CCNC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)4.95906199
2chaperone-mediated protein transport (GO:0072321)4.41239479
3chromatin remodeling at centromere (GO:0031055)4.37446316
4CENP-A containing nucleosome assembly (GO:0034080)4.31538482
5ribosome assembly (GO:0042255)4.27653959
6DNA replication checkpoint (GO:0000076)4.26167092
7cullin deneddylation (GO:0010388)4.17397382
8proteasome assembly (GO:0043248)4.03589267
9protein deneddylation (GO:0000338)3.96441849
10establishment of integrated proviral latency (GO:0075713)3.93665862
11histone exchange (GO:0043486)3.93501524
12regulation of mitotic spindle checkpoint (GO:1903504)3.89089234
13regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.89089234
14presynaptic membrane assembly (GO:0097105)3.88297880
15negative regulation of synaptic transmission, GABAergic (GO:0032229)3.86735657
16protein complex biogenesis (GO:0070271)3.72626575
17purine nucleobase biosynthetic process (GO:0009113)3.68266782
18negative regulation of DNA-dependent DNA replication (GO:2000104)3.68054633
19double-strand break repair via nonhomologous end joining (GO:0006303)3.67580659
20non-recombinational repair (GO:0000726)3.67580659
21regulation of helicase activity (GO:0051095)3.64253249
22transferrin transport (GO:0033572)3.63597366
23mitotic metaphase plate congression (GO:0007080)3.60678071
24establishment of protein localization to mitochondrial membrane (GO:0090151)3.59327137
25neuron cell-cell adhesion (GO:0007158)3.59253610
26IMP biosynthetic process (GO:0006188)3.58611326
27mitochondrial respiratory chain complex I assembly (GO:0032981)3.58347812
28NADH dehydrogenase complex assembly (GO:0010257)3.58347812
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.58347812
30somatic diversification of immune receptors via somatic mutation (GO:0002566)3.57925496
31somatic hypermutation of immunoglobulin genes (GO:0016446)3.57925496
32positive regulation of mitochondrial fission (GO:0090141)3.57497663
33water-soluble vitamin biosynthetic process (GO:0042364)3.53493294
34presynaptic membrane organization (GO:0097090)3.51447731
35mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.50072780
36negative regulation of dendrite morphogenesis (GO:0050774)3.48949820
377-methylguanosine RNA capping (GO:0009452)3.44209132
38RNA capping (GO:0036260)3.44209132
39protein localization to kinetochore (GO:0034501)3.43115286
40DNA strand elongation involved in DNA replication (GO:0006271)3.43089002
41DNA catabolic process, exonucleolytic (GO:0000738)3.42819167
427-methylguanosine mRNA capping (GO:0006370)3.42368625
43somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.41957484
44somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.41957484
45isotype switching (GO:0045190)3.41957484
46nucleobase biosynthetic process (GO:0046112)3.41004284
47trivalent inorganic cation transport (GO:0072512)3.38888378
48ferric iron transport (GO:0015682)3.38888378
49mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.38234755
50replication fork processing (GO:0031297)3.36395393
51DNA replication-dependent nucleosome assembly (GO:0006335)3.33945487
52DNA replication-dependent nucleosome organization (GO:0034723)3.33945487
53rRNA modification (GO:0000154)3.30266231
54DNA double-strand break processing (GO:0000729)3.29190736
55DNA replication-independent nucleosome organization (GO:0034724)3.28600974
56DNA replication-independent nucleosome assembly (GO:0006336)3.28600974
57metaphase plate congression (GO:0051310)3.28276189
58positive regulation of protein homodimerization activity (GO:0090073)3.27563448
59DNA strand elongation (GO:0022616)3.25032942
60phagosome maturation (GO:0090382)3.24209706
61telomere maintenance via semi-conservative replication (GO:0032201)3.23259267
62exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.22212682
63spindle checkpoint (GO:0031577)3.21867180
64serotonin receptor signaling pathway (GO:0007210)3.21222260
65respiratory chain complex IV assembly (GO:0008535)3.14717951
66regulation of DNA endoreduplication (GO:0032875)3.14695732
67nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.13351767
68nuclear pore organization (GO:0006999)3.13116343
69RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.12793955
70mitotic spindle checkpoint (GO:0071174)3.12680962
71dopamine transport (GO:0015872)3.11741985
72pseudouridine synthesis (GO:0001522)3.10100670
73DNA damage response, detection of DNA damage (GO:0042769)3.09003500
74IMP metabolic process (GO:0046040)3.08989125
75negative regulation of mitotic sister chromatid segregation (GO:0033048)3.08071297
76negative regulation of mitotic sister chromatid separation (GO:2000816)3.08071297
77negative regulation of sister chromatid segregation (GO:0033046)3.08071297
78negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.08071297
79negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.08071297
80rRNA methylation (GO:0031167)3.07396402
81protein localization to cilium (GO:0061512)3.06943928
82regulation of cellular amino acid metabolic process (GO:0006521)3.06844291
83energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.06764026
84ATP hydrolysis coupled proton transport (GO:0015991)3.06764026
85mitochondrial respiratory chain complex assembly (GO:0033108)3.05203872
86nuclear pore complex assembly (GO:0051292)3.03644927
87negative regulation of chromosome segregation (GO:0051985)3.03039291
88startle response (GO:0001964)3.02713995
89synapsis (GO:0007129)3.02255067
90GTP biosynthetic process (GO:0006183)3.01438614
91regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.00909783
92negative regulation of neurotransmitter transport (GO:0051589)2.99700202
93regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.99590527
94regulation of mitotic metaphase/anaphase transition (GO:0030071)2.99590527
95protein-cofactor linkage (GO:0018065)2.98311681
96telomere maintenance via recombination (GO:0000722)2.97961348
97ATP synthesis coupled proton transport (GO:0015986)2.97619747
98energy coupled proton transport, down electrochemical gradient (GO:0015985)2.97619747
99somatic recombination of immunoglobulin gene segments (GO:0016447)2.97600830
100negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.96574029
101regulation of centriole replication (GO:0046599)2.96557677
102mitotic recombination (GO:0006312)2.96537556
103mitochondrial RNA metabolic process (GO:0000959)2.94456856
104regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.92554420
105mitotic sister chromatid segregation (GO:0000070)2.92321209
106regulation of nuclear cell cycle DNA replication (GO:0033262)2.91672673
107synaptic vesicle exocytosis (GO:0016079)2.90875857
108response to X-ray (GO:0010165)2.90648680
109DNA ligation (GO:0006266)2.89818907
110positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.89544055
111establishment of viral latency (GO:0019043)2.89429132
112regulation of mitotic sister chromatid separation (GO:0010965)2.88424851
113regulation of mitotic sister chromatid segregation (GO:0033047)2.88424851
114regulation of sister chromatid segregation (GO:0033045)2.88424851
115guanosine-containing compound biosynthetic process (GO:1901070)2.86595382
116L-serine metabolic process (GO:0006563)2.85472508
117regulation of chromosome segregation (GO:0051983)2.83907668
118spindle assembly checkpoint (GO:0071173)2.83364138
119mitotic spindle assembly checkpoint (GO:0007094)2.82501332
120histone mRNA metabolic process (GO:0008334)2.81755902
121peptidyl-histidine modification (GO:0018202)2.80281736
122tRNA aminoacylation (GO:0043039)2.80253607
123amino acid activation (GO:0043038)2.80253607
124kinetochore organization (GO:0051383)2.78632399
125regulation of glutamate secretion (GO:0014048)2.78585539
126protein K6-linked ubiquitination (GO:0085020)2.78510887
127negative regulation of mast cell activation (GO:0033004)2.76951537
128ribonucleoprotein complex disassembly (GO:0032988)2.76295016
129DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.76034285
130response to redox state (GO:0051775)2.73946150
131organelle disassembly (GO:1903008)2.73588121
132regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.70103216
133signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.69529679
134signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.69529679
135signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.69529679
136signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.67925897
137intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.67925897
138antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.67680349
139gamma-aminobutyric acid signaling pathway (GO:0007214)2.67095376
140transcription elongation from RNA polymerase I promoter (GO:0006362)2.66959587
141long-chain fatty acid biosynthetic process (GO:0042759)2.66897306
142neuron-neuron synaptic transmission (GO:0007270)2.65704927
143respiratory electron transport chain (GO:0022904)2.65613695
144synaptic transmission, dopaminergic (GO:0001963)2.64453797
145ER overload response (GO:0006983)2.63592999
146intraciliary transport (GO:0042073)2.62384660
147regulation of mitochondrial translation (GO:0070129)2.61947433
148N-acetylglucosamine metabolic process (GO:0006044)2.61269757
149negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.60725235
150negative regulation of ligase activity (GO:0051352)2.60725235
151deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.59149905
152transcription elongation from RNA polymerase III promoter (GO:0006385)2.58867106
153termination of RNA polymerase III transcription (GO:0006386)2.58867106
154electron transport chain (GO:0022900)2.58530328
155inositol phosphate catabolic process (GO:0071545)2.57693959
156regulation of mitochondrial fission (GO:0090140)2.56955509
157antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.56098351
158anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.55268125
159cytochrome complex assembly (GO:0017004)2.54442688
160neutrophil activation involved in immune response (GO:0002283)2.54391371
161signal transduction involved in cell cycle checkpoint (GO:0072395)2.53824455
162maturation of 5.8S rRNA (GO:0000460)2.53232974
163signal transduction involved in DNA integrity checkpoint (GO:0072401)2.53037266
164signal transduction involved in DNA damage checkpoint (GO:0072422)2.53037266
165protein localization to synapse (GO:0035418)2.52363225
166signal peptide processing (GO:0006465)2.51450455
167regulation of cellular amine metabolic process (GO:0033238)2.50961137
168vocalization behavior (GO:0071625)2.49365435
169neurotransmitter uptake (GO:0001504)2.49303142
170positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.48316347
171establishment of protein localization to mitochondrion (GO:0072655)2.45126494
172detection of mechanical stimulus involved in sensory perception (GO:0050974)2.44918165
173regulation of amino acid transport (GO:0051955)2.44577967
174protein targeting to mitochondrion (GO:0006626)2.43541603
175negative regulation of neurotransmitter secretion (GO:0046929)2.43394882
176natural killer cell activation involved in immune response (GO:0002323)2.43210719
177negative regulation of membrane potential (GO:0045837)2.43122275
178negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.41459206
179nucleoside diphosphate phosphorylation (GO:0006165)2.41229387
180positive regulation of synapse assembly (GO:0051965)2.40856077

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.79850560
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.67422622
3GBX2_23144817_ChIP-Seq_PC3_Human3.49673233
4TAF15_26573619_Chip-Seq_HEK293_Human3.02462575
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.98502153
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.97085556
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.93076546
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.88859295
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.88738943
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.87758535
11VDR_22108803_ChIP-Seq_LS180_Human2.82384155
12* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.75498318
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.47933979
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.46778992
15FUS_26573619_Chip-Seq_HEK293_Human2.45829140
