ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cornea development in camera-type eye (GO:0061303)	5.53777726
2	alkaloid metabolic process (GO:0009820)	5.42632980
3	glial cell proliferation (GO:0014009)	5.24380641
4	regulation of hippo signaling (GO:0035330)	5.09633854
5	high-density lipoprotein particle remodeling (GO:0034375)	5.04611639
6	somite rostral/caudal axis specification (GO:0032525)	5.04073772
7	sympathetic nervous system development (GO:0048485)	5.03818015
8	water-soluble vitamin biosynthetic process (GO:0042364)	4.90850672
9	limb bud formation (GO:0060174)	4.85468152
10	keratinocyte development (GO:0003334)	4.79383259
11	positive regulation of histone H3-K4 methylation (GO:0051571)	4.68703898
12	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	4.65852330
13	cellular ketone body metabolic process (GO:0046950)	4.63331244
14	prenylation (GO:0097354)	4.63302337
15	protein prenylation (GO:0018342)	4.63302337
16	phospholipid efflux (GO:0033700)	4.51593291
17	regulation of cholesterol esterification (GO:0010872)	4.47145338
18	reverse cholesterol transport (GO:0043691)	4.34214034
19	DNA double-strand break processing (GO:0000729)	4.32949111
20	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	4.31570183
21	regulation of male gonad development (GO:2000018)	4.30194273
22	regulation of DNA endoreduplication (GO:0032875)	4.22036287
23	fatty acid elongation (GO:0030497)	4.17193498
24	phospholipid homeostasis (GO:0055091)	4.17007934
25	ketone body metabolic process (GO:1902224)	4.16285646
26	negative regulation of transcription regulatory region DNA binding (GO:2000678)	4.16185965
27	serotonin receptor signaling pathway (GO:0007210)	4.14663548
28	platelet dense granule organization (GO:0060155)	4.04661001
29	neural tube formation (GO:0001841)	3.92784240
30	zinc ion transport (GO:0006829)	3.85380496
31	cardiac ventricle formation (GO:0003211)	3.73349969
32	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.65767833
33	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.65767833
34	regulation of translation, ncRNA-mediated (GO:0045974)	3.65767833
35	L-fucose metabolic process (GO:0042354)	3.58146063
36	L-fucose catabolic process (GO:0042355)	3.58146063
37	fucose catabolic process (GO:0019317)	3.58146063
38	regulation of heterotypic cell-cell adhesion (GO:0034114)	3.47969562
39	dentate gyrus development (GO:0021542)	3.41394033
40	somite development (GO:0061053)	3.41138907
41	cardiac chamber formation (GO:0003207)	3.40510464
42	endosome to melanosome transport (GO:0035646)	3.34692370
43	endosome to pigment granule transport (GO:0043485)	3.34692370
44	negative regulation of lipase activity (GO:0060192)	3.30895011
45	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.30030832
46	regulation of cytokine secretion involved in immune response (GO:0002739)	3.29705497
47	indolalkylamine metabolic process (GO:0006586)	3.28431165
48	regulation of cilium movement (GO:0003352)	3.26686571
49	cholesterol biosynthetic process (GO:0006695)	3.25578434
50	polyketide metabolic process (GO:0030638)	3.25035027
51	doxorubicin metabolic process (GO:0044598)	3.25035027
52	daunorubicin metabolic process (GO:0044597)	3.25035027
53	response to folic acid (GO:0051593)	3.19081840
54	auditory receptor cell differentiation (GO:0042491)	3.17074791
55	regulation of meiosis I (GO:0060631)	3.16118781
56	neurotransmitter-gated ion channel clustering (GO:0072578)	3.15865066
57	intra-Golgi vesicle-mediated transport (GO:0006891)	3.14926061
58	synaptic transmission, cholinergic (GO:0007271)	3.13706187
59	acrosome reaction (GO:0007340)	3.12924998
60	isoprenoid biosynthetic process (GO:0008299)	3.12872769
61	plasma lipoprotein particle assembly (GO:0034377)	3.02633600
62	renal tubule morphogenesis (GO:0061333)	3.02419115
63	cholesterol efflux (GO:0033344)	3.02079392
