

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | protein localization to kinetochore (GO:0034501) | 5.42188940 |
| 2 | mitotic metaphase plate congression (GO:0007080) | 5.22064057 |
| 3 | kinetochore organization (GO:0051383) | 5.19194972 |
| 4 | protein localization to chromosome, centromeric region (GO:0071459) | 5.14642357 |
| 5 | mitotic sister chromatid segregation (GO:0000070) | 4.90949871 |
| 6 | CENP-A containing nucleosome assembly (GO:0034080) | 4.81269704 |
| 7 | chromatin remodeling at centromere (GO:0031055) | 4.73924629 |
| 8 | kinetochore assembly (GO:0051382) | 4.73607493 |
| 9 | metaphase plate congression (GO:0051310) | 4.65045910 |
| 10 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.63630719 |
| 11 | sister chromatid segregation (GO:0000819) | 4.49903539 |
| 12 | attachment of spindle microtubules to kinetochore (GO:0008608) | 4.49527573 |
| 13 | establishment of chromosome localization (GO:0051303) | 4.49180845 |
| 14 | DNA unwinding involved in DNA replication (GO:0006268) | 4.42740511 |
| 15 | mitotic chromosome condensation (GO:0007076) | 4.42173744 |
| 16 | DNA strand elongation (GO:0022616) | 4.40017987 |
| 17 | regulation of spindle organization (GO:0090224) | 4.37764108 |
| 18 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.36639638 |
| 19 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 4.32225559 |
| 20 | DNA replication initiation (GO:0006270) | 4.31325735 |
| 21 | DNA replication-independent nucleosome organization (GO:0034724) | 4.28203501 |
| 22 | DNA replication-independent nucleosome assembly (GO:0006336) | 4.28203501 |
| 23 | ribosomal small subunit assembly (GO:0000028) | 4.13111539 |
| 24 | DNA replication checkpoint (GO:0000076) | 4.02309775 |
| 25 | histone exchange (GO:0043486) | 4.01402215 |
| 26 | * mitotic nuclear envelope disassembly (GO:0007077) | 3.99502257 |
| 27 | telomere maintenance via recombination (GO:0000722) | 3.97354986 |
| 28 | mitotic recombination (GO:0006312) | 3.92679886 |
| 29 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.83362646 |
| 30 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.83362646 |
| 31 | meiotic chromosome segregation (GO:0045132) | 3.81325360 |
| 32 | spindle checkpoint (GO:0031577) | 3.78931679 |
| 33 | regulation of mitotic spindle organization (GO:0060236) | 3.78743585 |
| 34 | negative regulation of mitosis (GO:0045839) | 3.76404449 |
| 35 | maturation of SSU-rRNA (GO:0030490) | 3.71692212 |
| 36 | formation of translation preinitiation complex (GO:0001731) | 3.70619461 |
| 37 | * nuclear envelope disassembly (GO:0051081) | 3.67801465 |
| 38 | * membrane disassembly (GO:0030397) | 3.67801465 |
| 39 | regulation of chromosome segregation (GO:0051983) | 3.66392564 |
| 40 | positive regulation of chromosome segregation (GO:0051984) | 3.63510594 |
| 41 | spindle assembly checkpoint (GO:0071173) | 3.63123021 |
| 42 | negative regulation of chromosome segregation (GO:0051985) | 3.61426979 |
| 43 | protein localization to chromosome (GO:0034502) | 3.61407290 |
| 44 | telomere maintenance via telomere lengthening (GO:0010833) | 3.59596352 |
| 45 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.59354308 |
| 46 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.59354308 |
| 47 | negative regulation of sister chromatid segregation (GO:0033046) | 3.59354308 |
| 48 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.59354308 |
| 49 | DNA deamination (GO:0045006) | 3.54201347 |
| 50 | mitotic spindle assembly checkpoint (GO:0007094) | 3.53151400 |
| 51 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.51441750 |
| 52 | ventricular cardiac muscle cell development (GO:0055015) | 3.50504558 |
| 53 | viral transcription (GO:0019083) | 3.48888709 |
| 54 | chromosome segregation (GO:0007059) | 3.48540607 |
| 55 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 3.48443972 |
| 56 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.47530386 |
| 57 | nuclear pore organization (GO:0006999) | 3.47504914 |
| 58 | proteasome assembly (GO:0043248) | 3.47141952 |
| 59 | translational termination (GO:0006415) | 3.45550690 |
| 60 | mitotic spindle checkpoint (GO:0071174) | 3.45255523 |
| 61 | DNA packaging (GO:0006323) | 3.44093870 |
| 62 | mitotic sister chromatid cohesion (GO:0007064) | 3.43194005 |
| 63 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 3.42577685 |
| 64 | DNA topological change (GO:0006265) | 3.39112748 |
| 65 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.35059067 |
| 66 | chromatin assembly or disassembly (GO:0006333) | 3.34205665 |
| 67 | regulation of mitotic sister chromatid separation (GO:0010965) | 3.32867658 |
| 68 | regulation of mitotic sister chromatid segregation (GO:0033047) | 3.32867658 |
| 69 | regulation of sister chromatid segregation (GO:0033045) | 3.32867658 |
| 70 | establishment of viral latency (GO:0019043) | 3.32665313 |
| 71 | nuclear pore complex assembly (GO:0051292) | 3.31800672 |
| 72 | negative regulation of nuclear division (GO:0051784) | 3.31374296 |
| 73 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.30591329 |
| 74 | regulation of centriole replication (GO:0046599) | 3.29822599 |
| 75 | regulation of sister chromatid cohesion (GO:0007063) | 3.29778231 |
| 76 | nucleobase biosynthetic process (GO:0046112) | 3.29543723 |
| 77 | mitotic G2/M transition checkpoint (GO:0044818) | 3.29175368 |
| 78 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435) | 3.27077806 |
| 79 | negative regulation of cell division (GO:0051782) | 3.26953293 |
| 80 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 3.26915727 |
| 81 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 3.26915727 |
| 82 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 3.26915727 |