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.41793937
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.34711439
18P300_19829295_ChIP-Seq_ESCs_Human2.27378090
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.24181022
20KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.23207479
21AR_21909140_ChIP-Seq_LNCAP_Human2.15303992
22PCGF2_27294783_Chip-Seq_ESCs_Mouse2.14851873
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.10365237
24ELK1_19687146_ChIP-ChIP_HELA_Human2.05728149
25* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.04026264
26EWS_26573619_Chip-Seq_HEK293_Human1.99901135
27* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99760177
28FOXP3_21729870_ChIP-Seq_TREG_Human1.92656948
29ZNF274_21170338_ChIP-Seq_K562_Hela1.90406264
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.89270545
31* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.83652606
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.78599345
33ER_23166858_ChIP-Seq_MCF-7_Human1.77939849
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.75113047
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75006896
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70957095
37EZH2_22144423_ChIP-Seq_EOC_Human1.70197621
38* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.69660651
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.69394107
40SMAD4_21799915_ChIP-Seq_A2780_Human1.67772518
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.67655496
42* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.65870813
43MYC_18940864_ChIP-ChIP_HL60_Human1.64318563
44MYC_18358816_ChIP-ChIP_MESCs_Mouse1.63561629
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63397274
46* DCP1A_22483619_ChIP-Seq_HELA_Human1.61850358
47NANOG_18555785_Chip-Seq_ESCs_Mouse1.59333277
48* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.58059920
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57962491
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56838682
51HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.55639230
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.53595681
53EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.51508711
54IGF1R_20145208_ChIP-Seq_DFB_Human1.50672553
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.50002997
56* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.48573489
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48265548
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47903454
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.47887373
60E2F1_18555785_Chip-Seq_ESCs_Mouse1.45886664
61JUN_21703547_ChIP-Seq_K562_Human1.45389930
62* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45335953
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45172677
64NANOG_16153702_ChIP-ChIP_HESCs_Human1.43789839
65P53_22387025_ChIP-Seq_ESCs_Mouse1.43750923
66CREB1_15753290_ChIP-ChIP_HEK293T_Human1.43613684
67SRF_21415370_ChIP-Seq_HL-1_Mouse1.43568640
68NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.42820504
69FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.42552334
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.42450897
71* TTF2_22483619_ChIP-Seq_HELA_Human1.42207177
72STAT3_18555785_Chip-Seq_ESCs_Mouse1.41579315
73SUZ12_18555785_Chip-Seq_ESCs_Mouse1.40592610
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.38910640
75CMYC_18555785_Chip-Seq_ESCs_Mouse1.38451505
76MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38011303
77EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.36825578
78THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35603794
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33857295
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33786435
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32178598
82SOX2_18555785_Chip-Seq_ESCs_Mouse1.30964700
83* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30941445
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.30779644
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.30775851
86RNF2_27304074_Chip-Seq_NSC_Mouse1.30618399
87* GABP_19822575_ChIP-Seq_HepG2_Human1.30539546
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29811906
89EZH2_27294783_Chip-Seq_NPCs_Mouse1.29257684
90P300_18555785_Chip-Seq_ESCs_Mouse1.28530604
91CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.27964098
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.27824510
93FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.27494140
94* VDR_23849224_ChIP-Seq_CD4+_Human1.26865858
95NMYC_18555785_Chip-Seq_ESCs_Mouse1.26670456
96HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25753317
97ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.25421106
98PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25040446
99EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.24600691
100POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24490313
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23238970
102RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.23212124
103RUNX1_27457419_Chip-Seq_LIVER_Mouse1.22744615
104NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.22651478
105CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22584014
106PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22268575
107ELF1_17652178_ChIP-ChIP_JURKAT_Human1.21302903
108* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.20704993
109ETS1_20019798_ChIP-Seq_JURKAT_Human1.19818268
110* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19621994
111* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18440236
112AR_21572438_ChIP-Seq_LNCaP_Human1.17066024
113PRDM14_20953172_ChIP-Seq_ESCs_Human1.13937726
114CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12756981
115YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11912103
116STAT3_23295773_ChIP-Seq_U87_Human1.11102377
117SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.10794351
118AR_25329375_ChIP-Seq_VCAP_Human1.10743997
119POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10201165
120IRF1_19129219_ChIP-ChIP_H3396_Human1.10193254
121OCT4_18555785_Chip-Seq_ESCs_Mouse1.09348464