64	negative chemotaxis (GO:0050919)	2.91526884
65	plasma lipoprotein particle clearance (GO:0034381)	2.90640785
66	aminoglycoside antibiotic metabolic process (GO:0030647)	2.88061594
67	cell wall macromolecule catabolic process (GO:0016998)	2.87734535
68	triglyceride homeostasis (GO:0070328)	2.87714503
69	acylglycerol homeostasis (GO:0055090)	2.87714503
70	protein-lipid complex remodeling (GO:0034368)	2.87693242
71	macromolecular complex remodeling (GO:0034367)	2.87693242
72	plasma lipoprotein particle remodeling (GO:0034369)	2.87693242
73	long-chain fatty acid biosynthetic process (GO:0042759)	2.86214715
74	sterol biosynthetic process (GO:0016126)	2.85283464
75	spinal cord development (GO:0021510)	2.76697965
76	pyrimidine nucleobase catabolic process (GO:0006208)	2.76328352
77	positive regulation of meiosis (GO:0045836)	2.74182343
78	phasic smooth muscle contraction (GO:0014821)	2.73985680
79	central nervous system neuron axonogenesis (GO:0021955)	2.73108034
80	central nervous system projection neuron axonogenesis (GO:0021952)	2.73076141
81	detection of calcium ion (GO:0005513)	2.72738801
82	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.70413803
83	positive regulation of histone methylation (GO:0031062)	2.70357970
84	glycerophospholipid catabolic process (GO:0046475)	2.68920541
85	S-adenosylmethionine metabolic process (GO:0046500)	2.68573346
86	neuroepithelial cell differentiation (GO:0060563)	2.65583518
87	peristalsis (GO:0030432)	2.63221850
88	nephron epithelium morphogenesis (GO:0072088)	2.61983269
89	nephron tubule morphogenesis (GO:0072078)	2.61983269
90	phosphatidylcholine biosynthetic process (GO:0006656)	2.60808115
91	positive regulation of meiotic cell cycle (GO:0051446)	2.60310035
92	lipid particle organization (GO:0034389)	2.59207973
93	glutathione biosynthetic process (GO:0006750)	2.59054652
94	regulation of keratinocyte proliferation (GO:0010837)	2.58407848
95	amino-acid betaine transport (GO:0015838)	2.58022675
96	carnitine transport (GO:0015879)	2.58022675
97	axonal fasciculation (GO:0007413)	2.57611619
98	negative regulation of glial cell proliferation (GO:0060253)	2.54562488
99	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.54163473
100	histone H3-K4 trimethylation (GO:0080182)	2.53576879

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	7.50773862
2	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	5.16961025
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.89434558
4	VDR_22108803_ChIP-Seq_LS180_Human	3.49055915
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.93393632
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.87356556
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.70114397
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.56657051
9	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.54487879
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.47479592
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.35888540
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.29671999
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.27409550
14	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.27354194
15	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.23266565
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.05694354
17	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.99730325
18	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.89738653
19	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.89468443
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.88935731
21	P300_19829295_ChIP-Seq_ESCs_Human	1.85133606
22	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.82028663
23	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.73075712
24	FUS_26573619_Chip-Seq_HEK293_Human	1.72616617
25	HTT_18923047_ChIP-ChIP_STHdh_Human	1.72194817
