ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.98916563
2	L-fucose catabolic process (GO:0042355)	4.24985612
3	fucose catabolic process (GO:0019317)	4.24985612
4	L-fucose metabolic process (GO:0042354)	4.24985612
5	response to pheromone (GO:0019236)	3.62265520
6	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.60243747
7	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.60243747
8	NADH dehydrogenase complex assembly (GO:0010257)	3.60243747
9	protein complex biogenesis (GO:0070271)	3.52629725
10	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.50889065
11	pyrimidine nucleobase catabolic process (GO:0006208)	3.50540227
12	water-soluble vitamin biosynthetic process (GO:0042364)	3.40922250
13	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.36972051
14	cellular ketone body metabolic process (GO:0046950)	3.31461192
15	kynurenine metabolic process (GO:0070189)	3.30655241
16	negative regulation of telomere maintenance (GO:0032205)	3.28130439
17	tryptophan catabolic process (GO:0006569)	3.26018012
18	indole-containing compound catabolic process (GO:0042436)	3.26018012
19	indolalkylamine catabolic process (GO:0046218)	3.26018012
20	mitochondrial respiratory chain complex assembly (GO:0033108)	3.23090784
21	epithelial cilium movement (GO:0003351)	3.16724069
22	protein polyglutamylation (GO:0018095)	3.09944077
23	respiratory chain complex IV assembly (GO:0008535)	3.09020039
24	platelet dense granule organization (GO:0060155)	3.08571492
25	nucleobase catabolic process (GO:0046113)	3.06191661
26	ATP synthesis coupled proton transport (GO:0015986)	3.05536726
27	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.05536726
28	indolalkylamine metabolic process (GO:0006586)	3.04902526
29	kidney morphogenesis (GO:0060993)	3.04444967
30	ketone body metabolic process (GO:1902224)	3.03220879
31	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.03124501
32	DNA deamination (GO:0045006)	3.02331522
33	nonmotile primary cilium assembly (GO:0035058)	3.00770418
34	nephron epithelium morphogenesis (GO:0072088)	2.97393618
35	nephron tubule morphogenesis (GO:0072078)	2.97393618
36	serotonin metabolic process (GO:0042428)	2.96593444
37	primary amino compound metabolic process (GO:1901160)	2.96015132
38	gamma-aminobutyric acid transport (GO:0015812)	2.95005588
39	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.94356100
40	behavioral response to ethanol (GO:0048149)	2.92831808
41	ubiquinone biosynthetic process (GO:0006744)	2.92589265
42	sulfation (GO:0051923)	2.91531440
43	neuronal action potential (GO:0019228)	2.88634532
44	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.88627676
45	piRNA metabolic process (GO:0034587)	2.87894578
46	protein-cofactor linkage (GO:0018065)	2.87302358
47	somite development (GO:0061053)	2.86692824
48	regulation of action potential (GO:0098900)	2.85427995
49	ubiquinone metabolic process (GO:0006743)	2.83542034
50	detection of light stimulus involved in sensory perception (GO:0050962)	2.81797883
51	detection of light stimulus involved in visual perception (GO:0050908)	2.81797883
52	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.78593527
53	indole-containing compound metabolic process (GO:0042430)	2.78275286
54	synaptic transmission, cholinergic (GO:0007271)	2.77842386
55	protein localization to cilium (GO:0061512)	2.77554202
56	axoneme assembly (GO:0035082)	2.75311159
57	tryptophan metabolic process (GO:0006568)	2.72916523
58	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.72439846
59	regulation of cilium movement (GO:0003352)	2.70462552
60	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.70365365
61	transmission of nerve impulse (GO:0019226)	2.68753606
62	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.67299941
63	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.67236411