122SOX2_16153702_ChIP-ChIP_HESCs_Human1.09273492
123RUNX2_22187159_ChIP-Seq_PCA_Human1.08256129
124* REST_21632747_ChIP-Seq_MESCs_Mouse1.08103570
125BP1_19119308_ChIP-ChIP_Hs578T_Human1.07846830
126ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07412251
127MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06852175
128PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06832083
129SMAD1_18555785_Chip-Seq_ESCs_Mouse1.06674274
130TAL1_26923725_Chip-Seq_HPCs_Mouse1.04846627
131PU1_27457419_Chip-Seq_LIVER_Mouse1.04766301
132TP53_18474530_ChIP-ChIP_U2OS_Human1.04561861
133SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04248196
134KLF4_18555785_Chip-Seq_ESCs_Mouse1.04025184
135ZFX_18555785_Chip-Seq_ESCs_Mouse1.02698538
136GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02068579
137SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01407337
138* XRN2_22483619_ChIP-Seq_HELA_Human0.98378893
139ZFX_18555785_ChIP-Seq_MESCs_Mouse0.95823554
140KDM5A_27292631_Chip-Seq_BREAST_Human0.91139386
141SOX17_20123909_ChIP-Seq_XEN_Mouse0.91024209
142E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89934203
143NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88352284
144EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84303688
145NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.82069272
146SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.81009984
147EGR1_23403033_ChIP-Seq_LIVER_Mouse0.80786210
148SOX2_19829295_ChIP-Seq_ESCs_Human0.79268696
149NANOG_19829295_ChIP-Seq_ESCs_Human0.79268696
150NANOG_18555785_ChIP-Seq_MESCs_Mouse0.78470562
151KLF5_20875108_ChIP-Seq_MESCs_Mouse0.78268145

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.28333994
2MP0010094_abnormal_chromosome_stability4.21096806
3MP0003693_abnormal_embryo_hatching4.04619271
4MP0004957_abnormal_blastocyst_morpholog3.55640949
5MP0001984_abnormal_olfaction3.41380540
6MP0001188_hyperpigmentation3.28619820
7MP0002735_abnormal_chemical_nociception3.24010463
8MP0001529_abnormal_vocalization3.08796077
9MP0003111_abnormal_nucleus_morphology3.06838266
10MP0006276_abnormal_autonomic_nervous3.06251147
11MP0001968_abnormal_touch/_nociception3.06127846
12MP0002736_abnormal_nociception_after2.93085812
13MP0003941_abnormal_skin_development2.85212886
14MP0002876_abnormal_thyroid_physiology2.82374352
15MP0001986_abnormal_taste_sensitivity2.77930614
16MP0009046_muscle_twitch2.64137079
17MP0003077_abnormal_cell_cycle2.62929853
18MP0003890_abnormal_embryonic-extraembry2.55641855
19MP0001905_abnormal_dopamine_level2.50668409
20MP0002734_abnormal_mechanical_nocicepti2.45772512
21MP0008007_abnormal_cellular_replicative2.42923902
22MP0009745_abnormal_behavioral_response2.40494166
23MP0008932_abnormal_embryonic_tissue2.32853735
24MP0002064_seizures2.19788247
25MP0003635_abnormal_synaptic_transmissio2.16768183
26MP0002638_abnormal_pupillary_reflex2.13788003
27MP0002063_abnormal_learning/memory/cond2.10620082
28MP0004270_analgesia2.10194773
29MP0002572_abnormal_emotion/affect_behav2.09686979
30MP0005646_abnormal_pituitary_gland2.09677593
31MP0002272_abnormal_nervous_system2.07704291
32MP0001501_abnormal_sleep_pattern2.06145062
33MP0003806_abnormal_nucleotide_metabolis2.04348788
34MP0008260_abnormal_autophagy2.03256856
35MP0010386_abnormal_urinary_bladder2.00548870
36MP0005171_absent_coat_pigmentation1.87849379
37MP0001440_abnormal_grooming_behavior1.79640412
38MP0001970_abnormal_pain_threshold1.78540811
39MP0004859_abnormal_synaptic_plasticity1.78151324
40MP0002733_abnormal_thermal_nociception1.77831008
41MP0004142_abnormal_muscle_tone1.76134125
42MP0002067_abnormal_sensory_capabilities1.74806239
43MP0010352_gastrointestinal_tract_polyps1.70371269
44MP0003567_abnormal_fetal_cardiomyocyte1.67971324
45MP0002184_abnormal_innervation1.66158133
46MP0009697_abnormal_copulation1.66093256
47MP0005645_abnormal_hypothalamus_physiol1.65884876
48MP0002822_catalepsy1.64977888
49MP0002277_abnormal_respiratory_mucosa1.64772530
50MP0003937_abnormal_limbs/digits/tail_de1.63697531
51MP0006292_abnormal_olfactory_placode1.59925097
52MP0008789_abnormal_olfactory_epithelium1.59570024
53MP0001293_anophthalmia1.58713429
54MP0001486_abnormal_startle_reflex1.57394483
55MP0002163_abnormal_gland_morphology1.57366332
56MP0002254_reproductive_system_inflammat1.54758472
57MP0004924_abnormal_behavior1.52958535
58MP0005386_behavior/neurological_phenoty1.52958535
59MP0006036_abnormal_mitochondrial_physio1.49460690
60MP0003718_maternal_effect1.46318588
61MP0005499_abnormal_olfactory_system1.46134988
62MP0005394_taste/olfaction_phenotype1.46134988
63MP0001730_embryonic_growth_arrest1.44662284
64MP0002938_white_spotting1.42281936
65MP0001697_abnormal_embryo_size1.36950073
66MP0003136_yellow_coat_color1.36098432
67MP0000778_abnormal_nervous_system1.35743782
68MP0000350_abnormal_cell_proliferation1.25767520
69MP0002160_abnormal_reproductive_system1.23998431
70MP0003119_abnormal_digestive_system1.22820354
71MP0004215_abnormal_myocardial_fiber1.21759515
72MP0002084_abnormal_developmental_patter1.21420307
73MP0010307_abnormal_tumor_latency1.18189596
74MP0001542_abnormal_bone_strength1.17815581
75MP0002139_abnormal_hepatobiliary_system1.17014671
76MP0002557_abnormal_social/conspecific_i1.16417297
77MP0003787_abnormal_imprinting1.16148156
78MP0004782_abnormal_surfactant_physiolog1.15893760
79MP0000372_irregular_coat_pigmentation1.14047857
80MP0005379_endocrine/exocrine_gland_phen1.11706892
81MP0002751_abnormal_autonomic_nervous1.11451124
82MP0005380_embryogenesis_phenotype1.10270450
83MP0001672_abnormal_embryogenesis/_devel1.10270450
84MP0000647_abnormal_sebaceous_gland1.09187341
85MP0005551_abnormal_eye_electrophysiolog1.08692842
86MP0009672_abnormal_birth_weight1.06219975
87MP0001177_atelectasis1.06081731
88MP0002085_abnormal_embryonic_tissue1.05563180
89MP0001929_abnormal_gametogenesis1.05370430
90MP0000358_abnormal_cell_content/1.04633547
91MP0004133_heterotaxia1.04077144
92MP0002090_abnormal_vision1.03303762
93MP0001963_abnormal_hearing_physiology1.03287488
94MP0005332_abnormal_amino_acid1.03184326
95MP0003122_maternal_imprinting1.02167437