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.70564949
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.67709188
28	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.62913926
29	SMAD4_21799915_ChIP-Seq_A2780_Human	1.62001796
30	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.61201205
31	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.61171181
32	EWS_26573619_Chip-Seq_HEK293_Human	1.58051135
33	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.53882402
34	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.48431724
35	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.46952914
36	BCAT_22108803_ChIP-Seq_LS180_Human	1.46729147
37	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.43327163
38	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.38813764
39	TCF4_23295773_ChIP-Seq_U87_Human	1.38581944
40	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.37886980
41	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.34997751
42	AR_25329375_ChIP-Seq_VCAP_Human	1.33972103
43	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.33306273
44	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.31775323
45	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.31379120
46	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.28391512
47	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.28161919
48	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.26619974
49	CBP_20019798_ChIP-Seq_JUKART_Human	1.26619974
50	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.25733221
51	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.25428138
52	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.24993456
53	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.24898978
54	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.21425425
55	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.19241367
56	STAT3_23295773_ChIP-Seq_U87_Human	1.18063422
57	TCF4_22108803_ChIP-Seq_LS180_Human	1.17914759
58	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.17157527
59	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.14338213
60	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.11009604
61	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.11004281
62	RUNX2_22187159_ChIP-Seq_PCA_Human	1.09468399
63	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.09237600
64	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.08960442
65	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.08721124
66	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.07995918
67	SOX2_19829295_ChIP-Seq_ESCs_Human	1.06944878
68	NANOG_19829295_ChIP-Seq_ESCs_Human	1.06944878
69	TP53_18474530_ChIP-ChIP_U2OS_Human	1.06760761
70	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.04682768
71	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.04090160
72	TP53_16413492_ChIP-PET_HCT116_Human	1.03323560
73	CJUN_26792858_Chip-Seq_BT549_Human	1.02926692
74	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.99947218
75	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.99328656
76	CDX2_22108803_ChIP-Seq_LS180_Human	0.99266036
77	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.97984594
78	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.94327703
79	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.94327703
80	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.93443799
81	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.92990244
82	TP53_22573176_ChIP-Seq_HFKS_Human	0.92668845
83	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.92155881
84	ELK1_19687146_ChIP-ChIP_HELA_Human	0.91488747
85	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.91425101
86	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.91330608
87	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.91245564
88	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.90912448
89	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.90747663
90	KDM2B_26808549_Chip-Seq_REH_Human	0.89705293
91	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.89203696
92	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.89203696
93	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.88472316
94	JUN_21703547_ChIP-Seq_K562_Human	0.87455450
95	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.87321644
96	P53_22387025_ChIP-Seq_ESCs_Mouse	0.86791535
97	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.86646027
98	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.86455463
99	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.86393255
100	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.85691345

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009840_abnormal_foam_cell	5.06637466
2	MP0001529_abnormal_vocalization	3.93340436
3	MP0004134_abnormal_chest_morphology	3.83616156
4	MP0003122_maternal_imprinting	3.47792569
5	MP0003787_abnormal_imprinting	3.28138158
6	MP0003191_abnormal_cellular_cholesterol	3.26792432
7	MP0005379_endocrine/exocrine_gland_phen	3.15397243
8	MP0005646_abnormal_pituitary_gland	3.00311126
9	MP0008877_abnormal_DNA_methylation	2.86533899
10	MP0003880_abnormal_central_pattern	2.70593758
11	MP0002909_abnormal_adrenal_gland	2.60533997
12	MP0002102_abnormal_ear_morphology	2.36785989
13	MP0004043_abnormal_pH_regulation	2.30058015
14	MP0002837_dystrophic_cardiac_calcinosis	2.29598327
15	MP0003121_genomic_imprinting	2.24619471
16	MP0004381_abnormal_hair_follicle	2.14845104
17	MP0001944_abnormal_pancreas_morphology	2.12752428
18	MP0010329_abnormal_lipoprotein_level	2.07346298
19	MP0000015_abnormal_ear_pigmentation	2.06580237
20	MP0009697_abnormal_copulation	2.03047692
21	MP0004019_abnormal_vitamin_homeostasis	1.96613011
22	MP0005253_abnormal_eye_physiology	1.78179453
23	MP0003786_premature_aging	1.76178981
24	MP0000631_abnormal_neuroendocrine_gland	1.75832994
25	MP0005083_abnormal_biliary_tract	1.68038113
26	MP0002127_abnormal_cardiovascular_syste	1.64686698
27	MP0000372_irregular_coat_pigmentation	1.63789341
28	MP0003718_maternal_effect	1.62022280
29	MP0005551_abnormal_eye_electrophysiolog	1.56858345
30	MP0009046_muscle_twitch	1.55282497
31	MP0001188_hyperpigmentation	1.51683706
32	MP0004270_analgesia	1.45928943
33	MP0003646_muscle_fatigue	1.44452445
34	MP0003693_abnormal_embryo_hatching	1.44218542
35	MP0005174_abnormal_tail_pigmentation	1.43537130
36	MP0002751_abnormal_autonomic_nervous	1.40235705
37	MP0002733_abnormal_thermal_nociception	1.40083882
38	MP0004924_abnormal_behavior	1.38516841
39	MP0005386_behavior/neurological_phenoty	1.38516841
40	MP0000639_abnormal_adrenal_gland	1.36376806
41	MP0003195_calcinosis	1.34701045
42	MP0003123_paternal_imprinting	1.34635773
43	MP0003879_abnormal_hair_cell	1.32378039
44	MP0002184_abnormal_innervation	1.30259369
45	MP0004215_abnormal_myocardial_fiber	1.25436723
46	MP0000427_abnormal_hair_cycle	1.23686236
47	MP0005085_abnormal_gallbladder_physiolo	1.23366133
48	MP0002693_abnormal_pancreas_physiology	1.18952982
49	MP0005409_darkened_coat_color	1.18834508
50	MP0006276_abnormal_autonomic_nervous	1.18015962
51	MP0009745_abnormal_behavioral_response	1.17558980
52	MP0005645_abnormal_hypothalamus_physiol	1.12684047
53	MP0005075_abnormal_melanosome_morpholog	1.11756258
54	MP0000647_abnormal_sebaceous_gland	1.10714465
55	MP0005448_abnormal_energy_balance	1.10149406
56	MP0001243_abnormal_dermal_layer	1.07480870
57	MP0005395_other_phenotype	0.99788731
58	MP0002118_abnormal_lipid_homeostasis	0.99436954
59	MP0002078_abnormal_glucose_homeostasis	0.99222269
60	MP0000516_abnormal_urinary_system	0.95586221
61	MP0005367_renal/urinary_system_phenotyp	0.95586221
62	MP0009780_abnormal_chondrocyte_physiolo	0.95567006
63	MP0002163_abnormal_gland_morphology	0.94993318
64	MP0001970_abnormal_pain_threshold	0.94169146
65	MP0003868_abnormal_feces_composition	0.91640178
66	MP0002557_abnormal_social/conspecific_i	0.90733209
67	MP0004883_abnormal_blood_vessel	0.90595162
68	MP0003252_abnormal_bile_duct	0.89871292
69	MP0003953_abnormal_hormone_level	0.89157051
70	MP0001324_abnormal_eye_pigmentation	0.88903637
71	MP0000371_diluted_coat_color	0.87531562
72	MP0002229_neurodegeneration	0.87157006
73	MP0008875_abnormal_xenobiotic_pharmacok	0.86627615
74	MP0002254_reproductive_system_inflammat	0.85746360
75	MP0003136_yellow_coat_color	0.83886973
76	MP0008872_abnormal_physiological_respon	0.83196754
77	MP0005365_abnormal_bile_salt	0.82266427
78	MP0001764_abnormal_homeostasis	0.81666217
79	MP0001486_abnormal_startle_reflex	0.80851998
80	MP0005084_abnormal_gallbladder_morpholo	0.80406263
81	MP0001968_abnormal_touch/_nociception	0.79460485
82	MP0002876_abnormal_thyroid_physiology	0.77961020
83	MP0001485_abnormal_pinna_reflex	0.77346157
84	MP0000778_abnormal_nervous_system	0.75467705
85	MP0001905_abnormal_dopamine_level	0.74263738
86	MP0002272_abnormal_nervous_system	0.73111187
87	MP0003635_abnormal_synaptic_transmissio	0.73099492
88	MP0003283_abnormal_digestive_organ	0.71817088
89	MP0002095_abnormal_skin_pigmentation	0.70030701
90	MP0006072_abnormal_retinal_apoptosis	0.69974938
91	MP0000569_abnormal_digit_pigmentation	0.69914259
92	MP0009672_abnormal_birth_weight	0.69310613
93	MP0003137_abnormal_impulse_conducting	0.69136286
94	MP0002168_other_aberrant_phenotype	0.67431074
95	MP0000538_abnormal_urinary_bladder	0.67384076
96	MP0003941_abnormal_skin_development	0.65305478
97	MP0002090_abnormal_vision	0.64386152
98	MP0001943_abnormal_respiration	0.64159653
99	MP0004085_abnormal_heartbeat	0.63608619
100	MP0004147_increased_porphyrin_level	0.62466825

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the labia minora (HP:0012880)	6.89662542
2	Agitation (HP:0000713)	5.15106450
3	Methylmalonic acidemia (HP:0002912)	4.32637577
4	Congenital stationary night blindness (HP:0007642)	4.08204547
5	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	3.99372358
6	Conjugated hyperbilirubinemia (HP:0002908)	3.99207855
7	Hypoplastic ischia (HP:0003175)	3.89766301
8	Albinism (HP:0001022)	3.88022357
9	Absent/shortened dynein arms (HP:0200106)	3.80890579
10	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.80890579
11	Abnormality of lateral ventricle (HP:0030047)	3.69723710
12	Irregular vertebral endplates (HP:0003301)	3.39085682
13	Hyperglycinemia (HP:0002154)	3.39053698
14	Spontaneous abortion (HP:0005268)	3.35956063
15	Abnormality of vitamin B metabolism (HP:0004340)	3.30918433
16	Abnormality of the ischium (HP:0003174)	3.29287637
17	Volvulus (HP:0002580)	3.25789208
18	Heterotopia (HP:0002282)	3.23274122
19	Methylmalonic aciduria (HP:0012120)	3.07547081
20	Progressive inability to walk (HP:0002505)	2.88732295
21	Lissencephaly (HP:0001339)	2.87288682
22	Restlessness (HP:0000711)	2.84686139
23	Hip dysplasia (HP:0001385)	2.79322517
24	Hand muscle atrophy (HP:0009130)	2.72078187
25	Renal cortical cysts (HP:0000803)	2.69959038
26	Progressive microcephaly (HP:0000253)	2.67586581
27	Abnormality of the vertebral endplates (HP:0005106)	2.64254187
28	Hypoalphalipoproteinemia (HP:0003233)	2.63369522
29	Intestinal atresia (HP:0011100)	2.61730248
30	Hypolipoproteinemia (HP:0010981)	2.61726498
31	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.58213929
32	Patellar aplasia (HP:0006443)	2.56947302
33	Abnormality of the renal cortex (HP:0011035)	2.53495976
34	Ketoacidosis (HP:0001993)	2.46358317
35	Aplasia/Hypoplasia of the patella (HP:0006498)	2.42388501
36	Syncope (HP:0001279)	2.39106569
37	Abnormality of the pubic bones (HP:0003172)	2.37523886
38	Abnormal respiratory epithelium morphology (HP:0012253)	2.32655925