64	presynaptic membrane assembly (GO:0097105)	2.66354523
65	rRNA catabolic process (GO:0016075)	2.63943938
66	cilium morphogenesis (GO:0060271)	2.63190592
67	cytochrome complex assembly (GO:0017004)	2.61573031
68	cornea development in camera-type eye (GO:0061303)	2.61539070
69	cell proliferation in forebrain (GO:0021846)	2.61100046
70	cilium movement (GO:0003341)	2.58085712
71	negative regulation of mast cell activation (GO:0033004)	2.54894696
72	postsynaptic membrane organization (GO:0001941)	2.52548772
73	amine catabolic process (GO:0009310)	2.50051094
74	cellular biogenic amine catabolic process (GO:0042402)	2.50051094
75	presynaptic membrane organization (GO:0097090)	2.49827705
76	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.45369133
77	regulation of glucokinase activity (GO:0033131)	2.44377738
78	regulation of hexokinase activity (GO:1903299)	2.44377738
79	regulation of microtubule-based movement (GO:0060632)	2.44207007
80	reflex (GO:0060004)	2.43681708
81	spinal cord motor neuron differentiation (GO:0021522)	2.42551176
82	cilium organization (GO:0044782)	2.42334001
83	parturition (GO:0007567)	2.41686171
84	preassembly of GPI anchor in ER membrane (GO:0016254)	2.41300298
85	neural tube formation (GO:0001841)	2.40922403
86	cAMP catabolic process (GO:0006198)	2.40259265
87	rhodopsin mediated signaling pathway (GO:0016056)	2.38540578
88	retinal cone cell development (GO:0046549)	2.38343586
89	glycerophospholipid catabolic process (GO:0046475)	2.35894061
90	photoreceptor cell development (GO:0042461)	2.35633064
91	cilium assembly (GO:0042384)	2.35437768
92	electron transport chain (GO:0022900)	2.35155593
93	somite rostral/caudal axis specification (GO:0032525)	2.34666999
94	regulation of neurotransmitter uptake (GO:0051580)	2.32410391
95	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.32083621
96	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.32083621
97	fucosylation (GO:0036065)	2.31954400
98	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.31877597
99	action potential (GO:0001508)	2.30287139
100	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.30249183

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.76152902
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.71308708
3	VDR_22108803_ChIP-Seq_LS180_Human	3.23431812
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.75558358
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.63196604
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.57022087
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.39610358
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.20291640
9	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.14381381
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.06155087
11	FUS_26573619_Chip-Seq_HEK293_Human	2.05190178
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.04085426
13	EWS_26573619_Chip-Seq_HEK293_Human	2.02503412
14	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.02492144
15	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.02485315
16	TAF15_26573619_Chip-Seq_HEK293_Human	2.01290784
17	IGF1R_20145208_ChIP-Seq_DFB_Human	1.95363626
18	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.95035517
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.94017439
20	P300_19829295_ChIP-Seq_ESCs_Human	1.90529388
21	REST_21632747_ChIP-Seq_MESCs_Mouse	1.76918404
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.74136736
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.71300812
24	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.69598821
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.67316458
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.65099118
27	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.57905059
28	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.57357990