96MP0010234_abnormal_vibrissa_follicle1.01976130
97MP0005389_reproductive_system_phenotype1.01205246
98MP0002210_abnormal_sex_determination1.00846349
99MP0008875_abnormal_xenobiotic_pharmacok1.00116473
100MP0008877_abnormal_DNA_methylation0.99558563
101MP0005423_abnormal_somatic_nervous0.97410788
102MP0001145_abnormal_male_reproductive0.97058402
103MP0005395_other_phenotype0.96993520
104MP0001502_abnormal_circadian_rhythm0.96483203
105MP0000653_abnormal_sex_gland0.94294117
106MP0002233_abnormal_nose_morphology0.93573156
107MP0001286_abnormal_eye_development0.92832990
108MP0000516_abnormal_urinary_system0.92562501
109MP0005367_renal/urinary_system_phenotyp0.92562501
110MP0008057_abnormal_DNA_replication0.92297021
111MP0004811_abnormal_neuron_physiology0.91593865
112MP0002080_prenatal_lethality0.91074702
113MP0001666_abnormal_nutrient_absorption0.89500801
114MP0004197_abnormal_fetal_growth/weight/0.88969756
115MP0002066_abnormal_motor_capabilities/c0.88951812
116MP0001661_extended_life_span0.88943225
117MP0002088_abnormal_embryonic_growth/wei0.88865269
118MP0008872_abnormal_physiological_respon0.88606133
119MP0002882_abnormal_neuron_morphology0.88591674
120MP0005220_abnormal_exocrine_pancreas0.88105944
121MP0003984_embryonic_growth_retardation0.87922677
122MP0004742_abnormal_vestibular_system0.87072007
123MP0008058_abnormal_DNA_repair0.85798009
124MP0002148_abnormal_hypersensitivity_rea0.85635099
125MP0009703_decreased_birth_body0.84813265
126MP0002138_abnormal_hepatobiliary_system0.83612618
127MP0006082_CNS_inflammation0.83215056
128MP0001919_abnormal_reproductive_system0.82771860
129MP0003123_paternal_imprinting0.81814596
130MP0002697_abnormal_eye_size0.81732788
131MP0000631_abnormal_neuroendocrine_gland0.79621172
132MP0002009_preneoplasia0.79557971
133MP0000313_abnormal_cell_death0.78808804
134MP0010678_abnormal_skin_adnexa0.77538865
135MP0001119_abnormal_female_reproductive0.77500739
136MP0002752_abnormal_somatic_nervous0.77124837
137MP0005365_abnormal_bile_salt0.75979737
138MP0000015_abnormal_ear_pigmentation0.75685561
139MP0002102_abnormal_ear_morphology0.75468683
140MP0003724_increased_susceptibility_to0.74810085
141MP0008995_early_reproductive_senescence0.74537592
142MP0002837_dystrophic_cardiac_calcinosis0.74211572
143MP0005408_hypopigmentation0.74095737
144MP0003121_genomic_imprinting0.73740961
145MP0001485_abnormal_pinna_reflex0.72889056
146MP0002111_abnormal_tail_morphology0.72803210
147MP0003186_abnormal_redox_activity0.72234874
148MP0000026_abnormal_inner_ear0.71325975
149MP0000427_abnormal_hair_cycle0.70220701
150MP0001835_abnormal_antigen_presentation0.69939984
151MP0002229_neurodegeneration0.69708667
152MP0002086_abnormal_extraembryonic_tissu0.69689591
153MP0006054_spinal_hemorrhage0.69635872
154MP0009379_abnormal_foot_pigmentation0.68558971
155MP0006035_abnormal_mitochondrial_morpho0.68552102
156MP0005535_abnormal_body_temperature0.68490987
157MP0000955_abnormal_spinal_cord0.68372511
158MP0002234_abnormal_pharynx_morphology0.67929444
159MP0003786_premature_aging0.67408444
160MP0002332_abnormal_exercise_endurance0.66987661
161MP0006072_abnormal_retinal_apoptosis0.66328683
162MP0005187_abnormal_penis_morphology0.64254540
163MP0001764_abnormal_homeostasis0.63804345
164MP0005253_abnormal_eye_physiology0.63702679
165MP0005084_abnormal_gallbladder_morpholo0.62421438
166MP0003195_calcinosis0.61615072
167MP0000681_abnormal_thyroid_gland0.60511333
168MP0002069_abnormal_eating/drinking_beha0.59113697
169MP0003879_abnormal_hair_cell0.58822437

Predicted human phenotypes

RankGene SetZ-score
1Abnormal hair whorl (HP:0010721)4.53180293
2Acute necrotizing encephalopathy (HP:0006965)4.38160756
3Progressive macrocephaly (HP:0004481)3.98873520
4Focal motor seizures (HP:0011153)3.83277305
5Abnormal mitochondria in muscle tissue (HP:0008316)3.81289230
6Medial flaring of the eyebrow (HP:0010747)3.78865262
7Hypothermia (HP:0002045)3.76704782
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.66924099
9Mitochondrial inheritance (HP:0001427)3.65229972
10Gait imbalance (HP:0002141)3.58737694
11Colon cancer (HP:0003003)3.55010290
12Congenital primary aphakia (HP:0007707)3.50941931
13Chromsome breakage (HP:0040012)3.46259170
14Nephrogenic diabetes insipidus (HP:0009806)3.44228864
15Atonic seizures (HP:0010819)3.29878024
16Acute encephalopathy (HP:0006846)3.26095426
17Abnormality of chromosome stability (HP:0003220)3.25170325
18Increased CSF lactate (HP:0002490)3.23116590
19Febrile seizures (HP:0002373)3.20171346
20Abnormality of methionine metabolism (HP:0010901)3.17159497
21Neuroendocrine neoplasm (HP:0100634)3.16484114
22Meckel diverticulum (HP:0002245)3.15132137
23Increased serum pyruvate (HP:0003542)3.06862956
24Abnormality of glycolysis (HP:0004366)3.06862956
25Pheochromocytoma (HP:0002666)3.03863590
26Abnormality of the ileum (HP:0001549)3.00909536
27Methylmalonic acidemia (HP:0002912)2.95288823
28Aplasia/Hypoplasia of the uvula (HP:0010293)2.94555715
29Pancreatic fibrosis (HP:0100732)2.91449926
30Epileptic encephalopathy (HP:0200134)2.89273267
31Abnormality of the labia minora (HP:0012880)2.88367794
32Abnormality of aspartate family amino acid metabolism (HP:0010899)2.86540993
33Abnormal ciliary motility (HP:0012262)2.85560120
34Abnormality of the preputium (HP:0100587)2.84791057
35Genital tract atresia (HP:0001827)2.77370691
36Abnormal lung lobation (HP:0002101)2.75077655
37Increased hepatocellular lipid droplets (HP:0006565)2.74754249
38Hyperventilation (HP:0002883)2.72444398
39True hermaphroditism (HP:0010459)2.70318821
40Abnormality of serum amino acid levels (HP:0003112)2.69781357
41Vaginal atresia (HP:0000148)2.68596710
42Poor coordination (HP:0002370)2.66261067
43Protruding tongue (HP:0010808)2.64796195
44Ependymoma (HP:0002888)2.64308318
45Renal Fanconi syndrome (HP:0001994)2.63220524
46Birth length less than 3rd percentile (HP:0003561)2.58645800
47Absence seizures (HP:0002121)2.51155489
48Optic disc pallor (HP:0000543)2.49381092
49Pancreatic cysts (HP:0001737)2.48974074
50Nephroblastoma (Wilms tumor) (HP:0002667)2.46161214
51Dialeptic seizures (HP:0011146)2.45404601
52Embryonal renal neoplasm (HP:0011794)2.42484143