| 83 | protein K6-linked ubiquitination (GO:0085020) | 3.25433099 |
| 84 | ribosomal large subunit biogenesis (GO:0042273) | 3.24918410 |
| 85 | translational elongation (GO:0006414) | 3.21570476 |
| 86 | ATP-dependent chromatin remodeling (GO:0043044) | 3.21444867 |
| 87 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.18523492 |
| 88 | negative regulation of ligase activity (GO:0051352) | 3.18523492 |
| 89 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.17973481 |
| 90 | ribosomal small subunit biogenesis (GO:0042274) | 3.16530503 |
| 91 | regulation of centrosome cycle (GO:0046605) | 3.15880970 |
| 92 | synapsis (GO:0007129) | 3.15835313 |
| 93 | translational initiation (GO:0006413) | 3.14261599 |
| 94 | chromosome condensation (GO:0030261) | 3.14152522 |
| 95 | resolution of meiotic recombination intermediates (GO:0000712) | 3.13497809 |
| 96 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.10234855 |
| 97 | spindle assembly involved in mitosis (GO:0090307) | 3.09912970 |
| 98 | DNA duplex unwinding (GO:0032508) | 3.08216498 |
| 99 | non-recombinational repair (GO:0000726) | 3.07787889 |
| 100 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.07787889 |
| 101 | IMP biosynthetic process (GO:0006188) | 3.07782185 |
| 102 | negative regulation of proteasomal protein catabolic process (GO:1901799) | 3.06782830 |
| 103 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.06673600 |
| 104 | DNA geometric change (GO:0032392) | 3.06584095 |
| 105 | microtubule depolymerization (GO:0007019) | 3.06165441 |
| 106 | mitotic spindle organization (GO:0007052) | 3.03517762 |
| 107 | purine nucleobase biosynthetic process (GO:0009113) | 3.02955663 |
| 108 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.02848747 |
| 109 | establishment of integrated proviral latency (GO:0075713) | 3.02841050 |
| 110 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.02528036 |
| 111 | * mitotic cell cycle (GO:0000278) | 3.02105435 |
| 112 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.01481180 |
| 113 | * mitotic nuclear division (GO:0007067) | 2.98968287 |
| 114 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.98098832 |
| 115 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.98098832 |
| 116 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.98077665 |
| 117 | replication fork processing (GO:0031297) | 2.97905562 |
| 118 | spliceosomal snRNP assembly (GO:0000387) | 2.96901036 |
| 119 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 2.96607526 |
| 120 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 2.95190750 |
| 121 | DNA conformation change (GO:0071103) | 2.94985135 |
| 122 | ribosome biogenesis (GO:0042254) | 2.94151244 |
| 123 | ribosome assembly (GO:0042255) | 2.93735488 |
| 124 | DNA ligation (GO:0006266) | 2.92020879 |
| 125 | telomere maintenance (GO:0000723) | 2.91983429 |
| 126 | telomere organization (GO:0032200) | 2.91789490 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 8.50402731 |
| 2 | * FOXM1_23109430_ChIP-Seq_U2OS_Human | 5.94040089 |
| 3 | * E2F4_17652178_ChIP-ChIP_JURKAT_Human | 4.16579895 |
| 4 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.99098656 |
| 5 | * FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.93627415 |
| 6 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.68474974 |
| 7 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.09425303 |
| 8 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.82711008 |
| 9 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.80983275 |
| 10 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.79528654 |
| 11 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.68156733 |
| 12 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.65514402 |
| 13 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.52875908 |
| 14 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.52206636 |
| 15 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.49943055 |
| 16 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.47858870 |
| 17 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.44218816 |
| 18 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.31181646 |
| 19 | * NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.29366050 |
| 20 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.28769461 |
| 21 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.19178337 |
| 22 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.11144358 |
| 23 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.09392376 |
| 24 | * MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.07285990 |
| 25 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.06073851 |
| 26 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.99316958 |
| 27 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.94467441 |
| 28 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.91676292 |
| 29 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.89732366 |
| 30 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.89453833 |
| 31 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.80933246 |
| 32 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.77849040 |
| 33 | * SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.77506985 |
| 34 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.75632775 |
| 35 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.74093290 |
| 36 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.71207628 |
| 37 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.70991963 |
| 38 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.69108159 |
| 39 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.66304929 |
| 40 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.65695660 |