29	RNF2_27304074_Chip-Seq_NSC_Mouse	1.56698766
30	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.56365794
31	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.54930441
32	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.52264821
33	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.51662679
34	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.50253303
35	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.48278618
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.47179098
37	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.46586185
38	TP53_22573176_ChIP-Seq_HFKS_Human	1.46534386
39	AR_25329375_ChIP-Seq_VCAP_Human	1.44771848
40	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.44631440
41	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.42596081
42	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.42596081
43	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.42582958
44	BCAT_22108803_ChIP-Seq_LS180_Human	1.42084790
45	MYC_18940864_ChIP-ChIP_HL60_Human	1.41710009
46	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.41515797
47	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.41434316
48	SMAD4_21799915_ChIP-Seq_A2780_Human	1.39062340
49	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.37492680
50	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.36223165
51	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.35512069
52	STAT3_23295773_ChIP-Seq_U87_Human	1.35280567
53	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.34945941
54	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.32910007
55	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.31657665
56	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.29994104
57	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.29994104
58	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.28719789
59	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.27012377
60	CBP_20019798_ChIP-Seq_JUKART_Human	1.27012377
61	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.26073683
62	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.25980585
63	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.24235794
64	NANOG_19829295_ChIP-Seq_ESCs_Human	1.23644876
65	SOX2_19829295_ChIP-Seq_ESCs_Human	1.23644876
66	TCF4_23295773_ChIP-Seq_U87_Human	1.22392887
67	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.22213657
68	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.22132473
69	AR_21572438_ChIP-Seq_LNCaP_Human	1.21770096
70	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.20989042
71	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.20976989
72	TCF4_22108803_ChIP-Seq_LS180_Human	1.20358823
73	RUNX2_22187159_ChIP-Seq_PCA_Human	1.19985592
74	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.19980071
75	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.19386433
76	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.19221154
77	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.18782242
78	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.16845030
79	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.16662710
80	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.16660891
81	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.16341345
82	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.12731632
83	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.12487723
84	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.12451394
85	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.11199033
86	NCOR_22424771_ChIP-Seq_293T_Human	1.10471913
87	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.10238226
88	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.10021636
89	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.09059988
90	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.08039949
91	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.05454413
92	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.05299389
93	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.05160096
94	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.03188896
95	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01143546
96	AR_20517297_ChIP-Seq_VCAP_Human	1.00642970
97	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.00425696
98	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.98556071
99	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.98374915
100	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.98173579

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	2.70186933
2	MP0003195_calcinosis	2.66427919
3	MP0008877_abnormal_DNA_methylation	2.50985205
4	MP0003136_yellow_coat_color	2.48460190
5	MP0004885_abnormal_endolymph	2.38224024
6	MP0005551_abnormal_eye_electrophysiolog	2.34664303
7	MP0002102_abnormal_ear_morphology	2.30032205
8	MP0004142_abnormal_muscle_tone	2.10739001
9	MP0009745_abnormal_behavioral_response	2.08450966
10	MP0001968_abnormal_touch/_nociception	2.07608190
11	MP0002837_dystrophic_cardiac_calcinosis	2.06937626
12	MP0003787_abnormal_imprinting	2.04578014
13	MP0001485_abnormal_pinna_reflex	2.03423019
14	MP0000569_abnormal_digit_pigmentation	2.02552206
15	MP0003646_muscle_fatigue	1.98640938
16	MP0009046_muscle_twitch	1.96027320
17	MP0002272_abnormal_nervous_system	1.88766258
18	MP0002653_abnormal_ependyma_morphology	1.88140031
19	MP0002938_white_spotting	1.85856020
20	MP0001986_abnormal_taste_sensitivity	1.82601160
21	MP0006072_abnormal_retinal_apoptosis	1.77766007
22	MP0003880_abnormal_central_pattern	1.76198903
23	MP0000372_irregular_coat_pigmentation	1.74682209
24	MP0004133_heterotaxia	1.72604522
25	MP0008875_abnormal_xenobiotic_pharmacok	1.72328690
26	MP0004147_increased_porphyrin_level	1.72246037
27	MP0002736_abnormal_nociception_after	1.71695579
28	MP0008872_abnormal_physiological_respon	1.69726257
29	MP0002876_abnormal_thyroid_physiology	1.69547665
30	MP0005646_abnormal_pituitary_gland	1.67013946
31	MP0002735_abnormal_chemical_nociception	1.63817440
32	MP0002638_abnormal_pupillary_reflex	1.63367067
33	MP0001486_abnormal_startle_reflex	1.61545391
34	MP0004742_abnormal_vestibular_system	1.59044250
35	MP0000631_abnormal_neuroendocrine_gland	1.57622128
36	MP0002163_abnormal_gland_morphology	1.55734214
37	MP0006276_abnormal_autonomic_nervous	1.54444872
38	MP0005084_abnormal_gallbladder_morpholo	1.50935633
39	MP0002064_seizures	1.50032316
40	MP0005645_abnormal_hypothalamus_physiol	1.48525961
41	MP0002572_abnormal_emotion/affect_behav	1.47769843
42	MP0001529_abnormal_vocalization	1.46591066
43	MP0005253_abnormal_eye_physiology	1.44203508
44	MP0001501_abnormal_sleep_pattern	1.41934251
45	MP0003011_delayed_dark_adaptation	1.37040611
46	MP0005174_abnormal_tail_pigmentation	1.35202053
47	MP0004043_abnormal_pH_regulation	1.33762979
48	MP0002557_abnormal_social/conspecific_i	1.32779105
49	MP0001970_abnormal_pain_threshold	1.32431182
50	MP0000778_abnormal_nervous_system	1.32102638
51	MP0003283_abnormal_digestive_organ	1.30127418
52	MP0002063_abnormal_learning/memory/cond	1.30010644
53	MP0003878_abnormal_ear_physiology	1.29216320
54	MP0005377_hearing/vestibular/ear_phenot	1.29216320
55	MP0003635_abnormal_synaptic_transmissio	1.28888602
56	MP0002733_abnormal_thermal_nociception	1.28525313
57	MP0002734_abnormal_mechanical_nocicepti	1.27842117
58	MP0001905_abnormal_dopamine_level	1.24892699
59	MP0002277_abnormal_respiratory_mucosa	1.24744659
60	MP0005423_abnormal_somatic_nervous	1.24695049
61	MP0004145_abnormal_muscle_electrophysio	1.21545624
62	MP0002067_abnormal_sensory_capabilities	1.19526787
63	MP0001984_abnormal_olfaction	1.19485666