53Hepatocellular necrosis (HP:0001404)2.42401185
54Small intestinal stenosis (HP:0012848)2.41559181
55Duodenal stenosis (HP:0100867)2.41559181
56Limb dystonia (HP:0002451)2.38139026
57Parakeratosis (HP:0001036)2.37820372
58Neoplasm of the adrenal gland (HP:0100631)2.37213746
59Hypoglycemic coma (HP:0001325)2.37068194
60Pancreatic islet-cell hyperplasia (HP:0004510)2.36594698
61Abnormal respiratory motile cilium physiology (HP:0012261)2.32213690
62Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.31912496
63Methylmalonic aciduria (HP:0012120)2.31364999
64Hyperinsulinemic hypoglycemia (HP:0000825)2.26709458
65Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.23447548
66Abnormality of the duodenum (HP:0002246)2.23032876
67Glioma (HP:0009733)2.22289896
68Hypoglycemic seizures (HP:0002173)2.21964195
69Rhabdomyosarcoma (HP:0002859)2.20931522
70Hyperglycinemia (HP:0002154)2.20889589
71Sloping forehead (HP:0000340)2.18784748
723-Methylglutaconic aciduria (HP:0003535)2.18407160
73Abnormality of midbrain morphology (HP:0002418)2.17073938
74Molar tooth sign on MRI (HP:0002419)2.17073938
75Abnormal respiratory epithelium morphology (HP:0012253)2.16053244
76Abnormal respiratory motile cilium morphology (HP:0005938)2.16053244
77Stenosis of the external auditory canal (HP:0000402)2.15175532
78Alveolar cell carcinoma (HP:0006519)2.15092331
79Lipid accumulation in hepatocytes (HP:0006561)2.14876133
80Hypobetalipoproteinemia (HP:0003563)2.10669482
81Focal seizures (HP:0007359)2.09643359
82Exercise intolerance (HP:0003546)2.09583387
83Poor suck (HP:0002033)2.08765697
84Leukodystrophy (HP:0002415)2.06416143
85Increased serum lactate (HP:0002151)2.06289107
86Volvulus (HP:0002580)2.06033325
87Breast carcinoma (HP:0003002)2.03698187
88Progressive cerebellar ataxia (HP:0002073)2.02870688
89Ectopic kidney (HP:0000086)2.02804149
90Cerebral edema (HP:0002181)2.02539270
91Aplasia/Hypoplasia of the lens (HP:0008063)2.02536560
92Megaloblastic anemia (HP:0001889)2.02410819
93Chronic hepatic failure (HP:0100626)2.02222040
94Abnormality of glycine metabolism (HP:0010895)2.02151460
95Abnormality of serine family amino acid metabolism (HP:0010894)2.02151460
96Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.01873186
97Gonadotropin excess (HP:0000837)1.98960118
98Abnormality of vitamin B metabolism (HP:0004340)1.98686611
99Medulloblastoma (HP:0002885)1.98381657
100Autoamputation (HP:0001218)1.98025589
101Submucous cleft hard palate (HP:0000176)1.97955981
102Myokymia (HP:0002411)1.97428806
103Progressive inability to walk (HP:0002505)1.96933485
104Multiple enchondromatosis (HP:0005701)1.96851369
105Neoplasm of the colon (HP:0100273)1.95941942
106Homocystinuria (HP:0002156)1.95621780
107Abnormality of homocysteine metabolism (HP:0010919)1.95621780
108Neoplasm of the adrenal cortex (HP:0100641)1.95479031
109Carpal bone hypoplasia (HP:0001498)1.94921034
110Abnormality of the vitamin B12 metabolism (HP:0004341)1.94829614
111Type I transferrin isoform profile (HP:0003642)1.93000972
112Polyphagia (HP:0002591)1.92925414
113Hyperglycinuria (HP:0003108)1.91815611
114Retinal dysplasia (HP:0007973)1.91734002
115Specific learning disability (HP:0001328)1.91378736
116Astrocytoma (HP:0009592)1.90198527
117Abnormality of the astrocytes (HP:0100707)1.90198527
118Abnormality of sulfur amino acid metabolism (HP:0004339)1.89884257
119Abnormality of renal resorption (HP:0011038)1.89560690
120Adrenal hypoplasia (HP:0000835)1.89196609
121Lactic acidosis (HP:0003128)1.88658795
122Generalized tonic-clonic seizures (HP:0002069)1.88259399
123Pendular nystagmus (HP:0012043)1.88060464
124Biliary tract neoplasm (HP:0100574)1.87467298
125Ovarian neoplasm (HP:0100615)1.86430812
126Rhinitis (HP:0012384)1.86348185
127Clubbing of toes (HP:0100760)1.85540347
128Inability to walk (HP:0002540)1.85261790
129Triphalangeal thumb (HP:0001199)1.84072288
130Absent/shortened dynein arms (HP:0200106)1.82718900
131Dynein arm defect of respiratory motile cilia (HP:0012255)1.82718900
132Abnormality of the pons (HP:0007361)1.80629460
133Horseshoe kidney (HP:0000085)1.80563008
134Esotropia (HP:0000565)1.80540955
135Aganglionic megacolon (HP:0002251)1.78894313
136Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.78333388
137Degeneration of the lateral corticospinal tracts (HP:0002314)1.78333388
138Hepatic necrosis (HP:0002605)1.77257631
139Absent thumb (HP:0009777)1.76975264
140Respiratory failure (HP:0002878)1.76542513
141Abnormal autonomic nervous system physiology (HP:0012332)1.76046664
142X-linked dominant inheritance (HP:0001423)1.74745530
143Abolished electroretinogram (ERG) (HP:0000550)1.74593014
144Exertional dyspnea (HP:0002875)1.74033505
145Asthma (HP:0002099)1.73131745
146Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.72999830
147Lethargy (HP:0001254)1.72941032
148Conjunctival hamartoma (HP:0100780)1.72886590
149Myelodysplasia (HP:0002863)1.72761116
150Absent radius (HP:0003974)1.70877004
151Abnormality of the renal collecting system (HP:0004742)1.70041360
152Fair hair (HP:0002286)1.69935597
153Renal cortical cysts (HP:0000803)1.69840207
154Abnormality of endocrine pancreas physiology (HP:0012093)1.69144330
155Abnormality of the pancreatic islet cells (HP:0006476)1.69144330
156Delayed gross motor development (HP:0002194)1.68600878
157Meningioma (HP:0002858)1.68567748
158Duplicated collecting system (HP:0000081)1.68288234
159Congenital ichthyosiform erythroderma (HP:0007431)1.68034604
160Abnormality of alanine metabolism (HP:0010916)1.67971062
161Hyperalaninemia (HP:0003348)1.67971062
162Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.67971062
163Reticulocytopenia (HP:0001896)1.67935737
164Preaxial hand polydactyly (HP:0001177)1.67541818
165Delusions (HP:0000746)1.67231413
166Reduced antithrombin III activity (HP:0001976)1.65268670
167Aplasia/Hypoplasia of the tibia (HP:0005772)1.65094671
168Dysautonomia (HP:0002459)1.65039824
169Epileptiform EEG discharges (HP:0011182)1.64994972
170Diminished movement (HP:0002374)1.64546827
171Congenital, generalized hypertrichosis (HP:0004540)1.63503426
172Neoplasm of the tracheobronchial system (HP:0100552)1.62744494
173Broad-based gait (HP:0002136)1.62446534
174Agnosia (HP:0010524)1.61128941

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.80234493
2AKT33.26304091
3TRIM283.11491800
4MAP3K122.89000809
5TTK2.62803077
6CDC72.48964672
7NEK12.48202140
8PLK22.44802649
9MAP2K72.33661223
10BMPR22.31520253
11EIF2AK32.17823885
12ERBB32.11561158
13NTRK32.00330625
14TAF11.99637394
15VRK21.94191816
16ARAF1.89006383
17BCR1.81866453
18MST41.79613290
19ACVR1B1.76629067
20TNIK1.75983312
21MAP3K141.68869687
22BUB11.64512477
23PLK31.60896248
24SGK21.59787657
25TSSK61.59005477
26BRAF1.55538407
27BMPR1B1.55166047
28PRPF4B1.48473029
29CCNB11.47767372
30STK161.47608816
31ZAK1.45085014
32NME11.44497598
33YES11.38392288
34SRPK11.37552244
35PLK11.35731199
36VRK11.34705726
37SIK31.34381973
38PDK21.32253110
39EIF2AK11.29212994
40MAP4K21.27756038
41FRK1.26070930
42LIMK11.25630380
43SGK4941.23180455
44SGK2231.23180455
45PNCK1.22150497
46PBK1.21866650
47GRK51.19773153
48GRK71.18835835
49MAPK131.18180221
50MINK11.17435091
51PLK41.14699510
52RIPK41.12056915
53STK31.11183229
54MAP3K41.08196852
55PASK1.04993909
56STK391.04172529
57MARK11.03102380
58ADRBK21.01375526
59CSNK1G10.98415791
60EIF2AK20.98331733
61TXK0.97850157
62ATR0.93528721
63MKNK20.89413635
64CAMKK20.87953328
65CDK80.87933414
66NEK60.87058726
67ERBB40.86488539
68CAMK2B0.86249800
69CHEK20.84914375
70IRAK40.84794965
71DAPK10.83185348
72OXSR10.81911012
73STK240.80545008
74MKNK10.80416951
75LATS10.80042401
76PRKCE0.78693904
77CSNK1A1L0.78248238
78PRKCG0.77670837
79AURKB0.76438600
80DYRK1A0.74284113
81TGFBR10.73666712
82CAMK2A0.73405595
83NLK0.72682954
84NUAK10.71401656
85ATM0.71191765
86BRSK20.69505835
87PIM20.67573451
88DYRK20.65553050
89CDK30.65463238
90ALK0.64587869
91MAP2K40.63972817
92MUSK0.63413608
93EPHA40.62649887
94CHEK10.60920624
95WNK30.58342976
96FGFR10.57434071
97MAP3K130.56005470
98DAPK20.54223809
99ADRBK10.53213929
100MYLK0.52602657
101MAP3K90.51515853
102SGK30.50293102
103INSRR0.50002996
104RPS6KA40.49310716
105CAMK2D0.46966372
106AURKA0.46683068
107CAMK2G0.46285926
108IRAK10.46263414
109FLT30.46133834
110RPS6KA50.45348820
111NME20.44350690
112STK38L0.44259989
113CSNK2A10.43904127
114TLK10.43183598
115STK40.42524075
116CSNK1E0.41732002
117DYRK30.40787152
118CSNK1G30.40766376
119FGFR20.40425966
120BRSK10.39981450
121PRKCI0.39695434
122WNK40.38802810
123RPS6KB10.38511006
124KSR10.38000492
125GRK10.37975578
126CSNK2A20.37396174
127NEK20.37256693
128WEE10.37128986
129PTK2B0.36952924
130CDK50.36498334
131FGR0.36151115
132TIE10.35875238
133FER0.35709298
134NTRK20.35540300
135PINK10.34889855
136PRKACA0.34370437
137CSNK1G20.34260739
138PKN10.34017366
139STK100.33856343
140CDK70.33797512
141CDK180.33677571
142CDK140.33673950
143TESK10.33543747
144MELK0.32913404
145CSNK1A10.32570664
146CLK10.30193933
147PAK30.30172454
148CDK10.29155298
149BCKDK0.28949076
150MAPKAPK50.28376685
151PAK40.28150130
152PRKDC0.26976846
153MAP3K80.26077507

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.19284707
2Oxidative phosphorylation_Homo sapiens_hsa001903.67570308
3Collecting duct acid secretion_Homo sapiens_hsa049663.45138650
4DNA replication_Homo sapiens_hsa030302.96783603
5Nicotine addiction_Homo sapiens_hsa050332.87961819
6Parkinsons disease_Homo sapiens_hsa050122.77154469
7Synaptic vesicle cycle_Homo sapiens_hsa047212.74016496
8Protein export_Homo sapiens_hsa030602.61826513
9RNA polymerase_Homo sapiens_hsa030202.39671942
10Vibrio cholerae infection_Homo sapiens_hsa051102.22148748
11One carbon pool by folate_Homo sapiens_hsa006702.21663262
12Huntingtons disease_Homo sapiens_hsa050162.20817793
13Alzheimers disease_Homo sapiens_hsa050102.14901783
14Rheumatoid arthritis_Homo sapiens_hsa053232.14574596
15Propanoate metabolism_Homo sapiens_hsa006401.98339583
16SNARE interactions in vesicular transport_Homo sapiens_hsa041301.96275912
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.86660508
18Selenocompound metabolism_Homo sapiens_hsa004501.84857184
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.80367832
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.79291847
21Caffeine metabolism_Homo sapiens_hsa002321.74772735
22Serotonergic synapse_Homo sapiens_hsa047261.72480827
23Type I diabetes mellitus_Homo sapiens_hsa049401.70755249
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.70655623
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.66772145
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.63458678
27Taste transduction_Homo sapiens_hsa047421.62535320
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60553227
29Olfactory transduction_Homo sapiens_hsa047401.60540015
30Regulation of autophagy_Homo sapiens_hsa041401.59662867
31Pyruvate metabolism_Homo sapiens_hsa006201.59616941
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.59375685
33Basal transcription factors_Homo sapiens_hsa030221.57962051
34Phototransduction_Homo sapiens_hsa047441.57016917
35Autoimmune thyroid disease_Homo sapiens_hsa053201.50602848
36GABAergic synapse_Homo sapiens_hsa047271.49772040
37Phagosome_Homo sapiens_hsa041451.49101741
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.48315080
39Base excision repair_Homo sapiens_hsa034101.48150064
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.45699115
41Morphine addiction_Homo sapiens_hsa050321.41881922
42Ribosome_Homo sapiens_hsa030101.35338784
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.34964776
44Steroid biosynthesis_Homo sapiens_hsa001001.33057892
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.32175296
46Vitamin B6 metabolism_Homo sapiens_hsa007501.30452524
47Allograft rejection_Homo sapiens_hsa053301.30210760
48Graft-versus-host disease_Homo sapiens_hsa053321.29115633
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.29079677
50Dopaminergic synapse_Homo sapiens_hsa047281.25056375
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.24063219
52Amphetamine addiction_Homo sapiens_hsa050311.22200042
53Butanoate metabolism_Homo sapiens_hsa006501.11758286
54Pentose and glucuronate interconversions_Homo sapiens_hsa000401.11358283
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09857082