39	Abnormal respiratory motile cilium morphology (HP:0005938)	2.32655925
40	Abnormality of vitamin metabolism (HP:0100508)	2.28038228
41	Hyperventilation (HP:0002883)	2.27526023
42	Complete atrioventricular canal defect (HP:0001674)	2.27411227
43	Chronic hepatic failure (HP:0100626)	2.24907174
44	Abnormality of the nasal septum (HP:0000419)	2.22794020
45	Hypobetalipoproteinemia (HP:0003563)	2.19966447
46	Abnormality of the labia (HP:0000058)	2.17994386
47	Abnormal ciliary motility (HP:0012262)	2.17275551
48	Retinal atrophy (HP:0001105)	2.17241348
49	Slender build (HP:0001533)	2.16005245
50	Impulsivity (HP:0100710)	2.15045497
51	Focal motor seizures (HP:0011153)	2.14016905
52	Abnormal biliary tract morphology (HP:0012440)	2.11811447
53	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.10501796
54	Ketosis (HP:0001946)	2.09699438
55	Pancreatic cysts (HP:0001737)	2.08125883
56	Prominent supraorbital ridges (HP:0000336)	2.05602335
57	Neoplasm of the oral cavity (HP:0100649)	2.00401665
58	Hypothermia (HP:0002045)	1.98832040
59	Urethral obstruction (HP:0000796)	1.95602486
60	Small hand (HP:0200055)	1.95237631
61	Nephrocalcinosis (HP:0000121)	1.93859015
62	Increased nuchal translucency (HP:0010880)	1.92255392
63	Long clavicles (HP:0000890)	1.90833595
64	Chronic sinusitis (HP:0011109)	1.90806506
65	Hip contracture (HP:0003273)	1.90646148
66	Short 4th metacarpal (HP:0010044)	1.90424888
67	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	1.90424888
68	Flat capital femoral epiphysis (HP:0003370)	1.89923175
69	Inability to walk (HP:0002540)	1.89893725
70	Gaze-evoked nystagmus (HP:0000640)	1.89782336
71	Scrotal hypoplasia (HP:0000046)	1.88247908
72	Vascular calcification (HP:0004934)	1.87527119
73	Delayed closure of the anterior fontanelle (HP:0001476)	1.86711196
74	Atrioventricular canal defect (HP:0006695)	1.86130041
75	Abnormality of the clitoris (HP:0000056)	1.85245852
76	3-Methylglutaconic aciduria (HP:0003535)	1.84052027
77	Hyperphosphatemia (HP:0002905)	1.82924976
78	Furrowed tongue (HP:0000221)	1.82222746
79	Generalized hypopigmentation (HP:0007513)	1.80783974
80	Sloping forehead (HP:0000340)	1.79068247
81	Tubulointerstitial nephritis (HP:0001970)	1.78968779
82	Intellectual disability, progressive (HP:0006887)	1.77969622
83	Amyloidosis (HP:0011034)	1.77620992
84	EEG with generalized epileptiform discharges (HP:0011198)	1.77450024
85	Pancreatic fibrosis (HP:0100732)	1.77097278
86	Genetic anticipation (HP:0003743)	1.76205597
87	Abnormal respiratory motile cilium physiology (HP:0012261)	1.75620252
88	Atrial fibrillation (HP:0005110)	1.74631482
89	Abnormality of alanine metabolism (HP:0010916)	1.73722823
90	Hyperalaninemia (HP:0003348)	1.73722823
91	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.73722823
92	Rhinitis (HP:0012384)	1.73584976
93	Metaphyseal dysplasia (HP:0100255)	1.72437278
94	Epileptiform EEG discharges (HP:0011182)	1.72386115
95	Prominent nose (HP:0000448)	1.70928937
96	Distal upper limb amyotrophy (HP:0007149)	1.70837846
97	Upper limb amyotrophy (HP:0009129)	1.70837846
98	Neuroendocrine neoplasm (HP:0100634)	1.70371006
99	Widely spaced teeth (HP:0000687)	1.70209559
100	Hypsarrhythmia (HP:0002521)	1.70036221

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIM28	5.99436348
2	EPHA4	5.65550295
3	FRK	5.52583442
4	BUB1	4.84665442
5	PNCK	2.45493771
6	EEF2K	2.19866626
7	MAPKAPK3	2.04599802
8	ACVR1B	2.02540205
9	MAP3K12	1.93085981
10	GRK1	1.86254278
11	MST1R	1.74008441
12	PDK2	1.63313381
13	MKNK2	1.62753718
14	BMPR1B	1.61590860
15	EIF2AK1	1.59396659
16	EIF2AK3	1.58122589
17	NUAK1	1.55708511
18	CAMK1G	1.49832489
19	NTRK3	1.49033500
20	FGFR2	1.46604138
21	MAPK13	1.46322143
22	TRPM7	1.38964290
23	CDK8	1.31983378
24	AKT3	1.27919712
25	WNK4	1.23658072
26	FGFR3	1.16765437
27	MET	1.16319205
28	CASK	1.13979959
29	CDK19	1.12636710
30	MAPKAPK5	1.11739865
31	BCR	1.10082624
32	WNK3	1.09539370
33	PAK3	1.02947755
34	MARK1	1.01495475
35	OXSR1	0.99822348
36	INSRR	0.98878737
37	PTK2B	0.97657921
38	ADRBK2	0.94088307
39	MST4	0.91674358
40	TNK2	0.89614730
41	ERBB3	0.88191107
42	MYLK	0.86868009
43	PBK	0.85530622
44	STK38L	0.81857385
45	CAMK2D	0.78255990
46	PRKAA2	0.75703265
47	TEC	0.75297140
48	PLK1	0.72948850
49	RPS6KB2	0.70180854
50	YES1	0.68768854
51	PLK4	0.66392475
52	UHMK1	0.65715029
53	PLK3	0.63767441
54	BRSK2	0.62458197
55	MKNK1	0.61351406
56	EIF2AK2	0.60358808
57	RPS6KB1	0.59384339
58	PRKCG	0.59015364
59	PRKCE	0.55478300
60	MINK1	0.53282127
61	ATM	0.52723230
62	SIK3	0.51695202
63	MAPK8	0.49946819
64	PLK2	0.49775604
65	PHKG2	0.48289594
66	PHKG1	0.48289594
67	TGFBR1	0.48246699
68	FGFR1	0.46956752
69	PRKCB	0.46249133
70	STK39	0.43006665
71	CSNK1E	0.42443216
72	MAPK11	0.39459560
73	ROCK1	0.38518581
74	PRKDC	0.38295689
75	PRKCQ	0.37786476
76	PRKACB	0.37598338
77	CHEK1	0.37595604
78	PDK1	0.36389898
79	OBSCN	0.34554583
80	ERBB2	0.33906050
81	PRKG1	0.32916886
82	ADRBK1	0.31457105
83	PRKACA	0.31261139
84	MAP3K4	0.30707880
85	PINK1	0.30105347
86	VRK1	0.30098494
87	CSNK1D	0.29533368
88	CSF1R	0.28875417
89	PRKAA1	0.28425280
90	PRKCA	0.27650553
91	TXK	0.27623814
92	AKT2	0.27342966
93	STK4	0.26311363
94	CAMK1D	0.26024325
95	ILK	0.25420515
96	PDPK1	0.24576304
97	GSK3B	0.23588964
98	PRKG2	0.22365843
99	NEK1	0.21206207
100	MAP3K2	0.21168074

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.52930059
2	Sulfur metabolism_Homo sapiens_hsa00920	4.32166827
3	Butanoate metabolism_Homo sapiens_hsa00650	2.85300361
4	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.71278106
5	Steroid biosynthesis_Homo sapiens_hsa00100	2.70058037
6	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.51265041
7	Propanoate metabolism_Homo sapiens_hsa00640	2.43972899
8	Fatty acid elongation_Homo sapiens_hsa00062	2.43498871
9	Tryptophan metabolism_Homo sapiens_hsa00380	2.12422453
10	Selenocompound metabolism_Homo sapiens_hsa00450	2.08390287
11	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.97055735
12	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.78073896
13	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.72310813
14	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.69304725
15	Fatty acid metabolism_Homo sapiens_hsa01212	1.67650971
16	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.61803739
17	Nitrogen metabolism_Homo sapiens_hsa00910	1.60383716
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.58145068
19	Protein export_Homo sapiens_hsa03060	1.55363008
20	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.47162414
21	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.46760824
22	Fat digestion and absorption_Homo sapiens_hsa04975	1.43603166
23	Insulin secretion_Homo sapiens_hsa04911	1.40456235
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.31612396
25	Non-homologous end-joining_Homo sapiens_hsa03450	1.28251274
26	Folate biosynthesis_Homo sapiens_hsa00790	1.27803362
27	Sphingolipid metabolism_Homo sapiens_hsa00600	1.27361458
28	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.24193674
29	Basal transcription factors_Homo sapiens_hsa03022	1.20077038
30	Serotonergic synapse_Homo sapiens_hsa04726	1.15726641
31	PPAR signaling pathway_Homo sapiens_hsa03320	1.13560031
32	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.11228863
33	Circadian entrainment_Homo sapiens_hsa04713	1.10694073
34	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.06862701
35	Linoleic acid metabolism_Homo sapiens_hsa00591	1.05138693
36	Phototransduction_Homo sapiens_hsa04744	1.04496559
37	Renin secretion_Homo sapiens_hsa04924	1.01656056
38	Caffeine metabolism_Homo sapiens_hsa00232	1.00833391
39	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.00021390
40	Glycerolipid metabolism_Homo sapiens_hsa00561	0.97318079
41	Taste transduction_Homo sapiens_hsa04742	0.96054885
42	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.94512982
43	African trypanosomiasis_Homo sapiens_hsa05143	0.94237968
44	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.93819987
45	Glutathione metabolism_Homo sapiens_hsa00480	0.92473742
46	Peroxisome_Homo sapiens_hsa04146	0.90019407
47	Long-term depression_Homo sapiens_hsa04730	0.89372475
48	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.89083307
49	Dopaminergic synapse_Homo sapiens_hsa04728	0.89070030
50	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.86749598
51	Oocyte meiosis_Homo sapiens_hsa04114	0.86088835
52	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.85846495
53	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.85129050
54	Ether lipid metabolism_Homo sapiens_hsa00565	0.83088600
55	Nicotine addiction_Homo sapiens_hsa05033	0.82436024
56	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.79462290
57	Collecting duct acid secretion_Homo sapiens_hsa04966	0.79035304
58	Retinol metabolism_Homo sapiens_hsa00830	0.78854352
59	Fatty acid degradation_Homo sapiens_hsa00071	0.77329202
60	Chemical carcinogenesis_Homo sapiens_hsa05204	0.76523439
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.73828176
62	Fanconi anemia pathway_Homo sapiens_hsa03460	0.73660947
63	Glutamatergic synapse_Homo sapiens_hsa04724	0.73186519
64	Arginine biosynthesis_Homo sapiens_hsa00220	0.72176869
65	Oxidative phosphorylation_Homo sapiens_hsa00190	0.67995039
66	ABC transporters_Homo sapiens_hsa02010	0.67780155
67	Cholinergic synapse_Homo sapiens_hsa04725	0.66799825
68	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.66594269
69	Parkinsons disease_Homo sapiens_hsa05012	0.66079381
70	cAMP signaling pathway_Homo sapiens_hsa04024	0.65958172
71	Glucagon signaling pathway_Homo sapiens_hsa04922	0.62615924
72	Complement and coagulation cascades_Homo sapiens_hsa04610	0.60901929
73	RNA degradation_Homo sapiens_hsa03018	0.59342728
74	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.59333256
75	GABAergic synapse_Homo sapiens_hsa04727	0.59177434
76	Calcium signaling pathway_Homo sapiens_hsa04020	0.58446370
77	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.57780007
78	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.57723435
79	Amphetamine addiction_Homo sapiens_hsa05031	0.57643253
80	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.57089125
81	Cardiac muscle contraction_Homo sapiens_hsa04260	0.56597266
82	Metabolic pathways_Homo sapiens_hsa01100	0.55895599
83	Gastric acid secretion_Homo sapiens_hsa04971	0.54216095
84	Huntingtons disease_Homo sapiens_hsa05016	0.53855943
85	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.49852873
86	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.48106483
87	Circadian rhythm_Homo sapiens_hsa04710	0.47631066
88	RNA transport_Homo sapiens_hsa03013	0.46651134
89	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.46111844
90	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.45531568
91	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.44536097
92	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.42936712
93	Morphine addiction_Homo sapiens_hsa05032	0.40468982
94	RNA polymerase_Homo sapiens_hsa03020	0.38428470
95	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.32343722
96	Pyruvate metabolism_Homo sapiens_hsa00620	0.31738453
97	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.31646560
98	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.31046697
99	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.30493817
100	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.30284745

CCNB2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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