| 41 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.65411734 |
| 42 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.63621919 |
| 43 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.62185635 |
| 44 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.60324108 |
| 45 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.58209998 |
| 46 | MYC_22102868_ChIP-Seq_BL_Human | 1.56072929 |
| 47 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.52172372 |
| 48 | * ELK1_19687146_ChIP-ChIP_HELA_Human | 1.49493545 |
| 49 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.47447681 |
| 50 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.47148122 |
| 51 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.44843841 |
| 52 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.43431865 |
| 53 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.39992097 |
| 54 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.36969012 |
| 55 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.33313738 |
| 56 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.31104339 |
| 57 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.25470418 |
| 58 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.24295734 |
| 59 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.23548858 |
| 60 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.22535610 |
| 61 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.22043885 |
| 62 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.21673593 |
| 63 | * SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.20601886 |
| 64 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.18100712 |
| 65 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.16582263 |
| 66 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.15736274 |
| 67 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.15307053 |
| 68 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.14426720 |
| 69 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.11921885 |
| 70 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.10978998 |
| 71 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.10663114 |
| 72 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.10572845 |
| 73 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.10043787 |
| 74 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.09448925 |
| 75 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.07201247 |
| 76 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.07188570 |
| 77 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.03469461 |
| 78 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.03410627 |
| 79 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.02685337 |
| 80 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.02170156 |
| 81 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.00012017 |
| 82 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.99159019 |
| 83 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.96762233 |
| 84 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.96389034 |
| 85 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.95680946 |
| 86 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.95099345 |
| 87 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.95000750 |
| 88 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.94512108 |
| 89 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.93904533 |
| 90 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 0.90967849 |
| 91 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.90644266 |
| 92 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.89626561 |
| 93 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.88748162 |
| 94 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.87962125 |
| 95 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.87944419 |
| 96 | EWS_26573619_Chip-Seq_HEK293_Human | 0.87620291 |
| 97 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.86212920 |
| 98 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.85991091 |
| 99 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 0.80669504 |
| 100 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.79366378 |
| 101 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.78100029 |
| 102 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 0.77828553 |
| 103 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.75177300 |
| 104 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.74034406 |
| 105 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.72569783 |
| 106 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 0.71023582 |
| 107 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 0.71023582 |
| 108 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 0.71023582 |
| 109 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.69783649 |
| 110 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.69677405 |
| 111 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.69332037 |
| 112 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.68308610 |
| 113 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.67783424 |
| 114 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 0.67668585 |
| 115 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.67423572 |
| 116 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.67099392 |
| 117 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.66866128 |
| 118 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.65999772 |
| 119 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.65230406 |
| 120 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 0.64309086 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 6.07484678 |
| 2 | MP0003111_abnormal_nucleus_morphology | 5.17575502 |
| 3 | MP0010094_abnormal_chromosome_stability | 4.97724691 |
| 4 | MP0004957_abnormal_blastocyst_morpholog | 4.67737426 |
| 5 | MP0003077_abnormal_cell_cycle | 4.38201693 |
| 6 | MP0008057_abnormal_DNA_replication | 3.96381943 |
| 7 | MP0008058_abnormal_DNA_repair | 3.17198718 |
| 8 | MP0008007_abnormal_cellular_replicative | 3.04637675 |
| 9 | MP0008932_abnormal_embryonic_tissue | 2.69901062 |
| 10 | MP0003123_paternal_imprinting | 2.37283005 |
| 11 | MP0002396_abnormal_hematopoietic_system | 2.33119883 |
| 12 | MP0001730_embryonic_growth_arrest | 2.32004351 |
| 13 | MP0000350_abnormal_cell_proliferation | 2.26159476 |
| 14 | MP0009697_abnormal_copulation | 2.03467444 |
| 15 | MP0010352_gastrointestinal_tract_polyps | 1.91812340 |
| 16 | MP0000490_abnormal_crypts_of | 1.91372454 |
| 17 | MP0010307_abnormal_tumor_latency | 1.87897698 |
| 18 | MP0008877_abnormal_DNA_methylation | 1.87837810 |
| 19 | MP0003786_premature_aging | 1.84341433 |
| 20 | MP0001697_abnormal_embryo_size | 1.74278359 |
| 21 | MP0008789_abnormal_olfactory_epithelium | 1.73012753 |
| 22 | MP0002938_white_spotting | 1.70446329 |
| 23 | MP0001672_abnormal_embryogenesis/_devel | 1.68148623 |
| 24 | MP0005380_embryogenesis_phenotype | 1.68148623 |
| 25 | MP0003718_maternal_effect | 1.63725281 |
| 26 | MP0003136_yellow_coat_color | 1.58420707 |
| 27 | * MP0002080_prenatal_lethality | 1.58093398 |
| 28 | MP0004808_abnormal_hematopoietic_stem | 1.57283436 |
| 29 | MP0002019_abnormal_tumor_incidence | 1.55801157 |
| 30 | MP0000313_abnormal_cell_death | 1.55464143 |
| 31 | MP0000566_synostosis | 1.54586813 |
| 32 | MP0003984_embryonic_growth_retardation | 1.49249691 |
| 33 | MP0005397_hematopoietic_system_phenotyp | 1.45732957 |
| 34 | MP0001545_abnormal_hematopoietic_system | 1.45732957 |
| 35 | MP0002085_abnormal_embryonic_tissue | 1.45665649 |
| 36 | MP0003937_abnormal_limbs/digits/tail_de | 1.44932745 |
| 37 | MP0002088_abnormal_embryonic_growth/wei | 1.44841235 |
| 38 | MP0002086_abnormal_extraembryonic_tissu | 1.38331875 |
| 39 | MP0003567_abnormal_fetal_cardiomyocyte | 1.37112314 |
| 40 | MP0006054_spinal_hemorrhage | 1.33483320 |
| 41 | MP0005394_taste/olfaction_phenotype | 1.31069745 |
| 42 | MP0005499_abnormal_olfactory_system | 1.31069745 |
| 43 | MP0003806_abnormal_nucleotide_metabolis | 1.29423254 |
| 44 | MP0002210_abnormal_sex_determination | 1.28617774 |
| 45 | MP0001529_abnormal_vocalization | 1.25128734 |
| 46 | MP0002084_abnormal_developmental_patter | 1.24884603 |
| 47 | MP0009333_abnormal_splenocyte_physiolog | 1.23885241 |
| 48 | MP0004197_abnormal_fetal_growth/weight/ | 1.23727893 |
| 49 | MP0000372_irregular_coat_pigmentation | 1.19678818 |
| 50 | * MP0002398_abnormal_bone_marrow | 1.18909439 |
| 51 | MP0003763_abnormal_thymus_physiology | 1.18843490 |
| 52 | MP0001929_abnormal_gametogenesis | 1.17419661 |
| 53 | * MP0000703_abnormal_thymus_morphology | 1.16181216 |
| 54 | MP0002697_abnormal_eye_size | 1.15374718 |
| 55 | MP0002233_abnormal_nose_morphology | 1.15076741 |
| 56 | MP0001145_abnormal_male_reproductive | 1.14330411 |
| 57 | MP0009379_abnormal_foot_pigmentation | 1.13995221 |
| 58 | MP0006035_abnormal_mitochondrial_morpho | 1.13041339 |
| 59 | MP0001286_abnormal_eye_development | 1.12875643 |
| 60 | MP0010030_abnormal_orbit_morphology | 1.11607191 |
| 61 | MP0003121_genomic_imprinting | 1.11588088 |
| 62 | * MP0002722_abnormal_immune_system | 1.11184735 |
| 63 | MP0005076_abnormal_cell_differentiation | 1.09610746 |
| 64 | MP0000689_abnormal_spleen_morphology | 1.06368049 |
| 65 | MP0005395_other_phenotype | 1.02016988 |
| 66 | MP0000653_abnormal_sex_gland | 0.99735896 |
| 67 | MP0003315_abnormal_perineum_morphology | 0.99011250 |
| 68 | MP0000858_altered_metastatic_potential | 0.98699950 |
| 69 | MP0003186_abnormal_redox_activity | 0.94185335 |
| 70 | MP0000049_abnormal_middle_ear | 0.92778979 |
| 71 | * MP0002429_abnormal_blood_cell | 0.92640452 |
| 72 | MP0001293_anophthalmia | 0.92573101 |
| 73 | MP0001346_abnormal_lacrimal_gland | 0.92230765 |
| 74 | MP0003656_abnormal_erythrocyte_physiolo | 0.91525080 |
| 75 | MP0002234_abnormal_pharynx_morphology | 0.89660154 |
| 76 | MP0002132_abnormal_respiratory_system | 0.86016849 |
| 77 | MP0000428_abnormal_craniofacial_morphol | 0.84986245 |
| 78 | MP0009053_abnormal_anal_canal | 0.83171644 |
| 79 | MP0001119_abnormal_female_reproductive | 0.82488727 |
| 80 | MP0003861_abnormal_nervous_system | 0.82115846 |
| 81 | MP0004147_increased_porphyrin_level | 0.82080054 |
| 82 | MP0002092_abnormal_eye_morphology | 0.82029237 |
| 83 | MP0009672_abnormal_birth_weight | 0.81408301 |
| 84 | MP0003755_abnormal_palate_morphology | 0.81093036 |
| 85 | MP0002653_abnormal_ependyma_morphology | 0.80605141 |
| 86 | MP0006072_abnormal_retinal_apoptosis | 0.79554357 |
| 87 | MP0000358_abnormal_cell_content/ | 0.78191626 |
| 88 | MP0005408_hypopigmentation | 0.78096995 |
| 89 | * MP0000716_abnormal_immune_system | 0.77473458 |
| 90 | MP0005023_abnormal_wound_healing | 0.76713648 |
| 91 | MP0009278_abnormal_bone_marrow | 0.75867031 |
| 92 | MP0005384_cellular_phenotype | 0.75826131 |
| 93 | MP0001853_heart_inflammation | 0.74790673 |
| 94 | MP0003941_abnormal_skin_development | 0.73390415 |
| 95 | MP0005621_abnormal_cell_physiology | 0.72855015 |
| 96 | MP0001915_intracranial_hemorrhage | 0.71199835 |
| 97 | MP0003890_abnormal_embryonic-extraembry | 0.70765113 |
| 98 | MP0005171_absent_coat_pigmentation | 0.69296268 |
| 99 | MP0003938_abnormal_ear_development | 0.69218672 |
| 100 | MP0000477_abnormal_intestine_morphology | 0.69183083 |
| 101 | MP0002111_abnormal_tail_morphology | 0.68954847 |
| 102 | MP0000647_abnormal_sebaceous_gland | 0.68073915 |
| 103 | MP0000537_abnormal_urethra_morphology | 0.67463541 |
| 104 | MP0005391_vision/eye_phenotype | 0.65973007 |
| 105 | MP0002160_abnormal_reproductive_system | 0.65635154 |
| 106 | MP0000579_abnormal_nail_morphology | 0.64757847 |
| 107 | MP0003935_abnormal_craniofacial_develop | 0.63510541 |
| 108 | MP0008995_early_reproductive_senescence | 0.62594086 |
| 109 | MP0003385_abnormal_body_wall | 0.62078185 |
| 110 | MP0006292_abnormal_olfactory_placode | 0.61734068 |
| 111 | MP0002095_abnormal_skin_pigmentation | 0.59771533 |
| 112 | MP0003698_abnormal_male_reproductive | 0.59649618 |
| 113 | MP0002420_abnormal_adaptive_immunity | 0.59635342 |
| 114 | MP0005389_reproductive_system_phenotype | 0.59629579 |
| 115 | MP0003566_abnormal_cell_adhesion | 0.59421989 |
| 116 | MP0001835_abnormal_antigen_presentation | 0.59187350 |
| 117 | MP0005501_abnormal_skin_physiology | 0.59059619 |
| 118 | MP0001819_abnormal_immune_cell | 0.58853580 |
| 119 | MP0001800_abnormal_humoral_immune | 0.58444807 |
| 120 | MP0003221_abnormal_cardiomyocyte_apopto | 0.58355083 |
| 121 | MP0002405_respiratory_system_inflammati | 0.58052989 |
| 122 | MP0003119_abnormal_digestive_system | 0.57943892 |
| 123 | MP0000432_abnormal_head_morphology | 0.57625800 |
| 124 | MP0001849_ear_inflammation | 0.57253705 |
| 125 | MP0006036_abnormal_mitochondrial_physio | 0.57109333 |
| 126 | MP0000465_gastrointestinal_hemorrhage | 0.56930795 |
| 127 | MP0000631_abnormal_neuroendocrine_gland | 0.56820347 |
| 128 | MP0009703_decreased_birth_body | 0.56644165 |
| 129 | MP0005075_abnormal_melanosome_morpholog | 0.56630814 |
| 130 | MP0002452_abnormal_antigen_presenting | 0.54759879 |
| 131 | MP0002102_abnormal_ear_morphology | 0.54590506 |
| 132 | * MP0002161_abnormal_fertility/fecundity | 0.54503178 |
| 133 | MP0002751_abnormal_autonomic_nervous | 0.54040586 |
| 134 | MP0000685_abnormal_immune_system | 0.53674923 |
| 135 | MP0003705_abnormal_hypodermis_morpholog | 0.53369239 |
| 136 | MP0002177_abnormal_outer_ear | 0.53236951 |
| 137 | MP0003699_abnormal_female_reproductive | 0.52313994 |
| 138 | MP0004264_abnormal_extraembryonic_tissu | 0.52037935 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Reticulocytopenia (HP:0001896) | 4.51688770 |
| 2 | Birth length less than 3rd percentile (HP:0003561) | 4.51511169 |
| 3 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.11204871 |
| 4 | Abnormal number of erythroid precursors (HP:0012131) | 4.02625923 |
| 5 | Chromsome breakage (HP:0040012) | 3.92839873 |
| 6 | Breast hypoplasia (HP:0003187) | 3.84063846 |
| 7 | Carpal bone hypoplasia (HP:0001498) | 3.64608819 |
| 8 | Degeneration of anterior horn cells (HP:0002398) | 3.63855844 |
| 9 | Abnormality of the anterior horn cell (HP:0006802) | 3.63855844 |
| 10 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.60012148 |
| 11 | Patellar aplasia (HP:0006443) | 3.39088375 |
| 12 | Oral leukoplakia (HP:0002745) | 3.32768333 |
| 13 | Selective tooth agenesis (HP:0001592) | 3.27694569 |
| 14 | Colon cancer (HP:0003003) | 3.24665576 |
| 15 | Aplasia/Hypoplasia of the patella (HP:0006498) | 3.24284365 |
| 16 | Meckel diverticulum (HP:0002245) | 3.19624975 |
| 17 | Aplastic anemia (HP:0001915) | 3.17321578 |
| 18 | Cortical dysplasia (HP:0002539) | 3.16437912 |
| 19 | Abnormality of chromosome stability (HP:0003220) | 3.11553445 |
| 20 | Abnormality of the preputium (HP:0100587) | 3.07269538 |
| 21 | Impulsivity (HP:0100710) | 3.07015413 |
| 22 | Abnormality of the ileum (HP:0001549) | 3.01528910 |
| 23 | Medulloblastoma (HP:0002885) | 2.99645727 |
| 24 | Myelodysplasia (HP:0002863) | 2.96233473 |
| 25 | Small intestinal stenosis (HP:0012848) | 2.94184190 |
| 26 | Duodenal stenosis (HP:0100867) | 2.94184190 |
| 27 | 11 pairs of ribs (HP:0000878) | 2.92556320 |
| 28 | Abnormal lung lobation (HP:0002101) | 2.86059960 |
| 29 | Pallor (HP:0000980) | 2.82684732 |
| 30 | Absent thumb (HP:0009777) | 2.82550050 |
| 31 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.77086660 |
| 32 | Macrocytic anemia (HP:0001972) | 2.66263616 |
| 33 | Sloping forehead (HP:0000340) | 2.65060884 |
| 34 | Absent radius (HP:0003974) | 2.58908047 |
| 35 | Rough bone trabeculation (HP:0100670) | 2.57828339 |
| 36 | Agnosia (HP:0010524) | 2.55719530 |
| 37 | Increased nuchal translucency (HP:0010880) | 2.53340558 |
| 38 | Ependymoma (HP:0002888) | 2.52748952 |
| 39 | Bone marrow hypocellularity (HP:0005528) | 2.50951108 |
| 40 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.49667618 |
| 41 | Rhabdomyosarcoma (HP:0002859) | 2.48186814 |
| 42 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.47089350 |
| 43 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.46825601 |
| 44 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 2.41882494 |
| 45 | Thrombocytosis (HP:0001894) | 2.41554833 |
| 46 | Neoplasm of the pancreas (HP:0002894) | 2.39966619 |
| 47 | Aplasia involving forearm bones (HP:0009822) | 2.38568264 |
| 48 | Absent forearm bone (HP:0003953) | 2.38568264 |
| 49 | Abnormality of the duodenum (HP:0002246) | 2.36206045 |
| 50 | Septo-optic dysplasia (HP:0100842) | 2.34000870 |
| 51 | Basal cell carcinoma (HP:0002671) | 2.30825884 |
| 52 | Horseshoe kidney (HP:0000085) | 2.28086155 |
| 53 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.26748994 |
| 54 | Premature graying of hair (HP:0002216) | 2.26465973 |
| 55 | Hypoplastic pelvis (HP:0008839) | 2.25775765 |
| 56 | Absent septum pellucidum (HP:0001331) | 2.24758746 |
| 57 | Microretrognathia (HP:0000308) | 2.24533187 |
| 58 | Embryonal neoplasm (HP:0002898) | 2.23734683 |
| 59 | Ectopic kidney (HP:0000086) | 2.23184585 |
| 60 | Trismus (HP:0000211) | 2.19847121 |
| 61 | Microvesicular hepatic steatosis (HP:0001414) | 2.19321015 |
| 62 | Supernumerary spleens (HP:0009799) | 2.16755149 |
| 63 | Atresia of the external auditory canal (HP:0000413) | 2.14585203 |
| 64 | Abnormality of reticulocytes (HP:0004312) | 2.14539118 |
| 65 | Tracheoesophageal fistula (HP:0002575) | 2.14478418 |
| 66 | Abnormality of the septum pellucidum (HP:0007375) | 2.13583004 |
| 67 | Neoplasm of the colon (HP:0100273) | 2.13337278 |
| 68 | Cellular immunodeficiency (HP:0005374) | 2.12877222 |
| 69 | Cleft eyelid (HP:0000625) | 2.11374465 |
| 70 | Multiple enchondromatosis (HP:0005701) | 2.10628233 |
| 71 | Abnormality of glycolysis (HP:0004366) | 2.10394201 |
| 72 | Triphalangeal thumb (HP:0001199) | 2.09882795 |
| 73 | Proximal placement of thumb (HP:0009623) | 2.09458405 |
| 74 | Embryonal renal neoplasm (HP:0011794) | 2.08948967 |
| 75 | Cafe-au-lait spot (HP:0000957) | 2.08537120 |
| 76 | Cerebral hypomyelination (HP:0006808) | 2.08457388 |
| 77 | Duplicated collecting system (HP:0000081) | 2.07836011 |
| 78 | Abnormal number of incisors (HP:0011064) | 2.07633111 |
| 79 | Increased serum pyruvate (HP:0003542) | 2.06366131 |
| 80 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 2.06169100 |
| 81 | Deviation of the thumb (HP:0009603) | 2.04569832 |
| 82 | Acute encephalopathy (HP:0006846) | 2.03892252 |
| 83 | Choanal atresia (HP:0000453) | 2.02571573 |
| 84 | Acute necrotizing encephalopathy (HP:0006965) | 2.00498269 |
| 85 | Squamous cell carcinoma (HP:0002860) | 1.99144417 |
| 86 | High pitched voice (HP:0001620) | 1.99113472 |
| 87 | Missing ribs (HP:0000921) | 1.99103061 |
| 88 | Increased hepatocellular lipid droplets (HP:0006565) | 1.98814792 |
| 89 | Duplication of thumb phalanx (HP:0009942) | 1.97335793 |
| 90 | Premature ovarian failure (HP:0008209) | 1.97287676 |
| 91 | Prominent nose (HP:0000448) | 1.96793692 |
| 92 | Abnormality of the labia minora (HP:0012880) | 1.93259211 |
| 93 | Lymphoma (HP:0002665) | 1.91396630 |
| 94 | Abnormality of the carotid arteries (HP:0005344) | 1.89670360 |
| 95 | Short thumb (HP:0009778) | 1.89596571 |
| 96 | Secondary amenorrhea (HP:0000869) | 1.85179353 |
| 97 | Abnormal mitochondria in muscle tissue (HP:0008316) | 1.84212329 |
| 98 | Volvulus (HP:0002580) | 1.83217992 |
| 99 | Short 4th metacarpal (HP:0010044) | 1.82395132 |
| 100 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 1.82395132 |
| 101 | Clubbing of toes (HP:0100760) | 1.82165308 |
| 102 | Amaurosis fugax (HP:0100576) | 1.81833847 |
| 103 | Abnormality of the renal collecting system (HP:0004742) | 1.80992238 |
| 104 | Glioma (HP:0009733) | 1.80912157 |
| 105 | Abnormal trabecular bone morphology (HP:0100671) | 1.79703799 |
| 106 | Facial cleft (HP:0002006) | 1.78810504 |
| 107 | Pancytopenia (HP:0001876) | 1.78050863 |
| 108 | Optic nerve coloboma (HP:0000588) | 1.77930740 |
| 109 | Broad distal phalanx of finger (HP:0009836) | 1.77461786 |
| 110 | Ovarian neoplasm (HP:0100615) | 1.77108966 |
| 111 | Oligodactyly (HP:0012165) | 1.77032845 |
| 112 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 1.76254352 |
| 113 | Absent epiphyses (HP:0010577) | 1.76254352 |
| 114 | Median cleft lip (HP:0000161) | 1.75733930 |
| 115 | Cholecystitis (HP:0001082) | 1.75678295 |
| 116 | Abnormal gallbladder physiology (HP:0012438) | 1.75678295 |
| 117 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 1.75592899 |
| 118 | Lipid accumulation in hepatocytes (HP:0006561) | 1.75409787 |
| 119 | Oligodactyly (hands) (HP:0001180) | 1.74639668 |
| 120 | Short middle phalanx of the 5th finger (HP:0004220) | 1.74264779 |
| 121 | Increased CSF lactate (HP:0002490) | 1.73971238 |
| 122 | High anterior hairline (HP:0009890) | 1.73861456 |
| 123 | Type I transferrin isoform profile (HP:0003642) | 1.73627343 |
| 124 | IgM deficiency (HP:0002850) | 1.73451936 |
| 125 | Irregular epiphyses (HP:0010582) | 1.73435412 |
| 126 | Facial hemangioma (HP:0000329) | 1.72691410 |
| 127 | Holoprosencephaly (HP:0001360) | 1.72343951 |
| 128 | Abnormality of abdominal situs (HP:0011620) | 1.72075189 |
| 129 | Abdominal situs inversus (HP:0003363) | 1.72075189 |
| 130 | Hyperglycinemia (HP:0002154) | 1.68518399 |
| 131 | Hemivertebrae (HP:0002937) | 1.66037665 |
| 132 | Abnormality of chromosome segregation (HP:0002916) | 1.66023272 |
| 133 | Arteriovenous malformation (HP:0100026) | 1.65973992 |
| 134 | Abnormality of cochlea (HP:0000375) | 1.65012460 |
| 135 | Preaxial hand polydactyly (HP:0001177) | 1.64194332 |
| 136 | Mitochondrial inheritance (HP:0001427) | 1.63452017 |
| 137 | Stenosis of the external auditory canal (HP:0000402) | 1.62325582 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 5.93512915 |
| 2 | WEE1 | 4.35113847 |
| 3 | CDC7 | 3.96361880 |
| 4 | NEK2 | 3.49890313 |
| 5 | EIF2AK1 | 3.04748276 |
| 6 | VRK2 | 2.76869203 |
| 7 | TTK | 2.70812639 |
| 8 | BRSK2 | 2.60266631 |
| 9 | NEK1 | 2.32392157 |
| 10 | TESK2 | 2.26082154 |
| 11 | PLK1 | 2.19953745 |
| 12 | SRPK1 | 2.12147743 |
| 13 | PLK4 | 2.07705585 |
| 14 | AURKB | 1.95129263 |
| 15 | NME2 | 1.86857444 |
| 16 | ACVR1B | 1.81102600 |
| 17 | BRSK1 | 1.80349604 |
| 18 | TLK1 | 1.79031051 |
| 19 | VRK1 | 1.74116487 |
| 20 | STK10 | 1.69687016 |
| 21 | STK16 | 1.63079916 |
| 22 | PLK3 | 1.56000752 |
| 23 | ATR | 1.55143550 |
| 24 | MKNK1 | 1.54929239 |
| 25 | EIF2AK3 | 1.54310797 |
| 26 | AURKA | 1.52731615 |
| 27 | CDK7 | 1.52597753 |
| 28 | MAP3K8 | 1.50914862 |
| 29 | RPS6KB2 | 1.48151456 |
| 30 | STK4 | 1.46711746 |
| 31 | CHEK2 | 1.46524351 |
| 32 | CCNB1 | 1.45909728 |
| 33 | RPS6KA4 | 1.45635033 |
| 34 | TSSK6 | 1.39891865 |
| 35 | PASK | 1.38126795 |
| 36 | EEF2K | 1.37633816 |
| 37 | SCYL2 | 1.36295592 |
| 38 | TRIM28 | 1.35276437 |
| 39 | CDK12 | 1.33705286 |
| 40 | CDK4 | 1.27743802 |
| 41 | DYRK3 | 1.25596233 |
| 42 | TESK1 | 1.24683080 |
| 43 | NUAK1 | 1.17339629 |
| 44 | PAK4 | 1.16389425 |
| 45 | TAF1 | 1.15745282 |
| 46 | MAP3K10 | 1.14394284 |
| 47 | CHEK1 | 1.12114218 |
| 48 | MKNK2 | 1.09669241 |
| 49 | KDR | 1.05168270 |
| 50 | PBK | 1.02947125 |
| 51 | TGFBR1 | 0.96398317 |
| 52 | NME1 | 0.93849490 |
| 53 | ZAK | 0.89137966 |
| 54 | MAP4K1 | 0.88214981 |
| 55 | EPHA2 | 0.85380872 |
| 56 | EIF2AK2 | 0.83926018 |
| 57 | BRAF | 0.83824831 |
| 58 | FLT3 | 0.83057903 |
| 59 | ATM | 0.82780146 |
| 60 | PKN2 | 0.82685785 |
| 61 | PIM1 | 0.75806718 |
| 62 | CDK2 | 0.74251127 |
| 63 | PAK1 | 0.73518605 |
| 64 | CDK6 | 0.71631967 |
| 65 | CLK1 | 0.71014251 |
| 66 | MELK | 0.69314128 |
| 67 | LRRK2 | 0.69301464 |
| 68 | WNK3 | 0.68880106 |
| 69 | PDK2 | 0.67226552 |
| 70 | CDK1 | 0.60912476 |
| 71 | STK3 | 0.59815685 |
| 72 | CSNK2A1 | 0.59785155 |
| 73 | CDK8 | 0.58892293 |
| 74 | TNIK | 0.57551027 |
| 75 | PIM2 | 0.53787041 |
| 76 | CSNK2A2 | 0.53558753 |
| 77 | MAPKAPK3 | 0.50593895 |
| 78 | UHMK1 | 0.50518853 |
| 79 | SMG1 | 0.48284317 |
| 80 | CDK19 | 0.47618106 |
| 81 | PDK3 | 0.46167045 |
| 82 | PDK4 | 0.46167045 |
| 83 | ZAP70 | 0.45690171 |
| 84 | BTK | 0.45299092 |
| 85 | MAP3K11 | 0.44483165 |
| 86 | RPS6KA5 | 0.43917053 |
| 87 | PLK2 | 0.42087619 |
| 88 | PRKCI | 0.41468169 |
| 89 | MAP2K3 | 0.41206432 |
| 90 | GRK6 | 0.38575764 |
| 91 | BMPR1B | 0.37952496 |
| 92 | ILK | 0.36412188 |
| 93 | ALK | 0.35872824 |
| 94 | ERBB4 | 0.35808623 |
| 95 | CDK14 | 0.34773289 |
| 96 | MARK3 | 0.34080580 |
| 97 | BCR | 0.33239756 |
| 98 | DYRK2 | 0.31358681 |
| 99 | CDK9 | 0.31251527 |
| 100 | BRD4 | 0.30871005 |
| 101 | PNCK | 0.30361040 |
| 102 | MET | 0.29778360 |
| 103 | CDK3 | 0.28970147 |
| 104 | MST4 | 0.27924928 |
| 105 | BCKDK | 0.27846050 |
| 106 | AKT2 | 0.27653460 |
| 107 | MINK1 | 0.27153078 |
| 108 | TEC | 0.26659718 |
| 109 | PRKDC | 0.26243063 |
| 110 | CSNK1G1 | 0.26032531 |
| 111 | CSNK1E | 0.25647224 |
| 112 | FGFR1 | 0.24469314 |
| 113 | MAPKAPK2 | 0.23424796 |
| 114 | BLK | 0.23413820 |
| 115 | MST1R | 0.23375077 |
| 116 | MAPK11 | 0.23057934 |
| 117 | LIMK1 | 0.21669578 |
| 118 | NEK9 | 0.20807278 |
| 119 | JAK3 | 0.19813578 |
| 120 | TAOK2 | 0.19262357 |
| 121 | CDK11A | 0.19008901 |
| 122 | STK38L | 0.18953377 |
| 123 | RAF1 | 0.18324347 |
| 124 | KSR1 | 0.17840764 |
| 125 | LYN | 0.16853496 |
| 126 | PKN1 | 0.16027220 |
| 127 | CDK15 | 0.15826676 |
| 128 | STK24 | 0.14983637 |
| 129 | LATS1 | 0.14944836 |
| 130 | MAPK14 | 0.14387470 |
| 131 | CSNK1G3 | 0.14114148 |
| 132 | EPHB2 | 0.14111161 |
| 133 | MTOR | 0.13973600 |
| 134 | CDK18 | 0.13885383 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 5.09633160 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 4.27775931 |
| 3 | Ribosome_Homo sapiens_hsa03010 | 3.45292597 |
| 4 | Spliceosome_Homo sapiens_hsa03040 | 3.31283879 |
| 5 | Base excision repair_Homo sapiens_hsa03410 | 3.28715969 |
| 6 | Homologous recombination_Homo sapiens_hsa03440 | 3.26779308 |
| 7 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.25986835 |
| 8 | Proteasome_Homo sapiens_hsa03050 | 3.19584130 |
| 9 | * Cell cycle_Homo sapiens_hsa04110 | 3.07600535 |
| 10 | RNA transport_Homo sapiens_hsa03013 | 3.04294734 |
| 11 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.89043199 |
| 12 | RNA polymerase_Homo sapiens_hsa03020 | 2.70945351 |
| 13 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.36304755 |
| 14 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.35866539 |
| 15 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.32720603 |
| 16 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.32414208 |
| 17 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.31388778 |
| 18 | Basal transcription factors_Homo sapiens_hsa03022 | 1.99005908 |
| 19 | RNA degradation_Homo sapiens_hsa03018 | 1.97451114 |
| 20 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.76174483 |
| 21 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.60960690 |
| 22 | * p53 signaling pathway_Homo sapiens_hsa04115 | 1.60201664 |
| 23 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.42164739 |
| 24 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.33579023 |
| 25 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.31958503 |
| 26 | * Oocyte meiosis_Homo sapiens_hsa04114 | 1.25046294 |
| 27 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.23521039 |
| 28 | Purine metabolism_Homo sapiens_hsa00230 | 1.19730858 |
| 29 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.15901358 |
| 30 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.14086146 |
| 31 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.13397002 |
| 32 | * Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.07996762 |
| 33 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.06314501 |
| 34 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.06133040 |
| 35 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.02462608 |
| 36 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.01396828 |
| 37 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.00924749 |
| 38 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.98667939 |
| 39 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.95968447 |
| 40 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.79605381 |
| 41 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.78739453 |
| 42 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.78387760 |
| 43 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.77465395 |
| 44 | * HTLV-I infection_Homo sapiens_hsa05166 | 0.76062245 |
| 45 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.75603215 |
| 46 | Alzheimers disease_Homo sapiens_hsa05010 | 0.74734832 |
| 47 | Protein export_Homo sapiens_hsa03060 | 0.72175946 |
| 48 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.71985376 |
| 49 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.69981699 |
| 50 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.68294334 |
| 51 | Thyroid cancer_Homo sapiens_hsa05216 | 0.67477347 |
| 52 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.64105806 |
| 53 | Legionellosis_Homo sapiens_hsa05134 | 0.63921138 |
| 54 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.61710140 |
| 55 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.61472565 |
| 56 | Huntingtons disease_Homo sapiens_hsa05016 | 0.60818727 |
| 57 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.60652293 |
| 58 | Alcoholism_Homo sapiens_hsa05034 | 0.60502995 |
| 59 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.59692783 |
| 60 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.59386683 |
| 61 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.58129152 |
| 62 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.56564976 |
| 63 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.55311995 |
| 64 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.55119733 |
| 65 | Apoptosis_Homo sapiens_hsa04210 | 0.49989463 |
| 66 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.49376604 |
| 67 | Carbon metabolism_Homo sapiens_hsa01200 | 0.49069690 |
| 68 | Lysine degradation_Homo sapiens_hsa00310 | 0.47808918 |
| 69 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.46857293 |
| 70 | Shigellosis_Homo sapiens_hsa05131 | 0.45587660 |
| 71 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.44995653 |
| 72 | Sulfur relay system_Homo sapiens_hsa04122 | 0.44566054 |
| 73 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.43604558 |
| 74 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.43240090 |
| 75 | Measles_Homo sapiens_hsa05162 | 0.40440119 |
| 76 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.39996195 |
| 77 | Parkinsons disease_Homo sapiens_hsa05012 | 0.39521675 |
| 78 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.39391384 |
| 79 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.38704833 |
| 80 | Hepatitis B_Homo sapiens_hsa05161 | 0.37299564 |
| 81 | Colorectal cancer_Homo sapiens_hsa05210 | 0.36087218 |
| 82 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.33739797 |
| 83 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.32275368 |
| 84 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.32233201 |
| 85 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.31090272 |
| 86 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.30991986 |
| 87 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.30113595 |
| 88 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.30006702 |
| 89 | Adherens junction_Homo sapiens_hsa04520 | 0.28839021 |
| 90 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.27894516 |
| 91 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.26991303 |
| 92 | Influenza A_Homo sapiens_hsa05164 | 0.26675473 |
| 93 | Bladder cancer_Homo sapiens_hsa05219 | 0.26619340 |
| 94 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.26447833 |
| 95 | Viral myocarditis_Homo sapiens_hsa05416 | 0.25222119 |
| 96 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.24706740 |
| 97 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.22346712 |
| 98 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.22192914 |
| 99 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.21798196 |
| 100 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.21753972 |
| 101 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.21723354 |
| 102 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.21651754 |
| 103 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.21277080 |
| 104 | Asthma_Homo sapiens_hsa05310 | 0.20573577 |
| 105 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.20439317 |
| 106 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.20147318 |
| 107 | Pathways in cancer_Homo sapiens_hsa05200 | 0.19576884 |
| 108 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.19115088 |
| 109 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.19112667 |
| 110 | Galactose metabolism_Homo sapiens_hsa00052 | 0.18513762 |
| 111 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.18092294 |
| 112 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.17261226 |
| 113 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.15680320 |
| 114 | Leishmaniasis_Homo sapiens_hsa05140 | 0.14550174 |
| 115 | Metabolic pathways_Homo sapiens_hsa01100 | 0.14160617 |
| 116 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.13540163 |
| 117 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.13295468 |
| 118 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.13050212 |
| 119 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.12242547 |
| 120 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.12121706 |
| 121 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.11456673 |
| 122 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.10522606 |
| 123 | Peroxisome_Homo sapiens_hsa04146 | 0.10199095 |
| 124 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.09172180 |
| 125 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.08085666 |
| 126 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.06964011 |
| 127 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.06702235 |
| 128 | Prostate cancer_Homo sapiens_hsa05215 | 0.06561186 |
| 129 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.06230575 |
| 130 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.04728253 |
| 131 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.03926852 |