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08899406
57Circadian entrainment_Homo sapiens_hsa047131.07136471
58Long-term potentiation_Homo sapiens_hsa047201.06701807
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06622740
60Tryptophan metabolism_Homo sapiens_hsa003801.04537308
61Pyrimidine metabolism_Homo sapiens_hsa002401.03630170
62Maturity onset diabetes of the young_Homo sapiens_hsa049501.03370135
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.98658474
64Glutamatergic synapse_Homo sapiens_hsa047240.94969020
65Nucleotide excision repair_Homo sapiens_hsa034200.93520233
66Glutathione metabolism_Homo sapiens_hsa004800.91102979
67Purine metabolism_Homo sapiens_hsa002300.90093970
68Peroxisome_Homo sapiens_hsa041460.88518886
69Long-term depression_Homo sapiens_hsa047300.87650695
70Fatty acid elongation_Homo sapiens_hsa000620.86893263
71Retinol metabolism_Homo sapiens_hsa008300.84872721
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84794016
73Fatty acid degradation_Homo sapiens_hsa000710.84105148
74Folate biosynthesis_Homo sapiens_hsa007900.83776659
75Carbon metabolism_Homo sapiens_hsa012000.83222585
76Sphingolipid metabolism_Homo sapiens_hsa006000.81168064
77Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80441394
78p53 signaling pathway_Homo sapiens_hsa041150.80392726
79beta-Alanine metabolism_Homo sapiens_hsa004100.78194925
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.76479853
81Vitamin digestion and absorption_Homo sapiens_hsa049770.76185274
82Chemical carcinogenesis_Homo sapiens_hsa052040.75569201
83Homologous recombination_Homo sapiens_hsa034400.75238112
84RNA degradation_Homo sapiens_hsa030180.73835108
85Biosynthesis of amino acids_Homo sapiens_hsa012300.73727855
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73662051
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72456048
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70248699
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69628716
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69585991
91RNA transport_Homo sapiens_hsa030130.68389673
92Fatty acid metabolism_Homo sapiens_hsa012120.68181628
93Cholinergic synapse_Homo sapiens_hsa047250.65762476
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65078934
95Cocaine addiction_Homo sapiens_hsa050300.64051755
96African trypanosomiasis_Homo sapiens_hsa051430.63878735
97Sulfur metabolism_Homo sapiens_hsa009200.63565480
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63444563
99Epstein-Barr virus infection_Homo sapiens_hsa051690.63189830
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61338012
101Non-homologous end-joining_Homo sapiens_hsa034500.61164274
102Oocyte meiosis_Homo sapiens_hsa041140.61132674
103Ether lipid metabolism_Homo sapiens_hsa005650.59185360
104Alcoholism_Homo sapiens_hsa050340.58976791
105Steroid hormone biosynthesis_Homo sapiens_hsa001400.57803986
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57609328
107Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57244970
108Fat digestion and absorption_Homo sapiens_hsa049750.57107936
109Spliceosome_Homo sapiens_hsa030400.56800770
110Insulin secretion_Homo sapiens_hsa049110.56504593
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53936384
112N-Glycan biosynthesis_Homo sapiens_hsa005100.53271471
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52942061
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52244016
115Arachidonic acid metabolism_Homo sapiens_hsa005900.49107476
116Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48349111
117Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48120333
118Asthma_Homo sapiens_hsa053100.47978851
119Arginine and proline metabolism_Homo sapiens_hsa003300.47633092
120Fanconi anemia pathway_Homo sapiens_hsa034600.47427548
121Calcium signaling pathway_Homo sapiens_hsa040200.46776446
122Mismatch repair_Homo sapiens_hsa034300.44547506
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43460331
124Legionellosis_Homo sapiens_hsa051340.42779121
125Tyrosine metabolism_Homo sapiens_hsa003500.42168868
126Metabolic pathways_Homo sapiens_hsa011000.41823389
127Nitrogen metabolism_Homo sapiens_hsa009100.41742290
128Linoleic acid metabolism_Homo sapiens_hsa005910.40486730
129TGF-beta signaling pathway_Homo sapiens_hsa043500.40453935
130Intestinal immune network for IgA production_Homo sapiens_hsa046720.39588773
131Starch and sucrose metabolism_Homo sapiens_hsa005000.37373299
132RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35634925
133Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32270470
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31505065
135NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30888470
136Renin secretion_Homo sapiens_hsa049240.29892392
137Lysine degradation_Homo sapiens_hsa003100.29505687
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29310259
139Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29199818
140Salivary secretion_Homo sapiens_hsa049700.27941097
141Cardiac muscle contraction_Homo sapiens_hsa042600.26267649
142Prion diseases_Homo sapiens_hsa050200.25961955
143Circadian rhythm_Homo sapiens_hsa047100.24947947
144Tuberculosis_Homo sapiens_hsa051520.24742175
145Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24042554
146Systemic lupus erythematosus_Homo sapiens_hsa053220.24010786
147mRNA surveillance pathway_Homo sapiens_hsa030150.23397659
148Phosphatidylinositol signaling system_Homo sapiens_hsa040700.23336803
149alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22600944
150Hippo signaling pathway_Homo sapiens_hsa043900.22434435
151Cell cycle_Homo sapiens_hsa041100.22052031
152Melanoma_Homo sapiens_hsa052180.20679377
153Phenylalanine metabolism_Homo sapiens_hsa003600.20623282
154Sulfur relay system_Homo sapiens_hsa041220.19994974
155Gap junction_Homo sapiens_hsa045400.18018332
156Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.16726271
157Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15529904
158Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.14238627

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »