69	True hermaphroditism (HP:0010459)	2.09213890
70	Chromsome breakage (HP:0040012)	2.07777545
71	Failure to thrive in infancy (HP:0001531)	2.05044504
72	Aplastic anemia (HP:0001915)	2.03023527
73	Prostate neoplasm (HP:0100787)	2.02524860
74	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.02409896
75	Abnormality of the 1st metacarpal (HP:0010009)	1.99937416
76	Respiratory failure (HP:0002878)	1.99810228
77	Stenosis of the external auditory canal (HP:0000402)	1.99424984
78	Oligomenorrhea (HP:0000876)	1.97996699
79	Abnormal auditory evoked potentials (HP:0006958)	1.97568751
80	Abnormal hair whorl (HP:0010721)	1.96817836
81	Abnormality of the fovea (HP:0000493)	1.94641480
82	Sensory axonal neuropathy (HP:0003390)	1.92300963
83	Nephrogenic diabetes insipidus (HP:0009806)	1.91587529
84	Abnormality of the vocal cords (HP:0008777)	1.91485441
85	Hyperventilation (HP:0002883)	1.86733862
86	Impulsivity (HP:0100710)	1.85441052
87	Lethargy (HP:0001254)	1.85253440
88	Sacral dimple (HP:0000960)	1.81007342
89	Preaxial foot polydactyly (HP:0001841)	1.78818505
90	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	1.76223925
91	Sleep apnea (HP:0010535)	1.75502079
92	Congenital stationary night blindness (HP:0007642)	1.74785792
93	Hyperphosphatemia (HP:0002905)	1.73402102
94	Genital tract atresia (HP:0001827)	1.73170839
95	Increased serum pyruvate (HP:0003542)	1.72373162
96	Abnormality of the renal medulla (HP:0100957)	1.70771925
97	X-linked dominant inheritance (HP:0001423)	1.70200911
98	CNS demyelination (HP:0007305)	1.69057748
99	Abnormality of the ileum (HP:0001549)	1.68588582
100	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.68114581

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK19	5.61598523
2	CDC7	4.49922947
3	OXSR1	3.35967330
4	MAP3K12	3.29901124
5	PNCK	2.75478257
6	VRK2	2.70842551
7	DYRK1A	2.49515075
8	MAPKAPK5	2.40725155
9	MKNK1	2.34337993
10	TRIM28	2.20849272
11	PLK4	2.00045219
12	NUAK1	1.99738865
13	PDK2	1.93774131
14	CAMKK2	1.81081566
15	BRSK2	1.71261354
16	MAP3K11	1.64221338
17	TLK1	1.63978064
18	TAF1	1.58614757
19	WNK3	1.48675516
20	ZAK	1.46658992
21	BRSK1	1.37128302
22	ADRBK2	1.33954190
23	FLT3	1.32244900
24	CDK18	1.31256533
25	BUB1	1.26327200
26	SIK2	1.23144531
27	CDK15	1.21346247
28	ERN1	1.15968298
29	CDK11A	1.15822166
30	GRK1	1.12991054
31	PLK2	1.12439006
32	CDK14	1.05856072
33	CAMK1G	1.04673485
34	CSNK1G3	1.03594374
35	DYRK2	1.01617432
36	CHEK2	1.01131948
37	CSNK1G1	0.99631719
38	ATR	0.99609192
39	SIK3	0.98368365
40	VRK1	0.95752150
41	WNK4	0.94010358
42	FRK	0.92247597
43	CSNK1G2	0.90220283
44	CDK9	0.88416900
45	FER	0.87362288
46	STK11	0.86026694
47	STK39	0.85762736
48	PINK1	0.85012044
49	BCKDK	0.85010401
50	TIE1	0.84027309
51	CAMK1	0.83761367
52	PKN2	0.80691232
53	MINK1	0.78761877
54	MARK1	0.77701988
55	CSNK1A1L	0.75460792
56	INSRR	0.74114018
57	CAMK2A	0.70154213
58	ALK	0.67706260
59	SMG1	0.67534019
60	PLK3	0.66397671
61	NEK1	0.66064654
62	PRKCG	0.65052240
63	EGFR	0.63029895
64	BMPR1B	0.60893488
65	MKNK2	0.60791652
66	PRKAA2	0.60497723
67	AURKB	0.59913554
68	MAP4K2	0.59436793
69	LYN	0.59227642
70	TXK	0.58363394
71	PRKAA1	0.58252734
72	ABL2	0.57503531
73	GRK5	0.56891726
74	MELK	0.56388077
75	PIK3CA	0.56002294
76	MAPK13	0.54289750
77	RPS6KA5	0.52959339
78	PRKCE	0.52914969
79	PRKCZ	0.51367487
80	CSNK1A1	0.51103546
81	PRKACB	0.50801963
82	DAPK3	0.50496783
83	FES	0.49870949
84	CDK3	0.47666820
85	MAP2K4	0.45180295
86	STK4	0.43702557
87	BCR	0.43634430
88	PAK3	0.41920011
89	CDK5	0.41667065
90	ADRBK1	0.41259558
91	GSK3A	0.40578060
92	SGK1	0.39348497
93	MAP3K5	0.37102346
94	CSNK1E	0.36845614
95	WEE1	0.35861493
96	CSNK2A2	0.35656254
97	TSSK6	0.35001374
98	OBSCN	0.34901647
99	ACVR1B	0.33883639
100	TNIK	0.33152419

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	5.15308878
2	Phototransduction_Homo sapiens_hsa04744	4.53301226
3	Parkinsons disease_Homo sapiens_hsa05012	4.50805975
4	Cardiac muscle contraction_Homo sapiens_hsa04260	3.95076930
5	Protein export_Homo sapiens_hsa03060	3.59646103
6	Alzheimers disease_Homo sapiens_hsa05010	3.55875110
7	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.33193544
8	Huntingtons disease_Homo sapiens_hsa05016	3.17314469
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	3.11230248
10	Ribosome_Homo sapiens_hsa03010	2.87329888
11	Nicotine addiction_Homo sapiens_hsa05033	2.35993503
12	Homologous recombination_Homo sapiens_hsa03440	2.08205076
13	Proteasome_Homo sapiens_hsa03050	1.85106268
14	Fanconi anemia pathway_Homo sapiens_hsa03460	1.83561526
15	Non-homologous end-joining_Homo sapiens_hsa03450	1.57508712
16	One carbon pool by folate_Homo sapiens_hsa00670	1.54867156
17	Circadian rhythm_Homo sapiens_hsa04710	1.43012295
18	GABAergic synapse_Homo sapiens_hsa04727	1.41618235
19	RNA degradation_Homo sapiens_hsa03018	1.41489988
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.29350667
21	Nitrogen metabolism_Homo sapiens_hsa00910	1.23463201
22	Spliceosome_Homo sapiens_hsa03040	1.21701902
23	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.16887563
24	Morphine addiction_Homo sapiens_hsa05032	1.15047778
25	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.14800045
26	Sulfur metabolism_Homo sapiens_hsa00920	1.10224606
27	RNA polymerase_Homo sapiens_hsa03020	1.07927905
28	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.03713331
29	Pyrimidine metabolism_Homo sapiens_hsa00240	1.02497022
30	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.01239292
31	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.01139745
32	Mismatch repair_Homo sapiens_hsa03430	0.99492342
33	DNA replication_Homo sapiens_hsa03030	0.98067349
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.93977151
35	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.92591104
36	Propanoate metabolism_Homo sapiens_hsa00640	0.92341099
37	Linoleic acid metabolism_Homo sapiens_hsa00591	0.87297982
38	Arginine and proline metabolism_Homo sapiens_hsa00330	0.85674733
39	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.84339883
40	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.83180714
41	Purine metabolism_Homo sapiens_hsa00230	0.82766400
42	Olfactory transduction_Homo sapiens_hsa04740	0.81362704
43	Asthma_Homo sapiens_hsa05310	0.77817800
44	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.73876290
45	Phenylalanine metabolism_Homo sapiens_hsa00360	0.73690695
46	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.71732235
47	Nucleotide excision repair_Homo sapiens_hsa03420	0.70538848
48	Folate biosynthesis_Homo sapiens_hsa00790	0.68723260
49	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.68524017
50	Taste transduction_Homo sapiens_hsa04742	0.67843363
51	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.64219906
52	Tyrosine metabolism_Homo sapiens_hsa00350	0.61811600
53	Pyruvate metabolism_Homo sapiens_hsa00620	0.60907128
54	Basal transcription factors_Homo sapiens_hsa03022	0.59908606
55	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.59286349
56	Fatty acid elongation_Homo sapiens_hsa00062	0.59195804
57	Metabolic pathways_Homo sapiens_hsa01100	0.58203027
58	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.57376336
59	Retinol metabolism_Homo sapiens_hsa00830	0.57370525
60	Caffeine metabolism_Homo sapiens_hsa00232	0.56200008
61	Arginine biosynthesis_Homo sapiens_hsa00220	0.55491667
62	Peroxisome_Homo sapiens_hsa04146	0.54908878
63	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.54267521
64	Glutamatergic synapse_Homo sapiens_hsa04724	0.52504305
65	beta-Alanine metabolism_Homo sapiens_hsa00410	0.50225739
66	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.49889725
67	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.47509113
68	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.46916699
69	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.46835313
70	Circadian entrainment_Homo sapiens_hsa04713	0.46310265
71	Ether lipid metabolism_Homo sapiens_hsa00565	0.44014457
72	Cell cycle_Homo sapiens_hsa04110	0.40336843
73	Serotonergic synapse_Homo sapiens_hsa04726	0.39459895
74	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.39206968
75	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.36699579
76	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.36557309
77	RNA transport_Homo sapiens_hsa03013	0.35584633
78	Butanoate metabolism_Homo sapiens_hsa00650	0.35420349
79	Tryptophan metabolism_Homo sapiens_hsa00380	0.33762795
80	p53 signaling pathway_Homo sapiens_hsa04115	0.32273830
81	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.30795328
82	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.28578900
83	Steroid biosynthesis_Homo sapiens_hsa00100	0.25850921
84	Insulin secretion_Homo sapiens_hsa04911	0.25201861
85	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.25056235
86	Regulation of autophagy_Homo sapiens_hsa04140	0.24375460
87	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.23439872
88	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.23212069
89	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.22532814
90	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.20996158
91	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.19723312
92	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.18178522
93	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.17948625
94	Wnt signaling pathway_Homo sapiens_hsa04310	0.17725892
95	Fatty acid degradation_Homo sapiens_hsa00071	0.17526644
96	Chemical carcinogenesis_Homo sapiens_hsa05204	0.15620460
97	Salivary secretion_Homo sapiens_hsa04970	0.15337969
98	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.15164961
99	Histidine metabolism_Homo sapiens_hsa00340	0.12909727
100	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.12399067

CCNB1IP1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »