CCNB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as positive regulators of cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle. Different cyclins exhibit distinct expression and degradation patterns, which contribute to the temporal coordination of each mitotic event. Studies of similar genes in chicken and drosophila suggest that this cyclin may associate with CDC2 and CDK2 kinases, and may be required for proper spindle reorganization and restoration of the interphase nucleus. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA methylation involved in gamete generation (GO:0043046)9.85128019
2regulation of acrosome reaction (GO:0060046)9.37159488
3male meiosis (GO:0007140)8.26192550
4synapsis (GO:0007129)8.08761150
5regulation of meiosis I (GO:0060631)7.88888451
6synaptonemal complex assembly (GO:0007130)7.80305888
7synaptonemal complex organization (GO:0070193)7.22078108
8oocyte development (GO:0048599)6.86737898
9regulation of histone H3-K9 methylation (GO:0051570)6.35192316
10protein kinase C signaling (GO:0070528)5.98578152
11female gamete generation (GO:0007292)5.93361642
12mitotic chromosome condensation (GO:0007076)5.86642584
13mitotic metaphase plate congression (GO:0007080)5.80312989
14meiotic nuclear division (GO:0007126)5.77105960
15binding of sperm to zona pellucida (GO:0007339)5.75564672
16male meiosis I (GO:0007141)5.72782448
17negative regulation of reproductive process (GO:2000242)5.67247532
18DNA alkylation (GO:0006305)5.61177794
19DNA methylation (GO:0006306)5.61177794
20negative regulation of meiosis (GO:0045835)5.56381202
21chromosome organization involved in meiosis (GO:0070192)5.53003760
22* meiotic cell cycle (GO:0051321)5.42133141
23metaphase plate congression (GO:0051310)5.39516075
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.36912992
25gene silencing by RNA (GO:0031047)5.30974169
26attachment of spindle microtubules to kinetochore (GO:0008608)5.28783822
27meiotic chromosome segregation (GO:0045132)5.22689636
28regulation of meiosis (GO:0040020)5.22429881
29kinetochore organization (GO:0051383)5.19586415
30reproduction (GO:0000003)5.17807351
31oogenesis (GO:0048477)5.16933627
32kinetochore assembly (GO:0051382)5.15449182
33positive regulation of humoral immune response (GO:0002922)5.14824284
34positive regulation of histone H3-K4 methylation (GO:0051571)5.12903848
35retinal cone cell development (GO:0046549)5.11867165
36oocyte maturation (GO:0001556)4.94374687
37meiosis I (GO:0007127)4.84237205
38fertilization (GO:0009566)4.78312940
39meiotic cell cycle process (GO:1903046)4.68635515
40establishment of chromosome localization (GO:0051303)4.68328104
41negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.62905951
42negative regulation of histone methylation (GO:0031061)4.60915295
43regulation of steroid hormone secretion (GO:2000831)4.52633401
44positive regulation of meiosis (GO:0045836)4.48315840
45sperm-egg recognition (GO:0035036)4.44992792
46mitotic sister chromatid segregation (GO:0000070)4.43369284
47citrulline biosynthetic process (GO:0019240)4.41163428
48DNA damage induced protein phosphorylation (GO:0006975)4.34783007
49regulation of female gonad development (GO:2000194)4.34263943
50positive regulation of meiotic cell cycle (GO:0051446)4.29521229
51histone H3-K9 demethylation (GO:0033169)4.21127592
52DNA synthesis involved in DNA repair (GO:0000731)4.19638232
53sister chromatid cohesion (GO:0007062)4.18177394
54regulation of DNA methylation (GO:0044030)4.17890655
55DNA replication checkpoint (GO:0000076)4.16282051
56monoubiquitinated protein deubiquitination (GO:0035520)4.15653091
57DNA methylation or demethylation (GO:0044728)4.14507668
58regulation of meiotic cell cycle (GO:0051445)4.11222777
59histone H2A monoubiquitination (GO:0035518)4.10248691
60interkinetic nuclear migration (GO:0022027)4.08910819
61regulation of cell maturation (GO:1903429)4.02758342
62centriole replication (GO:0007099)4.01941996
63protein localization to kinetochore (GO:0034501)3.98829346
64spindle checkpoint (GO:0031577)3.89267833
65single fertilization (GO:0007338)3.88810735
66protein localization to chromosome, centromeric region (GO:0071459)3.86091784
67regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.85081764
68female gonad development (GO:0008585)3.84340142
69chromosome segregation (GO:0007059)3.80386804
70histone exchange (GO:0043486)3.80368225
71positive regulation of histone methylation (GO:0031062)3.79437638
72protein localization to chromosome (GO:0034502)3.78842570
73reciprocal meiotic recombination (GO:0007131)3.77271271
74reciprocal DNA recombination (GO:0035825)3.77271271
75chromatin remodeling at centromere (GO:0031055)3.76123254
76maturation of 5.8S rRNA (GO:0000460)3.75542547
77regulation of exit from mitosis (GO:0007096)3.75483080
78inner cell mass cell proliferation (GO:0001833)3.74996976
79nuclear pore complex assembly (GO:0051292)3.74803415
80CENP-A containing nucleosome assembly (GO:0034080)3.72209487
81sister chromatid segregation (GO:0000819)3.67087093
82regulation of sister chromatid cohesion (GO:0007063)3.66480459
83positive regulation of gastrulation (GO:2000543)3.63607622
84mitotic spindle checkpoint (GO:0071174)3.62653035
85regulation of double-strand break repair via homologous recombination (GO:0010569)3.62298761
86regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.58520589
87mitotic spindle assembly checkpoint (GO:0007094)3.55114492
88gene silencing (GO:0016458)3.54924402
89DNA replication-independent nucleosome assembly (GO:0006336)3.53274426
90DNA replication-independent nucleosome organization (GO:0034724)3.53274426
91regulation of chromosome segregation (GO:0051983)3.53086032
92spindle assembly checkpoint (GO:0071173)3.52153903
93negative regulation of meiotic cell cycle (GO:0051447)3.51920631
94cell-cell recognition (GO:0009988)3.51675279
95regulation of mitotic metaphase/anaphase transition (GO:0030071)3.51549304
96regulation of retinoic acid receptor signaling pathway (GO:0048385)3.50724289
97negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.49110578
98nuclear pore organization (GO:0006999)3.47187659
99negative regulation of nuclear division (GO:0051784)3.46182903
100DNA modification (GO:0006304)3.44754068
101positive regulation of mitotic sister chromatid separation (GO:1901970)3.44531723
102positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.44531723
103positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.44531723
104DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.43465295
105negative regulation of chromosome segregation (GO:0051985)3.41468139
106negative regulation of mitotic sister chromatid separation (GO:2000816)3.39741629
107negative regulation of mitotic sister chromatid segregation (GO:0033048)3.39741629
108negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.39741629
109negative regulation of sister chromatid segregation (GO:0033046)3.39741629
110regulation of chromatin silencing (GO:0031935)3.38234449
111mitotic nuclear envelope disassembly (GO:0007077)3.36160894
112positive regulation of chromosome segregation (GO:0051984)3.32910993
113regulation of histone methylation (GO:0031060)3.31547883
114positive regulation of reproductive process (GO:2000243)3.30313247
115regulation of calcium ion-dependent exocytosis (GO:0017158)3.30058392
116regulation of mitotic sister chromatid separation (GO:0010965)3.29857244
117regulation of mitotic sister chromatid segregation (GO:0033047)3.29857244
118regulation of sister chromatid segregation (GO:0033045)3.29857244
119negative regulation of cell division (GO:0051782)3.29601376
120regulation of histone H3-K4 methylation (GO:0051569)3.26320714
121negative regulation of gene silencing (GO:0060969)3.25931916
122DNA damage response, signal transduction resulting in transcription (GO:0042772)3.25538115
123resolution of meiotic recombination intermediates (GO:0000712)3.24033988
124glycine transport (GO:0015816)3.23880786
125regulation of hypersensitivity (GO:0002883)3.22493902
126histone H2A ubiquitination (GO:0033522)3.22311415
127mitotic sister chromatid cohesion (GO:0007064)3.22116383
128multicellular organism reproduction (GO:0032504)3.20844676
129nuclear envelope disassembly (GO:0051081)3.19361388
130membrane disassembly (GO:0030397)3.19361388
131regulation of spindle organization (GO:0090224)3.18380274
132germ cell development (GO:0007281)3.16968411
133centriole assembly (GO:0098534)3.15544609
134nuclear division (GO:0000280)3.11582672
135phosphorelay signal transduction system (GO:0000160)3.11016956
136regulation of reproductive process (GO:2000241)3.10561308
137regulation of phospholipid biosynthetic process (GO:0071071)3.08278822
138primitive streak formation (GO:0090009)3.05841562
139regulation of steroid hormone biosynthetic process (GO:0090030)3.02391062
140nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.01117749
141nucleus organization (GO:0006997)2.97580792
142regulation of chromatin binding (GO:0035561)2.96558568
143DNA replication-dependent nucleosome organization (GO:0034723)2.95778299
144DNA replication-dependent nucleosome assembly (GO:0006335)2.95778299
145phosphatidylinositol dephosphorylation (GO:0046856)2.90829926
146histone lysine demethylation (GO:0070076)2.88788737
147N-terminal protein amino acid acetylation (GO:0006474)2.87683285
148somite rostral/caudal axis specification (GO:0032525)2.86699233
149spermatid development (GO:0007286)2.82567335
150piRNA metabolic process (GO:0034587)12.5269238

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.24575454
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.20214572
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.30208440
4SALL1_21062744_ChIP-ChIP_HESCs_Human4.14804854
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.73645309
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.53372323
7AR_21909140_ChIP-Seq_LNCAP_Human3.21972697
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.07953954
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.83585012
10KAP1_22055183_ChIP-Seq_ESCs_Mouse2.69612555
11IGF1R_20145208_ChIP-Seq_DFB_Human2.64605726
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.55695312
13KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.55695312
14KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.55695312
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.44476736
16KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.40165655
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.36400762
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.17410457
19GATA1_26923725_Chip-Seq_HPCs_Mouse2.17057039
20* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.15712029
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.13966750
22RNF2_27304074_Chip-Seq_NSC_Mouse2.03110866
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.98248506
24FUS_26573619_Chip-Seq_HEK293_Human1.94993553
25TP63_19390658_ChIP-ChIP_HaCaT_Human1.90299780
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.87676644
27E2F1_21310950_ChIP-Seq_MCF-7_Human1.87383243
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76941820
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.73508081
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.68506325
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67455412
32EWS_26573619_Chip-Seq_HEK293_Human1.66802634
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.66258397
34GBX2_23144817_ChIP-Seq_PC3_Human1.62644502
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61714924
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60655366
37HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.59285091
38NFE2_27457419_Chip-Seq_LIVER_Mouse1.59046510
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.58628184
40PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.57134583
41STAT1_17558387_ChIP-Seq_HELA_Human1.56280619
42* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55236100
43TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.55192933
44CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.54280022
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.53465080
46STAT3_23295773_ChIP-Seq_U87_Human1.49279619
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.48548666
48RUNX1_26923725_Chip-Seq_HPCs_Mouse1.45663442
49RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44000043
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.43573861
51LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42144733
52RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39612793
53MYC_18940864_ChIP-ChIP_HL60_Human1.39463665
54TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.35821545
55CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32434110
56CDX2_22108803_ChIP-Seq_LS180_Human1.32179453
57EZH2_22144423_ChIP-Seq_EOC_Human1.31591839
58HTT_18923047_ChIP-ChIP_STHdh_Human1.31111983
59MYCN_18555785_ChIP-Seq_MESCs_Mouse1.30496636
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28685722
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28685722
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26658741
63CBP_20019798_ChIP-Seq_JUKART_Human1.23668415
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23668415
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20704874
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.20156908
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20112304
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19936459
69TP53_16413492_ChIP-PET_HCT116_Human1.17732920
70CREB1_15753290_ChIP-ChIP_HEK293T_Human1.17525960
71POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16611506
72AR_25329375_ChIP-Seq_VCAP_Human1.16378803
73STAT3_18555785_Chip-Seq_ESCs_Mouse1.15696080
74RUNX2_22187159_ChIP-Seq_PCA_Human1.15258290
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14682123
76CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.14479334
77TBL1_22424771_ChIP-Seq_293T_Human1.14262778
78EP300_21415370_ChIP-Seq_HL-1_Mouse1.12603742
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11965265
80SMAD4_21741376_ChIP-Seq_EPCs_Human1.10473272
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09935279
82ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08590937
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08496245
84OCT4_18555785_Chip-Seq_ESCs_Mouse1.08190500
85CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08107924
86TCF4_23295773_ChIP-Seq_U87_Human1.07658693
87AUTS2_25519132_ChIP-Seq_293T-REX_Human1.07508964
88GATA3_21867929_ChIP-Seq_TH1_Mouse1.06294024
89BCAT_22108803_ChIP-Seq_LS180_Human1.05943013
90FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05713579
91NMYC_18555785_Chip-Seq_ESCs_Mouse1.05465389
92KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04192207
93ELK4_26923725_Chip-Seq_MESODERM_Mouse1.04084235
94RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03820025
95SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03795093
96ESRRB_18555785_Chip-Seq_ESCs_Mouse1.03389292
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03067886
98TAL1_26923725_Chip-Seq_HPCs_Mouse1.02250637
99KLF4_18555785_Chip-Seq_ESCs_Mouse1.02243543
100SOX2_18555785_Chip-Seq_ESCs_Mouse1.02167924
101FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.01360380
102NFYA_21822215_ChIP-Seq_K562_Human1.01203526
103PKCTHETA_26484144_Chip-Seq_BREAST_Human1.01096280
104E2F1_18555785_Chip-Seq_ESCs_Mouse1.00782244
105KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.00425676
106ZNF274_21170338_ChIP-Seq_K562_Hela1.00416072
107PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00226801
108CTCF_18555785_Chip-Seq_ESCs_Mouse1.00035951
109CRX_20693478_ChIP-Seq_RETINA_Mouse0.99529522
110PRDM14_20953172_ChIP-Seq_ESCs_Human0.98972982
111SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98823619
112EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98290542
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98216477
114HNFA_21074721_ChIP-Seq_CACO-2_Human0.98207163
115SMAD4_21799915_ChIP-Seq_A2780_Human0.97940921
116MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97750026
117SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.97691593
118ZFX_18555785_Chip-Seq_ESCs_Mouse0.95316902
119OCT4_21477851_ChIP-Seq_ESCs_Mouse0.95178068
120CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93570342
121PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92277439
122ETV1_20927104_ChIP-Seq_GIST48_Human0.91929211
123TCF4_18268006_ChIP-ChIP_LS174T_Human0.91072706
124PHF8_20622853_ChIP-Seq_HELA_Human0.91043269
125SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88875208
126CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88260572
127GF1_26923725_Chip-Seq_HPCs_Mouse0.87686437
128SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87404580
129PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87194430
130NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.84998859
131CBP_21632823_ChIP-Seq_H3396_Human0.84244664
132LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83405742
133FOXH1_21741376_ChIP-Seq_EPCs_Human0.81484077
134YY1_21170310_ChIP-Seq_MESCs_Mouse0.80936174
135P300_19829295_ChIP-Seq_ESCs_Human0.80420023
136SMAD3_21741376_ChIP-Seq_EPCs_Human0.79115122
137SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79078997
138TAF15_26573619_Chip-Seq_HEK293_Human0.78844832
139TP53_22573176_ChIP-Seq_HFKS_Human0.74740692
140CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.73233721
141FOXP3_21729870_ChIP-Seq_TREG_Human0.72246213
142NANOG_20526341_ChIP-Seq_ESCs_Human0.71192111
143GATA3_26560356_Chip-Seq_TH1_Human0.70860147
144E2F1_17053090_ChIP-ChIP_MCF-7_Human0.70549418
145KLF4_19829295_ChIP-Seq_ESCs_Human0.70171975
146FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.69342753
147FOXA1_27270436_Chip-Seq_PROSTATE_Human0.67304391
148FOXA1_25329375_ChIP-Seq_VCAP_Human0.67304391
149FOXA1_21572438_ChIP-Seq_LNCaP_Human0.67195101
150THAP11_20581084_ChIP-Seq_MESCs_Mouse0.66748359

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation8.20372520
2MP0003718_maternal_effect4.93130038
3MP0002102_abnormal_ear_morphology4.69098445
4MP0005451_abnormal_body_composition3.96467018
5MP0008789_abnormal_olfactory_epithelium3.82887552
6MP0003693_abnormal_embryo_hatching3.68909793
7MP0010094_abnormal_chromosome_stability3.59871803
8MP0008995_early_reproductive_senescence3.44909048
9MP0002210_abnormal_sex_determination3.29713831
10MP0005394_taste/olfaction_phenotype3.23363238
11MP0005499_abnormal_olfactory_system3.23363238
12MP0001929_abnormal_gametogenesis3.22092894
13MP0003787_abnormal_imprinting3.17089858
14MP0003111_abnormal_nucleus_morphology2.90842441
15MP0000653_abnormal_sex_gland2.75743446
16MP0003077_abnormal_cell_cycle2.74598783
17MP0003646_muscle_fatigue2.59326714
18MP0002139_abnormal_hepatobiliary_system2.58560711
19MP0001145_abnormal_male_reproductive2.51791160
20MP0008058_abnormal_DNA_repair2.43591134
21MP0003121_genomic_imprinting2.38615090
22MP0010030_abnormal_orbit_morphology2.32557732
23MP0001119_abnormal_female_reproductive2.31608803
24MP0003183_abnormal_peptide_metabolism2.28557126
25MP0008057_abnormal_DNA_replication2.27871001
26MP0004957_abnormal_blastocyst_morpholog2.18986874
27MP0003699_abnormal_female_reproductive2.18428299
28MP0003123_paternal_imprinting2.14366526
29MP0005395_other_phenotype2.13944142
30MP0003698_abnormal_male_reproductive2.03895312
31MP0003786_premature_aging1.99144189
32MP0002234_abnormal_pharynx_morphology1.80723615
33MP0008007_abnormal_cellular_replicative1.80221598
34MP0002161_abnormal_fertility/fecundity1.72487273
35MP0009840_abnormal_foam_cell1.69700963
36MP0002138_abnormal_hepatobiliary_system1.67994651
37MP0002653_abnormal_ependyma_morphology1.66535712
38MP0003879_abnormal_hair_cell1.62958796
39MP0008932_abnormal_embryonic_tissue1.57781998
40MP0000566_synostosis1.46599499
41MP0000462_abnormal_digestive_system1.45280178
42MP0010368_abnormal_lymphatic_system1.45268127
43MP0005408_hypopigmentation1.44450064
44MP0001730_embryonic_growth_arrest1.39072420
45MP0003937_abnormal_limbs/digits/tail_de1.33182952
46MP0005380_embryogenesis_phenotype1.28839108
47MP0001672_abnormal_embryogenesis/_devel1.28839108
48MP0001984_abnormal_olfaction1.28246191
49MP0000579_abnormal_nail_morphology1.27491119
50MP0004264_abnormal_extraembryonic_tissu1.23945277
51MP0005360_urolithiasis1.22711206
52MP0006292_abnormal_olfactory_placode1.21937601
53MP0010307_abnormal_tumor_latency1.21536305
54MP0000350_abnormal_cell_proliferation1.20895933
55MP0002085_abnormal_embryonic_tissue1.20162629
56MP0000569_abnormal_digit_pigmentation1.18972384
57MP0005647_abnormal_sex_gland1.15067407
58MP0002084_abnormal_developmental_patter1.12074875
59MP0000678_abnormal_parathyroid_gland1.09930491
60MP0001293_anophthalmia1.09553186
61MP0002233_abnormal_nose_morphology1.08405235
62MP0001697_abnormal_embryo_size1.08198022
63MP0003315_abnormal_perineum_morphology1.07159997
64MP0003890_abnormal_embryonic-extraembry1.04528146
65MP0005410_abnormal_fertilization1.01115397
66MP0000631_abnormal_neuroendocrine_gland0.99841965
67MP0000762_abnormal_tongue_morphology0.97565857
68MP0003950_abnormal_plasma_membrane0.97124571
69MP0009697_abnormal_copulation0.94070064
70MP0003984_embryonic_growth_retardation0.93978129
71MP0001666_abnormal_nutrient_absorption0.88872000
72MP0005310_abnormal_salivary_gland0.87036043
73MP0002088_abnormal_embryonic_growth/wei0.86489744
74MP0005389_reproductive_system_phenotype0.83094323
75MP0002249_abnormal_larynx_morphology0.81409984
76MP0003878_abnormal_ear_physiology0.78796096
77MP0005377_hearing/vestibular/ear_phenot0.78796096
78MP0001919_abnormal_reproductive_system0.78381536
79MP0002019_abnormal_tumor_incidence0.76188049
80MP0000427_abnormal_hair_cycle0.76053538
81MP0003252_abnormal_bile_duct0.74696640
82MP0002272_abnormal_nervous_system0.74676860
83MP0002638_abnormal_pupillary_reflex0.72148801
84MP0001664_abnormal_digestion0.71265984
85MP0001986_abnormal_taste_sensitivity0.70943967
86MP0003119_abnormal_digestive_system0.70096307
87MP0004185_abnormal_adipocyte_glucose0.69436966
88MP0000313_abnormal_cell_death0.68509529
89MP0002086_abnormal_extraembryonic_tissu0.68295917
90MP0003755_abnormal_palate_morphology0.67931455
91MP0003936_abnormal_reproductive_system0.67356007
92MP0000639_abnormal_adrenal_gland0.66290301
93MP0003935_abnormal_craniofacial_develop0.64534877
94MP0005621_abnormal_cell_physiology0.64302275
95MP0002160_abnormal_reproductive_system0.64267887
96MP0001324_abnormal_eye_pigmentation0.63923333
97MP0001915_intracranial_hemorrhage0.63830132
98MP0002396_abnormal_hematopoietic_system0.63341063
99MP0005085_abnormal_gallbladder_physiolo0.63330819
100MP0004142_abnormal_muscle_tone0.62245470
101MP0000647_abnormal_sebaceous_gland0.61027965
102MP0005551_abnormal_eye_electrophysiolog0.60785389
103MP0000015_abnormal_ear_pigmentation0.60219397
104MP0000377_abnormal_hair_follicle0.59455583
105MP0002928_abnormal_bile_duct0.59453690
106MP0000490_abnormal_crypts_of0.59328545
107MP0003221_abnormal_cardiomyocyte_apopto0.58245891
108MP0003941_abnormal_skin_development0.57356374
109MP0000432_abnormal_head_morphology0.57122215
110MP0002080_prenatal_lethality0.55960040
111MP0010234_abnormal_vibrissa_follicle0.55088700
112MP0003763_abnormal_thymus_physiology0.54084291
113MP0000049_abnormal_middle_ear0.53381465
114MP0010678_abnormal_skin_adnexa0.53315197
115MP0000383_abnormal_hair_follicle0.52670246
116MP0001502_abnormal_circadian_rhythm0.52648192
117MP0004808_abnormal_hematopoietic_stem0.51987521
118MP0003861_abnormal_nervous_system0.51962113
119MP0005384_cellular_phenotype0.51076585
120MP0009672_abnormal_birth_weight0.51017829
121MP0005409_darkened_coat_color0.50444799
122MP0001346_abnormal_lacrimal_gland0.50433687
123MP0008260_abnormal_autophagy0.49903984
124MP0004233_abnormal_muscle_weight0.49526544
125MP0003959_abnormal_lean_body0.49023774
126MP0004145_abnormal_muscle_electrophysio0.48625364
127MP0003868_abnormal_feces_composition0.48540392
128MP0006276_abnormal_autonomic_nervous0.47162986
129MP0005174_abnormal_tail_pigmentation0.47160854
130MP0004084_abnormal_cardiac_muscle0.47034829
131MP0001963_abnormal_hearing_physiology0.46552916
132MP0002877_abnormal_melanocyte_morpholog0.46462274
133MP0004381_abnormal_hair_follicle0.45927528
134MP0000733_abnormal_muscle_development0.45735770
135MP0001545_abnormal_hematopoietic_system0.45709805
136MP0005397_hematopoietic_system_phenotyp0.45709805
137MP0005646_abnormal_pituitary_gland0.42954257
138MP0002089_abnormal_postnatal_growth/wei0.42601061
139MP0002177_abnormal_outer_ear0.42512109
140MP0004036_abnormal_muscle_relaxation0.42403427
141MP0001216_abnormal_epidermal_layer0.40980861
142MP0002060_abnormal_skin_morphology0.40802131
143MP0005076_abnormal_cell_differentiation0.40564586
144MP0000026_abnormal_inner_ear0.38937748
145MP0005501_abnormal_skin_physiology0.38381499

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)6.93712614
2Chromosomal breakage induced by crosslinking agents (HP:0003221)6.23173992
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.72265767
4Male infertility (HP:0003251)5.69094923
5Papillary thyroid carcinoma (HP:0002895)5.34137323
6Azoospermia (HP:0000027)5.19289822
7Osteomalacia (HP:0002749)4.95489816
8Cortical dysplasia (HP:0002539)4.90088766
9Anterior segment dysgenesis (HP:0007700)4.78730223
10Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.62600240
11Hypoplasia of the fovea (HP:0007750)4.54852794
12Aplasia/Hypoplasia of the fovea (HP:0008060)4.54852794
13Abnormal spermatogenesis (HP:0008669)4.53456594
14Abdominal situs inversus (HP:0003363)4.50762147
15Abnormality of abdominal situs (HP:0011620)4.50762147
16Abnormality of the fovea (HP:0000493)4.03537187
17Abnormality of chromosome stability (HP:0003220)3.99558301
18Facial hemangioma (HP:0000329)3.94778612
19Gonadotropin excess (HP:0000837)3.84278226
20Impulsivity (HP:0100710)3.66102056
21Abnormal respiratory motile cilium physiology (HP:0012261)3.63027524
22Abnormality of the fingertips (HP:0001211)3.58060337
23Premature ovarian failure (HP:0008209)3.57487955
24Cholecystitis (HP:0001082)3.56935707
25Abnormal gallbladder physiology (HP:0012438)3.56935707
26Hypophosphatemic rickets (HP:0004912)3.42507136
27Shawl scrotum (HP:0000049)3.37971822
28Secondary amenorrhea (HP:0000869)3.27940697
29Infertility (HP:0000789)3.25929226
30Abnormality of the labia minora (HP:0012880)3.25526000
31Ectopic kidney (HP:0000086)3.20651646
32Chronic bronchitis (HP:0004469)3.19928345
33Lip pit (HP:0100267)3.18502695
34Breast hypoplasia (HP:0003187)3.10787243
35Capillary hemangiomas (HP:0005306)3.10690484
36Aplasia/Hypoplasia of the uvula (HP:0010293)3.09533647
37Oligodactyly (hands) (HP:0001180)3.08259616
38Abnormality of chromosome segregation (HP:0002916)3.07315212
39Meckel diverticulum (HP:0002245)3.06984057
40Abnormality of the preputium (HP:0100587)3.05459595
41Acute myeloid leukemia (HP:0004808)3.03791480
42Patellar aplasia (HP:0006443)2.99832775
43Prostate neoplasm (HP:0100787)2.97017890
44Median cleft lip (HP:0000161)2.92794768
45Apathy (HP:0000741)2.91036918
46Septo-optic dysplasia (HP:0100842)2.89595251
47Adrenal hypoplasia (HP:0000835)2.87139727
48Abnormality of the ileum (HP:0001549)2.85357416
49Birth length less than 3rd percentile (HP:0003561)2.82405592
50Thyroid carcinoma (HP:0002890)2.78137128
51Aplasia/Hypoplasia of the macula (HP:0008059)2.77335285
52Diminished motivation (HP:0000745)2.76916427
53Aplasia/Hypoplasia of the patella (HP:0006498)2.74672042
54Oligodactyly (HP:0012165)2.72556634
55Hypokinesia (HP:0002375)2.71013845
56Aplasia/Hypoplasia of the earlobes (HP:0009906)2.66337310
57Short tibia (HP:0005736)2.65361738
58Abnormal lung lobation (HP:0002101)2.65210241
59Sandal gap (HP:0001852)2.61629667
60Absent septum pellucidum (HP:0001331)2.59919234
61Proximal tubulopathy (HP:0000114)2.55501915
62Tubulointerstitial nephritis (HP:0001970)2.55402468
63Aplasia/Hypoplasia affecting the retina (HP:0008061)2.52654160
64Short thumb (HP:0009778)2.50842439
65Rhinitis (HP:0012384)2.49851708
66Supernumerary spleens (HP:0009799)2.49250170
67Small intestinal stenosis (HP:0012848)2.47258281
68Duodenal stenosis (HP:0100867)2.47258281
69Hypergonadotropic hypogonadism (HP:0000815)2.45535493
70Flat capital femoral epiphysis (HP:0003370)2.44596745
71Abnormality of the carotid arteries (HP:0005344)2.44341356
72Loss of speech (HP:0002371)2.43692548
73Fair hair (HP:0002286)2.39610411
74Abnormal ciliary motility (HP:0012262)2.39405633
75Metaphyseal irregularity (HP:0003025)2.37505976
76Primary amenorrhea (HP:0000786)2.36821056
77Clubbing of toes (HP:0100760)2.33901771
78Enlarged penis (HP:0000040)2.33454368
79Aplasia/Hypoplasia of the tibia (HP:0005772)2.33180409
80Volvulus (HP:0002580)2.32811667
81Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.30682617
82Bundle branch block (HP:0011710)2.30033069
83Increased nuchal translucency (HP:0010880)2.27556369
84Lower limb hyperreflexia (HP:0002395)2.26983200
85Insulin-resistant diabetes mellitus (HP:0000831)2.26178755
86Sloping forehead (HP:0000340)2.24765319
87Spontaneous abortion (HP:0005268)2.21904436
88Horizontal nystagmus (HP:0000666)2.19295680
89Abnormality of the septum pellucidum (HP:0007375)2.18068220
90Carpal bone hypoplasia (HP:0001498)2.17832433
91Nephroblastoma (Wilms tumor) (HP:0002667)2.16812873
92Urethral obstruction (HP:0000796)2.16608734
93Pulmonary fibrosis (HP:0002206)2.15102685
94Absent radius (HP:0003974)2.12604595
95Heterotopia (HP:0002282)2.12410543
96Microglossia (HP:0000171)2.09818555
97Hypoplastic iliac wings (HP:0002866)2.08739929
98Aplasia/Hypoplasia of the breasts (HP:0010311)2.05092973
99Neoplasm of the oral cavity (HP:0100649)2.01361664
100Aplasia involving forearm bones (HP:0009822)1.99976381
101Absent forearm bone (HP:0003953)1.99976381
102Breast aplasia (HP:0100783)1.99854352
103Abnormality of the labia (HP:0000058)1.98225515
104Abnormality of male internal genitalia (HP:0000022)1.98089774
105Embryonal renal neoplasm (HP:0011794)1.96867212
106Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.96446314
107Dysdiadochokinesis (HP:0002075)1.95050975
108Non-midline cleft lip (HP:0100335)1.93451098
109Abnormality of the anterior chamber (HP:0000593)1.93292957
110Malnutrition (HP:0004395)1.92469143
111Sparse lateral eyebrow (HP:0005338)1.91058211
112Abnormality of the phalanges of the hallux (HP:0010057)1.89882339
113Aplasia/Hypoplasia involving the musculature (HP:0001460)1.89799686
114Aplasia of the musculature (HP:0100854)1.88117809
115Myelodysplasia (HP:0002863)1.87539937
116Aplasia/Hypoplasia of the sternum (HP:0006714)1.84051377
117Nephronophthisis (HP:0000090)1.83318058
118Disinhibition (HP:0000734)1.80522732
119Aplasia/Hypoplasia of the tongue (HP:0010295)1.80092652
120Abnormality of the duodenum (HP:0002246)1.79567920
121Abnormality of DNA repair (HP:0003254)1.79227941
122Abnormality of the epiphysis of the femoral head (HP:0010574)1.79175083
123Skin pits (HP:0100276)1.78490767
124Hyperglycemia (HP:0003074)1.77608453
125Abnormal auditory evoked potentials (HP:0006958)1.77030125
126Dynein arm defect of respiratory motile cilia (HP:0012255)1.76444875
127Absent/shortened dynein arms (HP:0200106)1.76444875
128Wrist flexion contracture (HP:0001239)1.76294786
129Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.75265251
130Medulloblastoma (HP:0002885)1.75227056
131Type 2 muscle fiber atrophy (HP:0003554)1.74915208
132Myokymia (HP:0002411)1.74592123
133Stillbirth (HP:0003826)1.74392871
134Prominent nose (HP:0000448)1.74381046
135Cone-rod dystrophy (HP:0000548)1.74356798
136Ankle contracture (HP:0006466)1.73431143
137Generalized aminoaciduria (HP:0002909)1.72453891
138Rickets (HP:0002748)1.71992209
139Leiomyosarcoma (HP:0100243)1.71625470
140Uterine leiomyosarcoma (HP:0002891)1.71625470
141Anhidrosis (HP:0000970)1.71489867
142Hydroureter (HP:0000072)1.71004759
143Bicornuate uterus (HP:0000813)1.70761455
144Truncal obesity (HP:0001956)1.70062847
145Intrahepatic cholestasis (HP:0001406)1.67266965
146Bronchiectasis (HP:0002110)1.65779748
147Rhabdomyosarcoma (HP:0002859)1.64968952
148Spinal cord compression (HP:0002176)1.64636793
149Maternal diabetes (HP:0009800)1.64397511
150Abnormal biliary tract physiology (HP:0012439)1.64121768
151Cafe-au-lait spot (HP:0000957)1.62825573
152Abnormality of the proximal phalanges of the hand (HP:0009834)1.62811976
153Abnormality of the renal medulla (HP:0100957)1.62334532
154Horseshoe kidney (HP:0000085)1.59613313
155Abnormality of lateral ventricle (HP:0030047)1.59526219
156Abnormality of femoral epiphyses (HP:0006499)1.59350857
157Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.59350857
158Abnormality of the femoral head (HP:0003368)1.59019785
159Male pseudohermaphroditism (HP:0000037)1.54914233
160Overlapping toe (HP:0001845)1.50962733

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.16448887
2MAP3K63.86706017
3PLK43.81245513
4CDC73.59005033
5EIF2AK13.51246619
6TAOK33.44340144
7MET3.39062477
8LATS23.19951612
9MAP3K93.16656139
10TTK3.10047719
11NEK62.93523720
12STK38L2.86425717
13CDK122.84039964
14PNCK2.43275100
15BRAF2.42296586
16MUSK2.34270978
17ACVR1B2.30421392
18PRKD32.29824448
19NEK22.28099108
20STK32.18648207
21ERBB42.17589925
22CDK192.07054394
23CHEK22.05389391
24TAOK12.02544032
25MAP3K41.81434642
26EEF2K1.69971870
27NEK91.69135270
28KSR21.67185696
29PRKCI1.58217726
30CDK91.56211799
31PLK11.56057951
32TRIM281.52656359
33MELK1.37739334
34PDK31.36644242
35PDK41.36644242
36CAMK1G1.30806467
37RAF11.22654282
38STK101.20979906
39NTRK31.20478185
40MAP3K131.19888910
41MAP2K71.16948951
42BRSK11.16605827
43MOS1.12278778
44PTK21.11891139
45TYRO31.10234065
46CHEK11.08911928
47TNIK1.07624047
48EIF2AK31.06102628
49WNK11.04793048
50CDK81.02724487
51ZAK1.01284563
52MAPKAPK30.98232749
53ATM0.97628064
54ARAF0.95270948
55AURKB0.94478859
56STK390.89366312
57MAP3K80.87081103
58CAMK1D0.85353000
59ATR0.84952545
60BUB10.84732064
61STK380.80749722
62PRKD20.80036892
63MAPK130.79346947
64MST40.77128337
65PBK0.76470401
66KSR10.76151728
67NUAK10.73448675
68EPHA40.72738288
69CDK30.69605092
70CSNK1G10.69060278
71PINK10.68938297
72PRKAA10.68868720
73MAP2K40.64542394
74WNK30.62317046
75CDK70.61397039
76PAK60.60435656
77PDK20.57406789
78CDK10.55784639
79OXSR10.55111264
80CDK20.54241631
81PLK30.54061705
82BMPR1B0.52898167
83VRK10.52574000
84STK240.52214845
85PRKAA20.52212009
86CDK40.52128112
87AURKA0.51803216
88BMPR20.51188719
89TGFBR10.50313096
90MAP3K50.50305269
91CSNK1G20.49426795
92DMPK0.49325312
93STK40.46929845
94PRKG10.46467282
95NTRK20.45794625
96RET0.44645330
97CSNK1A1L0.44339208
98BRSK20.42637899
99PIM10.42172799
100TEC0.40536964
101MTOR0.40519099
102WEE10.39669957
103ABL10.39652763
104MARK30.38807622
105MAPK100.38599457
106ABL20.38293545
107PRKCZ0.37846752
108TAOK20.37723643
109PLK20.37353914
110DYRK20.36604445
111CHUK0.36379284
112RPS6KB20.35914564
113TSSK60.35627018
114CDK50.34197344
115PRKACB0.33968294
116STK110.33777207
117CSNK1G30.33760887
118CSNK1E0.32943571
119EGFR0.32513985
120TLK10.32031213
121NME10.31040207
122SGK20.30428518
123CSNK1D0.29327447
124MAPK140.28655597
125BRD40.28563131
126AKT10.28385372
127GSK3B0.28336392
128JAK30.28141603
129AKT20.26380105
130MAPK10.26003091
131PAK10.25932873
132FLT30.25728547
133IRAK20.25720341
134TRPM70.25317202
135NLK0.25101895
136SRPK10.24785075
137CDK11A0.24257955
138RPS6KA40.23551506
139CAMK2A0.23102530
140NEK10.22783631

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030224.41766191
2* Cell cycle_Homo sapiens_hsa041103.76052219
3Homologous recombination_Homo sapiens_hsa034403.35088277
4Fanconi anemia pathway_Homo sapiens_hsa034603.22864521
5Dorso-ventral axis formation_Homo sapiens_hsa043203.15616918
6RNA degradation_Homo sapiens_hsa030183.15513629
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.10152595
8RNA transport_Homo sapiens_hsa030132.73785555
9Non-homologous end-joining_Homo sapiens_hsa034502.62679129
10Vitamin B6 metabolism_Homo sapiens_hsa007502.61395806
11Ovarian steroidogenesis_Homo sapiens_hsa049132.59901167
12Linoleic acid metabolism_Homo sapiens_hsa005912.49425272
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.42678391
14Oocyte meiosis_Homo sapiens_hsa041142.27253914
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.14706059
16Caffeine metabolism_Homo sapiens_hsa002321.98482197
17Circadian rhythm_Homo sapiens_hsa047101.97642530
18Ether lipid metabolism_Homo sapiens_hsa005651.96598598
19* p53 signaling pathway_Homo sapiens_hsa041151.87461353
20RNA polymerase_Homo sapiens_hsa030201.86610740
21* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.77830328
22TGF-beta signaling pathway_Homo sapiens_hsa043501.74002461
23Base excision repair_Homo sapiens_hsa034101.72635421
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.64219058
25Pancreatic cancer_Homo sapiens_hsa052121.63107967
26Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.59219682
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.58886269
28Gap junction_Homo sapiens_hsa045401.54416451
29mRNA surveillance pathway_Homo sapiens_hsa030151.50253511
30MicroRNAs in cancer_Homo sapiens_hsa052061.35830037
31DNA replication_Homo sapiens_hsa030301.35808808
32Herpes simplex infection_Homo sapiens_hsa051681.31256245
33Glycerophospholipid metabolism_Homo sapiens_hsa005641.28907719
34Olfactory transduction_Homo sapiens_hsa047401.27159278
35Nucleotide excision repair_Homo sapiens_hsa034201.24320939
36Mismatch repair_Homo sapiens_hsa034301.24281725
37Nicotine addiction_Homo sapiens_hsa050331.19527692
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.10018058
39Prolactin signaling pathway_Homo sapiens_hsa049171.08506491
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.07580867
41Lysine degradation_Homo sapiens_hsa003101.02656268
42Choline metabolism in cancer_Homo sapiens_hsa052311.00257387
43ABC transporters_Homo sapiens_hsa020100.99884399
44Adherens junction_Homo sapiens_hsa045200.99624559
45Colorectal cancer_Homo sapiens_hsa052100.94973519
46GnRH signaling pathway_Homo sapiens_hsa049120.93196365
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86867838
48Small cell lung cancer_Homo sapiens_hsa052220.83119002
49Hippo signaling pathway_Homo sapiens_hsa043900.82509998
50Purine metabolism_Homo sapiens_hsa002300.74836679
51Vitamin digestion and absorption_Homo sapiens_hsa049770.74170976
52Thyroid cancer_Homo sapiens_hsa052160.72151929
53Epstein-Barr virus infection_Homo sapiens_hsa051690.71317243
54Synaptic vesicle cycle_Homo sapiens_hsa047210.71158446
55HTLV-I infection_Homo sapiens_hsa051660.69494259
56GABAergic synapse_Homo sapiens_hsa047270.69484598
57NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67557515
58VEGF signaling pathway_Homo sapiens_hsa043700.66896315
59Phototransduction_Homo sapiens_hsa047440.65466371
60Taste transduction_Homo sapiens_hsa047420.65465921
61Renal cell carcinoma_Homo sapiens_hsa052110.64807191
62Sulfur relay system_Homo sapiens_hsa041220.64650399
63Arachidonic acid metabolism_Homo sapiens_hsa005900.62987407
64Pyrimidine metabolism_Homo sapiens_hsa002400.62310567
65Huntingtons disease_Homo sapiens_hsa050160.61124650
66Ras signaling pathway_Homo sapiens_hsa040140.56983748
67Influenza A_Homo sapiens_hsa051640.56695594
68Glycerolipid metabolism_Homo sapiens_hsa005610.54957721
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54756843
70* FoxO signaling pathway_Homo sapiens_hsa040680.53645827
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53582958
72Morphine addiction_Homo sapiens_hsa050320.52682823
73Bile secretion_Homo sapiens_hsa049760.52358701
74mTOR signaling pathway_Homo sapiens_hsa041500.51977255
75Propanoate metabolism_Homo sapiens_hsa006400.51242910
76Fatty acid elongation_Homo sapiens_hsa000620.51006848
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50336056
78Endometrial cancer_Homo sapiens_hsa052130.49820655
79Notch signaling pathway_Homo sapiens_hsa043300.45052023
80Inositol phosphate metabolism_Homo sapiens_hsa005620.44346011
81Long-term depression_Homo sapiens_hsa047300.44263840
82Spliceosome_Homo sapiens_hsa030400.43610314
83One carbon pool by folate_Homo sapiens_hsa006700.42228198
84Prostate cancer_Homo sapiens_hsa052150.42098223
85TNF signaling pathway_Homo sapiens_hsa046680.41594225
86Steroid biosynthesis_Homo sapiens_hsa001000.40941343
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40174288
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.39907862
89Tight junction_Homo sapiens_hsa045300.39097847
90Folate biosynthesis_Homo sapiens_hsa007900.38834995
91cAMP signaling pathway_Homo sapiens_hsa040240.37794601
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35804619
93Viral carcinogenesis_Homo sapiens_hsa052030.35804276
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.35726328
95Hepatitis B_Homo sapiens_hsa051610.34771149
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34592536
97Pathways in cancer_Homo sapiens_hsa052000.34567106
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33680386
99Hedgehog signaling pathway_Homo sapiens_hsa043400.32060570
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30691353
101Non-small cell lung cancer_Homo sapiens_hsa052230.29908992
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28871573
103Regulation of autophagy_Homo sapiens_hsa041400.28846597
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.28145139
105Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.28120789
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.27866068
107Estrogen signaling pathway_Homo sapiens_hsa049150.27757533
108ErbB signaling pathway_Homo sapiens_hsa040120.27476005
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.27472449
110Jak-STAT signaling pathway_Homo sapiens_hsa046300.27040935
111Histidine metabolism_Homo sapiens_hsa003400.26810781
112Wnt signaling pathway_Homo sapiens_hsa043100.26141224
113Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.24784867
114Serotonergic synapse_Homo sapiens_hsa047260.24081638
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.22791397
116Arginine and proline metabolism_Homo sapiens_hsa003300.22674766
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.22269664
118MAPK signaling pathway_Homo sapiens_hsa040100.21270973
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.20905149
120Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.20849845
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.20702736
122Aldosterone synthesis and secretion_Homo sapiens_hsa049250.19048755
123Insulin signaling pathway_Homo sapiens_hsa049100.18509774
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.18263162
125Toxoplasmosis_Homo sapiens_hsa051450.18064956
126Pyruvate metabolism_Homo sapiens_hsa006200.17999588
127Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.17543022
128Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.16093328
129beta-Alanine metabolism_Homo sapiens_hsa004100.15444477
130Shigellosis_Homo sapiens_hsa051310.15357627
131Phagosome_Homo sapiens_hsa041450.15038666
132Glucagon signaling pathway_Homo sapiens_hsa049220.14956836
133Sphingolipid metabolism_Homo sapiens_hsa006000.14745364
134Chronic myeloid leukemia_Homo sapiens_hsa052200.14288697
135Regulation of actin cytoskeleton_Homo sapiens_hsa048100.13208434
136Biosynthesis of amino acids_Homo sapiens_hsa012300.12612154
137Dopaminergic synapse_Homo sapiens_hsa047280.12593397
138Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.12432104
139Endocytosis_Homo sapiens_hsa041440.07593086
140Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.06874761
141Metabolic pathways_Homo sapiens_hsa011000.06831333
142Drug metabolism - other enzymes_Homo sapiens_hsa009830.06386117

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