64	MP0000427_abnormal_hair_cycle	1.16531712
65	MP0003122_maternal_imprinting	1.15586375
66	MP0002160_abnormal_reproductive_system	1.15007680
67	MP0002928_abnormal_bile_duct	1.14769248
68	MP0000026_abnormal_inner_ear	1.13488130
69	MP0005379_endocrine/exocrine_gland_phen	1.13180928
70	MP0005389_reproductive_system_phenotype	1.11407180
71	MP0005195_abnormal_posterior_eye	1.10925073
72	MP0003121_genomic_imprinting	1.07648463
73	MP0002234_abnormal_pharynx_morphology	1.07064544
74	MP0001440_abnormal_grooming_behavior	1.06719414
75	MP0004924_abnormal_behavior	1.06092463
76	MP0005386_behavior/neurological_phenoty	1.06092463
77	MP0003890_abnormal_embryonic-extraembry	1.05602859
78	MP0001919_abnormal_reproductive_system	1.01923223
79	MP0001963_abnormal_hearing_physiology	1.00901281
80	MP0002184_abnormal_innervation	1.00459052
81	MP0002752_abnormal_somatic_nervous	1.00088415
82	MP0000049_abnormal_middle_ear	0.99202481
83	MP0003137_abnormal_impulse_conducting	0.97591728
84	MP0009379_abnormal_foot_pigmentation	0.96535515
85	MP0001293_anophthalmia	0.94492945
86	MP0001188_hyperpigmentation	0.91877752
87	MP0004215_abnormal_myocardial_fiber	0.91082202
88	MP0001324_abnormal_eye_pigmentation	0.90824605
89	MP0003119_abnormal_digestive_system	0.89569701
90	MP0002095_abnormal_skin_pigmentation	0.89266479
91	MP0001502_abnormal_circadian_rhythm	0.86813409
92	MP0000955_abnormal_spinal_cord	0.86551381
93	MP0002229_neurodegeneration	0.83604654
94	MP0000230_abnormal_systemic_arterial	0.82597145
95	MP0002751_abnormal_autonomic_nervous	0.82298850
96	MP0010386_abnormal_urinary_bladder	0.80242699
97	MP0002882_abnormal_neuron_morphology	0.79755497
98	MP0003937_abnormal_limbs/digits/tail_de	0.78432165
99	MP0003938_abnormal_ear_development	0.75878736
100	MP0002909_abnormal_adrenal_gland	0.73967718

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of midbrain morphology (HP:0002418)	4.21933614
2	Molar tooth sign on MRI (HP:0002419)	4.21933614
3	Pancreatic cysts (HP:0001737)	4.21721089
4	Pancreatic fibrosis (HP:0100732)	3.85411916
5	True hermaphroditism (HP:0010459)	3.77949893
6	Nephronophthisis (HP:0000090)	3.72772783
7	Congenital stationary night blindness (HP:0007642)	3.72485017
8	Type II lissencephaly (HP:0007260)	3.28423760
9	Abnormality of the renal medulla (HP:0100957)	3.10252357
10	Abnormality of the renal cortex (HP:0011035)	2.89620001
11	Attenuation of retinal blood vessels (HP:0007843)	2.86223310
12	Medial flaring of the eyebrow (HP:0010747)	2.83441565
13	Pendular nystagmus (HP:0012043)	2.75124108
14	Chronic hepatic failure (HP:0100626)	2.70270176
15	Congenital, generalized hypertrichosis (HP:0004540)	2.69649891
16	Acute necrotizing encephalopathy (HP:0006965)	2.63717129
17	Large for gestational age (HP:0001520)	2.62483962
18	Hyperventilation (HP:0002883)	2.58116741
19	Inability to walk (HP:0002540)	2.54012887
20	Tubular atrophy (HP:0000092)	2.53155599
21	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.52654470
22	Abnormality of alanine metabolism (HP:0010916)	2.52654470
23	Hyperalaninemia (HP:0003348)	2.52654470
24	Abolished electroretinogram (ERG) (HP:0000550)	2.50268395
25	Sclerocornea (HP:0000647)	2.48139615
26	Cystic liver disease (HP:0006706)	2.46175044
27	Keratoconus (HP:0000563)	2.41007360
28	Increased corneal curvature (HP:0100692)	2.41007360
29	Abnormal rod and cone electroretinograms (HP:0008323)	2.40773454
30	Concave nail (HP:0001598)	2.37894609
31	Mitochondrial inheritance (HP:0001427)	2.37441264
32	Gait imbalance (HP:0002141)	2.34976202
33	Progressive cerebellar ataxia (HP:0002073)	2.34819499
34	Acute encephalopathy (HP:0006846)	2.34691448
35	Furrowed tongue (HP:0000221)	2.34099122
36	Progressive macrocephaly (HP:0004481)	2.29683550
37	Optic disc pallor (HP:0000543)	2.27350933
38	Increased CSF lactate (HP:0002490)	2.25418483
39	Birth length less than 3rd percentile (HP:0003561)	2.24386526
40	Polydipsia (HP:0001959)	2.24372897
41	Abnormal drinking behavior (HP:0030082)	2.24372897
42	Aplasia/Hypoplasia of the patella (HP:0006498)	2.22379890
43	Patellar aplasia (HP:0006443)	2.22001105
44	Congenital primary aphakia (HP:0007707)	2.20003402
45	Absent/shortened dynein arms (HP:0200106)	2.19888240
46	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.19888240
47	Abnormal mitochondria in muscle tissue (HP:0008316)	2.17552076
48	Lissencephaly (HP:0001339)	2.16358171
49	Hypothermia (HP:0002045)	2.15905213
50	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.15498116
51	Abnormal respiratory motile cilium morphology (HP:0005938)	2.15416232
52	Abnormal respiratory epithelium morphology (HP:0012253)	2.15416232
53	Methylmalonic acidemia (HP:0002912)	2.14770391
54	Anencephaly (HP:0002323)	2.12695011
55	Optic nerve hypoplasia (HP:0000609)	2.11726572
56	Broad-based gait (HP:0002136)	2.07601253
57	3-Methylglutaconic aciduria (HP:0003535)	2.06821275
58	Limb dystonia (HP:0002451)	2.05779949
59	Progressive inability to walk (HP:0002505)	2.05753229
60	Rib fusion (HP:0000902)	2.05266214
61	Cerebellar dysplasia (HP:0007033)	2.03982006
62	Abnormality of the pons (HP:0007361)	2.03581611
63	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.02453590
64	Abnormality of the labia minora (HP:0012880)	2.01672741
65	Severe muscular hypotonia (HP:0006829)	2.01629128
66	Renal cortical cysts (HP:0000803)	2.01480104
67	Nephrogenic diabetes insipidus (HP:0009806)	2.00552090
68	Decreased central vision (HP:0007663)	1.99834066
69	Abnormal number of erythroid precursors (HP:0012131)	1.98174594
70	Male pseudohermaphroditism (HP:0000037)	1.97630695
71	Retinal dysplasia (HP:0007973)	1.96851663
72	Polyuria (HP:0000103)	1.93965386
73	Septo-optic dysplasia (HP:0100842)	1.91878948
74	Congenital hepatic fibrosis (HP:0002612)	1.91744774
75	Hemiparesis (HP:0001269)	1.91564772
76	Hypoplasia of the pons (HP:0012110)	1.91033410
77	Lipid accumulation in hepatocytes (HP:0006561)	1.90247760
78	Increased hepatocellular lipid droplets (HP:0006565)	1.89567236
79	Chorioretinal atrophy (HP:0000533)	1.89381308
80	Genital tract atresia (HP:0001827)	1.88877211
81	Tachypnea (HP:0002789)	1.88232571
82	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.87691905
83	Agitation (HP:0000713)	1.87470569
84	Vaginal atresia (HP:0000148)	1.85711828
85	Protruding tongue (HP:0010808)	1.83426372
86	Gaze-evoked nystagmus (HP:0000640)	1.79937631
87	Congenital sensorineural hearing impairment (HP:0008527)	1.78818093
88	Postaxial foot polydactyly (HP:0001830)	1.78801156
89	Hepatocellular necrosis (HP:0001404)	1.78104995
90	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.78101511
91	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.78039631
92	Abnormal ciliary motility (HP:0012262)	1.77155915
93	Decreased circulating renin level (HP:0003351)	1.76966520
94	Febrile seizures (HP:0002373)	1.76181974
95	Bony spicule pigmentary retinopathy (HP:0007737)	1.75898028
96	Focal motor seizures (HP:0011153)	1.73352946
97	Pachygyria (HP:0001302)	1.72897141
98	Methylmalonic aciduria (HP:0012120)	1.71287307
99	Postaxial hand polydactyly (HP:0001162)	1.68934723
100	Hepatic necrosis (HP:0002605)	1.68729150

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.05685967
2	ADRBK2	3.53466855
3	BMPR1B	2.93163386
4	CASK	2.85800859
5	WNK3	2.83714865
6	ZAK	2.71567596
7	MAP4K2	2.47878395
8	PINK1	2.37612720
9	WNK4	2.35609125
10	ACVR1B	2.30049823
11	INSRR	2.29060326
12	PNCK	2.28832418
13	TLK1	2.28124186
14	GRK1	2.24095851
15	TAOK3	2.06341853
16	NUAK1	1.99023425
17	MAPK13	1.86618933
18	MAP3K4	1.77501919
19	MARK1	1.65090701
20	DAPK2	1.61692183
21	CAMKK2	1.54869872
22	TNIK	1.50290164
23	DYRK2	1.48958295
24	STK39	1.42753057
25	OXSR1	1.41741694
26	BCKDK	1.39356171
27	TXK	1.37148789
28	PAK3	1.32627654
29	MAPK15	1.25682016
30	MAP2K7	1.24879509
31	ADRBK1	1.23173799
32	MKNK2	1.16606303
33	PRKCG	1.14550441
34	NTRK2	1.12563459
35	NTRK3	1.09134501
36	TGFBR1	1.08336530
37	SIK2	1.07571528
38	FGFR2	0.96064582
39	PHKG1	0.94456871
40	PHKG2	0.94456871
41	VRK1	0.94404857
42	MUSK	0.93165950
43	CSNK1G2	0.88748989
44	PRKCE	0.83579959
45	TRIM28	0.81907444
46	PIK3CA	0.81794110
47	EPHA4	0.80917649
48	STK16	0.78954065
49	CSNK1G1	0.78104569
50	WEE1	0.72892425
51	TIE1	0.72109320
52	TAF1	0.71063137
53	CAMK1G	0.70516908
54	CSNK1G3	0.68236113
55	CAMK1D	0.66283180
56	RPS6KA5	0.64713444
57	MAP2K6	0.64682615
58	CAMK2A	0.64527416
59	NEK2	0.61865712
60	IRAK1	0.61562469
61	CAMK1	0.58830500
62	MKNK1	0.58158587
63	CAMKK1	0.58094676
64	PLK2	0.56842486
65	PRKCQ	0.56791152
66	EPHA3	0.56784833
67	VRK2	0.56415374
68	PLK3	0.53201775
69	PRKACA	0.52899386
70	STK11	0.52209383
71	MAP2K4	0.51927910
72	TSSK6	0.51888090
73	MAPKAPK5	0.51327284
74	PKN1	0.51170439
75	GRK7	0.48799661
76	CSNK1A1L	0.48576620
77	PRKCI	0.47422598
78	IKBKB	0.46910512
79	BCR	0.45084599
80	PRKCZ	0.44166193
81	PLK4	0.44130147
82	CSNK1A1	0.43907973
83	PTK2B	0.42852100
84	PASK	0.41401510
85	NME1	0.41114978
86	DYRK3	0.39961823
87	RPS6KA6	0.38430308
88	MAPKAPK3	0.36592654
89	DYRK1A	0.35659870
90	MINK1	0.35168182
91	PRKCA	0.34853075
92	CHUK	0.34472550
93	EPHB2	0.33514398
94	PRKG1	0.32782662
95	OBSCN	0.30743045
96	PLK1	0.29286120
97	SGK2	0.28338632
98	CDK3	0.27850704
99	GRK5	0.27638025
100	NLK	0.27542515

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.91998280
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.88253024
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.56677871
4	Nicotine addiction_Homo sapiens_hsa05033	2.49462731
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.44427287
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.42083123
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.33740654
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.30669930
9	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.27051758
10	Butanoate metabolism_Homo sapiens_hsa00650	2.23568558
11	Parkinsons disease_Homo sapiens_hsa05012	2.22400092
12	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.21116154
13	Selenocompound metabolism_Homo sapiens_hsa00450	2.16202636
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.97504291
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.96055964
16	Protein export_Homo sapiens_hsa03060	1.94549415
17	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.93472462
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.88839874
19	Ether lipid metabolism_Homo sapiens_hsa00565	1.74439418
20	Cardiac muscle contraction_Homo sapiens_hsa04260	1.69958265
21	Caffeine metabolism_Homo sapiens_hsa00232	1.56013136
22	RNA polymerase_Homo sapiens_hsa03020	1.53498695
23	Huntingtons disease_Homo sapiens_hsa05016	1.52977973
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.52942128
25	Alzheimers disease_Homo sapiens_hsa05010	1.52878708
26	Basal transcription factors_Homo sapiens_hsa03022	1.50267728
27	Ribosome_Homo sapiens_hsa03010	1.45800360
28	Morphine addiction_Homo sapiens_hsa05032	1.45122876
29	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.44883144
30	Taste transduction_Homo sapiens_hsa04742	1.40494920
31	Homologous recombination_Homo sapiens_hsa03440	1.33698851
32	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.30781094
33	Insulin secretion_Homo sapiens_hsa04911	1.24594935
34	Olfactory transduction_Homo sapiens_hsa04740	1.21270791
35	RNA degradation_Homo sapiens_hsa03018	1.15417824
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.14507641
37	Glutamatergic synapse_Homo sapiens_hsa04724	1.13589061
38	Fanconi anemia pathway_Homo sapiens_hsa03460	1.12955330
39	GABAergic synapse_Homo sapiens_hsa04727	1.12466669
40	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.11869472
41	Sulfur relay system_Homo sapiens_hsa04122	1.09449401
42	Chemical carcinogenesis_Homo sapiens_hsa05204	1.07265642
43	Serotonergic synapse_Homo sapiens_hsa04726	1.06321859
44	Propanoate metabolism_Homo sapiens_hsa00640	1.06159495
45	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.05534696
46	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.05232678
47	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.04822502
48	Circadian entrainment_Homo sapiens_hsa04713	1.04532688
49	Peroxisome_Homo sapiens_hsa04146	1.03089442
50	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.96433974
51	ABC transporters_Homo sapiens_hsa02010	0.94717278
52	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.93598631
53	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.92508562
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.92066289
55	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.86688000
56	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.85924858
57	Collecting duct acid secretion_Homo sapiens_hsa04966	0.84830538
58	One carbon pool by folate_Homo sapiens_hsa00670	0.83920562
59	Cocaine addiction_Homo sapiens_hsa05030	0.79604960
60	Fat digestion and absorption_Homo sapiens_hsa04975	0.77595789
61	Retinol metabolism_Homo sapiens_hsa00830	0.76888009
62	Regulation of autophagy_Homo sapiens_hsa04140	0.75198150
63	Sulfur metabolism_Homo sapiens_hsa00920	0.72859522
64	Steroid biosynthesis_Homo sapiens_hsa00100	0.71407758
65	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.69687514
66	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.68995402
67	Dopaminergic synapse_Homo sapiens_hsa04728	0.68260179
68	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.67369312
69	Salivary secretion_Homo sapiens_hsa04970	0.66535071
70	Calcium signaling pathway_Homo sapiens_hsa04020	0.66500380
71	Purine metabolism_Homo sapiens_hsa00230	0.65691174
72	Mineral absorption_Homo sapiens_hsa04978	0.64639491
73	Glycerolipid metabolism_Homo sapiens_hsa00561	0.62357995
74	Metabolic pathways_Homo sapiens_hsa01100	0.59682303
75	Amphetamine addiction_Homo sapiens_hsa05031	0.55506840
76	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.55082172
77	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.54681501
78	Asthma_Homo sapiens_hsa05310	0.53565218
79	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.53208744
80	beta-Alanine metabolism_Homo sapiens_hsa00410	0.51768437
81	Basal cell carcinoma_Homo sapiens_hsa05217	0.51200332
82	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.49866188
83	Long-term depression_Homo sapiens_hsa04730	0.44740649
84	Cholinergic synapse_Homo sapiens_hsa04725	0.44336025
85	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.44167449
86	Histidine metabolism_Homo sapiens_hsa00340	0.43345137
87	Circadian rhythm_Homo sapiens_hsa04710	0.43171626
88	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.43039749
89	Gastric acid secretion_Homo sapiens_hsa04971	0.41641610
90	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.41091637
91	Proteasome_Homo sapiens_hsa03050	0.40892039
92	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.39294155
93	cAMP signaling pathway_Homo sapiens_hsa04024	0.35782766
94	Pyrimidine metabolism_Homo sapiens_hsa00240	0.34888441
95	Primary immunodeficiency_Homo sapiens_hsa05340	0.34516929
96	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.34370380
97	Folate biosynthesis_Homo sapiens_hsa00790	0.34356317
98	Axon guidance_Homo sapiens_hsa04360	0.32964728
99	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.32808591
100	Type I diabetes mellitus_Homo sapiens_hsa04940	0.32604379

CCNB3P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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